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Sciatic neuropathy

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https://www.readbyqxmd.com/read/29674850/effect-of-dietary-oils-on-peripheral-neuropathy-related-endpoints-in-dietary-obese-rats
#1
Lawrence Coppey, Eric Davidson, Hanna Shevalye, Michael E Torres, Mark A Yorek
Purpose: This study aimed to determine the effect of dietary oils (olive, safflower, evening primrose, flaxseed, or menhaden) enriched in different mono unsaturated fatty acids or polyunsaturated fatty acids on peripheral neuropathies in diet-induced obese Sprague-Dawley rats. Materials and methods: Rats at 12 weeks of age were fed a high-fat diet (45% kcal) for 16 weeks. Afterward, the rats were fed diets with 50% of the kilocalories of fat derived from lard replaced by the different dietary oils...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29660653/antinociception-induced-by-rosuvastatin-in-murine-neuropathic-pain
#2
Hugo F Miranda, Fernando Sierralta, Nicolas Aranda, Paula Poblete, Rodrigo L Castillo, Viviana Noriega, Juan Carlos Prieto
BACKGROUND: Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to a lack of effective treatment. In two models of mouse neuropathic pain (PTX and PSNL) the antinociception induced by rosuvastatin and the participation of proinflammatory biomarkers, interleukin (IL)- 1β, TBARS and glutathione were evaluated. METHODS: A dose-response curve for rosuvastatin ip was obtained on cold plate, hot plate and Von Frey assays...
November 22, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29659424/utility-of-magnetic-resonance-imaging-for-predicting-severity-of-sciatic-nerve-injury
#3
Shivani Ahlawat, Allan J Belzberg, Laura M Fayad
OBJECTIVE: This study aimed to investigate the diagnostic accuracy of magnetic resonance (MR) imaging for categorizing sciatic peripheral nerve injury (PNI) as high-grade (Sunderland grades IV-V) or low-grade (Sunderland grades I-III) PNI. METHODS: In this institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study, consecutive MR imaging of the pelvis and thighs, performed for the evaluation of traumatic sciatic neuropathy, was reviewed for sciatic nerve signal intensity, size, architectural distortion, bulbous enlargement, perineural fibrosis, discontinuity, and muscle denervation changes...
April 13, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29656686/lipopolysaccharide-from-rhodobacter-sphaeroides-tlr4-antagonist-attenuates-hypersensitivity-and-modulates-nociceptive-factors
#4
Agnieszka M Jurga, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
CONTEXT: Accumulating evidence has demonstrated that Toll-like receptors (TLRs), especially TLR4 localized on microglia/macrophages, may play a significant role in nociception. OBJECTIVE: We examine the role of TLR4 in a neuropathic pain model. Using behavioural/biochemical methods, we examined the influence of TLR4 antagonist on levels of hypersensitivity and nociceptive factors whose contribution to neuropathy development has been confirmed. MATERIALS AND METHODS: Behavioural (von Frey's/cold plate) tests were performed with Wistar male rats after intrathecal administration of a TLR4 antagonist (LPS-RS ULTRAPURE (LPS-RSU), 20 μG: lipopolysaccharide from Rhodobacter sphaeroides, InvivoGen, San Diego, CA) 16 H and 1 h before chronic constriction injury (cci) to the sciatic nerve and then daily for 7 d...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29621478/hyperglycemia-induced-bcl-2-bax-mediated-apoptosis-of-schwann-cells-via-mtorc1-s6k1-inhibition-in-diabetic-peripheral-neuropathy
#5
Lin Zhu, Jun Hao, Meijuan Cheng, Cuihong Zhang, Chunxiu Huo, Yaping Liu, Wei Du, Xianghong Zhang
Schwann cell apoptosis is one of the characteristics of diabetic peripheral neuropathy (DPN). The mammalian target of rapamycin (mTOR) is a multifunctional signaling pathway that regulates cell apoptosis in various types of tissues and cells. To investigate whether the mTOR pathway is involved in cell apoptosis in the Schwann cells of DPN, diabetic mice and rat Schwann cells (RSC96) were chosen to detect phospho-mTOR (Ser 2448), phospho-S6K1 (Thr 389), phospho-4EBP1 (Thr 37/46), Bcl-2, Bax and cleaved caspase-3 by diverse pathological and biological techniques...
April 2, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29602762/insulin-induced-upregulation-of-lipoprotein-lipase-in-schwann-cells-during-diabetic-peripheral-neuropathy
#6
Kuruvanthe S Rachana, Mallahalli S Manu, Gopal M Advirao
Diabetic peripheral neuropathy (DPN) is one of the major complications associated with diabetes. It is characterized by the degeneration of the myelin sheath around axons, referred to as demyelination. Such demyelinations are often caused by reduced lipid component of the myelin sheath. Since, lipoprotein lipase (LPL) provides the lipid for myelin sheath by hydrolysing the triglyceride rich lipoproteins, and also helps in the uptake of lipids by the Schwann cells (SCs) for its utilization, LPL is considered as the important factor in the regeneration of myelin sheath during diabetic neuropathy...
March 17, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29599806/wentong-huoxue-cream-can-inhibit-the-reduction-of-the-pain-related-molecule-plc-%C3%AE-3-in-the-dorsal-root-ganglion-of-a-rat-model-of-diabetic-peripheral-neuropathy
#7
Chengcheng Feng, Lijuan Xu, Shiyun Guo, Qian Chen, Yuguo Shen, Deng Zang, Li Ma
WenTong HuoXue Cream (WTHX-Cream) has been shown to effectively alleviate clinical symptoms of diabetic peripheral neuropathy (DPN). This study investigated the gene and protein expression of the pain-related molecule PLC- β 3 in the dorsal root ganglion (DRG) of DPN rats. 88 specific pathogen-free male Wistar rats were randomly divided into placebo (10 rats) and DPN model (78 rats) groups, and the 78 model rats were used to establish the DPN model by intraperitoneal injection of streptozotocin and were then fed a high-fat diet for 8 weeks...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29596858/a-novel-histochemical-method-of-simultaneous-detection-by-a-single-or-double-immunofluorescence-and-bielschowsky-s-silver-staining-in-teased-rat-sciatic-nerves
#8
Edith Segura-Anaya, Rommel Flores-Miranda, Alejandro Martínez-Gómez, Myrna A R Dent
BACKGROUND: The Golgi silver method has been widely used in neuroscience for the study of normal and pathological morphology of neurons. The method has been steadily improved and Bielschowsky's silver staining method (BSSM) is widely used in various pathological conditions, like Alzheimer's disease. NEW METHOD: In this work, teased sciatic nerves were silver impregnated using BSSM. We also developed simultaneous staining by silver impregnation and single- or double-immunofluorescence of the same section in teased nerve preparations...
March 26, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29592782/resveratrol-enhances-il-4-receptor-mediated-anti-inflammatory-effects-in-spinal-cord-and-attenuates-neuropathic-pain-following-sciatic-nerve-injury
#9
Mu Xu, Zhigang Cheng, Zhuofeng Ding, Yunjiao Wang, Qulian Guo, Changsheng Huang
Resveratrol has been showed to relieve neuropathic pain through its anti-inflammatory effects on the peripheral nerve system. However, it is not clear whether resveratrol, especially when administered systemically, is effective in alleviating the peripheral neuropathy-induced imbalance between pro- and anti-inflammatory responses in the central nervous system. To test this, we used a rat neuropathic pain model resulting from chronic constriction injury of the sciatic nerve. Resveratrol (200 mg/kg) or vehicle (dimethylsulfoxide) were administered intraperitoneally once daily for 14 consecutive days after chronic constriction injury...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29581478/heparanase-attenuates-axon-degeneration-following-sciatic-nerve-transection
#10
Michael J Whitehead, Rhona McGonigal, Hugh J Willison, Susan C Barnett
Axon degeneration underlies many nervous system diseases; therefore understanding the regulatory signalling pathways is fundamental to identifying potential therapeutics. Previously, we demonstrated heparan sulphates (HS) as a potentially new target for promoting CNS repair. HS modulate cell signalling by both acting as cofactors in the formation of ligand-receptor complexes and in sequestering ligands in the extracellular matrix. The enzyme heparanase (Hpse) negatively regulates these processes by cleaving HS and releasing the attached proteins, thereby attenuating their ligand-receptor interaction...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29577893/participation-of-transient-receptor-potential-vanilloid-1-in-paclitaxel-induced-acute-visceral-and-peripheral-nociception-in-rodents
#11
Mateus Fortes Rossato, Flavia Karine Rigo, Sara Marchesan Oliveira, Gustavo Petri Guerra, Cássia Regina Silva, Thiago Mattar Cunha, Marcus Vinícius Gomez, Juliano Ferreira, Gabriela Trevisan
The clinical use of paclitaxel as a chemotherapeutic agent is limited by the severe acute and chronic hypersensitivity caused when it is administered via intraperitoneal or intravenous routes. Thus far, evidence has suggested that transient receptor potential vanilloid-1 (TRPV1) has a key role in the chronic neuropathy induced by paclitaxel. Despite this, the role of TRPV1 in paclitaxel -related acute nociception, especially the development of visceral nociception, has not been evaluated. Thus, the goal of this study was to evaluate the participation of TRPV1 in a model of acute nociception induced by paclitaxel in rats and mice...
March 22, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29572844/liraglutide-ameliorated-peripheral-neuropathy-in-diabetic-rats-involvement-of-oxidative-stress-inflammation-and-extracellular-matrix-remodeling
#12
Passant E Moustafa, Noha F Abdelkader, Sally A El Awdan, Osama A El-Shabrawy, Hala F Zaki
Diabetic peripheral neuropathy is one of the most common microvascular complications that occurs with both type 1 and type 2 diabetes mellitus. It has a significant negative impact on patients' quality of life; as it starts with loss of limbs' sensation and may lead to lower limb amputation. This study aimed at investigating the effect of liraglutide on peripheral neuropathy in diabetic rats. Experimental diabetes was induced by single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52...
March 23, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29563324/binding-characteristics-and-analgesic-effects-of-mirogabalin-a-novel-ligand-for-the-%C3%AE-2-%C3%AE-subunit-of-voltage-gated-calcium-channels
#13
Yuki Domon, Naohisa Arakawa, Tatsuya Inoue, Fumihiko Matsuda, Makoto Takahashi, Naotoshi Yamamura, Kiyonori Kai, Yutaka Kitano
Mirogabalin ([(1 R ,5 S ,6 S )-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid), a novel ligand for the α2 δ subunit of voltage-gated calcium channels, is being developed to treat pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. In the present study, we investigated the in vitro binding characteristics and in vivo analgesic effects of mirogabalin, compared to those of pregabalin, a standard α2 δ ligand. Mirogabalin showed potent and selective binding affinities for the α2 δ subunits, while having no effects on 186 off-target proteins...
March 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29560943/-spinal-mechanisms-of-neuroplasticity-induced-by-neuromidin-in-treatment-of-traumatic-neuropathies
#14
S A Zhivolupov, L S Onischenko, N A Rashidov, I N Samartsev, E V Jakovlev
AIM: To analyze the spinal mechanisms of neuroplastic changes induced by neuromidin (ipidacrine) in a model of traumatic axonotomy of the sciatic nerve in rats. MATERIAL AND METHODS: The histological study of the material from the anterior horn (lumbar portion of spinal cord) was performed in 6 rats using electron microscopy. RESULTS AND CONCLUSION: The comparative analysis of neuromorphological changes in rats of control and main groups revealed the neuroprotective and modifying effects of neuromidin on the spinal neuroplasticity...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29558999/acute-and-late-phase-matrix-metalloproteinase-mmp-9-activity-is-comparable-in-female-and-male-rats-after-peripheral-nerve-injury
#15
Albert G Remacle, Swathi K Hullugundi, Jennifer Dolkas, Mila Angert, Andrei V Chernov, Alex Y Strongin, Veronica I Shubayev
BACKGROUND: In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activity after nerve injury is sexually dimorphic remains unknown. METHODS: Patterns of MMP-9 expression, activity and excretion were assessed in a model of painful peripheral neuropathy, sciatic nerve chronic constriction injury (CCI), in female and male rats...
March 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29552083/danhong-injection-alleviates-mechanical-allodynia-via-inhibiting-erk1-2-activation-and-elevates-bdnf-level-in-sciatic-nerve-in-diabetic-rat
#16
Qi Wang, Zhuang-Li Guo, Ge-Le Aori, Da-Wei Kong, Wen-Qiang Yang, Li Zhang, Yan-Bing Yu
Danhong injection (DHI) has been widely used in China for cardiocerebrovascular diseases treatments. And in this study, we demonstrated the therapeutic effect of DHI on experimental diabetic neuropathy for the first time. Methods . Streptozotocin- (STZ-) induced SD rats were used. In experiment 1, 4-week treatment with DHI or saline started 4 weeks after STZ injection; mechanical allodynia was measured before and every 2 weeks after STZ injection. In experiment 2, chronic intrathecal infusion of U0126 was conducted during the 8th week of diabetes...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29550800/quercetin-in-association-with-moderate-exercise-training-attenuates-injuries-induced-by-experimental-diabetes-in-sciatic-nerves
#17
I C Chis, A Clichici, A L Nagy, A Oros, C Catoi, S Clichici
Diabetic neuropathy (DN) is a frequent, serious and debilitating chronic complication of diabetes mellitus (DM). Hyperglycemia, oxidative and nitrosative stress are involved in causing nerve damage in several animals, humans and experimental models of diabetes. This study was designed to investigate the synergistic cumulative neuroprotective effect of quercetin administration and moderate exercise training on sciatic nerves injuries in streptozotocin (STZ)-diabetic rats. DM was induced in Wistar rats by intraperitoneal administration of STZ (60 mg/kg)...
December 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29550371/transcriptional-networks-of-progressive-diabetic-peripheral-neuropathy-in-the-db-db-mouse-model-of-type-2-diabetes-an-inflammatory-story
#18
Lucy M Hinder, Benjamin J Murdock, Meeyoung Park, Diane E Bender, Phillipe D O'Brien, Amy E Rumora, Junguk Hur, Eva L Feldman
Diabetic peripheral neuropathy is the most common complication of diabetes and a source of considerable morbidity. Numerous molecular pathways are linked to neuropathic progression, but it is unclear whether these pathways are altered throughout the course of disease. Moreover, the methods by which these molecular pathways are analyzed can produce significantly different results; as such it is often unclear whether previously published pathways are viable targets for novel therapeutic approaches. In the current study we examine changes in gene expression patterns in the sciatic nerve (SCN) and dorsal root ganglia (DRG) of db/db diabetic mice at 8, 16, and 24 weeks of age using microarray analysis...
March 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29540747/bone-marrow-mesenchymal-stem-cells-protect-against-n-hexane-induced-neuropathy-through-beclin-1-independent-inhibition-of-autophagy
#19
Jie Hao, Shuangyue Li, Xiaoxia Shi, Zhiqiang Qian, Yijie Sun, Dunjia Wang, Xueying Zhou, Hongxin Qu, Shuhai Hu, Enjun Zuo, Cong Zhang, Liyan Hou, Qingshan Wang, Fengyuan Piao
Chronic exposure to n-hexane, a widely used organic solvent in industry, induces central-peripheral neuropathy, which is mediated by its active metabolite, 2,5-hexanedione (HD). We recently reported that transplantation of bone marrow-mesenchymal stem cells (BMSC) significantly ameliorated HD-induced neuronal damage and motor deficits in rats. However, the mechanisms remain unclear. Here, we reported that inhibition of HD-induced autophagy contributed to BMSC-afforded protection. BMSC transplantation significantly reduced the levels of microtubule-associated protein 1 light chain 3-II (LC3-II) and the degradation of sequestosome-1 (p62) in the spinal cord and sciatic nerve of HD-intoxicated rats...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29528965/evaluation-of-different-drug-classes-on-transient-sciatic-nerve-injury-depressed-marble-burying-in-mice
#20
Jenny L Wilkerson, Zachary A Curry, Pamela D Kinlow, Brittany L Mason, Ku-Lung Hsu, Mario van der Stelt, Benjamin F Cravatt, Aron H Lichtman
A great need exists for the identification of new effective analgesics to treat sustained pain. However, most preclinical nociceptive assays measure behavioral responses evoked by noxious stimuli (i.e., pain-stimulated behavior), which presents a challenge to distinguish between motor impairing and antinociceptive effects of drugs. Here, we demonstrate that chronic constriction injury of the sciatic nerve (CCI) elicits common pain-stimulated responses (i.e., mechanical allodynia and thermal hyperalgesia) as well as reduces marble burying/digging behaviors that occur during the early stages of the neuropathy and resolve within one week...
March 8, 2018: Pain
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