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triamcinolone long term effects

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https://www.readbyqxmd.com/read/28571271/evaluation-of-efficacy-of-1-curcuminoids-as-local-application-in-management-of-oral-lichen-planus-interventional-study
#1
Anju Elizabeth Thomas, Beena Varma, Seema Kurup, Renju Jose, Marina Lazar Chandy, Sreeja P Kumar, M S Aravind, Athira Aruna Ramadas
INTRODUCTION: Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disease affecting the oral cavity which has been associated with severe burning sensation which in turn affects the quality of life of the patients. Currently, the effective treatment of choice remains the use of corticosteroids. The chronicity and recalcitrant nature of the disease demand the long term use of these drugs with ensuing adverse effects. Turmeric and its active ingredient, "curcumin", have been found to have anti-inflammatory, antioxidant and anticancer properties...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28537690/effect-of-mitomycin-c-and-triamcinolone-on-preventing-urethral-strictures
#2
Omer Kurt, Fethullah Gevher, Cenk Murat Yazici, Mustafa Erboga, Mucahit Dogru, Cevat Aktas
Urethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28492586/-risk-of-pneumonia-during-long-term-regular-treatment-of-stable-copd-with-inhaled-glucocorticoids-a-systematic-review
#3
Fabio Arpinelli, Gaetano Caramori, Maria Sandra Magnoni
Inhaled glucocorticoids are anti-inflammatory drugs used in combination with long acting bronchodilators beta2-agonists for the treatment of stable chronic obstructive pulmonary disease (COPD), to improve lung function and symptoms and to reduce the future risk COPD exacerbations. However, has been also associated to an increased risk of pneumonia. The objective of this systematic review was therefore to analyze all randomized controlled trials to identify the risk of pneumonia during the regular treatment with long-term inhaled glucocorticosteroids compared to treatment with placebo in patients with stable COPD...
April 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28427069/practical-lessons-from-protocol-i-for-the-management-of-diabetic-macular-edema
#4
Lekha Mukkamala, Neelakshi Bhagat, Marco A Zarbin
Protocol I, a multicenter randomized clinical trial, compared the visual outcomes of patients treated with 0.5 mg intravitreal ranibizumab with either prompt or deferred (by 24 weeks laser), 4 mg intravitreal triamcinolone with prompt laser, or sham injection with prompt laser for the treatment of center-involving diabetic macular edema (DME). A total of 854 adult patients with type I or II diabetes and any level of non-proliferative diabetic retinopathy or proliferative retinopathy with adequate panretinal photocoagulation, with best-corrected visual acuity (BCVA) of 78 to 24 ETDRS letters (Snellen equivalent of 20/32 to 20/320) and visual loss attributed to macular edema, or retinal thickening with central subfield thickness of at least 250 µm by OCT were enrolled...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28427068/intravitreal-steroids-in-diabetic-macular-edema
#5
Rosangela Lattanzio, Maria Vittoria Cicinelli, Francesco Bandello
Over the past decade, great strides have been made in the management of diabetic macular edema (DME). Therapeutic alternatives now include focal/grid laser photocoagulation, vitreo-retinal surgery, and intraocular injection of anti-angiogenic and steroid molecules. Intravitreal administration of steroids represents a fundamental alternative for recalcitrant and naive eyes with DME, especially in those cases when anti-vascular endothelial growth factor (VEGF) agents are contraindicated or a treatment regimen with fewer intravitreal injections is required...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28427066/intravitreal-ranibizumab-in-diabetic-macular-edema-long-term-outcomes
#6
Ilaria Zucchiatti, Francesco Bandello
Intravitreal ranibizumab (RBZ) has been shown in multiple randomized clinical trials to be a valuable treatment for diabetic macular edema (DME), promoting a significant improvement in best-corrected visual acuity (BCVA) and in anatomic outcomes. Compared to sham (RISE and RIDE studies), RBZ rapidly and sustainably improved BCVA and decreased macular edema at 2 years, reducing the risk of further vision loss, with low rates of local or systemic side effects. Compared to macular laser photocoagulation (READ-2 study), RBZ provided a greater improvement in BCVA and regression in foveal thickness, but required a higher number of injections compared to patients treated with both RBZ and laser...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28396564/structural-analysis-of-the-glucocorticoid-receptor-ligand-binding-domain-in-complex-with-triamcinolone-acetonide-and-a-fragment-of-the-atypical-coregulator-small-heterodimer-partner
#7
Emily R Weikum, C Denise Okafor, Emma H D'Agostino, Jennifer K Colucci, Eric A Ortlund
The synthetic glucocorticoids (GCs) dexamethasone, mometasone furoate, and triamcinolone acetonide are pharmaceutical mainstays to treat chronic inflammatory diseases. These drugs bind to the glucocorticoid receptor (GR), a ligand-activated transcription factor and member of the nuclear receptor superfamily. The GR is widely recognized as a therapeutic target for its ability to counter proinflammatory signaling. Despite the popularity of GCs in the clinic, long-term use leads to numerous side effects, driving the need for new and improved drugs with less off-target pharmacology...
July 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28339446/pulsed-radiofrequency-ablation-of-pudendal-nerve-for-treatment-of-a-case-of-refractory-pelvic-pain
#8
Vadim Petrov-Kondratov, Avneesh Chhabra, Stephanie Jones
Pudendal neuralgia (PN) is a result of pudendal nerve entrapment or injury, also called "Alcock syndrome." Pain that develops is often chronic, and at times debilitating. If conservative measures fail, invasive treatment modalities can be considered. The goal of this case report is to add to a small body of literature that a pulsed radiofrequency (PRF) ablation can be effectively used to treat PN and to show that high resolution MR neurography imaging can be used to detect pudendal neuropathy. CASE PRESENTATION: We present a case of a 51-year-old woman with 5 years of worsening right groin and vulva pain...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28255227/five-year-outcomes-of-pars-plana-vitrectomy-for-macular-edema-associated-with-branch-retinal-vein-occlusion
#9
Akihiro Nishida, Hiroshi Kojima, Takanori Kameda, Michiko Mandai, Yasuo Kurimoto
PURPOSE: Long-term outcomes of pars plana vitrectomy (PPV) for macular edema (ME) associated with branch retinal vein occlusion (BRVO) have been previously reported, but the studies did not report the number of additional treatments after surgery. During 5 years of follow-up, we therefore investigated the efficacy and safety of PPV for BRVO and evaluated the incidence of additional treatments. METHODS: We retrospectively reviewed the medical records of 25 eyes of 24 patients who underwent PPV for ME associated with BRVO and were followed up for at least 5 years...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28254265/outcomes-of-pediatric-cataract-surgery-with-triamcinolone-assisted-vitrectomy
#10
Tzu-Hsun Tsai, Chia-Ying Tsai, Jehn-Yu Huang, Fung-Rong Hu
PURPOSE: To evaluate outcomes in pediatric patients undergoing lensectomy, posterior capsulotomy, and triamcinolone-assisted vitrectomy for congenital cataract. METHODS: This retrospective study included 34 patients younger than 72 months who underwent lensectomy, posterior capsulotomy, and triamcinolone-assisted vitrectomy with or without intraocular lens (IOL) implantation for cataract at the National Taiwan University Hospital from July 2006 to December 2012...
February 18, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28229457/randomized-controlled-trial-of-local-progesterone-vs-corticosteroid-injection-for-carpal-tunnel-syndrome
#11
S A Raeissadat, S Shahraeeni, L Sedighipour, B Vahdatpour
OBJECTIVES: A number of studies have demonstrated the neuroprotective effects of progesterone and its influence on the recovery after neural injury. Few studies investigated the efficacy of local progesterone in carpal tunnel syndrome. The objective of this study was to compare the long-term effects of progesterone vs corticosteroid local injections in patients with mild and moderate carpal tunnel syndrome. METHODS: In this randomized clinical trial, 78 patients with carpal tunnel syndrome were assigned to two groups...
February 22, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28198750/relentless-placoid-chorioretinitis-successful-long-term-treatment-with-intravitreal-triamcinolone
#12
Daniel B Roth, Sheila Ballintine, Dimosthenis Mantopoulos, Jonathan Prenner, Howard F Fine
PURPOSE: To report a case of relentless placoid chorioretinitis (ampiginous choroiditis) treated with intravitreal triamcinolone acetonide (IVTA). METHODS: Interventional case report. RESULTS: A 34-year-old pregnant woman with a history of poor visual acuity in her left eye, secondary to an undetermined cause, developed an acute painless central scotoma and blurred vision in the right eye. The examination revealed decreased visual acuity, active inflammatory placoid choroidal lesions in the posterior pole, and mid-periphery with sharp disk margins and normal-appearing vasculature...
February 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28183220/long-term-follow-up-of-dupuytren-disease-after-injection-of-triamcinolone-acetonide-in-chinese-patients-in-taiwan
#13
C-Y Yin, H-H M Yu, J-P Wang, Y-C Huang, T-F Huang, M-C Chang
Injection of triamcinolone acetonide is a non-operative treatment for early-stage Dupuytren disease in Caucasians, but its effectiveness in non-Caucasians is unclear. We report averaged 5-year follow-up results of 37 patients (49 affected hands) with early-stage Dupuytren disease for patients in Taiwan (non-Caucasian) who received a single dose of 5 mg triamcinolone acetonide injection into nodules monthly for 3 months. Using ultrasound, we recorded no progression of sizes of the modules following injection after 6 months...
February 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28158160/ultrasound-guided-block-of-the-suprascapular-nerve-in-breast-cancer-survivors-with-limited-shoulder-motion-case-series
#14
Sibel Caglar Okur, Ozden Ozyemisci-Taskiran, Yasemin Pekindogan, Murat Mert, Nil Syiner Caglar
BACKGROUND: Suprascapular nerve block is performed in the management of chronic shoulder pain and frozen shoulder. OBJECTIVE: To investigate the effects of ultrasound-guided suprascapular nerve block in restoration of shoulder motion in breast cancer survivors. STUDY DESIGN: A cohort study. SETTING: A training and research hospital, outpatient setting. METHODS: A total of 18 breast cancer survivors with limited shoulder motion, pain, and difficulty in positioning the upper extremity for radiation treatment following surgery were enrolled in this study...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/27746559/a-comparative-study-of-continuous-versus-pulsed-radiofrequency-discectomy-for-management-of-low-backache-prospective-randomized-double-blind-study
#15
Bhagya Ranjan Jena, Anil Paswan, Yashpal Singh, Sandeep Loha, Anil Prasad Singh, Virendra Rastogi
BACKGROUND: Radiofrequency (RF) is a minimally invasive target-selective technique that has been used with success for many years in the treatment of different pathologies, such as low back pain, trigeminal neuralgia, and others. AIM: The aim of this study is to compare different mode of RF - continuous RF (CRF) versus pulsed RF (PRF) along with steroid in the management of low back pain of discogenic origin. SETTING AND DESIGN: Prospective, randomized, double-blind trial...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27572327/a-double-blind-randomized-comparative-study-of-triamcinolone-hexacetonide-and-dexamethasone-intra-articular-injection-for-the-treatment-of-knee-joint-arthritis-in-rheumatoid-arthritis
#16
RANDOMIZED CONTROLLED TRIAL
Mehrzad Hajialilo, Amir Ghorbanihaghjo, Leyla Valaee, Sousan Kolahi, Naderh Rashtchizadeh, Maryam Bannazadeh Amirkhiz, Ida Malekmahdavi, Alireza Khabbazi
Intra-articular glucocorticoid (GC) injection has been used for more than half a century in the treatment of refractory synovitis in patients with rheumatoid arthritis (RA). There are limited data about the efficacy of intra-articular injection of various preparations of GCs on inflamed joint. The aim of this study was to compare the efficacy and side effects of intra-articular injection of dexamethasone (DEX) and triamcinolone hexacetonide (TH) in the treatment of knee joint arthritis in RA. In a double-blind randomized clinical trial, 70 patients with RA and knee joint arthritis were recruited to the study...
December 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27548310/transforaminal-epidural-steroid-injection-in-lumbar-spinal-stenosis-an-observational-study-with-two-year-follow-up
#17
Niel Davis, Patrick Hourigan, Andrew Clarke
BACKGROUND CONTEXT: Transforaminal epidural steroid injection (TFESI) is recognised as a treatment for symptomatic lumbar disc herniation, whilst surgical decompression is generally thought to be the most effective treatment option for lumbar spinal stenosis. There is little available literature examining the effect of TFESI on symptomatic lumbar spinal stenosis. PURPOSE: To evaluate the use of TFESI as an alternative to surgery in patients with symptomatic stenosis...
April 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27454640/effect-of-intraarticular-triamcinolone-acetonide-injection-for-wrist-pain-in-rheumatoid-arthritis-patients-a-statistical-investigation
#18
Akihiro Fukui, Hideki Yamada, Takashi Yoshii
BACKGROUND: A significant number of patients on long-term treatment and users of biologics complain of wrist pain due to synovial proliferation and arthropathic changes. Synovectomy or joint arthroplasty is often indicated for such patients, but many refuse surgery. For these patients triamcinolone acetonide was injected into the dorsum of the wrist, and evaluated the clinical benefit and safety of the wrist joint. METHODS: We injected triamcinolone acetonide into the dorsum of the wrist...
June 2016: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/27434188/corticosteroid-injections-for-adhesive-capsulitis-a-review
#19
Ryan C Xiao, Kempland C Walley, Joseph P DeAngelis, Arun J Ramappa
OBJECTIVE: Adhesive capsulitis is a self-limiting condition in a majority of patients and is often treated nonoperatively. However, symptoms may take 2 to 3 years to resolve fully. A small, but significant, portion of patients require surgical intervention. The purpose of this systematic review is to evaluate the efficacy of corticosteroid injections for the treatment of adhesive capsulitis (AC). DATA SOURCES: A review of articles indexed by the United States National Library of Medicine was conducted by querying the PubMed database for studies involving participants with AC, frozen shoulder, stiff shoulder, or painful shoulder...
May 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/27411649/systemic-absorption-of-0-1-triamcinolone-acetonide-as-topical-application-in-management-of-oral-lichen-planus
#20
Athira Aruna Ramadas, Renju Jose, S L Arathy, Seema Kurup, Marina Lazar Chandy, Sreeja P Kumar
CONTEXT: Topical corticosteroids are the treatment of choice for oral lichen planus (OLP) due to its potential anti-inflammatory effect. However, chronic nature of OLP often requires long-term and frequent applications, exposing patients to local and systemic side effects. AIM: To detect the systemic absorption of 0.1% triamcinolone acetonide (TAC) through the oral mucosa of patients with OLP. SUBJECTS AND METHODS: This was a pilot pharmacokinetic study carried out in the Department of Oral Medicine and Radiology in collaboration with the Department of Toxicology, over 10 months...
May 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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