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https://www.readbyqxmd.com/read/29145295/extrarenal-teratoma-with-nephroblastoma-in-the-retroperitoneum-case-report-and-literature-review
#1
Yanan Li, Chuanfen Lei, Bo Xiang, Fuyu Li, Chuan Wang, Qi Wang, Siyuan Chen, Yi Ji
RATIONALE: Teratoma with nephroblastoma is a rare disease. The most common site at which teratoma with nephroblastoma occurs is the kidney. The mechanisms underlying the development of teratoma with nephroblastoma have not been fully elucidated. PATIENT CONCERNS: In the current report, we describe the clinical characteristics of a 3-year-old girl with a complaint of a painless abdominal mass in the upper right side of the body. Ultrasonography and computed tomography revealed a cystic-solid mass with a clear boundary...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135843/abscessing-infection-by-streptococcus-mitis-mimicking-metastatic-lesions-in-a-5-year-old-girl-with-nephroblastoma-a-case-report
#2
Lara Imhof, Simone Schrading, Till Braunschweig, Gerhard Steinau, Jan Wilhelm Spillner, Alexander Puzik, Lisa Lassay, Udo Kontny
Streptococcus mitis is a common pathogen causing infections in oncological patients. However, cases of abscesses caused by Streptococcus mitis in oncological patients have not been reported so far. We report on 5-year-old child with nephroblastoma and pulmonary and hepatic metastases at diagnosis who went into complete remission undergoing chemotherapy and nephrectomy, and who developed new round lesions in liver and lungs under continuous chemotherapy suggestive of new metastases. Biopsy of the lesions revealed abscesses with detection of Streptococcus mitis...
November 13, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29131553/gata3-differential-expression-in-neuroblastoma-and-nephroblastoma
#3
Jerzy Klijanienko, Martial Caly, Paul Frénaux, Jan Klos
No abstract text is available yet for this article.
November 13, 2017: Cancer
https://www.readbyqxmd.com/read/29131532/reply-to-gata3-differential-expression-in-neuroblastoma-and-nephroblastoma
#4
Austin Blackburn Wiles, Celeste N Powers, Steven Christopher Smith
No abstract text is available yet for this article.
November 13, 2017: Cancer
https://www.readbyqxmd.com/read/29131258/correlation-of-rgs4-and-p16-expressions-with-pediatric-nephroblastoma-and-its-significance-on-prognosis
#5
X-X Liu, H-F Gong, X-X Zhao
OBJECTIVE: To investigate the correlation of regulator of G-protein signaling 4 (RGS4) and P16 expressions with pediatric nephroblastoma and its significance on prognosis. PATIENTS AND METHODS: A total of 80 children with primary nephroblastoma who underwent surgical resection in our hospital from March 2009 to March 2012 were selected as objects of study. The expressions of RGS4 and P16 in cancer and cancer-adjacent tissues of patients were detected by reverse transcription-polymerase chain reaction (RT-PCR), Western blot and immunohistochemistry...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29117360/racial-and-ethnic-disparities-in-the-incidence-of-pediatric-extracranial-embryonal-tumors
#6
Paola Friedrich, Elena Itriago, Carlos Rodriguez-Galindo, Karina Ribeiro
Background: Few studies have comparatively assessed differences in the incidence of childhood cancer by race and ethnicity that could inform etiologic research. We aimed to identify disparities in the incidence of pediatric extracranial embryonal tumors by race and ethnicity in the United States using a population-based cancer registry. Methods: Cases of extracranial embryonal tumors among children age 0 to 19 years diagnosed between 2000 and 2010 were retrieved from the Surveillance, Epidemiology, and End Results Program 18 (n = 8188)...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29081372/multiphoton-microscopy-a-novel-diagnostic-method-for-solid-tumors-in-a-prospective-pediatric-oncologic-cohort-an-experimental-study
#7
Oliver J Muensterer, Sibylle Waldron, Yoon Jung Boo, Claudius Ries, Lisa Sehls, Frank Simon, Larissa Seidmann, Jérôme Birkenstock, Jan Gödeke
BACKGROUND: The prognosis of solid pediatric tumors strongly correlates with accurate staging and complete local control. Currently, surgeons rely on macroscopic cues and intraoperative cryosection to determine resection borders. Multiphoton Microscopy (MPM) is a real time technique that allows imaging of tissue without time-consuming tissue processing. PURPOSE: This pilot study evaluates the diagnostic potential of MPM in pediatric solid tumors compared to routine histopathology...
October 30, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28933507/renal-neoplasia-in-horses-a-retrospective-study
#8
Julia Vienenkötter, Krystyna Siudak, Lena Stallenberger, Christiane Herden
OBJECTIVE: Being confronted with a case series of renal neoplasia in several horses which was in striking divergence to literature data, we recognized the need of a retrospective study to assess the presence of renal neoplasms in horses. MATERIAL AND METHODS: Anamnestic animal data, necropsy findings and results of histological and immunohistochemical examinations from 2010 through 2015 were collected and evaluated regarding renal neoplasia. RESULTS: Data from postmortem examinations of 1069 horses revealed 20 horses with renal tumors constituting a prevalence of 1...
September 20, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28903326/distinct-clinicopathological-features-in-metanephric-adenoma-harboring-braf-mutation
#9
Anna Caliò, John N Eble, Ondrej Hes, Guido Martignoni, Saul E Harari, Sean R Williamson, Matteo Brunelli, Adeboye O Osunkoya, Lisha Wang, Eva Comperat, Antonio Lopez-Beltran, Mingsheng Wang, Shaobo Zhang, Kendra L Curless, Kristin M Post, Hsim-Yee Chang, Claudio Luchini, Lee Ann Baldrige, Gregory T MacLennan, Rodolfo Montironi, David J Grignon, Liang Cheng
BRAF mutation recently has been reported in metanephric adenoma. We sought to determine the clinical and morphologic features of BRAF-mutated metanephric adenoma and to correlate BRAF mutation with BRAF V600E immunohistochemical staining results. A series of 48 metanephric adenomas and 15 epithelial-predominant nephroblastomas were analyzed for the occurrence of BRAF mutation (BRAF V600E/V600E complex, BRAF V600D, BRAF V600K and BRAF V600R) using the BRAF RGQ PCR kit (Qiagen). Immunohistochemistry was performed using monoclonal mouse antibodies against p16(INK4) and VE1 (Spring Bioscience), recognizing the BRAF V600E mutant protein...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900468/cancer-of-childhood-in-sub-saharan-africa
#10
REVIEW
Cristina Stefan, Freddie Bray, Jacques Ferlay, Biying Liu, D Maxwell Parkin
Measurement of incidence rates of childhood cancer in Africa is difficult. The study 'Cancer of Childhood in sub Saharan Africa' brings together results from 16 population-based registries which, as members of the African Cancer Registry Network (AFCRN), have been evaluated as achieving adequate coverage of their target population. The cancers are classified according to the third revision of the International Classification of Childhood Cancer (ICCC-3) and recorded rates in Africa are compared with those in childhood populations in the UK, France, and the USA...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28895096/palivizumab-prophylaxis-against-respiratory-syncytial-virus-infection-in-children-with-immunocompromised-conditions-or-down-syndrome-a-multicenter-post-marketing-surveillance-in-japan
#11
Tomoko Kashiwagi, Yukiko Okada, Ken Nomoto
OBJECTIVE: The aim of this study was to assess the safety and effectiveness of palivizumab for the prevention of lower respiratory tract infection (LRI) caused by respiratory syncytial virus (RSV) in children with immunocompromised conditions or Down syndrome. METHODS: In this multicenter, post-marketing surveillance study (December 2013 to December 2015), children aged ≤24 months with immunocompromised conditions or Down syndrome (without hemodynamically significant congenital heart disease) receiving palivizumab immunoprophylaxis during two RSV seasons were observed until 30 days after the final palivizumab injection...
September 11, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28818093/case-report-value-of-gene-expression-profiling-in-the-diagnosis-of-atypical-neuroblastoma
#12
Anne C Harttrampf, Qingrong Chen, Eva Jüttner, Julia Geiger, Gordon Vansant, Javed Khan, Udo Kontny
BACKGROUND: Nephroblastoma and neuroblastoma belong to the most common abdominal malignancies in childhood. Similarities in the initial presentation may provide difficulties in distinguishing between these two entities, especially if unusual variations to prevalent patterns of disease manifestation occur. Because of the risk of tumor rupture, European protocols do not require biopsy for diagnosis, which leads to misdiagnosis in some cases. CASE PRESENTATION: We report on a 4½-year-old girl with a renal tumor displaying radiological and laboratory characteristics supporting the diagnosis of nephroblastoma...
August 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28809783/role-of-omentin-vaspin-cardiotrophin-1-tweak-and-nov-ccn3-in-obesity-and-diabetes-development
#13
REVIEW
Xavier Escoté, Saioa Gómez-Zorita, Miguel López-Yoldi, Iñaki Milton-Laskibar, Alfredo Fernández-Quintela, J Alfredo Martínez, María J Moreno-Aliaga, María P Portillo
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28800310/nephroblastoma-overexpressed-gene-expression-and-its-prognostic-implications-of-clinical-outcomes-in-renal-cell-carcinoma-patients
#14
Hongbin Shi, Jianping Yu, Jie Li
BACKGROUND: The nephroblastoma overexpressed gene (NOV) expressions in tissues and organs has become abnormal during tumorigenesis and progression. This study intended to investigate the correlation between clinical outcomes and NOV expression in renal cell carcinoma (RCC) patients. METHODS: Fifty RCC patients who attended the hospital from January 2013 to January 2015 were enrolled in this study. NOV expression in cancerous tissues and adjacent non-tumor (ANT) renal tissues of RCC patients was detected by immunohistochemistry (IHC)...
September 7, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28798814/editorial-childhood-cancer-in-sub-saharan-africa
#15
EDITORIAL
Donald Maxwell Parkin, Cristina Stefan
Measurement of incidence rates of childhood cancer in Africa is difficult. The study 'Cancer of Childhood in sub Saharan Africa' [Stefan C, Bray F, Ferlay J, Parkin DM and Liu B (2017) Cancer of Childhood in sub-Saharan Africaecancer11(755)] brings together results from 16 population-based registries which, as members of the African Cancer Registry Network (AFCRN), have been evaluated as achieving adequate coverage of their target population. The cancers are classified according to the third revision of the International Classification of Childhood Cancer (ICCC-3) and recorded rates in Africa are compared with those in childhood populations in the UK, France, and the USA...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28798530/spontaneous-nephroblastoma-with-striated-muscle-differentiation-in-an-f344-rat
#16
Natsuki Tanaka, Takeshi Izawa, Jyoji Yamate, Mitsuru Kuwamura
An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nests, neoplastic cells with striations demonstrable by phosphotungstic acid hematoxylin were observed. Immunohistochemically, neoplastic stellate cells were partially positive for Wilms Tumor 1 and vimentin, and neoplastic cells with striations were partially positive for desmin...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28747915/t-cell-lymphoma-and-leukemia-in-severe-combined-immunodeficiency-pigs-following-bone-marrow-transplantation-a-case-report
#17
Ellis J Powell, Jared Graham, N M Ellinwood, Jesse Hostetter, Michael Yaeger, Chak-Sum Ho, Lynden Gault, Veronica Norlin, Elizabeth N Snella, Jackie Jens, Emily H Waide, Adeline N Boettcher, Maureen Kerrigan, Raymond R R Rowland, Jason W Ross, Jack C M Dekkers, Christopher K Tuggle
After the discovery of naturally occurring severe combined immunodeficiency (SCID) within a selection line of pigs at Iowa State University, we found two causative mutations in the Artemis gene: haplotype 12 (ART12) and haplotype 16 (ART16). Bone marrow transplants (BMTs) were performed to create genetically SCID and phenotypically immunocompetent breeding animals to establish a SCID colony for further characterization and research utilization. Of nine original BMT transfer recipients, only four achieved successful engraftment...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28728220/-diagnostic-utility-of-tyrosine-hydroxylase-in-peripheral-neuroblastic-tumors
#18
N Zhang, N Liu, L J He
Objective: To investigation the diagnostic utility of tyrosine hydroxylase (TH) immunohistochemically as a marker of peripheral neuroblastic tumors(pNT). Methods: The study included 1 024 cases, 643 primary and metastatic pNT cases, 381 non-pNT cases, including small round cell tumors such as primitive neuroectodermal tumor (PNET), rhabdomyosarcoma, lymphoma, nephroblastoma, as well as other more common tumors (medulloblastoma, hepatoblastoma, pleuropulmonary blastoma, renal clear cell sarcoma, Langerhans cell histiocytosis, lipoblatoma etc)...
July 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28707749/new-insights-into-sinusoidal-obstruction-syndrome
#19
Andrea Piccin, Maria Teresa Sartori, Gianni Bisogno, Muriel Van Schilfgaarde, Graziella Saggiorato, Angela Maria Di Pierro, Daisy Corvetta, Luigi Marcheselli, Mega Andrea, Günther Gastl, Simone Cesaro
We studied the relationships between endothelial extracellular vesicles (EV) and plasminogen-activator inhibitor type 1(PAI-1), to assess their modification in the early phase of sinusoidal obstruction syndrome (SOS). ENTRY CRITERIA: patients who developed SOS at single center from January 2000 to December 2011. SELECTION: patients who underwent hematopoietic stem cell transplantation (HSCT) or actinomicyn-based chemotherapy for nephroblastoma. PARTICIPANTS: the study group comprised 5 patients with SOS who were compared with a control group of 7 patients without SOS...
July 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28697171/variability-in-imaging-practices-and-comparative-cumulative-effective-dose-for-neuroblastoma-and-nephroblastoma-patients-at-6-pediatric-oncology-centers
#20
Baptiste Morel, Anne C Jaudeau-Collart, Maia Proisy, Louis M Leiber, Valentin Tissot, Marie P Quéré, Martine Mergy, Isabelle Pellier, Clara Vallin, Dominique Sirinelli
The purpose of this study was to estimate the cumulative effective dose (CED) from diagnosis and posttherapy computed tomographic (CT) scans performed on children treated for neuroblastoma or nephroblastoma (Wilms tumor) and to examine the different imaging practices used in 6 regional pediatric oncology centers between January 2010 and December 2013. We analyzed retrospectively the CT scan acquisition data in children aged 10 years or younger at diagnosis. The use of nonionizing imaging modalities was reported...
July 10, 2017: Journal of Pediatric Hematology/oncology
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