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REVIEW
Yanjun Sun, Junfeng Gong, Zhuang Li, Lin Han, Dengqun Sun
Gallbladder cancer is a common type of biliary tract tumor. Optimal management for early stage cases typically involves radical excision as the primary treatment modality. Various surgical techniques, including laparoscopic, robotic, and navigational surgery, have demonstrated favorable clinical outcomes in radical gallbladder excision. Unfortunately, most patients are ineligible for surgical intervention because of the advanced stage of the disease upon diagnosis. Consequently, non-surgical interventions, such as chemotherapy, radiotherapy, immunotherapy, and targeted therapy, have become the mainstay of treatment for patients in advanced stages...
April 18, 2024: Postgraduate Medicine
#2
JOURNAL ARTICLE
Harufumi Maki, Yujiro Nishioka, Antony Haddad, Mateo Lendoire, Hop S Tran Cao, Yun S Chun, Ching-Wei D Tzeng, Jean-Nicolas Vauthey, Timothy E Newhook
BACKGROUND: For liver volumetry, manual tracing on computed tomography (CT) images is time-consuming and operator dependent. To overcome these disadvantages, several three-dimensional simulation software programs have been developed; however, their efficacy has not fully been evaluated. METHODS: Three physicians performed liver volumetry on preoperative CT images on 30 patients who underwent formal right hepatectomy, using manual tracing volumetry and two simulation software programs, SYNAPSE and syngo...
March 21, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
#3
Magdalena Stepien, Talita Duarte-Salles, Veronika Fedirko, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kim Overvad, Anne Tjønneland, Louise Hansen, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Krasimira Aleksandrova, Heiner Boeing, Eleni Klinaki, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Alessio Naccarati, H Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Elisabete Weiderpass, Christine L Parr, José Ramón Quirós, Genevieve Buckland, Esther Molina-Montes, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Maria Wennberg, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Kathryn E Bradbury, Heather A Ward, Isabelle Romieu, Mazda Jenab
No abstract text is available yet for this article.
April 17, 2024: European Journal of Nutrition
#4
REVIEW
Yasuyuki Kawamoto, Chigusa Morizane, Yoshito Komatsu, Shunsuke Kondo, Makoto Ueno, Satoshi Kobayashi, Masayuki Furukawa, Lingaku Lee, Taroh Satoh, Daisuke Sakai, Masafumi Ikeda, Hiroshi Imaoka, Arisa Miura, Yutaka Hatanaka, Isao Yokota, Yoshiaki Nakamura, Takayuki Yoshino
Due to the widespread use of cancer genetic testing in gastrointestinal cancer, the BRCA1/2 genetic mutation has been identified in biliary tract cancer as well as pancreatic cancer. Niraparib is a poly(ADP-ribose) polymerase (PARP) inhibitor, and PARP inhibitors exert their cytotoxicity against cancer cells in the context of homologous recombination deficiency, such as BRCA mutations, via the mechanism of synthetic lethality. The aim of this phase II NIR-B trial is to evaluate the efficacy and safety of niraparib for patients with unresectable advanced or recurrent biliary tract cancer, pancreatic cancer or other gastrointestinal cancers with germline or somatic BRCA1/2 mutations revealed by genetic testing...
April 17, 2024: Future Oncology
#5
JOURNAL ARTICLE
Melina Boutin, Tharani Krishnan, Maria Safro, Jenny Yang, Helia Jafari, Janine M Davies, Sharlene Gill
BACKGROUND: Complete resection followed by adjuvant chemotherapy is the gold standard for patients with localized cholangiocarcinoma (CC) or gallbladder cancer (GBC). However, this is not always feasible, and recurrence rates remain high. OBJECTIVES: To understand the real-world proportions and reason for treatment failure in resected biliary tract cancers. DESIGN AND METHODS: We performed a retrospective population-based review of patients with GBC or CC [intrahepatic (IHCC) or extrahepatic (EHCC)] resected between 2005 and 2019 using the BC Cancer provincial database...
2024: Therapeutic Advances in Medical Oncology
#6
JOURNAL ARTICLE
Jiancang Ma, Yingying Feng, Jinkai Xu, Zongyu Li, Jingyue Lai, Hao Guan
BACKGROUND: The incidence of gastric cancer ranks the first among digestive tract tumors in China. However, there are no specific symptoms in the early stage of the tumor and the diagnosis process is complex, so more effective detection methods are very needed. In this study, a novel long noncoding RNA (lncRNA) was introduced as a diagnostic biomarker for gastric cancer, which brought new thinking to the exploration of its pathological mechanism and clinical prediction. METHODS: The level of lncRNA EPB41L4A-AS1 (EPB41L4A-AS1) in gastric cancer serum and cells was verified via real-time quantitative polymerase chain reaction (RT-qPCR)...
April 16, 2024: BMC Gastroenterology
#7
REVIEW
Danmei Zhang, Klara Dorman, C Benedikt Westphalen, Michael Haas, Steffen Ormanns, Jens Neumann, Max Seidensticker, Jens Ricke, Enrico N De Toni, Frederick Klauschen, Hana Algül, Timo Reisländer, Stefan Boeck, Volker Heinemann
For decades, treatment of advanced biliary tract cancer (BTC) was confined to the use of chemotherapy. In recent years however, the number of therapeutic options available for patients with unresectable BTC have drastically increased, with immunotherapy and targeted treatment gradually joining the ranks of guideline-recommended treatment regimens. The aim of the present review is to summarise the current knowledge on unresectable BTC focusing on epidemiology, anatomical distribution and current strategies for systemic treatment...
April 12, 2024: European Journal of Cancer
#8
JOURNAL ARTICLE
Yiyuan Zheng, Lina Zhao, Zhekun Xiong, Chaoyuan Huang, Qiuhong Yong, Dan Fang, Yugang Fu, Simin Gu, Chong Chen, Jiacheng Li, Yingying Zhu, Jing Liu, Fengbin Liu, Yong Li
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) has become an increasingly important health challenge, with a substantial rise linked to changing lifestyles and global obesity. Ursolic acid, a natural pentacyclic triterpenoid, has been explored for its potential therapeutic effects. Given its multifunctional bioactive properties, this research further revealed the pharmacological mechanisms of ursolic acid on NAFLD. METHODS: Drug target chips and bioinformatics analysis were combined in this study to explore the potential therapeutic effects of ursolic acid on NAFLD...
April 16, 2024: Clinical and Molecular Hepatology
#9
JOURNAL ARTICLE
Harry Crane, Guy D Eslick, Cameron Gofton, Anjiya Shaikh, George Cholankeril, Mark Cheah, Jian-Hong Zhong, Gianluca Svegliati-Baroni, Alessandro Vitale, Beom Kyung Kim, Sang Hoon Ahn, Mi Na Kim, Simone Strasser, Jacob George
BACKGROUND & AIMS: The global proportion of hepatocellular carcinoma (HCC) attributable to metabolic dysfunction-associated fatty liver disease (MAFLD) is unclear. The MAFLD diagnostic criteria allows objective diagnosis in the presence of steatosis plus defined markers of metabolic dysfunction, irrespective of concurrent liver disease. We aimed to determine the total global prevalence of MAFLD in HCC cohorts (total-MAFLD), including the proportion with MAFLD as their sole liver disease (single-MAFLD), and the proportion of those with concurrent liver disease where MAFLD was a contributary factor (mixed-MAFLD)...
April 16, 2024: Clinical and Molecular Hepatology
#10
JOURNAL ARTICLE
Yi-Fan Hu, Shun-Xin Li, Hong-Li Liu, Zhi-Xiang Du, Shuang-Shuang Wang, Miao-Yang Chen, Li Wang, Qing-Fang Xiong, Yan-Dan Zhong, Du-Xian Liu, Yong-Feng Yang
BACKGROUND/AIMS: : The histological characteristics and natural history of precirrhotic primary biliary cholangitis (PBC) with portal hypertension (PH) are unclear. Our aim was to clarify the prevalence, risk factors, and histological characteristics of precirrhotic PBC patients with PH. METHODS: : This retrospective study compared the clinical features, histological characteristics, and response to ursodeoxycholic acid (UDCA) between the PH and non-PH groups of precirrhotic PBC patients...
April 16, 2024: Gut and Liver
#11
JOURNAL ARTICLE
Yuying Luo, Christie Lee Luo, Rachel Meislin, Eunyoung Yang, Xiaotao Zhang
BACKGROUND: There is a lack of data on the epidemiology of IBS in pregnant and postpartum patients in the United States. METHODS: A retrospective claims analysis was conducted in a cohort of 1,618,379 patients with ≥1 delivery hospitalization between 2013-2019 utilizing ICD-9 and ICD-10 codes after merging inpatient and outpatient claims. Obstetric, psychological, and other medical comorbidities were also examined. KEY RESULTS: The prevalence of IBS in our cohort was 1...
April 15, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#12
JOURNAL ARTICLE
Ayman Menesy, Mohamed Hammad, Salah Aref, Fatma Adel Mourad Abozeid
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract (GIT).It results in progressive intestinal epithelium structural and functional damage that necessitates lifetime medication.Thereis imbalance in the production of T helper 1 (Th1), Th2 and Th17 cytokines. This plays a crucial role in the chronic inflammatory process and the defective immune response to pathogenic agents; thus promoting the recurrence of the disease...
April 15, 2024: BMC Gastroenterology
#13
JOURNAL ARTICLE
Jonatan D Lindh, Jekaterina Patrova, Buster Mannheimer, Henrik Falhammar
IMPORTANCE: It is unclear whether nonfunctional adrenal tumors (NFATs) are associated with fractures. OBJECTIVE: To analyze fracture frequencies in individuals with NFATs. DESIGN, SETTING, AND PARTICIPANTS: A national retrospective cohort study was conducted in patients with NFATs diagnosed in Sweden between January 1, 2005, and December 31, 2019, and control participants without adrenal tumors followed up until death or the end of 2019. Individuals with a diagnosis of adrenal hormonal excess or previous malignant tumors were excluded...
April 1, 2024: JAMA Network Open
#14
REVIEW
Xin Yang, Lu Lu, Wen-Wei Zhu, Yi-Feng Tao, Cong-Huan Shen, Jin-Hong Chen, Zheng-Xin Wang, Lun-Xiu Qin
Hepatectomy is still the major curative treatment for patients with liver malignancies. However, it is still a big challenge to remove the tumors in the central posterior area, especially if their location involves the retrohepatic inferior vena cava and hepatic veins. Ex vivo liver resection and auto-transplantation (ELRA), a hybrid technique of the traditional liver resection and transplantation, has brought new hope to these patients and therefore becomes a valid alternative to liver transplantation. Due to its technical difficulty, ELRA is still concentrated in a few hepatobiliary centers that have experienced surgeons in both liver resection and liver transplantation...
April 2024: Hepatobiliary & Pancreatic Diseases International: HBPD INT
#15
EDITORIAL
Dushyant Singh Dahiya, Antonio Facciorusso, Saurabh Chandan, Amir Humza Sohail, Manesh Kumar Gangwani, Gianluca Franchellucci, Benedetto Mangiavillano
No abstract text is available yet for this article.
April 3, 2024: Hepatobiliary Surgery and Nutrition
#16
JOURNAL ARTICLE
Christian T J Magyar, Lea Bühlmann, Chiara Becchetti, Lara Beekman, Daniel Candinas, Guido Beldi, Corina Kim-Fuchs, Annalisa Berzigotti, Vanessa Banz
BACKGROUND: Physical deconditioning affects patients suffering from end-stage liver disease (ESLD). Liver transplantation (LT) is the only curative option for ESLD. Growing evidence suggests that pre-habilitation is beneficial in reducing post-surgical morbidity and mortality. We investigated physical activity (PA) in patients awaiting LT in a country with long waiting times. METHODS: Prospective, single center, longitudinal study in Bern, Switzerland between June 2019 and February 2020 (halted due to SARS-CoV-2 pandemic), with follow-up data up to six months post-transplant...
April 3, 2024: Hepatobiliary Surgery and Nutrition
#17
EDITORIAL
Dimitrios Ntourakis, Evangelia Triantafyllou, Christiana Roidi, Panagiotis Lainas
No abstract text is available yet for this article.
April 3, 2024: Hepatobiliary Surgery and Nutrition
#18
EDITORIAL
Fadi H Mourad, Najwa F Mourad, Jana G Hashash
No abstract text is available yet for this article.
April 3, 2024: Hepatobiliary Surgery and Nutrition
#19
EDITORIAL
Paola A Vargas, Nicolas Goldaracena
No abstract text is available yet for this article.
April 3, 2024: Hepatobiliary Surgery and Nutrition
#20
JOURNAL ARTICLE
Sara Ingallinella, Francesco Ardito, Francesca Ratti, Rebecca Marino, Marco Catena, Agostino Maria De Rose, Francesco Razionale, Filippo Rumi, Americo Cicchetti, Felice Giuliante, Luca Aldrighetti
BACKGROUND: Economic impact of robotic liver surgery (RLS) is still a debated issue due to the heterogeneity of liver resections considered and the lack of a rigorous methodology. Therefore, the aim of this study is to perform a time-driven activity-based costing (TD-ABC) comparing the costs of RLS, laparoscopic liver surgery (LLS) and open liver surgery (OLS) in the context of complex liver resections and to compare short term perioperative outcomes. METHODS: The institutional databases of two Italian high volume hepatobiliary centres were retrospectively reviewed from February 2021 to April 2022...
April 3, 2024: Hepatobiliary Surgery and Nutrition
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