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https://www.readbyqxmd.com/read/28325476/erectile-dysfunction-in-patients-with-nonalcoholic-fatty-liver-disease
#1
Ahmad Farooq Alsayed Hasanain, Reem Ezzat Mahdy, Ali Mohamed Abdel-Rahman Mahran, Ahmed Serag Mahmoud Safwat, Asmaa Omar Mohamed, Sherif Mohamed Abdel-Aal
BACKGROUND AND STUDY AIMS: There is a lack of studies on erectile dysfunction (ED) in patients diagnosed with nonalcoholic fatty liver disease (NAFLD). The present study aimed to estimate the prevalence of ED in patients with NAFLD and to determine the independent predictors of ED in these patients. PATIENTS AND METHODS: We conducted a prospective, hospital-based study of 192 consecutive male patients with NAFLD. All patients underwent clinical evaluation; abdominal ultrasonography; test for viral hepatitis markers; and estimation of liver chemistry panel, complete blood count, prothrombin time, serum lipids panel, serum testosterone, and fasting serum levels of glucose, insulin, and C-peptide...
March 16, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28301993/outcome-of-living-donor-liver-transplant-for-hepatocellular-carcinoma-15-year-single-center-experience-in-egypt
#2
Refaat Kamel, Yaser Hatata, Karim Hosny, Ahmed Nabil, Alaa El-Deen Abd-Allah, Aaser Mostafa, Amr Abdel-Aal, Mahmoud Z Elganzoury, Osama Elmalt, Ibrahim Marwan, Adel Hosny
OBJECTIVES: Liver transplant performed for hepatocellular carcinoma must adhere to criteria for the size and number of focal hepatic lesions to lower the incidence of recurrence and achieve survival rates comparable to patients transplanted for other indications. Since the Milan criteria were established in 1996, there have been many less restrictive criteria yielding similar results. Our aim was to identify the prognostic factors for patient survival and for recurrence of hepatocellular carcinoma for patients within and beyond the Milan criteria...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28296934/reverse-lectin-elisa-for-detecting-fucosylated-forms-of-%C3%AE-1-acid-glycoprotein-associated-with-hepatocellular-carcinoma
#3
Eva Åström, Per Stål, Robin Zenlander, Pia Edenvik, Catharina Alexandersson, Mats Haglund, Ingvar Rydén, Peter Påhlsson
Altered fucosylation of glycoproteins is associated with development of hepatocellular carcinoma (HCC). Lectins have been commonly used to assay changes in fucosylation of plasma glycoproteins. In the present study a recombinantly engineered form of the fucose binding lectin Aleuria aurantia (AAL) consisting of a single binding site for fucose (S2), was used to construct a reverse lectin ELISA method. Microtiter plates coated with the S2 lectin were used to capture glycoproteins from plasma samples followed by antibody detection of S2-bound fucosylated α1-acid glycoprotein (S2-bound AGP)...
2017: PloS One
https://www.readbyqxmd.com/read/28287436/plasma-based-degradation-of-mycotoxins-produced-by-fusarium-aspergillus-and-alternaria-species
#4
Lars Ten Bosch, Katharina Pfohl, Georg Avramidis, Stephan Wieneke, Wolfgang Viöl, Petr Karlovsky
The efficacy of cold atmospheric pressure plasma (CAPP) with ambient air as working gas for the degradation of selected mycotoxins was studied. Deoxynivalenol, zearalenone, enniatins, fumonisin B1, and T2 toxin produced by Fusarium spp., sterigmatocystin produced by Aspergillus spp. and AAL toxin produced by Alternaria alternata were used. The kinetics of the decay of mycotoxins exposed to plasma discharge was monitored. All pure mycotoxins exposed to CAPP were degraded almost completely within 60 s. Degradation rates varied with mycotoxin structure: fumonisin B1 and structurally related AAL toxin were degraded most rapidly while sterigmatocystin exhibited the highest resistance to degradation...
March 10, 2017: Toxins
https://www.readbyqxmd.com/read/28270767/a-phosphorylatable-sphingosine-analog-induces-airway-smooth-muscle-cytostasis-and-reverses-airway-hyperresponsiveness-in-experimental-asthma
#5
David R Gendron, Pascale B Lecours, Anne-Marie Lemay, Marie-Josée Beaulieu, Carole-Ann Huppé, Audrey Lee-Gosselin, Nicolas Flamand, Anthony S Don, Élyse Bissonnette, Marie-Renée Blanchet, Mathieu Laplante, Sylvain G Bourgoin, Ynuk Bossé, David Marsolais
In asthma, excessive bronchial narrowing associated with thickening of the airway smooth muscle (ASM) causes respiratory distress. Numerous pharmacological agents prevent experimental airway hyperresponsiveness (AHR) when delivered prophylactically. However, most fail to resolve this feature after disease is instated. Although sphingosine analogs are primarily perceived as immune modulators with the ability to prevent experimental asthma, they also influence processes associated with tissue atrophy, supporting the hypothesis that they could interfere with mechanisms sustaining pre-established AHR...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28269605/age-estimation-using-effective-brain-local-features-from-t1-weighted-images
#6
Ryuichi Fujimoto, Chihiro Kondo, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki
This paper proposes a simple method of selecting effective brain local features for age estimation from T1-weighted MR images. We also employ the high-resolution AAL atlas, which is defined by 1,024 local regions, to improve the accuracy of age estimation. We evaluate performance of the proposed method using 1,099 T1-weighted images from a large-scale brain MR image database of healthy Japanese, and demonstrate that the proposed method exhibits efficient performance of age estimation compared with conventional methods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264847/antibiotic-allergy-labels-in-liver-transplant-recipients-alt-study
#7
S Khumra, J Chan, K Urbancic, T Worland, P Angus, B Jones, M L Grayson, J A Trubiano
Patient-reported antibiotic allergies (so-called antibiotic allergy labels [AALs]) are associated with suboptimal prescribing and inferior clinical outcomes, especially in the immunocompromised (1, 2).….
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28229261/revision-of-neolebouria-gibson-1976-digenea-opecoelidae-with-trilobovarium-n-g-for-species-infecting-tropical-and-subtropical-shallow-water-fishes
#8
Storm B Martin, Scott C Cutmore, Thomas H Cribb
A new opecoelid trematode is reported from fishes of the Lethrinidae, Lutjanidae and Nemipteridae off Lizard Island on the northern Great Barrier Reef, Australia. The new species keys to Neolebouria Gibson, 1976 and shows strong similarity to several species of that genus, but is not consistent with the type-species, N. georgiensis Gibson, 1976, or others known from temperate/polar and/or deep-sea fishes. The new species is also phylogenetically distant from N. lanceolata (Price, 1934) Reimer, 1987, the only representative of the genus for which molecular data are available...
March 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28227863/age-estimation-using-effective-brain-local-features-from-t1-weighted-images
#9
Ryuichi Fujimoto, Chihiro Kondo, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki, Ryuichi Fujimoto, Chihiro Kondo, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki, Koichi Ito, Yasuyuki Taki, Takafumi Aoki, Chihiro Kondo, Kazunori Sato, Hiroshi Fukuda, Ryuichi Fujimoto, Kai Wu
This paper proposes a simple method of selecting effective brain local features for age estimation from T1-weighted MR images. We also employ the high-resolution AAL atlas, which is defined by 1,024 local regions, to improve the accuracy of age estimation. We evaluate performance of the proposed method using 1,099 T1-weighted images from a large-scale brain MR image database of healthy Japanese, and demonstrate that the proposed method exhibits efficient performance of age estimation compared with conventional methods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28187320/mechanical-and-biological-behavior-of-ultrafine-grained-ti-alloy-aneurysm-clip-processed-using-high-pressure-torsion
#10
Ho Yong Um, Byung Ho Park, Dong-Hyun Ahn, Mohamed Ibrahim Abd El Aal, Jaechan Park, Hyoung Seop Kim
Severe plastic deformation (SPD) has recently been advanced as the main process for fabricating bulk ultrafine grained or nanocrystalline metallic materials, which present much higher strength and better bio-compatibility than coarse-grained counterparts. Medical devices, such as aneurysm clips and dental implants, require high mechanical and biological performance (e.g., stiffness, yield strength, fatigue resistance, and bio-compatibility). These requirements match well the characteristics of SPD-processed materials...
February 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28159012/identification-of-micrornas-expressed-in-the-midgut-of-aedes-albopictus-during-dengue-infection
#11
Jianxin Su, Chunxiao Li, Yingmei Zhang, Ting Yan, Xiaojuan Zhu, Minghui Zhao, Dan Xing, Yande Dong, Xiaoxia Guo, Tongyan Zhao
BACKGROUND: The midgut is the first barrier to dengue virus (DENV) infections of mosquitoes and therefore is a major bottleneck for the subsequent development of vector competence. However, the molecular mechanisms responsible for this barrier are unknown. RESULTS: We constructed three small RNA libraries from the midguts of adult Aedes albopictus females that had been fed on either sugar solution, an uninfected blood meal, or a blood meal infected with DENV-2, and112 conserved microRNAs represented by 173 miRNA sequences were identified, with 34 novel microRNAs predicted by Mireap, RNAfold and Sfold software...
February 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28154795/connectomic-profile-and-clinical-phenotype-in-newly-diagnosed-glioma-patients
#12
Jolanda Derks, Anne R Dirkson, Philip C de Witt Hamer, Quinten van Geest, Hanneke E Hulst, Frederik Barkhof, Petra J W Pouwels, Jeroen J G Geurts, Jaap C Reijneveld, Linda Douw
Gliomas are primary brain tumors, originating from the glial cells in the brain. In contrast to the more traditional view of glioma as a localized disease, it is becoming clear that global brain functioning is impacted, even with respect to functional communication between brain regions remote from the tumor itself. However, a thorough investigation of glioma-related functional connectomic profiles is lacking. Therefore, we constructed functional brain networks using functional MR scans of 71 glioma patients and 19 matched healthy controls using the automated anatomical labelling (AAL) atlas and interregional Pearson correlation coefficients...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28131026/preparation-and-characterization-of-ph-responsive-polyacrylamide-molecularly-imprinted-polymer-application-to-isolation-of-recombinant-and-wild-type-human-serum-albumin-from-biological-sources
#13
May A Abd El-Aal, Medhat A Al-Ghobashy, Faten Abdel Aziz Fathalla, Yasser S El-Saharty
In this work pH-responsive neutral and cationic polyacrylamide molecularly imprinted polymers (nMIP and cMIP, respectively) were prepared for separation of recombinant and wild type human serum albumin (HSA, pI 4.7) using mixture of polymerization initiators. The effect of pH during preparation and adsorption stages at pI(HSA)±2.0 on binding capacity and selectivity; imprinting factor (IF) was thoroughly investigated. SE-HPLC and RP-HPLC were employed for thorough evaluation of the stability of HSA at the studied experimental conditions and for simultaneous determination of HSA and erythropoietin (EPO) in their mixtures, respectively...
January 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28125912/olfactory-network-differences-in-master-sommeliers-connectivity-analysis-using-granger-causality-and-graph-theoretical-approach
#14
Karthik Sreenivasan, Xiaowei Zhuang, Sarah J Banks, Virendra Mishra, Zhengshi Yang, Gopikrishna Deshpande, Dietmar Cordes
Previous studies investigating the differences in olfactory processing and judgments between trained sommeliers and controls have shown increased activations in brain regions involving higher level cognitive processes in sommeliers. However, there is little information about the influence of expertise on causal connectivity and topological properties of the connectivity networks between these regions. Therefore, the current study focuses on addressing these questions in a functional magnetic resonance imaging (fMRI) study of olfactory perception in Master Sommeliers...
March 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28117314/benzotriazole-mediated-synthesis-and-antibacterial-activity-of-novel-n-acylcephalexins
#15
Khalid A Agha, Nader E Abo-Dya, Tarek S Ibrahim, Eatedal H Abdel-Aal, Wael A Hegazy
Cephalexin (1) was acylated using N-acylbenzotriazoles (3a-k') derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%-96%). Antibacterial screening of the novel cephalosporins revealed that all targets (4a-j) retained the antibacterial activity of cephalexin against Staphylococcus aureus (ATCC 6538). N-Nicotinylcephalexin (4c) and N-(3,4,5-trimethoxybenzoyl)cephalexin (4g) exhibited a broader spectrum of antibacterial activity towards standard strains of Staphylococcus aureus (ATCC 6538), Paenibacillus polymyxa (ATCC 842), and Escherichia coli (ATCC 10536) as well as a resistant strain of Pseudomonas aeruginosa (ATCC 27853)...
April 13, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28114031/classification-of-alzheimer-s-disease-using-whole-brain-hierarchical-network
#16
Jin Liu, Min Li, Wei Lan, Fang-Xiang Wu, Yi Pan, Jianxin Wang
Regions of interest (ROIs) based classification has been widely investigated for analysis of brain magnetic resonance imaging (MRI) images to assist the diagnosis of Alzheimer's disease (AD) including its early warning and developing stages, e.g., mild cognitive impairment (MCI) including MCI converted to AD (MCIc) and MCI not converted to AD (MCInc). Since an ROI representation of brain structures is obtained either by pre-definition or by adaptive parcellation, the corresponding ROI in different brains can be measured...
December 2, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28098103/relation-of-fibroblast-growth-factor-23-and-cardiovascular-calcification-in-end-stage-kidney-disease-patients-on-regular-hemodialysis
#17
Tarek Zakaria El Baz, Osama Ahmed Khamis, Osama Ashry Ahmed Gheith, Salama Saad Abd Ellateif, Abdallah Mahmoud Abdallah, Hussein Chahine Abd El Aal
More than half of deaths in end-stage kidney disease (ESKD) patients are due to cardiovascular disease. Elevated fibroblast growth factor 23 (FGF-23) was found to be associated with mortality in hemodialysis (HD) patients and correlates with peripheral calcification. Aortic calcification is associated with coronary artery calcification. Both aortic and peripheral vascular calcifications were associated with mortality in chronic kidney disease. We aimed to investigate the relation between intact FGF-23 and cardiovascular calcification in patients with ESKD who were maintained on regular HD...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28068596/evaluation-of-the-effectiveness-of-low-dose-aspirin-and-omega-3-in-treatment-of-asymmetrically-intrauterine-growth-restriction-a-randomized-clinical-trial
#18
Mohammed K Ali, Maggy E Amin, Ahmed F Amin, Diaa Eldeen M Abd El Aal
OBJECTIVE: To test the effect of aspirin and omega 3 on fetal weight as well as feto-maternal blood flow in asymmetrical intrauterine growth restriction (IUGR). STUDY DESIGN: This study is a clinically registered (NCT02696577), open, parallel, randomized controlled trial, conducted at Assiut Woman's Health Hospital, Egypt including 80 pregnant women (28-30 weeks) with IUGR. They were randomized either to group I: aspirin or group II: aspirin plus omega 3. The primary outcome was the fetal weight after 6 weeks of treatment...
January 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28040121/sublingual-misoprostol-versus-intravenous-oxytocin-in-reducing-bleeding-during-and-after-cesarean-delivery-a-randomized-clinical-trial
#19
Essam Rashad Othman, Margaret Fathy Fayez, Diaa Eldeen Mohamed Abd El Aal, Hazem Saad El-Dine Mohamed, Ahmed Mohammed Abbas, Mohammed Khairy Ali
OBJECTIVE: This study compares the efficacy of sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery. MATERIALS AND METHODS: A randomized clinical trial conducted on 120 pregnant women at term (37-40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either sublingual misoprostol 400 μg or intravenous infusion of 20 units of oxytocin after delivery of the neonate. The main outcome measures were blood loss at and 2 hours after cesarean delivery, change in hematocrit value, need for any additional oxytocic drugs, and drug-related side effects...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28029136/application-of-lectin-array-technology-for-biobetter-characterization-its-correlation-with-fc%C3%AE-riii-binding-and-adcc
#20
Markus Roucka, Klaus Zimmermann, Markus Fido, Andreas Nechansky
Lectin microarray technology was applied to compare the glycosylation pattern of the monoclonal antibody MB311 expressed in SP2.0 cells to an antibody-dependent cellular cytotoxic effector function (ADCC)-optimized variant (MB314). MB314 was generated by a plant expression system that uses genetically modified moss protoplasts (Physcomitrella patens) to generate a de-fucosylated version of MB311. In contrast to MB311, no or very low interactions of MB314 with lectins Aspergillus oryzae l-fucose (AOL), Pisum sativum agglutinin (PSA), Lens culinaris agglutinin (LCA), and Aleuria aurantia lectin (AAL) were observed...
December 24, 2016: Microarrays
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