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https://www.readbyqxmd.com/read/29791230/assessing-anxiety-and-depression-in-cancer-patients
#1
Fiona Milligan, Fe Martinez, SohSoha Hassan Mohd Abdel Aal, Samah Abdelrehim Ahmed, Beverly Joby, Jean Sultan Matalam, Sujala Sukumaran Nair, Anthony De Leon Maxion, Safia Sayed, Soji Samson Melepeedikayil
BACKGROUND: empirical evidence suggests that anxiety and depression in cancer patients is underdiagnosed and subsequently this patient population receives little or no support or intervention to address their psychosocial needs. It is often difficult to distinguish between normal emotional distress experienced following a cancer diagnosis and anxiety and depression, which can have a significant impact on coping mechanisms and subsequent outcomes. AIM: a qualitative study using the Hospital Anxiety and Depression Scale (HADS) was undertaken in the National Centre for Cancer Care and Research in Qatar...
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29761952/-automatic-classification-of-first-episode-drug-naive-schizophrenia-with-multi-modal-magnetic-resonance-imaging
#2
Yongzhe Yang, Yue Zhang, Fengchun Wu, Xiaobing Lu, Yuping Ning, Biao Huang, Xin Du, Chengwei Li, Kaixi Wang, Xiaoming Wu, Kai Wu
A great number of studies have demonstrated the structural and functional abnormalities in chronic schizophrenia (SZ) patients. However, few studies analyzed the differences between first-episode, drug-naive SZ (FESZ) patients and normal controls (NCs). In this study, we recruited 44 FESZ patients and 56 NCs, and acquired their multi-modal magnetic resonance imaging (MRI) data, including structural and resting-state functional MRI data. We calculated gray matter volume (GMV), regional homogeneity (ReHo), amplitude of low frequency fluctuation (ALFF), and degree centrality (DC) of 90 brain regions, basing on an automated anatomical labeling (AAL) atlas...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29736781/combination-of-rs-fmri-and-smri-data-to-discriminate-autism-spectrum-disorders-in-young-children-using-deep-belief-network
#3
Maryam Akhavan Aghdam, Arash Sharifi, Mir Mohsen Pedram
In recent years, the use of advanced magnetic resonance (MR) imaging methods such as functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) has recorded a great increase in neuropsychiatric disorders. Deep learning is a branch of machine learning that is increasingly being used for applications of medical image analysis such as computer-aided diagnosis. In a bid to classify and represent learning tasks, this study utilized one of the most powerful deep learning algorithms (deep belief network (DBN)) for the combination of data from Autism Brain Imaging Data Exchange I and II (ABIDE I and ABIDE II) datasets...
May 7, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29735682/laboratory-evolution-of-virus-like-nucleocapsids-from-nonviral-protein-cages
#4
Naohiro Terasaka, Yusuke Azuma, Donald Hilvert
Viruses are remarkable nanomachines that efficiently hijack cellular functions to replicate and self-assemble their components within a complex biological environment. As all steps of the viral life cycle depend on formation of a protective proteinaceous shell that packages the DNA or RNA genome, bottom-up construction of virus-like nucleocapsids from nonviral materials could provide valuable insights into virion assembly and evolution. Such constructs could also serve as safe alternatives to natural viruses for diverse nano- and biotechnological applications...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29733234/glycosylation-of-random-igg-distinguishes-seropositive-and-seronegative-rheumatoid-arthritis
#5
I Magorivska, B Döncző, T Dumych, A Karmash, M Boichuk, K Hychka, M Mihalj, M Szabó, E Csánky, J Rech, A Guttman, S G Vari, R Bilyy
The N-glycosylation of human immunoglobulins, especially IgGs, plays a critical role in determining affinity of IgGs towards their effector (pro- and anti-inflammatory) receptors. However, it is still not clear whether altered glycosylation is involved in only antibody-dependent disorders like seropositive rheumatoid arthritis (RA) or also in pathologies with similar clinical manifestations, but no specific autoantibodies like seronegative RA. The clarification of that uncertainty was the aim of the current study...
May 7, 2018: Autoimmunity
https://www.readbyqxmd.com/read/29729253/identifying-amci-with-functional-connectivity-network-characteristics-based-on-subtle-aal-atlas
#6
Zhizheng Zhuo, Xiao Mo, Xiangyu Ma, Ying Han, Haiyun Li
PURPOSE: To investigate the subtle functional connectivity alterations of aMCI based on AAL atlas with 1024 regions (AAL_1024 atlas). MATERIALS AND METHODS: Functional MRI images of 32 aMCI patients (Male/Female:15/17, Ages:66.8±8.36y) and 35 normal controls (Male/Female:13/22, Ages: 62.4±8.14y) were obtained in this study. Firstly, functional connectivity networks were constructed by Pearson's Correlation based on the subtle AAL_1024 atlas. Then, local and global network parameters were calculated from the thresholding functional connectivity matrices...
May 2, 2018: Brain Research
https://www.readbyqxmd.com/read/29726432/towards-an-imu-evaluation-framework-for-human-body-tracking
#7
Verena Venek, Wolfgang Kremser, Cornelia Schneider
Existing full-body tracking systems, which use Inertial Measurement Units (IMUs) as sensing unit, require expert knowledge for setup and data collection. Thus, the daily application for human body tracking is difficult. In particular, in the field of active and assisted living (AAL), tracking human movements would enable novel insights not only into the quantity but also into the quality of human movement, for example by monitoring functional training. While the current market offers a wide range of products with vastly different properties, literature lacks guidelines for choosing IMUs for body tracking applications...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29713176/aberrant-brain-functional-connectome-in-patients-with-obstructive-sleep-apnea
#8
Li-Ting Chen, Xiao-Le Fan, Hai-Jun Li, Cheng-Long Ye, Hong-Hui Yu, Hui-Zhen Xin, Hong-Han Gong, De-Chang Peng, Li-Ping Yan
Objective: Obstructive sleep apnea (OSA) is accompanied by widespread abnormal spontaneous regional activity related to cognitive deficits. However, little is known about the topological properties of the functional brain connectome of patients with OSA. This study aimed to use the graph theory approaches to investigate the topological properties and functional connectivity (FC) of the functional connectome in patients with OSA, based on resting-state functional magnetic resonance imaging (rs-fMRI)...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29695737/multi-lectin-affinity-chromatography-and-quantitative-proteomic-analysis-reveal-differential-glycoform-levels-between-prostate-cancer-and-benign-prostatic-hyperplasia-sera
#9
Sarah M Totten, Ravali Adusumilli, Majlinda Kullolli, Cheylene Tanimoto, James D Brooks, Parag Mallick, Sharon J Pitteri
Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need to distinguish these cases at the molecular level. Protein glycosylation plays an important role in a number of cellular processes involved in neoplastic progression and is aberrant in PCa. In this study, we systematically interrogate the alterations in the circulating levels of hundreds of serum proteins and their glycoforms in PCa and BPH samples using multi-lectin affinity chromatography and quantitative mass spectrometry-based proteomics...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29690534/a-system-based-on-the-internet-of-things-for-real-time-particle-monitoring-in-buildings
#10
Gonçalo Marques, Cristina Roque Ferreira, Rui Pitarma
Occupational health can be strongly influenced by the indoor environment as people spend 90% of their time indoors. Although indoor air quality (IAQ) is not typically monitored, IAQ parameters could be in many instances very different from those defined as healthy values. Particulate matter (PM), a complex mixture of solid and liquid particles of organic and inorganic substances suspended in the air, is considered the pollutant that affects more people. The most health-damaging particles are the ≤PM10 (diameter of 10 microns or less), which can penetrate and lodge deep inside the lungs, contributing to the risk of developing cardiovascular and respiratory diseases, as well as of lung cancer...
April 21, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29667208/the-use-of-cardiac-ct-alone-to-exclude-left-atrial-thrombus-before-atrial-fibrillation-ablation-efficiency-safety-and-cost-analysis
#11
Wassim Mosleh, Ali Sheikh, Zaid Said, Mohamed A Abdel-Aal, Siri Gadde, Tanvi Shah, Michael F Wilson, Hiroko Beck, Chee Kim, Umesh C Sharma
BACKGROUND: Atrial fibrillation (AF) is a growing financial burden on the healthcare system. Cardiac computed tomographic angiography (CCTA) is needed for pulmonary vein mapping before AF ablation (AFA). CCTA has shown to be an alternative to transesophageal echocardiogram (TEE) to rule-out left atrial appendage thrombus (LAAT) pre-AFA. We aim to examine the safety, cost-effectiveness, and time-efficiency of utilizing CCTA alone to rule out LAAT before AFA. METHODS: We prospectively screened patients with paroxysmal AF undergoing cryoablation...
April 17, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29663501/the-effect-of-plant-lectins-on-the-survival-and-malignant-behaviors-of-thyroid-cancer-cells
#12
Engin Kaptan, Serap Sancar-Bas, Aylin Sancakli, Suna Bektas, Sehnaz Bolkent
Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up-regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29608970/characterization-of-vibrio-cholerae-neuraminidase-as-an-immunomodulator-for-novel-formulation-of-oral-allergy-immunotherapy
#13
Susanne C Diesner, Cornelia Bergmayr, Xue-Yan Wang, Denise Heiden, Sarah Exenberger, Franziska Roth-Walter, Philipp Starkl, Davide Ret, Isabella Pali-Schöll, Franz Gabor, Eva Untersmayr
To improve current mucosal allergen immunotherapy Vibrio cholerae neuraminidase (NA) was evaluated as a novel epithelial targeting molecule for functionalization of allergen-loaded, poly(D,L-lactide-co-glycolide) (PLGA) microparticles (MPs) and compared to the previously described epithelial targeting lectins wheat germ agglutinin (WGA) and Aleuria aurantia lectin (AAL). All targeters revealed binding to Caco-2 cells, but only NA had high binding specificity to α-L fucose and monosialoganglioside-1. An increased transepithelial uptake was found for NA-MPs in a M-cell co-culture model...
March 30, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29594423/epidemiological-observations-on-cryptosporidiosis-and-molecular-characterization-of-cryptosporidium-spp-in-sheep-and-goats-in-kuwait
#14
Qais A H Majeed, Osama M E El-Azazy, Nadra-Elwgoud M I Abdou, Zein A Al-Aal, Amira I El-Kabbany, Laila M A Tahrani, Maha S AlAzemi, Yuanfei Wang, Yaoyu Feng, Lihua Xiao
Molecular epidemiological analysis of cryptosporidiosis in Middle Eastern countries suggests that small ruminants could play a major role in the transmission of Cryptosporidium spp. to humans, with a dominance of Cryptosporidium parvum, especially its IId subtypes. However, little information is available on the epidemiology and risk factors of cryptosporidiosis as well the distribution of Cryptosporidium species/genotypes and subtypes in small ruminants in this area, including Kuwait. In the present study, 47 farms from several areas in Kuwait were visited once during October 2014 to September 2015 to collect data on risk factors associated with Cryptosporidium infection...
March 29, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29571976/the-effect-of-vitamin-c-and-or-e-supplementations-on-type-2-diabetic-adult-males-under-metformin-treatment-a-single-blinded-randomized-controlled-clinical-trial
#15
Ali Abd El-Aal, Eman A Abd El-Ghffar, Asmaa Abu Ghali, Mohammed R Zughbur, Mahmoud M Sirdah
BACKGROUND AND AIM: Recently, there has been an increasing interest in the influence of antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients (T2DM). This single-blinded randomized controlled clinical trial aimed to investigate the effect of vitamin C and/or E supplementation on the efficacy of oral hypoglycemic therapy in T2DM Palestinian male patients from the Gaza Strip. METHODS: Forty T2DM male patients aged 40-60 years on metformin treatment were randomly divided into four groups, each group received an additional one of the following daily oral supplements for 90 days: placebo; vitamin C; vitamin E and vitamin C plus vitamin E...
March 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29563564/broadband-acoustic-subwavelength-imaging-by-rapidly-modulated-stratified-media
#16
Xing-Feng Zhu, Qi Wei, Da-Jian Wu, Xiao-Jun Liu
An acoustic anisotropic lens (AAL) based on large mass-density modulation depth (LMMD) medium is proposed for subwavelength imaging. The underlying mechanism for converting evanescent components into propagating waves is attributed to the strong suppression of the transverse velocity field component in LMMD medium. In addition, the proposed lens can operate in a broadband manner, which is more flexible in practical applications. Both transfer matrix method and finite element method are used to corroborate the subwavelength imaging capabilities of the proposed lens...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29552257/approaches-for-safe-transarterial-chemoembolization-of-multifocal-hepatocellular-carcinoma-with-retrograde-flow-in-a-retroportal-artery
#17
Souheil Saddekni, Amr Soliman Moustafa, Sherif Moawad, Khalid Mahmoud, Basant Farouk Hamed, Ahmed Kamel Abdel-Aal
We report a case of an 81-year-old woman with multifocal hepatocellular carcinoma who underwent transarterial chemoembolization. The patient had significant superior mesenteric artery (SMA) ostial stenosis, which led to retrograde flow in the retroportal artery to the SMA. The authors adopted several approaches to avoid potential nontarget embolization that might result from the change in the hemodynamics in the hepatoenteric arteries by initially stenting the SMA ostial stenosis as well as the use of the Surefire infusion system and balloon occlusion for delivery of chemoembolization material to tumors in the hepatic lobes...
February 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29548433/compositional-and-antioxidant-properties-of-anthocyanin-rich-products-prepared-from-purple-wheat
#18
El-Sayed M Abdel-Aal, Pierre Hucl, Iwona Rabalski
Demands for anthocyanin-rich ingredients are steadily growing due to their positive functions in human health and food coloration. Commercially available purple wheat was evaluated as a source of functional ingredients based on anthocyanin composition and antioxidant properties. Anthocyanins were concentrated in the bran fraction by about 2-fold and then the bran was further processed into anthocyanin-rich powder using ethanol extraction and column purification. Batch studies showed that anthocyanin concentration factor increased by about 81- to 135-fold in the powder depending on batch size...
July 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29522112/toward-leveraging-human-connectomic-data-in-large-consortia-generalizability-of-fmri-based-brain-graphs-across-sites-sessions-and-paradigms
#19
Hengyi Cao, Sarah C McEwen, Jennifer K Forsyth, Dylan G Gee, Carrie E Bearden, Jean Addington, Bradley Goodyear, Kristin S Cadenhead, Heline Mirzakhanian, Barbara A Cornblatt, Ricardo E Carrión, Daniel H Mathalon, Thomas H McGlashan, Diana O Perkins, Aysenil Belger, Larry J Seidman, Heidi Thermenos, Ming T Tsuang, Theo G M van Erp, Elaine F Walker, Stephan Hamann, Alan Anticevic, Scott W Woods, Tyrone D Cannon
While graph theoretical modeling has dramatically advanced our understanding of complex brain systems, the feasibility of aggregating connectomic data in large imaging consortia remains unclear. Here, using a battery of cognitive, emotional and resting fMRI paradigms, we investigated the generalizability of functional connectomic measures across sites and sessions. Our results revealed overall fair to excellent reliability for a majority of measures during both rest and tasks, in particular for those quantifying connectivity strength, network segregation and network integration...
March 7, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29520641/structural-connectome-with-high-angular-resolution-diffusion-imaging-mri-assessing-the-impact-of-diffusion-weighting-and-sampling-on-graph-theoretic-measures
#20
Giuseppina Caiazzo, Michele Fratello, Federica Di Nardo, Francesca Trojsi, Gioacchino Tedeschi, Fabrizio Esposito
PURPOSE: Advances in computational network analysis have enabled the characterization of topological properties of human brain networks (connectomics) from high angular resolution diffusion imaging (HARDI) MRI structural measurements. In this study, the effect of changing the diffusion weighting (b value) and sampling (number of gradient directions) was investigated in ten healthy volunteers, with specific focus on graph theoretical network metrics used to characterize the human connectome...
May 2018: Neuroradiology
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