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https://www.readbyqxmd.com/read/28229261/revision-of-neolebouria-gibson-1976-digenea-opecoelidae-with-trilobovarium-n-g-for-species-infecting-tropical-and-subtropical-shallow-water-fishes
#1
Storm B Martin, Scott C Cutmore, Thomas H Cribb
A new opecoelid trematode is reported from fishes of the Lethrinidae, Lutjanidae and Nemipteridae off Lizard Island on the northern Great Barrier Reef, Australia. The new species keys to Neolebouria Gibson, 1976 and shows strong similarity to several species of that genus, but is not consistent with the type-species, N. georgiensis Gibson, 1976, or others known from temperate/polar and/or deep-sea fishes. The new species is also phylogenetically distant from N. lanceolata (Price, 1934) Reimer, 1987, the only representative of the genus for which molecular data are available...
February 22, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28227863/age-estimation-using-effective-brain-local-features-from-t1-weighted-images
#2
Ryuichi Fujimoto, Chihiro Kondo, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki, Ryuichi Fujimoto, Chihiro Kondo, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki, Koichi Ito, Yasuyuki Taki, Takafumi Aoki, Chihiro Kondo, Kazunori Sato, Hiroshi Fukuda, Ryuichi Fujimoto, Kai Wu
This paper proposes a simple method of selecting effective brain local features for age estimation from T1-weighted MR images. We also employ the high-resolution AAL atlas, which is defined by 1,024 local regions, to improve the accuracy of age estimation. We evaluate performance of the proposed method using 1,099 T1-weighted images from a large-scale brain MR image database of healthy Japanese, and demonstrate that the proposed method exhibits efficient performance of age estimation compared with conventional methods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28187320/mechanical-and-biological-behavior-of-ultrafine-grained-ti-alloy-aneurysm-clip-processed-using-high-pressure-torsion
#3
Ho Yong Um, Byung Ho Park, Dong-Hyun Ahn, Mohamed Ibrahim Abd El Aal, Jaechan Park, Hyoung Seop Kim
Severe plastic deformation (SPD) has recently been advanced as the main process for fabricating bulk ultrafine grained or nanocrystalline metallic materials, which present much higher strength and better bio-compatibility than coarse-grained counterparts. Medical devices, such as aneurysm clips and dental implants, require high mechanical and biological performance (e.g., stiffness, yield strength, fatigue resistance, and bio-compatibility). These requirements match well the characteristics of SPD-processed materials...
February 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28159012/identification-of-micrornas-expressed-in-the-midgut-of-aedes-albopictus-during-dengue-infection
#4
Jianxin Su, Chunxiao Li, Yingmei Zhang, Ting Yan, Xiaojuan Zhu, Minghui Zhao, Dan Xing, Yande Dong, Xiaoxia Guo, Tongyan Zhao
BACKGROUND: The midgut is the first barrier to dengue virus (DENV) infections of mosquitoes and therefore is a major bottleneck for the subsequent development of vector competence. However, the molecular mechanisms responsible for this barrier are unknown. RESULTS: We constructed three small RNA libraries from the midguts of adult Aedes albopictus females that had been fed on either sugar solution, an uninfected blood meal, or a blood meal infected with DENV-2, and112 conserved microRNAs represented by 173 miRNA sequences were identified, with 34 novel microRNAs predicted by Mireap, RNAfold and Sfold software...
February 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28154795/connectomic-profile-and-clinical-phenotype-in-newly-diagnosed-glioma-patients
#5
Jolanda Derks, Anne R Dirkson, Philip C de Witt Hamer, Quinten van Geest, Hanneke E Hulst, Frederik Barkhof, Petra J W Pouwels, Jeroen J G Geurts, Jaap C Reijneveld, Linda Douw
Gliomas are primary brain tumors, originating from the glial cells in the brain. In contrast to the more traditional view of glioma as a localized disease, it is becoming clear that global brain functioning is impacted, even with respect to functional communication between brain regions remote from the tumor itself. However, a thorough investigation of glioma-related functional connectomic profiles is lacking. Therefore, we constructed functional brain networks using functional MR scans of 71 glioma patients and 19 matched healthy controls using the automated anatomical labelling (AAL) atlas and interregional Pearson correlation coefficients...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28131026/preparation-and-characterization-of-ph-responsive-polyacrylamide-molecularly-imprinted-polymer-application-to-isolation-of-recombinant-and-wild-type-human-serum-albumin-from-biological-sources
#6
May A Abd El-Aal, Medhat A Al-Ghobashy, Faten Abdel Aziz Fathalla, Yasser S El-Saharty
In this work pH-responsive neutral and cationic polyacrylamide molecularly imprinted polymers (nMIP and cMIP, respectively) were prepared for separation of recombinant and wild type human serum albumin (HSA, pI 4.7) using mixture of polymerization initiators. The effect of pH during preparation and adsorption stages at pI(HSA)±2.0 on binding capacity and selectivity; imprinting factor (IF) was thoroughly investigated. SE-HPLC and RP-HPLC were employed for thorough evaluation of the stability of HSA at the studied experimental conditions and for simultaneous determination of HSA and erythropoietin (EPO) in their mixtures, respectively...
January 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28125912/olfactory-network-differences-in-master-sommeliers-connectivity-analysis-using-granger-causality-and-graph-theoretical-approach
#7
Karthik R Sreenivasan, Xiaowei Zhuang, Sarah Banks, Virendra Mishra, Zhengshi Yang, Gopikrishna Deshpande, Dietmar Cordes
Previous studies investigating the differences in olfactory processing and judgments between trained sommeliers and controls have shown increased activations in brain regions involving higher-level cognitive processes in sommeliers. However, there is little information about the influence of expertise on causal connectivity and topological properties of the connectivity networks between these regions. Therefore, the current study focuses on addressing these questions in a functional magnetic resonance imaging (fMRI) study of olfactory perception in Master Sommeliers...
January 26, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28117314/benzotriazole-mediated-synthesis-and-antibacterial-activity-of-novel-n-acylcephalexins
#8
Khalid A Agha, Nader E Abo-Dya, Tarek S Ibrahim, Eatedal H Abdel-Aal, Wael A Hegazy
Cephalexin (1) was acylated using N-acylbenzotriazoles (3a-k') derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%-96%). Antibacterial screening of the novel cephalosporins revealed that all targets (4a-j) retained the antibacterial activity of cephalexin against Staphylococcus aureus (ATCC 6538). N-Nicotinylcephalexin (4c) and N-(3,4,5-trimethoxybenzoyl)cephalexin (4g) exhibited a broader spectrum of antibacterial activity towards standard strains of Staphylococcus aureus (ATCC 6538), Paenibacillus polymyxa (ATCC 842), and Escherichia coli (ATCC 10536) as well as a resistant strain of Pseudomonas aeruginosa (ATCC 27853)...
April 13, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28114031/classification-of-alzheimer-s-disease-using-whole-brain-hierarchical-network
#9
Jin Liu, Min Li, Wei Lan, Fang-Xiang Wu, Yi Pan, Jianxin Wang
Regions of interest (ROIs) based classification has been widely investigated for analysis of brain magnetic resonance imaging (MRI) images to assist the diagnosis of Alzheimer's disease (AD) including its early warning and developing stages, e.g., mild cognitive impairment (MCI) including MCI converted to AD (MCIc) and MCI not converted to AD (MCInc). Since an ROI representation of brain structures is obtained either by pre-definition or by adaptive parcellation, the corresponding ROI in different brains can be measured...
December 2, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28098103/relation-of-fibroblast-growth-factor-23-and-cardiovascular-calcification-in-end-stage-kidney-disease-patients-on-regular-hemodialysis
#10
Tarek Zakaria El Baz, Osama Ahmed Khamis, Osama Ashry Ahmed Gheith, Salama Saad Abd Ellateif, Abdallah Mahmoud Abdallah, Hussein Chahine Abd El Aal
More than half of deaths in end-stage kidney disease (ESKD) patients are due to cardiovascular disease. Elevated fibroblast growth factor 23 (FGF-23) was found to be associated with mortality in hemodialysis (HD) patients and correlates with peripheral calcification. Aortic calcification is associated with coronary artery calcification. Both aortic and peripheral vascular calcifications were associated with mortality in chronic kidney disease. We aimed to investigate the relation between intact FGF-23 and cardiovascular calcification in patients with ESKD who were maintained on regular HD...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28068596/evaluation-of-the-effectiveness-of-low-dose-aspirin-and-omega-3-in-treatment-of-asymmetrically-intrauterine-growth-restriction-a-randomized-clinical-trial
#11
Mohammed K Ali, Maggy E Amin, Ahmed F Amin, Diaa Eldeen M Abd El Aal
OBJECTIVE: To test the effect of aspirin and omega 3 on fetal weight as well as feto-maternal blood flow in asymmetrical intrauterine growth restriction (IUGR). STUDY DESIGN: This study is a clinically registered (NCT02696577), open, parallel, randomized controlled trial, conducted at Assiut Woman's Health Hospital, Egypt including 80 pregnant women (28-30 weeks) with IUGR. They were randomized either to group I: aspirin or group II: aspirin plus omega 3. The primary outcome was the fetal weight after 6 weeks of treatment...
January 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28040121/sublingual-misoprostol-versus-intravenous-oxytocin-in-reducing-bleeding-during-and-after-cesarean-delivery-a-randomized-clinical-trial
#12
Essam Rashad Othman, Margaret Fathy Fayez, Diaa Eldeen Mohamed Abd El Aal, Hazem Saad El-Dine Mohamed, Ahmed Mohammed Abbas, Mohammed Khairy Ali
OBJECTIVE: This study compares the efficacy of sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery. MATERIALS AND METHODS: A randomized clinical trial conducted on 120 pregnant women at term (37-40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either sublingual misoprostol 400 μg or intravenous infusion of 20 units of oxytocin after delivery of the neonate. The main outcome measures were blood loss at and 2 hours after cesarean delivery, change in hematocrit value, need for any additional oxytocic drugs, and drug-related side effects...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28029136/application-of-lectin-array-technology-for-biobetter-characterization-its-correlation-with-fc%C3%AE-riii-binding-and-adcc
#13
Markus Roucka, Klaus Zimmermann, Markus Fido, Andreas Nechansky
Lectin microarray technology was applied to compare the glycosylation pattern of the monoclonal antibody MB311 expressed in SP2.0 cells to an antibody-dependent cellular cytotoxic effector function (ADCC)-optimized variant (MB314). MB314 was generated by a plant expression system that uses genetically modified moss protoplasts (Physcomitrella patens) to generate a de-fucosylated version of MB311. In contrast to MB311, no or very low interactions of MB314 with lectins Aspergillus oryzae l-fucose (AOL), Pisum sativum agglutinin (PSA), Lens culinaris agglutinin (LCA), and Aleuria aurantia lectin (AAL) were observed...
December 24, 2016: Microarrays
https://www.readbyqxmd.com/read/27939085/a-seer-database-analysis-of-the-survival-advantage-of-transarterial-chemoembolization-for-hepatocellular-carcinoma-an-underutilized-therapy
#14
Stephen H Gray, Jared A White, Peng Li, Meredith L Kilgore, David T Redden, Ahmed K Abdel Aal, Heather N Simpson, Brendan McGuire, Devin E Eckhoff, Derek A Dubay
PURPOSE: To measure transarterial chemoembolization utilization and survival benefit among patients with hepatocellular carcinoma (HCC) in the Surveillance, Epidemiology, and End Results (SEER) patient population. MATERIALS AND METHODS: A retrospective study identified 37,832 patients with HCC diagnosed between 1991 and 2011. Survival was estimated by Kaplan-Meier method and compared by log-rank test. Propensity-score matching was used to address an imbalance of covariates...
February 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27929688/anatomical-location-differences-between-mutated-and-wild-type-isocitrate-dehydrogenase-1-in-low-grade-gliomas
#15
Jinhua Yu, Zhifeng Shi, Chunhong Ji, Yuxi Lian, Yuanyuan Wang, Liang Chen, Ying Mao
Anatomical location of gliomas has been considered as a factor implicating the contributions of a specific precursor cells during the tumor growth. Isocitrate dehydrogenase 1 (IDH1) is a pathognomonic biomarker with a significant impact on the development of gliomas and remarkable prognostic effect. The correlation between anatomical location of tumor and IDH1 states for low grade gliomas was analyzed quantitatively in this study. 92 patients diagnosed of low grade glioma pathologically were recruited in this study, including 65 patients with IDH1-mutated glioma and 27 patients with wide-type IDH1...
December 8, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27928777/clinical-and-mutational-characterizations-of-ten-indian-patients-with-beta-ketothiolase-deficiency
#16
Elsayed Abdelkreem, Radha Rama Devi Akella, Usha Dave, Sudhir Sane, Hiroki Otsuka, Hideo Sasai, Yuka Aoyama, Mina Nakama, Hidenori Ohnishi, Shaimaa Mahmoud, Mohamed Abd El Aal, Toshiyuki Fukao
Beta-ketothiolase deficiency (mitochondrial acetoacetyl-CoA thiolase (T2) deficiency) is an inherited disease of isoleucine catabolism and ketone body utilization caused by ACAT1 mutations. We identified ten Indian patients who manifested with ketoacidotic episodes of variable severity. The patients showed increased urinary excretion of isoleucine-catabolic intermediates: 2-methyl-3-hydroxybutyrate, 2-methylacetoacetate, and tiglylglycine. Six patients had a favorable outcome, one died, and three developed neurodevelopmental sequela...
December 8, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27925595/classification-of-alzheimer-s-disease-using-whole-brain-hierarchical-network
#17
Jin Liu, Min Li, Wei Lan, Fang-Xiang Wu, Yi Pan, Jianxin Wang
Regions of interest (ROIs) based classification has been widely investigated for analysis of brain magnetic resonance imaging (MRI) images to assist the diagnosis of Alzheimer's disease (AD) including its early warning and developing stages, e.g., mild cognitive impairment (MCI) including MCI converted to AD (MCIc) and MCI not converted to AD (MCInc). Since an ROI representation of brain structures is obtained either by pre-definition or by adaptive parcellation, the corresponding ROI in different brains can be measured...
December 2, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/27920819/co-administration-of-metformin-and-n-acetylcysteine-with-dietary-control-improves-the-biochemical-and-histological-manifestations-in-rats-with-non-alcoholic-fatty-liver
#18
Naglaa Mohamed El-Lakkany, Sayed Hassan Seif El-Din, Abdel-Nasser Abdel-Aal Sabra, Olfat Ali Hammam, Fatma Abdel-Latif Ebeid
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. This study was conceived in a NAFLD rat model to evaluate the efficacy of both metformin (MTF) and N-acetylcysteine (NAC) with dietary control on biochemical and histologic liver manifestations. Rats were classified into nine groups; normal (I), NAFLD-induced by feeding high-fat diet (HFD; II) for 12 weeks, NAFLD switched to regular diet (RD; III), NAFLD-HFD or -RD treated with MTF in a dose of 150 mg/kg (IV, V), NAC in a dose of 500 mg/kg (VI, VII) or MTF+NAC (VIII, IX) respectively for 8 weeks...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27888520/identifying-the-epileptogenic-zone-in-interictal-resting-state-meg-source-space-networks
#19
Ida A Nissen, Cornelis J Stam, Jaap C Reijneveld, Ilse E C W van Straaten, Eef J Hendriks, Johannes C Baayen, Philip C De Witt Hamer, Sander Idema, Arjan Hillebrand
OBJECTIVE: In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform activity. Our aim was to identify the epileptogenic zone on the basis of hub status of local brain areas in interictal magnetoencephalography (MEG) networks. METHODS: Preoperative eyes-closed resting-state MEG recordings were retrospectively analyzed in 22 patients with refractory epilepsy, of whom 14 were seizure-free 1 year after surgery...
January 2017: Epilepsia
https://www.readbyqxmd.com/read/27886016/an-internet-of-things-platform-architecture-for-supporting-ambient-assisted-living-environments
#20
Charalampos Tsirmpas, Ioannis Kouris, Athanasios Anastasiou, Kostas Giokas, Dimitra Iliopoulou, Dimitris Koutsouris
Internet of Things (IoT) is the logical further development of today's Internet, enabling a huge amount of devices to communicate, compute, sense and act. IoT sensors placed in Ambient Assisted Living (AAL) environments, enable the context awareness and allow the support of the elderly in their daily routines, ultimately allowing an independent and safe lifestyle. The vast amount of data that are generated and exchanged between the IoT nodes require innovative context modeling approaches that go beyond currently used models...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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