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https://www.readbyqxmd.com/read/29353397/patients-perceptions-of-pharmacist-managed-diabetes-services-in-the-ambulatory-care-and-community-settings-within-singapore
#1
Melanie Yee Lee Siaw, Jing Heng Toh, Joyce Yu-Chia Lee
Background Qualitative evidence on patients' perceptions of pharmacist-managed diabetes services (PMDSs) is limited. Objective To explore patients' perceptions of PMDSs Setting Patients being cared for in the outpatient settings in Singapore. Methods This focus group included patients who were diagnosed with type 2 diabetes, spoke either English or Mandarin, attended PMDSs for at least 6 months in the ambulatory care or community settings, and were at least 21 years of age. Patients with cognitive impairments or mobility issues were excluded...
January 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29352654/resistance-training-during-a-12-week-protein-supplemented-vlcd-treatment-enhances-weight-loss-outcomes-in-obese-patients
#2
Edward Jo, Phillip R Worts, Marcus L Elam, Ann Frost Brown, Andy V Khamoui, Do-Houn Kim, Ming-Chia Yeh, Michael J Ormsbee, Carla M Prado, Angelina Cain, Katie Snyder, Jeong-Su Kim
BACKGROUND: This investigation evaluated the efficacy by which resistance training enhances body composition, metabolic, and functional outcomes for obese patients undergoing a 12-week medically supervised hypocaloric treatment. METHODS: This was a single-blind, randomized, parallel-group prospective trial. Morbidly obese patients were prescribed a 12-week proprietary very low calorie diet (VLCD) treatment (Optifast®) with supplemental protein (1120 kcals/day) and were placed in one of two groups for 14 weeks: 1) Standard Treatment Control (CON) (n = 5) or 2) Resistance Training (RT) (n = 6)...
December 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29352475/characteristics-of-proanthocyanidins-in-leaves-of-chamaecyparis-obtusa-var-formosana-as-strong-%C3%AE-glucosidase-inhibitors
#3
Chia-Yun Hsu, Gong-Min Lin, Huan-You Lin, Shang-Tzen Chang
BACKGROUND: In recent decades there has been a growing demand for natural products with a view to using them as α-glucosidase inhibitors for reducing postprandial hyperglycemia. The hot water extract from Chamaecyparis obtusa var. formosana (Hayata) Rehder (Cupressaceae) (HWE) leaves and its soluble fractions were screened for α-glucosidase inhibition properties. The n-butanol soluble fraction of HWE was further fractionated into fourteen subfractions (B1-B14) using a Sephadex LH-20 column...
January 20, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29352406/does-biopsy-needle-traversing-through-central-portion-of-lesion-increase-the-risk-of-hemoptysis-during-percutaneous-transthoracic-needle-biopsy
#4
Chia-Hung Chen, Wei-Ming Huang, Shih-Hsuan Liang, Zong-Yi Jhou, Chien-Wen Chen, Yu-Chan Chien, Hui-Chen Lin, Chih-Hsin Wang, Chun-Chao Huang, Wei-Ni Liao, Chung-Yao Huang
PURPOSE: To evaluate whether traversal through the central part of a pulmonary lesion by a biopsy needle, and other factors, increases the risk of hemoptysis in patients undergoing CT-guided percutaneous transthoracic needle biopsy (PTNB). MATERIALS AND METHODS: From July 2012 to November 2016, 227 patients undergoing 233 procedures were recruited as our study population. Patients were classified according to the occurrence of hemoptysis. Radiological assessments were performed by reviewing multiplanar reconstructed CT images...
January 19, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29352331/transanal-total-mesorectal-excision-is-it-necessary-in-the-era-of-robots
#5
Li-Jen Kuo, James Chi-Yong Ngu, Chia-Che Chen
Transanal total mesorectal excision (taTME) has been proposed to overcome the limitations of laparoscopic TME. The robotic surgical platform has already established its benefits in providing superior ergonomics, and the purported advantages of taTME may play less important a role in the era of robots.
January 19, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29351918/personalized-chemosensitivity-assays-for-mesothelioma-is-it-worth-the-effort
#6
Thomas John, Puey Ling Chia
Cell-lines formed from an individual's tumor can be used to predict response to specific therapies and determine genomic predictors. For mesothelioma, where chemotherapy remains the backbone of current therapeutic paradigms, such assays could be used to treat patients with the most effective agents specific to their "chemical profile".
January 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29351555/omega-3-fatty-acid-desaturase-gene-family-from-two-%C3%AF-3-sources-salvia-hispanica-and-perilla-frutescens-cloning-characterization-and-expression
#7
Yufei Xue, Baojun Chen, Aung Naing Win, Chun Fu, Jianping Lian, Xue Liu, Rui Wang, Xingcui Zhang, Yourong Chai
Omega-3 fatty acid desaturase (ω-3 FAD, D15D) is a key enzyme for α-linolenic acid (ALA) biosynthesis. Both chia (Salvia hispanica) and perilla (Perilla frutescens) contain high levels of ALA in seeds. In this study, the ω-3 FAD gene family was systematically and comparatively cloned from chia and perilla. Perilla FAD3, FAD7, FAD8 and chia FAD7 are encoded by single-copy (but heterozygous) genes, while chia FAD3 is encoded by 2 distinct genes. Only 1 chia FAD8 sequence was isolated. In these genes, there are 1 to 6 transcription start sites, 1 to 8 poly(A) tailing sites, and 7 introns...
2018: PloS One
https://www.readbyqxmd.com/read/29351316/dexmedetomidine-reduces-lipopolysaccharide-induced-neuroinflammation-sickness-behavior-and-anhedonia
#8
Ching-Hua Yeh, Liang-Po Hsieh, Ming-Chung Lin, Tsui-Shan Wei, Hui-Ching Lin, Chia-Cheng Chang, Chung-Hsi Hsing
BACKGROUND: Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. MATERIALS AND METHODS: BALB/c mice were intraperitoneally (i.p.) injected with Dex (50 ug/kg) or vehicle. One hour later, the mice were injected (i...
2018: PloS One
https://www.readbyqxmd.com/read/29350774/hepatitis-b-virus-surface-gene-pre-s2-mutant-as-a-high-risk-serum-marker-for-hepatoma-recurrence-after-curative-hepatic-resection
#9
Chia-Jui Yen, Yu-Lin Ai, Hung-Wen Tsai, Shih-Huang Chan, Chia-Sheng Yen, Kuang-Hsiung Cheng, Yun-Ping Lee, Chia-Wei Kao, Yu-Chun Wang, Yi-Lin Chen, Cheng-Han Lin, Tsunglin Liu, Huey-Pin Tsai, Jen-Ren Wang, Ih-Jen Su, Wenya Huang
Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre-S2 mutant large HBV surface antigen (LHBS) is highly associated with HCC. This study aimed to analyze the expression of the large form of surface protein in tumors and to evaluate the LHBS with mutations within the pre-S2 region as a high-risk recurrence marker in HCC patients after curative hepatic resection. By the analyses of immunohistochemical staining (N = 12) and Western Blotting (N = 22), the HBV surface protein, which is mainly comprised of the major form of HBS, was greatly diminished in the tumors...
January 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29348649/publisher-correction-determination-of-total-and-unbound-docetaxel-in-plasma-by-ultrafiltration-and-uplc-ms-ms-application-to-pharmacokinetic-studies
#10
Ming-Thau Sheu, Chen-Yuan Wu, Chia-Yu Su, Hsiu-O Ho
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348363/atomic-resolution-transmission-electron-microscopy-of-electron-beam-sensitive-crystalline-materials
#11
Daliang Zhang, Yihan Zhu, Lingmei Liu, Xiangrong Ying, Chia-En Hsiung, Rachid Sougrat, Kun Li, Yu Han
High-resolution imaging of electron beam-sensitive materials is one of the most difficult applications of transmission electron microscopy (TEM). The challenges are manifold, including the acquisition of images with extremely low beam doses, the time-constrained search for crystal zone axes, the precise image alignment, and the accurate determination of the defocus value. We develop a suite of methods to fulfill these requirements and acquire atomic-resolution TEM images of several metal organic frameworks that are generally recognized as highly sensitive to electron beams...
January 18, 2018: Science
https://www.readbyqxmd.com/read/29348118/targeted-deletion-of-adipocyte-abca1-atp-binding-cassette-transporter-a1-impairs-diet-induced-obesity
#12
Helen Cuffe, Mingxia Liu, Chia-Chi C Key, Elena Boudyguina, Janet K Sawyer, Allison Weckerle, Alexander Bashore, Susan K Fried, Soonkyu Chung, John S Parks
OBJECTIVE: Adipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study was to evaluate the role of the cellular cholesterol exporter, Abca1 (ATP-binding cassette transporter A1), on adipose tissue function during diet-induced obesity. APPROACH AND RESULTS: Adiponectin Cre recombinase transgenic mice were crossed with Abca1flox/flox mice to generate ASKO (adipocyte-specific Abca1 knockout) mice...
January 18, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29346572/analysis-of-experience-regulated-transcriptome-and-imprintome-during-critical-periods-of-mouse-visual-system-development-reveals-spatiotemporal-dynamics
#13
Chi-Lin Hsu, Chih-Hsuan Chou, Shih-Chuan Huang, Chia-Yi Lin, Meng-Ying Lin, Chun-Che Tung, Chun-Yen Lin, Ivan Pochou Lai, Yan-Fang Zou, Neil A Youngson, Shau-Ping Lin, Chang-Hao Yang, Shih-Kuo Chen, Susan Shur-Fen Gau, Hsien-Sung Huang
Visual system development is light-experience dependent, which strongly implicates epigenetic mechanisms in light-regulated maturation. Among many epigenetic processes, genomic imprinting is an epigenetic mechanism through which monoallelic gene expression occurs in a parent-of-origin-specific manner. It is unknown if genomic imprinting contributes to visual system development. We profiled the transcriptome and imprintome during critical periods of mouse visual system development under normal- and dark-rearing conditions using B6/CAST F1 hybrid mice...
January 15, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29346486/treatment-outcomes-and-adverse-events-following-in-office-angiolytic-laser-with-or-without-concurrent-polypectomy-for-vocal-fold-polyps
#14
Yu-Hsuan Lin, Chi-Te Wang, Feng-Chuan Lin, Li-Jen Liao, Wu-Chia Lo, Po-Wen Cheng
Importance: In-office angiolytic laser procedures have been used successfully as an alternative treatment for vocal fold polyps; little is known in detail about the treatment outcomes and adverse events. Objective: To examine the outcomes and incidence rates of adverse events associated with in-office angiolytic laser procedures with or without concurrent polypectomy as an alternative treatment for vocal fold polyps. Design, Setting, and Participants: Retrospective cohort study at a tertiary medical center...
January 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29345776/allyl-isothiocyanate-ameliorates-obesity-by-inhibiting-galectin-12
#15
Chia-Wen Lo, Chih-Sheng Chen, Ying-Chi Chen, Yu-An Hsu, Chi-Chun Huang, Ching-Yao Chang, Chao-Jen Lin, Cheng-Wen Lin, Hui-Ju Lin, Fu-Tong Liu, Lei Wan
SCOPE: The aim of this study was to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. METHODS AND RESULTS: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by down-regulating key adipogenic transcription factors...
January 18, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29344589/magnetism-tuning-strategies-for-graphene-oxide-based-on-magnetic-oligoacene-oxide-patches-model
#16
Yanjie Wen, Chia-Liang Yen, Linyin Yan, Hirohiko Kono, Sheng-Hsien Lin, Yong-Chien Ling
Graphene oxide (GO) has wide application potential owing to its 2D structure and diverse modification sites for various targeted uses. The introduction of magnetism into GO structures has further advanced the controllability of the application of GO materials. Herein, the concept of modular design and modeling was applied to tune the magnetism of GO. To obtain desirable magnetic properties, diradical-structured GO patches were formed by the introduction of two functional groups to break the Kekule structure of the benzene ring...
January 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29344024/elevated-phosphate-levels-trigger-autophagy-mediated-cellular-apoptosis-in-h9c2-cardiomyoblasts
#17
Yao-Lung Liu, Kuan-Ho Lin, Shanmugam Tamilselvi, Wei-Kung Chen, Chia-Yao Shen, Ray-Jade Chen, Cecilia Hsuan Day, Hsi-Chin Wu, Vijaya Padma Viswanadha, Chih-Yang Huang
BACKGROUND/AIM: In chronic kidney disease (CKD), kidneys fail to maintain phosphorus homeostasis in serum. Elevated phosphorus levels in serum have been associated with cardiovascular diseases in CKD patients and in normal individuals. In this study, we evaluated the level of autophagy- and apoptosis-related markers under different concentrations of hyperphosphate in myocardial cells. METHODS: Modulation inflicted on the levels of various survival-, autophagy-, and apoptosis-related markers were determined by Western blotting analysis using total protein extract...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29343981/assessment-of-pain-score-and-specimen-adequacy-for-ultrasound-guided-fine-needle-aspiration-biopsy-of-thyroid-nodules
#18
Li-Jen Liao, Wu-Chia Lo, Wan-Lun Hsu, Po-Wen Cheng, Cheng-Ping Wang
Objective: The aim of this study was to evaluate pain scores and specimen adequacy for ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules without and with local anesthesia (LA). Materials and methods: The US-FNAB procedure was performed on 183 patients with and without LA. One puncture was made for solid nodules, and if patients could tolerate it, a two-puncture technique was used for nodules with a cystic change. Four-point verbal rating scores were assessed by a nursing assistant after completion of US-FNAB...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29343794/bone-regeneration-using-a-porcine-bone-substitute-collagen-composite-in-vitro-and-in-vivo
#19
Eisner Salamanca, Chia-Chen Hsu, Haw-Ming Huang, Nai-Chia Teng, Che-Tong Lin, Yu-Hwa Pan, Wei-Jen Chang
The biocharacteristics of xenogeneic grafts make them a possible substitute for autogenous bone grafts in dental bone graft procedures. This study aimed to develop a novel porcine graft with collagen capable of generating new bone in bone defects via osteoconduction over 8 weeks of healing and to compare it with a porcine graft. The porcine collagen graft was made to undergo a cell viability test (MTT) and alkaline phosphatase assay (ALP). The surgical procedure was performed in 20 male adult New Zealand white rabbits...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343786/algainp-red-leds-with-hollow-hemispherical-polystyrene-arrays
#20
Wen-Ching Cheng, Shih-Yung Huang, Yi-Jiun Chen, Chia-Sheng Wang, Hoang Yan Lin, Tzong-Ming Wu, Ray-Hua Horng
A hollow hemispherical polystyrene (HHPS) was fabricated to reduce total internal reflection in AlGaInP-based LEDs. At an injection current of 350 mA, the external quantum efficiencies of LED-I, LED-II, LED-III, and LED-IV are 20.92%, 24.65%, 27.28%, and 33.77% and the wall-plug efficiencies are 17.11%, 20%, 22.5%, and 27.33%, respectively. The enhanced performance is attributed to the light output power enhancement through the surface roughness, microlens-liked PS hemisphere, and scatter-liked HHPS array...
January 17, 2018: Scientific Reports
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