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https://www.readbyqxmd.com/read/27908907/importance-of-diagnostic-work-up-of-guillain-barr%C3%A3-syndrome-in-pregnancy
#1
Elza Pollak-Christian, Kyong-Soon Lee
We report a full-term neonate presenting with symptomatic congenital cytomegalovirus (CMV) infection with hepatosplenomegaly, 'blueberry muffin' rash, intracranial calcifications, thrombocytopenia and respiratory distress. Maternal history was relevant for Guillain-Barré syndrome (GBS) during the first trimester of pregnancy. CMV infection is an important cause of GBS; thus, women presenting GBS during pregnancy should be screened for CMV infection. If positive, they may benefit from specialised monitoring and treatment in the antenatal period, which may decrease the risk of major neurodevelopmental sequelae of congenital CMV in the neonate...
December 1, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27900946/childhood-psoriasis
#2
Emmanuel Mahé
Psoriasis is a common chronic inflammatory skin disease. Recently, few data have been published on epidemiology, comorbidity, or therapy in children with psoriasis. Psoriasis affects up to 2% of children in Europe, even during the first months of life. The link between psoriasis and metabolic comorbidities has been highlighted, notably in relation to excessive weight and obesity. The clinical picture of psoriasis in childhood resembles adult disease, however, some clinical features are noteworthy: neonatal diaper rash is relatively specific, face involvement and guttate psoriasis are more common, plaques are often smaller, and scales are finer and softer than in adults...
November 29, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27872772/an-uncommon-feature-of-chronic-granulomatous-disease-in-a-neonate
#3
Razieh Afrough, Sayyed Shahabeddin Mohseni, Setareh Sagheb
Chronic Granulomatous Disease (CGD) represents recurrent life-threatening bacterial and fungal infections and granuloma formation with a high mortality rate. CGD's sign and symptoms usually appear in infancy and children before the age of five; therefore, its presentation in neonatal period with some uncommon features may be easily overlooked. Here we describe a case of CGD in a 24-day-old boy, presenting with a diffuse purulent vesiculopustular rash and multiple osteomyelitis.
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27869384/-atypical-mucocutaneous-manifestations-in-neonates-and-infants-with-chikungunya-fever-in-the-municipalities-of-c%C3%A3%C2%BAcuta-los-patios-and-villa-del-rosario-norte-de-santander-colombia-2014
#4
Claudia Marcela Muñoz, José Orlando Castillo, Daniela Salas, Milena Alexandra Valderrama, Claudia Teresa Rangel, Heiddy Patricia Vargas, Diana Carolina Silva
INTRODUCTION: Atypical clinical manifestations have been observed in newborns and infants suffering from fever caused by the chikungunya virus. Objective: To describe the cases of fever caused by the chikungunya virus in newborns and infants with atypical mucocutaneous lesions. Materials and methods: We reviewed the clinical records, as well as lab tests and histopathological results, of newborns and infants diagnosed with Chikungunya virus and atypical mucocutaneous lesions in three regional hospitals...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27760897/a-term-infant-of-neonatal-toxic-shock-syndrome-like-exanthematous-disease-complicated-with-hemophagocytic-syndrome
#5
Akimune Kaga, Hiroshi Watanabe, Hiroki Miyabayashi, Takaya Metoki, Setsuko Kitaoka, Satoru Kumaki
Neonatal toxic shock syndrome-like exanthematous disease (NTED) is a newly recognized neonatal infectious disease, caused by the superantigen toxic shock syndrome toxin-1 (TSST-1). TSST-1 is mainly produced by methicillin-resistant Staphylococcus aureus, and the immune responses to TSST-1 are known to cause toxic shock syndrome, a life-threatening infectious disease. The clinical symptoms of NTED are skin rash, fever, and thrombocytopenia, but severe thrombocytopenia is rare in term infants with NTED. Although the cause of NTED is the same as that of toxic shock syndrome, the clinical symptoms of NTED are milder than toxic shock syndrome...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27659743/-mevalonate-kinase-deficiency-in-2016
#6
C Galeotti, S Georgin-Lavialle, G Sarrabay, I Touitou, I Koné-Paut
Mevalonate kinase deficiency is a rare, autosomal recessive, auto-inflammatory disease. This results from mutations in the gene MVK coding for the enzyme mevalonate kinase. This enzyme is involved in cholesterol and isoprenoids synthesis. Depending partially of the residual activity of the mevalonate kinase, the clinical spectrum realizes a continuum which extends from the mild phenotype of the hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) to a lethal form of mevalonic aciduria. The HIDS is characterized by recurrent episodes of fever with an intense inflammatory syndrome, accompanied with lymphadenopathy, abdominal pain, diarrhea, arthralgia, hepatomegaly, splenomegaly and skin rash...
September 19, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27619845/congenital-and-perinatal-complications-of-chikungunya-fever-a-latin-american-experience
#7
Jaime R Torres, Luiza H Falleiros-Arlant, Lourdes Dueñas, Jorge Pleitez-Navarrete, Doris M Salgado, José Brea-Del Castillo
BACKGROUND: During the years 2014 and 2015, the Region of the Americas underwent a devastating epidemic of chikungunya virus (CHIKV) of the Asian genotype, resulting in millions of affected individuals. However, epidemiological and clinical information on this experience is scarce. Prior knowledge of congenital and neonatal illness caused by CHIKV is limited and almost exclusively based on data obtained from a single outbreak of the East/Central/South African (ECSA) genotype. The effect of chikungunya fever (CHIKF) on pregnancy outcomes and its consequences for infants born to infected mothers at the peak of the epidemic wave in Latin America are reviewed herein...
September 13, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27588032/distinctive-clinical-features-of-hpev-3-infection-in-2-neonates-with-a-sepsis-like-illness
#8
Jung Sook Yeom, Ji Sook Park, Ji-Hyun Seo, Eun Sil Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Ok Jeong Lee, Tae-Hee Han, Ju-Young Chung
We report a human parechovirus-3 (HPeV-3) infection in 2 neonates who had prolonged fever (>5 days) with palmar-plantar erythema. This distinctive rash was observed 4-5 days after fever onset, just before defervescence. Elevated aspartate aminotransferase, lactate dehydrogenase, and ferritin levels were characteristic laboratory findings in the 2 cases, suggesting tissue damage caused by hypercytokinemia. Case 1 was treated with intravenous immunoglobulin, considering the possibility of severe systemic inflammatory responses...
July 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27582066/a-neonatal-mouse-model-for-the-evaluation-of-antibodies-and-vaccines-against-coxsackievirus-a6
#9
Lisheng Yang, Qunying Mao, Shuxuan Li, Fan Gao, Huan Zhao, Yajing Liu, Junkai Wan, Xiangzhong Ye, Ningshao Xia, Tong Cheng, Zhenglun Liang
Coxsackievirus A6 (CA6) can induce atypical hand, foot, and mouth disease, which is characterized by severe rash, onychomadesis and a higher rate of infection in adults. Increasing epidemiological data indicated that outbreaks of CA6-associated hand, foot, and mouth disease have markedly increased worldwide in recent years. However, the current body of knowledge on the infection, pathogenic mechanism, and immunogenicity of CA6 is still very limited. In this study, we established the first neonatal mouse model for the evaluation of antibodies and vaccines against CA6...
October 2016: Antiviral Research
https://www.readbyqxmd.com/read/27563537/microbiology-laboratory-and-the-management-of-mother-child-varicella-zoster-virus-infection
#10
REVIEW
Massimo De Paschale, Pierangelo Clerici
Varicella-zoster virus, which is responsible for varicella (chickenpox) and herpes zoster (shingles), is ubiquitous and causes an acute infection among children, especially those aged less than six years. As 90% of adults have had varicella in childhood, it is unusual to encounter an infected pregnant woman but, if the disease does appear, it can lead to complications for both the mother and fetus or newborn. The major maternal complications include pneumonia, which can lead to death if not treated. If the virus passes to the fetus, congenital varicella syndrome, neonatal varicella (particularly serious if maternal rash appears in the days immediately before or after childbirth) or herpes zoster in the early years of life may occur depending on the time of infection...
August 12, 2016: World Journal of Virology
https://www.readbyqxmd.com/read/27531861/diffuse-periventricular-calcification-and-brain-atrophy-a-case-of-neonatal-central-nervous-system-cytomegalovirus-infection
#11
Thomas R Sanchez, Mitchell D Datlow, Anna E Nidecker
TORCH refers to the most common congenitally acquired infections: toxoplasma, rubella, cytomegalovirus, and herpes simplex virus. Neonatal cytomegalovirus infection remains a common cause of congenital infection worldwide with effects ranging from hearing impairment to significant neurological morbidity. We report a case of a term neonate with ventriculomegaly on prenatal ultrasound who presented with low birth weight, small head circumference, hepatosplenomegaly, and purpuric rash on physical exam. Central nervous system cytomegalovirus infection typically shows periventricular calcifications and associated deep white matter damage and ventriculomegaly...
October 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27500084/neonatal-encephalitis-due-to-chikungunya-vertical-transmission-first-report-in-brazil
#12
Antonio Carlos Bandeira, Gubio Soares Campos, Silvia Ines Sardi, Veronica França Diniz Rocha, Guilherme Cesar Mendes Rocha
PURPOSE: To report the first case of Chikungunya encephalitis acquired in the perinatal period during the current outbreak in Brazil. METHODS: Case report. RESULTS: A male neonate with 3500 g developed macular erythematous rash, hypoactivity and fever progressing to generalized seizures. His mother had experienced a disseminated rash and fever before delivery. EEG showed diffuse slowing and cranial NMR was suggestive of encephalitis. Rt-PCR for Chikungunya virus (CHIKV) was positive in cerebrospinal fluid (CSF), blood, urine and saliva...
2016: IDCases
https://www.readbyqxmd.com/read/27458596/staphylococcal-bullous-impetigo-in-a-neonate
#13
Shalini Dewan Duggal, Tanisha Bharara, Pragnya Paramita Jena, Avinash Kumar, Abha Sharma, Renu Gur, Sanjay Chaudhary
An otherwise healthy, full-term neonate presented at day 15 of life to the pediatric emergency with generalized papulo-pustular rash for 2 d. This was finally diagnosed as bullous impetigo caused by Staphylococcus aureus (S. aureus). The skin lesions decreased significantly after starting antibiotic therapy and drainage of blister fluid. There was no recurrence of the lesions on follow-up. This case of generalized pustular eruption due to S. aureus in a neonate is reported, as it poses a diagnostic dilemma and can have serious consequences if left untreated...
July 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27455441/prevalence-serotype-distribution-and-mortality-risk-associated-with-group-b-streptococcus-colonization-of-newborns-in-rural-bangladesh
#14
Mohammad Shahidul Islam, Samir K Saha, Maksuda Islam, Joyanta K Modak, Rashed Shah, Radwanur R Talukder, Shams El Arifeen, Abdullah H Baqui, Gary L Darmstadt, Luke C Mullany
BACKGROUND: Group B Streptococcus (GBS) is a predominant cause of early-onset neonatal sepsis (EOS) globally; however, the impact of this organism on the health of newborns in South Asia is debated, due in part to a paucity of community-based assessments. We estimated the prevalence and serotypes of GBS colonization of the umbilical cord stump, and the association of colonization with mortality in a population-based cohort of newborns in rural Sylhet District, Bangladesh. METHODS: Umbilical cord swabs were collected from 646 newborns up to three times within the first week after birth (ages <24 hours, ~3 days, ~6 days) and processed to identify GBS serotypes...
July 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27435956/muckle-wells-syndrome-a-case-report-with-an-nlrp3-t348m-mutation
#15
Elena Naz Villalba, Enrique Gomez de la Fuente, Dolores Caro Gutierrez, Fernando Pinedo Moraleda, Julio Yanguela Rodilla, Diana Mazagatos Angulo, Jose Luis López Estebaranz
Autoinflammatory syndromes are a recently described group of conditions caused by mutations in multiple genes that code for proteins of the innate immune system. Cryopyrin-associated periodic syndromes are autoinflammatory diseases comprising three clinically overlapping disorders: familial cold urticaria syndrome, Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease. MWS is characterized by a moderate phenotype with fever, rash, arthralgia, conjunctivitis, sensorineural deafness, and potentially life-threatening amyloidosis...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27335642/improving-maternal-confidence-in-neonatal-care-through-a-checklist-intervention
#16
Dina Radenkovic, Shrinal Kotecha, Shreena Patel, Anjali Lakhani, Katharina Reimann-Dubbers, Shreya Shah, Daniyal Jafree, Stefan Mitrasinovic, Melissa Whitten
Previous qualitative studies suggest a lack of maternal confidence in care of their newborn child upon discharge into the community. This observation was supported by discussion with healthcare professionals and mothers at University College London Hospital (UCLH), highlighting specific areas of concern, in particular identifying and managing common neonatal presentations. The aim of this study was to design and introduce a checklist, addressing concerns, to increase maternal confidence in care of their newborn child...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27304999/neonatal-haemophagocytic-lymphohistiocytosis-associated-with-maternal-adult-onset-still-s-disease
#17
Anna Lin, Terence Ping Yuen Ma, Frankie Wai Tsoi Cheng, Pak Cheung Ng
Neonatal haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially lethal condition. We recently encountered a preterm infant who developed severe HLH associated with maternal adult-onset Still's disease, which to our knowledge has not been previously reported. The infant presented with fever, generalised lymphadenopathy, transient erythematous skin rash, hepatosplenomegaly, ascites, pancytopenia, marked hyperferritinaemia, and hypofibrinogenaemia, which were features similar to maternal presentation during late pregnancy...
June 16, 2016: Neonatology
https://www.readbyqxmd.com/read/27291942/fetal-hypoxia-secondary-to-severe-maternal-anemia-as-a-causative-link-between-blueberry-muffin-baby-and-erythroblastosis-a-case-report
#18
Maria Pia De Carolis, Silvia Salvi, Iliana Bersani, Serafina Lacerenza, Costantino Romagnoli, Sara De Carolis
BACKGROUND: Neonatal blueberry muffin lesions are rare cutaneous eruptions, presenting as transient, non-blanching, red-violaceous papules, mostly localized in the trunk, head and neck, attributable to a marked dermal hematopoietic activity. Congenital infections of the TORCH complex (toxoplasmosis, other, rubella, cytomegalovirus and herpes) and hematological disorders have been classically associated with this neonatal dermatological manifestation. We report for the first time an unusual presentation of blueberry muffin lesions in a neonate born from a mother affected by severe anemia during pregnancy...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27149142/enterovirus-infection-in-febrile-neonates-a-hospital-based-prospective-cohort-study
#19
Xiao-Qing Lv, Ling-He Qian, Tai Wu, Tian-Ming Yuan
AIM: This study aims to investigate clinical characteristics and microbiological results and to assess the predictors for enterovirus infection in febrile neonates. METHODS: A prospective cohort study was conducted on 334 febrile patients (age: 0.33-28 days) in 2011-2012 years. Enterovirus RNA was detected by reverse transcription polymerase chain reaction on faeces or cerebrospinal fluid (CSF). Clinical characteristics were compared, and non-conditional logistic regression analysis was performed to determine independent predictors for enterovirus infection...
August 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27139027/polarisation-of-equine-pregnancy-outcome-associated-with-a-maternal-mhc-class-i-allele-preliminary-evidence
#20
J H Kydd, R Case, C Winton, S MacRae, E Sharp, S L Ricketts, N Rash, J R Newton
Identification of risk factors which are associated with severe clinical signs can assist in the management of disease outbreaks and indicate future research areas. Pregnancy loss during late gestation in the mare compromises welfare, reduces fecundity and has financial implications for horse owners. This retrospective study focussed on the identification of risk factors associated with pregnancy loss among 46 Thoroughbred mares on a single British stud farm, with some but not all losses involving equid herpesvirus-1 (EHV-1) infection...
May 30, 2016: Veterinary Microbiology
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