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https://www.readbyqxmd.com/read/28922669/a-critical-commentary-on-the-2017-agnp-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology
#1
Jose de Leon
In 2004, 2011, and 2017, the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP), a group of German-speaking psychiatric researchers and psychiatrists, published successive versions of therapeutic drug monitoring (TDM) expert group consensus guidelines. The 2017 version has as a major strength its encyclopedic nature, including 1358 references. The guideline has 3 major sections: 1) theoretical aspects of TDM, 2) drug concentration levels in blood to guide neuropsychopharmacotherapy, and 3) practical aspects of TDM in psychiatry and neurology...
September 18, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28922133/aligning-event-logs-to-task-time-matrix-clinical-pathways-in-bpmn-for-variance-analysis
#2
Hui Yan, Pieter Van Gorp, Uzay Kaymak, Xudong Lu, Lei Ji, Choo Chiap Chiau, Hendriks H M Korsten, Huilong Duan
Clinical pathways (CPs) are popular healthcare management tools to standardise care and ensure quality. Analysing CP compliance levels and variances is known to be useful for training and CP redesign purposes. Flexible semantics of the Business Process Model and Notation (BPMN) language has been shown to be useful for the modeling and analysis of complex protocols. However, in practical cases one may want to exploit that CPs often have the form of Task-Time matrices. This paper presents a new method parsing complex BPMN models and aligning traces to the models heuristically...
September 18, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28916009/incorporating-trainees-development-into-a-multidisciplinary-training-model-for-integrated-behavioral-health-within-a-pediatric-continuity-clinic
#3
REVIEW
Kimberly Kelsay, Maya Bunik, Melissa Buchholz, Bridget Burnett, Ayelet Talmi
Integrated behavioral and mental health systems of care for children require multidisciplinary team members to have specific competencies and knowledge of the other disciplines' strengths and practice needs. Training models for multidisciplinary professionals should consider the developmental level of trainees. The authors describe a model of flexible scaffolding, increasing intensity, and depth of experience as trainees gain skills and knowledge.
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28915856/exercise-prescription-for-patients-with-multiple-sclerosis-potential-benefits-and-practical-recommendations
#4
Farzin Halabchi, Zahra Alizadeh, Mohammad Ali Sahraian, Maryam Abolhasani
BACKGROUND: Multiple sclerosis (MS) can result in significant mental and physical symptoms, specially muscle weakness, abnormal walking mechanics, balance problems, spasticity, fatigue, cognitive impairment and depression. Patients with MS frequently decrease physical activity due to the fear from worsening the symptoms and this can result in reconditioning. Physicians now believe that regular exercise training is a potential solution for limiting the reconditioning process and achieving an optimal level of patient activities, functions and many physical and mental symptoms without any concern about triggering the onset or exacerbation of disease symptoms or relapse...
September 16, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28910762/deep-edge-guided-recurrent-residual-learning-for-image-super-resolution
#5
Wenhan Yang, Jiashi Feng, Jianchao Yang, Fang Zhao, Jiaying Liu, Zongming Guo, Shuicheng Yan
In this work, we consider the image super-resolution (SR) problem. The main challenge of image SR is to recover high-frequency details of a low-resolution (LR) image that are important for human perception. To address this essentially illposed problem, we introduce a Deep Edge Guided REcurrent rEsidual (DEGREE) network to progressively recover the highfrequency details. Different from most of existing methods that aim at predicting high-resolution (HR) images directly, DEGREE investigates an alternative route to recover the difference between a pair of LR and HR images by recurrent residual learning...
September 8, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28903976/working-hard-but-working-differently-a-qualitative-study-of-the-impact-of-generational-change-on-rural-health-care
#6
David Snadden, Mark Alexander Kunzli
BACKGROUND: There is limited literature evaluating generational change in the physician workforce and the adjustments required of practices, practitioners and the health care system as a whole. The purpose of this study was to explore rural practitioners' experiences of their current contexts relevant to recruitment and retention and to determine how practices are responding to changing aspirations of new practitioners. METHODS: We used qualitative methods. Participants were selected to ensure diversity of career stage...
September 12, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28899418/the-effect-of-a-national-web-course-help-brain-heart-as-a-supplemental-learning-tool-before-cpr-training-a-cluster-randomised-trial
#7
Anette Nord, Leif Svensson, Andreas Claesson, Johan Herlitz, Håkan Hult, Susanne Kreitz-Sandberg, Lennart Nilsson
BACKGROUND: The effectiveness of cardiopulmonary resuscitation (CPR) learning methods is unclear. Our aim was to evaluate whether a web course before CPR training, teaching the importance of recognition of symptoms of stroke and acute myocardial infarction (AMI) and a healthy lifestyle, could influence not only theoretical knowledge but also practical CPR skills or willingness to act in a cardiac arrest situation. METHODS: Classes with 13-year-old students were randomised to CPR training only (control) or a web course plus CPR training (intervention)...
September 12, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28899341/development-of-a-home-based-training-program-for-post-ward-geriatric-rehabilitation-patients-with-cognitive-impairment-study-protocol-of-a-randomized-controlled-trail
#8
Martin Bongartz, Rainer Kiss, Phoebe Ullrich, Tobias Eckert, Jürgen Bauer, Klaus Hauer
BACKGROUND: Geriatric patients with cognitive impairment (CI) show an increased risk for a negative rehabilitation outcome and reduced functional recovery following inpatient rehabilitation. Despite this obvious demand, evidence-based training programs at the transition from rehabilitation to the home environments are lacking. The aim of this study is to evaluate the efficacy of a feasible and cost-effective home-based training program to improve motor performance and to promote physical activity, specifically-tailored for post-ward geriatric patients with CI...
September 12, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28895236/protein-surface-roughness-accounts-for-binding-free-energy-of-plasmepsin-ii-ligand-complexes
#9
Mario E Valdés-Tresanco, Mario S Valdés-Tresanco, Pedro A Valiente, Germinal Cocho, Ricardo Mansilla, J M Nieto-Villar
The calculation of absolute binding affinities for protein-inhibitor complexes remains as one of the main challenges in computational structure-based ligand design. The present work explored the calculations of surface fractal dimension (as a measure of surface roughness) and the relationship with experimental binding free energies of Plasmepsin II complexes. Plasmepsin II is an attractive target for novel therapeutic compounds to treat malaria. However, the structural flexibility of this enzyme is a drawback when searching for specific inhibitors...
September 12, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28893767/gps-perceptions-of-resilience-training-a-qualitative-study
#10
Anna Cheshire, John Hughes, George Lewith, Maria Panagioti, David Peters, Chantal Simon, Damien Ridge
BACKGROUND: GPs are reporting increasing levels of burnout, stress, and job dissatisfaction, and there is a looming GP shortage. Promoting resilience is a key strategy for enhancing the sustainability of the healthcare workforce and improving patient care. AIM: To explore GPs' perspectives on the content, context, and acceptability of resilience training programmes in general practice, in order to build more effective GP resilience programmes. DESIGN AND SETTING: This was a qualitative study of the perspectives of GPs currently practising in England...
September 11, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28892437/public-health-system-research-in-public-health-emergency-preparedness-in-the-united-states-2009-2015-actionable-knowledge-base
#11
Elena Savoia, Leesa Lin, Dottie Bernard, Noah Klein, Lyndon P James, Stefano Guicciardi
BACKGROUND: In 2008, the Institute of Medicine released a letter report identifying 4 research priority areas for public health emergency preparedness in public health system research: (1) enhancing the usefulness of training, (2) improving timely emergency communications, (3) creating and maintaining sustainable response systems, and (4) generating effectiveness criteria and metrics. OBJECTIVES: To (1) identify and characterize public health system research in public health emergency preparedness produced in the United States from 2009 to 2015, (2) synthesize research findings and assess the level of confidence in these findings, and (3) describe the evolution of knowledge production in public health emergency preparedness system research...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28892143/rodent-test-of-attention-and-impulsivity-the-5-choice-serial-reaction-time-task
#12
Guy A Higgins, Leo B Silenieks
The 5-choice serial reaction time task (5-CSRTT) is employed extensively to measure attention in rodents. The assay involves animals trained to respond to a brief, unpredictable visual stimulus presented in one of five locations. The effects of experimental manipulations on response speed and choice accuracy are measured, and each related to attentional performance. The 5-CSRTT is also used to measure motor impulsivity. Adapted from a human task, the 5-CSRTT can be employed with rodents or primates, highlighting its translational value...
September 11, 2017: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/28888434/ensuring-food-safety-in-food-donations-case-study-of-the-belgian-donation-acceptation-chain
#13
E De Boeck, L Jacxsens, H Goubert, M Uyttendaele
The food donation process in Belgium is mapped and analyzed to identify bottlenecks in compliance with the legal framework and implementation of food safety management, based on literature search and interviews with stakeholders (donors, acceptors, regulators and facilitators) in Belgium and at EU level. The study revealed that the food donation/acceptation chain is far less structured and organized than the conventional food supply chain. The fragmented landscape of many small food banks and charity organizations (acceptors), often directed by and working with volunteers without training in food safety and lack of knowledge of legal food hygiene requirements is a bottleneck to generate trust among food donors and restricts the provision of perishable products in food donations...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28887857/development-of-a-patient-specific-atrial-phantom-model-for-planning-and-training-of-inter-atrial-interventions
#14
Pedro Morais, João Manuel R S Tavares, Sandro Queirós, Fernando Veloso, Jan D'hooge, João L Vilaça
BACKGROUND: Several authors have presented cardiac phantoms to mimic the particularities of the heart, making it suitable for medical training and surgical planning. Although the initial models were mainly focused on the ventricles, personalized phantoms of the atria were recently presented. However, such models are typically rigid, the atrial wall is not realistic and they are not compatible with ultrasound, being sub-optimal for planning/training of several interventions. METHODS: In this work, we propose a strategy to construct a patient-specific atrial model...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28885479/high-dose-subcutaneous-immunoglobulin-in-patients-with-multifocal-motor-neuropathy-a-nursing-perspective
#15
Vilija M Rasutis, Hans D Katzberg, Vera Bril
Multifocal motor neuropathy (MMN), an immune neuromuscular condition causing progressive weakness, usually responds to immune-mediated treatments, including intravenous immunoglobulin (IVIG). Fifteen patients with MMN receiving IVIG were enrolled in an open-label, single-center trial and switched to 20% subcutaneous immunoglobulin (SCIG) using a smooth transition protocol (ie, changing the therapy without interruption or impact on the intended outcome of the therapy). Patients received individualized training and support based on motivation and ability to learn, follow directions, and maintain compliance...
September 2017: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/28885424/creating-flexible-and-sustainable-work-models-for-academic-obstetrician-gynecologists-engaged-in-global-health-work
#16
Rose Molina, Adeline Boatin, Huma Farid, Rebecca Luckett, Dayna Neo, Hope Ricciotti, Jennifer Scott
OBJECTIVE: To describe various work models for obstetrics and gynecology global health faculty affiliated with academic medical centers and to identify barriers and opportunities for pursuing global health work. METHODS: A mixed-methods study was conducted in 2016 among obstetrics and gynecology faculty and leaders from seven academic medical institutions in Boston, Massachusetts. Global health faculty members were invited to complete an online survey about their work models and to participate in semistructured interviews about barriers and facilitators of these models...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28876987/a-novel-approach-to-simulation-based-education-for-veterinary-medical-communication-training-over-eight-consecutive-pre-clinical-quarters
#17
Ryane E Englar
Experiential learning through the use of standardized patients (SPs) is the primary way by which human medical schools teach clinical communication. The profession of veterinary medicine has followed suit in response to new graduates' and their employers' concerns that veterinary interpersonal skills are weak and unsatisfactory. As a result, standardized clients (SCs) are increasingly relied upon as invaluable teaching tools within veterinary curricula to advance relationship-centered care in the context of a clinical scenario...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28868892/home-based-pulmonary-rehabilitation-for-people-with-copd-a-qualitative-study-reporting-the-patient-perspective
#18
Aroub Lahham, Christine F McDonald, Ajay Mahal, Annemarie L Lee, Catherine J Hill, Angela T Burge, Narelle S Cox, Rosemary Moore, Caroline Nicolson, Paul O'Halloran, Rebecca Gillies, Anne E Holland
This study aimed to document the perspective of patients with chronic obstructive pulmonary disease (COPD) who underwent home-based pulmonary rehabilitation (HBPR) in a clinical trial. In this qualitative study, open-ended questions explored participants' views regarding HBPR. Thirteen semi-structured interviews were analysed using a thematic analysis approach. Major themes from interviews included the positive impact of HBPR on physical fitness, breathing and mood. Participants valued the flexibility and convenience of the programme...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28862046/glucose-metabolism-and-metabolic-flexibility-in-cultured-skeletal-muscle-cells-is-related-to-exercise-status-in-young-male-subjects
#19
Jenny Lund, Daniel S Tangen, Håvard Wiig, Hans K Stadheim, Siw A Helle, Jesper B Birk, Thorsten Ingemann-Hansen, Arild C Rustan, G Hege Thoresen, Jørgen F P Wojtaszewski, Eili T Kase, Jørgen Jensen
We hypothesised that skeletal muscles of healthy young people have a large variation in oxidative capacity and fibre-type composition, and aimed therefore to investigate glucose metabolism in biopsies and myotubes isolated from musculus vastus lateralis from healthy males with varying degrees of maximal oxygen uptake. Trained and intermediary trained subjects showed higher carbohydrate oxidation in vivo. Fibre-type distribution in biopsies and myotubes did not differ between groups. There was no correlation between fibre-type I expression in biopsies and myotubes...
September 1, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28860986/classification-of-movement-and-inhibition-using-a-hybrid-bci
#20
Jennifer Chmura, Joshua Rosing, Steven Collazos, Shikha J Goodwin
Brain-computer interfaces (BCIs) are an emerging technology that are capable of turning brain electrical activity into commands for an external device. Motor imagery (MI)-when a person imagines a motion without executing it-is widely employed in BCI devices for motor control because of the endogenous origin of its neural control mechanisms, and the similarity in brain activation to actual movements. Challenges with translating a MI-BCI into a practical device used outside laboratories include the extensive training required, often due to poor user engagement and visual feedback response delays; poor user flexibility/freedom to time the execution/inhibition of their movements, and to control the movement type (right arm vs...
2017: Frontiers in Neurorobotics
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