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https://www.readbyqxmd.com/read/29930810/efficacy-of-orlistat-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#1
Hu Wang, Li Wang, Yujia Cheng, Zhiqing Xia, Yifeng Liao, Jiang Cao
In the present meta-analysis, the efficacy and safety of orlistat in the treatment of non-alcoholic fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH) were evaluated. PubMed, Embase, the Cochrane Library, Web of Science, and Wan Fang data were searched for controlled trials of orlistat in patients with NAFLD or NASH, published before August 2017. Three randomized controlled trials and four single-arm trials were included. The involved participants with NAFLD or NASH (330 patients) were analyzed for clinical outcomes including alteration in hepatic histological variables and biomarkers of liver function...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29929928/the-association-of-sleep-duration-and-sleep-quality-with-non-alcoholic-fatty-liver-disease-in-a-taiwanese-population
#2
Yu-Tsung Chou, Hsiang-Ju Cheng, Jin-Shang Wu, Yi-Ching Yang, Chieh-Ying Chou, Chih-Jen Chang, Feng-Hwa Lu
OBJECTIVE: The association of sleep duration/quality with nonalcoholic fatty liver disease (NAFLD) is inconclusive. Several important covariates were not adjusted concomitantly in some studies, and the severity of NAFLD was not considered. Furthermore, the gender impact of sleep duration or sleep quality on NAFLD remains unclear. We thus aimed to examine the association of sleep duration and quality with NAFLD by gender in a Taiwanese population. METHODS: A total of 6663 subjects aged 18 years or more were enrolled...
June 18, 2018: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29929828/erratum-to-%C3%A2-consensus-document-management-of-non-alcoholic-fatty-liver-disease-nafld-clinical-practice-guideline%C3%A2-gastroenterol-hepatol-2018-41-5-328-349
#3
Rocío Aller, Conrado Fernández-Rodríguez, Oreste Lo Iacono, Rafael Bañares, Javier Abad, José Antonio Carrión, Carmelo García-Monzón, Joan Caballería, Marina Berenguer, Manuel Rodríguez-Perálvarez, José López Miranda, Eduardo Vilar-Gómez, Javier Crespo, Miren García-Cortés, María Reig, José María Navarro, Rocío Gallego-Durán, Joan Genescà, María Teresa Arias-Loste, María Jesús Pareja, Agustín Albillos, Jordi Muntané, Francisco Jorquera, Elsa Solà, Manuel Hernández-Guerra, Miguel Ángel Rojo, Javier Salmerón, Llorenc Caballería, Moisés Diago, Esther Molina, Ramón Bataller, Manuel Romero-Gómez
No abstract text is available yet for this article.
June 18, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29929399/the-association-of-non-alcoholic-fatty-liver-disease-and-atrial-fibrillation-a-review
#4
Aki Juhani Käräjämäki, Janne Hukkanen, Olavi Ukkola
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes an enormous burden to human health and health-care systems all over the world. A great proportion of this burden results from increased risk of cardiovascular diseases. Atrial fibrillation (AF) is the most common chronic heart arrhythmia globally and it increases the risk of embolic stroke and heart failure. Recent studies have explored the association between NAFLD and AF with somewhat conflicting results. However, ultrasound-verified prospective studies concur that NAFLD is associated with the incidence of AF...
June 22, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29928260/liver-enlargement-predicts-obstructive-sleep-apnea-hypopnea-syndrome-in-morbidly-obese-women
#5
Giovanna Scartabelli, Giorgia Querci, Letizia Marconi, Giovanni Ceccarini, Paolo Piaggi, Paola Fierabracci, Guido Salvetti, Giovanni Cizza, Salvatore Mazzeo, Jacopo Vitti, Slava Berger, Antonio Palla, Ferruccio Santini
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequently associated in patients with central obesity and metabolic syndrome and are both the result of the accumulation of ectopic fat mass. Identifying predictors of risk of OSAHS may be useful to select the subjects requiring instrumental sleep evaluation. In this cross-sectional study, we have investigated the potential role of hepatic left lobe volume (HLLV) in predicting the presence of OSAHS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29928186/hypothermia-related-acute-pancreatitis
#6
Kyawzaw Lin, Emmanuel Ofori, Aung Naing Lin, Sithu Lin, Thinzar Lin, Ameer Rasheed, Viswanath Vasudevan, Madhavi Reddy
Acute pancreatitis (AP) is an inflammatory disease presenting from mild localized inflammation to severe infected necrotic pancreatic tissue. In the literature, there are a few cases of hypothermia-induced AP. However, the association between hypothermia and AP is still a myth. Generally, mortality from acute pancreatitis is nearly 3-6%. Here, we present a 40-year-old chronic alcoholic female who presented with acute pancreatitis induced by transient hypothermia. A 40-year-old chronic alcoholic female was hypothermic at 81°F on arrival which was improved to 91...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29928018/polymorphisms-in-the-receptor-for-advanced-glycation-end-products-rage-gene-and-circulating-rage-levels-as-a-susceptibility-factor-for-non-alcoholic-steatohepatitis-nash
#7
Rohini Mehta, Gladys Shaw, Peter Masschelin, Sean Felix, Munkzhul Otgonsuren, Ancha Baranova, Zachary Goodman, Zobair Younossi
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and major cause of chronic liver disease in developed countries. Its prevalence is increasing in parallel with the prevalence of obesity and other components of the metabolic syndrome. As the liver is central to the clearance and catabolism of circulating advanced glycosylation end-products (AGEs), AGEs and their cognate receptors-RAGE (receptor for AGEs) system might be involved in NAFLD in obese patients. To examine this, we investigated four common polymorphisms of RAGE gene: 1704G/T (rs184003), G82S (rs2070600), -374T/A (rs1800624) and -429T/C (rs1800625) in 340 obese patients with metabolic syndrome...
2018: PloS One
https://www.readbyqxmd.com/read/29925420/hepatic-steatosis-risk-is-partly-driven-by-increased-de-novo-lipogenesis-following-carbohydrate-consumption
#8
Francis W B Sanders, Animesh Acharjee, Celia Walker, Luke Marney, Lee D Roberts, Fumiaki Imamura, Benjamin Jenkins, Jack Case, Sumantra Ray, Samuel Virtue, Antonio Vidal-Puig, Diana Kuh, Rebecca Hardy, Michael Allison, Nita Forouhi, Andrew J Murray, Nick Wareham, Michele Vacca, Albert Koulman, Julian L Griffin
BACKGROUND: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Here, we investigate whether a sub-set of triacylglycerols (TAGs) were associated with hepatic steatosis and whether they arise from de novo lipogenesis (DNL) from the consumption of carbohydrates. RESULTS: We conduct direct infusion mass spectrometry of lipids in plasma to study the association between specific TAGs and hepatic steatosis assessed by ultrasound and fatty liver index in volunteers from the UK-based Fenland Study and evaluate clustering of TAGs in the National Survey of Health and Development UK cohort...
June 20, 2018: Genome Biology
https://www.readbyqxmd.com/read/29924825/second-harmonic-generation-microscopy-provides-accurate-automated-staging-of-liver-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#9
Pik Eu Chang, George Boon Bee Goh, Wei Qiang Leow, Liang Shen, Kiat Hon Lim, Chee Kiat Tan
BACKGROUND: Assessment of severity of liver fibrosis is essential in the management of non-alcoholic fatty liver disease (NAFLD). Second Harmonic Generation (SHG) microscopy is a novel optical tissue imaging system that provides automated quantification of fibrosis based on unique architectural features of collagen. This study aims to develop and validate a SHG-based index for automated staging of liver fibrosis in patients with NAFLD. METHODS: SHG microscopy was performed on archived liver biopsy specimens from 83 patients with NAFLD...
2018: PloS One
https://www.readbyqxmd.com/read/29924135/exenatide-ameliorates-hepatic-steatosis-and-attenuates-fat-mass-and-fto-gene-expression-through-pi3k-signaling-pathway-in-nonalcoholic-fatty-liver-disease
#10
Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zheng
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29921957/hepatokin1-is-a-biochemistry-based-model-of-liver-metabolism-for-applications-in-medicine-and-pharmacology
#11
Nikolaus Berndt, Sascha Bulik, Iwona Wallach, Tilo Wünsch, Matthias König, Martin Stockmann, David Meierhofer, Hermann-Georg Holzhütter
The epidemic increase of non-alcoholic fatty liver diseases (NAFLD) requires a deeper understanding of the regulatory circuits controlling the response of liver metabolism to nutritional challenges, medical drugs, and genetic enzyme variants. As in vivo studies of human liver metabolism are encumbered with serious ethical and technical issues, we developed a comprehensive biochemistry-based kinetic model of the central liver metabolism including the regulation of enzyme activities by their reactants, allosteric effectors, and hormone-dependent phosphorylation...
June 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29921793/endoplasmic-reticulum-stress-in-metabolic-disorders
#12
REVIEW
Rose Ghemrawi, Shyue-Fang Battaglia-Hsu, Carole Arnold
Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these diseases has different physiological and clinical symptoms, they appear to share certain pathological traits such as intracellular stress and inflammation induced by metabolic disturbance stemmed from over nutrition frequently aggravated by a modern, sedentary life style...
June 19, 2018: Cells
https://www.readbyqxmd.com/read/29921379/the-involvement-and-mechanism-of-febuxostat-in-non-alcoholic-fatty-liver-disease-cells
#13
W Tang, J Mu, Q I Chen, X Li, H Liu
It has been proved that hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD). The xanthine oxidase (XO) inhibitor, febuxostat, decreases free fatty acids-induced fat accumulation in HFDT-fed mice. Here, it is shown that febuxostat attenuates fat accumulation and reactive oxygen species (ROS) in HepG2 cells. It was further found that the underlying mechanism is related to the reduction in expression of NLRP3/caspase-1/IL-18/IL-1beta and improved insulin resistance (IR). This finding highlights the possible molecular pathways involving NLRP3 activation for management of ROS and insulin IR...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29915740/a-study-on-the-altered-glycemic-and-lipid-parameters-and-prevalence-of-insulin-resistance-in-nonalcoholic-fatty-liver-disease
#14
Sangeetha Suresh, Bijayraj Rajanbabu, Vimal Mavila Veetil, Abeed Hussain, Jaseena Nadu Veetil
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a hepatic disorder that develops in the absence of alcohol intake. Obesity and diabetes are considered risk factors for the development of fatty liver; however, whether fatty liver is the cause or consequence of these conditions is not yet clear. Insulin resistance (IR) is found to be a common risk factor for the development of diabetes, obesity and fatty liver. Aims and Objectives: The aim and objective of this study is to determine the prevalence of undetected diabetes, dyslipidemia, and IR in subjects with NAFLD...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915639/a-case-of-concomitant-obstructive-sleep-apnea-and-non-alcoholic-steatohepatitis-treated-with-cpap-therapy
#15
Bharat Bajantri, Dmitry Lvovsky
Obstructive sleep apnea syndrome is a disorder of sleep breathing that is a result of recurrent and intermittent hypoxia during sleep induced by the repeated partial or complete collapse of the upper airway, eventually causing chronic intermittent hypoxia. Non-alcoholic fatty liver disease is divided into non-alcoholic fatty liver and non-alcoholic steatohepatitis. Animal and human studies showed that obesity is associated with chronic liver hypoxia, even in the presence of systemic normoxia causing inflammation and release of cytokines...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29914094/-ganoderma-lucidum-ameliorates-non-alcoholic-steatosis-by-upregulating-energy-metabolizing-enzymes-in-the-liver
#16
Soonwoong Jung, Hyeonwi Son, Chung Eun Hwang, Kye Man Cho, Sang Won Park, Hyun Joon Kim
Non-alcoholic steatosis is a common health problem worldwide due to altered food habits and life styles, and it is intimately linked with various metabolic disorders. In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcoholic steatosis using in vivo and in vitro settings. C57BL/6 mice fed with normal diet (ND) or high fat diet (HFD) were administered GL extract or vehicle for 16 weeks. HFD feeding increased serum alanine aminotransferase level and hepatic lipid droplet, but these increases were significantly attenuated by GL...
June 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29913436/nefa-sensitive-orai1-expression-in-regulation-of-de-novo-lipogenesis
#17
Bingbing Zhang, Wei Yang, Ying Zou, Ming Li, Han Guo, Hongyou Zhang, Cheng Xia, Chuang Xu
BACKGROUND/AIMS: Non-esterified fatty acids (NEFAs) are important inducers of inflammatory responses and hepatic lipid accumulation, which lead to non-alcoholic fatty liver disease (NAFLD). High plasma NEFA is found in NAFLD patients, and associated with metabolic syndrome and type-2 diabetes. NFκB is known to upregulate Orai1, the Ca2+ channel responsible for store-operated Ca2+ entry. The present study explored the role of NEFA-sensitive NFκB-dependent Orai1 expression in the regulation of lipid synthesis...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913275/rates-and-factors-associated-with-placebo-response-in-trials-of-pharmacotherapies-for-nonalcoholic-steatohepatitis-systematic-review-and-meta-analysis
#18
REVIEW
Ma Ai Thanda Han, Osama Altayar, Shadi Hamdeh, Varun Takyar, Yaron Rotman, Ohad Etzion, Eric Lefebvre, Rifaat Safadi, Vlad Ratziu, Larry J Prokop, Mohammad Hassan Murad, Mazen Noureddin
BACKGROUND & AIMS: Understanding the extent of the placebo effect in randomized controlled trials of studying nonalcoholic steatohepatitis (NASH) is important for optimal trial design, including sample size calculations and treatment endpoint definition. METHODS: We performed a systematic review and meta-analysis of the placebo groups from randomized controlled trials of adults with NASH that provided histological and/or magnetic resonance image-based measurements of intrahepatic triglyceride...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29912756/hyperlipidemia-and-nonalcoholic-steatohepatitis-predispose-to-hepatocellular-carcinoma-development-without-cirrhosis
#19
Jennifer Phan, Vivian Ng, Alan Sheinbaum, Sam French, Gina Choi, Mohamed El Kabany, Francisco Durazo, Sammy Saab, Myron Tong, Ronald Busuttil, Steven-Huy Han
BACKGROUND: Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies. With the exception of chronic hepatitis B (CHB), other etiologies of chronic liver disease require progression to cirrhosis before HCC development. Case reports have described HCC in noncirrhotic patients with hepatitis C (HCV) and nonalcoholic fatty liver disease. GOAL: The aim of this study was to determine the prevalence of patients without cirrhosis and CHB who developed HCC among a large cohort of HCC patients and to identify independent variables that are associated with no cirrhosis among patients with HCC...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912573/association-of-tissue-inhibitor-of-metalloproteinase-2-with-non-alcoholic-fatty-liver-disease-in-metabolic-syndrome
#20
Saira Yasmeen, Unab Khan, Ghulam Mustafa Khan, Syeda Sadia Fatima
The aim of this case-control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55 controls were recruited. Anthropometric data, lipid and glucose profile, TIMP2 and liver ultrasound was performed. High TIMP2 was seen in MetS group (145.28 ± 23.11 pg/ml) versus controls (19.06 ± 1.19 pg/ml; p < .001). Serum cholesterol, triglyceride, LDL-c and glucose levels were significantly higher in MetS subjects (p < ...
June 18, 2018: Archives of Physiology and Biochemistry
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