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https://www.readbyqxmd.com/read/29161604/ecological-effects-and-potential-risks-of-the-water-diversion-project-in-the-heihe-river-basin
#1
Mengmeng Zhang, Shuai Wang, Bojie Fu, Guangyao Gao, Qin Shen
To curb the severe ecological deterioration in the lower Heihe River Basin (HRB) in northwest China, a water diversion project was initiated in 2000. A comprehensive analysis of the ecological effects and potential risks associated with the project is needed. We assessed the hydrological and ecological achievements, and also analyzed the potential problems after the project was completed. We found that since the project began the hydrological regime has changed, with more than 57.82% of the upstream water being discharged to the lower reaches on average...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161469/validation-of-a-definition-for-flare-in-patients-with-established-gout
#2
Angelo L Gaffo, Nicola Dalbeth, Kenneth G Saag, Jasvinder A Singh, Elizabeth J Rahn, Amy S Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana Beatriz Vargas-Santos, Geraldo da Rocha Castelar-Pinheiro, Rodrigo B C Amorim, Till Uhlig, Hilde B Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M McCarthy, Lisa K Stamp, Martijn Gerritsen, Viktoria Fana, Francisca Sivera, William Taylor
OBJECTIVE: To perform external validation of provisional gout flare (attack) definitions in patients with gout. METHODS: We enrolled 509 participants with gout from 17 international sites in a cross-sectional study performed during routine clinical care and collected data to classify participants as experiencing a gout flare or not according to a provisional definition. A local expert rheumatologist performed the final independent adjudication of the gout flare status...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161460/wnt-signaling-related-to-subchondral-bone-density-and-cartilage-degradation-in-oa
#3
EDITORIAL
David B Burr, Achint Utreja
The role of subchondral bone in the progression of osteoarthritis has been controversial for nearly 50 years.((1,2)) The observation that subchondral sclerosis was nearly always present in end-stage disease led to the conclusion that the increased stiffness caused by a thicker subchondral bone plate detracted from the bone's ability to attenuate the loads imposed on the joint cartilage, increasing cartilage stresses and initiating the process of joint deterioration. Because cartilage damage does not always progress to full thickness cartilage loss and OA, Radin and Rose((3)) proposed that the initiation and the progression of cartilage deterioration were separate processes...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161448/prenatal-famine-exposure-adulthood-obesity-patterns-and-risk-of-type-2-diabetes
#4
Ruogu Meng, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hui Zhang, Xiaofang Chen, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Background: Prenatal exposure to famine and adulthood obesity have been independently related to the risk of type 2 diabetes; however, little is known about the joint effects of these risk factors at different stages of life on adulthood diabetes risk. Methods: The analysis included 88 830 participants of the China Kadoorie Biobank, who were born around the time of the Chinese Great Famine and without diabetes, cardiovascular diseases, or cancer at baseline. We defined famine exposure subgroups as nonexposed (born between 1 October 1962 and 30 September 964), fetal-exposed (born between 1 October 1959 and 30 September 1961) and early-childhood exposed (born between 1 October 1956 and 30 September 1958)...
November 17, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29161273/enrichment-of-colorectal-cancer-associations-in-functional-regions-insight-for-using-epigenomics-data-in-the-analysis-of-whole-genome-sequence-imputed-gwas-data
#5
Stephanie A Bien, Paul L Auer, Tabitha A Harrison, Conghui Qu, Charles M Connolly, Peyton G Greenside, Sai Chen, Sonja I Berndt, Stéphane Bézieau, Hyun M Kang, Jeroen Huyghe, Hermann Brenner, Graham Casey, Andrew T Chan, John L Hopper, Barbara L Banbury, Jenny Chang-Claude, Stephen J Chanock, Robert W Haile, Michael Hoffmeister, Christian Fuchsberger, Mark A Jenkins, Suzanne M Leal, Mathieu Lemire, Polly A Newcomb, Steven Gallinger, John D Potter, Robert E Schoen, Martha L Slattery, Joshua D Smith, Loic Le Marchand, Emily White, Brent W Zanke, Goncalo R Abeçasis, Christopher S Carlson, Ulrike Peters, Deborah A Nickerson, Anshul Kundaje, Li Hsu
BACKGROUND: The evaluation of less frequent genetic variants and their effect on complex disease pose new challenges for genomic research. To investigate whether epigenetic data can be used to inform aggregate rare-variant association methods (RVAM), we assessed whether variants more significantly associated with colorectal cancer (CRC) were preferentially located in non-coding regulatory regions, and whether enrichment was specific to colorectal tissues. METHODS: Active regulatory elements (ARE) were mapped using data from 127 tissues and cell-types from NIH Roadmap Epigenomics and Encyclopedia of DNA Elements (ENCODE) projects...
2017: PloS One
https://www.readbyqxmd.com/read/29161264/proprioceptive-assessment-in-clinical-settings-evaluation-of-joint-position-sense-in-upper-limb-post-stroke-using-a-robotic-manipulator
#6
Sara Contu, Asif Hussain, Simone Kager, Aamani Budhota, Vishwanath A Deshmukh, Christopher W K Kuah, Lester H L Yam, Liming Xiang, Karen S G Chua, Lorenzo Masia, Domenico Campolo
Proprioception is a critical component for motor functions and directly affects motor learning after neurological injuries. Conventional methods for its assessment are generally ordinal in nature and hence lack sensitivity. Robotic devices designed to promote sensorimotor learning can potentially provide quantitative precise, accurate, and reliable assessments of sensory impairments. In this paper, we investigate the clinical applicability and validity of using a planar 2 degrees of freedom robot to quantitatively assess proprioceptive deficits in post-stroke participants...
2017: PloS One
https://www.readbyqxmd.com/read/29161226/development-of-competitive-enzyme-linked-immunosorbent-assays-for-antibody-detection-based-on-bluetongue-virus-monoclonal-antibodies
#7
Zhou Han, Zang Mingxin, Li Xuechun, Xu Yigang, Qiao Xinyuan, Wang Li, Cui Wen, Jiang Yanping, Li Yijing, Tang Lijie
Bluetongue is a ruminant infectious disease that is characterized by hyperpyrexia, leukocyte decrease and mucosal ulcerative inflammation changes. In this study, three segments of Bluetongue virus (BTV)-8 VP2 protein (BTV-8A, 8B, and 8C) were cloned into pET-28a (+) and pMAl-c5X vectors and expressed in Escherichia coli BL21 (DE3) as histidine (His)-tagged (His-8A/8B/8C) and maltose-binding protein (MBP)-tagged (MBP-8A/8B/8C) fusion proteins. After purification, His-8A/8B/8C were used to immunize BALB/mice and MBP-8A/8B/8C were used to screen for monoclonal antibody (mAb)-secreting hybridomas...
November 21, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29161218/the-impact-of-dementia-on-relationships-intimacy-and-sexuality-in-later-life-couples-an-integrative-qualitative-analysis-of-existing-literature
#8
Kristen Holdsworth, Marita McCabe
OBJECTIVES: The onset and progression of dementia can have a profound effect on the couple dyad. The aim of this systematic review was to analyze the literature investigating the impact of dementia on the relationships, intimacy, and sexuality in older couples. METHODS: A systematic literature search was conducted in May 2016 for relevant research articles. Five databases were searched: Web of Science, PsycINFO, MedLine, Scopus and CINAHL. The reference lists of articles included in the review were screened along with the reference list of other relevant reviews...
September 15, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29161205/imbalance-between-clinical-and-pathologic-staging-in-the-updated-american-joint-commission-cancer-staging-system-for-human-papillomavirus-positive-oropharyngeal-cancer
#9
Carole Fakhry, Jose P Zevallos, David W Eisele
No abstract text is available yet for this article.
November 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29161138/autologous-matrix-induced-chondrogenesis-a-systematic-review-of-the-clinical-evidence
#10
Liang Gao, Patrick Orth, Magali Cucchiarini, Henning Madry
BACKGROUND: The addition of a type I/III collagen membrane in cartilage defects treated with microfracture has been advocated for cartilage repair, termed "autologous matrix-induced chondrogenesis" (AMIC). PURPOSE: To examine the current clinical evidence regarding AMIC for focal chondral defects. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29161115/hip-arthroscopic-surgery-for-femoroacetabular-impingement-with-capsular-management-factors-associated-with-achieving-clinically-significant-outcomes
#11
Gregory L Cvetanovich, Alexander E Weber, Benjamin D Kuhns, Jennifer Alter, Joshua D Harris, Richard C Mather, Shane J Nho
BACKGROUND: There has been increasing interest in defining clinically meaningful outcomes in patient reported outcomes following orthopaedic surgery. Little is known about the factors associated with clinically meaningful outcomes after hip arthroscopy for femoroacetabular impingement. STUDY DESIGN: Case-control study; Level of evidence, 3. PURPOSE: To report on a large, prospectively collected consecutive series of patients who underwent comprehensive arthroscopic treatment of femoroacetabular impingement (FAI) and capsular management with greater than 2-year follow-up...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29161096/the-role-of-healthcare-technology-management-in-facilitating-medical-device-cybersecurity
#12
Mike Busdicker, Priyanka Upendra
This article discusses the role of healthcare technology management (HTM) in medical device cybersecurity and outlines concepts that are applicable to HTM professionals at a healthcare delivery organization or at an integrated delivery network, regardless of size. It provides direction for HTM professionals who are unfamiliar with the security aspects of managing healthcare technologies but are familiar with standards from The Joint Commission (TJC). It provides a useful set of recommendations, including relevant references for incorporating good security practices into HTM practice...
September 2, 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29161020/deformation-drives-alignment-of-nanofibers-in-framework-for-inducing-anisotropic-cellulose-hydrogels-with-high-toughness
#13
Dongdong Ye, Qiaoyun Cheng, Qianlei Zhang, Yixiang Wang, Chunyu Chang, Liangbin Li, Haiyan Peng, Lina Zhang
Deformation driven alignment of molecules or nanofibers leading to anisotropy is a challenge in functional soft materials. Here, high toughness hydrogels with deformation-induced anisotropy are fabricated from cellulose solution in LiOH/urea, relying on successively designing a loose chemical crosslinking network and a dense physical network containing nanofibers and submicrobundles formed through parallel self-aggregation in dilute acid. The loose network acts as a large framework, whereas relatively dense physical networks are integrated inside, jointly constituting the hierarchical architecture...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160897/social-integration-and-survival-after-diagnosis-of-colorectal-cancer
#14
Elizabeth A Sarma, Ichiro Kawachi, Elizabeth M Poole, Shelley S Tworoger, Edward L Giovannucci, Charles S Fuchs, Ying Bao
BACKGROUND: Although larger social networks have been associated with lower all-cause mortality, few studies have examined whether social integration predicts survival outcomes among patients with colorectal cancer (CRC). The authors examined the association between social ties and survival after CRC diagnosis in a prospective cohort study. METHODS: Participants included 896 women in the Nurses' Health Study who were diagnosed with stage I, II, or III CRC between 1992 and 2012...
November 21, 2017: Cancer
https://www.readbyqxmd.com/read/29160819/physical-fighting-and-associated-factors-among-adolescents-aged-13-15-years-in-six-western-pacific-countries
#15
Lili Yang, Yuanyuan Zhang, Bo Xi, Pascal Bovet
Youth violence is an important public health challenge around the world, yet the literature on this problem in low- and middle-income countries (LMICs) has been limited. The present study aims to examine the prevalence of adolescent physical fighting (defined as having been involved in at least one physical fight during the past 12 months) in selected LMICs, and its relations with potential risk factors. We included 6377 school-going adolescents aged 13-15 years from six Western Pacific (WP) countries that had recently conducted a Global School-based Student Health Survey...
November 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29160796/role-of-galectin-3-in-bone-cell-differentiation-bone-pathophysiology-and-vascular-osteogenesis
#16
REVIEW
Carla Iacobini, Claudia Blasetti Fantauzzi, Giuseppe Pugliese, Stefano Menini
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate cartilage, where it favors chondrocyte survival and cartilage matrix mineralization. It was also shown to be highly expressed in differentiating osteoblasts and osteoclasts, in concomitance with expression of osteogenic markers and Runt-related transcription factor 2 and with the appearance of a mature phenotype...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160644/how-to-manage-joint-pain-in-children-and-adolescents
#17
Edoardo Marrani, Ilaria Maccora, Teresa Giani, Gabriele Simonini, Rolando Cimaz
In children, joint pain is common complaint and it proves challenging for primary care physicians. The differential possible diagnoses include a wide range of disorders, from the common and benign ones to serious and even lifethreating conditions. An accurate workup of these patients is needed, with thorough patient history and a systematic physical examination as essential tools. Clarifying the nature, the site, and the duration of the pain is fundamental as well as identifying systemic symptoms such as fever, weight loss, and night sweating...
November 21, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/29160630/synthetic-grafts-in-the-treatment-of-ruptured-anterior-cruciate-ligament-of-the-knee-joint
#18
REVIEW
Wojciech Satora, Aleksandra Królikowska, Andrzej Czamara, Paweł Reichert
The anterior cruciate ligament (ACL) is cited as the most frequently injured ligament in the knee. The standard treatment of ACL injury remains ligament reconstruction followed by a postoperative physiotherapeutic procedure. During the reconstruction, the torn ligament can be replaced with an autograft or an allograft. A synthetic ligament is also one of the available graft options. Synthetic grafts in ruptured ACL treatment have been used as scaffolds, stents, or prostheses. The story of using synthetic materials in ACL deficient knee treatment started in the beginning of the 20th century with the usage of silk and silver fibers...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160503/alert-severe-cases-and-deaths-associated-with-chikungunya-in-brazil
#19
Carlos Alexandre Antunes de Brito
Since the detection of the Chikungunya virus in America in 2013, two million cases of the disease have been notified worldwide. Severe cases and deaths related to Chikungunya have been reported in India and Reunion Island, estimated at 1 death per 1,000 inhabitants. Joint involvement in the acute and chronic phase is the main clinical manifestation associated with Chikungunya. The severity of the infection may be directly attributable to viral action or indirectly, owing to decompensation of preexisting comorbidities...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160494/managing-febrile-neutropenia-in-adult-cancer-patients-an-integrative-review-of-the-literature
#20
Juliana Nunes Ferreira, Lury Renata Barbosa Ribeiro Correia, Renata Moreira de Oliveira, Silvia Naomi Watanabe, João Francisco Possari, Antônio Fernandes Costa Lima
OBJECTIVE: To analyze the interventions performed by health professionals with a view to managing chemotherapy-induced febrile neutropenia. METHOD: Integrative literature review, the sample of 12 primary articles was selected from the following databases: LILACS, SciELO, BVS, PubMed, CINAHL and Web of Science. RESULTS: There was a prevalence of studies, realized by doctors, focused on pharmacological treatment and on the association of methods for greater diagnostic accuracy of febrile neutropenia...
November 2017: Revista Brasileira de Enfermagem
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