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https://read.qxmd.com/read/38348458/ultrasound-guided-treatment-of-polycaprolactone-granuloma
#1
Jair Mauricio Cerón Bohórquez, Stella Desyatnikova
Foreign body granulomas associated with polycaprolactone (PCL) filler injections are rare, yet challenging to manage. Multiple management modalities have been described. Here, we present a literature review and describe a case of histologically confirmed PCL-related granuloma, treated using ultrasound-guided injections of triamcinolone, hyaluronidase, and 5-fluorouracil combined with oral prednisolone and doxycycline.
February 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38245690/predictive-factors-for-esophageal-stenosis-in-patients-receiving-prophylactic-steroid-therapy-after-endoscopic-submucosal-dissection-for-esophageal-squamous-cell-carcinoma
#2
JOURNAL ARTICLE
Junichi Mizuno, Yuji Urabe, Shiro Oka, Hirona Konishi, Kazuki Ishibashi, Motomitsu Fukuhara, Hidenori Tanaka, Akiyoshi Tsuboi, Ken Yamashita, Yuichi Hiyama, Takahiro Kotachi, Hidehiko Takigawa, Ryo Yuge, Toru Hiyama, Shinji Tanaka
BACKGROUND: Methods to prevent esophageal stenosis (ES) after endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma (ESCC) have received increasing attention. Although steroid administration is a prophylactic treatment, the risk factors for ES during prophylactic steroid therapy remain unknown. Therefore, this study aimed to retrospectively evaluate the risk factors for refractory ES in patients administered prophylactic steroids after ESD for ESCC...
January 20, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38050555/a-pharmacovigilance-study-of-drug-induced-glaucoma-utilizing-the-japanese-adverse-event-reporting-system
#3
JOURNAL ARTICLE
Mariko Kozaru, Tatsuya Iida, Keiko Hosohata
PURPOSE: Clinically, glaucoma is a serious problem because it is asymptomatic until a relatively late stage in most cases, which can lead to delays in the diagnosis and treatment of the disease. The purpose of this study was to clarify the rank-order of the association of glaucoma with the causative drugs using a spontaneous reporting system database. METHODS: Data were extracted from the Japanese Adverse Drug Event Report database of the Pharmaceuticals and Medical Devices Agency (Japan)...
2023: Clinical Ophthalmology
https://read.qxmd.com/read/38050527/the-management-of-oral-pemphigus-vulgaris-in-a-hypertensive-patient-a-case-report
#4
Rosalyn Lalremtluangi, Suwarna Dangore-Khasbage, Swapnil Mohod
Pemphigus vulgaris (PV) is a chronic autoimmune disorder that causes painful blisters on the skin and mucosa along with erosions due to intra-epithelial acantholysis. This acantholysis is mainly due to an immune reaction against desmoglein (an adhesion glycoprotein molecule) by IgG autoantibodies, which causes loss of cell-to-cell adhesion. The treatment consists of systemic corticosteroids such as tablet prednisolone along with topical steroids such as 0.1% triamcinolone paste. But steroids are known for their side effects, one of which is hypertension...
November 2023: Curēus
https://read.qxmd.com/read/38046989/idiopathic-granulomatous-orbital-inflammation-with-right-frontal-nerve-involvement-a-case-report
#5
James Pietris, Jessica Y Tong, Dinesh Selva
INTRODUCTION: Idiopathic granulomatous orbital inflammation is a rare subtype of orbital inflammatory disease, and frontal nerve involvement has not been previously described. CASE PRESENTATION: This is a case of a 75-year-old female who presented with a 4-week history of a right orbital mass, scalp dysaesthesia, and ptosis. Magnetic resonance imaging of the orbits confirmed a right supraorbital mass originating from the lacrimal gland with frontal nerve enlargement...
2023: Case Reports in Ophthalmology
https://read.qxmd.com/read/37992355/the-efficacy-and-adverse-effects-of-corticosteroid-pulse-therapy-in-alopecia-areata-a-review-article
#6
REVIEW
Fatemeh Rastaghi, Roxana Kaveh, Nazafarin Yazdanpanah, Akram Sadat Sahaf, Najmeh Ahramyanpour
INTRODUCTION: Alopecia areata (AA) is a common, non-scarring, autoimmune hair loss disorder, varying in severity from small round hairless patches to the total loss of scalp or body hair. As steroid pulse therapy outcomes for AA vary, this study aimed to review the related literature regarding the efficacy, relapse rates, side effects, and prognostic factors associated with the response to different pulse corticosteroid treatments. METHODS: We performed a literature search on August 29, 2022, to provide an overview of the efficacy of pulse steroid therapy in patients with AA...
October 1, 2023: Dermatology Practical & Conceptual
https://read.qxmd.com/read/37924260/systemic-therapy-for-lichen-sclerosus-a-systematic-review
#7
JOURNAL ARTICLE
Abby Hargis, Madeline Ngo, Christina N Kraus, Melissa Mauskar
BACKGROUND: Lichen sclerosus (LS) is a chronic, inflammatory process affecting predominantly anogenital skin, with extragenital involvement in up to 20% of cases. The mainstay of therapy for anogenital LS is topical immunosuppression. However, in treatment-refractory cases, severe, or hypertrophic disease, systemic modalities may be used. Currently, there are no guidelines for systemic therapy in LS. OBJECTIVE: This study aimed to provide a review of the current literature on use of systemic therapies for LS, including demographic and clinical features of LS, as well as reported outcomes...
November 4, 2023: Journal of Lower Genital Tract Disease
https://read.qxmd.com/read/37870096/treatments-for-alopecia-areata-a-network-meta-analysis
#8
REVIEW
Miriam Mateos-Haro, Monica Novoa-Candia, Guillermo Sánchez Vanegas, Andrea Correa-Pérez, Andrea Gaetano Gil, Silvia Fernández-García, Daniel Ortega-Quijano, Mayra Gizeth Urueña Rodriguez, David Saceda-Corralo, Tayeb Bennouna-Dalero, Lucia Giraldo, Jaqueline Tomlinson, Sergio Vaño-Galván, Javier Zamora
BACKGROUND: Alopecia areata is an autoimmune disease leading to nonscarring hair loss on the scalp or body. There are different treatments including immunosuppressants, hair growth stimulants, and contact immunotherapy. OBJECTIVES: To assess the benefits and harms of the treatments for alopecia areata (AA), alopecia totalis (AT), and alopecia universalis (AU) in children and adults. SEARCH METHODS: The Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, ClinicalTrials...
October 23, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37450640/suprachoroidal-triamcinolone-injection-in-posterior-scleritis-a-case-report
#9
JOURNAL ARTICLE
Ploysai Rujkorakarn, Avery Zhou, Fatima Babiker, Peter Y Chang
Suprachoroidal triamcinolone acetonide (SCS-TA) injections were recently approved to treat macular edema secondary to noninfectious uveitis. However, its use in managing posterior scleritis has not been reported. We report the first case of SCS-TA used in the treatment of posterior scleritis. A 67-year-old woman with posterior scleritis complicated by exudative retinal detachment, diagnosed by spectral-domain optical coherence tomography scan (OCT), presented with pain, decreased vision, and redness in the left eye for 8 months...
July 14, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37288240/modified-two-stage-approach-for-management-of-combined-rhegmatogenous-retinal-detachment-and-choroidal-detachment-with-extreme-hypotony
#10
Vinita Gupta, Sandhya Makhija, Neelam Khatwani, Saurabh Luthra
Combined rhegmatogenous retinal detachment (RRD) and serous choroidal detachment (CD) present a significant challenge. No global standard of care exists for treating these complex RRDs. There is a lower failure rate when such detachments are treated with pars plana vitrectomy than with scleral buckle alone. The use of pre-operative steroids may not work in cases with moderate-to-severe CDs with severe hypotony where suprachoroidal fluid drainage is required to reduce inflammatory mediators, thus preventing proliferative vitreoretinopathy (PVR)...
May 2023: Curēus
https://read.qxmd.com/read/36818144/outcome-of-nivolumab-induced-vogt-koyanagi-harada-disease-like-uveitis-in-a-patient-managed-without-intravenous-methylprednisolone-therapy
#11
Ryoji Nagai, Akinari Yamamoto, Akiko Yoshida, Akiko Mikawa
BACKGROUND: In recent years, immune checkpoint inhibitors (ICI) have been often used for several types of cancers. Immune-related adverse events (irAEs) are autoimmune responses caused by ICI. Among the different types of irAEs, uveitis is common in ophthalmology. Moreover, there are reports on Vogt-Koyanagi-Harada (VKH) disease-like uveitis. In most cases, VKH, as in the usual VKH, is managed with intravenous methylprednisolone therapy. Case Report . A 72-year-old man was diagnosed with gastric cancer, and he was treated with nivolumab, a type of ICI...
2023: Case Reports in Ophthalmological Medicine
https://read.qxmd.com/read/36569015/systemic-combined-with-intravitreal-methotrexate-for-relentless-placoid-chorioretinitis-a-case-report
#12
Lan Luo, Wei-Bin Chen, Ming-Wei Zhao, Heng Miao
BACKGROUND: We describe a case of relentless placoid chorioretinitis (RPC) that progressed despite administration of peribulbar and systemic corticosteroids, and was resolved by systemic combined with intravitreal methotrexate. CASE SUMMARY: A 16-year-old male reported painless blurred vision and a temporal scotoma in his right eye for one week. Due to widespread distribution and continuous enlargement, multimodal imaging of the lesions led to the diagnosis of RPC...
December 16, 2022: World Journal of Clinical Cases
https://read.qxmd.com/read/36295627/use-of-ultra-widefield-fluorescein-angiography-to-guide-the-treatment-to-idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-case-report-and-literature-review
#13
REVIEW
Ping-Ping Meng, Chun-Ju Lin, Ning-Yi Hsia, Chun-Ting Lai, Henry Bair, Jane-Ming Lin, Wen-Lu Chen, Yi-Yu Tsai
PURPOSE: To review the clinical features, diagnosis, and treatment of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) and to report a case with the use of ultra-widefield fluorescein angiography (UWFA) for confirming the precise staging of IRVAN and aid in early treatment. The patient improved after being treated with intravitreal aflibercept injection. RESULTS: A 26-year-old female complained of progressive blurred vision OD for one week. Her BCVA was 0...
October 16, 2022: Medicina
https://read.qxmd.com/read/35728984/comparative-efficacy-and-safety-of-different-corticosteroids-to-reduce-inflammatory-complications-after-mandibular-third-molar-surgery-a-systematic-review-and-network-meta-analysis
#14
REVIEW
João Vitor Dos Santos Canellas, Fabio Gamboa Ritto, Paul Tiwana
A variety of corticosteroids are available as an alternative to reduce inflammatory complications after mandibular third molar surgery (3MS). However, it is unclear which are the best preoperative drugs, doses, and routes of administration. A frequentist network meta-analysis was performed to assess the comparative effectiveness of corticosteroids to reduce inflammatory complications after 3MS. We searched Embase, PubMed, and the Cochrane Library without language restrictions. Only randomised clinical trials (RCTs) were included...
October 2022: British Journal of Oral & Maxillofacial Surgery
https://read.qxmd.com/read/34278048/bilateral-infectious-scleritis-from-histoplasma-capsulatum-in-an-immunosuppressed-uveitis-patient
#15
Kevin Wang, Jordan D Deaner, Austen Knapp, Kimberly Baynes, Sunil K Srivastava
Purpose: To describe a case of bilateral infectious scleritis secondary to Histoplasma capsulatum in the setting of a locally and systemically immunosuppressed patient. Observations: A 45-year-old man with HLA-B27 associated ankylosing spondylitis and anterior uveitis on systemic secokinumab, underwent bilateral cataract extraction which required extensive peri-operative steroids, including intravitreal triamcinolone, topical prednisolone, and oral prednisone. Six weeks after cataract surgery, the patient presented with mild eye irritation and was found to have bilateral subconjunctival purulence and necrosis...
September 2021: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/34275660/a-systematic-review-and-meta-analysis-of-adjuncts-to-minimally-invasive-treatment-of-urethral-stricture-in-men
#16
JOURNAL ARTICLE
Karl H Pang, Christopher R Chapple, Robin Chatters, Alison P Downey, Christopher K Harding, Daniel Hind, Nick Watkin, Nadir I Osman
CONTEXT: Urethral stricture disease (USD) is initially managed with minimally invasive techniques such as urethrotomy and urethral dilatation. Minimally invasive techniques are associated with a high recurrence rate, especially in recurrent USD. Adjunctive measures, such as local drug injection, have been used in an attempt to reduce recurrence rates. OBJECTIVE: To systematically review evidence for the efficacy and safety of adjuncts used alongside minimally invasive treatment of USD...
October 2021: European Urology
https://read.qxmd.com/read/33618590/idiopathic-lipogranulomatous-orbital-inflammation-a-case-report-and-literature-review
#17
REVIEW
Sonia Huang, Luzern Tan, Valerie Juniat, Craig James, Dinesh Selva
A 57-year old woman presented with a 6-month history of a left red eye associated with diplopia. Examination was remarkable for 2 mm left-sided axial proptosis and restriction on left upgaze and abduction associated with diplopia. She had no previous history of trauma or surgery to the face. Magnetic resonance imaging revealed an enhancing infiltrative mass in the left intraconal space. Biopsy of the anterior orbital fat revealed extensive lipogranulomatous inflammation with no abnormalities noted on flow cytometry, culture, or special stains...
August 2022: Orbit
https://read.qxmd.com/read/33543352/three-cases-of-brolucizumab-associated-retinal-vasculitis-treated-with-systemic-and-local-steroid-therapy
#18
JOURNAL ARTICLE
Keiko Kataoka, Etsuyo Horiguchi, Kenichi Kawano, Hiroaki Ushida, Yuyako Nakano, Yasuki Ito, Hiroko Terasaki
PURPOSE: To describe three Japanese cases of retinal vasculitis that occurred following intravitreal brolucizumab injections and the systemic and local steroid treatment administered. CASES: Three patients developed intraocular inflammation (IOI) and retinal vasculitis following the first injection of brolucizumab for age-related macular degeneration. For two eyes, monthly aflibercept injections did not control exudation, and therapy was changed to brolucizumab; one eye was treatment-naïve...
March 2021: Japanese Journal of Ophthalmology
https://read.qxmd.com/read/33541774/care-and-treatment-of-peristomal-gangrenous-pyoderma-a-study-of-three-cases
#19
JOURNAL ARTICLE
Leticia Julve-Herraiz, Francisco Villalba-Ferrer, María José García-Coret, Blai García-Costa
Peristomal gangrenous pyoderma is an inflammatory skin disease with progression to painful ulcer, rare, and rarely associated with colorectal carcinoma. Its diagnosis is differential since it can be confused with skin infection, abscess, contact dermatitis, peristomal irritation or peristomal skin extension of an inflammatory bowel disease. We present three cases of patients operated for colorectal carcinoma with an intestinal stoma, who developed peristomal gangrenous pyoderma. A plan of local care and dressings was developed using the NANDA, NOC and NIC taxonomies...
2021: Enfermería clínica (English Edition)
https://read.qxmd.com/read/33294727/brolucizumab-related-retinal-vasculitis-with-exacerbation-following-ranibizumab-retreatment-a-clinicopathologic-case-study
#20
Prashanth G Iyer, Marc C Peden, Ivan J Suñer, Nish Patel, Sander R Dubovy, Thomas A Albini
PURPOSE: To describe the clinical and pathologic characteristics of a case of retinal vasculitis and vitritis following brolucizumab administration and subsequent ranibizumab treatment. OBSERVATIONS: A 76-year old Caucasian woman experienced pain, decreased vision and floaters one week after receiving her third monthly intravitreal brolucizumab injection in the right eye for exudative age-related macular degeneration. Examination was significant for 0.5+ anterior chamber cells, vitritis, mild peripheral vascular sheathing, and decreased vision from 20/70 to 20/200...
December 2020: American Journal of Ophthalmology Case Reports
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