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https://www.readbyqxmd.com/read/29163844/identifying-current-and-remitted-major-depressive-disorder-with-the-hurst-exponent-a-comparative-study-on-two-automated-anatomical-labeling-atlases
#1
Bin Jing, Zhuqing Long, Han Liu, Huagang Yan, Jianxin Dong, Xiao Mo, Dan Li, Chunhong Liu, Haiyun Li
Major depressive disorder (MDD) is a leading world-wide psychiatric disorder with high recurrence rate, therefore, it is desirable to identify current MDD (cMDD) and remitted MDD (rMDD) for their appropriate therapeutic interventions. In the study, 19 cMDD, 19 rMDD and 19 well-matched healthy controls (HC) were enrolled and scanned with the resting-state functional magnetic resonance imaging (rs-fMRI). The Hurst exponent (HE) of rs-fMRI in AAL-90 and AAL-1024 atlases were calculated and compared between groups...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29157726/adaptive-and-technology-independent-architecture-for-fault-tolerant-distributed-aal-solutions
#2
Michael Schmidt, Roman Obermaisser
Today's architectures for Ambient Assisted Living (AAL) must cope with a variety of challenges like flawless sensor integration and time synchronization (e.g. for sensor data fusion) while abstracting from the underlying technologies at the same time. Furthermore, an architecture for AAL must be capable to manage distributed application scenarios in order to support elderly people in all situations of their everyday life. This encompasses not just life at home but in particular the mobility of elderly people (e...
November 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29153863/assessment-of-uranium-release-to-the-environment-from-a-disabled-uranium-mine-in-brazil
#3
Wagner de Souza Pereira, Alphonse Germaine Albert Charles Kelecom, Ademir Xavier da Silva, Alessander Sá do Carmo, Delcy de Azavedo Py Júnior
The Ore Treatment Unit (in Portuguese Unidade de Tratamento de Minérios - UTM) located in Caldas, MG, Brazil is a disabled uranium mine. Environmental conditions generate acid drainage leaching metals and radionuclides from the waste rock pile. This drainage is treated to remove the heavy metals and radionuclides, before allowing the release of the effluent to the environment. To validate the treatment, samples of the released effluents were collected at the interface of the installation with the environment...
November 16, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29147635/global-and-targeted-pathway-impact-of-gliomas-on-white-matter-integrity-based-on-lobar-localization
#4
David R Ormond, Shawn D'Souza, John A Thompson
Primary brain tumors comprise 28% of all tumors and 80% of malignant tumors. Pathophysiology of high-grade gliomas includes significant distortion of white matter architecture, necrosis, the breakdown of the blood brain barrier, and increased intracranial pressure. Diffusion tensor imaging (DTI), a diffusion weighted imaging technique, can be used to assess white matter architecture. Use of DTI as a non-invasive pathophysiological tool to analyze glioma impact on white matter microstructure has yet to be fully explored...
September 7, 2017: Curēus
https://www.readbyqxmd.com/read/29137174/hdomo-smart-sensor-integration-for-an-active-and-independent-longevity-of-the-elderly
#5
Emanuele Frontoni, Rama Pollini, Paola Russo, Primo Zingaretti, Graziano Cerri
The aim of this paper is to present the main results of HDOMO, an Ambient Assisted Living (AAL) project that involved 16 Small and Medium Enterprises (SMEs) and 2 research institutes. The objective of the project was to create an autonomous and automated domestic environment, primarily for elderly people and people with physical and motor disabilities. A known and familiar environment should help users in their daily activities and it should act as a virtual caregiver by calling, if necessary, relief efforts...
November 13, 2017: Sensors
https://www.readbyqxmd.com/read/29130773/alteration-of-salivary-glycopatterns-in-oral-lichen-planus
#6
Liang Fang, Qing Liu, Pengfei He, Xinwen Wang, Ying Wang, Minghui Wei, Lihua Chen
BACKGROUND: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Structural changes in the glycans of saliva proteins might be reliable indicators of OLP. However, little is known about the alteration of salivary glycopatterns during OLP. OBJECTIVE: We aimed to investigate the alterations of salivary protein glycosylation related to OLP...
November 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29118535/rapid-versus-gradual-bladder-decompression-in-acute-urinary-retention
#7
Mohamed H Etafy, Fatma H Saleh, Cervando Ortiz-Vanderdys, Alaa Hamada, Alaa M Refaat, Mohamed Abdel Aal, Hazem Deif, Maher Gawish, Ashraf H Abdellatif, Khaled Gadalla
Objective: To demonstrate a benefit in diminished adverse events such as hypotension and hematuria with gradual drainage of the bladder when compared to rapid decompression in patients with acute urinary retention (AUR) due to benign prostatic hyperplasia in a case-control study. Methods: Sixty-two patients matched our selection criteria presenting with AUR. They were divided into two groups - the first was managed by rapid drainage of the bladder, the second was managed by gradual drainage through a urethral catheter (The first 100 mL immediately evacuated, then the rest evacuated gradually over 2 h)...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29114976/a-comparative-study-of-viral-capsids-and-bacterial-microcompartments-reveals-an-enriched-understanding-of-shell-dynamics
#8
Guang Song
In this work, we carry out a comparative study of the homo 360-mer structures of viral capsids and bacterial micro-compartments (MCPs). Different from viral 360-mers that all are arranged on a skewed right-handed icosahedral lattice with a triangulation number T of 7, the new 360-mer structure of AaLS-13, an engineered bacterial micro-compartment, offers a novel open conformation that has a unique unskewed lattice arrangement with a triangulation number T of 1 and large keyhole-shaped pores in the shell. By comparing their differences, we are able to predict a closed conformation of AaLS-13 that has the same lattice arrangement as existing viral capsid structures and in which all the keyhole-shaped pores are shut...
November 7, 2017: Proteins
https://www.readbyqxmd.com/read/29111250/river-sediment-quality-assessment-using-sediment-quality-indices-for-the-sydney-basin-australia-affected-by-coal-and-coal-seam-gas-mining
#9
Aal-E Ali, Vladimir Strezov, Peter J Davies, Ian Wright
Coal mining activities in the Sydney basin have been historically associated with significant environmental impacts. The region is facing more recent coal seam gas extraction activities and the synergetic environmental impacts of the new mining activities are still largely unknown. The aim of this study was to provide environmental assessment of river sediments comparing upstream to downstream areas relative to industrial-discharge sites associated with coal and coal-seam-gas extraction within the Sydney basin...
October 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29103837/persistent-pulmonary-arteriovenous-malformations-percutaneous-embolotherapy
#10
Ahmed Kamel Abdel Aal, Joseph Eason, Sherif Moawad, Khalid Mahmoud, Basant Farouk Hamed, Moustafa Omar Massoud, Nathan Ertel, Andrew Gunn, Rachel Oser, Souheil Saddekni
Pulmonary arteriovenous malformations (PAVM) are an uncommon entity that interventional radiologists may face in their clinical practice. Many of these lesions are treated successfully using endovascular techniques with satisfactory long-term results. However, some PAVMs respond poorly to initial interventional techniques. This article reviews the signs and symptoms of persistent PAVMs, illustrates different imaging modalities used to diagnose these lesions, and outlines mechanisms by which these lesions may persist...
September 21, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29081748/coq10-augments-rosuvastatin-neuroprotective-effect-in-a-model-of-global-ischemia-via-inhibition-of-nf-%C3%AE%C2%BAb-jnk3-bax-and-activation-of-akt-foxo3a-bim-cues
#11
Sarah A Abd El-Aal, Mai A Abd El-Fattah, Hanan S El-Abhar
Statins were reported to lower the Coenzyme Q10 (CoQ10) content upon their inhibition of HMG-CoA reductase enzyme and both are known to possess neuroprotective potentials; therefore, the aim is to assess the possible use of CoQ10 as an adds-on therapy to rosuvastatin to improve its effect using global I/R model. Rats were allocated into sham, I/R, rosuvastatin (10 mg/kg), CoQ10 (10 mg/kg) and their combination. Drugs were administered orally for 7 days before I/R. Pretreatment with rosuvastatin and/or CoQ10 inhibited the hippocampal content of malondialdehyde, nitric oxide, and boosted glutathione and superoxide dismutase...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29077528/effects-of-recombinant-agrocybe-aegerita-lectin-as-an-immunoadjuvant-on-immune-responses
#12
Li-Bao Ma, Bao-Yang Xu, Min Huang, Qi-Gai He
CONTEXT: Accumulated evidence has indicated that recombinant Agrocybe aegerita lectin (AAL) possesses immunoadjuvant activity to enhance antigen-specific immune responses. However, the mechanism of how AAL regulates immune response remains poorly defined. AIM: This study is aimed to reveal the mechanism of AAL's immunoadjuvant activity. METHODS: In this study, AAL alone or combined with inactivated avian influenza virus H9N2 was immunized to mice and the transcriptome profile of immunized mice was analyzed...
October 27, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29071762/combination-of-carvacrol-with-simvastatin-improves-the-lipid-lowering-efficacy-and-alleviates-simvastatin-side-effects
#13
Hayat A Abd El Aal, Lamiaa A Ahmed, Wedad A Hassan, Hala M Fawzy, Helmy Moawad
The present investigation was designed to examine the possible additive hypolipidemic effect of carvacrol (CARV) in combination with simvastatin (SIM) on poloxamer 407 (P407)-induced hyperlipidemia. Rats were injected with P407,(500 mg/ kg; i.p.), twice a week, for 30 days. Treatment was carried out by administration of SIM (20 mg/kg/day; p.o.) or CARV (50 mg/kg/day; p.o.) or combination of them. Treatment with CARV significantly decreased total cholesterol, triglycerides, low-density lipoprotein, atherogenic index, leptin, and increased high-density lipoprotein and adiponectin...
October 26, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29071210/identifying-motor-functional-neurological-disorder-using-resting-state-functional-connectivity
#14
Jennifer Wegrzyk, Valeria Kebets, Jonas Richiardi, Silvio Galli, Dimitri Van de Ville, Selma Aybek
BACKGROUND: Motor functional neurological disorder (mFND) is a clinical diagnosis with reliable features; however, patients are reluctant to accept the diagnosis and physicians themselves bear doubts on potential misdiagnoses. The identification of a positive biomarker could help limiting unnecessary costs of multiple referrals and investigations, thus promoting early diagnosis and allowing early engagement in appropriate therapy. OBJECTIVES: To test whether resting-state (RS) functional magnetic resonance imaging could discriminate patients suffering from mFND from healthy controls...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29070767/genotoxic-effects-of-occupational-exposure-to-benzene-in-gasoline-station-workers
#15
Eman Salem, Islam El-Garawani, Heba Allam, Bahiga Abd El-Aal, Mofreh Hegazy
Benzene, a hazardous component of gasoline, is a genotoxic class I human carcinogen. This study evaluated the genotoxic effects of occupational exposure to benzene in gasoline stations. Genotoxicity of exposure to benzene was assessed in peripheral blood leucocytes of 62 gasoline station workers and compared with an equal numbers of matched controls using total genomic DNA fragmentation, micronucleus test and cell viability test. An ambient air samples were collected and analyzed for Monitoring of benzene, toluene, ethyl benzene and xylene (BTEX) in work environment and control areas...
October 25, 2017: Industrial Health
https://www.readbyqxmd.com/read/29058413/mining-high-complexity-motifs-in-glycans-a-new-language-to-uncover-the-fine-specificities-of-lectins-and-glycosidases
#16
Zachary Klamer, Ben Staal, Anthony R Prudden, Lin Liu, David F Smith, Geert-Jan Boons, Brian Haab
Knowledge of lectin and glycosidase specificities is fundamental to the study of glycobiology. The primary specificities of such molecules can be uncovered using well-established tools, but the complex details of their specificities are difficult to determine and describe. Here we present a language and algorithm for the analysis and description of glycan motifs with high complexity. The language uses human-readable notation and wildcards, modifiers, and logical operators to define motifs of nearly any complexity...
November 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29038711/study-of-the-c677t-and-1298ac-polymorphic-genotypes-of-mthfr-gene-in-autism-spectrum-disorder
#17
Farida El-Baz, Mohammed Abd El-Aal, Tarek Moustafa Kamal, Abdelrahim Abdrabou Sadek, Amr Ahmed Othman
BACKGROUND: Autism is currently known as "a behaviorally defined syndrome" manifested as impairment in social communication, repetitive routines and restricted interests. There is an increased risk of ASDs associated with common mutations affecting the folate/methylation cycle. AIM: The aim of this study was to identify C677T and 1298AC polymorphic genotypes of MTHFR gene among a sample of Egyptian children with autism and to make a phenotype-genotype correlation for the autistic patients...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29037782/paeoniflorin-targets-apoptosis-and-ameliorates-fibrosis-in-murine-schistosomiasis-mansoni-a-novel-insight
#18
Naglaa Fathy Abd El-Aal, Rania Said Hamza, Ola Harb
Schistosomiasis is a chronic helminthic disease causing hepatic fibrosis. Some studies demonstrated direct effect of targeting apoptosis on fibrosis regression. This study is a novel trial of Paeoniflorin (PAE) on S. mansoni induced hepatic fibrosis in murine model compared to Praziquantel (PZQ) evaluating their anti-parasitic and anti-fibrotic properties aiming to discover a new therapy that decrease schistosomiasis morbidity. Thirty two laboratory bred Swiss albino male CD-1 mice were used in this study...
October 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29035850/anti-angiogenic-and-anti-lymphangiogenic-role-of-praziquantel-and-artemether-in-experimental-mansoniasis
#19
Naglaa Fathy Abd El-Aal, Rania Said Hamza, Mona Magdy
Angiogenesis is one of the pillars of neoplasia. Lymphangiogenesis in context of granulomas is not yet understood. This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management. Forty female CD-1 Swiss albino mice were used divided into 4 groups (10 mice each); control healthy, control infected untreated, PZQ-treated and ART-treated...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29033826/everyday-functioning-benefits-from-an-assisted-living-platform-amongst-frail-older-adults-and-their-caregivers
#20
Lucile Dupuy, Charlotte Froger, Charles Consel, Hélène Sauzéon
Ambient assisted living technologies (AAL) are regarded as a promising solution to support aging in place. Yet, their efficacy has to be demonstrated in terms of benefits for independent living and for work conditions of caregivers. Hence, the purpose of this study was to assess the benefits of a multi-task AAL platform for both Frail older Individuals (FIs) and professional caregivers with respect to everyday functioning and caregiver burden. In this context, a 6-month field study involved 32 FIs living at home (half of them were equipped by the platform and the remaining half were not, as a control condition) and their caregivers...
2017: Frontiers in Aging Neuroscience
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