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https://www.readbyqxmd.com/read/29679463/cdp-choline-protects-liver-from-ischemia-reperfusion-injury-preserving-mitochondrial-function-and-reducing-oxidative-stress
#1
Cecilia Zazueta, Mabel Buelna-Chontal, Arturo Macías-López, Nadia G Román-Anguiano, Héctor González-Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda-Frausto, Rafael Bojalil, Alejandro Silva-Palacios, Rodrigo Velázquez-Espejel, Sonia Galvan Arzate, Francisco Correa
CDP-choline (citicoline) participates as intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes. Citicoline treatment has shown beneficial effects in cerebral ischemia, but its potential to diminish reperfusion damage in liver has not been explored. In this work, we evaluated the hepatoprotective effect of citicoline and its possible association with inflammatory/oxidative stress and mitochondrial function, as they are main cellular features of reperfusion damage...
April 20, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29675964/antegrade-tissue-scraping-through-eus-guided-hepaticogastrostomy-with-video
#2
Takeshi Ogura, Atsushi Okuda, Kazuhide Higuchi
A novel endoscopic device (Fig 1a, Trefle, Piolax Medical Devices, Yokohama, Japan) for collecting sufficient amounts of biliary tract tissue samples under ERCP guidance for pathological diagnosis is now available in Japan [1]. Because of easy accessibility into the biliary tract through the bile duct stricture, this device might be clinically useful via a transluminal approach. Here, we described technical tips for collecting bile-duct tissue samples under EUS-guided antegrade access. A 78-year-old man who had undergone distal gastrectomy with Roux-en-Y gastrojejunostomy to treat a gastric ulcer was referred to our hospital with obstructive jaundice...
April 19, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29667091/clinical-impact-of-the-intra-scope-channel-stent-release-technique-in-preventing-stent-migration-during-eus-guided-hepaticogastrostomy
#3
Akira Miyano, Takeshi Ogura, Kazuhiro Yamamoto, Atsushi Okuda, Nobu Nishioka, Kazuhide Higuchi
BACKGROUNDS: Stent migration following endoscopic ultrasonography-guided hepaticogastrostomy (EUS-HGS) may sometimes be fatal because there are no adhesions between the biliary tract and stomach. To prevent stent migration and minimize the stent length in the abdominal cavity, we recently performed EUS-HGS using the technique of releasing the stent within the scope channel. AIMS: To examine the technical feasibility of the intra-scope channel stent release technique...
April 17, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29665667/-a-preliminary-study-on-the-application-of-two-point-traction-with-guidewire-method-in-percutaneous-transhepatic-sinus-tract-dilation
#4
J X Yang, S D Wu, J Kong, J Y Han
Objective: To explore the feasibility and effectiveness of the two-point traction with guidewire method to improve the safety of percutaneous transhepatic sinus tract dilation. Methods: The clinical data of 18 patients underwent the two-point traction guided by percutaneous transhepatic sinus dilation between January 2013 and July 2017 in Shengjing Hospital of China Medical University were analyzed retrospectively. The operation time, volume of intraoperative blood loss and postoperative complications were recorded...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29664654/annual-trends-of-gastrointestinal-cancers-mortality-in-iran-during-1990-2015-nasbod-study
#5
Hamideh Salimzadeh, Farnaz Delavari, Catherine Sauvaget, Negar Rezaee, Alireza Delavari, Farzad Kompani, Nazila Rezaei, Ali Sheidaei, Mitra Modirian, Rosa Haghshenas, Maryam Chegini, Kimiya Gohari, Hossein Zokaiee, Farshad Farzadfar, Reza Malekzadeh
BACKGROUND: Gastrointestinal (GI) neoplasms are among the most common cancers in Iran. This study aimed to measure annual trends in mortality rates from GI cancers in Iran between 1990 and 2015. METHODS: This study was part of an ongoing study termed the 'National and Subnational Burden of Diseases' study in Iran. Data used in this study was obtained from the Iranian Death Registration System (1995 to 2010) and from 2 major cemeteries in Tehran (1995 to 2010) and Isfahan (2007 to 2010)...
February 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29662598/-clinical-epidemiological-and-therapeutic-features-of-biliary-tract-cancers-about-20-cases
#6
Ibrahima Ka, Magatte Faye, Papa Saloum Diop, Amadou Bocar Niang Aliou Coly Faye, Jean Marc Ndoye, Babacar Fall
Biliary tract cancers mainly occur in two sites: gallbladder cancer which are adenocarcinomas and intra- and extrahepatic cholangiocarcinomas. We conducted a retrospective study of 20 cases with biliary tract cancer in the Department of Surgery at the General Hospital in Grand-Yoff between January 2006 and October 2014. 40% of patients had gallbladder cancer, 60% of patients had common bile duct cancer. Sex ratio was 1. The average age of patients was 58.1 years. The average time to diagnosis was 3.77 months...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29662231/processed-meat-and-risk-of-selected-digestive-tract-and-laryngeal-cancers
#7
Valentina Rosato, Daisuke Kawakita, Eva Negri, Diego Serraino, Werner Garavello, Maurizio Montella, Adriano Decarli, Carlo La Vecchia, Monica Ferraroni
BACKGROUND/OBJECTIVES: To assess the association between processed meat and the risk of selected digestive tract and laryngeal cancers. SUBJECTS/METHODS: We conducted a series of case-control studies between 1985 and 2007 in Italy. The studies included a total of 1475 cases of cancer of the oral cavity and pharynx, 1077 of the larynx, 716 of the esophagus, 999 of the stomach, 684 of the liver, 159 of the biliary tract, 688 of the pancreas, and a total of 9720 controls...
April 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29630106/to-evaluate-the-correlation-between-the-change-of-immune-system-function-before-and-after-the-treatment-of-malignant-obstructive-type-jaundice-treated-with-biliary-stent
#8
Z-K Chang, Z-P Kou, S-X Li, X-L Lou
OBJECTIVE: To evaluate the correlation between the change of immune system function before and after the treatment of malignant obstructive type jaundice (MOJ) treated with a biliary stent. PATIENTS AND METHODS: 148 patients who were admitted to the Department of Digestive System for malignant obstructive jaundice were selected according to the standardized criterion. Amongst the total sample size, 78 were male patients and 70 were female patients, with an average age of (43...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29628017/snail-borne-parasitic-diseases-an-update-on-global-epidemiological-distribution-transmission-interruption-and-control-methods
#9
REVIEW
Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
BACKGROUND: Snail-borne parasitic diseases, such as angiostrongyliasis, clonorchiasis, fascioliasis, fasciolopsiasis, opisthorchiasis, paragonimiasis and schistosomiasis, pose risks to human health and cause major socioeconomic problems in many tropical and sub-tropical countries. In this review we summarize the core roles of snails in the life cycles of the parasites they host, their clinical manifestations and disease distributions, as well as snail control methods. MAIN BODY: Snails have four roles in the life cycles of the parasites they host: as an intermediate host infected by the first-stage larvae, as the only intermediate host infected by miracidia, as the first intermediate host that ingests the parasite eggs are ingested, and as the first intermediate host penetrated by miracidia with or without the second intermediate host being an aquatic animal...
April 9, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29628007/the-new-national-registry-for-gastrointestinal-surgery-in-norway-norgast
#10
K Lassen, L S Nymo, H Kørner, K Thon, T Grindstein, H H Wasmuth, T Moger, B A Bjørnbeth, S Norderval, M T Eriksen, A Viste
BACKGROUND AND AIMS: There is an increasing demand for high-quality data for the outcome of health care. Diseases of the gastro-intestinal tract involve large patient groups often presenting with serious or life-threatening conditions. Complications may affect treatment outcomes and lead to increased mortality or reduced quality of life. A continuous, risk-adjusted monitoring of major complications is important to improve the quality of health care to patients undergoing gastrointestinal resections...
April 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29627364/animal-models-of-cholangiocarcinoma
#11
REVIEW
Emilien Loeuillard, Samantha R Fischbach, Gregory J Gores, Sumera Rizvi
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with a poor overall prognosis. There is a critical need to develop effective targeted therapies for the treatment of this lethal disease. In an effort to address this challenge, preclinical in vivo studies have become paramount in understanding CCA carcinogenesis, progression, and therapy. Various CCA animal models exist including carcinogen-based models in which animals develop CCA after exposure to a carcinogen, genetically engineered mouse models in which genetic changes are induced in mice leading to CCA, murine syngeneic orthotopic models, as well as xenograft tumors derived from xenotransplantation of CCA cells, organoids, and patient-derived tissue...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29624208/gemcitabine-based-chemotherapy-for-advanced-biliary-tract-carcinomas
#12
REVIEW
Omar Abdel-Rahman, Zeinab Elsayed, Hesham Elhalawani
BACKGROUND: Biliary tract cancers are a group of rare heterogeneous malignant tumours. They include intrahepatic and extrahepatic cholangiocarcinomas, gallbladder carcinomas, and ampullary carcinomas. Surgery remains the optimal modality of therapy leading to long-term survival for people diagnosed with resectable biliary tract carcinomas. Unfortunately, most people with biliary tract carcinomas are diagnosed with either unresectable locally-advanced or metastatic disease, and they are only suitable for palliative chemotherapy or supportive care...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29622700/hybrid-capture-based-tumor-sequencing-and-copy-number-analysis-to-confirm-origin-of-metachronous-metastases-in-brca1-mutant-cholangiocarcinoma-harboring-a-novel-ywhaz-braf-fusion
#13
Huat C Lim, Meagan Montesion, Thomas Botton, Eric A Collisson, Sarah E Umetsu, Spencer C Behr, John D Gordan, Phil J Stephens, Robin K Kelley
Biliary tract cancers such as cholangiocarcinoma represent a heterogeneous group of cancers that can be difficult to diagnose. Recent comprehensive genomic analyses in large cholangiocarcinoma cohorts have defined important molecular subgroups within cholangiocarcinoma that may relate to anatomic location and etiology [1-4] and may predict responsiveness to targeted therapies in development [5-7]. These emerging data highlight the potential for tumor genomics to inform diagnosis and treatment options in this challenging tumor type...
April 5, 2018: Oncologist
https://www.readbyqxmd.com/read/29622390/-therapeutic-advances-in-the-management-of-biliary-tract-carcinoma
#14
Sophie-Clémentine Ribiere, Chloé Léandri, Marie-Anne Guillaumot, Catherine Brezault, Romain Coriat
Cancers of the bile ducts or cholangiocarcinomas are a rare entity whose incidence is increasing in France. Surgical resection of cholangiocarcinoma remains the only curative therapy. Adjuvant therapy with capecitabine at a fixed dose of 1250mg/m2 twice daily from day 1 to day 14 (21-day cycle) for a 6 months period is now the standard of care after curative surgery. At a metastatic stage, the reference treatment consists of the combination of a platinum salt in addition to gemcitabine. No biomarker has been identified to predict the response to chemotherapy...
April 2, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29618709/-factors-related-to-frequent-emergency-hospital-refusal-of-ambulance-transport-calls
#15
Mika Kumagai, Naomi Kitano, Erika Komatsu, Hiroyuki Doba, Masami Ueno
Purpose Among the factors that adversely affect the time needed for ambulance transport, one factor for which intervention is possible is the time it takes to choose a medical receiving facility. This research clarified the characteristics of the time, location, and severity of medical emergencies in which the choice of hospital was difficult.Methods The research covered a 1-year period from January 1 through December 31, 2014, investigating all incidents of ambulance transport for patients in Wakayama Prefecture, except for those involving pediatric patients, amounting to a total of 41,574 incidents...
2018: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/29613980/use-of-intravitreal-bevacizumab-for-the-treatment-of-secondary-glaucoma-due-to-metastatic-iris-tumor
#16
Rukiye Aydin, Tongalp H Tezel
PURPOSE: To report the efficacy of intravitreal bevacizumab to resolve secondary angle closure glaucoma caused by biliary tract carcinoma metastasis to iris. ABSTRACT: A 52-year-old Caucasian woman who was under systemic chemotherapy for biliary tract carcinoma presented with metastatic tumor in the left iris. At presentation, her visual acuity was at 20/50 level. Tumor was occupying nasal half of the iris and had already occupied 5.5 clock hours of the angle resulting intraocular pressure elevation to 34▒mm Hg...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29608578/body-mass-index-and-weight-change-during-initial-period-of-chemotherapy-affect-survival-outcome-in-advanced-biliary-tract-cancer-patients
#17
Jinwoo Kang, Sang Hyub Lee, Jun Hyuk Son, Jae Woo Lee, Young Hoon Choi, Jin Ho Choi, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim
BACKGROUND: The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy. METHODS: Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29605722/efficacy-of-eus-and-ercp-guided-biliary-drainage-for-malignant-biliary-obstruction-prospective-randomized-controlled-study
#18
Joo Kyung Park, Young Sik Woo, Donghyo Noh, Ju-Il Yang, So Young Bae, Hwan Sic Yun, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuck Lee
BACKGROUND AND AIMS: ERCP-guided biliary drainage (ERCP-BD is a criterion standard treatment for malignant biliary obstruction when curative surgery is not an option. Alternative methods such as PTBD would significantly lower the quality of life. EUS-guided biliary drainage (EUS-BD) has been developed and performed by experienced endoscopists. Therefore, the aims of this study were to evaluate the efficacy and safety of EUS-BD compared with ERCP in malignant biliary obstruction. METHODS: The prospective randomized controlled study was conducted and 30 patients were enrolled; 15 for each EUS-BD and ERCP-BD arm...
March 29, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29605233/-usefulness-and-reliability-of-abdominal-clinical-ultrasound-in-family-medicine-1-liver-biliary-tract-and-pancreas
#19
Ignacio Manuel Sánchez Barrancos, Tomás Vegas Jiménez, Rafael Alonso Roca, Daniel Domínguez Tristancho, Francisco José Guerrero García, María Del Carmen Rico López, Vicente Fernández Rodríguez
Ultrasound is a safe and reliable way to increase diagnosis capabilities, as well as an improving and speed up method for taking decisions for healthcare professionals of every medical specialty. Family doctor, who must be ready to address all kind of health problems for his patients, is the key person to incorporate this tool to his daily activity, acquiring the best managing skill, unknown nowadays, being quite large the clinical situations in the day by day practice, in which he can obtain benefit in a reliable and effective way...
March 28, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29595398/outcome-of-elective-cholecystectomy-for-the-treatment-of-gallbladder-disease-in-dogs
#20
Gabina Youn, Michelle J Waschak, Kevin A R Kunkel, Patrick D Gerard
OBJECTIVE To determine mortality rates for dogs undergoing cholecystectomy and variables associated with failure to survive to hospital discharge. DESIGN Retrospective cohort study. ANIMALS 70 dogs that underwent cholecystectomy for biliary tract disease at a companion animal referral hospital from 2009 through 2015. PROCEDURES Medical records of dogs were reviewed and data collected; dogs with biliary diversion surgery were excluded. Included dogs were grouped by whether cholecystectomy had been elective (ie, dogs with no or mild clinical signs, with no indication of biliary obstruction, or that initially underwent surgery for a different procedure) or nonelective (ie, dogs with icterus and questionable patency of the biliary system)...
April 15, 2018: Journal of the American Veterinary Medical Association
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