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https://www.readbyqxmd.com/read/28928151/comparative-analysis-reveals-genomic-features-of-stress-induced-transcriptional-readthrough
#1
Anna Vilborg, Niv Sabath, Yuval Wiesel, Jenny Nathans, Flonia Levy-Adam, Therese A Yario, Joan A Steitz, Reut Shalgi
Transcription is a highly regulated process, and stress-induced changes in gene transcription have been shown to play a major role in stress responses and adaptation. Genome-wide studies reveal prevalent transcription beyond known protein-coding gene loci, generating a variety of RNA classes, most of unknown function. One such class, termed downstream of gene-containing transcripts (DoGs), was reported to result from transcriptional readthrough upon osmotic stress in human cells. However, how widespread the readthrough phenomenon is, and what its causes and consequences are, remain elusive...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28915393/the-comparative-effectiveness-of-noninvasive-and-invasive-ventilation-in-patients-with-pneumonia
#2
Mihaela S Stefan, Aruna Priya, Penelope S Pekow, Tara Lagu, Jay S Steingrub, Nicholas S Hill, Brian H Nathanson, Peter K Lindenauer
PURPOSE: To compare the outcomes of patients hospitalized with pneumonia treated with noninvasive ventilation (NIV) and invasive mechanical ventilation (IMV). MATERIALS AND METHODS: Using the HealthFacts multihospital electronic medical record database, we included patients hospitalized with a diagnosis of pneumonia and treated with NIV or IMV. We developed a propensity model for receipt of initial NIV and assessed the outcomes in a propensity-matched cohort, and in a covariate adjusted and propensity score weighted models...
May 23, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28910298/adult-hippocampal-neurogenesis-poststroke-more-new-granule-cells-but-aberrant-morphology-and-impaired-spatial-memory
#3
Florus Woitke, Mihai Ceanga, Max Rudolph, Fanny Niv, Otto W Witte, Christoph Redecker, Albrecht Kunze, Silke Keiner
Stroke significantly stimulates neurogenesis in the adult dentate gyrus, though the functional role of this postlesional response is mostly unclear. Recent findings suggest that newborn neurons generated in the context of stroke may fail to correctly integrate into pre-existing networks. We hypothesized that increased neurogenesis in the dentate gyrus following stroke is associated with aberrant neurogenesis and impairment of hippocampus-dependent memory. To address these questions we used the middle cerebral artery occlusion model (MCAO) in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28905152/a-controlled-trial-to-reduce-the-risk-of-human-nipah-virus-exposure-in-bangladesh
#4
Nazmun Nahar, Repon C Paul, Rebeca Sultana, Shariful Amin Sumon, Kajal Chandra Banik, Jaynal Abedin, Mohammad Asaduzzaman, Fernando Garcia, Susan Zimicki, Mahmudur Rahman, Emily S Gurley, Stephen P Luby
Human Nipah virus (NiV) infection, often fatal in Bangladesh, is primarily transmitted by drinking raw date palm sap contaminated by Pteropus bats. We assessed the impact of a behavior change communication intervention on reducing consumption of potentially NiV-contaminated raw sap. During the 2012-2014 sap harvesting seasons, we implemented interventions in two areas and compared results with a control area. In one area, we disseminated a "do not drink raw sap" message and, in the other area, encouraged only drinking sap if it had been protected from bat contamination by a barrier ("only safe sap")...
September 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/28900720/respiration-related-cerebral-blood-flow-variability-increases-during-control-mode-non-invasive-ventilation-in-normovolemia-and-hypovolemia
#5
Maria Skytioti, Signe Søvik, Maja Elstad
PURPOSE: Increased variability in cerebral blood flow (CBF) predisposes to adverse cerebrovascular events. Oscillations in arterial blood pressure and PaCO2 induce CBF variability. Less is known about how heart rate (HR) variability affects CBF. We experimentally reduced respiration-induced HR variability in healthy subjects, hypothesizing that CBF variability would increase. METHODS: Internal carotid artery (ICA) blood velocity was recorded by Doppler ultrasound in ten healthy subjects during baseline, control-mode, non-invasive mechanical ventilation (NIV), i...
September 12, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28891333/profile-of-medical-care-costs-in-patients-with-amyotrophic-lateral-sclerosis-in-the-medicare-programme-and-under-commercial-insurance
#6
Lisa Meng, Amy Bian, Scott Jordan, Andrew Wolff, Jeremy M Shefner, Jinsy Andrews
OBJECTIVE: To determine amyotrophic lateral sclerosis (ALS)-associated costs incurred by patients covered by Medicare and/or commercial insurance before, during and after diagnosis and provide cost details. METHODS: Costs were calculated from the Medicare Standard Analytical File 5% sample claims data from Parts A and B from 2009, 2010 and 2011 for ALS Medicare patients aged ≥70 years (monthly costs) and ≥65 years (costs associated with disability milestones)...
September 11, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28889939/erratum-to-immunohistochemistry-staining-for-mismatch-repair-proteins-the-endoscopic-biopsy-material-provides-useful-and-coherent-results-hum-pathol-2015-46-1705-1711
#7
Alex Vilkin, Ya'ara Leibovici-Weissman, Marisa Halpern, Sara Morgenstern, Eli Brazovski, Rachel Gingold-Belfer, Nir Wasserberg, Baruch Brenner, Yaron Niv, Orly Sneh-Arbib, Zohar Levi
No abstract text is available yet for this article.
September 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28884567/high-peak-pao2-values-are-associated-with-adverse-outcome-in-critically-ill-patients-treated-with-non-invasive-ventilation-for-acute-cardogenic-pulmonary-edema-and-pneumonia
#8
Christiana Schernthaner, Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Alexander Lauten, Paul C Schulze, Bjoern Kabisch, Kristina Braun, Johanna Muessig, Maryna Masyuk, Uta C Hoppe, Malte Kelm, Christian Jung
BACKGROUND: Non-invasive Ventilation (NIV) has a sigificant impact on mortality in acute respiratory failure (ARF). Predictive parameters for mortality are of high interest. METHODS: We retrospectively analyzed 3759 blood gas analysis and clinical parameters of 475 patients presenting with ARF based on acute cardiogenic pulmonary edema and/or pneumonia. The influence of peak arterial oxygen partial pressure levels (PaO2) with respect to its predictive value for in-hopital and long-term mortality was investigated...
September 7, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28875324/-extreme-obesity-particular-aspect-of-invasive-and-noninvasive-ventilation
#9
REVIEW
M Deppe, P Lebiedz
The obesity rate is increasing worldwide and the percentage of obese patients in the intensive care unit (ICU) is rising concomitantly. Ventilatory support strategies in obese patients must take into account the altered pathophysiological conditions. Unfortunately, prospective randomized multicenter trials on this subject are lacking. Therefore, current strategies are based on the individual experiences of ICU physicians and single-center studies. Noninvasive ventilation (NIV) in critically ill patients with acute respiratory failure and obesity hypoventilation syndrome (OHS) is an efficient treatment option and should be provided as early as possible is an effort to avoid intubation...
September 5, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28870157/ten-important-articles-on-noninvasive-ventilation-in-critically-ill-patients-and-insights-for-the-future-a-report-of-expert-opinions
#10
A Cortegiani, V Russotto, M Antonelli, E Azoulay, A Carlucci, G Conti, A Demoule, M Ferrer, N S Hill, S Jaber, P Navalesi, P Pelosi, R Scala, C Gregoretti
BACKGROUND: Noninvasive ventilation is used worldwide in many settings. Its effectiveness has been proven for common clinical conditions in critical care such as cardiogenic pulmonary edema and chronic obstructive pulmonary disease exacerbations. Since the first pioneering studies of noninvasive ventilation in critical care in the late 1980s, thousands of studies and articles have been published on this topic. Interestingly, some aspects remain controversial (e.g. its use in de-novo hypoxemic respiratory failure, role of sedation, self-induced lung injury)...
September 4, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28870127/major-liver-resection-in-pregnancy-three-cases-with-different-etiologies-and-review-of-the-literature
#11
M D Niv Pencovich, Muhammad Younis, Yonatan Lessing, Lilach Zac, Joseph B Lessing, M D Yariv Yogev, Michael J Kupferminc, Ido Nachmany
BACKGROUND: Major liver resection during pregnancy is extremely rare. When required, the associated physiologic and anatomic changes pose specific challenges and greater risk for both mother and fetus Materials and methods: Three cases of major liver resection during pregnancy due to different etiologies are presented. The relevant literature is reviewed and discussed. RESULTS: We present 3 cases of major liver resection due to giant liver hemangioma with Kasabach-Merrit syndrome, giant hydatid cyst, and intrahepatic cholangiocarcinoma, at gestational week (GW) 17, 19, and 30, respectively...
September 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28860265/official-ers-ats-clinical-practice-guidelines-noninvasive-ventilation-for-acute-respiratory-failure
#12
Bram Rochwerg, Laurent Brochard, Mark W Elliott, Dean Hess, Nicholas S Hill, Stefano Nava, Paolo Navalesi, Massimo Antonelli, Jan Brozek, Giorgio Conti, Miquel Ferrer, Kalpalatha Guntupalli, Samir Jaber, Sean Keenan, Jordi Mancebo, Sangeeta Mehta, Suhail Raoof
Noninvasive mechanical ventilation (NIV) is widely used in the acute care setting for acute respiratory failure (ARF) across a variety of aetiologies. This document provides European Respiratory Society/American Thoracic Society recommendations for the clinical application of NIV based on the most current literature.The guideline committee was composed of clinicians, methodologists and experts in the field of NIV. The committee developed recommendations based on the GRADE (Grading, Recommendation, Assessment, Development and Evaluation) methodology for each actionable question...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28860127/the-haptoglobin-1-1-genotype-modulates-the-association-of-glycemic-control-with-hippocampal-volume-in-elderly-with-type-2-diabetes
#13
Abigail Livny, Ramit Ravona-Springer, Anthony Heymann, Rachel Priess, Tammar Kushnir, Galia Tsarfaty, Leeron Rabinov, Reut Moran, Niv Tik, Erin Moshier, Itzik Cooper, Lior Greenbaum, Jeremy Silverman, Andrew Levy, Mary Sano, Barbara B Bendlin, Aron S Buchman, Michal Schnaider Beeri
Recent evidence suggests that glycemic control is associated with cognitive function in older patients with type 2 diabetes (T2D) carriers of Haptoglobin (Hp) 1-1 genotype compared to non-carriers. We assessed whether poor glycemic control in Hp 1-1 carriers is more strongly associated with smaller hippocampal volume than in non-carriers.Hippocampal volume was generated from high-resolution structural T1 MR-imaging obtained for 224 participants (28 Hp 1-1 carriers [12.5%] and 196 non-carriers [87.5%]) from the Israel Diabetes and Cognitive Decline study, who had a mean number of years in the MHS registry of 8...
August 31, 2017: Diabetes
https://www.readbyqxmd.com/read/28844407/novel-hemagglutinin-nanoparticle-influenza-vaccine-with-matrix-m%C3%A2-adjuvant-induces-hemagglutination-inhibition-neutralizing-and-protective-responses-in-ferrets-against-homologous-and-drifted-a-h3n2-subtypes
#14
Gale Smith, Ye Liu, David Flyer, Michael J Massare, Bin Zhou, Nita Patel, Larry Ellingsworth, Maggie Lewis, James F Cummings, Greg Glenn
Influenza viruses frequently acquire mutations undergoing antigenic drift necessitating annual evaluation of vaccine strains. Highly conserved epitopes have been identified in the hemagglutinin (HA) head and stem regions, however, current influenza vaccines induce only limited responses to these conserved sites. Here, we describe a novel seasonal recombinant HA nanoparticle influenza vaccine (NIV) formulated with a saponin-based adjuvant, Matrix-M™. NIV induced hemagglutination inhibition (HAI) and microneutralizing (MN) antibodies against a broad range of influenza A(H3N2) subtypes...
September 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28843985/laparoscopic-sleeve-gastrectomy-for-diabetics-5-year-outcomes
#15
Yonatan Lessing, Niv Pencovich, Guy Lahat, Joseph M Klausner, Subhi Abu-Abeid, Shai Meron Eldar
OBJECTIVE: Although the laparoscopic sleeve gastrectomy (SG) is increasingly performed for morbid obesity, gastric bypass is still considered by many to be the gold standard procedure for obese diabetic patients. The aim of this study was to assess the long-term results of SG in morbidly obese patients with type 2 diabetes. METHODS: Diabetic patients who underwent SG at a single center between 2009 and 2011 were included. Outcomes assessed included postoperative complications, weight loss, and resolution or improvement in co-morbidities with an emphasis on diabetes, including glycated hemoglobin (HbA1C) and medication status...
July 18, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28840631/domiciliary-non-invasive-ventilation-post-lung-transplantation
#16
Sakhee Kotecha, Catherine Buchan, Kerry Parker, Jo Toghill, Eldho Paul, Belinda Miller, Matthew Naughton, Gregory Snell, Eli Dabscheck
BACKGROUND AND OBJECTIVE: The benefits of domiciliary non-invasive ventilation (NIV) post lung transplantation (LTx) have not previously been described. This was a single-centre retrospective audit of patients requiring domiciliary NIV post-LTx. Our aim was to describe indications for NIV and outcomes in chronic lung allograft dysfunction (CLAD) and diaphragmatic palsy. METHODS: All patients requiring domiciliary NIV post-LTx between 2010 and June 2016 were assessed...
August 24, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28840025/development-of-acute-parotitis-after-non-invasive-ventilation
#17
Eduardo Martinez, Peter V Dicpinigaitis
A 90-year-old woman underwent laparoscopic exploratory laparotomy for evaluation of suspected mesenteric ischemia. She was promptly extubated postoperatively and transferred to the intensive care unit, where on the first postoperative day she developed hypoxemia necessitating initiation of noninvasive ventilation (NIV) with bilevel positive airway pressure (BiPAP). After 8 hours of BiPAP, she was noted to have swelling, erythema and tenderness in the right preauricular area. Ultrasound evaluation demonstrated an enlarged right parotid gland...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28839496/use-of-nasal-non-invasive-ventilation-with-a-ram-cannula-in-the-outpatient-home-setting
#18
Wilfredo De Jesus Rojas, Cheryl L Samuels, Traci R Gonzales, Katrina E McBeth, Aravind Yadav, James M Stark, Cindy Jon, Ricardo A Mosquera
BACKGROUND: Nasal non-invasive-ventilation (Nasal NIV) is a mode of ventilatory support providing positive pressure to patients via a nasal interface. The RAM Cannula is an oxygen delivery device that can be used as an alternative approach to deliver positive pressure. Together they have been successfully used to provide respiratory support in neonatal in-patient settings. OBJECTIVE: To describe the outpatient use of Nasal NIV/RAM Cannula as a feasible alternative for home respiratory support in children with chronic respiratory failure...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28839495/survival-of-hypercapnic-patients-with-copd-and-obesity-hypoventilation-syndrome-treated-with-high-intensity-non-invasive-ventilation-in-the-daily-routine-care
#19
Thomas Blankenburg, Christin Benthin, Stefanie Pohl, Anett Bramer, Frank Kalbitz, Christine Lautenschläger, Wolfgang Schütte
BACKGROUND: Home ventilation is an effective treatment option for obesity hypoventilation syndrome (OHS). This therapy is still controversial for stable chronic obstructive pulmonary disease (COPD). A recent study showed reduced mortality for COPD patients receiving home ventilation with high inflation pressures and back-up respiratory rates [so called High Intensity non-invasive ventilation (NIV)]. OBJECTIVE: The purpose of this study is whether High Intensity NIV applied in the routine care of COPD and OHS patients can lead to CO2 reduction and survival data comparable to data from controlled studies...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28835499/nipah-and-hendra-virus-nucleoproteins-inhibit-nuclear-accumulation-of-stat1-and-stat2-by-interfering-with-their-complex-formation
#20
Akihiro Sugai, Hiroki Sato, Ikuyo Takayama, Misako Yoneda, Chieko Kai
Henipaviruses, such as Nipah (NiV) and Hendra (HeV) viruses, are highly pathogenic zoonotic agents within the Paramyxoviridae family. The phosphoprotein (P) gene products of the paramyxoviruses have been well characterized in their interferon (IFN) antagonist activity and their contribution to viral pathogenicity. In this study, we demonstrated that the nucleoprotein (N) of henipaviruses also prevents the host IFN signaling pathway. Reporter assays demonstrated that NiV and HeV N proteins (NiV-N and HeV-N, respectively) suppressed both type-I and type-II IFN responses dose-dependently, and the inhibitory effect was mediated by their core-domains...
August 23, 2017: Journal of Virology
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