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https://www.readbyqxmd.com/read/29331050/exercise-counteracts-lipotoxicity-by-improving-lipid-turnover-and-lipid-droplet-quality
#1
Evelyn Zacharewicz, Matthijs K C Hesselink, Patrick Schrauwen
The incidence of obesity and metabolic disease, such as type 2 diabetes mellitus (T2D), are rising globally. Dietary lipid over-supply leads to lipid accumulation at ectopic sites, such as skeletal muscle. Ectopic lipid storage is highly correlated with insulin resistance and T2D, likely due to a loss of metabolic flexibility - the capacity to switch between fat and glucose oxidation upon insulin stimulation - and cellular dysfunction because of lipotoxicity. However, muscle lipid levels are also elevated in endurance trained athletes, presenting a paradoxical phenotype of increased intramuscular lipids along with high insulin sensitivity - the "athletes' paradox"...
January 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29328993/activity-based-classification-circumvents-affinity-prediction-problems-for-pyrrolidine-carboxamide-inhibitors-of-inha
#2
Yogesh Narkhede, Benjamin Merget, Steffen Wagner, Christoph Sotriffer
Developing reliable structure-based activity prediction models for a particular ligand series can be challenging if the target is flexible and the affinity range of the training compounds is narrow. For a data set of 44 pyrrolidine carboxamide inhibitors of the mycobacterial enoyl-ACP-reductase InhA this proved to be case, as scoring methods of various origin and complexity did not succeed in providing practically useful correlations with experimental inhibition data. In contrast, logistic regression models for activity-based classification trained with combinations of scoring functions led to good separation of the more active inhibitors from the weakest compounds...
December 24, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29325701/developmental-cognitive-neuroscience-using-latent-change-score-models-a-tutorial-and-applications
#3
REVIEW
Rogier A Kievit, Andreas M Brandmaier, Gabriel Ziegler, Anne-Laura van Harmelen, Susanne M M de Mooij, Michael Moutoussis, Ian M Goodyer, Ed Bullmore, Peter B Jones, Peter Fonagy, Ulman Lindenberger, Raymond J Dolan
Assessing and analysing individual differences in change over time is of central scientific importance to developmental neuroscience. However, the literature is based largely on cross-sectional comparisons, which reflect a variety of influences and cannot directly represent change. We advocate using latent change score (LCS) models in longitudinal samples as a statistical framework to tease apart the complex processes underlying lifespan development in brain and behaviour using longitudinal data. LCS models provide a flexible framework that naturally accommodates key developmental questions as model parameters and can even be used, with some limitations, in cases with only two measurement occasions...
November 22, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29325561/workforce-patterns-in-the-prevention-of-mother-to-child-transmission-of-hiv-in-c%C3%A3-te-d-ivoire-a-qualitative-model
#4
Brianne H Rowan, Julia Robinson, Adam Granato, Claire Konan Bla, Seydou Kouyaté, Guy Vincent Djety, Kouamé Abo, Ahoua Koné, Stephen Gloyd
BACKGROUND: Côte d'Ivoire continues to struggle with one of the highest rates of mother-to-child HIV transmission in West Africa, previously thought to be in part due to suboptimal workforce patterns. This study aimed to understand the process through which workforce patterns impact prevention of mother-to child transmission of HIV (PMTCT) program success, from the perspective of healthcare workers in Côte d'Ivoire. METHODS: A total of 142 semi-structured interviews were conducted with physicians, midwives, nurses, community counselors, social workers, pharmacists, management personnel and health aides from a nationally representative sample of 48 PMTCT sites across Côte d'Ivoire...
January 11, 2018: Human Resources for Health
https://www.readbyqxmd.com/read/29316894/access-to-primary-and-specialized-somatic-health-care-for-persons-with-severe-mental-illness-a-qualitative-study-of-perceived-barriers-and-facilitators-in-swedish-health-care
#5
Elisabeth Björk Brämberg, Jarl Torgerson, Anna Norman Kjellström, Peder Welin, Marie Rusner
BACKGROUND: Persons with severe mental illness (e.g. schizophrenia, bipolar disorder) have a high prevalence of somatic conditions compared to the general population. Mortality data in the Nordic countries reveal that these persons die 15-20 years earlier than the general population. Some factors explaining this high prevalence may be related to the individuals in question; others arise from the health care system's difficulty in offering somatic health care to these patient groups. The aim of the present study was therefore to explore the experiences and views of patients, relatives and clinicians regarding individual and organizational factors which facilitate or hinder access to somatic health care for persons with severe mental illness...
January 9, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29316649/%C3%A2-cat-3-mots-nanosatellite-mission-for-optical-multispectral-and-gnss-r-earth-observation-concept-and-analysis
#6
Jordi Castellví, Adriano Camps, Jordi Corbera, Ramon Alamús
The ³Cat-3/MOTS (3: Cube, Cat: Catalunya, 3: 3rd CubeSat mission/Missió Observació Terra Satèl·lit) mission is a joint initiative between the Institut Cartogràfic i Geològic de Catalunya (ICGC) and the Universitat Politècnica de Catalunya-BarcelonaTech (UPC) to foster innovative Earth Observation (EO) techniques based on data fusion of Global Navigation Satellite Systems Reflectometry (GNSS-R) and optical payloads. It is based on a 6U CubeSat platform, roughly a 10 cm × 20 cm × 30 cm parallelepiped...
January 6, 2018: Sensors
https://www.readbyqxmd.com/read/29314903/national-athletic-trainers-association-position-statement-prevention-of-anterior-cruciate-ligament-injury
#7
Darin A Padua, Lindsay J DiStefano, Timothy E Hewett, William E Garrett, Stephen W Marshall, Grace M Golden, Sandra J Shultz, Susan M Sigward
OBJECTIVE:   To provide certified athletic trainers, physicians, and other health care and fitness professionals with recommendations based on current evidence regarding the prevention of noncontact and indirect-contact anterior cruciate ligament (ACL) injuries in athletes and physically active individuals. BACKGROUND:   Preventing ACL injuries during sport and physical activity may dramatically decrease medical costs and long-term disability. Implementing ACL injury-prevention training programs may improve an individual's neuromuscular control and lower extremity biomechanics and thereby reduce the risk of injury...
January 9, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29314274/small-angle-x-ray-scattering-and-cross-linking-for-data-assisted-protein-structure-prediction-in-casp-12-with-prospects-for-improved-accuracy
#8
Tadeusz L Ogorzalek, Greg L Hura, Adam Belsom, Kathryn H Burnett, Andriy Kryshtafovych, John A Tainer, Juri Rappsilber, Susan E Tsutakawa, Krzysztof Fidelis
Experimental data offers empowering constraints for structure prediction. These constraints can be used to filter equivalently scored models or more powerfully within optimization functions toward prediction. In CASP12, Small Angle X-ray Scattering (SAXS) and Cross-Linking Mass Spectrometry (CLMS) data, measured on an exemplary set of novel fold targets, were provided to the CASP community of protein structure predictors. As HT, solution-based techniques, SAXS and CLMS can efficiently measure states of the full-length sequence in its native solution conformation and assembly...
January 4, 2018: Proteins
https://www.readbyqxmd.com/read/29313237/simians-in-the-shape-school-a-comparative-study-of-executive-attention
#9
Kristin French, Michael J Beran, Kimberly Andrews Espy, David A Washburn
Executive functions (EF) have been studied extensively in children and adults. However, EF tasks for young children can be difficult to administer and interpret. Espy (1997, Developmental Neuropsychology, 13, 495-499) designed the Shape School task to measure inhibition and switching in preschool-aged children. Shape School presents cartoon-like characters that children must flexibly name by their color, their shape, or both, depending on cues that indicate the appropriate rule. Shape School has been found to be age sensitive as well as predictive of performance on other EF tasks...
January 8, 2018: Learning & Behavior
https://www.readbyqxmd.com/read/29310744/new-public-management-in-iran-s-health-complex-a-management-framework-for-primary-health-care-system
#10
Jafar Sadegh Tabrizi, Elaheh HaghGoshayie, Leila Doshmangir, Mahmood Yousefi
BACKGROUND: New public management (NPM) was developed as a management reform to improve the efficiency and effectiveness in public organizations, especially in health sector. Using the features of private sector management, the managers of health organizations may try to implement the elements of NPM with the hope to improve the performance of their systems. Aims Our aim in the present study was to identify the elements and infrastructures suitable for implementing NPM in the Iranian health complex...
January 9, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29309940/interim-analysis-of-a-prospective-multi-institutional-study-of-surgery-resident-experience-with-flexibility-in-surgical-training
#11
Darren R Cullinan, Paul E Wise, Keith A Delman, John R Potts, Michael M Awad, Timothy J Eberlein, Mary E Klingensmith
BACKGROUND: The Flexibility in Surgical Training (FIST) consortium project was designed to evaluate the feasibility and resident outcomes of optional subspecialty-focused training within general surgery residency training. STUDY DESIGN: Following approval by the American Board of Surgery, R4 and R5 residents were permitted to customize up to 12 of the final 24 months of residency for early tracking into one of nine subspecialty tracks. A prospective IRB-approved study was designed across seven institutions to evaluate the impact of this option on operative experience, in-service exam (ABSITE) and ACGME milestone performance, and resident and program director (PD) perceptions...
January 5, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29302796/prehabilitation-a-new-area-of-integration-between-geriatricians-anesthesiologists-and-exercise-therapists
#12
Francesco Carli, Vanessa Ferreira
Surgery in combination with risk factors such as poor physical and nutritional status have detrimental effects on short- and long-term aspects of recovery and quality of life, especially in elderly patients whose functional reserve is limited. Strategies to minimize these effects and accelerate return to baseline levels have focused on the intra- and post-operative period; however, this may not be the most opportune time to intervene. Instead, the preoperative period may be a more emotionally salient and physically enabling time to initiate an intervention aimed at attenuating surgical stress and enhancing recovery after surgery...
January 4, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29298691/volition-adaptive-control-for-gait-training-using-wearable-exoskeleton-preliminary-tests-with-incomplete-spinal-cord-injury-individuals
#13
Vijaykumar Rajasekaran, Eduardo López-Larraz, Fernando Trincado-Alonso, Joan Aranda, Luis Montesano, Antonio J Del-Ama, Jose L Pons
BACKGROUND: Gait training for individuals with neurological disorders is challenging in providing the suitable assistance and more adaptive behaviour towards user needs. The user specific adaptation can be defined based on the user interaction with the orthosis and by monitoring the user intentions. In this paper, an adaptive control model, commanded by the user intention, is evaluated using a lower limb exoskeleton with incomplete spinal cord injury individuals (SCI). METHODS: A user intention based adaptive control model has been developed and evaluated with 4 incomplete SCI individuals across 3 sessions of training per individual...
January 3, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29297405/research-capacity-building-integrated-into-phit-projects-leveraging-research-and-research-funding-to-build-national-capacity
#14
Bethany L Hedt-Gauthier, Roma Chilengi, Elizabeth Jackson, Cathy Michel, Manuel Napua, Jackline Odhiambo, Ayaga Bawah
BACKGROUND: Inadequate research capacity impedes the development of evidence-based health programming in sub-Saharan Africa. However, funding for research capacity building (RCB) is often insufficient and restricted, limiting institutions' ability to address current RCB needs. The Doris Duke Charitable Foundation's African Health Initiative (AHI) funded Population Health Implementation and Training (PHIT) partnership projects in five African countries (Ghana, Mozambique, Rwanda, Tanzania and Zambia) to implement health systems strengthening initiatives inclusive of RCB...
December 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29294884/evaluating-the-effectiveness-of-online-training-for-a-comprehensive-violence-against-women-program-a-pilot-study
#15
Nicole Etherington, Linda Baker, Marlene Ham, Denise Glasbeek
Evaluating violence against women (VAW) training is essential to moving the field forward with proven approaches that can improve service provision for survivors of violence. Given existing resource constraints involved in VAW work, online training represents an economical and flexible option; however, existing evaluations of online programs in the VAW field are scant and face a variety of limitations. This study aimed to fill this gap by using a pre-/posttest design, comparison group, and mixed-method analysis to assess the effectiveness and value of an online training program...
August 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294732/individual-versus-group-cognitive-behavioral-therapy-for-partner-violent-men-a-preliminary-randomized-trial
#16
Christopher M Murphy, Christopher I Eckhardt, Judith M Clifford, Adam D Lamotte, Laura A Meis
A randomized clinical trial tested the hypothesis that a flexible, case formulation-based, individual treatment approach integrating motivational interviewing strategies with cognitive-behavioral therapy (ICBT) is more efficacious than a standardized group cognitive-behavioral approach (GCBT) for perpetrators of intimate partner violence (IPV). Forty-two men presenting for services at a community domestic violence agency were randomized to receive 20 sessions of ICBT or a 20-week group cognitive-behavioral therapy (CBT) program...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29289581/physical-exercise-improves-strength-balance-mobility-and-endurance-in-people-with-cognitive-impairment-and-dementia-a-systematic-review
#17
Freddy Mh Lam, Mei-Zhen Huang, Lin-Rong Liao, Raymond Ck Chung, Timothy Cy Kwok, Marco Yc Pang
QUESTION: Does physical exercise training improve physical function and quality of life in people with cognitive impairment and dementia? Which training protocols improve physical function and quality of life? How do cognitive impairment and other patient characteristics influence the outcomes of exercise training? DESIGN: Systematic review with meta-analysis of randomised trials. PARTICIPANTS: People with mild cognitive impairment or dementia as the primary diagnosis...
December 27, 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29285411/simple-training-tricks-for-mastering-and-taming-bypass-procedures-in-neurosurgery
#18
Ahmad Hafez, Rahul Raj, Michael T Lawton, Mika Niemelä
Background: Neurosurgeons devoted to bypass neurosurgery or revascularization neurosurgery are becoming scarcer. From a practical point of view, "bypass neurosurgeons" are anastomosis makers, vessels technicians, and time-racing repairers of vessel walls. This requires understanding the key features and hidden tricks of bypass surgery. The goal of this paper is to provide simple and inexpensive tricks for taming the art of bypass neurosurgery. Most of these tricks and materials described can be borrowed, donated, or purchased inexpensively...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29283621/-joy-in-practice-requires-workforce-well-being
#19
Christine N Runyan
In this column, the president of the Collaborative Family Healthcare Association notes that the national conversation about physician burnout has recently shifted to discussing the importance of finding joy in practice. However, she is concerned the current culture of medicine, hidden curricula in medical training, a draconian financial system, and an emotionally ill-prepared workforce may preclude sustained joy in practice. Formal curricula do not include resiliency skills, mindfulness, cognitive flexibility and reframing, conflict-resolution skills, emotional-regulation skills, or how to practice empathy and compassion without crumbling from vicarious trauma...
December 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29283421/automatic-classification-of-sub-techniques-in-classical-cross-country-skiing-using-a-machine-learning-algorithm-on-micro-sensor-data
#20
Ole Marius Hoel Rindal, Trine M Seeberg, Johannes Tjønnås, Pål Haugnes, Øyvind Sandbakk
The automatic classification of sub-techniques in classical cross-country skiing provides unique possibilities for analyzing the biomechanical aspects of outdoor skiing. This is currently possible due to the miniaturization and flexibility of wearable inertial measurement units (IMUs) that allow researchers to bring the laboratory to the field. In this study, we aimed to optimize the accuracy of the automatic classification of classical cross-country skiing sub-techniques by using two IMUs attached to the skier's arm and chest together with a machine learning algorithm...
December 28, 2017: Sensors
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