keyword
https://read.qxmd.com/read/37360090/circular-rna-circbnc2-facilitates-glycolysis-and-stemness-of-hepatocellular-carcinoma-through-the-mir-217-high-mobility-group-at-hook-2-hmga2-axis
#21
JOURNAL ARTICLE
Yan Feng, Shufeng Xia, Junlan Hui, Yan Xu
Hepatocellular cancer (HCC) accounts for approximately 90% of primary liver carcinoma and is a significant health threat worldwide. Circular RNA basonuclin 2 (circBNC2) is implicated with the progression of several cancers. However, its roles in carcinogenesis and glycolysis are still unclear in HCC. In this study, the levels of circBNC2 and high mobility group AT-hook 2 (HMGA2) were highly expressed, while these of miR-217 were poorly expressed in HCC tissues and cells. Upregulation of circBNC2 was related to poor prognosis and tumor node metastasis (TNM) stage...
June 2023: Heliyon
https://read.qxmd.com/read/37335318/retraction-note-to-mir-217-5p-inhibits-invasion-and-metastasis-of-prostate-cancer-by-targeting-clusterin
#22
Wanli Zhao, Xiuli Wang, Yuqing Jiang, Xiaopeng Jia, Yuexian Guo
No abstract text is available yet for this article.
June 19, 2023: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://read.qxmd.com/read/37239355/-coronin-1c-regulated-by-multiple-micrornas-facilitates-cancer-cell-aggressiveness-in-pancreatic-ductal-adenocarcinoma
#23
JOURNAL ARTICLE
Kosuke Fukuda, Naohiko Seki, Ryutaro Yasudome, Reiko Mitsueda, Shunichi Asai, Mayuko Kato, Tetsuya Idichi, Hiroshi Kurahara, Takao Ohtsuka
Coronin proteins are actin-related proteins containing WD repeat domains encoded by seven genes ( CORO1A , CORO1B , CORO1C , CORO2A , CORO2B , CORO6 , and CORO7 ) in the human genome. Analysis of large cohort data from The Cancer Genome Atlas revealed that expression of CORO1A , CORO1B , CORO1C , CORO2A , and CORO7 was significantly upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues ( p < 0.05). Moreover, high expression of CORO1C and CORO2A significantly predicted the 5 year survival rate of patients with PDAC ( p = 0...
April 27, 2023: Genes
https://read.qxmd.com/read/37183050/retraction-notice-to-mir-217-represses-tgf-%C3%AE-1-induced-airway-smooth-muscle-cell-proliferation-and-migration-through-targeting-zeb1-biomed-pharmacother-108-2018-27-35
#24
Ying Gao, Botao Wang, Huanan Luo, Qing Zhang, Min Xu
No abstract text is available yet for this article.
May 12, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37165403/mir-217-regulates-autophagy-through-opg-rankl-rank-in-giant-cell-tumors
#25
JOURNAL ARTICLE
Chenyang Meng, Boyong Jiang, Wanlin Liu, Lianjuan Wang, Zhenqun Zhao, Rui Bai, Yan Zhao
BACKGROUND: Increasing evidence suggests that microRNAs (miRNAs) play a crucial role in cancer development and progression. Our previous study showed remarkably lower levels of miR-217 in GCT cells and tissues, and miR-217 re-expression inhibited the occurrence and development of GCT in vitro; however, the associated mechanisms remain unknown. Thus, this study aimed to explore the mechanisms underlying the proliferation inhibitory effect of miR-217 in GCT cells. METHODS: The proliferative potential of the GCT cells was measured with an MTT assay and BrdU straining...
May 10, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/37094855/hsa_circ_0006916-exerts-effect-on-amyloid-beta-induced-neuron-injury-by-targeting-mir-217-homer1
#26
JOURNAL ARTICLE
Cheng Chen, Fan Fang
OBJECTIVE: Circular RNAs (circRNAs) are rich in miRNA-binding sites, which serve as miRNA sponges or competitive endogenous RNAs (ceRNAs). In the central nervous system, circRNAs are relevant to many neurological disorders including Alzheimer's disease (AD). Dementia associated with AD is correlated with the conversion of the β-Amyloid (Aβ) peptides from soluble monomers to aggregated oligomers and insoluble fibrils. Downregulation of circHOMER1 (circ_0006916) expression level is observed in AD female cases...
March 2023: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/37065602/snhg-12-and-hsa-mir-140-5p-may-play-an-important-role-in-the-cerna-network-related-to-hypertrophic-cardiomyopathy
#27
JOURNAL ARTICLE
Junyu Zhai, Fanli Guo, Xiaonan Zhou, Kai Zhu, Jun Li, Chunsheng Wang
BACKGROUND: Competing endogenous RNA (ceRNA) networks play important roles in the mechanism and development of a variety of diseases. This study aimed to construct a ceRNA network of hypertrophic cardiomyopathy (HCM). METHODS: We searched the Gene Expression Omnibus (GEO) database and then analyzed the RNAs of 353 samples to explore differentially expressed lncRNAs (DELs), microRNAs (miRNAs; DEMs), and messenger RNAs (DEmRNAs) during the progression of HCM. Weighted gene co-expression network analysis (WGCNA), Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and transcription factor (TF) prediction of miRNAs were also performed, and the GO terms, KEGG pathway terms, protein-protein interaction (PPI) network, and Pearson correlation network of the DEGs were visualized with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database and through Pearson analysis...
March 31, 2023: Journal of Thoracic Disease
https://read.qxmd.com/read/37034893/study-of-dach1-expression-and-its-epigenetic-regulators-as-possible-breast-cancer-related-biomarkers
#28
JOURNAL ARTICLE
Mohammad Hossein Nasirpour, Mahdieh Salimi, Faezeh Majidi, Zarrin Minuchehr, Hossein Mozdarani
BACKGROUND: Breast carcinogenesis involves both genetic and epigenetic changes. DNA methylation, as well as micro-RNA regulations, are the significant epigenetic phenomena dysregulated in breast cancer. Herein, the expression of DACH1 as a tumor suppressor gene and its promoter methylation status was analyzed in breast cancer tumors. Also, the expression of three micro RNAs (miR-217, miR-6807-3p, and miR-552), which had been previously reported to target DACH1 , was assessed. METHODS: The SYBR green-based Real-Time reverse transcription-PCR was used to determine DACH1 and micro-RNAs (miR-217, miR-6807-3p, and miR-552) expression in 120 ductal breast cancer tumors compared with standard control...
2023: Avicenna Journal of Medical Biotechnology
https://read.qxmd.com/read/36948260/myelin-basic-protein-recovery-during-pku-mice-lifespan-and-the-potential-role-of-micrornas-on-its-regulation
#29
JOURNAL ARTICLE
Alessandro Bregalda, Claudia Carducci, Maria Teresa Viscomi, Francesca Pierigè, Sara Biagiotti, Michele Menotta, Federica Biancucci, Tiziana Pascucci, Vincenzo Leuzzi, Mauro Magnani, Luigia Rossi
Untreated phenylketonuria (PKU) patients and PKU animal models show hypomyelination in the central nervous system and white matter damages, which are accompanied by myelin basic protein (MBP) impairment. Despite many assumptions, the primary explanation of the mentioned cerebral outcomes remains elusive. In this study, MBP protein and mRNA expression on brains of wild type (WT) and phenylketonuric (ENU2) mice were analyzed throughout mice lifespan (14-60-180-270-360-540 post-natal days, PND). The results confirmed the low MBP expression at first PND times, while revealed an unprecedented progressive MBP protein expression recovery in aged ENU2 mice...
March 21, 2023: Neurobiology of Disease
https://read.qxmd.com/read/36902565/a-3-mirna-risk-scoring-signature-in-early-diabetic-retinopathy
#30
JOURNAL ARTICLE
Jiali Wu, Ke Shi, Fang Zhang, Xiaodong Sun
PURPOSE: The aim of our study was to investigate a comprehensive profile of streptozotocin (STZ)-induced early diabetic retinopathy (DR) mice to identify a risk scoring signature based on micorRNAs (miRNAs) for early DR diagnosis. METHODS: RNA sequencing was performed to obtain the gene expression profile of retinal pigment epithelium (RPE) in early STZ-induced mice. Differentially expressed genes (DEGs) were determined with log2|fold change (FC)| > 1 and p value < 0...
February 23, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36835029/expression-of-selected-mirnas-in-normal-and-cancer-associated-fibroblasts-and-in-bxpc3-and-mia-paca-2-cell-lines-of-pancreatic-ductal-adenocarcinoma
#31
JOURNAL ARTICLE
Václav Mandys, Alexey Popov, Robert Gürlich, Jan Havránek, Lucie Pfeiferová, Michal Kolář, Jana Vránová, Karel Smetana, Lukáš Lacina, Pavol Szabo
Therapy for pancreatic ductal adenocarcinoma remains challenging, and the chances of a complete cure are very limited. As in other types of cancer, the expression and role of miRNAs in controlling the biological properties of this type of tumor have been extensively studied. A better insight into miRNA biology seems critical to refining diagnostics and improving their therapeutic potential. In this study, we focused on the expression of miR-21, -96, -196a, -210, and -217 in normal fibroblasts, cancer-associated fibroblasts prepared from a ductal adenocarcinoma of the pancreas, and pancreatic carcinoma cell lines...
February 10, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36824247/lncrna-neat1-regulates-th1-th2-in-pediatric-asthma-by-targeting-microrna-217-gata3
#32
JOURNAL ARTICLE
Xianpeng Yan, Hong Liu, Ting Li
BACKGROUND: The imbalance of immune response between helper Th1 and Th2 cells is the direct cause of asthma. It was closely related to abnormal expression of lncRNAs. However, whether lncRNAs can regulate Th1/Th2 balance in pediatric asthma remains to be investigated. METHODS: Peripheral blood samples were collected from children with asthma and normal volunteers at the Children's Hospital of Shaanxi Provincial People's Hospital (Xi'an, China) in 2020. The qRT-PCR was used to detect the expression of lncRNA NEAT1, miR-217 and GATA3 in peripheral blood samples...
January 2023: Iranian Journal of Public Health
https://read.qxmd.com/read/36804476/novel-splice-variants-of-linc00963-suppress-colorectal-cancer-cell-proliferation-via-mir-10a-mir-143-mir-217-mir-512-mediated-regulation-of-pi3k-akt-and-wnt-%C3%AE-catenin-signaling-pathways
#33
JOURNAL ARTICLE
Zahra Ghaemi, Seyed Javad Mowla, Bahram Mohammad Soltani
Emerging evidence has shown lncRNAs play important roles in signaling pathways involved in colorectal cancer (CRC) carcinogenesis. However, only a few functional lncRNAs have been extensively researched, especially in CRC-related signaling pathways. Looking for novel candidate regulators of CRC incidence and progression, using available RNA-seq and microarray datasets, LINC00963 was introduced as a bona fide oncogenic-lncRNA. Consistently, RT-qPCR results showed that LINC00963 was up-regulated in CRC tissues...
February 16, 2023: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
https://read.qxmd.com/read/36801468/mir-217-targets-tbk1-to-modulate-inflammatory-response-in-grass-carp-following-infection-with-aeromonas-hydrophila
#34
JOURNAL ARTICLE
Abdul-Razak Salifu, Yifan Pang, Yan He, Yang Liu, Yubang Shen, Xiaoyan Xu, Jiale Li
The current study demonstrated that miR-217 modulate inflammation in grass carp (Ctenopharyngodon Idella) infected with Aeromonas hydrophila. Bacterial infection in grass carp causes high level of septicemia which arises with systemic inflammatory responses. As a result leading to the development of hyper inflammatory state which causes septic shocks and lethality. Base on the current data, TBK1 was confirmed to be the target gene of miR-217 after a successful gene expression profiling experiment or luciferase experiment and miR-217 expression in CIK cells...
February 18, 2023: Developmental and Comparative Immunology
https://read.qxmd.com/read/36760350/emodin-regulates-lncrna-xist-mir-217-axis-to-protect-myocardial-ischemia-reperfusion-injury
#35
JOURNAL ARTICLE
Shuai Huang, Lailiang Xue, Qiaona Mou
PURPOSE: This study is aimed at investigating the effect of emodin on myocardial ischemia-reperfusion injury (MIRI) and mechanism. METHODS: Eighty healthy adult male SD rats (weighing 230-250 g) were utilized to establish I/R model, which were randomly divided into five groups (16 rats in each group): sham operation group, myocardial ischemia-reperfusion injury group (I/R group), emodin group, emodin +NC group, and emodin +XIST group. The contents of CK, CK-MB, LDH, and HBDH in serum were determined by ELISA kit...
2023: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/36733244/evaluation-of-serum-mir-216a-mir-216b-mir217-mir-92b-mir-375-and-mir-148a-as-potential-biomarkers-for-acute-pancreatitis-and-the-role-of-mir-92b-in-attenuating-caerulein-induced-injury-and-inflammatory-responses-in-ar42j-cells
#36
JOURNAL ARTICLE
Benshen Luo, Chen Wang, Zhengyu Wang, Chuanguo Chen, Xiaozhuang Peng, Qingchun Xu
BACKGROUND: Acute pancreatitis can eventually lead to morbidity and mortality. The present study aimed to identify the differentially expressed microRNAs (miRNAs) that are related to acute pancreatitis and explore the in vitro functional role of miR-92b in acute pancreatitis. METHODS: Bioinformatics analysis was used to identify differentially expressed miRNAs in caerulein-induced acute pancreatitis samples when compared to normal controls. The role of miR-92b in acute pancreatitis was examined by in vitro functional assays...
February 2, 2023: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/36577047/photobiomodulation-800%C3%A2-nm-light-emitting-diode-treatment-promotes-bone-mesenchymal-stem-cell-proliferation-via-long-noncoding-rna-meg3-microrna-217-5p-pathway
#37
JOURNAL ARTICLE
Na Liu, Lan Cao, Lei Peng, Weiwei Lu, Xiaolin Dai, Shengyu Wang, Guangqiong Guo, Xiaowen Qu, Ying Xu, Chongtao Zhu
Background: Patients with osteoporosis (OP) have a high risk of bone fracture. Abnormal bone mesenchymal stem cell (BMSC) differentiation is an essential process of OP development. In recent years, photobiomodulation has been shown to effectively promote BMSC proliferation. However, the mechanism by which photobiomodulation promotes BMSC proliferation is unclear. Long noncoding RNAs (lncRNAs) are essential mediators in multiple biological processes. The lncRNA maternally expressed gene 3 (MEG3) is a novel lncRNA gene and is related to cell proliferation...
December 27, 2022: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/36495416/construction-of-lentiviral-vector-for-mir-217-overexpression-and-knockdown-and-its-effect-on-cml
#38
JOURNAL ARTICLE
Xin Yang, Huihui Jiang, Chengming Sun
We attempted to construct a myeloid leukemia cell strain for stable overexpression and knock-down of miR-217 and explored the possible mechanism underlying miR-217 in chronic myeloid leukemia (CML). MiR-217 overexpression and the knock-down lentiviral vector with puromycin resistance were constructed and packaged within recombinant lentivirus. Stably transfected K562 cells were obtained through puromycin screening, and the qPCR assay detected the relative expression of the target gene. The proliferation, apoptosis, and methylation level of PER2 within cultured cells were detected using the CCK-8 assay, flow cytometry, and TaqMan real‑time fluorescence quantitative methylation-specific PCR...
December 10, 2022: Molecular Biotechnology
https://read.qxmd.com/read/36461670/bladder-cancer-tissue-derived-exosomes-suppress-ferroptosis-of-t24-bladder-cancer-cells-by-transporting-mir-217
#39
JOURNAL ARTICLE
Zhong-Ming Huang, Hai Wang, Zhi-Gang Ji
It has been reported that miR-217 can inhibit the oncogenic activity and progression of bladder cancer (BCa) cells, but it has not been explored whether miR-217 is involved in the regulation of ferroptosis. In the present study, RNA transfection, real-time PCR, flow cytometry, Western blotting assays, immunofluorescence and ELISA were performed to explore the effects and mechanisms of miR-217 in BCa tissue-derived exosomes. We found that extracellular fluid from bladder cancer tissue promoted the growth and miR-217 expression of T24 cells and inhibited ferroptosis...
December 2, 2022: Environmental and Molecular Mutagenesis
https://read.qxmd.com/read/36443856/epigenetic-modification-of-mir-217-promotes-intervertebral-disc-degeneration-by-targeting-the-fbxo21-erk-signalling-pathway
#40
JOURNAL ARTICLE
Zhonghui Chen, Jianghua Ming, Yajing Liu, Geliang Hu, Qi Liao
BACKGROUND: Numerous potential therapeutic alternatives for intervertebral disc degeneration (IDD) have been investigated, the most promising of which are based on biological variables such as microRNAs (miRNAs). Therefore, we verified the hypothesis that miRNAs modulate IDD by affecting the FBXO21-ERK signalling pathway. METHODS: Microarray and quantitative real-time polymerase chain reaction (RT-qPCR) tests were used to examine the expression profiles of miRNAs in nucleus pulposus (NP) cells between patients with IDD and controls...
November 28, 2022: Arthritis Research & Therapy
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