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https://www.readbyqxmd.com/read/28731820/uncommon-neoplasms-of-the-biliary-tract-radiological-findings
#1
Vincenza Granata, Roberta Fusco, Orlando Catalano, Salvatore Filice, Antonio Avallone, Mauro Piccirillo, Maddalena Leongito, Raffaele Palaia, Roberto Grassi, Francesco Izzo, Antonella Petrillo
OBJECTIVES: To report our cancer center experience in the biliary tumors incidence other than cholangiocellular-carcinoma (CCC), emphasizing the radiological features. METHODS: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site, and signal intensity of lesions on MRI. Enhancement-pattern during the arterial-, portal-, and late-phase on US, CT and MR study was assessed as well as the enhancement pattern during the hepatobiliary-phase on MRI...
July 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28729631/therapeutic-effects-of-long-circulating-mir-135a-containing-cationic-immunoliposomes-against-gallbladder-carcinoma
#2
Guanghua Yang, Baobing Yin
Gallbladder carcinoma (GBC) is the most common malignant tumour in the biliary tract, but effective therapeutics are lacking. Based on our previous studies, miR-135a is a potential tool to inhibit GBC proliferation. In this study, we constructed miR-135a-loaded DSPE-PEG2000 liposomes modified with Anti-EGFR antibodies (Anti-EGFR-CIL-miR-135a). The results of an analysis of their physicochemical properties indicated the particle size of it was 222.0 ± 2.1 nm in diameter with an uptake efficiency of 86...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727952/time-resolved-laser-induced-fluorescence-spectroscopy-as-a-guidance-tool-for-laser-lithotripsy-of-gallbladder-stones
#3
Ali Shuaib, Jahja Kokaj, Yacoub Makdisi, Goran Pichler, Abdullah Husain, Sami Asfar
BACKGROUND AND OBJECTIVES: Although laser lithotripsy for fragmentation of gallbladder stones has been applied successfully in many clinical situations, this approach has two major limitations: (1) the potential to damage or perforate the bile duct and (2) the efficiency can be affected by the chemical composition of the gallstones. The present study evaluated the use of time-resolved laser-induced fluorescence spectroscopy to classify stone types and distinguish stone from tissue. MATERIALS AND METHODS: Ex vivo time-resolved laser-induced fluorescence analysis (excitation wavelength λex = 400 nm and emission wavelength = 450-700 nm) of 54 gallbladder stones and seven gallbladder tissue samples was conducted...
July 19, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28723805/acute-pancreatitis-induced-by-etoposide-lobaplatin-combination-chemotherapy-used-for-the-treatment-of-lung-cancer-a-case-report-and-literature-review
#4
Cheng-Liang Cao, Peng-Yu Duan, Wang-Jun Zhang, Le Li, Feng-Zhi Qu, Bei Sun, Gang Wang
RATIONALE: Drug-induced pancreatitis (DIP) is a rare type of pancreatitis that is not usually observed in the clinical practice. It is generally difficult to distinguish from acute pancreatitis (AP) induced by other causes. PATIENT CONCERNS: Here, we report a 62-year-old Chinese female patient with "small cell lung cancer" as the initial presentation. Because the patient could not bear the surgical treatment, the chemotherapy composed of lobaplatin and etoposide was performed...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722661/dck-expression-a-potential-predictive-biomarker-in-the-adjuvant-gemcitabine-chemotherapy-for-biliary-tract-cancer-after-surgical-resection-results-from-a-phase-ii-study
#5
Sang Myung Woo, Kyong-Ah Yoon, Eun Kyung Hong, Weon Seo Park, Sung-Sik Han, Sang-Jae Park, Jungnam Joo, Eun Young Park, Ju Hee Lee, Yun-Hee Kim, Tae Hyun Kim, Woo Jin Lee
The role of adjuvant therapy following resection of biliary tract cancer (BTC) remains unclear. We therefore evaluated the feasibility and toxicity of adjuvant gemcitabine in patients with BTC. This clinical phase II trial was an open-label, single center, single-arm study. Within 8 weeks after gross complete resection of BTC, patients were started on intravenous infusions of gemcitabine 1000 mg/m2 over 30 min on days 1, 8, and 15 of every 28-day cycle. Intratumoral expression of cytidine deaminase (CDA), human equilibrative transporter-1 (hENT1), deoxycytidine kinase (dCK) and ribonucleotide reductase subunit 1 (RRM1) was measured by immunohistochemistry...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28717913/survival-benefits-of-surgical-resection-in-patients-with-recurrent-biliary-tract-carcinoma
#6
Hiroaki Motoyama, Akira Kobayashi, Takahide Yokoyama, Akira Shimizu, Noriyuki Kitagawa, Tsuyoshi Notake, Kentaro Fukushima, Hitoshi Masuo, Takahiro Yoshizawa, Shin-Ichi Miyagawa
BACKGROUND: Whether surgical resection for recurrent biliary tract carcinoma (BTC) prolongs survival and the patients who are most likely to benefit from such treatment remain unclear. METHODS: Among 251 patients with recurrences after the initial resection of BTC, a total of 21 patients (8.4%) underwent surgical resection for the recurrence, with a zero mortality rate. The clinicopathological features of these patients were compared with those of patients who did not undergo surgery...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28710747/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-treating-her2-positive-advanced-biliary-tract-cancers-and-pancreatic-cancers
#7
Kaichao Feng, Yang Liu, Yelei Guo, Jingdan Qiu, Zhiqiang Wu, Hanren Dai, Qingming Yang, Yao Wang, Weidong Han
This phase I clinical trial (NCT01935843) is to evaluate the safety, feasibility, and activity of chimeric antigen receptor-engineered T cell (CART) immunotherapy targeting human epidermal growth factor receptor 2 (HER2) in patients with advanced biliary tract cancers (BTCs) and pancreatic cancers (PCs). Eligible patients with HER2-positive (>50%) BTCs and PCs were enrolled in the trial. Well cultured CART-HER2 cells were infused following the conditioning treatment composed of nab-paclitaxel (100-200 mg/m(2)) and cyclophosphamide (15-35 mg/kg)...
July 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28709465/subclinical-focal-cholangitis-mimicking-liver-metastasis-in-asymptomatic-patients-with-history-of-pancreatic-ductal-adenocarcinoma-and-biliary-tree-intervention
#8
Natally Horvat, Edmund M Godfrey, Timothy J Sadler, Jaclyn F Hechtman, Laura H Tang, Carlie S Sigel, Serena Monti, Lorenzo Mannelli
BACKGROUND: Cholangitis is an inflammatory process of the biliary tract with a wide range of clinical manifestations and it is not always considered in the differential diagnosis in asymptomatic patients. To the best of our knowledge there is no previous report in the English literature of focal cholangitis manifesting exclusively as liver parenchymal changes mimicking liver metastasis in asymptomatic patients with pancreatic ductal adenocarcinoma (PDAC) and history of manipulation of the biliary tree...
July 14, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28708225/clinical-outcomes-of-salvage-chemoradiotherapy-for-locally-recurrent-biliary-tract-cancer
#9
Jeong Il Yu, Hee Chul Park, Do Hoon Lim, Joon Oh Park, Young Suk Park, Seung Tae Kim, Seong Ho Choi, Dong Wook Choi, In Woong Han, Jin Seok Heo
PURPOSE: The purpose of this study was to investigate the clinical outcomes and prognostic factors of concurrent chemoradiotherapy (CCRT) for locally recurrent biliary tract cancer (BTC) after curative surgical resection. METHODS: We performed a retrospective cohort study of patients with locally recurrent BTC treated with CCRT between October 2004 and December 2013. The study included and analyzed 42 patients with a history of curative-intent surgical resection of confirmed adenocarcinoma originating from the biliary tract...
July 11, 2017: Tumori
https://www.readbyqxmd.com/read/28702164/a-case-of-an-anomalous-biliary-tract-diagnosed-preoperatively
#10
Jun Kataoka, Toshikatsu Nitta, Yoshihiro Inoue, Masato Ota, Tomo Tominaga, Kensuke Fujii, Hiroshi Kawasaki, Takashi Ishibashi
We describe a 48-year-old man with cholecystolithiasis whose preoperative magnetic resonance cholangiopancreatography (MRCP) scan showed that the right accessory hepatic duct branching from the cystic duct dominated an anterior segment of the right hepatic lobe. We observed the right accessory hepatic duct using intraoperative cholangiography, and we were able to perform laparoscopic cholecystectomy without injuring it. He had no complication after discharge, and a drip-infusion cholangiography-computed tomography (DIC-CT) scan demonstrated that the right accessory hepatic duct was intact, and it dominated an anterior segment of the right hepatic lobe...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28701572/clinical-application-of-targeted-deep-sequencing-in-solid-cancer-patients-utility-of-targeted-deep-sequencing-for-biomarker-selected-clinical-trial
#11
Seung Tae Kim, Kyoung-Mee Kim, Nayoung K D Kim, Joon Oh Park, Soomin Ahn, Jae-Won Yun, Kyu-Tae Kim, Se Hoon Park, Peter J Park, Hee Cheol Kim, Tae Sung Sohn, Dong Il Choi, Jong Ho Cho, Jin Seok Heo, Wooil Kwon, Hyuk Lee, Byung-Hoon Min, Sung No Hong, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Woong-Yang Park, Jeeyun Lee
Molecular profiling of actionable mutations in refractory cancer patients has the potential to enable "precision medicine," wherein individualized therapies are guided based on genomic profiling. The molecular-screening program was intended to route participants to different candidate drugs in trials based on clinical-sequencing reports. In this screening program, we used a custom target-enrichment panel consisting of cancer-related genes to interrogate single-nucleotide variants, insertions and deletions, copy number variants, and a subset of gene fusions...
July 12, 2017: Oncologist
https://www.readbyqxmd.com/read/28695669/risk-estimation-for-biliary-tract-cancer-development-and-validation-of-a-prognostic-score
#12
Nora Schweitzer, Mareike Fischer, Martha M Kirstein, Sarah Berhane, Martina Kottas, Marianne Sinn, Maria A Gonzalez-Carmona, Zeynep Balta, Tobias J Weismüller, Christian P Strassburg, Tanja Reineke-Plaaß, Hüseyin Bektas, Michael P Manns, Philip Johnson, Arndt Weinmann, Arndt Vogel
BACKGROUND & AIMS: Biliary tract cancer is a rare tumor entity characterized by a poor prognosis. We aimed to identify prognostic factors and create a prognostic score to estimate survival. METHODS: Clinical data of the training set, consisting of 569 patients treated from 2000 to 2010 at Hannover Medical School, were analyzed. A prognostic model defining 3 prognostic risk groups was derived from Cox regression analyses. The score was applied and validated in an independent cohort of 557 patients from four different German centers...
July 11, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28693792/cholangiocarcinoma
#13
REVIEW
Michela Squadroni, Luca Tondulli, Gemma Gatta, Stefania Mosconi, Giordano Beretta, Roberto Labianca
Biliary tract cancer accounts for <1% of all cancers and affects chiefly an elderly population, with predominance in men. We distinguish cholangiocarcinoma (intrahepatic, hilar and distal) and gallbladder cancer, with different pathogenesis and prognosis. The treatment is based on surgery (whenever possible), radiotherapy in selected cases, and chemotherapy. The standard cytotoxic treatment for advanced/metastatic disease is represented by the combination of gemcitabine and cisplatin, whereas fluoropyrimidines are generally administered in second line setting...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28693246/genetic-alterations-in-japanese-extrahepatic-biliary-tract-cancer
#14
Rei Noguchi, Kiyoshi Yamaguchi, Tsuneo Ikenoue, Yumi Terakado, Yasunori Ohta, Naohide Yamashita, Osamu Kainuma, Sana Yokoi, Yoshiaki Maru, Hiroki Nagase, Yoichi Furukawa
Biliary tract cancer (BTC) is one of the most devastating types of malignant neoplasms worldwide. However, the mechanisms underlying the development and progression of BTC remain unresolved. BTC includes extrahepatic bile duct carcinoma (EBDC), gallbladder carcinoma (GBC) and ampulla of Vater carcinoma (AVC), named according to the location of the tumor. Although genetic alterations of intrahepatic cholangiocarcinoma have been investigated, those of EBDC, GBC and AVC have not yet been fully understood. The present study analyzed somatic mutations of 50 cancer-associated genes in 27 Japanese BTC cells, including: 11 EBDC, 14 GBC and 2 AVC...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691687/pancreaticobiliary-maljunction-and-congenital-biliary-dilatation
#15
REVIEW
Terumi Kamisawa, Kenitiro Kaneko, Takao Itoi, Hisami Ando
Pancreaticobiliary maljunction is a congenital malformation in which the pancreatic and bile ducts join outside the duodenal wall, usually forming a long common channel. Because the action of the sphincter of Oddi does not regulate the function of the pancreaticobiliary junction in patients with pancreaticobiliary maljunction, two-way regurgitation occurs. Reflux of pancreatic juice into the biliary tract is associated with a high incidence of biliary cancer. Biliary carcinogenesis in patients with pancreaticobiliary maljunction is thought to follow the hyperplasia, dysplasia, then carcinoma sequence due to chronic inflammation caused by pancreatobiliary reflux...
August 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28688125/novel-ex-vivo-training-model-for-free-hand-insertion-using-a-double-bending-peroral-direct-cholangioscope
#16
Sakiko Tsukamoto Naito, Takao Itoi, Kenjiro Yamamoto, Takayoshi Tsuchiya, Shujiro Tsuji, Reina Tanaka, Mitsuyoshi Honjo, Shuntaro Mukai, Yukitoshi Matsunami, Yasutsugu Asai, Yuichi Nagakawa, Nobuhito Ikeuchi, Atsushi Sofuni
BACKGROUND AND AIM: Several experts of direct peroral videocholangioscopy (D-PVCS) using a conventional ultraslim endoscope have reported its usefulness for the diagnosis and therapy of biliary tract diseases. We have additionally developed a dedicated double-bending D-PVCS (DBD-PVCS) technique for free-hand scope insertion. In this study, we developed an ex-vivo training model for the free-hand DBD-PVCS technique and compared it with the technique using a conventional ultraslim endoscope...
July 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28684194/adjuvant-chemotherapy-for-resected-biliary-tract-cancers-a-systematic-review-and-meta-analysis
#17
REVIEW
Michele Ghidini, Gianluca Tomasello, Andrea Botticelli, Sandro Barni, Giampietro Zabbialini, Silvia Seghezzi, Rodolfo Passalacqua, Chiara Braconi, Fausto Petrelli
INTRODUCTION: The use of adjuvant treatment (AT) in resected biliary tract cancers (BTC) is still controversial. No efficacy comparison has been performed between chemotherapy (CT) and chemoradiotherapy (CTRT). A systematic review of the available evidence regarding adjuvant chemotherapy (AC) in resected BTC was performed. METHODS: PubMed, EMBASE, Web of Science, SCOPUS and The Cochrane Library databases were searched for relevant articles published. Only studies including at least 50 patients affected by tumors of gallbladder, intrahepatic, perihilar, and distal bile ducts were considered...
July 3, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28682038/-hepato-renal-syndrome
#18
Luca Di Lullo, Claudio Ronco, Vincenzo Barbera, Francesca Santoboni, Antonio Bellasi
Hepatic and kidney failure are often closely linked (Hepato-Renal Sindrome - HRS). Acute kidney injury (AKI) represents a well-known complication of liver or biliary tract disease. Pathophysiology of HRS is still not completely clear. At this stage we know the biological pathways of several kidney abnormalities in end stage liver disease patients. At the same time patient's prognosis is poor with bad outcomes despite the reversible nature of the kidneys' involvement. Liver transplantation represents the ultimate treatment for HRS patients...
March 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28676603/-liver-pancreas-biliary-tract-cancer-surgical-strategy-for-bilobar-multiple-hepatic-metastasis
#19
Masaru Miyazaki
No abstract text is available yet for this article.
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28675356/current-management-of-perihilar-cholangiocarcinoma-and-future-perspectives
#20
Heather L Lewis, Amir A Rahnemai-Azar, Mary Dillhoff, Carl R Schmidt, Timothy M Pawlik
Perihilar cholangiocarcinoma is the most common type of biliary tract cancer and is associated with a high mortality, usually due to late presentation. High-resolution cross-sectional imaging modalities are necessary for diagnosis and preoperative planning. Although surgical resection with negative margins offers the only hope for cure, only a small subset of patients are amenable for surgery at the time of diagnosis. Portal vein embolization and biliary tract decompression are important in some patients prior to surgical resection...
May 2017: Chirurgia
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