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https://www.readbyqxmd.com/read/28520865/impact-of-an-integrated-antibiotic-allergy-testing-program-on-antimicrobial-stewardship-a-multicenter-evaluation
#1
Jason A Trubiano, Karin A Thursky, Andrew J Stewardson, Karen Urbancic, Leon J Worth, Cheryl Jackson, Wendy Stevenson, Michael Sutherland, Monica A Slavin, M Lindsay Grayson, Elizabeth J Phillips
Background.: Despite the high prevalence of patient-reported antibiotic allergy (so-called antibiotic allergy labels [AALs]) and their impact on antibiotic prescribing, incorporation of antibiotic allergy testing (AAT) into antimicrobial stewardship (AMS) programs (AAT-AMS) is not widespread. We aimed to evaluate the impact of an AAT-AMS program on AAL prevalence, antibiotic usage, and appropriateness of prescribing. Methods.: AAT-AMS was implemented at two large Australian hospitals during a 14-month period beginning May 2015...
May 18, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28515315/the-c-terminal-peptide-of-aquifex-aeolicus-riboflavin-synthase-directs-encapsulation-of-native-and-foreign-guests-by-a-cage-forming-lumazine-synthase
#2
Yusuke Azuma, Reinhard Zschoche, Donald Hilvert
Encapsulation of specific enzymes in self-assembling protein cages is a hallmark of bacterial compartments that function as counterparts to eukaryotic organelles. The cage-forming enzyme lumazine synthase (LS) from Bacillus subtilis (BsLS), for example, encapsulates riboflavin synthase (BsRS), enabling channeling of lumazine from the site of its generation to the site of its conversion to vitamin B2. Elucidating the molecular mechanisms underlying the assembly of these supramolecular complexes could help inform new approaches for metabolic engineering, nanotechnology, and drug delivery...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28509333/altered-glycan-accessibility-on-native-immunoglobulin-g-complexes-in-early-rheumatoid-arthritis-and-its-changes-during-therapy
#3
Judith Stümer, Mona H C Biermann, Jasmin Knopf, Iryna Magorivska, Alf Kastbom, Anna Svärd, Christina Janko, Rostyslav Bilyy, Georg Schett, Christopher Sjöwall, Martin Herrmann, Luis E Muñoz
The goal of this study was to investigate the glycosylation profile of native IgG present in serum immune complexes in patients with rheumatoid arthritis (RA). To accomplish this, lectin binding assays, detecting the accessibility of glycans present on IgG-containing immune complexes by biotinylated lectins were employed. Lectins capturing fucosyl residues (AAL), fucosylated tri-mannose N-glycan core sites (LCA), terminal sialic acid residues (SNA) and O-glycosidically-linked galactose/N-acetylgalactosamine (GalNac-L) were used...
May 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28508807/new-service-excellence-model-for-ehealth-and-aal-solutions-a-framework-for-continuous-new-service-development
#4
Johannes Kriegel, Luise Reckwitz, Klemens Auinger, Linda Tuttle-Weidinger, Stephanie Schmitt-Rüth, Renate Kränzl-Nagl
The development of eHealth and AAL (Ambient Assisted Living) services with the aim to reduce the complexity of living environments for the elderly often does not lead to the desired results on the market. The design of an eHealth/AAL specific framework for continuous New Service Development is presented in this paper. Our research addresses this challenge with a new Service Excellence Model (SEM) and outlines the benefits of this specific approach. The research is based on the data of the DALIA project (Assistant for DAily LIfe Activities at Home) and the PenAAL project (Performance Measurement Index for AAL solutions), parts of which the projects were the classification of relevant business dimensions and the development of a related scoring tool for continuous benchmarking and improvement...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28508795/assistive-solutions-in-practice-experiences-from-aal-pilot-regions-in-austria
#5
Nesrin Ates, Georg Aumayr, Mario Drobics, Kristina Maria Förster, Christopher Frauenberger, Markus Garschall, Manfred Kofler, Daniela Krainer, Johannes Kropf, Kurt Majcen, Johannes Oberzaucher, Felix Piazolo, Angelika Rzepka, Julia Sauskojus, Cornelia Schneider, Andreas Stainer-Hochgatterer, Nadine Sturm, Uli Waibel, Viktoria Willner
Since 2012 six AAL pilot regions were launched in Austria. The main goal of these pilot regions is to evaluate the impact of AAL technologies in daily use considering the entire value chain. Additionally, go-to market strategies for assistive technologies based on an involvement of all relevant stakeholders are developed. Within this paper an overview of the specific objectives, approaches and the status of all Austrian AAL pilot regions is given. Taking into account the different experiences of the different pilot regions, specific challenges in establishing, implementing and sustaining pilot region projects are discussed and lessons-learned are presented...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28481304/roles-of-glycoproteins-in-the-diagnosis-and-differential-diagnosis-of-chronic-and-latent-keshan-disease
#6
Sen Wang, Zheng Fan, Bing Zhou, Yingting Wang, Peiru Du, Wuhong Tan, Mikko J Lammi, Xiong Guo
We aimed to explore the roles of glycoproteins in the pathogenesis of chronic and latent Keshan disease (CKD and LKD), and screen the lectins as indicators of significant differences in glycoproteins of KD saliva and serum. Blood and saliva were collected from 50 CKD, 50 LKD patients and 54 normal individuals. Saliva and serum lectin microarrays and saliva and serum microarrays were used to screen and verify the differences in the levels of lectin among the three groups. In the male saliva lectin microarray, Solanum tuberosum (potato) lectin (STL) and other 9 lectins showed differences between CKD and normal; STL and other 9 lectins showed differences between LKD and normal; Aleuria aurantia lectin (AAL) and other 15 lectins showed differences between CKD and LKD...
May 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28479556/wearable-and-mobile-technology-for-safe-and-active-living
#7
Mette Røhne, Elin Sundby Boysen, Dag Ausen
The study explores how mobile safety alarms can be utilized for ambient assisted living (AAL), and provides elderly safety, autonomy, independence and mobility. The aim is to generate knowledge on usage, usability and technical requirements to harvest the potential benefits of using wearable and mobile technologies in care for safe and active living. The study is based on real life pilots in three Norwegian municipalities with 71 users, their caregivers and relatives. Pilot users wore the mobile safety alarm while performing their daily activities - indoor and outdoor...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28472609/diagnosis-of-afp-negative-early-stage-hepatocellular-carcinoma-using-fuc-pon1
#8
Hong Shu, Wei Li, Shuxin Shang, Xue Qin, Shu Zhang, Yinkun Liu
Our previous study demonstrated that Fuc-PON1 (the ratio of fucosylated serum paraoxonase 1 to the total serum serum paraoxonase 1) was increased significantly in hepatocellular carcinoma (HCC) patients with low AFP levels. Herein, a separate cohort of AFP-negative (AFP(-)) early HCC patients was studied to validate the diagnostic potential of Fuc-PON1. Aleuria aurantia lectin (AAL) ELISA and protein ELISA were measured simultaneously to calculate PON1 fucosylation at its protein level. Lens culinaris agglutinin reactive AFP (AFP-L3) and glypican-3 (GPC3) concentrations of the same specimens were also evaluated...
March 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28449464/the-role-of-bioglue-in-thoracic-surgery-a-systematic-review
#9
Diamantis I Tsilimigras, Aspasia Antonopoulou, Ioannis Ntanasis-Stathopoulos, Davide Patrini, Kostas Papagiannopoulos, David Lawrence, Nikolaos Panagiotopoulos
BACKGROUND: BioGlue is a commonly used sealant in thoracic surgery. Prolonged air leak and presence of bronchopleural fistulae (BPF) are often encountered in clinical practice. We therefore, investigated the role and the efficacy of BioGlue in these scenarios. METHODS: A systematic review was conducted by searching Medline [1966-2016] and Cochrane Central Register of Controlled Trials (CENTRAL) [1999-2016] along with reference lists of the included studies. Included studies reported on thoracic surgery operations and use of BioGlue in thoracic surgical procedures, whereas excluded studies met at least one of the following criteria: non-English language studies, non-human population, studies on surgical specialties other than Thoracic surgery, reviews and meta-analyses and sealants other than BioGlue...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28436541/pdx1-mody-and-dorsal-pancreatic-agenesis-new-phenotype-of-a-rare-disease
#10
L A Caetano, L S Santana, A D Costa-Riquetto, A M Lerario, M Nery, G F Nogueira, C D Ortega, M S Rocha, Aal Jorge, M G Teles
Maturity-Onset Diabetes of the Young (MODY) type 4 or PDX1-MODY is a rare form of monogenic diabetes caused by heterozygous variants in PDX1. Pancreatic developmental anomalies related to PDX1 are reported only in neonatal diabetes cases. Here, we describe dorsal pancreatic agenesis in two patients with PDX1-MODY. The proband presented with diabetes since 14 years of age and maintained regular glycemic control with low doses of basal insulin and detectable C-peptide levels after 30 years with diabetes. A diagnosis of MODY was suspected...
April 24, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28423749/monitoring-activities-related-to-medication-adherence-in-ambient-assisted-living-environments
#11
Patrice C Roy, Samina Raza Abidi, Syed Sibte Raza Abidi
A recent trend in healthcare is to motivate patients to self-manage their health conditions in home-based settings. Medication adherence is an important aspect in disease self-management since sub-optimal medication adherence by the patient can lead to serious healthcare costs and discomfort for the patient. In order to alleviate the limitations of self-reported medication adherence, we can use ambient assistive living (AAL) technologies in smart environments. Activity recognition services allow to retrieve self-management information related to medication adherence in a less intrusive way...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28406459/homesound-real-time-audio-event-detection-based-on-high-performance-computing-for-behaviour-and-surveillance-remote-monitoring
#12
Rosa Ma Alsina-Pagès, Joan Navarro, Francesc Alías, Marcos Hervás
The consistent growth in human life expectancy during the recent years has driven governments and private organizations to increase the efforts in caring for the eldest segment of the population. These institutions have built hospitals and retirement homes that have been rapidly overfilled, making their associated maintenance and operating costs prohibitive. The latest advances in technology and communications envisage new ways to monitor those people with special needs at their own home, increasing their quality of life in a cost-affordable way...
April 13, 2017: Sensors
https://www.readbyqxmd.com/read/28394268/fusing-bluetooth-beacon-data-with-wi-fi-radiomaps-for-improved-indoor-localization
#13
Loizos Kanaris, Akis Kokkinis, Antonio Liotta, Stavros Stavrou
Indoor user localization and tracking are instrumental to a broad range of services and applications in the Internet of Things (IoT) and particularly in Body Sensor Networks (BSN) and Ambient Assisted Living (AAL) scenarios. Due to the widespread availability of IEEE 802.11, many localization platforms have been proposed, based on the Wi-Fi Received Signal Strength (RSS) indicator, using algorithms such as K-Nearest Neighbour (KNN), Maximum A Posteriori (MAP) and Minimum Mean Square Error (MMSE). In this paper, we introduce a hybrid method that combines the simplicity (and low cost) of Bluetooth Low Energy (BLE) and the popular 802...
April 10, 2017: Sensors
https://www.readbyqxmd.com/read/28387724/analysis-and-tools-for-improved-management-of-connectionless-and-connection-oriented-ble-devices-coexistence
#14
Antonio Del Campo, Lorenzo Cintioni, Susanna Spinsante, Ennio Gambi
With the introduction of low-power wireless technologies, like Bluetooth Low Energy (BLE), new applications are approaching the home automation, healthcare, fitness, automotive and consumer electronics markets. BLE devices are designed to maximize the battery life, i.e., to run for long time on a single coin-cell battery. In typical application scenarios of home automation and Ambient Assisted Living (AAL), the sensors that monitor relatively unpredictable and rare events should coexist with other sensors that continuously communicate health or environmental parameter measurements...
April 7, 2017: Sensors
https://www.readbyqxmd.com/read/28374431/characteristics-of-intrabony-nerve-canals-in-mandibular-interforaminal-region-by-using-cone-beam-computed-tomography-and-a-recommendation-of-safe-zone-for-implant-and-bone-harvesting
#15
Xiang-Wen Yang, Fei-Fei Zhang, Yi-Han Li, Bin Wei, Yao Gong
BACKGROUND: Cone-beam computed tomography can accurately show anatomic structure of intrabony nerve canals in mandibular interforaminal region. PURPOSE: The aim was to evaluate the characteristics of intrabony nerve canals in mandibular interforaminal region by using cone-beam computed tomography (CBCT) and determine a safe zone for implant and bone harvesting. MATERIALS AND METHODS: Hemimandibles (824) CBCT images were obtained. The length of the anterior loop (AL), the length and diameter of the mandibular incisive canal (MIC) and its spatial distance in various landmarks were measured...
February 3, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28363248/the-resting-state-functional-magnetic-resonance-imaging-regional-homogeneity-metrics-kendall-s-coefficient-of-concordance-regional-homogeneity-and-coherence-regional-homogeneity-are-valid-indicators-of-tumor-related-neurovascular-uncoupling
#16
Shruti Agarwal, Haris I Sair, Jay J Pillai
The aim of this study is to determine whether regional homogeneity (ReHo) of resting-state blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (rsfMRI) data based on Kendall's coefficient of concordance (KCC-ReHo) and coherence (Cohe-ReHo) metrics may allow detection of brain tumor-induced neurovascular uncoupling (NVU) in the sensorimotor network similar to findings in standard motor task-based BOLD fMRI (tbfMRI) activation. Twelve de novo brain tumor patients undergoing clinical fMRI exams (tbfMRI and rsfMRI) were included in this Institutional Review Board (IRB)-approved study...
May 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28362557/chemoembolization-of-hepatocellular-carcinoma-with-extrahepatic-collateral-blood-supply-anatomic-and-technical-considerations
#17
Amr Soliman Moustafa, Ahmed Kamel Abdel Aal, Nathan Ertel, Nael Saad, Derek DuBay, Souheil Saddekni
Transarterial chemoembolization (TACE) is considered a standard local-regional treatment for intermediate-stage hepatocellular carcinoma (HCC) and the most common bridging therapy. This treatment is offered to more than 70% of patients who are on the waiting list for liver transplantation in the United States. HCC typically receives its blood supply from the hepatic artery; however, it can recruit a parasitic supply from extrahepatic collateral (EHC) arteries. The development of an EHC arterial blood supply can interfere with the therapeutic efficacy of TACE and result in treatment failure and poor outcome...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28325476/erectile-dysfunction-in-patients-with-nonalcoholic-fatty-liver-disease
#18
Ahmad Farooq Alsayed Hasanain, Reem Ezzat Mahdy, Ali Mohamed Abdel-Rahman Mahran, Ahmed Serag Mahmoud Safwat, Asmaa Omar Mohamed, Sherif Mohamed Abdel-Aal
BACKGROUND AND STUDY AIMS: There is a lack of studies on erectile dysfunction (ED) in patients diagnosed with nonalcoholic fatty liver disease (NAFLD). The present study aimed to estimate the prevalence of ED in patients with NAFLD and to determine the independent predictors of ED in these patients. PATIENTS AND METHODS: We conducted a prospective, hospital-based study of 192 consecutive male patients with NAFLD. All patients underwent clinical evaluation; abdominal ultrasonography; test for viral hepatitis markers; and estimation of liver chemistry panel, complete blood count, prothrombin time, serum lipids panel, serum testosterone, and fasting serum levels of glucose, insulin, and C-peptide...
March 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28301993/outcome-of-living-donor-liver-transplant-for-hepatocellular-carcinoma-15-year-single-center-experience-in-egypt
#19
Refaat Kamel, Yaser Hatata, Karim Hosny, Ahmed Nabil, Alaa El-Deen Abd-Allah, Aaser Mostafa, Amr Abdel-Aal, Mahmoud Z Elganzoury, Osama Elmalt, Ibrahim Marwan, Adel Hosny
OBJECTIVES: Liver transplant performed for hepatocellular carcinoma must adhere to criteria for the size and number of focal hepatic lesions to lower the incidence of recurrence and achieve survival rates comparable to patients transplanted for other indications. Since the Milan criteria were established in 1996, there have been many less restrictive criteria yielding similar results. Our aim was to identify the prognostic factors for patient survival and for recurrence of hepatocellular carcinoma for patients within and beyond the Milan criteria...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28296934/reverse-lectin-elisa-for-detecting-fucosylated-forms-of-%C3%AE-1-acid-glycoprotein-associated-with-hepatocellular-carcinoma
#20
Eva Åström, Per Stål, Robin Zenlander, Pia Edenvik, Catharina Alexandersson, Mats Haglund, Ingvar Rydén, Peter Påhlsson
Altered fucosylation of glycoproteins is associated with development of hepatocellular carcinoma (HCC). Lectins have been commonly used to assay changes in fucosylation of plasma glycoproteins. In the present study a recombinantly engineered form of the fucose binding lectin Aleuria aurantia (AAL) consisting of a single binding site for fucose (S2), was used to construct a reverse lectin ELISA method. Microtiter plates coated with the S2 lectin were used to capture glycoproteins from plasma samples followed by antibody detection of S2-bound fucosylated α1-acid glycoprotein (S2-bound AGP)...
2017: PloS One
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