keyword
https://read.qxmd.com/read/38387897/-mir-217-targeting-pi3k-akt-pathway-enhances-sensitivity-of-adriamycin-to-acute-myeloid-leukemia
#1
JOURNAL ARTICLE
Ding-Yun Gan, Jun Wu, Man Zhou, Wan Chen, Wen Jiang
OBJECTIVE: To investigate the effects of miR-217 on proliferation and adriamycin sensitivity of acute myeloid leukemia (AML) cells. METHODS: The mimic NC and miR-217 mimic vectors were constructed and transfected into HL-60 cells, and transfection efficiency was detected by qPCR. The cells were treated with different concentrations of adriamycin for 24 h and 48 h. CCK-8 assay was used to detect the chemical sensitivity of adriamycin and screen the optimal concentration and time of adriamycin treatment...
February 2024: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/38373669/platelet-rich-plasma-derived-extracellular-vesicles-inhibit-nf-%C3%AE%C2%BAb-nlrp3-pathway-mediated-pyroptosis-in-intervertebral-disc-degeneration-via-the-malat1-microrna-217-sirt1-axis
#2
JOURNAL ARTICLE
Xueqiang Tao, Fen Xue, Jiayuan Xu, Wenbo Wang
BACKGROUND: Intervertebral disc degeneration (IDD) is a main contributor to lower back pain, and compression stress-induced apoptosis of nucleus pulposus (NP) cells and extracellular matrix (ECM) degradation has been implicated in the IDD progression. The functions of platelet-rich plasma (PRP)-derived extracellular vesicles (PRP-EVs) in regulating these biological processes remain unclear in IDD. Here, we aimed to investigate the key role of long noncoding RNA (lncRNA) MALAT1 incorporated in PRP-EVs in IDD...
February 17, 2024: Cellular Signalling
https://read.qxmd.com/read/38367931/quemeiteng-granule-relieves-goiter-by-suppressing-thyroid-microvascular-endothelial-cell-proliferation-and-angiogenesis-via-mir-217-5p-mediated-targeting-of-fgf2-induced-regulation-of-the-erk-pathway
#3
JOURNAL ARTICLE
Yang Li, Wen Yang, Xuewei Yang, Aijia Ma, Xuepeng Zhang, Hongxia Li, Hui Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Goiters are enlargements of the thyroid gland and are a global public issue. Quemeiteng granule (QMTG) is a traditional Chinese medicine (TCM) formula used to treat goiter in Yunnan Province. However, the effectiveness and underlying mechanism of these treatments have not been fully elucidated. AIM OF THE STUDY: This study aimed to investigate the therapeutic effects of QMTG on goiter and the downstream regulatory mechanisms. MATERIALS AND METHODS: In this study, we first evaluated the antigoiter efficacy of QMTG through biochemical indices [body weight, thyroid coefficient, triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH)] and hematoxylin-eosin (HE) staining in a Propylthiouracil (PTU)-induced model...
February 15, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38356866/lnc-ccnh-8-promotes-immune-escape-by-up-regulating-pd-l1-in-hepatocellular-carcinoma
#4
JOURNAL ARTICLE
Bixing Zhao, Xiaoyuan Zheng, Yang Wang, Niangmei Cheng, Yue Zhong, Yang Zhou, Jingyun Huang, Fei Wang, Xin Qi, Qiuyu Zhuang, Yingchao Wang, Xiaolong Liu
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis. In recent years, immune checkpoint inhibitors (ICIs) have enabled breakthroughs in the clinical treatment of patients with HCC, but the overall response rate to ICIs in HCC patients is still low, and no validated biomarker is available to guide clinical decision making. Here, we demonstrated that the long non-coding RNA Lnc-CCNH-8 is highly expressed in HCC and correlates with poor prognosis. Functionally, elevated Lnc-CCNH-8 inactivated co-cultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38296728/retraction-notice-to-mir-217-inhibits-proliferation-migration-and-invasion-via-targeting-akt3-in-thyroid-cancer-biomed-pharmacother-95-2017-1718-1724
#5
JOURNAL ARTICLE
Yuanqiang Lin, Kailiang Cheng, Tongtong Wang, Qian Xie, Minglong Chen, Qianqian Chen, Qiang Wen
No abstract text is available yet for this article.
January 30, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38236939/mir-217-regulates-normal-and-tumor-cell-fate-following-induction-of-endoplasmic-reticulum-stress
#6
JOURNAL ARTICLE
Neekkan Dey, Constantinos Koumenis, Davide Ruggero, Serge Y Fuchs, J Alan Diehl
Rapidly proliferating cancer cells must thrive in a microenvironment wherein metabolic nutrients such as glucose, oxygen and growth factors become limiting as tumor volume expands beyond the established vascularity of the tissue. Limits in nutrient availability typically trigger growth arrest and/or apoptosis to prevent cellular expansion. However, tumor cells frequently co-opt cellular survival pathways thereby favoring cell survival under this environmental stress. The Unfolded Protein Response (UPR) pathway is typically engaged by tumor cells to favor adaptation to stress...
January 18, 2024: Molecular Cancer Research: MCR
https://read.qxmd.com/read/38195397/serum-microrna-profiles-in-chronic-hepatitis-c-egyptian-patients-before-and-after-combined-sofosbuvir-and-daclatasvir-treatment
#7
JOURNAL ARTICLE
Wafaa M Ezzat, Khalda S Amr, Salwa Tawfeek, Hassan Elbatae, Eman A Bayomi, Ahmed Heiba, Yasser Elhosary
BACKGROUND: MicroRNAs (miR) are small sequence of nucleotides that can affect multiple genes involved in the hepatitis C virus (HCV) life cycle and disease development. The purpose of the present study was to investigate the clinical significance of serum microRNA profiles in a cohort of Egyptian patients with chronic HCV infection before and after combined sofosbuvir and daclatasvir treatment, as well as to gain a better understanding of the exact interaction mechanism in HCV transcriptional activity via differentially expressed miRNAs...
January 9, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38136977/mir-217-regulates-sirt1-expression-and-promotes-inflammatory-and-apoptotic-responses-in-osteoarthritis
#8
JOURNAL ARTICLE
Aliki-Alexandra Papageorgiou, Athanasios Roussos, Ioanna Papathanasiou, Charalampos Balis, Theophilos Karachalios, Sokratis E Varitimidis, Konstantinos N Malizos, Aspasia Tsezou
Previous studies have reported miR-217 uregulation in age-related pathologies. We investigated the impact of miR-217-5p on sirtuin 1 (SIRT1) regulation in human osteoarthritic (OA) chondrocytes. MiR-217 target enrichment analyses were performed using three public databases, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. MiR-217-5p expression levels were quantified in normal and OA chondrocytes. SIRT1 expression levels, nuclear factor kappa-B p65 subunit (NF-κBp65) and p53 acetylation levels, and expression levels of OA-related pro-inflammatory markers [tumor necrosis factor α (TNFα), interleukin 1β (IL-1β), IL-6], pro-apoptotic markers [Bax, pro-caspase 3, cleaved caspase 3] and matrix regulators [matrix metalloproteinase (MMP)-1, MMP-13, MMP-9, Collagen 2 (COL2A1), Aggrecan (ACAN)] were evaluated in miR-217 mimic-treated and/or miR-217 inhibitor-treated OA chondrocytes, with/without subsequent treatment with siRNA against SIRT1 (siSIRT1)...
November 29, 2023: Genes
https://read.qxmd.com/read/38131354/preparation-of-microgels-loaded-with-lycopene-nmn-and-their-protective-mechanism-against-acute-liver-injury
#9
JOURNAL ARTICLE
Jian Ge, Luting Ye, Min Cheng, Weijia Xu, Zhaowen Chen, Feng Guan
This study aimed to enhance the stability and bioavailability of lycopene (LYC) and nicotinamide mononucleotide (NMN) by incorporating them into porous microgels after loading LYC into liposomes. The particle size, zeta potential, encapsulation rate (%), scanning electron microscopy images, and stability and release kinetics characteristics in simulating digestion confirmed that the microgels had high LYC and NMN encapsulation rates (99.11% ± 0.12% and 68.98% ± 0.26%, respectively) and good stability and release characteristics...
December 22, 2023: Food & Function
https://read.qxmd.com/read/38125763/current-insights-into-the-oncogenic-roles-of-lncrna-linc00355
#10
REVIEW
Jinze Shen, Xinming Su, Ming Pan, Zehua Wang, Yufei Ke, Qurui Wang, Jingyin Dong, Shiwei Duan
Long noncoding RNAs (lncRNAs) are a class of nonprotein-coding transcripts that are longer than 200 nucleotides. LINC00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various cancers. It regulates the expression of downstream genes at both transcriptional and posttranscriptional levels, including eight microRNAs (miR-15a-5p, miR-34b-5p, miR-424-5p, miR-1225, miR-217-5p, miR-6777-3p, miR-195, and miR-466) and three protein-coding genes ( ITGA2 , RAD18 , and UBE3C ). LINC00355 plays a role in regulating various biological processes such as cell cycle progression, proliferation, apoptosis, epithelial-mesenchymal transition, invasion, and metastasis of cancer cells...
December 2023: Cancer Innov
https://read.qxmd.com/read/38071035/-effect-of-long-non-coding-rna-linc01268-on-the-malignant-biological-behaviors-of-acute-myeloid-leukemia-cells
#11
JOURNAL ARTICLE
Wan Chen, Ding-Yun Gan
OBJECTIVE: To investigate the effect of long non-coding RNA LINC01268 on apoptosis of acute myeloid leukemia (AML) cells and related mechanisms. METHODS: The expression levels of LINC01268 and miR-217 in peripheral blood samples from AML patients and AML cell lines HL-60 and KG-1 were detected by qRT-PCR. HL-60 cells were divided into pcDNA3.1-NC, pcDNA3.1-LINC01268, si-NC, si-LINC01268, miR-NC, miR-217 mimics, si-LINC01268 + inhibitor-NC and si-LINC01268+ miR-217 inhibitor groups...
December 2023: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/38029909/a-novel-lung-cancer-stem-cell-extracellular-vesicles-lncrna-rollcsc-modulate-non-stemness-cancer-cell-plasticity-through-mir-5623-3p-and-mir-217-5p-targeting-lipid-metabolism
#12
JOURNAL ARTICLE
Yu-Han Zhang, Yan Chen, Lei Shi, Xue Han, Jia-Cheng Xie, Yuting Chen, Meng Xiang, Bo-Wen Li, Jie Li, H Rosie Xing, Jian-Yu Wang
BACKGROUND: The high mortality rate of lung cancer is largely attributed to metastasis. Lung cancer stem cells (CSC) are conducive to cancer heterogeneity. Long noncoding RNAs are known to participate in various biological processes regulating the development of lung cancer. However, characterization of the role and mechanisms of lncRNA in lung cancer metastasis remains a challenge. RESULTS: We demonstrate that ROLLCSC, a highly expressed lncRNA in LLC-SDs, promotes the metastasis of the low metastatic LLCs both in vitro and in vivo...
November 27, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37890694/microrna-217-5p-triggers-dopaminergic-neuronal-degeneration-via-autophagy-activation-under-atrazine-exposure
#13
JOURNAL ARTICLE
Bingyun Li, Yujia Jiang, Ting Wang, Weiwei Liu, Xiaojuan Chen, Jinyi He, Zeyu Du, Ruijiao Yang, Danxiu Miao, Yanshu Li
Atrazine (ATR) is a widely used agricultural herbicide, and its accumulation in soil and water can cause various environmental health problems. ATR has neurotoxic effects on dopaminergic neurons, which can lead to a Parkinson's disease (PD)-like syndrome. Epigenetics regulates gene expression dynamically through DNA methylation, histone post-translational modification, microRNA (miRNA) interaction, and RNA methylation. MicroRNA (miRNA), representing one of the primary epigenetic mechanisms responsible for regulating gene expression, plays a crucial role in maintaining normal cellular function, while dysregulation of miRNA expression has been observed in PD...
October 25, 2023: Environmental Pollution
https://read.qxmd.com/read/37835681/bovine-c-x-c-motif-chemokine-ligand-14-expression-is-regulated-by-alternative-polyadenylation-and-micrornas
#14
JOURNAL ARTICLE
Wei Zhao, Xueyan Liu, Chengping Li, Xuyong Qin, Shizhong Ren, Shujun Cao, Guoli Zhou
Alternative polyadenylation (APA), including APA that occurs only in the 3' UTR (3' UTR-APA), is an important post-transcriptional regulatory mechanism that leads to distinct 3' UTRs for some genes, increasing the complexity of the transcriptome. The post-transcriptional events regulating the expression of bovine, the C-X-C motif chemokine ligand 14 (CXCL14) gene, remains largely unknown. Here, we find that the bovine CXCL14 gene produces two different lengths of mRNA isoforms due to 3' UTR-APA, and the short and long 3' UTR is 126 bp and 1155 bp, respectively...
September 30, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37811232/retracted-midazolam-suppresses-hepatocellular-carcinoma-cell-metastasis-and-enhances-apoptosis-by-elevating-mir-217
#15
Computational And Mathematical Methods In Medicine
[This retracts the article DOI: 10.1155/2022/2813521.].
2023: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/37778981/evaluation-of-circulating-mir-216a-and-mir-217-as-biomarkers-of-pancreatic-damage-in-the-l-arginine-induced-acute-pancreatitis-mouse-model
#16
JOURNAL ARTICLE
Seiichiro Kurashige, Naomi Matsutani, Toyohiko Aoki, Terutaka Kodama, Yasuteru Otagiri, Yuko Togashi
We investigated the usefulness of circulating miR-216a-5p and miR-217-5p that are pancreas-enriched micro RNAs (miRNAs) as biomarkers of acute pancreatic damage, and compared them with conventional pancreatic biomarkers in L-arginine-induced acute pancreatitis mouse model. As the results, amylase and lipase levels apparently increased and peaked on Day 3 when acute pancreatitis including acinar cell degeneration/necrosis and inflammatory cell infiltration reached its peak. In contrast, miR-216a-5p and miR-217-5p increased from Day 1 when histopathological findings in the acinar cells were limited to decreased zymogen granules, and the increases in ratios were much higher than those of amylase and lipase...
2023: Journal of Toxicological Sciences
https://read.qxmd.com/read/37626035/eif4a3-mediated-circ_0042881-activates-the-ras-pathway-via-mir-217-sos1-axis-to-facilitate-breast-cancer-progression
#17
JOURNAL ARTICLE
Chenxi Ju, Mingxia Zhou, Dan Du, Chang Wang, Jieqiong Yao, Hongle Li, Yang Luo, Fucheng He, Jing He
Breast cancer (BC) is one of the most frequent cancer-related deaths in women worldwide. Studies have shown the potential impact of circRNAs in multiple human tumorigeneses. Research on the vital signaling pathways and therapeutic targets of circRNAs is indispensable. Here, we aimed to investigate the clinical implications and underlying mechanisms of circ_0042881 in BC. RT-qPCR validated circ_0042881 was notably elevated in BC tissues and plasma, and closely associated with BC clinicopathological features...
August 25, 2023: Cell Death & Disease
https://read.qxmd.com/read/37492701/exosomal-lncrna-linc01268-promotes-pancreatic-cancer-progression-via-the-mir-217-kif2a-pi3k-akt-axis
#18
JOURNAL ARTICLE
Shanshan Liu, Yang Di, Qiuyue Li, Litian Chen, Yan Ma, Xiaomeng He, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu, Jin Wang
No abstract text is available yet for this article.
September 2023: Genes & Diseases
https://read.qxmd.com/read/37461019/chemotherapy-induced-exosomal-circbach1-promotes-breast-cancer-resistance-and-stemness-via-mir-217-g3bp2-signaling-pathway
#19
JOURNAL ARTICLE
Wenjie Xia, Wuzhen Chen, Chao Ni, Xuli Meng, Jun Wu, Qiong Yang, Hongchao Tang, Hongjun Yuan, Shan Fang
BACKGROUND: Chemoresistance involves metastasis and aggressiveness of breast cancer (BC). Chemotherapy-elicited exosomes have been reported to be associated with drug resistance and pro-metastatic capacity of BC cells. Non-coding RNAs (ncRNAs) are enriched in exosomes, which participated in generation, progression, and resistance of BC. However, the mechanism underlying the chemoresistance and metastasis in BC cells mediated by the BC-derived exosomal ncRNAs remained to be elucidated...
July 17, 2023: Breast Cancer Research: BCR
https://read.qxmd.com/read/37365645/metabolic-memory-in-diabetic-foot-syndrome-dfs-micro-rnas-single-nucleotide-polymorphisms-snps-frequency-and-their-relationship-with-indices-of-endothelial-function-and-adipo-inflammatory-dysfunction
#20
JOURNAL ARTICLE
Alessandro Del Cuore, Rosaria Maria Pipitone, Alessandra Casuccio, Marco Maria Mazzola, Maria Grazia Puleo, Gaetano Pacinella, Renata Riolo, Carlo Maida, Tiziana Di Chiara, Domenico Di Raimondo, Rossella Zito, Giulia Lupo, Luisa Agnello, Gabriele Di Maria, Marcello Ciaccio, Stefania Grimaudo, Antonino Tuttolomondo
BACKGROUND: Diabetic foot is a significant cause of morbidity in diabetic patients, with a rate that is approximately twice that of patients without foot ulcers. "Metabolic memory" represents the epigenetic changes induced by chronic hyperglycaemia, despite the correction of the glucose levels themselves. These epigenetic modifications appear to perpetuate the damage caused by persistently elevated glucose levels even in their absence, acting at various levels, mostly affecting the molecular processes of diabetic ulcer healing...
June 26, 2023: Cardiovascular Diabetology
keyword
keyword
29218
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.