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https://www.readbyqxmd.com/read/27909734/klf4-inhibits-tumor-growth-and-metastasis-by-targeting-microrna-31-in-human-hepatocellular-carcinoma
#1
Chuan Tian, Shanshan Yao, Li Liu, Youcheng Ding, Qingwang Ye, Xiao Dong, Yong Gao, Ning Yang, Qi Li
MicroRNAs (miRNAs or miRs) are short, endogenous non-coding RNA molecules, demonstrating abnormal expression in cancer initiation and progression. In this study, we profiled 18 differentially regulated miRNAs, including miRNA‑31, using miRNA array. Kruppel (or Krüppel)-like factor 4 (Klf4) is a transcription factor and putative tumor suppressor. Both were found to be significantly downregulated in liver cancer tissues and cells. However, little is known about the correlation between Klf4 and miRNA‑31 in hepatocellular carcinoma (HCC)...
November 24, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27904131/mir-31-regulates-rho-associated-kinase-myosin-light-chain-rock-mlc-pathway-and-inhibits-gastric-cancer-invasion-roles-of-rhoa
#2
Zhuo Chen, Shengnan Liu, Yuan Xia, Kejian Wu
BACKGROUND This study evaluated how the expression of miR-31 can be used to detect gastric cancer (GC) to help illuminate the role of miR-31 and RhoA in GC cells. MATERIAL AND METHODS We carried out our experiments using tissue specimens from 70 GC patients. The relative expression of miR-31 and RhoA mRNA in tissues and cells was detected by RT-PCR. The expression level of RhoA protein was detected by immunohistochemistry. GC cell line BGC-823 was transfected with six groups of vectors: blank group, NC (negative control) group, miR-31 mimics group, miR-31 mimics + RhoA group, miR-31 mimics + ROCK group, and miR-31 mimics + MLCK agonist group...
December 1, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27901018/the-signaling-axis-of-microrna-31-interleukin-25-regulates-th1-th17-mediated-inflammation-response-in-colitis
#3
T Shi, Y Xie, Y Fu, Q Zhou, Z Ma, J Ma, Z Huang, J Zhang, J Chen
Interleukin-25 (IL-25) is an important regulatory cytokine that has a key role on mucosal immune tolerance during inflammation response. However, the molecular mechanism that regulates the colonic IL-25 expression in Crohn's disease (CD) remains unclear. In this study, IL-25 level was proved to decrease in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice and IL-10 knockout (KO) spontaneous colitis mice. An inverse correlation between IL-25 and miR-31 was discovered in the colons from model mice and CD patients...
November 30, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27885434/evaluation-of-mir-21-and-mir-375-as-prognostic-biomarkers-in-oesophageal-cancer-in-high-risk-areas-in-china
#4
Yutong He, Jing Jin, LiQun Wang, Yuejiao Hu, Di Liang, Huichai Yang, Yueping Liu, Baoen Shan
MicroRNAs have been associated with prognosis in oesophageal cancer (EC), suggesting that miRNAs could play a role in guiding treatment decisions. The aim of this study was to evaluate the prognostic potential of miRNAs found to be associated with zinc deficiency in a geographical area with a high incidence of EC. miRNAs found to be associated with zinc deficiency were isolated from EC cell lines cultured with various Zn levels. The expression levels of the miRNAs were quantified using qRT-PCR. The potential prognostic value of the selected miRNAs was assessed in a cohort study of 88 patients from an area in China with a high incidence of EC...
November 24, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27825112/mir-31-regulates-the-cisplatin-resistance-by-targeting-src-in-gallbladder-cancer
#5
Maolan Li, Wei Chen, Hongchen Zhang, Yong Zhang, Fayong Ke, Xiangsong Wu, Yijian Zhang, Mingzhe Weng, Yingbin Liu, Wei Gong
BACKGROUND: Gallbladder cancer (GBC) is a malignant tumor highly resistant to chemotherapy. MicroRNAs (miRNAs) are found extensively involved in modulation of carcinogenesis and chemoresistance. This study aimed to investigate cisplatin (DDP)-susceptibility regulated by expression of the miRNAs and underlying pathways in GBC. RESULTS: The microRNA-31 (miR-31) was selected by microarray due to the biggest fold change between DDP-resistant and parental cells. Ectopic overexpression of miR-31 decreased cell proliferation, viability and invasion capacity, but promoted apoptosis in DDP-resistant cells and in xenograft tumor models...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27793031/mir-31-affects-colorectal-cancer-cells-by-inhibiting-autophagy-in-cancer-associated-fibroblasts
#6
Xiaodong Yang, Xiaohui Xu, Junjia Zhu, Shuyu Zhang, Yong Wu, Yongyou Wu, Kui Zhao, Chungen Xing, Jianping Cao, Hong Zhu, Ming Li, Zhenyu Ye, Wei Peng
Autophagy is a double-edged sword in tumor development. Recent studies have found that miRNAs have an inhibitory effect on the regulation of autophagy. It has been reported that miR-31 plays an important role in the development of colorectal cancer. However, what role miR-31 plays in colorectal cancer-associated fibroblasts (CAFs) has not been determined. In this study, we confirmed that the expression of miR-31 in CAFs was higher than in normal colorectal fibroblasts (NFs). We also found that treatment of CAFs with miR-31 mimic inhibited the expression of the autophagy-related genes Beclin-1, ATG, DRAM and LC3...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27777637/integrating-dna-methylation-and-microrna-biomarkers-in-sputum-for-lung-cancer-detection
#7
Yun Su, HongBin Fang, Feng Jiang
BACKGROUND: Abnormal microRNA (miRNA) expressions and promoter methylation of genes detected in sputum may provide biomarkers for non-small lung cancer (NSCLC). Here, we evaluate the individual and combined analysis of the two classes of sputum molecular biomarkers for NSCLC detection. RESULTS: We analyze expression of 3 miRNAs (miR-21, miR-31, and miR-210) and methylation of 3 genes (RASSF1A, PRDM14, and 3OST2), which were previously identified as potential biomarkers for NSCLC, in sputum of a set of 117 stage I NSCLC patients and 174 cancer-free smokers...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27741296/post-transcriptional-regulation-of-toll-interacting-protein-in-the-intestinal-epithelium
#8
Yutaka Sugi, Kyoko Takahashi, Kenta Kurihara, Kazuaki Nakata, Hikari Narabayashi, Yuji Hamamoto, Makoto Suzuki, Masato Tsuda, Shigemasa Hanazawa, Akira Hosono, Shuichi Kaminogawa
Immune responses against gut microbiota should be minimized to avoid unnecessary inflammation at mucosal surface. In this study, we analyzed the expression patterns of Toll-interacting protein (Tollip), an inhibitor of TLRs and IL-1 family cytokine-related intracellular signaling, in intestinal epithelial cells (IECs). Comparable mRNA expression was observed in murine small and large IECs (S-IECs and L-IECs). However, Tollip protein was only detected in L-IECs, but not in S-IECs. Similar results were obtained in germ-free mice, indicating that L-IEC-specific TOLLIP expression does not depend on bacterial colonization...
2016: PloS One
https://www.readbyqxmd.com/read/27729619/role-of-an-imbalanced-mirnas-axis-in-pathogenesis-of-psoriasis-novel-perspectives-based-on-review-of-the-literature
#9
Mao-Jie Wang, Yong-Yue Xu, Run-Yue Huang, Xiu-Min Chen, Hai-Ming Chen, Ling Han, Yu-Hong Yan, Chuan-Jian Lu
BACKGROUND: Specific profile of microRNAs (miRNAs, miR) expressed in psoriasis has been identified in the past few years, while the studies on roles and molecular mechanisms of these miRNAs are still on the way. In our previous study, four specific miRNAs (miR-31, miR-203, hsa-miR-99a and miR-125b) were found to be specifically altered in psoriatic lesions.We therefore conducted a systematic literature review in this study to reveal the role of these miRNAs in the pathogenesis of psoriasis in order to inform future research...
October 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27695346/microrna-expression-profiles-predict-progression-and-clinical-outcome-in-lung-adenocarcinoma
#10
Kang Lin, Tao Xu, Bang-Shun He, Yu-Qin Pan, Hui-Ling Sun, Hong-Xin Peng, Xiu-Xiu Hu, Shu-Kui Wang
Lung cancer is one of the leading causes of cancer death worldwide. Accumulating evidence has indicated that microRNAs (miRNAs) can be proposed as promising diagnostic and prognostic markers for various cancers. The current study analyzed the miRNA expression profiles of 418 lung adenocarcinoma (LUAD) cases obtained from The Cancer Genome Atlas dataset, with the aim to investigate the relationship of miRNAs with progression and prognosis of LUAD. A total of 185 miRNAs were found to be differentially expressed between LUAD tumor tissues and adjacent normal tissues...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27659519/profiles-of-mirnas-matched-to-biology-in-aromatase-inhibitor-resistant-breast-cancer
#11
Reiner Hoppe, Ping Fan, Florian Büttner, Stefan Winter, Amit K Tyagi, Heather Cunliffe, V Craig Jordan, Hiltrud Brauch
Aromatase inhibitor (AI) resistance during breast cancer treatment is mimicked by MCF-7:5C (5C) and MCF-7:2A (2A) cell lines that grow spontaneously. Survival signaling is reconfigured but cells are vulnerable to estradiol (E2)-inducible apoptosis. These model systems have alterations of stress related pathways including the accumulation of endoplasmic reticulum, oxidative, and inflammatory stress that occur prior to E2-induced apoptosis. We investigated miRNA expression profiles of 5C and 2A to characterize their AI resistance phenotypes...
September 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27634012/aging-associated-changes-in-microrna-expression-profile-of-internal-anal-sphincter-smooth-muscle-role-of-microrna-133a
#12
Jagmohan Singh, Ettickan Boopathi, Sankar Addya, Benjamin Phillips, Isidore Rigoutsos, Raymond B Penn, Satish Rattan
A comprehensive genomic and proteomic, computational, and physiological approach was employed to examine the (previously unexplored) role of microRNAs (miRNAs) as regulators of internal anal sphincter (IAS) smooth muscle contractile phenotype and basal tone. miRNA profiling, genome-wide expression, validation, and network analyses were employed to assess changes in mRNA and miRNA expression in IAS smooth muscles from young vs. aging rats. Multiple miRNAs, including rno-miR-1, rno-miR-340-5p, rno-miR-185, rno-miR-199a-3p, rno-miR-200c, rno-miR-200b, rno-miR-31, rno-miR-133a, and rno-miR-206, were found to be upregulated in aging IAS...
November 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27632531/analysis-of-serum-microrna-expression-profiles-and-comparison-with-small-intestinal-microrna-expression-profiles-in-weaned-piglets
#13
Xin Tao, Ziwei Xu, Xiaoming Men
Weaning stress induces tissue injuries and impairs health and growth in piglets, especially during the first week post-weaning. MicroRNAs (miRNAs) play vital roles in regulating stresses and diseases. Our previous study found multiple differentially expressed miRNAs in small intestine of piglets at four days post-weaning. To better understand the roles of miRNAs during weaning stress, we analyzed the serum miRNA expressional profile in weaned piglets (at four days post-weaning) and in suckling piglets (control) of the same age using miRNA microarray technology...
2016: PloS One
https://www.readbyqxmd.com/read/27630355/efficacy-and-toxicity-of-panitumumab-after-progression-on-cetuximab-and-predictive-value-of-mir-31-5p-in-metastatic-wild-type-kras-colorectal-cancer-patients
#14
Igor Kiss, Jitka Mlcochova, Zbynek Bortlicek, Alexandr Poprach, Jiri Drabek, Petra Vychytilova-Faltejskova, Marek Svoboda, Tomas Buchler, Stanislav Batko, Ales Ryska, Marian Hajduch, Ondrej Slaby
BACKGROUND: In metastatic colorectal cancer (mCRC), panitumumab is generally considered to be ineffective after the progression on cetuximab therapy. However, few studies have demonstrated that a small subset of mCRC patients may benefit from panitumumab in this setting. PATIENTS AND METHODS: In our study, wild-type KRAS mCRC patients, enrolled into the nationwide Czech registry CORECT between January 2007 and December 2012, were screened for panitumumab therapy after progression on cetuximab...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27593563/mir-31-inhibits-migration-and-invasion-by-targeting-satb2-in-triple-negative-breast-cancer
#15
Long-Ji Luo, Fan Yang, Jia-Ji Ding, Da-Li Yan, Dan-Dan Wang, Su-Jin Yang, Li Ding, Jian Li, Dan Chen, Rong Ma, Jian-Zhong Wu, Jin-Hai Tang
Metastasis is the leading cause of death among breast cancer (BCa) patients and triple negative breast cancer (TNBC) as one of BCa subtypes exhibits the worst survival rate due to its highly aggressive and metastatic behavior. A growing body of research has shown that the dynamic expression of microRNAs (miRNAs) was intimately associated with tumor invasion and metastasis. Recent studies have demonstrated miR-31 as a metastasis-suppressor in breast cancer, but it is still known little about the mechanism of it suppresses metastasis...
December 5, 2016: Gene
https://www.readbyqxmd.com/read/27562321/microrna-146a-and-mir-99a-are-potential-biomarkers-for-disease-activity-and-clinical-efficacy-assessment-in-psoriasis-patients-treated-with-traditional-chinese-medicine
#16
Zhibo Yang, Bijun Zeng, Xueyong Tang, Haizhen Wang, Chang Wang, Zhangren Yan, Pan Huang, Yi Pan, Bin Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Psoriasis is a common chronic inflammatory skin disease. A number of clinical investigations have indicated that traditional Chinese medicine (TCM) is an effective and safe treatment for psoriasis. Zhuhuang Granule (ZG) is a modified formulation of Zhuhuang Decoction, which is used traditionally in China for the treatment of psoriasis in clinical practice. AIM OF THE STUDY: Recent studies have found that microRNAs (miRNAs) play important roles in the pathogenesis of some skin diseases...
August 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27551526/class-i-hdac-inhibitor-mocetinostat-induces-apoptosis-by-activation-of-mir-31-expression-and-suppression-of-e2f6
#17
Q Zhang, M Sun, S Zhou, B Guo
The class I selective inhibitor of the histone deacetylases, mocetinostat, has promising antitumor activities in both preclinical studies and the clinical trials. To understand how mocetinostat induces apoptosis, we examined the effects of mocetinostat on miR-31, a proapoptotic microRNA that was previously found to be epigenetically silenced in prostate cancer. We found that miR-31 was significantly upregulated by mocetinostat in prostate cancer cells. Antiapoptotic protein E2F6, the target of miR-31, was decreased by mocetinostat treatment...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27551310/circulating-micrornas-are-deregulated-in-overweight-obese-children-preliminary-results-of-the-i-family-study
#18
Giuseppe Iacomino, Paola Russo, Ilaria Stillitano, Fabio Lauria, Pasquale Marena, Wolfgang Ahrens, Pasquale De Luca, Alfonso Siani
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic disorders, including obesity. Recent studies showed remarkable stability of miRNAs in both plasma and serum making them suitable as potential circulating biomarkers for a variety of diseases and conditions. The aim of this study was to assess the profile of circulating miRNAs expressed in plasma samples of overweight or obese (OW/Ob) and normal weight (NW) prepubertal children from a European cohort (www...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27541266/reprogramming-of-normal-fibroblasts-into-cancer-associated-fibroblasts-by-mirnas-mediated-ccl2-vegfa-signaling
#19
Hua Shen, Xiaobo Yu, Fengming Yang, Zhihua Zhang, Jianxin Shen, Jin Sun, Swati Choksi, Siriporn Jitkaew, Yongqian Shu
Cancer-associated fibroblasts (CAFs), the most common constituent of the tumor stoma, are known to promote tumor initiation, progression and metastasis. However, the mechanism of how cancer cells transform normal fibroblasts (NFs) into CAFs is largely unknown. In this study, we determined the contribution of miRNAs in the transformation of NFs into CAFs. We found that miR-1 and miR-206 were down-regulated, whereas miR-31 was up-regulated in lung CAFs when compared with matched NFs. Importantly, modifying the expression of these three deregulated miRNAs induced a functional conversion of NFs into CAFs and vice versa...
August 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27528032/mir-31-targets-arid1a-and-enhances-the-oncogenicity-and-stemness-of-head-and-neck-squamous-cell-carcinoma
#20
Wen-Cheng Lu, Chung-Ji Liu, Hsi-Feng Tu, Yu-Tung Chung, Cheng-Chieh Yang, Shou-Yen Kao, Kuo-Wei Chang, Shu-Chun Lin
miR-31 is oncogenic for head and neck squamous cell carcinoma (HNSCC). Proteins containing the AT-rich interacting domain (ARID) modulate the accessibility of chromatin to the transcription machinery needed for gene expression. In this study, we showed that miR-31 was able to target ARID1A in HNSCC. HNSCC tumors had an inverse miR-31 and ARID1A expression. miR-31 associated oncogenicities were rescued by ARID1A expression in HNSCC cells. Furthermore, ARID1A repressed the stemness properties and transcriptional activity of Nanog/OCT4/Sox2/EpCAM via the protein's affinity for AT-rich sites within promoters...
August 9, 2016: Oncotarget
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