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https://www.readbyqxmd.com/read/28642131/mir-217-suppresses-proliferation-and-promotes-apoptosis-in-cardiac-myxoma-by-targeting-interleukin-6
#1
Jing Zhang, Cui Wang, Huimin Xu
Cardiac myxoma (CM) is a prevalent primary cardiac tumor. miR-217 plays a vital role in tumorigenesis of various cancers, however, its role and underlying molecular mechanism in human CM remain poorly understood. Here, we reported that the expression of miR-217 was downregulated in CM tissues and inversely correlated with the expression of Interleukin-6 (IL-6) mRNA. Gain-of-function analysis indicated that overexpression of miR-217 inhibited the proliferation and promoted the apoptosis of the primary CM cells...
June 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28624807/regulation-of-actin-binding-protein-anln-by-antitumor-mir-217-inhibits-cancer-cell-aggressiveness-in-pancreatic-ductal-adenocarcinoma
#2
Tetsuya Idichi, Naohiko Seki, Hiroshi Kurahara, Keiichi Yonemori, Yusaku Osako, Takayuki Arai, Atsushi Okato, Yoshiaki Kita, Takaaki Arigami, Yuko Mataki, Yuko Kijima, Kosei Maemura, Shoji Natsugoe
Analysis of our microRNA (miRNA) expression signature of pancreatic ductal adenocarcinoma (PDAC) revealed that microRNA-217 (miR-217) was significantly reduced in cancer tissues. The aim of this study was to investigate the antitumor roles of miR-217 in PDAC cells and to identify miR-217-mediated molecular pathways involved in PDAC aggressiveness. The expression levels of miR-217 were significantly reduced in PDAC clinical specimens. Ectopic expression of miR-217 significantly suppressed cancer cell migration and invasion...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28602161/cytoprotective-effect-exerted-by-geraniin-in-hepg2-cells-is-through-microrna-mediated-regulation-of-bach-1-and-ho-1
#3
Hoda Aayadi, Smriti P K Mittal, Anjali Deshpande, Makarand Gore, Saroj S Ghaskadbi
Geraniin, a hydrolysable tannin, used in traditional medicine in Southeast Asia, is known to exhibit various biological activities. As an antioxidant it is known to up-regulate phase II enzyme Heme oxygenase-1 (HO-1). However its mechanism is not clearly understood. Nuclear factor erythroid-derived 2 related factor 2 (Nrf-2) is transcriptionally up-regulated by Extracellular signal-regulated kinase (ERK) 1/2 and retained in nucleus due to inactivated Glycogen synthase kinase 3 beta (GSK-3β). Geraniin additionally down-regulates expression of microRNA 217 and 377 (miR-217 and miR-377) which target HO-1 mRNA...
June 12, 2017: BMB Reports
https://www.readbyqxmd.com/read/28599501/microrna-217-inhibits-cell-proliferation-and-enhances-chemosensitivity-to-doxorubicin-in-acute-myeloid-leukemia-by-targeting-kras
#4
Yi Xiao, Taoran Deng, Changliang Su, Zhen Shang
Acute myeloid leukemia (AML) is a heterogeneous malignant disorder derived from the myeloid hematopoietic cells that accounts for ~80% of all adult acute leukemia. Numerous studies have shown that drug resistance not only exists against conventional chemotherapeutic drugs, but also limits the efficacy of new biological agents. Therefore, it is important to identify the mechanisms behind chemoresistance and seek therapeutic strategies to enhance efficacy in AML chemotherapy. MicroRNA (miR)-217 has been recognized as a tumor suppressor that is downregulated in various types of cancer, however the mechanisms behind the expression and function of miR-217 in AML have not yet been recognized...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28578521/mir-138-promotes-migration-and-tube-formation-of-human-cytomegalovirus-infected-endothelial-cells-through-the-sirt1-p-stat3-pathway
#5
Shanchao Zhang, Lei Liu, Ruijin Wang, Houzhen Tuo, Yanjun Guo, Li Yi, Dexin Wang, Jiawei Wang
Human cytomegalovirus (HCMV) has been reported to be linked to vascular disease through the induction of neovessel formation. We have previously reported that microRNA (miR)-217 and miR-199a-5p enhance endothelial angiogenesis via inhibition of sirtuin 1 (SIRT1) in HCMV-infected human umbilical vein endothelial cells (HUVECs). Here, we found that miR-138 also suppressed the expression of the SIRT1 protein and stimulated phosphorylation of signal transducer and activator of transcription 3 (p-STAT3). Moreover, the regulation of p-STAT3 expression mediated by SIRT1 was found to promote HCMV-induced angiogenesis...
June 3, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28548126/microrna-dysregulation-in-the-tumor-microenvironment-influences-the-phenotype-of-pancreatic-cancer
#6
Eva Karamitopoulou, Stefan Haemmig, Ulrich Baumgartner, Cornelia Schlup, Martin Wartenberg, Erik Vassella
Cellular interactions in the tumor microenvironment influence neoplastic progression in pancreatic ductal adenocarcinoma. One underlying mechanism is the induction of the prognostically unfavorable epithelial-mesenchymal-transition-like tumor budding. Our aim is to explore the expression of microRNAs implicated in the regulation of tumor budding focusing on the microenvironment of the invasive front. To this end, RNA from laser-capture-microdissected material of the main tumor, tumor buds, juxta-tumoral stroma, tumor-remote stroma, and non-neoplastic pancreatic parenchyma from pancreatic cancer cases with (n=7) and without (n=6) tumor budding was analyzed by qRT-PCR for the expression of a panel of miRNAs that are known to be implicated in the regulation of epithelial-mesenchymal transition, including miR-21, miR-183, miR-200b, miR-200c, miR-203, miR-205, miR-210, and miR-217...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28539816/hsa-mir-96-and-hsa-mir-217-expression-down-regulates-with-increasing-dysplasia-in-pancreatic-intraepithelial-neoplasias-and-intraductal-papillary-mucinous-neoplasms
#7
XiaoYan Chang, ChunKai Yu, Ji Li, Shuangni Yu, Jie Chen
AIM: To compare the clinicopathological features of pancreatic intraepithelial neoplasias (PanINs) and intraductal papillary mucinous neoplasms (IPMNs), and to investigate the role of hsa-miR-96 and hsa-miR-217 in these two lesions. Methods: Formalin-fixed paraffin-embedded pancreatic specimens were selected in this study, including 58 cases of pancreatic intraepithelial neoplasias (PanINs), 45 cases of pancreatic ductal adenocarcinomas (PDAs), and 57 cases of intraductal papillary mucinous neoplasms (IPMNs)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28523250/host-microrna-217-promotes-white-spot-syndrome-virus-infection-by-targeting-tube-in-the-chinese-mitten-crab-eriocheir-sinensis
#8
Ying Huang, Keke Han, Wen Wang, Qian Ren
MicroRNAs (miRNAs), a group of small molecule non-encoding RNAs, are key post-transcriptional regulators of gene expression that are implicated in many biological processes. In the current study, miR-217 from Eriocheir sinensis was selected for studying its roles during host-virus interaction. Overexpression or silencing of miR-217 led to considerable effects on white spot syndrome virus (WSSV) replication, implying that miR-217 played a positive role in WSSV infection. In insect High Five cells, miR-217 significantly inhibited Tube gene expression by binding to the 3'-untranslated region of the Tube...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28492542/lncrna-hotair-regulates-hif-1%C3%AE-axl-signaling-through-inhibition-of-mir-217-in-renal-cell-carcinoma
#9
Quan Hong, Ou Li, Wei Zheng, Wen-Zhen Xiao, Lu Zhang, Di Wu, Guang-Yan Cai, John Cijiang He, Xiang-Mei Chen
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that HOTAIR is involved in the proliferation and tumorigenesis of renal carcinoma cells, while microRNA (miR)-217 functions as a tumor suppressor in renal cell carcinoma (Rcc). However, the underlying molecular mechanism of HOTAIR in Rcc, especially in association with miR-217, has not been studied. In this study, we first demonstrated that HOTAIR expression was upregulated, which was correlated with tumor progression, and miR-217 downregulated in Rcc tissues and cells...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28490741/circulating-mirna-21-5p-as-a-diagnostic-biomarker-for-pancreatic-cancer-evidence-from-comprehensive-mirna-expression-profiling-analysis-and-clinical-validation
#10
Kai Qu, Xing Zhang, Ting Lin, Tian Liu, Zhixin Wang, Sushun Liu, Lei Zhou, Jichao Wei, Hulin Chang, Ke Li, Zheng Wang, Chang Liu, Zheng Wu
Pancreatic cancer (PC) is a highly fatal disease worldwide and is often misdiagnosed in its early stages. The exploration of novel non-invasive biomarkers will definitely benefit PC patients. Recently, circulating miRNAs in body fluids are emerging as non-invasive biomarkers for PC diagnosis. In this study, we first conducted comprehensive robust rank aggregation (RRA) analysis based on 21 published miRome profiling studies. We statistically identified and clinically validated a miRNA expression pattern in PC patients...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28487235/transcriptome-wide-analysis-of-micrornas-in-branchiostoma-belcheri-upon-vibrio-parahemolyticus-infection
#11
Ping Jin, Shengjie Li, Lianjie Sun, Caiyun Lv, Fei Ma
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that participate in diverse biological processes via regulating expressions of target genes at post-transcriptional level. Amphioxus, as modern survivor of an ancient chordate lineage, is a model organism for comparative genomics study. However, miRNAs involved in regulating immune responses in Branchiostoma belcheri are largely unclear. Here, we systematically investigated the microRNAs (miRNAs) involved in regulating immune responses in the cephalochordate amphioxus (Branchiostoma belcheri) through next-generation deep sequencing of amphioxus samples infected with Vibrio parahemolyticus...
May 6, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28485805/microrna-217-suppressed-epithelial-to-mesenchymal-transition-in-gastric-cancer-metastasis-through-targeting-ptpn14
#12
Y-P Liu, X-H Sun, X-L Cao, W-W Jiang, X-X Wang, Y-F Zhang, J-L Wang
OBJECTIVE: Gastric cancer (GC) is the third leading cause of cancer-related deaths while the mechanisms underlying its metastasis are not fully understood. In this study, we aimed to explore the relationship between miR-217 and GC metastasis. PATIENTS AND METHODS: We examined miR-217 level in gastric tumor tissues of 48 patients with GC and in cell lines including gastric mucosa epithelial cell line (GES-1), gastric cancer cell line (BGC-823), and gastric cancer cell line (SGC-7901)...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28472810/the-long-non-coding-rna-crnde-promotes-colorectal-carcinoma-progression-by-competitively-binding-mir-217-with-tcf7l2-and-enhancing-the-wnt-%C3%AE-catenin-signaling-pathway
#13
Bo Yu, Xuan Ye, Qiong Du, Bin Zhu, Qing Zhai, Xin-Xiang Li
BACKGROUND/AIMS: The long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) contributes to the proliferation and migration of tumors. However, its molecular mechanism underlying gastric cancer remains unknown. In the present study, we investigated whether CRNDE was involved in the development of colorectal cancer via the binding of microRNA (miR)-217 with transcription factor 7-like 2 (TCF7L2) to enhance the Wnt signaling pathway. METHODS: Quantitative polymerase chain reaction was used to detect CRNDE, miR-217 and TCF7L2 in colorectal cancer tissues and cells...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28437471/mir-217-inhibits-triple-negative-breast-cancer-cell-growth-migration-and-invasion-through-targeting-klf5
#14
Wenhui Zhou, Fangfang Song, Qiuju Wu, Rong Liu, Lulu Wang, Cuicui Liu, You Peng, Shuqin Mao, Jing Feng, Ceshi Chen
Triple negative breast cancer (TNBC) is one of the most aggressive breast cancers without effective targeted therapies. Numerous studies have implied that KLF5 plays an important roles in TNBC. How is KLF5 regulated by microRNAs has not been well studied. Here, we demonstrated that miR-217 down-regulates the expression of KLF5 and KLF5's downstream target gene FGF-BP and Cyclin D1 in TNBC cell lines HCC1806 and HCC1937. Consequently, miR-217 suppresses TNBC cell growth, migration, and invasion. MiR-217 suppresses TNBC, at least partially, through down-regulating the KLF5 expression...
2017: PloS One
https://www.readbyqxmd.com/read/28418924/rna-sequencing-analyses-reveal-novel-differentially-expressed-genes-and-pathways-in-pancreatic-cancer
#15
Yixiang Mao, Jianjun Shen, Yue Lu, Kevin Lin, Huamin Wang, Yanan Li, Ping Chang, Mary G Walker, Donghui Li
Gene expression microarrays have identified many tumor markers and therapeutic targets for pancreatic ductal adenocarcinoma (PDAC). However, microarray profilings have limited sensitivity and are prone to cross-hybridization between homologous DNA fragments. Here, we perform a transcriptome analysis of paired tumor and adjacent benign pancreatic tissues from 10 patients who underwent resection for PDAC. We identify a total of 2736 differentially expressed genes (DEGs) with false discovery rate less than 0.05, including 1554 upregulated, 1182 downregulated, and 6 microRNAs (miR-614, miR-217, miR-27b, miR-4451, miR-3609, and miR-612)...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28380423/microrna-217-modulates-human-skin-fibroblast-senescence-by-directly-targeting-dna-methyltransferase-1
#16
Ben Wang, Rui Du, Xiao Xiao, Zhi-Li Deng, Dan Jian, Hong-Fu Xie, Ji Li
DNA methyltransferase 1 (DNMT1) is a major epigenetic regulator associated with many biological processes. However, the roles and mechanisms of DNMT1 in skin aging are incompletely understood. Here we explored the role of DNMT1 in human skin fibroblasts senescence and its related regulatory mechanisms. DNMT1 expression decreased in passage-aged fibroblasts and DNMT1 silencing in young fibroblasts induced the senescence phenotype. MiR-217 is predicted to target DNMT1 mRNA and miR-217 expression increased in passage-aged fibroblasts...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28339007/mir%C3%A2-217-inhibits-osteogenic-differentiation-of-rat-bone-marrow%C3%A2-derived-mesenchymal-stem-cells-by-binding-to-runx2
#17
Yu-Long Zhu, Shui Wang, De-Gang Ding, Liang Xu, Hai-Tao Zhu
The elucidation of the underlying molecular mechanisms regulating the osteogenic differentiation of bone marrow‑derived mesenchymal stem cells (BMSCs) is of great importance in improving the treatment of bone‑associated diseases. MicroRNAs (miRNAs) have been proven to regulate the osteogenic differentiation of BMSCs. The present study investigated the role of miR‑217 in the osteogenic differentiation of rat BMSCs. It was observed that miR‑217 expression levels were downregulated during the process of osteogenic differentiation...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28337292/mir-217-promotes-cutaneous-squamous-cell-carcinoma-progression-by-targeting-ptrf
#18
Ming Bai, Mingzi Zhang, Fei Long, Nanze Yu, Ang Zeng, Xiaojun Wang
Increasing evidences have suggested that microRNAs (miRNAs) act a critical role in tumor initiation, progression and metastasis. Deregulated expression of miR-217 has been identified in various tumors. However, the expression and role of miR-217 in the development of cutaneous squamous cell carcinoma (cSCC) remain unclear. In our study, we showed that miR-217 expression was upregulated in the cSCC tissues compared to adjacent non-tumor samples. We also demonstrated that miR-217 expression was upregualted in the cSCCcSCC cell lines...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28219405/ttbk2-circular-rna-promotes-glioma-malignancy-by-regulating-mir-217-hnf1%C3%AE-derlin-1-pathway
#19
Jian Zheng, Xiaobai Liu, Yixue Xue, Wei Gong, Jun Ma, Zhuo Xi, Zhongyou Que, Yunhui Liu
BACKGROUND: Circular RNAs are a subgroup of non-coding RNAs and generated by a mammalian genome. Herein, the expression and function of circular RNA circ-TTBK2 were investigated in human glioma cells. METHODS: Fluorescence in situ hybridization and quantitative real-time PCR were conducted to profile the cell distribution and expression of circ-TTBK2 and microRNA-217 (miR-217) in glioma tissues and cells. Immunohistochemical and western blot were used to determine the expression of HNF1β and Derlin-1 in glioma tissues and cells...
February 20, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28184926/mir-217-suppresses-proliferation-migration-and-invasion-promoting-apoptosis-via-targeting-mtdh-in-hepatocellular-carcinoma
#20
Mao Zhang, Min Li, Na Li, Zilang Zhang, Ning Liu, Xiaoyu Han, Qincheng Liu, Caixian Liao
Hepatocellular carcinoma (HCC) has frequent incidence and the third highest mortality rate among cancers in the world. This study aimed to clarify the roles of miR-217 and metadherin (MTDH) in HCC. First, we identified that miR-217 expression was downregulated and MTDH expression was upregulated in the HCC tissues. Functional studies revealed that miR-217 negatively regulated MTDH expression via binding to the 3'-untranslated region of MTDH mRNA in the HCC cells. In our further studies, the miR-217 overexpression resulted in downregulation of MTDH expression in HCC cells...
March 2017: Oncology Reports
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