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Ambulatory oxygen

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https://www.readbyqxmd.com/read/29315934/effect-of-euk-134-on-akt-mtor-signaling-in-the-rat-soleus-during-7-days-of-mechanical-unloading
#1
J Matthew Kuczmarski, Jeff M Hord, Yang Lee, Vinicius Guzzoni, Dinah Rodriguez, Matthew S Lawler, Erika L Garcia-Villatoro, Dylan Holly, Patrick Ryan, Kristian Falcon, Marcela Garcia, Mariana Janini Gomes, James D Fluckey, John M Lawler
Mechanical unloading stimulates rapid changes in skeletal muscle morphology, characterized by atrophy of muscle fiber cross-sectional area (CSA) and a partial fiber-type shift from slow to fast-twitch. Recent studies revealed that oxidative stress contributes to activation of FoxO3a, proteolytic signaling and unloading-induced muscle atrophy via translocation of the mu-splice variant of neuronal nitric oxide synthase (nNOSμ) and activation of FoxO3a. Yet, there is limited understanding of the role of reactive oxygen species (ROS) on the Akt-mTOR pathway signaling during unloading...
January 8, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29304735/effect-of-single-dose-dexmedetomidine-on-postoperative-recovery-after-ambulatory-ureteroscopy-and-ureteric-stenting-a-double-blind-randomized-controlled-study
#2
I I Shariffuddin, W H Teoh, S Wahab, C Y Wang
BACKGROUND: Ambulatory surgery has recently gain popularity, as it is a good method of optimizinghospital resources utilization. To support ambulatory surgery, anaesthetic goals nowrevolve around patients' early recovery with minimal pain and nausea, expedientdischarge home and prompt resumption of activities of daily living. In this study, weevaluated the effect of a single pre-induction dose of dexmedetomidine on anaestheticrequirements, postoperative pain and clinical recovery after ambulatory ureteroscopy andureteric stenting under general anaesthesia...
January 5, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29303603/sleep-apnoea-in-patients-with-nocturnal-hypertension-a-multicentre-study-in-the-czech-republic
#3
M Hobzova, K Sonka, M Pretl, J Vaclavik, E Kriegova, M Radvansky, J Zapletalova, M Plackova, V Kolek
Sleep apnoea (SA) is common in patients with hypertension. Nowadays, limited data on the prevalence of SA in nocturnal hypertension (NH) exist. We, therefore, studied the occurrence of SA in Czech patients and its association with 24-hour ambulatory blood pressure monitoring (ABPM), breathing disturbances in sleep, anthropometric data, Mallampati score and Epworth sleepiness scale (ESS) using the Apnea Link device. Undiagnosed SA was found in 72.9% patients (29.3% mild, 26.6% moderate, 17.0% severe) of 188 patients with NH measured by ABPM...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29272974/home-oxygen-therapy-re-thinking-the-role-of-devices
#4
Andrea S Melani, Piersante Sestini, Paola Rottoli
A range of devices are available for delivering and monitoring home oxygen therapy (HOT). Guidelines do not give indications for the choice of the delivery device but recommend the use of an ambulatory system in subjects on HOT whilst walking. Areas covered: We provide a clinical overview of HOT and review traditional and newer delivery and monitoring devices for HOT. Despite relevant technology advancements, clinicians, faced with many challenges when they prescribe oxygen therapy, often remain familiar to traditional devices and continuous flow delivery of oxygen...
January 4, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29240631/in-vivo-5-day-animal-studies-of-a-compact-wearable-pumping-artificial-lung
#5
Shalv P Madhani, Brian J Frankowski, Sang-Ho Ye, Greg W Burgreen, William R Wagner, Robert Kormos, Jonathan D'Cunha, William J Federspiel
Recent studies show improved outcomes in ambulated lung failure patients. Ambulation still remains a challenge in these patients. This necessitates development of more compact and less cumbersome respiratory support specifically designed to be wearable. The Paracorporeal Ambulatory Assist Lung (PAAL) is being designed for providing ambulatory support in lung failure patients during bridge to transplant or recovery. We previously published in vitro and acute in vivo results of the PAAL. This study further evaluates the PAAL for 5 days...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29240630/in-vitro-characterization-of-the-pittsburgh-pediatric-ambulatory-lung
#6
Ryan A Orizondo, Alexandra G May, Shalv P Madhani, Brian J Frankowski, Greg W Burgreen, Peter D Wearden, William J Federspiel
Acute and chronic respiratory failure are a significant source of pediatric morbidity and mortality. Current respiratory support options used to bridge children to lung recovery or transplantation typically render them bedridden and can worsen long-term patient outcomes. The Pittsburgh Pediatric Ambulatory Lung (P-PAL) is a wearable pediatric blood pump and oxygenator (0.3 m surface area) integrated into a single compact unit that enables patient ambulation. The P-PAL is intended for long-term use and designed to provide up to 90% of respiratory support in children weighing 5-25 kg...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29205886/ambulatory-central-va-ecmo-with-biventricular-decompression-for-acute-cardiogenic-shock
#7
Prashant Rao, Benjamin Alouidor, Richard Smith, Zain Khalpey
We describe the off-pump insertion of a biventricular assist device with extra-corporeal membrane oxygenation (ECMO): a novel technique that allows for ambulatory central veno-arterial (VA) ECMO with direct biventricular decompression.
December 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29193512/exertional-hypoxemia-is-more-severe-in-fibrotic-interstitial-lung-disease-than-in-copd
#8
Jean P Du Plessis, Senan Fernandes, Rakin Jamal, Pat Camp, Kerri Johannson, Michele Schaeffer, Pearce G Wilcox, Jordan A Guenette, Christopher J Ryerson
BACKGROUND AND OBJECTIVE: Despite its clinical and prognostic significance, few studies have evaluated the severity of exertional oxygen desaturation in fibrotic interstitial lung disease (ILD). Our objectives were to identify clinical and physiological variables that predict the extent of exertional oxygen desaturation in fibrotic ILD and to quantify the severity of desaturation compared to chronic obstructive pulmonary disease (COPD). METHODS: This retrospective study compared the results of 6-min walk test (6MWT) performed while breathing room air in fibrotic ILD patients and COPD patients eligible for pulmonary rehabilitation...
November 28, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29185640/ambulatory-and-short-burst-oxygen-for-interstitial-lung-disease
#9
Debbi Atkinson
The mission of the Cochrane Nursing Care Field (CNCF) is to improve health outcomes through increasing the use of the Cochrane Library and supporting Cochrane's role by providing an evidence base for nurses and healthcare professionals who deliver, lead or research nursing care. The CNCF produces Cochrane Corner columns, summaries of recent nursing-care-relevant Cochrane Reviews that are regularly published in collaborating nursing-related journals. Information on the processes CNCF has developed can be accessed at: cncf...
November 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29184538/circulating-irisin-is-reduced-in-male-patients-with-type-1-and-type-2-myotonic-dystrophies
#10
Elena Dozio, Elena Passeri, Rosanna Cardani, Stefano Benedini, Carmen Aresta, Rea Valaperta, Massimiliano Corsi Romanelli, Giovanni Meola, Valeria Sansone, Sabrina Corbetta
Context: Myotonic dystrophies (DM) are dominantly inherited muscle disorders characterized by myotonia, muscle weakness, and wasting. The reasons for sarcopenia in DMs are uncleared and multiple factors are involved. Irisin, a positive hormone regulator of muscle growth and bone, may play a role. Objectives: To investigate (1) circulating irisin in a series of DM1 and DM2 male patients compared with healthy controls and (2) the relationships between irisin and anthropometric, metabolic and hormonal parameters...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29157582/serum-lipid-profile-sleep-disordered-breathing-and-blood-pressure-in-the-elderly-a-10-year-follow-up-of-the-proof-synapse-cohort
#11
Denis Monneret, Jean-Claude Barthélémy, David Hupin, Delphine Maudoux, Sébastien Celle, Emilia Sforza, Frédéric Roche
OBJECTIVES: Dyslipidemia, sleep-disordered breathing (SDB) and hypertension are comorbid factors evidenced in adults, but poorly studied in old people. This study aimed to examine the long-term evolution of the serum lipid profile, and its relationships with SDB and blood pressure (BP) in the elderly. METHODS: A ten-year follow-up of the prospective Prognostic Indicator of Cardiovascular and Cerebrovascular Events (PROOF) and the Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea (SYNAPSE) cohort, which initially included 1011 elderly subjects from the general population, and who were untreated by continuous positive airway pressure (CPAP)...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29150775/influences-of-obstructive-sleep-apnea-on-blood-pressure-variability-might-not-be-limited-only-nocturnally-in-middle-aged-hypertensive-males
#12
Liang Shao, Mulalibieke Heizhati, Xiaoguang Yao, Yingchun Wang, Suofeiya Abulikemu, Delian Zhang, Ling Zhou, Jing Hong, Nanfang Li
PURPOSE: In this cross-sectional study, we analyzed the potential association between sleep measures and blood pressure variability. METHODS: Ninety-three middle-aged hypertensive males, who underwent polysomnography and 24-h ambulatory blood pressure monitoring, were enrolled. Blood pressure variability was assessed by blood pressure standard deviation. Obstructive sleep apnea (apnea hypopnea index ≥ 15) was diagnosed in 52 (55.91%) patients. Mean body mass index and age were 27...
November 17, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29131746/topical-oxygen-therapy-promotes-the-healing-of-chronic-diabetic-foot-ulcers-a-pilot-study
#13
P D Hayes, N Alzuhir, G Curran, I M Loftus
OBJECTIVE: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29117079/integration-of-data-to-establish-a-standard-operating-procedure-for-the-diabetic-patient-undergoing-hyperbaric-oxygen-therapy
#14
Katherine George, Dianne Ross, Lynn Rowe
PURPOSE: The purpose of this study was to describe occurrences of hypoglycemia in the diabetic population undergoing hyperbaric oxygen therapy (HBOT). We also examined 2 secondary aims: link industry standards for management of hypoglycemia in the general diabetic population to the HBOT environment; and integrate HBOT data into an electronic health record system, as patients transition across inpatient and outpatient services and settings. DESIGN: A retrospective, descriptive study...
November 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29100885/a-phase-ii-clinical-trial-of-low-dose-inhaled-carbon-monoxide-in-idiopathic-pulmonary-fibrosis
#15
Ivan O Rosas, Hilary J Goldberg, Harold R Collard, Souheil El-Chemaly, Kevin Flaherty, Gary M Hunninghake, Joseph A Lasky, David J Lederer, Roberto Machado, Fernando J Martinez, Rie Maurer, Danielle Teller, Imre Noth, Elizabeth Peters, Ganesh Raghu, Joe G N Garcia, Augustine M K Choi
BACKGROUND: Preclinical studies have demonstrated that low-dose carbon monoxide (CO) can abrogate experimental lung fibrosis. To test the therapeutic role of inhaled CO, we designed a clinical study in patients with idiopathic pulmonary fibrosis (IPF). METHODS: We conducted a multicenter, phase IIa, double-blinded, sham-controlled, clinical trial. Patients with IPF were randomized to treatment with inhaled CO at 100 to 200 parts per million or to inhaled 21% oxygen for 2 h daily, twice weekly, for 12 weeks...
October 31, 2017: Chest
https://www.readbyqxmd.com/read/29095000/the-effects-of-a-low-carbohydrate-diet-on-oxygen-saturation-in-heart-failure-patients-a-randomized-controlled-clinical-trial
#16
Dulce González-Islas, Arturo Orea-Tejeda, Lilia Castillo-Martínez, Gabriela Olvera-Mayorga, Wendy Daniella Rodríguez-García, Cira Santillán-Díaz, Candace Keirnes-Davis, Nayeli Vaquero-Barbosa
INTRODUCTION: Nutritional therapy in heart failure (HF) patients has been focused on fluid and sodium restriction with the aim of decreasing volume overload. However, these recommendations are not well established and sometimes controversial. OBJECTIVE: To evaluate the effect of the consumption of a low-carbohydrate diet on oxygen saturation, body composition and clinical variables during two months of follow-up in chronic, stable heart failure patients. METHODS: In a parallel group randomized controlled clinical trial, 88 ambulatory patients were randomly assigned to a low-carbohydrate diet group (40% carbohydrates, 20% protein and 40% fats [12% saturated, 18% monounsaturated and 10% polyunsaturated]) or a standard diet group (50% carbohydrates, 20% protein and 30% fats [10% saturated, 10% monounsaturated and 10% polyunsaturated]) for two months...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29080064/ambulatory-screening-for-obstructive-sleep-apnea-in-patients-with-resistant-arterial-hypertension
#17
Monika Kamasová, Jan Václavík, Tomáš Václavík, Milada Hobzová, Eva Kociánová, Miloš Táborský
OBJECTIVE: Obstructive sleep apnea (OSA) is one of the most common causes of secondary arterial hypertension. It is important to rule out OSA as a cause of resistant hypertension. The ApneaLink device is a simple and cost-efficient outpatient examination, but its usefulness in screening OSA in resistant hypertension has not yet been evaluated. METHODS: A total of 69 patients with resistant arterial hypertension were enrolled. Patients underwent a physical examination, including the use of ApneaLink, followed by respiratory polygraphy...
October 27, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29062634/septic-shock-following-prostate-biopsy-aggressive-limb-salvage-for-extremities-after-pressor-induced-ischemic-gangrene
#18
Jocelyn Lu, Tammer Elmarsafi, Chrisovalantis Lakhiani, Sarah R Sher, Christopher Attinger, Karen K Evans
Vasopressors used to treat patients with septic shock can cause ischemic necrosis of appendages such as the ears and nose, as well as the extremities. Cases of quadruple-extremity necrosis have high morbidity and mortality, and a profound negative impact on quality of life. This case report details the successful limb salvage and return to function using free tissue transfer as a means to salvage bilateral lower extremities in a patient who suffered vasopressor-induced ischemia of upper and lower extremities after prostate biopsy-induced septic shock...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28986731/successful-management-of-prolonged-venovenous-extracorporeal-membrane-oxygenation-in-an-octogenarian
#19
Masami Takagaki, Hiroki Yamaguchi, Shinichi Mitsuyama, Tasuku Kadowaki, Takeshi Ando
Venovenous extracorporeal membrane oxygenation is now an established treatment for acute respiratory distress syndrome. However, this treatment remains rare in octogenarians and is associated with poor outcomes. An 81-year-old man with a history of chronic obstructive pulmonary disease and heavy smoking underwent mitral and tricuspid valve repair and the Maze procedure for mitral and tricuspid regurgitation and paroxysmal atrial fibrillation. Although he was extubated the following day, his postoperative course was complicated with pneumonia followed by acute respiratory distress syndrome...
December 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28985855/safety-of-perioperative-ketorolac-administration-in-pediatric-appendectomy
#20
Hibbut-Ur-Rauf Naseem, Robert Michael Dorman, George Ventro, David H Rothstein, Kaveh Vali
BACKGROUND: Recent studies in adults undergoing gastrointestinal surgeries show an increased rate of complications with the use of ketorolac. This calls into question the safety of ketorolac in certain procedures. We sought to evaluate the impact of perioperative ketorolac administration on outcomes in pediatric appendectomy. METHODS: The Pediatric Health Information System database was queried for patients aged 5-17 y with a primary diagnosis of appendicitis and a primary procedure of appendectomy during the period 2010-2014...
October 2017: Journal of Surgical Research
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