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https://www.readbyqxmd.com/read/28320074/diagnostic-performance-of-clinical-examination-measures-and-pain-presentation-to-identify-patellofemoral-joint-osteoarthritis
#1
J J Stefanik, R Duncan, D T Felson, G Peat
OBJECTIVE: Test the diagnostic performance of a comprehensive set of tests and measures to discriminate patellofemoral (PF) from tibiofemoral (TF) osteoarthritis (OA). METHODS: The Clinical Assessment of the Knee Study is a study of knee pain in the general population. The presence of PF crepitus and pain with PF compression were assessed. Anterior knee pain (AKP) was determined from a knee pain map. Pain with stairs and walking on level ground were assessed with the WOMAC...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28320059/effects-of-treadmill-exercise-on-advanced-osteoarthritis-pain-in-rats
#2
Joshua Allen, Ian Imbert, Joshua Havelin, Terry Henderson, Glenn Stevenson, Lucy Liaw, Tamara King
OBJECTIVE: Exercise is commonly recommended for patients with osteoarthritis (OA) pain. However, whether exercise is beneficial in ameliorating persistent NSAID-resistant ongoing pain associated with advanced OA is unknown. METHODS: Rats treated with intra-articular monosodium iodoacetate (MIA) or saline underwent treadmill exercise or remained sedentary starting 10 days post-injection. Tactile sensory thresholds and weight bearing were assessed followed by radiographs at weekly intervals...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28320058/regional-differences-between-perisynovial-and-infrapatellar-adipose-tissue-depots-and-their-response-to-class-ii-and-iii-obesity-in-patients-with-oa
#3
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, A Hamish W R Simpson
OBJECTIVE: Obesity is associated with an increased risk of developing Osteoarthritis (OA), which is postulated to be secondary to inflammation from adipose tissue (AT). There are peri-articular adipose depots in synovial joints, the association of this tissue with OA has not been extensively explored. The aim of this study was to investigate differences in local AT depots in knees with OA and changes related to class II and III obesity. METHODS: Synovium and the infrapatellar fat pad (IPFP) were collected during total knee replacement from 69 patients with end-stage OA...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28319883/the-influence-of-a-depressed-scapular-alignment-on-upper-limb-neural-tissue-mechanosensitivity-and-local-pressure-pain-sensitivity
#4
Patricia Martínez-Merinero, Enriqe Lluch, Tomas Gallezo-Izquierdo, Daniel Pecos-Martín, Gustavo Plaza-Manzano, Susana Nuñez-Nagy, Deborah Falla
BACKGROUND: A depressed scapular alignment could lead to prolonged and repetitive stress or compression of the brachial plexus, resulting in sensitization of neural tissue. However, no study has investigated the influence of alignment of the scapulae on sensitization of upper limb neural tissue in otherwise asymptomatic people. In this case-control study, we investigate the influence of a depressed scapular alignment on mechanosensitivity of the upper limb peripheral nervous system as well as pressure pain thresholds (PPT)...
March 10, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28319829/evaluation-of-the-pharmacokinetics-of-imipenem-following-regional-limb-perfusion-using-the-saphenous-and-the-cephalic-veins-in-standing-horses
#5
G Kelmer, A J Tatz, E Kdoshim, M Britzi, G Segev
This prospective experimental study goal was to determine the pharmacokinetics of imipenem after intravenous regional limb perfusion (IV-RLP) in standing horses. Nine horses participated in the study; that was approved by the University Animal Care and Use Committee. One thoracic limb or one pelvic limb of each horse was randomly selected. After the veins were catheterized, an Esmarch bandage tourniquet was applied and the catheter was injected with a solution containing 500mg of imipenem. Synovial fluid samples were collected from the fetlock joint and blood samples were collected from the jugular vein...
February 24, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28319746/predicting-biphasic-responses-in-binary-mixtures-pelargonic-acid-versus-glyphosate
#6
Regina G Belz, Hans-Peter Piepho
Predicting hormesis in mixtures is challenging, but essential considering that chemical exposures often occur in mixtures and at low doses. This study investigated mixture effects with two herbicides prone to induce hormesis and to interact, namely pelargonic acid versus glyphosate. Five independent mixture experiments were conducted in vitro to assess effects on root growth of lettuce. Mixture effects on the dose were analyzed using classical joint-action models in terms of deviation from the reference model of concentration addition...
March 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319695/suicidal-ideation-reported-on-the-phq9-and-risk-of-suicidal-behavior-across-age-groups
#7
Rebecca C Rossom, Karen J Coleman, Brian K Ahmedani, Arne Beck, Eric Johnson, Malia Oliver, Greg E Simon
OBJECTIVE: The Joint Commission recommends all patients be screened for suicide. However, differences in suicide attempt and death rates may affect how well tools predict risk across age groups. Our objective was to determine whether item 9 of the Patient Health Questionnaire (PHQ9) predicts risk for suicide attempts and deaths across age groups. METHODS: PHQ9s completed by adult outpatients treated for mental health conditions in 2010-2012 at four Mental Health Research Network-affiliated healthcare systems were used to measure depression severity and suicidal ideation...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28319502/remitting-seronegative-symmetrical-synovitis-with-pitting-edema-appearance-on-fdg-pet-ct
#8
Jianjie Wang, Chaoyu Pu, Zhenchang Wang, Jigang Yang
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare condition in the elderly and can appear as a first presentation of various types of rheumatic and malignant diseases. We presented a 62-year-old man with the diagnosis of RS3PE based on the clinical sign and laboratory data. Because of the possibility of associated malignancies in RS3PE, FDG PET/CT was performed to exclude occult tumors. The images showed multiple, symmetrically, diffusely increased F-FDG uptake in the soft tissue around joints and bones in the shoulders, hips, knees, and ankles...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319486/igg4-related-disease
#9
Emanuele Bozzalla Cassione, John H Stone
PURPOSE OF REVIEW: Remarkable insights have been gleaned recently with regard to the pathophysiology of IgG4-related disease (IgG4-RD). These findings have direct implications for the development of targeted strategies for the treatment of this condition. RECENT FINDINGS: Oligoclonal expansions of cells of both the B and T lymphocyte lineages are present in the blood of patients with IgG4-RD. Oligoclonal expansions of plasmablasts are a good biomarker for disease activity...
March 17, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28319455/joint-model-imputation-to-estimate-the-treatment-effect-on-long-term-survival-using-auxiliary-events
#10
Audrey Mauguen, Stefan Michiels, Virginie Rondeau
Clinical trial duration may be a concern in clinical research, especially in cancer trials where the endpoint is overall survival. A surrogate endpoint can be used as an auxiliary variable to analyze the treatment effect earlier. At an early time point, the high number of censored observations can be compensated by the imputation of the unobserved deaths times. We propose to use predictions of the risk of death from a joint model for a recurrent event and a terminal event, which account for disease relapse information...
February 16, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28319426/high-satisfaction-and-return-to-sports-after-total-shoulder-arthroplasty-in-patients-aged-55-years-and-younger
#11
Grant H Garcia, Joseph N Liu, Alec Sinatro, Hao-Hua Wu, Joshua S Dines, Russell F Warren, David M Dines, Lawrence V Gulotta
BACKGROUND: Young, active candidates for total shoulder arthroplasty (TSA) are a unique group of patients. Not only do they demand longevity and improved function, but they also desire a return to physical activities. PURPOSE: To determine the rate of return to sports in patients aged ≤55 years undergoing TSA. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This was a retrospective review of consecutive patients who underwent anatomic TSA at a single institution...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28319296/joint-effects-of-climate-variability-and-socio-ecological-factors-on-dengue-transmission-epidemiological-evidence
#12
REVIEW
Rokeya Akter, Wenbiao Hu, Suchithra Naish, Shahera Banu, Shilu Tong
OBJECTIVE: To assess the epidemiological evidence on the joint effects of climate variability and socio-ecological factors on dengue transmission. METHODS: Following PRISMA guidelines, a detailed literature search was conducted in PubMed, Web of Science and Scopus. Peer-reviewed, freely available and full text articles, considering both climate and socio-ecological factors in relation to dengue, published in English from January 1993 to October 2015 were included in this review...
March 20, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28319276/comparisons-of-statistical-techniques-to-assess-age-related-skeletal-markers-in-bioarchaeology
#13
Colleen M Cheverko, Mark Hubbe
OBJECTIVES: Many authors argue that inconsistencies between studies of skeletal markers are based on different data collection protocols, especially when comparing age-related markers such as osteoarthritis. Less attention is given to the choice of statistical techniques that are used to test the hypotheses associated with the data. This paper addresses how different statistical techniques compare the prevalence of age-related skeletal indicators, specifically osteoarthritis. MATERIALS AND METHODS: Osteoarthritis prevalence was scored in eight postcranial joints in 243 adult individuals from seven prehistoric archaeological sites in Central California, and data was compared between three time periods [Early (4800-2800 BP), Middle (2800-1200 BP), and Late (1200-250 BP)] using commonly used statistical tests: chi-square, Fisher's exact, and odds ratios...
March 20, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28319229/patient-mortality-during-unannounced-accreditation-surveys-at-us-hospitals
#14
Michael L Barnett, Andrew R Olenski, Anupam B Jena
Importance: In the United States, hospitals receive accreditation through unannounced on-site inspections (ie, surveys) by The Joint Commission (TJC), which are high-pressure periods to demonstrate compliance with best practices. No research has addressed whether the potential changes in behavior and heightened vigilance during a TJC survey are associated with changes in patient outcomes. Objective: To assess whether heightened vigilance during survey weeks is associated with improved patient outcomes compared with nonsurvey weeks, particularly in major teaching hospitals...
March 20, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28319197/the-hiv-care-cascade-japanese-perspectives
#15
Aikichi Iwamoto, Rikizo Taira, Yoshiyuki Yokomaku, Tomohiko Koibuchi, Mahbubur Rahman, Yoko Izumi, Kenji Tadokoro
Japan has been known as a low HIV-prevalence country with a concentrated epidemic among high-risk groups. However, it has not been determined whether Japan meets the 90-90-90 goals set by the Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO). Moreover, to date, the HIV care cascade has not been examined. We estimated the total number of diagnosed people living with HIV/AIDS (PLWHA) (n = 22,840) based on legal reports to the Ministry of Health, Labour and Welfare by subtracting the number of foreigners who left Japan (n = 2,273) and deaths (n = 2,321) from the cumulative diagnosis report (n = 27,434)...
2017: PloS One
https://www.readbyqxmd.com/read/28319145/does-aquatic-exercise-reduce-hip-and-knee-joint-loading-in-vivo-load-measurements-with-instrumented-implants
#16
Ines Kutzner, Anja Richter, Katharina Gordt, Jörn Dymke, Philipp Damm, Georg N Duda, Reiner Günzl, Georg Bergmann
Aquatic exercises are widely used for rehabilitation or preventive therapies in order to enable mobilization and muscle strengthening while minimizing joint loading of the lower limb. The load reducing effect of water due to buoyancy is a main advantage compared to exercises on land. However, also drag forces have to be considered that act opposite to the relative motion of the body segments and require higher muscle activity. Due to these opposing effects on joint loading, the load-reducing effect during aquatic exercises remains unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28319014/human-biomonitoring-science-and-policy-for-a-healthy-future-april-17-19-2016-berlin-germany
#17
Joas Anke, Gerda Schwedler, Judy Choi, Marike Kolossa-Gehring
Following the success of the 1st International Conference on Human Biomonitoring (HBM) in Berlin in 2010, the 2nd International Conference on Human Biomonitoring took place in Berlin from April 17-19, 2016 for an exchange and updates among participants on all aspects relating to HBM. Entitled "Science and Policy for a Healthy Future", the conference brought together international experts from the scientific sector, politics, authorities, industry, non-governmental organizations (NGOs), and other involved associations...
February 7, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28318925/retrospective-evaluation-of-three-different-joint-surgeries-for-internal-derangements-of-the-temporomandibular-joint
#18
Celal Candirli, Mehmet Demirkol, Onur Yilmaz, Sadi Memis
PURPOSE: To compare the outcomes achieved with eminectomy, discectomy alone, and discectomy with an abdominal dermis fat graft (D + ADFG) in the treatment of internal derangements (IDs) of the temporomandibular joint (TMJ), and to briefly discuss the failed cases in which a second operation was needed. PATIENTS AND METHODS: This was a retrospective study of 31 patients (27 females, 4 males) who were unresponsive to conservative therapy and therefore underwent eminectomy (group A, n = 6), discectomy alone (group B, n = 8), or D + ADFG (group C, n = 17)...
February 13, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28318915/computer-assisted-positioning-of-the-proximal-segment-after-sagittal-split-osteotomy-of-the-mandible-preclinical-investigation-of-a-novel-electromagnetic-navigation-system
#19
Igor Nova, Sebastian Kallus, Moritz Berger, Oliver Ristow, Urs Eisenmann, Christian Freudlsperger, Jürgen Hoffmann, Hartmut Dickhaus
INTRODUCTION: Modifications of the temporomandibular joint position after mandible osteotomy are reluctantly accepted in orthognathic surgery. To tackle this problem, we developed a new navigation system using miniaturized electromagnetic sensors. Our imageless navigation approach is therefore optimized to avoid complications of previously proposed optical approaches such as the interference with established surgical procedures and the line of sight problem. MATERIAL AND METHODS: High oblique sagittal split osteotomies were performed on 6 plastic skull mandibles in a laboratory under conditions comparable to the operating theatre...
February 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28318869/registry-data-valuable-lessons-but-beware-the-confounders
#20
John G Stammers, Alex Kuo, Alister J Hart, Liam Smeeth, John A Skinner
A mature national joint registry with widespread adoption and audit can successfully demonstrate trends and influence future orthopedic practice. Correlations can be identified; however, this should not be misinterpreted as causality. It is essential to consider confounding when analyzing observational datasets.
February 17, 2017: Journal of Arthroplasty
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