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https://www.readbyqxmd.com/read/28231020/could-niv-failure-rates-be-underestimated-in-the-lung-safe-study
#1
Rémi Coudroy, Jean-Pierre Frat, Arnaud W Thille
No abstract text is available yet for this article.
February 23, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28230848/computational-approaches-to-fmri-analysis
#2
Jonathan D Cohen, Nathaniel Daw, Barbara Engelhardt, Uri Hasson, Kai Li, Yael Niv, Kenneth A Norman, Jonathan Pillow, Peter J Ramadge, Nicholas B Turk-Browne, Theodore L Willke
Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis...
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28229023/toxgen-an-improved-reference-database-for-the-identification-of-type-b-trichothecene-genotypes-in-fusarium
#3
Tomasz Kulik, Kessy Abarenkov, Maciej Buśko, Katarzyna Bilska, Anne D van Diepeningen, Anna Ostrowska-Kołodziejczak, Katarzyna Krawczyk, Balázs Brankovics, Sebastian Stenglein, Jakub Sawicki, Juliusz Perkowski
Type B trichothecenes, which pose a serious hazard to consumer health, occur worldwide in grains. These mycotoxins are produced mainly by three different trichothecene genotypes/chemotypes: 3ADON (3-acetyldeoxynivalenol), 15ADON (15-acetyldeoxynivalenol) and NIV (nivalenol), named after these three major mycotoxin compounds. Correct identification of these genotypes is elementary for all studies relating to population surveys, fungal ecology and mycotoxicology. Trichothecene producers exhibit enormous strain-dependent chemical diversity, which may result in variation in levels of the genotype's determining toxin and in the production of low to high amounts of atypical compounds...
2017: PeerJ
https://www.readbyqxmd.com/read/28224729/management-of-hypoxaemic-respiratory-failure-in-a-respiratory-high-dependency-unit
#4
Craig Hukins, Mimi Wong, Michelle Murphy, John Upham
BACKGROUND: There are limited data on outcomes of hypoxaemic respiratory failure (HRF), especially in non-ICU settings. AIM: To assess outcomes in HRF (without multi-system disease and not requiring early intubation) directly admitted to a Respiratory High Dependency Unit (R-HDU). METHODS: Retrospective, cohort study of HRF compared to Hypercapnic Respiratory Failure (HCRF) in a R-HDU (2007-2011). Patient characteristics (age, gender, pre-morbid status, diagnoses) and outcomes (non-invasive ventilation (NIV) use, survival, ICU admission) were assessed...
February 22, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28221721/esogastric-pressure-measurement-to-assist-noninvasive-ventilation-indication-and-settings-in-infants-with-hypercapnic-respiratory-failure-a-pilot-study
#5
Guillaume Mortamet, Sonia Khirani, Alessandro Amaddeo, Guillaume Emeriaud, Sylvain Renolleau, Brigitte Fauroux
OBJECTIVE: Noninvasive ventilation (NIV) in usually set on clinical parameters. The aim of the study was to assess the value of esophageal (PES ) and gastric pressure (PGAS ) measurements for the indication and optimal settings of NIV in infants with hypercapnic respiratory failure in whom the efficacy of NIV was uncertain on clinical noninvasive parameters. DESIGN: A retrospective study. PATIENT-SUBJECT SELECTION: PES and PGAS measurements were performed in seven infants <2 years old admitted in the Pediatric Intensive Care Unit for an acute or acute-on-chronic hypercapnic respiratory failure...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28218802/non-invasive-ventilation-for-cystic-fibrosis
#6
REVIEW
Fidelma Moran, Judy M Bradley, Amanda J Piper
BACKGROUND: Non-invasive ventilation may be a means to temporarily reverse or slow the progression of respiratory failure in cystic fibrosis by providing ventilatory support and avoiding tracheal intubation. Using non-invasive ventilation, in the appropriate situation or individuals, can improve lung mechanics through increasing airflow and gas exchange and decreasing the work of breathing. Non-invasive ventilation thus acts as an external respiratory muscle. This is an update of a previously published review...
February 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28216104/high-flow-nasal-cannula-therapy-versus-non-invasive-ventilation-in-children-with-severe-acute-asthma-exacerbation-an-observational-cohort-study
#7
J Pilar, V Modesto I Alapont, Y M Lopez-Fernandez, O Lopez-Macias, D Garcia-Urabayen, I Amores-Hernandez
INTRODUCTION: The present study describes our experience with the high-flow humidified nasal cannula (HFNC) versus non-invasive ventilation (NIV) in children with severe acute asthma exacerbation (SA). METHODS: An observational study of a retrospective cohort of 42 children with SA admitted to a Pediatric Intensive Care Unit (PICU) for non-invasive respiratory support was made. The primary outcome measure was failure of initial respiratory support (need to escalate from HFNC to NIV or from NIV to invasive ventilation)...
February 16, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28208797/multi-mycotoxin%C3%A2-analysis%C3%A2-in%C3%A2-durum%C3%A2-wheat%C3%A2-pasta%C3%A2-by%C3%A2-liquid%C3%A2-chromatography%C3%A2-coupled%C3%A2-to%C3%A2-quadrupole%C3%A2-orbitrap%C3%A2-mass%C3%A2-spectrometry
#8
Josefa Tolosa, Giulia Graziani, Anna Gaspari, Donato Chianese, Emilia Ferrer, Jordi Mañes, Alberto Ritieni
A simple and rapid multi-mycotoxin method for the determination of 17 mycotoxins  simultaneously  is  described  in  the  present  survey  on  durum  and  soft  wheat  pasta  samples.  Mycotoxins included in the study were those mainly reported in cereal samples: ochratoxin-A  (OTA), aflatoxin B1 (AFB1), zearalenone (ZON), deoxynivalenol (DON), 3-and 15-acetyl-deoxynivalenol  (3-AcDON and 15-AcDON), nivalenol (NIV), neosolaniol (NEO), fusarenon-X, (FUS-X), T-2 toxin  (T-2) and HT-2 toxin (HT-2), fumonisin B1 and B2 (FB1 and FB2), and four emerging mycotoxins:  three  enniatins  (ENA,  ENA1,  and  ENB),  and  beauvericin  (BEA)...
February 9, 2017: Toxins
https://www.readbyqxmd.com/read/28207474/risk-of-colectomy-in-patients-with-pediatric-onset-ulcerative-colitis
#9
Firas Rinawi, Amit Assa, Rami Eliakim, Yael Mozer Glassberg, Vered Nachmias Friedler, Yaron Niv, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
OBJECTIVES: Data describing the incidence and risk factors for colectomy in pediatric ulcerative colitis (UC) is inconsistent. Our aim was to describe the colectomy rate and to identify risk factors associated with colectomy in a large cohort of children with UC with long term follow up. METHODS: We performed a retrospective chart review of pediatric UC cases that were diagnosed at Schneider Children's Medical Center of Israel between 1981 to 2013. Potential predictors for colectomy including age at diagnosis, gender, disease extent, severity indices and different therapeutic regimens during disease course were assessed...
February 15, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28203623/pyoderma-gangrenosum-acne-and-hidradenitis-suppurativa-pash-syndrome-with-recurrent-vasculitis
#10
Dorene Niv, James A Ramirez, David P Fivenson
No abstract text is available yet for this article.
January 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28195019/do-you-see-the-forest-or-the-tree-neural-gain-and-breadth-versus-focus-in-perceptual-processing
#11
Eran Eldar, Yael Niv, Jonathan D Cohen
When perceiving rich sensory information, some people may integrate its various aspects, whereas other people may selectively focus on its most salient aspects. We propose that neural gain modulates the trade-off between breadth and selectivity, such that high gain focuses perception on those aspects of the information that have the strongest, most immediate influence, whereas low gain allows broader integration of different aspects. We illustrate our hypothesis using a neural-network model of ambiguous-letter perception...
December 2016: Psychological Science
https://www.readbyqxmd.com/read/28192893/non-invasive-ventilation-improves-respiratory-distress-in-children-with-acute-viral-bronchiolitis-a-systematic-review
#12
Yann Combret, Guillaume Prieur, Pascal LE Roux, Clément Médrinal
BACKGROUND: Non-invasive ventilation (NIV) is a common treatment for bronchiolitis. However, consensus concerning its efficacy is lacking. The aim of this systematic review was to assess NIV effectiveness to reduce respiratory distress. Secondary objectives were to summarize the effects of NIV, identify predictive factors for failure and describe settings and applications. METHODS: Searches were conducted in MEDLINE Pubmed, PEDro, COCHRANE, EMBASE, CINAHL, Web of Science, Up-todate and Sudoc from 1990 to April 2015...
February 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28181069/quality-of-life-and-uncertainty-in-crohn-s-disease
#13
Galia Niv, Simona Bar Josef, Ofer Ben Bassat, Irit Avni, Lev Lictenstein, Yaron Niv, Sivia Barnoy
INTRODUCTION: Crohn's disease impairs patients' perception of health and has a negative impact on health-related quality of life. Although it is apparent that uncertainty is a significant factor that decreases quality of life, it has never been studied in patients with Crohn's disease. The objective of the present study was to examine the association between level of certainty, self-epistemic authority, Internet information gathering habits, and health-related quality of life. METHODS: A cross-sectional study of 105 Crohn's disease patients was conducted...
February 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28174526/reconsolidation-extinction-interactions-in-fear-memory-attenuation-the-role-of-inter-trial-interval-variability
#14
Allison Auchter, Lawrence K Cormack, Yael Niv, Francisco Gonzalez-Lima, Marie H Monfils
Fear extinction typically results in the formation of a new inhibitory memory that suppresses the original conditioned response. Evidence also suggests that extinction training during a retrieval-induced labile period results in integration of the extinction memory into the original fear memory, rendering the fear memory less susceptible to reinstatement. Here we investigated the parameters by which the retrieval-extinction paradigm was most effective in memory updating. Specifically, we manipulated the inter-trial intervals (ITIs) between conditional stimulus (CS) presentations during extinction, examining how having interval lengths with different degrees of variability affected the strength of memory updating...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28173049/p708-helicobacter-pylori-and-ibd-are-inversely-related-suggesting-that-individuals-infected-with-the-bacteria-are-less-susceptible-to-the-disease
#15
L Lichtenstein, D Boltin, H Leibovici, T Tsadok Perets, I Avni, D Comaneshter, Y Leibovici-Weissman, A Cohen, Y Niv, Z Levi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169831/design-principles-of-autocatalytic-cycles-constrain-enzyme-kinetics-and-force-low-substrate-saturation-at-flux-branch-points
#16
Uri Barenholz, Dan Davidi, Eduard Reznik, Yinon Bar-On, Niv Antonovsky, Elad Noor, Ron Milo
A set of chemical reactions that require a metabolite to synthesize more of that metabolite is an autocatalytic cycle. Here we show that most of the reactions in the core of central carbon metabolism are part of compact autocatalytic cycles. Such metabolic designs must meet specific conditions to support stable fluxes, hence avoiding depletion of intermediate metabolites. As such, they are subjected to constraints that may seem counter-intuitive: the enzymes of branch reactions out of the cycle must be overexpressed and the affinity of these enzymes to their substrates must be relatively weak...
February 7, 2017: ELife
https://www.readbyqxmd.com/read/28166828/a-psychological-intervention-to-promote-acceptance-and-adherence-to-non-invasive-ventilation-in-people-with-chronic-obstructive-pulmonary-disease-study-protocol-of-a-randomised-controlled-trial
#17
Eleonora Volpato, Paolo Banfi, Francesco Pagnini
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) sometimes experience anxiety, depression and comorbid cognitive deficits. Rather than being merely a consequence of symptom-related physical impairments these additional problems may be part of the clinical course of the condition. The relationship between the physical and psychological aspects of the condition is illustrated by the patterns of use of non-invasive ventilation (NIV); NIV is often rejected or used inappropriately, resulting in clinical deterioration and an increase in health care costs...
February 6, 2017: Trials
https://www.readbyqxmd.com/read/28158267/trends-in-assisted-ventilation-and-outcome-for-obstructive-pulmonary-disease-exacerbations-a-nationwide-study
#18
Anne Pernille Toft-Petersen, Christian Torp-Pedersen, Ulla Møller Weinreich, Bodil Steen Rasmussen
BACKGROUND: Non-invasive ventilation (NIV) has been used for decades in treatment of exacerbations of chronic obstructive pulmonary disease (COPD). The impact of the changing use of assisted ventilation in acute exacerbations on outcomes has not been fully elucidated and we aimed to describe these changes in the Danish population and describe their consequences for mortality. METHODS: A register-based study was conducted of a cohort of 12,847 patients admitted for acute exacerbation of COPD (AECOPD) from 2004 through 2011, treated with invasive mechanical ventilation (IMV) or NIV for the first time...
2017: PloS One
https://www.readbyqxmd.com/read/28153465/-prevention-and-treatment-of-skin-lesions-associated-with-non-invasive-mechanical-ventilation-recommendations-of-experts
#19
M Raurell-Torredà, A Romero-Collado, M Rodríguez-Palma, M Farrés-Tarafa, J D Martí, B Hurtado-Pardos, L Peñarrubia-San Florencio, P Saez-Paredes, A M Esquinas
INTRODUCTION: In the last two decades, non-invasive mechanical ventilation (NIV) has been consolidated as an initial strategy for the management of respiratory failure in critical adult and paediatric patients. OBJECTIVES: To identify risk factors and preventive strategies to reduce the incidence of skin lesions associated with clinical devices (LESADIC) related to NIV, as well as the most effective treatment for injuries that cannot be avoided. METHODOLOGY: Review in the MEDLINE, CINAHL and Cochrane databases of studies published in the last 10years to reach consensus through an expert panel...
January 30, 2017: Enfermería Intensiva
https://www.readbyqxmd.com/read/28152689/comparative-effectiveness-research-in-renal-cell-carcinoma-lenvatinib-with-everolimus-as-a-potential-new-treatment-option
#20
Corey Pelletier, Unnati Majethia, Anna Forsythe
: 27 Background: Renal cell carcinoma (RCC) is the most common type of kidney cancer and represents about 90% of all kidney cancers. As comprehensive comparison of the efficacy associated with mRCC treatments is not available, the goal of this research was to provide a comparative effectiveness analysis including overall survival (OS) and progression free survival (PFS) for first and second line treatments. METHODS: Systematic literature review yielded the following randomized active-controlled studies: lenvatinib + everolimus (LEN+EVE) versus everolimus (EVE), axinitib (AXI) versus sorafenib (SOR), cabozantinib (CAB) versus EVE, nivolumab (NIV) versus EVE, and pazopanib (PAZ) versus sunitinib (SUN)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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