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https://www.readbyqxmd.com/read/29229216/immediate-complete-revascularization-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-disease-treated-by-primary-percutaneous-coronary-intervention-insights-from-the-orbi-registry
#1
Anna Pimor, Vincent Auffret, Romain Didier, Régis Delaunay, Emmanuelle Filippi, Jean-Philippe Hacot, Djamel Saouli, Gilles Rouault, Philippe Druelles, Emilie Bot, Isabelle Coudert, Bertrand Boulanger, Marielle Le Guellec, Dominique Boulmier, Guillaume Leurent, Marc Bedossa, Martine Gilard, Hervé Le Breton
BACKGROUND: Recent studies demonstrated the superiority of complete revascularization (CR) in patients treated by primary percutaneous coronary intervention (pPCI) in ST-elevation myocardial infarction (STEMI). AIM: To evaluate whether immediate CR improves in-hospital outcomes in patients with STEMI with multivessel disease. METHODS: Data from a prospective multicentre registry including 9365 patients with STEMI were analysed. Patients with multivessel disease and treated with pPCI (n=3412) were included and separated into two groups according to whether immediate CR was performed during the index procedure...
December 8, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28976026/scalp-hypothermia-as-a-preventative-measure-for-chemotherapy-induced-alopecia-a-review-of-controlled-clinical-trials
#2
REVIEW
V V Shah, T C Wikramanayake, G M DelCanto, C van den Hurk, S Wu, M E Lacouture, J J Jimenez
Chemotherapy-induced alopecia (CIA) is a temporary, yet psychologically devastating form of hair loss that affects 65% of patients receiving cancer chemotherapy. In the 1970s, scalp hypothermia was introduced as a preventative measure against the development of CIA. Numerous studies provide evidence for the effectiveness of scalp cooling to prevent CIA, although results varied because of differences in chemotherapy regimen, cooling technique, mode of administration and patient factors. However, many of the existing studies are uncontrolled or consist of small sample sizes, and data from randomized, randomized studies are limited...
October 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28864872/pathobiology-of-myomatosis-uteri-the-underlying-knowledge-to-support-our-clinical-practice
#3
REVIEW
Luz Angela Torres-de la Roche, Sven Becker, Cristina Cezar, Anja Hermann, Angelika Larbig, Lasse Leicher, Attilio Di Spiezio Sardo, Vasilis Tanos, Markus Wallwiener, Hugo Verhoeven, Rudy Leon De Wilde
INTRODUCTION: Uterine myomatosis, a benign condition, is the most common indication for hysterectomies worldwide, affecting the reproductive goals and quality of health of women. However, gynecologists have been provided with interesting insights on its pathobiology, which are the basis for uterine-preserving therapies. The aim of this paper is to discuss the latest evidence on these mechanisms and its importance in the clinical practice. METHOD: A comprehensive literature search was made in Pubmed, Medline, the Cochrane Library, Orbis plus and Google Scholar for articles related to the epidemiological, biological, and genetic bases...
October 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28503492/positive-effect-of-probiotics-on-constipation-in-children-a-systematic-review-and-meta-analysis-of-six-randomized-controlled-trials
#4
Ruixue Huang, Jianan Hu
Context: Constipation in children is a prevalent, burdensome, and psychologically important pediatric issue, the treatment of which remains a global challenge. The use of probiotics has been reported for management of the gastrointestinal microbiota. Objective: This study reviewed the existing literatures of 6 Randomized Control Trials (RCTs) to ascertain some baseline understanding and available information for the effects of probiotics on stool frequency and consistency in children with constipation. Data Sources: PubMed, Springer, Elsevier Science, Cochrane Library, Scopus, Ovid (Medline, EMBASE, PsycINFO), Orbis, and Web of Science from the earliest record in each database to 15 September, 2016...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28457284/corneal-surgery-in-the-flying-eye-hospital-characteristics-and-visual-outcome
#5
Javed Hussain Farooqui, Emile Sharifi, Ahmed Gomaa
OBJECTIVE: The Flying Eye Hospital (FEH) of ORBIS International is a capacity-building platform that trains ophthalmologists throughout the developing world on-board a fully functional eye hospital based in an airplane and in the local hospitals of developing countries. Corneal blindness (CB) is the second leading cause of blindness in most developing countries. Treatment of existing global CB requires effective eye banking and surgeons trained in corneal transplant. ORBIS International has programs that addressed both those needs...
April 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28430083/hydrocephalus-treatment-in-children-long-term-outcome-in-975-consecutive-patients
#6
Pierre-Aurelien Beuriat, Stephanie Puget, Giuseppe Cinalli, Thomas Blauwblomme, Kevin Beccaria, Michel Zerah, Christian Sainte-Rose
OBJECTIVE Hydrocephalus remains one of the more common pathologies managed in pediatric neurosurgical units. Endoscopic third ventriculostomy (ETV) has an advantage over ventriculoperitoneal shunting as it enables patients to remain device free. Multiple shunt devices with various valve designs exist, with no one valve proven to be superior to another. The aim of this study was to describe the management of hydrocephalus and its long-term outcome. METHODS The authors retrospectively reviewed the medical records of all patients who had been treated for hydrocephalus at the Hôpital Necker-Enfants Malades in the period from 1985 to 1995...
July 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28343347/bioanalysis-of-farnesyl-pyrophosphate-in-human-plasma-by-high-performance-liquid-chromatography-coupled-to-triple-quadrupole-tandem-mass-spectrometry-and-hybrid-quadrupole-orbitrap-high-resolution-mass-spectrometry
#7
Hiroshi Sugimoto, Mie Iguchi, Fumihiro Jinno
The isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) are pivotal intermediates for cholesterol homeostasis and cell signaling in the mevalonate pathway. We developed a sensitive and selective high-performance liquid chromatography tandem triple quadrupole mass spectrometry (LC-QQQ-MS) method for FPP in human plasma without the need for a derivatization process. We optimized the sample preparation procedure to extract FPP and (13)C5-FPP (as internal standard) from sample fluids using methanol...
March 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28271493/palatability-of-a-novel-oral-formulation-of-prednisone-in-healthy-young-adults
#8
RANDOMIZED CONTROLLED TRIAL
Shasha Bai, Nathan Dormer, Catherine Shoults, Amanda Meyer, Carol D Pierce, Kathleen A Neville, Gregory L Kearns
OBJECTIVES: Prednisone is a widely used anti-inflammatory for a variety of conditions. While oral liquid formulations of prednisone enable weight-based dosing, children frequently find them to be objectionable due to bitter taste. This limitation of prednisone can adversely impact patient acceptance and may result in non-compliance. Efforts to mask flavours often result in poorly controlled, heterogeneous particle distributions and can provide ineffective taste masking. The present work utilized a novel drug delivery technology developed by Orbis Biosciences, Inc...
April 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27970295/tct-130-complete-myocardial-revascularisation-is-not-associated-with-a-better-prognosis-in-cardiogenic-shock-complicating-st-elevation-myocardial-infarction-insight-from-the-multicenter-prospective-orbi-registry
#9
Guillaume Leurent, Ronan Garlantezec, Vincent Auffret, Emmanuelle Filippi, Martine Gilard, Djamel Saouli, Jean-Philippe Hacot, Gilles Rouault, Regis Delaunay, Dominique Boulmier, Marc Bedossa, Hervé Le Breton
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27916114/competitive-inhibition-assay-for-the-detection-of-progesterone-in-dairy-milk-using-a-fiber-optic-spr-biosensor
#10
D Daems, J Lu, F Delport, N Mariën, L Orbie, B Aernouts, I Adriaens, T Huybrechts, W Saeys, D Spasic, J Lammertyn
Analytical methods that are often used for the quantification of progesterone in bovine milk include immunoassays and chromatographic techniques. Depending on the selected method, the main disadvantages are the cost, time-to-result, labor intensity and usability as an automated at-line device. This paper reports for the first time on a robust and practical method to quantify small molecules, such as progesterone, in complex biological samples using an automated fiber optic surface plasmon resonance (FO-SPR) biosensor...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27908873/the-bmj-christmas-appeal-2016-7-orbis-the-sight-savers
#11
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27894229/-self-reported-experience-in-patients-treated-with-hepatitis-c-direct-acting-antivirals
#12
Irene Cañamares Orbis, Javier Saez de la Fuente, Ismael Escobar Rodriguez, Concepción Esteban Alba, Ana Such Díaz, Ismael Escobar Rodríguez
BACKGROUND AND OBJECTIVE: To learn about and analyze the self-reported treatment experience of HCV patients who started treatment with direct acting antivirals agents (DAA), at a real-time, proactive and integrated into the pharmaceutical care healthcare process, using a prospective questionnaire completed by patients as clinical tool. MATERIAL AND METHODS: Observational and cross-sectional study conducted between April (start of the National Strategic Plan) and December 2015 in the Outpatient Pharmacy Service...
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27894226/adaptation-of-oral-medication-in-people-institutionalized-in-nursing-homes-for-whom-medication-is-crushed-the-adecua-study
#13
MULTICENTER STUDY
Francisco Apolo Carvajal, María González Martínez, Elena Capilla Santamaría, Betsabé Cáliz Hernández, Icíar Cañamares Orbis, Nuria Martínez Casanova, Eugenia Martínez Sánchez, Ainhoa Aranguren Oyarzábal, María José Calvo Alcántara, Encarnación Cruz Martos
PURPOSE: To evaluate the effect of pharmacist interventions in the adaptation of pharmaceutical forms in elders institutionalized in nursing homes whose medicines are crushed, which may have a clinical relevance. METHODS: Quasi-experimental, multicenter, transversal and prospective study carried out in 10 nursing homes. Subjects for whom drugs were being crushed were identified. Their treatments were reviewed in order to identify drugs that should not be crushed...
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27818120/efficacy-and-safety-of-prehospital-administration-of-unfractionated-heparin-enoxaparin-or-bivalirudin-in-patients-undergoing-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction-insights-from-the-orbi-registry
#14
COMPARATIVE STUDY
Vincent Auffret, Guillaume Leurent, Dominique Boulmier, Marc Bedossa, Amer Zabalawi, Jean-Philippe Hacot, Isabelle Coudert, Emmanuelle Filippi, Philippe Castellant, Antoine Rialan, Gilles Rouault, Philippe Druelles, Bertrand Boulanger, Josiane Treuil, Bertrand Avez, Marielle Le Guellec, Martine Gilard, Hervé Le Breton
BACKGROUND: Despite numerous studies in recent years, the best anticoagulant option for primary percutaneous coronary intervention (PCI) remains a matter of debate. AIMS: To compare in-hospital outcomes after prehospital administration of low-dose unfractionated heparin (UFH)±glycoprotein IIb/IIIa inhibitors (GPIs), enoxaparin±GPIs, or bivalirudin in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI). METHODS: A total of 1720 patients (median age 62...
December 2016: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/27401364/a-protocol-for-a-randomised-controlled-trial-investigating-the-effect-of-increasing-omega-3-index-with-krill-oil-supplementation-on-learning-cognition-behaviour-and-visual-processing-in-typically-developing-adolescents
#15
I S M van der Wurff, C von Schacky, K Berge, P A Kirschner, R H M de Groot
INTRODUCTION: The influence of n-3 long-chain polyunsaturated fatty acids (LCPUFA) supplementation on brain functioning is debated. Some studies have found positive effects on cognition in children with learning difficulties, elderly people with cognitive impairment and depression scores in depressed individuals. Other studies have found null or negative effects. Observational studies in adolescents have found positive associations between fish consumption (containing n-3 LCPUFAs) and academic achievement...
July 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27395538/g-j-billberg-s-1833-on-the-ichthyology-and-description-of-some-new-fish-species-of-the-pipefish-genus-syngnathus
#16
Sven O Kullander
Gustaf Johan Billberg's review of ichthyology, published in Swedish in 1833 in the Linnéska samfundets handlingar, mentions 92 fish taxa at genus and species level, 41 of which represent new taxa, unnecessary replacement names, or unjustified emendations. Billberg presents his own classification of fishes, in which five new family names are introduced: Ballistidae, Diodontidae, Ooididae, Chironectidae, and Macrorhyncidae. Diodontidae has priority over Diodontidae Bonaparte, 1835. Macrorhyncidae was published earlier than Gempylidae Gill, 1862, but the latter has priority by prevailing usage...
January 14, 2016: Zootaxa
https://www.readbyqxmd.com/read/27381527/type-4-duane-syndrome
#17
Joshua A Schliesser, Derek T Sprunger, Eugene M Helveston
PURPOSE: To identify cases of synergistic divergence whose characteristics suggest that this entity is a form of Duane syndrome. METHODS: The records of all patients with a Duane syndrome diagnosis, including standardized eye position photographs, from the E-Consultation program of Cybersight, Orbis International were analyzed. RESULTS: A total of 350 Duane syndrome cases were identified. Of these, 19 (5%) had features consistent with synergistic divergence, or type 4 Duane syndrome...
August 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27371950/cross-cultural-adaptation-and-validation-of-the-medication-regimen-complexity-index-adapted-to-spanish
#18
Javier Saez de la Fuente, Ana Such Diaz, Irene Cañamares-Orbis, Estela Ramila, Elsa Izquierdo-Garcia, Concepcion Esteban, Ismael Escobar-Rodríguez
BACKGROUND: The most widely used validated instrument to assess the complexity of medication regimens is the Medication Regimen Complexity Index (MRCI). OBJECTIVE: This study aimed to translate, adapt, and validate a reliable version of the MRCI adapted to Spanish (MRCI-E). METHODS: The cross-cultural adaptation process consisted of an independent translation by 3 clinical pharmacists and a backtranslation by 2 native English speakers. A reliability analysis was conducted on 20 elderly randomly selected patients...
November 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27054621/does-staff-see-what-experts-see-accuracy-of-front-line-staff-in-scoring-juveniles-risk-factors
#19
Patrick J Kennealy, Jennifer L Skeem, Isaias R Hernandez
Although increasingly complex risk assessment tools are being marketed, little is known about "real world" practitioners' capacity to score them accurately. In this study, we assess the extent to which 78 staff members' scoring of juveniles on the California-Youth Assessment and Screening Instrument (CA-YASI; Orbis Partners, Inc., 2008) agree with experts' criterion scores for those cases. There are 3 key findings. First, at the total score level, practitioners manifest limited agreement (M ICC = .63) with the criterion: Only 59...
January 2017: Psychological Assessment
https://www.readbyqxmd.com/read/27005603/structure-solubility-and-stability-of-orbifloxacin-crystal-forms-hemihydrate-versus-anhydrate
#20
Olimpia Maria Martins Santos, Jennifer Tavares Jacon Freitas, Edith Cristina Laignier Cazedey, Magali Benjamim de Araújo, Antonio Carlos Doriguetto
Orbifloxacin (ORBI) is a widely used antimicrobial drug of the fluoroquinolone class. In the official pharmaceutical compendia the existence of polymorphism in this active pharmaceutical ingredient (API) is reported. No crystal structure has been reported for this API and as described in the literature, its solubility is very controversial. Considering that different solid forms of the same API may have different physicochemical properties, these different solubilities may have resulted from analyses inadvertently carried out on different polymorphs...
March 9, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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