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https://www.readbyqxmd.com/read/28730511/intermediate-molecular-mass-hyaluronan-and-cd44-receptor-interactions-enhance-neutrophil-phagocytosis-and-il-8-production-via-p38-and-erk1-2-mapk-signalling-pathways
#1
Cheng-Hsun Lu, Chia-Huei Lin, Ko-Jen Li, Chieh-Yu Shen, Cheng-Han Wu, Yu-Min Kuo, Ting-Syuan Lin, Chia-Li Yu, Song-Chou Hsieh
CD44 is a common leukocyte adhesion molecule expressed on the surface of various cells. Hyaluronan (HA), the natural ligand of CD44, is a simple repeated disaccharide with variable molecular mass that is widely distributed on cell surfaces and the connective tissue matrix. The binding of small molecular mass HA (SMM-HA, MW < 80 kDa) to CD44 on immune-related cells elicits cell proliferation, differentiation, and cytokine production. However, the effects and molecular basis of intermediate molecular mass HA (IMM-HA, MW ≈ 500 kDa)-CD44 interactions on polymorphonuclear neutrophil (PMN) functions have not been elucidated...
July 20, 2017: Inflammation
https://www.readbyqxmd.com/read/28730488/absolute-phosphorylation-stoichiometry-analysis-by-motif-targeting-quantitative-mass-spectrometry
#2
Chia-Feng Tsai, Wei-Chi Ku, Yu-Ju Chen, Yasushi Ishihama
Direct measurement of site-specific phosphorylation stoichiometry can unambiguously distinguish whether the degree of phosphorylation is regulated by upstream kinase/phosphatase activity or by transcriptional regulation to alter protein expression level. Here, we describe a motif-targeting quantitative proteomic approach that integrates dephosphorylation, isotope tag labeling, and enzymatic kinase reaction for large-scale phosphorylation stoichiometry measurement of the human proteome.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730155/surveillance-study-of-influenza-occurrence-and-immunity-in-a-wisconsin-cohort-during-the-2009-pandemic
#3
Chia-Yun Lo, Susan L Strobl, Kimberly Dunham, Wei Wang, Lucy Stewart, Julia A Misplon, Mayra Garcia, Jin Gao, Tatsuhiko Ozawa, Graeme E Price, Jose Navidad, Steve Gradus, Sanjib Bhattacharyya, Cecile Viboud, Maryna C Eichelberger, Carol D Weiss, Jack Gorski, Suzanne L Epstein
BACKGROUND: Antibody and T-cell immunity to conserved influenza virus antigens can protect animals against infection with diverse influenza strains. Although immunity against conserved antigens occurs in humans, whether such responses provide cross-protection in humans and could be harnessed as the basis for universal influenza vaccines is controversial. The 2009 pandemic provided an opportunity to investigate whether pre-existing cross-reactive immunity affected susceptibility to infection...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28730114/diagnostic-capability-of-peripapillary-retinal-nerve-fiber-layer-parameters-in-time-domain-versus-spectral-domain-optical-coherence-tomography-for-assessing-glaucoma-in-high-myopia
#4
Mei-Ching Teng, Yi-Chieh Poon, Kuo-Chi Hung, Hsueh-Wen Chang, Ing-Chou Lai, Jen-Chia Tsai, Pei-Wen Lin, Chien-Yun Wu, Chueh-Tan Chen, Pei-Chang Wu
AIM: To evaluate and compare the diagnostic capabilities of peripapillary retinal nerve fiber layer (p-RNFL) parameters of Spectralis optical coherence tomography (OCT) versus Stratus OCT to detect glaucoma in patients with high myopia. METHODS: This is a retrospective, cross-sectional study. Sixty highly myopic eyes of 60 patients were enrolled, with 30 eyes in the glaucoma group and 30 eyes in the control group. All eyes received peripapillary imaging of the optic disc using Stratus and Spectralis OCT...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730070/inhibition-effect-of-curcumin-on-uvb-induced-secretion-of-pro-inflammatory-cytokines-from-corneal-limbus-epithelial-cells
#5
Shih-Chun Chao, Dan-Ning Hu, Joan Roberts, Xilun Shen, Chia-Yi Lee, Chan-Wei Nien, Hung-Yu Lin
AIM: To study the effects of curcumin on the secretion of interleukin (IL)-6 and IL-8 by corneal limbus epithelial cells. METHODS: Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different dosages with or without curcumin. MTT test was used for studying the effects of UVB and curcumin on the cell viability. The role of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways on the UVB-induced secretion of IL-6 and IL-8 were tested by addition of their inhibitors to the culture with or without UVB-radiation...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729863/effects-of-physiochemical-factors-on-prokaryotic-biodiversity-in-malaysian-circumneutral-hot-springs
#6
Chia S Chan, Kok-Gan Chan, Robson Ee, Kar-Wai Hong, María S Urbieta, Edgardo R Donati, Mohd S Shamsir, Kian M Goh
Malaysia has a great number of hot springs, especially along the flank of the Banjaran Titiwangsa mountain range. Biological studies of the Malaysian hot springs are rare because of the lack of comprehensive information on their microbial communities. In this study, we report a cultivation-independent census to describe microbial communities in six hot springs. The Ulu Slim (US), Sungai Klah (SK), Dusun Tua (DT), Sungai Serai (SS), Semenyih (SE), and Ayer Hangat (AH) hot springs exhibit circumneutral pH with temperatures ranging from 43°C to 90°C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28729767/glasgow-prognostic-score-after-concurrent-chemoradiotherapy-is-a-prognostic-factor-in-advanced-head-and-neck-cancer
#7
Pei-Hung Chang, Cheng-Hsu Wang, Eric Yen-Chao Chen, Shih-Wei Yang, Wen-Chi Chou, Jason Chia-Hsun Hsieh, Feng-Che Kuan, Kun-Yun Yeh
OBJECTIVE: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). METHODS: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28729632/erratum-removal-of-diethylhexyl-phthalate-from-hands-by-handwashing-evidence-from-experimental-n-of-1-and-crossover-designs
#8
Pi-I D Lin, Chia-Fang Wu, Hwang-Shang Kou, Tzu-Ying Huang, Jentaie Shiea, Ming-Tsang Wu
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729463/dietary-pufas-attenuate-nlrp3-inflammasome-activation-via-enhancing-macrophage-autophagy
#9
Lulu Shen, Yan Yang, Tiantong Ou, Chia-Chi C Key, Sarah H Tong, Russel C Sequeira, Jonathan M Nelson, Yan Nie, Zhan Wang, Elena Boudyguina, Swapnil V Shewale, Xuewei Zhu
Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how NLRP3 inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood. We fed Ldlr-/- mice diets containing 10% (calories) palm oil (PO) and 0.2% cholesterol, supplemented with an additional 10% of calories as PO, fish oil (FO), echium oil (EO, containing 18:4 n-3), or borage oil (BO, containing 18:3 n-6). Inflammasome activation, autophagic flux, and mitochondrial function were measured in peritoneal macrophages, blood monocytes, or liver from diet-fed mice...
July 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28729225/gynura-divaricata-attenuates-tumor-growth-and-tumor-relapse-after-cisplatin-therapy-in-hcc-xenograft-model-through-suppression-of-cancer-stem-cell-growth-and-wnt-%C3%AE-catenin-signalling
#10
Chia-Hung Yen, Chi-Chung Lai, Tsu-Hsiang Shia, Marcelo Chen, Hsin-Che Yu, Yu-Peng Liu, Fang-Rong Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Gynura divaricata subsp. formosana is a widely used traditional herbal medicine for treating liver disorders such as hepatitis and liver cancer in Taiwan. AIM OF THE STUDY: This study was aimed to evaluate the anti-cancer and cancer stabilization effect of water extract of the aerial part of G. divaricata (GD extract) both in vitro and in vivo. MATERIALS AND METHODS: Cytotoxicity and anti-proliferative effects of GD extract alone and in combination with cisplatin were determined by alamarBlue and clonogenic assay...
July 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28729058/impacts-of-sensation-perception-and-motor-abilities-of-the-ipsilesional-upper-limb-on-hand-functions-in-unilateral-stroke-quantifications-from-biomechanical-and-functional-perspectives
#11
Hsiu-Yun Hsu, Chia-Wen Ke, Ta-Shen Kuan, Hsiu-Ching Yang, Ching-Liang Tsai, Li-Chieh Kuo
BACKGROUND: The presence of subtle losses in hand dexterity after stroke impacts the regaining of independence with regard to activities of daily living. Therefore, awareness of ipsilesional upper extremity (UE) function may be of importance when drafting a comprehensive rehabilitation program. However, current hand function tests seem to be unable to identify asymptomatic UE impairments. OBJECTIVES: To assess the motor coordination as well as the sensory-perception of an ipsilesional UE using biomechanical analysis of performance-oriented tasks and conducting a Manual Tactile Test (MTT)...
July 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28728985/adjuvant-hepatic-arterial-infusion-chemotherapy-is-beneficial-for-selective-patients-with-hepatocellular-carcinoma-undergoing-surgical-treatment
#12
Jui-Hu Hsiao, Cheng-Chung Tsai, Tsung-Jung Liang, Chia-Ling Chiang, Huei-Lung Liang, I-Shu Chen, Yu-Chia Chen, Po-Ming Chang, Nan-Hua Chou, Being-Whey Wang
BACKGROUND: Recurrence rate after curative surgical resection of Hepatocellular carcinoma (HCC) remains high. Postoperative hepatic arterial infusion chemotherapy (HAIC) has been suggested to improve survival. This study is to investigate the efficacy of HAIC in the patients with poor tumor factors such as vascular invasion or multiplicity. METHODS: From 2006 to 2014, 221 patients with HCC undergoing hepatectomy and pathologically staged as ≧ T2 (American Joint Committee on Cancer TNM staging system, 7th edition) were included...
July 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28728750/trigeminocardiac-reflex-during-non-surgical-root-canal-treatment-of-teeth-with-irreversible-pulpitis
#13
James I-Sheng Huang, Hao-Hueng Chang, Chun-Pei Lin, Wan-Chuen Liao, Chia-Tze Kao, Tsui-Hsien Huang
BACKGROUND/PURPOSE: Trigeminocardiac reflex (TCR) is a unique clinical incident of acute change in hemodynamic balance, which may lead to hypotension, bradycardia, and even clinical crisis. Up to date, no study so far considers the impact of non-surgical root canal treatment (NSRCT) of irreversible pulpitis teeth under either local infiltration or block anesthesia on hemodynamic change possibly related to TCR. METHODS: This study enrolled 111 patients with 138 irreversible pulpitis teeth that were treated by two sessions of NSRCT...
July 17, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28728055/investigation-of-length-heteroplasmy-in-mitochondrial-dna-control-region-by-massively-parallel-sequencing
#14
Chun-Yen Lin, Li-Chin Tsai, Hsing-Mei Hsieh, Chia-Hung Huang, Yu-Jen Yu, Bill Tseng, Adrian Linacre, James Chun-I Lee
Accurate sequencing of the control region of the mitochondrial genome is notoriously difficult due to the presence of polycytosine bases, termed C-tracts. The precise number of bases that constitute a C-tract and the bases beyond the poly cytosines may not be accurately defined when analyzing Sanger sequencing data separated by capillary electrophoresis. Massively parallel sequencing has the potential to resolve such poor definition and provides the opportunity to discover variants due to length heteroplasmy...
July 10, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28727592/nutrition-exercise-and-skin-integrity-among-frail-older-adults-in-taiwan
#15
Chia-Te Chen, Heng-Hsin Tung, Tao-Hsin Tung, Jong-Chyou Denq
OBJECTIVE: The purpose was to determine the correlation between nutrition status and skin integrity in the frail older adult population. DESIGN AND SETTING: Participants (N = 94) in this cross-sectional study were recruited through convenience sampling from the neurology and geriatrics outpatient department at a regional teaching hospital in Northern Taiwan. Study tools included a Basic Participant Profile Fill-in Sheet, which assesses demographic and exercise habit; the Comorbidity Index; Skin Integrity Evaluation Chart; Mini-Nutritional Assessment-Short Form; and Taiwan International Physical Activity Questionnaire Form...
August 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28727557/integrating-flexible-sensor-and-virtual-self-organizing-dc-grid-model-with-cloud-computing-for-blood-leakage-detection-during-hemodialysis
#16
Ping-Tzan Huang, Tai-Lang Jong, Chien-Ming Li, Wei-Ling Chen, Chia-Hung Lin
Blood leakage and blood loss are serious complications during hemodialysis. From the hemodialysis survey reports, these life-threatening events occur to attract nephrology nurses and patients themselves. When the venous needle and blood line are disconnected, it takes only a few minutes for an adult patient to lose over 40% of his / her blood, which is a sufficient amount of blood loss to cause the patient to die. Therefore, we propose integrating a flexible sensor and self-organizing algorithm to design a cloud computing-based warning device for blood leakage detection...
July 18, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28726389/anti-melanogenic-effect-of-urolithin-a-and-urolithin-b-the-colonic-metabolites-of-ellagic-acid-in-b16-melanoma-cells
#17
Shang-Ta Wang, Wei-Chia Chang, Chen Hsu, Nan-Wei Su
Anti-melanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and anti-aging effects. In this study, the metabolites were found to possess depigmentation efficacy by suppressing tyrosinase activity. Both UA and UB could attenuate melanogenesis in B16 melanoma cells at non-cytotoxic doses, and UA showed comparable efficacy to positive control, kojic acid group...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28726313/selectivity-enhancements-in-gel-based-dna-nanoparticle-assays-by-membrane-induced-isotachophoresis-thermodynamics-versus-kinetics
#18
Steven Marczak, Elaine Smith, Satyajyoti Senapati, Hsueh-Chia Chang
Selectivity against mutant nontargets with a few mismatches remains challenging in nucleic acid sensing. Sensitivity enhancement by analyte concentration does not improve selectivity because it affects targets and nontargets equally. Hydrodynamic or electrical shear enhanced selectivity is often accompanied by substantial losses in target signals, thereby leading to poor limits of detection. We introduce a platform based on depletion isotachophoresis in agarose gel generated by an ion-selective membrane that allows both selectivity and sensitivity enhancement with a two-step assay involving concentration polarization at an ion-selective membrane...
July 20, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28725968/microglial-mediated-pdgf-cc-activation-increases-cerebrovascular-permeability-during-ischemic-stroke
#19
Enming Joseph Su, Chunzhang Cao, Linda Fredriksson, Ingrid Nilsson, Christina Stefanitsch, Tamara K Stevenson, Juanjuan Zhao, Margret Ragsdale, Yu-Yo Sun, Manuel Yepes, Chia-Yi Kuan, Ulf Eriksson, Dudley K Strickland, Daniel A Lawrence, Li Zhang
Treatment of acute ischemic stroke with the thrombolytic tissue plasminogen activator (tPA) can significantly improve neurological outcomes; however, thrombolytic therapy is associated with an increased risk of intra-cerebral hemorrhage (ICH). Previously, we demonstrated that during stroke tPA acting on the parenchymal side of the neurovascular unit (NVU) can increase blood-brain barrier (BBB) permeability and ICH through activation of latent platelet-derived growth factor-CC (PDGF-CC) and signaling by the PDGF receptor-α (PDGFRα)...
July 19, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28725308/a-case-with-vitamin-d-deficiency-induced-cytomegalovirus-enteritis-presenting-as-bowel-pseudo-obstruction
#20
Shou-Wu Lee, Chung-Wang Ko, Szu-Chia Liao, Chung-Shihn Chang, Hong-Zen Yeh, Chi-Sen Chang
Cytomegalovirus (CMV) infection in small intestines has rarely been reported. We report a 67-year-old woman with abdominal pain for 2 weeks. Abdominal computed tomography (CT) revealed wall-thickening of the segmental small bowel. Enteroscopy disclosed discrete ulcers at the jejunum, and biopsy histopathology showed positive CMV immunoreactivity. Laboratory tests showed positive blood CMV with a viral load of 9,400 DNA copies/mL and high IgG titer and low vitamin D level. After antiviral therapy and oral vitamin D supply, her symptoms improved...
June 2017: Gastroenterology Research
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