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https://www.readbyqxmd.com/read/29457045/efficacy-of-endoscopic-retrograde-cholangiopancreatography-in-the-treatment-of-biliary-complications-following-liver-transplant-10-years-of-a-single-centre-experience
#1
Ana Rita Alves, Dário Gomes, Emanuel Furtado, Luís Tomé
Background and Aims: Biliary tract complications following liver transplant remain an important source of morbidity and mortality. Endoscopic retrograde cholangiopancreatography (ERCP) has become a common therapeutic option before other invasive procedures. The aim of this study was to evaluate ERCP efficacy in managing this type of complications. Methods: Retrospective study of all patients who underwent therapeutic ERCP due to post-liver transplant biliary complications between September 2005 and September 2015, at a deceased donor liver transplantation centre...
January 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29454743/corrigendum-to-precision-medicine-for-patients-with-advanced-biliary-tract-cancers-an-effective-strategy-within-the-prospective-moscato-01-trial-eur-j-cancer-87-2017-122-130
#2
Loic Verlingue, David Malka, Adrien Allorant, Christophe Massard, Charles Ferté, Ludovic Lacroix, Etienne Rouleau, Nathalie Auger, Maud Ngo, Claudio Nicotra, Thierry De Baere, Lambros Tselikas, Bakar Ba, Stefan Michiels, Jean-Yves Scoazec, Valérie Boige, Michel Ducreux, Jean-Charles Soria, Antoine Hollebecque
No abstract text is available yet for this article.
February 14, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29452147/combination-of-kras-activation-and-pten-deletion-contributes-to-murine-hepatopancreatic-ductal-malignancy
#3
Yun-Kai Lin, Zheng Fang, Tian-Yi Jiang, Zheng-Hua Wan, Yu-Fei Pan, Yun-Han Ma, Yuan-Yuan Shi, Ye-Xiong Tan, Li-Wei Dong, Yong-Jie Zhang, Hong-Yang Wang
Kras mutations are among the most common genetic abnormalities in human neoplasms, including cholangiocarcinomas, pancreatic cancer and colon cancer. PTEN has previously been associated with cholangiocarcinoma development in murine models. Here, we have established novel mouse models of neoplasms by liver-specific and biliary-pancreatic Kras activation and PTEN deletion. By liver-specific disruption of PTEN and activation of Kras in mice caused rapid development of intrahepatic biliary epithelial proliferative lesions (Intrahepatic cholangiocarcinoma, ICC), which progress through dysplasia to invasive carcinoma...
February 13, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29451425/biliary-tract-infecting-myxosporeans-from-estuarine-and-reef-stonefish-scorpaeniformes-synanceiidae-off-eastern-australia-with-descriptions-of-sphaeromyxa-horrida-n-sp-and-myxidium-lapipiscis-n-sp-myxosporea-bivalvulida
#4
Terrence Miller, Samantha Barnett, Jamie Seymour, Timothy Jenkins, Marissa McNamara, Robert Douglas Adlard
Two new species of myxosporeans are described from the gall bladders of Estuarine Stonefish, Synanceia horrida, and Reef Stonefish, Synanceia verrucosa, from localities off Cairns, in tropical north Queensland (QLD) and in Moreton Bay in southern QLD, Australia. Sphaeromyxa horrida n. sp. can be distinguished from congeners in the morphologically distinct "balbianii" species group within Sphaeromyxa based on morphometric differences in length and width of mature spores, length and width of polar capsules and unique SSU rDNA sequence composition relative to other taxa...
February 16, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29450669/association-of-tert-clptm1l-and-8q24-common-genetic-variants-with-gallbladder-cancer-susceptibility-and-prognosis-in-north-indian-population
#5
Saurabh Yadav, Abhijit Chandra, Ashok Kumar, Balraj Mittal
Gallbladder carcinoma (GBC) is one of the common malignancy of the biliary tract. Several genome wide and candidate gene studies have reported associations between multiple cancer types and single-nucleotide polymorphisms on 5p15.33 and 8q24.21 loci. However, predisposition potential of these genetic variants has not been assessed in GBC. We performed the present study to assess the potential of five polymorphisms on 5p15.33 and one on 8q24.21 locus in GBC risk and treatment response in patients undergoing chemoradiotherapy...
February 15, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29449577/neutralization-of-il-15-abrogates-experimental-immune-mediated-cholangitis-in-diet-induced-obese-mice
#6
José L Reyes, Danielle T Vannan, Tina Vo, Aliya Gulamhusein, Paul L Beck, Raylene A Reimer, Bertus Eksteen
Obesity is a global epidemic affecting chronic inflammatory diseases. Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can occur as an extraintestinal manifestation of inflammatory bowel disease (IBD). Previously we reported that patients with PSC who are obese have a higher risk of advanced liver disease. Currently it is unknown how obesity accelerates or worsens PSC. We evaluated the progression of PSC in an antigen-driven cholangitis mouse model of diet-induced obesity. Obesity was induced in our murine model of immune-mediated cholangitis (OVAbil)...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448202/the-correlation-between-serum-chemokines-and-clinical-outcome-in-patients-with-advanced-biliary-tract-cancer
#7
Su Jin Lee, Jung Eun Kim, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Won Ki Kang, Young Suk Park, Ho Yeong Lim
BACKGROUND: Biliary tract cancers (BTCs) are known to have a dismal prognosis. A number of chemokines play important roles in the progress of BTCs. However, the serum levels of chemokines in BTCs have not yet been explored. METHODS: The sera of healthy donors (n = 8) and patients with BTCs who were enrolled in second line sunitinib trials (n = 27) were collected. The concentrations of three kinds of chemokines (CXCL5, CXCL8 and CXCL12) were measured using ELISA assay...
February 12, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29442062/gallstone-ileus-in-a-ninety-two-years-old-colecistectomized-patient-after-endoscopic-biliary-sphincterotomy-a-case-report
#8
S Fedele, P Lobascio, G Carbotta, G Balducci, R Laforgia, M G Sederino, M Minafra, A Delvecchio, N Palasciano
INTRODUCTION: Gallstone ileus is an uncommon condition of mechanical bowel obstruction caused by the passage of a gallstone into the bowel. It occurs more frequently in female patients older than 65 years and often for a biliary-enteric fistula. The pathognomonic features of gallstone ileus - the Rigler's triad - are pneumobilia, ectopic gallstone and bowel obstruction. Less commonly, a gallstone may enter the intestinal lumen through the common bile duct, after endoscopic retrograde cholangiopancreatography, and very rarely in colecistectomized patient...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29438681/the-diagnostic-value-of-five-serum-tumor-markers-for-patients-with-cholangiocarcinoma
#9
Yuanfu Qiu, Jian He, Xinliang Chen, Pinbo Huang, Kaishun Hu, Haiyan Yan
OBJECTIVE: To assess the clinical significance and diagnostic value of the single and combined detection of five tumor markers in patients with cholangiocarcinoma. METHODS: In total, 296 patients with biliary tract disease who were diagnosed and received treatment at Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University during April 2011 to Dec 2017 were chosen for this study. Patients were divided into a cholangiocarcinoma group and a benign biliary tract disease group...
February 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29437771/hepatotoxicity-associated-with-vismodegib
#10
Prabhjot S Bedi, Manoj P Rai, Nishant Tageja, Heather Laird-Fick
An 82-year-old Caucasian woman with a history of basal cell carcinoma on vismodegib presented with nausea, vomiting and intermittent abdominal pain. Laboratory results were remarkable for the elevation of liver enzymes. Endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiogram (PTC) did not show evidence of intrahepatic or extrahepatic obstruction of the biliary tract. During PTC external biliary catheter was placed; however, bilirubin continued to rise. Further, laboratory work-up and imaging studies ruled out other possible aetiologies for hepatotoxicity such as infections, autoimmune hepatitis and other drugs known to be hepatotoxic thus leaving vismodegib the most likely cause of hepatotoxicity...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29429533/the-effect-of-chemotherapy-on-nutritional-status-and-weakness-in-geriatric-gastrointestinal-system-cancer-patients
#11
Derya Hopanci Bicakli, Ahmet Ozveren, Ruchan Uslu, Reci Meseri Dalak, Ruksan Cehreli, Mehmet Uyar, Bulent Karabulut, Fehmi Akcicek
OBJECTIVES: Malnutrition is common in patients with geriatric gastrointestinal system (GIS) cancer. This study aimed to evaluate patients with geriatric GIS cancer in terms of nutritional status and weakness and determine the changes caused by chemotherapy (CT). METHODS: Patients with geriatric GIS cancer who received CT were included in the study. Their nutritional status was assessed with the Mini Nutritional Assessment, and weakness was assessed with the handgrip strength/body mass index ratio...
March 2018: Nutrition
https://www.readbyqxmd.com/read/29429510/characterization-and-spatial-relationships-of-the-hepatic-vascular-biliary-tracts-and-their-associated-pancreocytes-and-macrophages-in-the-model-fish-guppy-poecilia-reticulata-a-study-of-serial-sections-by-light-microscopy
#12
Sisandra Sousa, Maria J Rocha, Eduardo Rocha
The guppy is a tropical fish that has been used as an experimental model organism in science. It is a species well adapted to the natural environment and that can support adverse environmental conditions, and so, at occasions, its presence can be indicative of environmental disturbances. Moreover, as the liver is very important when studying fish diseases, the knowledge of normal microanatomy is essential to assess histological changes, e.g., related to environmental change or toxic pollutants. The target organ of this histological study is the liver...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29428100/clinical-analysis-of-liver-transplantation-in-autoimmune-liver-diseases
#13
Cheng-Peng Zhong, Zhi-Feng Xi, Qiang Xia
BACKGROUND: Autoimmune liver diseases (ALDs) consist of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), IgG4-associated cholangitis and overlap syndromes. Patients with these diseases may gradually progress to end-stage liver diseases and need liver transplantation. The present study aimed to explore the prognosis of patients with ALDs after liver transplantation. METHODS: The clinical data of 80 patients with ALD (24 cases of AIH, 35 of PBC, 15 of PSC and 6 of AIH-PBC overlap syndromes) who underwent liver transplantation in Renji Hospital, Shanghai Jiao Tong University School of Medicine from June 2004 to September 2016 were collected retrospectively...
February 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29417387/fitz-hugh-curtis-syndrome-in-a-man-positive-for-chlamydia-trachomatis
#14
Kazuhide Takata, Hiromi Fukuda, Kaoru Umeda, Ryo Yamauchi, Sho Fukuda, Hideo Kunimoto, Takashi Tanaka, Keiji Yokoyama, Daisuke Morihara, Yasuaki Takeyama, Makoto Irie, Satoshi Shakado, Shotaro Sakisaka
Fitz-Hugh-Curtis syndrome (FHCS) is characterized by perihepatic and pelvic inflammation and occurs mostly in women of childbearing age. Here, we report a case of FHCS caused by Chlamydia trachomatis in a 50-year-old man. The patient presented to our hospital with right upper quadrant abdominal pain, and enhanced computed tomography revealed perihepatic and pelvic free fluid and early-phase hepatic capsular enhancement. A urine specimen was positive for Chlamydia trachomatis. The patient was diagnosed with FHCS due to Chlamydia trachomatis infection...
February 7, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29416916/genotyping-and-mrna-profiling-reveal-actionable-molecular-targets-in-biliary-tract-cancers
#15
Kyriaki Papadopoulou, Samuel Murray, Kyriaki Manousou, Ioannis Tikas, Christos Dervenis, Joseph Sgouros, Dimitra Rontogianni, Sotirios Lakis, Mattheos Bobos, Christos Poulios, Stavroula Pervana, Georgios Lazaridis, George Fountzilas, Vassiliki Kotoula
Biliary tract cancer (BTC) represents a heterogeneous disease with dismal outcome. Herein, we examined genotype and angiogenesis features in BTC. We applied genotyping (Sanger, qPCR, 101-gene panel NGS), mRNA relative quantification methods, and β-catenin immunohistochemistry in 84 FFPE BTC (55 gallbladder [GBC], 14 intrahepatic [ICC], 15 extrahepatic [ECC] carcinomas). We identified 541 mutations in 68 (81%) tumors. Top mutated genes were CTNNB1 (36%); PTEN (33%); TP53 (31%); PIK3R1 (29%); PIK3CA (13%); BRCA2 and KRAS (12%); BRCA1 (11%)...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29416321/perioperative-outcome-of-elderly-versus-younger-patients-undergoing-major-hepatic-or-pancreatic-surgery
#16
Qiang Lu, Jian-Wen Lu, Zheng Wu, Xue-Min Liu, Jian-Hui Li, Jian Dong, Guo-Zhi Yin, Yi Lv, Xu-Feng Zhang
Objective: The aim of this study was to determine the safety of elderly cancer patients (≥70 years) undergoing hepatic resection (HR) or pancreaticoduodenectomy (PD) in comparison with younger adults (<70 years). Methods: A total of 1,012 consecutive patients undergoing HR or PD were included. The incidence and severity of morbidity were documented within 30 days postoperatively and compared between elderly and younger groups. Risk factors associated with postoperative morbidity were investigated by multivariate logistic regression analysis...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29413947/styk1-promotes-cancer-cell-proliferation-and-malignant-transformation-by-activating-pi3k-akt-pathway-in-gallbladder-carcinoma
#17
Yun-Ping Hu, Zeng-Bin Wu, Lin Jiang, Yun-Peng Jin, Huai-Feng Li, Yi-Jian Zhang, Qiang Ma, Yuan-Yuan Ye, Zheng Wang, Yong-Chen Liu, Hong-Zhuan Chen, Ying-Bin Liu
Gallbladder carcinoma (GBC) is the most common malignancy of the biliary tract with extremely poor prognosis. The malignant transformation of GBC is associated with cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). However, the molecular mechanisms underlying GBC progression are poorly understood. We found that serine threonine tyrosine kinase 1 (STYK1) was elevated in GBC and was negatively correlated with clinical outcomes and prognosis. Overexpression of STYK1 in GBC cell lines gave rise to increased cell proliferation, colony formation, migration and invasion, thus committing cells to undergoing EMT...
January 31, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29413685/picca-study-panitumumab-in-combination-with-cisplatin-gemcitabine-chemotherapy-in-kras-wild-type-patients-with-biliary-cancer-a-randomised-biomarker-driven-clinical-phase-ii-aio-study
#18
Arndt Vogel, Stefan Kasper, Michael Bitzer, Andreas Block, Marianne Sinn, Henning Schulze-Bergkamen, Markus Moehler, Nicole Pfarr, Volker Endris, Benjamin Goeppert, Kirsten Merx, Elisabeth Schnoy, Jens T Siveke, Patrick Michl, Dirk Waldschmidt, Jan Kuhlmann, Michael Geissler, Christoph Kahl, Ralf Evenkamp, Torben Schmidt, Alexander Kuhlmann, Wilko Weichert, Stefan Kubicka
BACKGROUND: Combination chemotherapy has shown benefit in the treatment of biliary cancer and further improvements might be achieved by the addition of a biological agent. We report here the effect of chemotherapy with the monoclonal EGFR antibody panitumumab as therapy for KRAS wild-type biliary cancer. PATIENTS AND METHODS: Patients with advanced biliary tract cancer were randomised (2:1) to receive cisplatin 25 mg/m2 and gemcitabine 1000 mg/m2 on day 1 and day 8/q3w with (arm A) or without panitumumab (arm B; 9 mg/kg BW, i...
January 31, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29402439/drug-development-and-clinical-trial-design-in-pancreatico-biliary-malignancies
#19
REVIEW
Jennifer Harrington, Louise Carter, Bristi Basu, Natalie Cook
Pancreatico-biliary (P-B) tumors arise from the pancreas, bile duct, and ampulla of Vater. Despite their close anatomical location, they have different etiology and biology. However, they uniformly share a poor prognosis, with no major improvements observed in overall survival over decades, even in the face of progress in diagnostic imaging and surgical techniques, and advances in systemic and loco-regional radiation therapies. To date, cytotoxic treatment has been associated with modest benefits in the advanced disease setting, and survival for patients with stage IV disease has not exceeded a year...
January 8, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29398347/epc-hpsg-evidence-based-guidelines-for-the-management-of-pediatric-pancreatitis
#20
REVIEW
Andrea Párniczky, Maisam Abu-El-Haija, Sohail Husain, Mark Lowe, Grzegorz Oracz, Miklós Sahin-Tóth, Flóra K Szabó, Aliye Uc, Michael Wilschanski, Heiko Witt, László Czakó, Tassos Grammatikopoulos, Ib Christian Rasmussen, Robert Sutton, Péter Hegyi
BACKGROUND: Pediatric pancreatitis is an underdiagnosed disease with variable etiology. In the past 10-15 years the incidence of pediatric pancreatitis has increased, it is now 3.6-13.3 cases per 100,000 children. Up-to-date evidence based management guidelines are lacking for the pediatric pancreatitis. The European Pancreatic Club, in collaboration with the Hungarian Pancreatic Study Group organized a consensus guideline meeting on the diagnosis and management of pancreatitis in the pediatric population...
January 4, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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