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https://www.readbyqxmd.com/read/27920819/co-administration-of-metformin-and-n-acetylcysteine-with-dietary-control-improves-the-biochemical-and-histological-manifestations-in-rats-with-non-alcoholic-fatty-liver
#1
Naglaa Mohamed El-Lakkany, Sayed Hassan Seif El-Din, Abdel-Nasser Abdel-Aal Sabra, Olfat Ali Hammam, Fatma Abdel-Latif Ebeid
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. This study was conceived in a NAFLD rat model to evaluate the efficacy of both metformin (MTF) and N-acetylcysteine (NAC) with dietary control on biochemical and histologic liver manifestations. Rats were classified into nine groups; normal (I), NAFLD-induced by feeding high-fat diet (HFD; II) for 12 weeks, NAFLD switched to regular diet (RD; III), NAFLD-HFD or -RD treated with MTF in a dose of 150 mg/kg (IV, V), NAC in a dose of 500 mg/kg (VI, VII) or MTF+NAC (VIII, IX) respectively for 8 weeks...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27888520/identifying-the-epileptogenic-zone-in-interictal-resting-state-meg-source-space-networks
#2
Ida A Nissen, Cornelis J Stam, Jaap C Reijneveld, Ilse E C W van Straaten, Eef J Hendriks, Johannes C Baayen, Philip C De Witt Hamer, Sander Idema, Arjan Hillebrand
OBJECTIVE: In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform activity. Our aim was to identify the epileptogenic zone on the basis of hub status of local brain areas in interictal magnetoencephalography (MEG) networks. METHODS: Preoperative eyes-closed resting-state MEG recordings were retrospectively analyzed in 22 patients with refractory epilepsy, of whom 14 were seizure-free 1 year after surgery...
November 26, 2016: Epilepsia
https://www.readbyqxmd.com/read/27886016/an-internet-of-things-platform-architecture-for-supporting-ambient-assisted-living-environments
#3
Charalampos Tsirmpas, Ioannis Kouris, Athanasios Anastasiou, Kostas Giokas, Dimitra Iliopoulou, Dimitris Koutsouris
Internet of Things (IoT) is the logical further development of today's Internet, enabling a huge amount of devices to communicate, compute, sense and act. IoT sensors placed in Ambient Assisted Living (AAL) environments, enable the context awareness and allow the support of the elderly in their daily routines, ultimately allowing an independent and safe lifestyle. The vast amount of data that are generated and exchanged between the IoT nodes require innovative context modeling approaches that go beyond currently used models...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27883257/determining-the-binding-affinities-of-prostate-specific-antigen-to-lectins-spr-and-microarray-approaches
#4
Pavel Damborský, Martina Zámorová, Jaroslav Katrlík
Prostate cancer (PCa) is one of the most common newly diagnosed cancer among men and we focused on its traditional biomarker, prostate-specific antigen (PSA), using targeted glycomics-based strategies. The aberrant glycosylation pattern of PSA may serve as valuable tool for improving PCa diagnosis including its early-stage. In the present work we evaluated the usability of two techniques, surface plasmon resonance and protein microarray assay, for the study and characterization of interactions of PSA (both free and complexed) with 6 lectins (SNA, ConA, RCA, AAL, WGA and MAA II)...
November 24, 2016: Proteomics
https://www.readbyqxmd.com/read/27879293/living-with-the-animals-animal-or-robotic-companions-for-the-elderly-in-smart-homes
#5
Dirk Preuß, Friederike Legal
Although the use of pet robots in senior living facilities and day-care centres, particularly for individuals suffering from dementia, has been intensively researched, the question of introducing pet robots into domestic settings has been relatively neglected. Ambient assisted living (AAL) offers many interface opportunities for integrating motorised companions. There are diverse medical reasons, as well as arguments from animal ethics, that support the use of pet robots in contrast to living with live animals...
November 22, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27878569/assay-of-hemoglobin-a1c-using-lectin-from-aleuria-aurantia
#6
Masato Kabata, Erina Hase, Kouta Kimura, Yuka Kobayashi, Yasushi Ueno, Kazuaki Yoshimune
Hemoglobin A1c (HbA1c) has an N-terminal fructosyl valine on the β-chain, and this modification is caused by the non-enzymatic glycosylation of hemoglobin (Hb). The relative concentration ratio of HbA1c to total Hb is an important biomarker for the diagnosis of diabetes. HbA1c-binding lectins were screened from 29 sources of lectin, and the lectin from Aleuria aurantia (AAL) was revealed to have higher affinity to HbA1c than to Hb. The concentration of HbA1c was determined by lectin-based enzyme-linked immunosorbent assay (ELISA) using the AAL lectin...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27869682/an-indoor-monitoring-system-for-ambient-assisted-living-based-on-internet-of-things-architecture
#7
Gonçalo Marques, Rui Pitarma
The study of systems and architectures for ambient assisted living (AAL) is undoubtedly a topic of great relevance given the aging of the world population. The AAL technologies are designed to meet the needs of the aging population in order to maintain their independence as long as possible. As people typically spend more than 90% of their time in indoor environments, indoor air quality (iAQ) is perceived as an imperative variable to be controlled for the inhabitants' wellbeing and comfort. Advances in networking, sensors, and embedded devices have made it possible to monitor and provide assistance to people in their homes...
November 17, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27866279/high-risk-carotid-plaques-identified-by-ct-angiogram-can-predict-acute-myocardial-infarction
#8
Wassim Mosleh, Keenan Adib, Punnanithinont Natdanai, Andres Carmona-Rubio, Roshan Karki, Jacienta Paily, Mohamed Abdel-Aal Ahmed, Sujit Vakkalanka, Narasa Madam, Gregory D Gudleski, Charles Chung, Umesh C Sharma
Prior studies identified the incremental value of non-invasive imaging by CT-angiogram (CTA) to detect high-risk coronary atherosclerotic plaques. Due to their superficial locations, larger calibers and motion-free imaging, the carotid arteries provide the best anatomic access for the non-invasive characterization of atherosclerotic plaques. We aim to assess the ability of predicting obstructive coronary artery disease (CAD) or acute myocardial infarction (MI) based on high-risk carotid plaque features identified by CTA...
November 19, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27858227/plug-play-brain-computer-interfaces-for-effective-active-and-assisted-living-control
#9
Niccolò Mora, Ilaria De Munari, Paolo Ciampolini, José Del R Millán
Brain-Computer Interfaces (BCI) rely on the interpretation of brain activity to provide people with disabilities with an alternative/augmentative interaction path. In light of this, BCI could be considered as enabling technology in many fields, including Active and Assisted Living (AAL) systems control. Interaction barriers could be removed indeed, enabling user with severe motor impairments to gain control over a wide range of AAL features. In this paper, a cost-effective BCI solution, targeted (but not limited) to AAL system control is presented...
November 17, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27856403/does-the-type-and-size-of-amplatzer-vascular-plug-affect-the-occlusion-time-of-pulmonary-arteriovenous-malformations
#10
Ahmed Kamel Abdel-Aal, Moustafa Omar Massoud, Dina Mahmoud Elantably
PURPOSE: Occlusion time (OT) is an important factor in the treatment of pulmonary arteriovenous malformations (PAVMs) since it can lead to serious complications. The purpose of our study is to calculate the OT of Amplatzer vascular plug (AVP, St Jude Medical), and correlate it to the type of the device used (AVP or AVP 2) and the percent of device oversizing. Technical success rates and complications were also recorded. METHODS: We retrospectively studied a total of 19 patients with 47 PAVMs who received percutaneous transcatheter embolization therapy using either AVP or AVP 2...
November 18, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27818346/improved-cancer-specificity-in-psa-assay-using-aleuria-aurantia-lectin-coated-eu-nanoparticles-for-detection
#11
Henna Kekki, Mari Peltola, Sandra van Vliet, Chris Bangma, Yvette van Kooyk, Kim Pettersson
OBJECTIVES: The objective was to study the differences in PSA fucosylation obtained from LNCaP and PC-3 prostate cancer cell lines, seminal plasma PSA and recombinant precursor form of PSA expressed in baculovirus, using Aleuria aurantia lectin (AAL). The aim was to assess whether differences in fucosylation (Fucα1-6/3GlcNAc carbohydrates) of PSA either in urine, blood or tissue enable the discrimination of patients with prostate cancer (PCa) from benign prostatic hyperplasia (BPH) and young males...
November 3, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27815774/the-topological-organization-of-white-matter-network-in-internet-gaming-disorder-individuals
#12
Jinquan Zhai, Lin Luo, Lijun Qiu, Yongqiang Kang, Bo Liu, Dahua Yu, Xiaoqi Lu, Kai Yuan
White matter (WM) integrity abnormalities had been reported in Internet gaming disorder (IGD). Diffusion tensor imaging (DTI) tractography allows identification of WM tracts, potentially providing information about the integrity and organization of relevant underlying WM fiber tracts' architectures, which has been used to investigate the connectivity of cortical and subcortical structures in several brain disorders. Unfortunately, relatively little is known about the thoroughly circuit-level characterization of topological property changes of WM network with IGD...
November 4, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27815382/therapeutic-treatment-with-sphingosine-1-phosphate-receptor-1-ligands-reduces-pertussis-inflammatory-pathology-by-a-pertussis-toxin-insensitive-mechanism
#13
Ciaran Skerry, Karen Scanlon, Jeremy Ardanuy, Drew Roberts, Li Zhang, Hugh Rosen, Nicholas H Carbonetti
Recent data have demonstrated the potential of sphingosine-1-phosphate receptor (S1PR) agonism in the treatment of infectious diseases. Previously we used a murine model of Bordetella pertussis infection to demonstrate that treatment with the S1PR agonist AAL-R reduces pulmonary inflammation during infection. Here we show that this effect is mediated via the S1PR1 receptor on LysM+ (myeloid) cells. Signaling via this receptor results in reduced lung inflammation and cellular recruitment as well as reduced morbidity and mortality in a neonatal mouse model of disease...
November 3, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27799919/feasibility-of-magnetoencephalography-after-endovascular-treatment-of-ruptured-intracranial-aneurysms
#14
Leodante da Costa, Benjamin T Dunkley, Allison Bethune, Amanda Robertson, Matt MacDonald, Elizabeth Pang
OBJECTIVE: Among good outcome survivors of aneurysmal subarachnoid hemorrhage (aSAH), only 23% have normal neurocognitive performance, despite imaging that is often normal. The aim of this work is to explore the use of magnetoencephalography (MEG) after endovascular treatment of ruptured aneurysms. METHODS: Good outcome aSAH patients treated with coiling and matched controls were recruited. Clinical assessments and resting-state MEG and anatomical MRI images were obtained...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27777556/attention-performance-measured-by-attention-network-test-is-correlated-with-global-and-regional-efficiency-of-structural-brain-networks
#15
Min Xiao, Haitao Ge, Budhachandra S Khundrakpam, Junhai Xu, Gleb Bezgin, Yuan Leng, Lu Zhao, Yuchun Tang, Xinting Ge, Seun Jeon, Wenjian Xu, Alan C Evans, Shuwei Liu
Functional neuroimaging studies have indicated the involvement of separate brain areas in three distinct attention systems: alerting, orienting, and executive control (EC). However, the structural correlates underlying attention remains unexplored. Here, we utilized graph theory to examine the neuroanatomical substrates of the three attention systems measured by attention network test (ANT) in 65 healthy subjects. White matter connectivity, assessed with diffusion tensor imaging deterministic tractography was modeled as a structural network comprising 90 nodes defined by the automated anatomical labeling (AAL) template...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27773385/altered-fucosyltransferase-expression-in-the-superior-temporal-gyrus-of-elderly-patients-with-schizophrenia
#16
Toni M Mueller, Stefani D Yates, Vahram Haroutunian, James H Meador-Woodruff
Glycosylation is a post-translational modification that is an essential element in cell signaling and neurodevelopmental pathway regulation. Glycan attachment can influence the tertiary structure and molecular interactions of glycosylated substrates, adding an additional layer of regulatory complexity to functional mechanisms underlying central cell biological processes. One type of enzyme-mediated glycan attachment, fucosylation, can mediate glycoprotein and glycolipid cell surface expression, trafficking, secretion, and quality control to modulate a variety of inter- and intracellular signaling cascades...
October 20, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27769306/improved-application-technique-of-albumin-glutaraldehyde-glue-for-repair-of-superficial-lung-defects
#17
Maximilian Bures, Patrick Zardo, Florian Länger, Ruoyu Zhang
BACKGROUND: Albumin-glutaraldehyde glue has gained widespread acceptance for treatment of alveolar air leaks (AAL) in thoracic surgery. As liquid run-off during application is detrimental to its sealing efficacy, we developed a modified technique and assessed it in vitro. METHODS: Caudal lobes of freshly excised swine lungs (n = 20) were intubated and ventilated. A standardized focal superficial parenchymal defect (40 × 25 mm) was created on the inflated lung...
October 21, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27761198/percutaneous-transhepatic-embolization-of-bleeding-rectal-varices-using-a-new-embolic-and-sclerotic-mixture-augmented-by-amplatzer-vascular-plug-2
#18
Ahmed Kamel Abdel-Aal, Nabila Dawoud, Amr Soliman Moustafa, Maysoon F Hamed, Souheil Saddekni
We report a case of 59-year-old female with non-alcoholic-steato-hepatitis (NASH) induced cirrhosis, who presented with hematochezia. The patient had a history of bleeding esophageal varices treated with endoscopic variceal ligation (EVL). Colonoscopy showed large rectal varices which were the source of her lower gastrointestinal bleeding (LGIB). Since endoscopic treatment for LGIB are limited, and because the patient had portal vein thrombosis which contraindicated transjugular intrahepatic portosystemic shunt (TIPS), we performed percutaneous transhepatic embolization of her rectal varices using a new mixture of embolic and sclerotic agents, followed by Amplatzer plug 2 (AVP 2)...
September 2016: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/27755965/rapid-diagnosis-of-hepatocellular-carcinoma-using-a-haptoglobin-elisa-assay-based-on-aal-coated-magnetic-beads
#19
Shuxin Shang, Lu Sun, Wei Li, Xue Qin, Shu Zhang, Yinkun Liu
Fucosylated glycans play a critical role in cell biology processes during the occurrence and development of tumor, such as cell signal transduction, cellular differentiation, ligand-receptor interactions, and metastasis formation. Fucosylated haptoglobin (Hp) was reported to be increased in hepatocellular carcinoma (HCC). In this study, we aimed to develop a convenient and sensitive AAL@Magbeads-based Hp ELISA assay to rapidly detect fucosylated Hp in 270 serum samples from HCC patients and normal controls...
September 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27701499/frequency-of-the-mesiopalatal-canal-in-upper-first-permanent-molars-viewed-through-computed-tomography
#20
Carlos Am Falcão, Verbena C Albuquerque, Neusinárya Ls Amorim, Sérgio Ap Freitas, Tanit C Santos, Francisca Tc Matos, Maria Aal Ferraz
The success of any endodontic therapy depends on factors such as correct diagnosis and prognosis. Unawareness or failure to locate additional canals, such as the mesiopalatal canal in the upper first molar, may lead to unsuccessful treatment. Hence, it is valid to consider all the resources available for locating this anatomic structure, e.g. the Cone-Beam Computed Tomography (CBCT). The purpose of this study was to verify the frequency of mesiopalatal canals in upper first permanent molars through computed tomography...
April 2016: Acta Odontológica Latinoamericana: AOL
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