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Vaccination hepatitis

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https://www.readbyqxmd.com/read/28231679/-use-the-markov-decision-tree-model-to-optimize-vaccination-strategies-of-hepatitis-e-among-women-aged-15-to-49
#1
Z M Chen, S B Ji, X L Shi, Y Y Zhao, X F Zhang, H Jin
Objective: To evaluate the cost-utility of different hepatitis E vaccination strategies in women aged 15 to 49. Methods: The Markov-decision tree model was constructed to evaluate the cost-utility of three hepatitis E virus vaccination strategies. Parameters of the models were estimated on the basis of published studies and experience of experts. Both methods on sensitivity and threshold analysis were used to evaluate the uncertainties of the model. Results: Compared with non-vaccination group, strategy on post-screening vaccination with rate as 100%, could save 0...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231660/-effect-of-telbivudine-on-infants-born-to-hbsag-positive-mothers-with-non-hypo-response-to-hepatitis-b-vaccine-during-their-second-and-third-trimesters-of-pregnancy
#2
X X Xu, B Wang, X F Wang, H X Wen, F Zhang, Z Q Yang, H Y Hao, T Wang, X H Shi, Z D Fu, B Wang, S P Wang
Objective: To explore the effect of telbivudine treatment in a prevention program on infants born to HBsAg-positive mothers with non-/hypo-responsiveness to hepatitis B vaccine. Methods: A retrospective cohort study with a total of 321 HBsAg-positive pregnant women and their infants enrolled, was conducted. The mothers were recruited from the Third People' s Hospital of Taiyuan, from July 2011 to January 2013. According to the situation of telbivudine intake in second and third trimesters of pregnancy, the participants were divided into two groups: with telbivudine-treated or as control...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231271/applying-antibody-sensitive-hypervariable-region-1-deleted-hepatitis-c-virus-to-the-study-of-escape-pathways-of-neutralizing-human-monoclonal-antibody-ar5a
#3
Rodrigo Velázquez-Moctezuma, Mansun Law, Jens Bukh, Jannick Prentoe
Hepatitis C virus (HCV) is a major cause of end-stage liver diseases. With 3-4 million new HCV infections yearly, a vaccine is urgently needed. A better understanding of virus escape from neutralizing antibodies and their corresponding epitopes are important for this effort. However, for viral isolates with high antibody resistance, or antibodies with moderate potency, it remains challenging to induce escape mutations in vitro. Here, as proof-of-concept, we used antibody-sensitive HVR1-deleted (ΔHVR1) viruses to generate escape mutants for a human monoclonal antibody, AR5A, targeting a rare cross-genotype conserved epitope...
February 23, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28228112/three-case-reports-of-post-immunization-and-post-viral-bullous-pemphigoid-looking-for-the-right-trigger
#4
Luca Baroero, Paola Coppo, Laura Bertolino, Stefano Maccario, Francesco Savino
BACKGROUND: Bullous pemphigoid (BP) is a blistering skin disorder infrequent in infancy and rarely reported in medical literature. CASE PRESENTATION: Here we describe three cases of BP which were referred to our department in the last 15 years. Two of them developed an eruption of bullous lesions just a few days after vaccination for diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B and Haemophilus influenzae B. The third patient developed the same blistering lesions shortly after herpetic stomatitis...
February 23, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28221166/prevalence-of-needlestick-injuries-attitude-changes-and-prevention-practices-over-12-years-in-an-urban-academic-hospital-surgery-department
#5
Jessica M Hasak, Christine B Novak, Jennifer Megan M Patterson, Susan E Mackinnon
OBJECTIVE: Needlestick injury prevalence, protection practices, and attitudes were assessed. Current medical students were compared with 2003 data to assess any changes that occurred with engineered safety feature implementation. BACKGROUND: Risk of occupational exposure to bloodborne pathogens is elevated in the operating room particularly with surgeons in training and nurses. METHODS: A cross-sectional survey was distributed to medical students (n = 358) and Department of Surgery staff (n = 247)...
February 17, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28221101/identification-of-a-novel-epitope-in-the-c-terminus-of-hcv-e2-protein-that-induces-potent-and-cross-reactive-neutralizing-antibodies
#6
Soma Das, Ranajoy Mullick, Anuj Kumar, Himani Tandon, Mihika Bose, K Gouthamchandra, Madhavi Chandra, Bagepally Ravishankar, M N Khaja, Narayanaswamy Srinivasan, Saumitra Das, Shaila Melkote Subbarao, Anjali Anoop Karande
Hepatitis C virus (HCV) is a leading cause of chronic viral hepatitis, but an effective vaccine is still not available to prevent infection. Use of neutralizing antibodies could be a potential therapeutic option. In this study, presence of anti-HCV antibodies in HCV-infected patients' was assessed from 50 patients and examined for the presence of neutralizing antibodies using the 'hepatitis C virus like particles'. Antibodies from two samples exhibited significant inhibitory activity suggesting that these may neutralize viral infection...
February 3, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28220812/status-of-hbsag-seroprevalence-in-15-million-rural-couples-in-china-a-cross-sectional-study
#7
Long Zhang, Yuan-Yuan Wang, Yan-Jie Huang, Qiao-Mei Wang, Kenrad E Nelson, An-Qi Wang, Hai-Ping Shen, Xiao-Li Liu, Yi-Ping Zhang, Dong-Hai Yan, Zuo-Qi Peng, Hong-Guang Zhang, Ya Zhang, Jun Zhao, Yan Wang, Ying Yang, Yuan He, Ji-Hong Xu, Du-Jia Liu, Tong-Jun Guo, Xiao-Na Xin, Hong Zhou, Xu Ma
A cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), were tested. Primary outcome of interest comprised HBsAg positivity in couples (both positive: F+M+, only wife positive: F+M-, only husband positive: F-M+), and secondary outcome consisted of prevalence and risk factors of HBsAg positivity among husbands or wives. Of 14,816,300 couples included, 0...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216554/harnessing-nanoparticles-for-immunomodulation-and-vaccines
#8
REVIEW
Ariane C Gomes, Mona Mohsen, Martin F Bachmann
The first successful use of nanoparticles (NPs) for vaccination was reported almost 40 years ago with a virus-like particle-based vaccine against Hepatitis B. Since then, the term NP has been expanded to accommodate a large number of novel nano-sized particles engineered from a range of materials. The great interest in NPs is likely not only a result of the two successful vaccines against hepatitis B and Human Papilloma Virus (HPV) that use this technology, but also due to the versatility of those small-sized particles, as indicated by the wide range of applications reported so far, ranging from medicinal and cosmetics to purely technical applications...
February 14, 2017: Vaccines
https://www.readbyqxmd.com/read/28215204/decreasing-the-hepatitis-b-burden-in-tunisia-need-more-attention-to-adults-for-vaccination
#9
H Chaouch, W Hachfi, A Letaief
No abstract text is available yet for this article.
February 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28209492/reproductive-considerations-in-the-setting-of-chronic-viral-illness
#10
REVIEW
Brent M Hanson, Jessie A Dorais
Special considerations must be taken when patients with human immunodeficiency virus (HIV), Hepatitis B, or Hepatitis C desire to achieve pregnancy. Patients with chronic viral illnesses desire children at rates similar to the general population, and options are available to decrease both vertical transmission and viral transmission between partners. Preconception counseling or consultation with fertility specialists is imperative in patients with HIV, Hepatitis B, and Hepatitis C so that reproductive goals can be addressed and optimized...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28208913/eosinophilic-granulomatosis-with-polyangiitis-egpa-and-hepatitis-b-infection-a-rare-association
#11
Nidhi Kaeley, Narula Kamakshi
Eosinophilic Granulomatosis with Polyangiitis (EGPA) or Churg-Strauss syndrome is a rare systemic illness which is characterized by necrotizing inflammation of small and medium sized vessels. The prominent features include asthma, eosinophilia, transient pulmonary infiltration and systemic vasculitis. Various triggering factors have been reported as putative aetiological agents of Churg-Strauss syndrome. They include infections, allergic desensitization, vaccinations like hepatitis B and influenza vaccination, cocaine abuse, drugs like leukotriene receptor antagonists and exposure to pigeons...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208753/possible-impact-of-190g-a-ccr2-and-%C3%AE-32-ccr5-mutations-on-decrease-of-the-hbv-vaccine-immunogenicity-a-preliminary-report
#12
Maria Ganczak, Karolina Skonieczna-Żydecka, Marzena Drozd-Dąbrowska, Grażyna Adler
Background: Chemokine genetic variations are involved in infectious diseases such as hepatitis B virus (HBV). Several allelic variants might, in theory, affect the outcome of vaccination. Objectives: This study was carried out to examine the associations of Δ32 CCR5 and 190G > A CCR2 polymorphisms with a response to a primary course of three HBV vaccinations. Methods: Between December 2014 and December 2016, patients from three randomly selected primary care clinics in the West Pomeranian region (Poland), 1 month after receiving the third dose of HBV vaccine, were enrolled...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28204523/evidence-for-hepatitis-a-virus-endemic-circulation-in-israel-despite-universal-toddler-vaccination-since-1999-and-low-clinical-incidence-in-all-age-groups
#13
Yosef Manor, Matthew Lewis, Daniela Ram, Nili Daudi, Orna Mor, Michal Savion, Zipi Kra-Oz, Yonat Shemer Avni, Rivka Sheffer, Daniel Shouval, Ella Mendelson
No abstract text is available yet for this article.
December 24, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28202090/decreasing-the-hepatitis-b-burden-in-tunisia-need-more-attention-to-adults-for-vaccination
#14
S M Alavian
No abstract text is available yet for this article.
February 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28202027/a-novel-pfs38-protein-complex-on-the-surface-of-plasmodium-falciparum-blood-stage-merozoites
#15
Gourab Paul, Arunaditya Deshmukh, Inderjeet Kaur, Sumit Rathore, Surbhi Dabral, Ashutosh Panda, Susheel Kumar Singh, Asif Mohmmed, Michael Theisen, Pawan Malhotra
BACKGROUND: The Plasmodium genome encodes for a number of 6-Cys proteins that contain a module of six cysteine residues forming three intramolecular disulphide bonds. These proteins have been well characterized at transmission as well as hepatic stages of the parasite life cycle. In the present study, a large complex of 6-Cys proteins: Pfs41, Pfs38 and Pfs12 and three other merozoite surface proteins: Glutamate-rich protein (GLURP), SERA5 and MSP-1 were identified on the Plasmodium falciparum merozoite surface...
February 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28199772/a-retrospective-study-of-hepatitis-b-mother-to-child-transmission-prevention-and-post-vaccination-serological-test-results-of-infants-at-risk-of-perinatal-transmission-in-two-counties-of-middle-china
#16
Guo Yonghao, Dong Pumei, Yang Jianhui, Xu Jin, Zhang Yanyang, Wang Zhe
Approximately 240 million people have chronic hepatitis B worldwide, with mother-to-child-transmission (MTCT) accounting for most cases. Therefore, Henan Province, China launched a public health program to prevent MTCT. To determine the efficacy of this health program, a survey was carried out in Huixian and Xinan counties, which are located in northern and western Henan. All infants born in these two counties between January 1, 2013 and March 31, 2014 to a mother positive for hepatitis B surface antigen (HBsAg), were surveyed; in total, there were 438 mother-infant pairs...
February 15, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28198787/serologic-responses-after-hepatitis-b-vaccination-in-preterm-infants-born-to-hepatitis-b-surface-antigen-positive-mothers-singapore-experience
#17
Tan Xt Christelle, Chan Si Min, Le Ye Lee, Christina Ong, Kong Boo Phua, Marion M Aw, Sharon Saw, Guan Huei Lee, Franco Wong, Koh Cheng Thoon
BACKGROUND: The Advisory Committee on Immunization Practices (ACIP) recommends a 4-dose vaccination schedule for preterm low birth weight infants (<2kg) and a 3-dose vaccination schedule for preterm infants (≥2kg) born to hepatitis B surface antigen (HBsAg) positive mothers. However, data remain limited for these high risk infants and the optimal dosing schedule in Asia is not well established. AIM: We aimed to evaluate the serologic vaccine responses in preterm infants born to HBsAg positive mothers using current vaccination guidelines...
February 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28198078/mutation-in-the-s-gene-of-hepatitis-b-virus-and-anti-hbs-subtype-nonspecificity-contributed-to-the-coexistence-of-hbsag-and-anti-hbs-in-patients-with-chronic-hepatitis-b-virus-infection
#18
Xiaochun Fu, Jing Chen, Huijuan Chen, Jinpiao Lin, Zhen Xun, Shiqi Li, Can Liu, Yongbin Zeng, Tianbin Chen, Bin Yang, Qishui Ou
The mechanism for the coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in chronic HBV infected patients remains controversial. This study aimed to explore the role of HBV S gene mutation and anti-HBs subtype-nonspecificity in patients with simultaneous HBsAg/anti-HBs positivity. Chronic HBV infections with (n = 145, group I) and without (n = 141, group II) anti-HBs were included. The S gene was amplified and sequenced. The neutralization experiment was used in group I patients' sera to determine the specificity of anti-HBs...
February 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28197802/effects-of-vaccine-acquired-polyclonal-anti-hbs-antibodies-on-the-prevention-of-hbv-infection-of-non-vaccine-genotypes
#19
Masaki Kato, Susumu Hamada-Tsutsumi, Chiaki Okuse, Aiko Sakai, Nobuyuki Matsumoto, Masaaki Sato, Toshiyuki Sato, Mitsumi Arito, Kazuki Omoteyama, Naoya Suematsu, Kazuki Okamoto, Takanobu Kato, Fumio Itoh, Ryo Sumazaki, Yasuhito Tanaka, Hiroshi Yotsuyanagi, Tomohiro Kato, Manae Suzuki Kurokawa
BACKGROUND: In universal hepatitis B (HB) vaccination, single vaccine-derived polyclonal anti-HBs antibodies (anti-HBs) need to inhibit infection of HB viruses (HBV) of non-vaccine genotypes. We experimentally addressed this issue. METHODS: Anti-HBs-positive sera were obtained by vaccination with genotype A- or C-derived HBs antigen (HBsAg, gtA-sera or gtC-sera). Their reactivity to genotype A- and C-derived HBsAg (gtA-Ag and gtC-Ag) was measured by ELISA. The capacity of sera to neutralize HBV was evaluated using an in vitro infection model...
February 14, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28197329/knowledge-current-status-and-barriers-toward-healthcare-worker-vaccination-among-family-medicine-resident-participants-in-a-web-based-survey-in-korea
#20
Kyungjin Ko, Sungjong Kim, Sang-Hyun Kim, Ki Young Son, Jungun Lee, Dong Ryul Lee
BACKGROUND: We investigated the knowledge, status, and barriers toward healthcare workers receiving vaccinations among Korean family medicine residents. To date, a systematic study has not been conducted among medical practitioners examining these variables. METHODS: A web-based, anonymous, self-administered questionnaire was distributed to all 942 family medicine residents working in 123 training hospitals in Korea. A multiple logistic regression analysis was performed to investigate factors affecting vaccination completion...
January 2017: Korean Journal of Family Medicine
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