keyword
https://read.qxmd.com/read/38526609/nephroblastoma-specific-dysregulated-gene-snhg15-with-prognostic-significance-scrna-seq-with-bulk-rna-seq-data-and-experimental-validation
#1
JOURNAL ARTICLE
Mengmeng Chang, Ding Li, Li Su, Chen Ding, Zhiyi Lu, Hongjie Gao, Fengyin Sun
Wilms tumor (WT) is the most common malignancy of the genitourinary system in children. Currently, the Integration of single-cell RNA sequencing (scRNA-Seq) and Bulk RNA sequencing (RNA-Seq) analysis of heterogeneity between different cell types in pediatric WT tissues could more accurately find prognostic markers, but this is lacking. RNA-Seq and clinical data related to WT were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Small nucleolar RNA host gene 15 (SNHG15) was identified as a risk signature from the TARGET dataset by using weighted gene co-expression network analysis, differentially expressed analysis and univariate Cox analysis...
March 25, 2024: Discover. Oncology
https://read.qxmd.com/read/38524550/hypoxia-inflammation-induced-upregulation-of-hif-1%C3%AE-and-c-ebp%C3%AE-promotes-nephroblastoma-cell-emt-by-improving-hoxa11-as-transcription
#2
JOURNAL ARTICLE
Shibo Zhu, Rui Zhou, Xiangliang Tang, Wen Fu, Wei Jia
BACKGROUND: Homeobox (HOX) A11 antisense RNA (HOXA11-AS) has been identified as a cancer promoting lncRNA and is overexpressed in nephroblastoma. However, how HOXA11-AS is regulated in a hypoxic inflammatory environment has not been studied. METHODS: In this study, gene expression and epithelial-mesenchymal transition (EMT) ability were detected in the nephroblastoma cell line WiT49 under conditions of hypoxia and inflammation. Next, HOXA11-AS transcription factors were predicted by datasets and subsequently confirmed by CHIP-QPCR, EMSA, and dual-luciferase reporter assays...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508973/correlation-of-ct-scan-response-to-necrosis-and-volume-changes-with-histopathology-in-children-with-wilms-tumor
#3
JOURNAL ARTICLE
Niaz Nilave, Sajida Nahid, Saiyeda Karim, Shahnoor Islam, Amirul Morshed
BACKGROUND: Wilms' tumor is the most common renal tumor in children. OBJECTIVE: To correlate the percentage of necrosis and tumor volume change found in preoperative Contrast Enhance Computed Tomography (CECT) scan of the abdomen with post-operative histopathological findings of Wilms Tumor (WT). METHODS: In this prospective study from January 2020 to December 2022, out of 33 patients, 15 patients with unilateral localized WT (stage I, II, and III) treated according to SIOP UMBRELLA protocol 2016 were included...
February 27, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38495851/primary-testicular-teratoid-wilms-tumor-in-a-40-year-old-male-with-retroperitoneal-lymph-node-involvement-a-case-report
#4
Eylon J Arbel, Brian F Dinerman, John Rutkowski, Andrés M Acosta, Jeffrey Spencer
We report a 40-year-old male presenting with right testicular pain. Following right orchiectomy demonstrating pT1bS0N0M0 teratoma with extensive necrosis, the patient opted for surveillance. With new retroperitoneal lymphadenopathy, the patient underwent a robotic-assisted laparoscopic retroperitoneal lymph node. After final pathology demonstrated extensive necrosis, the initial orchiectomy specimen was re-reviewed which revealed 60/40 ratio of non-seminomatous teratoma to nephroblastoma. Adult presentation of testicular nephroblastoma is exceedingly rare and such reports contribute to the understanding of adult teratoid Wilms tumor pathogenesis...
March 2024: Urology Case Reports
https://read.qxmd.com/read/38488796/congenital-tooth-agenesis-and-risk-of-early-onset-cancer
#5
JOURNAL ARTICLE
Saga Elise Eiset, Jeremy Schraw, Gitte Vrelits Sørensen, Pernille Axél Gregersen, Sonja A Rasmussen, Cecilia H Ramlau-Hansen, Philip J Lupo, Henrik Hasle
IMPORTANCE: There is some evidence that tooth agenesis (congenital absence of 1 or more teeth) is associated with cancer risk, especially carcinomas of the colon and ovaries, but results of previous studies are conflicting, and associations have not yet been evaluated in a population-based setting. OBJECTIVE: To examine the association between tooth agenesis and specific cancer types before 40 years of age. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study used linking data from nationwide registries in Denmark to assess all Danish live-born singletons born from January 1, 1977, to December 31, 2018, and followed up for up to 40 years...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38482402/bilateral-wilms-tumor-10-year-experience-from-a-single-center-in-china
#6
JOURNAL ARTICLE
Wei Yao, Shuting Weng, Kai Li, Jian Shen, Rui Dong, Kuiran Dong
BACKGROUND: Nephron sparing surgery (NSS) had become the main surgical treatment for bilateral nephroblastoma. But it remained a challenge for surgeons to balance the dilemma between complete tumor resection to reduce tumor recurrence and renal parenchyma preservation to reduce end-stage renal disease (ESRD). In this study, we summarized our clinical experience for bilateral Wilms tumors managed in our center and evaluated the influence of different surgical approaches on prognosis. METHODS: The clinical data of patients with bilateral Wilms tumor in our hospital from January 2010 to December 2020 were retrospectively analyzed, and the clinical symptoms, surgical approaches and prognosis of the disease were summarized...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38460245/mirnas-role-in-wilms-tumor-pathogenesis-signaling-pathways-interplay
#7
REVIEW
Jaber Alfaifi
Wilms' tumors (WTs) are the most common type of kidney tumor in children, and a negative outlook is generally associated with widespread anaplastic. MicroRNAs (miRNAs) are crucial in the development of WT by regulating the expression of specific genes. There is an increasing amount of research that connects the dysregulation of miRNAs to the development of various renal illnesses. The conditions encompassed are renal fibrosis, renal cancers, and chronic and polycystic kidney disease. Dysregulation of several important miRNAs, either oncogenic or tumor-suppressing, has been found in WT...
March 5, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38427756/multicystic-renal-dysplasia-a-histomorphological-spectrum-seven-years-experience-from-a-tertiary-care-hospital
#8
JOURNAL ARTICLE
Kanika Gupta, Shramana Mandal, Varuna Mallya, Meeta Singh, Nita Khurana, Yogesh K Sarin
OBJECTIVES: Multicystic dysplastic kidney (MCDK) is defined as the presence of multiple noncommunicating cysts of various sizes, detected sonographically, without evidence of functioning renal parenchyma on dimercaptosuccinic acid renal scan. It has an incidence of 1:4000 live births. They are more commonly diagnosed in boys, usually on the left side, but may also be bilateral. There is the presence of primitive ducts surrounded by fibromuscular connective tissue. These are because of the disturbed connection of the ureteric bud with renal blastema and abnormal division at the stage of metanephros, resulting in an abnormal metanephros differentiation...
February 19, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38383003/suspected-renal-interstitial-cell-tumor-causing-polycythemia-in-two-dogs
#9
JOURNAL ARTICLE
Kaori Ide, Masaaki Katayama, Ikki Mitsui, Hiroshi Satoh, Ryuji Fukushima, Yoshio Yamamoto, Masahiro Yamasaki
Here we report a case series of two dogs diagnosed as renal interstitial cell tumor (RICT) accompanied by elevated serum erythropoietin level and marked polycythemia. RICT is a rare tumor in dogs, originating from renal interstitial cells. While several renal tumors such as renal lymphoma, adenocarcinoma, carcinoma, sarcoma, fibrosarcoma and nephroblastoma may cause polycythemia, polycythemia caused by RICT has never been reported in dogs. The tumors in both dogs were solitary and lied within cortex or cortico-medullary junction...
February 22, 2024: Journal of Veterinary Medical Science
https://read.qxmd.com/read/38365477/mechanism-of-lncrna-ftx-regulates-nephroblastoma-progression-through-mir-215-5p-pi3k-akt-axis
#10
JOURNAL ARTICLE
Li Wang, Qin Huang, Hui Li, Haisha Li, Xiangyun Wang, Xin Tan
BACKGROUND: Nephroblastoma, also more commonly known as Wilms tumor (WT), is a common childhood malignancy that connects tumorigenesis and organ development in the kidney. OBJECTIVE: The current study focused on the effect of lncRNA FTX in nephroblastoma. STUDY DESIGN: Expression of lncRNA FTX in nephroblastoma tissues and cells was determined. The expression location of lncRNA FTX was detected by FISH. The binding of lncRNA FTX and miR-215-5p with Ago2 was verified by RIP...
January 28, 2024: Journal of Pediatric Urology
https://read.qxmd.com/read/38334883/overexpression-of-aquaporin-1-plays-a-vital-role-in-proliferation-apoptosis-and-pyroptosis-of-wilms-tumor-cells
#11
JOURNAL ARTICLE
Hong Liu, Chen Jin, Nan Xia, Qian Dong
BACKGROUND: Nephroblastoma, also known as Wilms' tumor (WT), is an embryonic malignant tumor and one of the most common malignant tumors in the abdominal region of children. The exact role and underlying mechanisms of aquaporin-1 (AQP1) in the occurrence and development of nephroblastoma remain unclear. METHODS: After overexpression of AQP1, cell proliferation was assessed using the CCK-8 proliferation assay and EdU staining. Flow cytometry was employed to assess cell apoptosis, and Western blotting (WB) analysis was conducted to validate the expression of relevant protein markers...
February 9, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38310860/a-comprehensive-study-on-the-association-between-plasma-nov-ccn3-levels-and-insulin-resistance-in-childhood-obesity
#12
JOURNAL ARTICLE
Yuesheng Liu, Lijun Hao, Chunyan Yin, Min Li, Yanfeng Xiao
INTRODUCTION: Childhood obesity is a global health problem that is associated with various metabolic complications, such as insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. The mechanisms underlying the development of insulin resistance in childhood obesity are not fully understood. Nephroblastoma overexpressed gene (NOV), also known as CCN3, is a member of the CCN family of matricellular proteins that modulate cell proliferation, differentiation, adhesion, migration, and survival...
February 2, 2024: Annals of Nutrition & Metabolism
https://read.qxmd.com/read/38282073/wilms-tumour-resulting-from-paternal-transmission-of-a-trim28-pathogenic-variant-a-first-report
#13
JOURNAL ARTICLE
James Whitworth, Ruth Armstrong, Eamonn R Maher
Wilms tumour (nephroblastoma) is a renal embryonal tumour that is frequently caused by constitutional variants in a small range of cancer predisposition genes. TRIM28 has recently been identified as one such gene. Previously, observational data strongly suggested a parent of origin effect, whereby Wilms tumour only occurred following maternal inheritance of a pathogenic genetic variant. However, here we report a child with bilateral Wilms tumour who had inherited a pathogenic TRIM28 variant from their father...
January 29, 2024: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/38223903/bilateral-nephroblastomatosis-with-a-unilateral-wilms-tumor-a-case-report-highlighting-imaging-characteristics
#14
Amine Naggar, Saad Assila, Khadija Laasri, Hajar Andour, Zineb Izi, Najat Lamalmi, Siham El Haddad, Nazik Allali, Latifa Chat
Nephrogenic rests (NRs) are foci of embryonic nephrogenic cells that persist beyond the 36th week of gestation. They are precursor lesions of Wilms tumor and are found incidentally in approximately 1% of infants. The term nephroblastomatosis (NBS) is utilized when nephrogenic rests extensively or multifocally affect the kidneys. We report a case of a left nephroblastoma with bilateral nephroblastomatosis, treated with neoadjuvant chemotherapy followed by a left nephrectomy, highlighting the imaging features of nephrogenic rests on ultrasound, CT, and MRI, and the potential possibilities of distinguishing nephroblastomas from nephrogenic rests in one hand, and the possibilities of distinguishing active nephrogenic rests from inactive ones in the other hand...
2024: Global Pediatric Health
https://read.qxmd.com/read/38223339/single-cell-transcriptomes-of-kidneys-in-a-6-month-old-boy-with-denys-drash-syndrome-reveal-stromal-cell-heterogeneity-in-the-tumor-microenvironment
#15
JOURNAL ARTICLE
Tao Li, Jiangfeng Zhou, Haiyan Wu, Xiucheng Gao, Qiyang Shen, Rui Cheng, Mingshun Zhang
BACKGROUND: Denys-Drash syndrome (DDS) is a rare disease characterized with pseudohermaphroditism, nephroblastoma (also known as Wilms tumor), and diffuse mesangial sclerosis. The therapy for DDS is largely supportive, i.e. surgery and chemotherapy for Wilms tumor and renal replacement therapy. Due to the limited understanding of the pathogenesis, precision therapy for DDS is yet to be explored. We sought to explore the cellular components and interactions in kidney tissues from an infant with DDS...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38195816/multidimensional-transcriptomics-unveils-rnf34-as-a-prognostic-biomarker-and-potential-indicator-of-chemotherapy-sensitivity-in-wilms-tumour
#16
JOURNAL ARTICLE
Jie Zheng, Fengling Liu, Jinwei Tuo, Siyu Chen, Jinxia Su, Xiuyi Ou, Min Ding, Haoran Chen, Bo Shi, Yong Li, Xun Chen, Congjun Wang, Cheng Su
Nephroblastoma, colloquially known as Wilms' tumour (WT), is the predominant malignant renal neoplasm arising in the paediatric population. Modern therapeutic approaches for WT incorporate a synergistic combination of surgical intervention, radiotherapy, and chemotherapy, which substantially ameliorate the overall patient survival rate. Despite this, the optimal sequence of chemotherapy and surgical intervention remains a matter of contention, with each strategy presenting its own strengths and weaknesses that could influence clinical decision-making...
January 9, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38184433/characteristics-and-clinical-outcomes-of-children-with-wilms-tumour-a-15-year-experience-in-a-single-centre-in-nigeria
#17
JOURNAL ARTICLE
Abdulrasheed A Nasir, Nurudeen T Abdur-Raheem, Lukman O Abdur-Rahman, Taibat T Ibiyeye, Tolulope O Sayomi, Olanrewaju T Adedoyin, James O Adeniran
BACKGROUND: Wilms' tumor (WT) is the most common paediatric renal tumor and is one of the most treatment-responsive solid tumours. Survival from Wilms tumour (WT) in sub-Saharan Africa remains dismal as a result of late presentation, treatment abandonment and infrastructure deficit. The purpose of this study was to analyze the clinical outcome of children with Wilms tumour managed in a Nigerian referral centre over a 15-year period. METHODS: This is a retrospective study of children with WT (nephroblastoma) who were treated at our institution between January 2006 and December 2020...
December 16, 2023: Journal of Pediatric Surgery
https://read.qxmd.com/read/38180141/a-rare-case-of-extrarenal-wilms-tumor-of-the-uterine-corpus-comprehensive-genomic-profile-and-review-of-the-literature
#18
Lara Alessandrini, Angela Guerriero, Giada Munari, Biancamaria Del Forno, Luisa Santoro, Matteo Marchetti, Margherita Nardin, Roberto Tozzi, Matteo Fassan, Angelo Paolo Dei Tos
Wilms tumor (WT), or nephroblastoma, is an uncommon malignant neoplasm occurring in the kidney of pediatric patients. Its extrarenal location is extremely rare and has been reported in various sites, including the female genital tract, with only 9 cases arising in the uterine corpus. We present the case of an adult woman who underwent total abdominal hysterectomy due to a uterine mass causing persistent abdominal pain. The characteristic triphasic morphology (composed of epithelial, stromal, and blastemal elements) supported by a broad immunohistochemical panel, along with the imaging exclusion of a renal neoplasm, was diagnostic of WT of the uterus...
December 2023: Pathologica
https://read.qxmd.com/read/38137540/altered-red-blood-cell-fatty-acid-and-serum-adipokine-profiles-in-subjects-with-obesity
#19
JOURNAL ARTICLE
Asier Léniz, Alfredo Fernández-Quintela, Sara Arranz, Kevin Portune, Itziar Tueros, Eunate Arana, Luis Castaño, Olaia Velasco, María P Portillo
BACKGROUND: Adipokines, as well as the fatty acid profile of red blood cell (RBC) membranes, are known to play important roles in the development and progression of metabolic complications induced by obesity. Thus, the objective of this study is to compare the serum adipokine profile and the RBC membrane fatty acid profile of normal-weight and obese adults, and to analyze their relationship with serum biochemical parameters. METHODS: An observational case-control study was performed in 75 normal-weight and obese adult subjects...
December 15, 2023: Biomedicines
https://read.qxmd.com/read/38098581/cystic-partially-differentiated-nephroblastoma-in-an-18-month-old-girl-a-case-report
#20
Alia Alhassoun, Albaraa H Bara, Mohammad N Ibrahim, Selman M Berro, Mays G Khalil
INTRODUCTION AND IMPORTANCE: Cystic partially differentiated nephroblastoma (CPDN) is a rare cystic tumor that affects the kidney. It has a low potential for malignancy. It usually presents as an abdominal mass. It may be difficult to confirm the diagnosis of CPDN without a histopathological study. CASE PRESENTATION: The authors report a case of an 18-month-old girl with abdominal distention, which was noticed by her parents. An abdominal computed tomography scan showed a large multilocular cystic mass arising from the lower pole of the left kidney...
December 2023: Annals of Medicine and Surgery
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