keyword
https://read.qxmd.com/read/38509496/prevalence-and-factors-associated-with-hepatitis-b-vaccination-uptake-and-completion-among-communities-targeted-for-mass-vaccination-in-gulu-a-cross-sectional-study
#21
JOURNAL ARTICLE
Andrew Kimera, Lynn Atuyambe, Huzaifa Mutyaba, Claire Nantongo, Agnes Namagembe, Anna Maria Nalumansi, Andrew Basenero, Prisca Auma, Nelson Mukiza, Joan Mutyoba
BACKGROUND: Hepatitis B virus (HBV) is associated with several acute and long-term complications and vaccination is the cornerstone of prevention. A recent outbreak in Gulu, Uganda, one of the districts covered by a mass vaccination campaign, suggests low uptake of HBV vaccination. This study aims to determine the uptake and completion of HBV vaccination and associated factors among residents of Gulu, Uganda. METHODS: A mixed methods cross-sectional study was conducted in Gulu, Northern Uganda, among 434 adult residents...
March 20, 2024: BMC Public Health
https://read.qxmd.com/read/38506300/hepatitis-b-and-c-infections-among-japanese-dental-health-workers-insights-from-vaccination-rates-and-screening-results-in-the-oita-prefecture
#22
JOURNAL ARTICLE
Yumiko Nagao, Tetsuya Kimura, Kiyohide Tomooka, Haruhiko Wakita
OBJECTIVE: This study examined the hepatitis B virus (HBV) and hepatitis C virus (HCV) infection rates and vaccination rates for hepatitis B (HB) among dental healthcare workers (DHCWs) in the Oita prefecture, Japan. METHODS: Hepatitis virus testing was conducted on 1920 participants (486 dentists and 1434 dental staff). Anonymous data on age, gender, occupation, hepatitis B surface antigen (HBsAg), antibodies to hepatitis B surface antigen (anti-HBs), antibodies to HCV (anti-HCV), history of HB vaccination, and antiviral treatment for individuals with positive anti-HCV were collected...
April 2024: Clinical and Experimental Dental Research
https://read.qxmd.com/read/38505784/factors-associated-with-knowledge-and-awareness-of-hepatitis-b-in-individuals-of-chinese-descent-results-from-a-mass-point-of-care-testing-and-outreach-campaign-in-toronto-canada
#23
JOURNAL ARTICLE
Andrew B Mendlowitz, Erin Mandel, Camelia I Capraru, Bettina E Hansen, David Wong, Jordan J Feld, Harry LA Janssen, Mia J Biondi, Ambreen Arif, Colina Yim
BACKGROUND: Migrants from hepatitis B virus (HBV) endemic regions are at high risk of having chronic infection. Despite this, HBV knowledge and awareness programming, and low-barrier screening methods such as point of care (POC) testing, among this group have yet to become routine. METHODS: We conducted a mass HBV POC screening and knowledge and awareness campaign for individuals of Chinese descent in Toronto, Canada. POC screening was administered, then participants completed a knowledge questionnaire...
February 2024: Canadian liver journal
https://read.qxmd.com/read/38505249/effects-of-maternal-health-during-pregnancy-and-child-immunization-on-mother-to-child-transmission-of-hepatitis-b-virus-a-multicentre-large-sample-study-in-southeast-china
#24
JOURNAL ARTICLE
Xin-Xin Huang, Quan Lin, Yun Li, Li Li
PURPOSE: High hepatitis B infection rates in China are a major public health issue, and mother-to-child transmission (MTCT) is a significant risk factor. PATIENTS AND METHODS: This study was conducted with a prospective multicentre design from January 2021 to December 2022 in 245 hospitals providing midwifery services in southeastern China. The participants were pregnant women who were positive for hepatitis B surface antigen (HBs Ag) and their children. The HBs Ag concentration was tested in children aged 8-12 months...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38503757/design-of-hepadnavirus-core-protein-based-chimeric-virus-like-particles-carrying-epitopes-from-respiratory-syncytial-virus
#25
JOURNAL ARTICLE
Shuai Shao, Xue Feng Zhang, Jun Wei Hou, Sen Sen Yang, Zi Bo Han, Hai Lan Wu, Fang Tang, Xin Yu Li, Ze Hua Lei, Zi Xin Zhao, Shu Xiang Li, Zhao Ming Liu, Pu Shan, Yu Qin Jin, Ji Guo Su, Yu Liang, Jing Zhang, Qi Ming Li
Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, especially in infants and the elderly. The identification and structural resolution of the potent neutralizing epitopes on RSV fusion (F) protein enable an "epitope-focused" vaccine design. However, the display of RSV F epitope II on the surface of the widely-used human hepatitis B virus core antigen (HBcAg) has failed to induce neutralizing antibody response in mice. Here, we used the hepadnavirus core protein (HcAg) from different mammalian hosts as scaffolds to construct chimeric virus-like particles (VLPs) presenting the RSV F epitope II...
March 19, 2024: NPJ Vaccines
https://read.qxmd.com/read/38503664/cho-cells-for-virus-like-particle-and-subunit-vaccine-manufacturing
#26
REVIEW
Zalma V Sanchez-Martinez, Sergio P Alpuche-Lazcano, Matthew Stuible, Yves Durocher
Chinese Hamster Ovary (CHO) cells, employed primarily for manufacturing monoclonal antibodies and other recombinant protein (r-protein) therapeutics, are emerging as a promising host for vaccine antigen production. This is exemplified by the recently approved CHO cell-derived subunit vaccines (SUV) against respiratory syncytial virus (RSV) and varicella-zoster virus (VZV), as well as the enveloped virus-like particle (eVLP) vaccine against hepatitis B virus (HBV). Here, we summarize the design, production, and immunogenicity features of these vaccine and review the most recent progress of other CHO-derived vaccines in pre-clinical and clinical development...
March 18, 2024: Vaccine
https://read.qxmd.com/read/38503233/vaccination-coverage-among-people-who-inject-drugs-a-systematic-review
#27
REVIEW
Olivia Price, Rosie Swanton, Jason Grebely, Behzad Hajarizadeh, Paige Webb, Amy Peacock, Gregory J Dore, Benjamin C Cowie, Peter Vickerman, Louisa Degenhardt
BACKGROUND: People who inject drugs may be at excess risk of acquiring vaccine-preventable diseases and negative associated health outcomes, but experience barriers to vaccination. We aimed to determine vaccination coverage among people who inject drugs globally. METHODOLOGY: We conducted systematic searches of the peer-reviewed and grey literature, date limited from January 2008 to August 2023, focusing on diseases for which people who inject drugs are at elevated risk for and for which an adult vaccination dose is recommended (COVID-19, hepatitis A, hepatitis B, human papillomavirus, influenza, pneumococcal disease, tetanus)...
March 18, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38501993/hepatitis-a-virus-infection-in-cynomolgus-monkeys-confounds-the-safety-evaluation-of-a-drug-candidate
#28
JOURNAL ARTICLE
Chris J Powell, John C Kapeghian, John C Bernal, John R Foster
In a 3-month toxicity study in cynomolgus monkeys at a European contract laboratory, animals were infected with HAV, initially resulting in hepatic injury being incorrectly attributed to the test compound. Elevated serum ALT/AST/GLDH (5- to 10-fold) were noted in individual animals from all groups including controls, with no apparent dose, exposure, or time-related relationship. Liver histopathology revealed minimal to slight inflammatory cell accumulation in periportal zones of most animals, and minimal to slight hepatocyte degeneration/necrosis in 10/42 animals from all groups...
March 19, 2024: International Journal of Toxicology
https://read.qxmd.com/read/38501772/evaluation-of-a-catch-up-strategy-for-the-vaccination-in-patients-with-hepatitis-c-virus
#29
JOURNAL ARTICLE
María Fernández-Prada, Andrea Fraga-Pérez, Paula Cienfuegos-González, María José Zapico-Baragaño, José Miguel Brea-Corral, Adrián Huergo-Fernández
Vaccination in patients with advanced chronic liver disease (ACLD) is an essential part of their comprehensive healthcare. These individuals may have impaired phagocytic function and diminished production of opsonizing antibodies, resulting in increased susceptibility to bacterial infections, particularly pneumococcal pneumonia. Similarly, there is an increased risk of fulminant hepatitis due to hepatitis A and B viruses. The Ministry of Health updated specific vaccination recommendations for this group in 2018...
March 19, 2024: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/38500775/hepatitis-b-virus-infection-on-kwajalein-atoll-marshall-islands-a-seroprevalence-knowledge-and-attitudes-study
#30
JOURNAL ARTICLE
Melaia Lawanivalu, Anaseini Ratu, Glorine A Jeadrik, Masoud Mohammadnezhad, Aneley Getahun Strobel
OBJECTIVE: A study was conducted to determine the seroprevalence of chronic hepatitis B virus (HBV) infection among children and their mothers on Kwajalein Atoll in the Marshall Islands two decades after routine vaccination was introduced in the 1990s. Mothers' knowledge and attitudes towards HBV disease and vaccination were also assessed. METHODS: Results of a national seroprevalence survey conducted in 2016-2017 and antenatal records were used to determine the prevalence of HBV seropositivity in children aged 6-8 years and their biological mothers...
2024: Western Pacific Surveillance and Response Journal: WPSAR
https://read.qxmd.com/read/38499512/hyperoside-inhibits-ehv-8-infection-via-alleviating-oxidative-stress-and-ifn-production-through-activating-jnk-keap1-nrf2-ho-1-signaling-pathways
#31
JOURNAL ARTICLE
Tongtong Wang, Leyu Hu, Ruibo Li, Huiying Ren, Shuwen Li, Qi Sun, Xiangdan Ding, Yubao Li, Changfa Wang, Liangliang Li
Equine herpesvirus type 8 (EHV-8) causes abortion and respiratory disease in horses and donkeys, leading to serious economic losses in the global equine industry. Currently, there is no effective vaccine or drug against EHV-8 infection, underscoring the need for a novel antiviral drug to prevent EHV-8-induced latent infection and decrease the pathogenicity of this virus. The present study demonstrated that hyperoside can exert antiviral effects against EHV-8 infection in RK-13 (rabbit kidney cells), MDBK (Madin-Darby bovine kidney), and NBL-6 cells (E...
March 20, 2024: Journal of Virology
https://read.qxmd.com/read/38497081/amino-acid-pattern-reveals-multi-functionality-of-orf3-protein-from-hev
#32
JOURNAL ARTICLE
Zoya Shafat, Asimul Islam, Shama Parveen
The smallest open reading frame (ORF) encoded protein ORF3 of hepatitis E virus (HEV), recently, has been demonstrated to perform multiple functions besides accessory roles. ORF3 could act as a target for vaccine against HEV infections. The IDR (intrinsically disordered region); IDP (ID protein)/IDPR (ID protein region), plays critical role in various regulatory functions of viruses. The dark proteome of HEV-ORF3 protein including its structure and function was systematically examined by computer predictors to explicate its role in viral pathogenesis and drug resistance beyond its functions as accessory viral protein...
2024: Bioinformation
https://read.qxmd.com/read/38496080/evaluation-of-the-general-population-s-knowledge-concerning-liver-health-a-cross-sectional-study
#33
JOURNAL ARTICLE
Hidar Alibrahim, Haidara Bohsas, Sarya Swed, Khaled Albakri, Yossef H AbdeQadir, Sara Ramadan, Lazaward Kazan, Heba Haj Saleh, Fatema Ali Asgar Tashrifwala, Mohamad Al Ibrahim, Sabine Tayfour, Touka Abo Alsel, Abdullah Alnehlawi, Ubaid Khan, Ashraf N B Boktor, Ibrahim Elbialy, Hekmieh Manad, Reem Rizk Abazid, Wael Hafez
INTRODUCTION: Liver disease is among the leading causes of global mortality and morbidity. Given their substantial impact on public health, raising awareness about liver diseases is paramount for their prevention and effective management. This study aimed to evaluate the knowledge, awareness, attitudes, and behaviors of Syrians regarding liver health, chronic liver disorders, and their associated serious and irreversible complications. METHODS: We conducted a cross-sectional study encompassing the adult Syrian population between August 25 and September 29, 2023, excluding non-Syrians and individuals below the age of 18 years...
February 2024: Curēus
https://read.qxmd.com/read/38495649/cytokine-il-5-and-hgf-combined-prediction-of-non-low-immune-response-to-hepatitis-b-vaccination-at-birth-in-infants-born-to-hbsag-positive-mothers
#34
JOURNAL ARTICLE
Guanyong Ou, Ling Qing, Li Zhang, Yang Yang, Guoguo Ye, Ling Peng, Yanjie Li, Liuqing Yang, Yingxia Liu
BACKGROUND: The immune response to hepatitis B vaccine may be influenced by numerous factors, and patients with non/low response re-exposed to hepatitis B virus remain susceptible. Thus, a better understanding of the underlying mechanisms of non/low immune response in infants born to Hepatitis B surface antigen (HBsAg)-positive mothers is essential. METHODS: 100 infants born to HBsAg-positive mothers from 2015 to 2020 were enrolled in the study, further divided into the non/low response group (n=13) and the moderate strong response group (n=87) based on the quantification of hepatitis B surface antibody at 12 months of age...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38495283/changes-in-the-etiology-of-liver-cirrhosis-and-the-corresponding-management-strategies
#35
EDITORIAL
Jin-Jin Dai, Yue-Ying Liu, Zhen-Hua Zhang
We read with interest the article by Xing Wang, which was published in the recent issue of the World Journal of Hepatology 2023; 15: 1294-1306. This article focuses particularly on the prevalence and trends in the etiology of liver cirrhosis (LC), prognosis for patients suffering from cirrhosis-related complications and hepatocellular carcinoma (HCC), and management strategies. The etiology of cirrhosis varies according to geographical, economic, and population factors. Viral hepatitis is the dominant cause in China...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38494878/prognostic-value-of-an-immune-long-noncoding-rna-signature-in-liver-hepatocellular-carcinoma
#36
JOURNAL ARTICLE
Rui Kong, Nan Wang, Chun Li Zhou, Jie Lu
In recent years, there has been a growing recognition of the important role that long non-coding RNAs (lncRNAs) play in the immunological process of hepatocellular carcinoma (LIHC). An increasing number of studies have shown that certain lncRNAs hold great potential as viable options for diagnosis and treatment in clinical practice. The primary objective of our investigation was to devise an immune lncRNA profile to explore the significance of immune-associated lncRNAs in the accurate diagnosis and prognosis of LIHC...
January 30, 2024: Journal of Microbiology and Biotechnology
https://read.qxmd.com/read/38494314/exploring-awareness-and-prevalence-of-chronic-viral-hepatitis-in-a-uk-based-nepali-population-lessons-learned-for-future-models-in-engaging-migrant-communities
#37
JOURNAL ARTICLE
Claire Kelly, Sanju Mathew, Mihaela Petrova, Shuja Shafi, Margot Nicholls, Osman Dar, Jeewaka Mendis, Simon de Lusignan, Jane Hendy, Aftab Ala
INTRODUCTION: The burden of chronic viral hepatitis (CVH) in the UK Nepali population is unknown. We aimed to determine knowledge of liver disease (LD) and prevalence of CVH in this community. METHODS: This was a mixed method (qualitative and quantitative) study guided by a multidisciplinary stakeholder group. Focus groups (FG) led by Nepali community leaders explored LD knowledge. Thereafter, a prospective community-based cohort study utilising dried-blood spot testing was conducted...
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/38491438/prevalence-of-vaccine-derived-hepatitis-b-surface-antibodies-in-children-and-adolescents-in-germany-results-from-a-population-based-survey-2014-2017
#38
JOURNAL ARTICLE
Ida Sperle, Sofie Gillesberg Lassen, Martin Schlaud, Achim Dörre, Sandra Dudareva, Christina Poethko-Müller, Thomas Harder
INTRODUCTION: Childhood vaccination against hepatitis B has been recommended in Germany since 1995. WHO defines a primary vaccination series as successful if the initial hepatitis B surface antibody (anti-HBs) level is ≥ 10 IU/L directly after vaccination. Anti-HBs levels vary depending on the number of doses, type of vaccine, and time interval between the last two doses. In 2021, Germany began to recommend three instead of four doses of polyvalent hepatitis-B-containing vaccines...
March 15, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38486298/a-systematic-review-of-the-effects-of-hepatitis-b-and-c-virus-on-the-progression-of-liver-fluke-infection-to-liver-cancer
#39
REVIEW
Allison O'Rourke
Hepatitis B and C virus, Opisthorchis viverrini and Clonorchis sinensis, are all individually known to put a person at increased risk for cholangiocarcinoma and hepatocellular carcinoma. This paper seeks to determine if there is any interaction between liver flukes and hepatitis virus infection that are known to put a person at an increased risk for cholangiocarcinoma and hepatocellular carcinoma collectively. This paper seeks to determine whether there is any publicly available articles in English that determine if having a hepatitis viral co-infection along with liver flukes would influence the risk of developing liver cancer...
March 15, 2024: Tropical Diseases, Travel Medicine and Vaccines
https://read.qxmd.com/read/38485425/estimating-the-health-effects-of-covid-19-related-immunisation-disruptions-in-112-countries-during-2020-30-a-modelling-study
#40
JOURNAL ARTICLE
Anna-Maria Hartner, Xiang Li, Susy Echeverria-Londono, Jeremy Roth, Kaja Abbas, Megan Auzenbergs, Margaret J de Villiers, Matthew J Ferrari, Keith Fraser, Han Fu, Timothy Hallett, Wes Hinsley, Mark Jit, Andromachi Karachaliou, Sean M Moore, Shevanthi Nayagam, Timos Papadopoulos, T Alex Perkins, Allison Portnoy, Quan Tran Minh, Emilia Vynnycky, Amy K Winter, Holly Burrows, Cynthia Chen, Hannah E Clapham, Aniruddha Deshpande, Sarah Hauryski, John Huber, Kevin Jean, Chaelin Kim, Jong-Hoon Kim, Jemima Koh, Benjamin A Lopman, Virginia E Pitzer, Yvonne Tam, Philipp Lambach, So Yoon Sim, Kim Woodruff, Neil M Ferguson, Caroline L Trotter, Katy A M Gaythorpe
BACKGROUND: There have been declines in global immunisation coverage due to the COVID-19 pandemic. Recovery has begun but is geographically variable. This disruption has led to under-immunised cohorts and interrupted progress in reducing vaccine-preventable disease burden. There have, so far, been few studies of the effects of coverage disruption on vaccine effects. We aimed to quantify the effects of vaccine-coverage disruption on routine and campaign immunisation services, identify cohorts and regions that could particularly benefit from catch-up activities, and establish if losses in effect could be recovered...
April 2024: Lancet Global Health
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