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Haemophilus influenzae

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https://www.readbyqxmd.com/read/28318766/bacille-calmette-gu%C3%A3-rin-bcg-vaccination-at-birth-and-antibody-responses-to-childhood-vaccines-a-randomised-clinical-trial
#1
Thomas Nørrelykke Nissen, Nina Marie Birk, Gaby Smits, Dorthe Lisbeth Jeppesen, Lone Graff Stensballe, Mihai G Netea, Fiona van der Klis, Christine Stabell Benn, Ole Pryds
INTRODUCTION: BCG vaccination has been associated with beneficial non-specific effects on child health. Some immunological studies have reported heterologous effects of vaccines on antibody responses to heterologous vaccines. Within a randomised clinical trial of Bacille Calmette-Guérin (BCG) vaccination at birth, The Danish Calmette Study, we investigated the effect of BCG at birth on the antibody response to the three routine vaccines against DiTeKiPol/Act-Hib and Prevenar 13 in a subgroup of participants...
March 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28301990/risk-factors-for-community-acquired-bacterial-meningitis
#2
Lene Fogt Lundbo, Thomas Benfield
BACKGROUND: Bacterial meningitis is a significant burden of disease and mortality in all age groups worldwide despite the development of effective conjugated vaccines. The pathogenesis of bacterial meningitis is based on complex and incompletely understood host-pathogen interactions. Some of these are pathogen-specific, while some are shared between different bacteria. METHODS: We searched the database PubMed to identify host risk factors for bacterial meningitis caused by the pathogens Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b, because they are three most common causative bacteria beyond the neonatal period...
June 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28301267/hypotonic-hyporesponsive-episodes-after-administration-of-hexavalent-dtp-based-combination-vaccine-a-description-of-12-cases
#3
Alessandro Vigo, Giulia Costagliola, Elisa Ferrero, Silvia Noce
Hypotonic-hyporesponsive (HHE) episodes are known and recognized phenomena, which typically occur within 48 hours of immunisation..Our aim is to describe 12 cases of HHE brought to the Center of Pediatric Sleep Medicine, with attention to the clinical features of the episode and their follow-up. Medical charts of infants visited between 2005-2015 were reviewed. Twelve infants showed a HHE using HHE using Brighton Collaboration Criteria. All infants received a Hexavalent diphtheria -tetanus -pertussis acellular component -hepatitis B-,inactivated poliovirus- Haemophilus influenzae type-b conjugate vaccine...
February 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28298400/antimicrobial-peptide-levels-are-linked-to-airway-inflammation-bacterial-colonisation-and-exacerbations-in-chronic-obstructive-pulmonary-disease
#4
Louise J P Persson, Marianne Aanerud, Jon A Hardie, Roy Miodini Nilsen, Per S Bakke, Tomas M Eagan, Pieter S Hiemstra
Antimicrobial peptides (AMPs) are effectors of host defence against infection, inflammation and wound repair. We aimed to study AMP levels in stable chronic obstructive pulmonary disease (COPD) and during acute exacerbations of COPD (AECOPD), and to examine their relation to clinical parameters and inflammatory markers.The 3-year Bergen COPD Cohort Study included 433 COPD patients and 325 controls. Induced sputum was obtained and analysed for levels of the AMPs human cathelicidin (hCAP18/LL-37) and secretory leukocyte protease inhibitor (SLPI), and for the inflammatory markers interleukin (IL)-8, IL-6 and tumour necrosis factor-α (TNF-α) using immunoassays...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28298381/purulent-pericarditis-as-a-complication-of-bacteraemic-enterococcus-faecalis-urinary-tract-infection
#5
Fredy Nehme, Jane Gitau, Jing Liu
Purulent pericarditis is a rare clinical entity in the modern antibiotic era. The most common portal of entry is thought to be direct extension from a primary lung source and is usually caused by Staphylococcus aureus, Streptococcus pneumoniae or Haemophilus influenzae We report the case of a man aged 69 years who presented with purulent pericarditis due to Enterococcus faecalis likely caused by haematogenous spread from a urinary tract source. Urgent pericardiocentesis was vital and restored his haemodynamic stability...
March 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28298206/burden-and-spectrum-of-bacterial-infections-among-sickle-cell-disease-children-living-in-cameroon
#6
Anastasie Nicole Alima Yanda, Jobert Richie N Nansseu, Hubert Désiré Mbassi Awa, Sandra A Tatah, Judith Seungue, Charlotte Eposse, Paul Olivier N Koki
BACKGROUND: Although sickle cell disease (SCD) children are highly susceptible to bacterial infections (BIs), there is a dreadful lack of data related to the burden and spectrum of BIs in sub-Saharan Africa (SSA), the highest affected region with SCD. This study aimed to determine the burden and spectrum of BIs among SCD children hospitalized in a pediatric reference hospital in Cameroon, a SSA country. METHODS: We conducted a retrospective analysis of records of children hospitalized from November 2012 to August 2015 in the SCD unit of the Mother and Child Centre of the Chantal Biya Foundation, Cameroon...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28288714/bacteria-associated-with-marginal-zone-lymphomas
#7
REVIEW
Maurilio Ponzoni, Andrés J M Ferreri
In the last decades some bacteria have been associated with a various extent with marginal zone (extra nodal, nodal and splenic types) lymphomas are frequently associated with chronic infections, with important clinical, molecular, biological, and therapeutic implications. The well-known correlation between Helicobacter pylori and gastric MALT-lymphoma, the recently reported links between Chlamydia psittaci and ocular adnexal MALT-lymphoma and Borrelia burgdorferi and cutaneous MALT lymphoma constitute the most studied examples; in addition, Campylobacter jejuni and some more recent associations encompassing Achromobacter xylosoxidans and Haemophilus influenzae will be further reported...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28283475/rhinovirus-bacteria-co-exposure-synergistically-induces-ccl20-production-from-human-bronchial-epithelial-cells
#8
Barbara A Maciejewski, Kyla C Jamieson, Jason W Arnason, Cora Kooi, Shahina Wiehler, Suzanne L Traves, Richard Leigh, David Proud
Exacerbations of chronic obstructive pulmonary disease (COPD) are triggered by viral or bacterial pathogens, with human rhinovirus (HRV) and nontypeable Haemophilus influenzae (NTHI) among the most commonly detected pathogens. Patients who suffer from concomitant viral and bacterial infection have more severe exacerbations. The airway epithelial cell is the initial site of viral and bacterial interactions, and CCL20 is an epithelial chemokine that attracts immature dendritic cells to the airways, and can act as an antimicrobial...
March 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28282645/haemophilus-influenzae-isolated-from-men-with-acute-urethritis-its-pathogenic-roles-responses-to-antimicrobial-chemotherapies-and-antimicrobial-susceptibilities
#9
Shin Ito, Kyoko Hatazaki, Ken Shimuta, Hiromi Kondo, Kosuke Mizutani, Mitsuru Yasuda, Keita Nakane, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Makoto Ohinishi, Takashi Deguchi
BACKGROUND: There have been few comprehensive studies on Haemophilus influenza-positive urethritis. METHODS: In this retrospective study, we enrolled 68 men with H. influenzae-positive urethritis, including coinfections with Neisseria gonorrhoeae, Chlamydia trachomatis, and/or genital mycoplasmas: 2, 3, 20, and 43 treated with ceftriaxone, levofloxacin, sitafloxacin, and extended-release azithromycin (azithromycin-SR), respectively. We assessed microbiological outcomes in 54 men and clinical outcomes in 46 with H...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28280296/discharge-and-infection-in-retinoblastoma-post-enucleation-sockets
#10
Daphne L Mourits, Dyonne T Hartong, Andries E Budding, Machteld I Bosscha, H Stevie Tan, Annette C Moll
PURPOSE: To investigate the causes and treatment options for socket discharge and infection in patients enucleated for retinoblastoma (Rb). METHODS: A questionnaire was filled out by (parents of) ocular prosthesis-wearing patients with a history of enucleation as treatment for Rb. We collected data on patients' characteristics, cleaning habits of the prosthesis, frequency of socket irritation, discharge, and infection, and use of antibiotics. With ordinal logistic regression analysis, factors related to the outcome parameters (frequency of irritation, mucoid and purulent discharge) were identified...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28279802/prevention-of-influenza-virus-induced-bacterial-superinfection-by-standardized-echinacea-purpurea-via-regulation-of-surface-receptor-expression-in-human-bronchial-epithelial-cells
#11
Vimalanathan Selvarani, Schoop Roland, Suter Andy, Hudson James
Viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. Such complicated respiratory infections include pneumonia, bronchitis, sinusitis, acute otitis media, and sepsis, which cause high morbidity and lethality. Some of the pathogenic consequences of viral infections, like the expression of bacterial adhesion receptors and the disturbance of physical barrier integrity due to inflammation, may create permissive conditions for co-infections...
March 6, 2017: Virus Research
https://www.readbyqxmd.com/read/28279655/nontypeable-haemophilus-influenzae-promoted-proliferation-of-kras-induced-early-adenomatous-lesions-is-completely-dependent-on-toll-like-receptor-signaling
#12
Christopher Jungnickel, Philipp A Schnabel, Rainer Bohle, Rainer Wiewrodt, Christian Herr, Robert Bals, Christoph Beisswenger
Chronic obstructive pulmonary disease is a risk factor for lung cancer. COPD is characterized by chronic airway inflammation and lung infections. The airways of patients with COPD are frequently colonized with bacteria [eg, nontypeable Haemophilus influenzae (NTHi)] that cause pulmonary inflammation and exacerbations. Pulmonary adenocarcinomas are frequently associated with an activating mutation in the KRAS gene. We determined the function of Toll-like receptor (TLR) signaling on the progression of KRas-induced early adenomatous lesions in the lung...
March 6, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28279319/infective-endocarditis-risk-after-percutaneous-pulmonary-valve-implantation-with-the-melody-and%C3%A2-sapien%C3%A2-valves
#13
Sebastien Hascoet, Lucia Mauri, Caroline Claude, Emmanuelle Fournier, Julie Lourtet, Jean-Yves Riou, Philippe Brenot, Jérôme Petit
OBJECTIVES: This study compared the risk of infective endocarditis (IE) after percutaneous pulmonary valve implantation (PPVI) with the Sapien and Melody valves. BACKGROUND: The incidence of IE after PPVI is estimated at 3% per year with the Melody valve. The Sapien valve is a more recently marketed valve used for PPVI. METHODS: We retrospectively included consecutive patients who underwent PPVI at a single center between 2008 and 2016. IE was diagnosed using the modified DUKE criteria...
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28277801/the-immunogenicity-and-safety-of-a-hib-menac-vaccine-a-non-inferiority-randomized-observer-blind-trial-in-infants-aged-3-5-months
#14
Yu-Xiao Wang, Hong Tao, Jian-Li Hu, Jing-Xin Li, Wei-Ming Dai, Jin-Fang Sun, Pei Liu, Jie Tang, Wen-Yu Liu, Feng-Cai Zhu
BACKGROUND: The objective of this study was to evaluate the immunogenicity and safety of the novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroup A and C-tetanus toxoid conjugate vaccine (Hib-MenAC). RESEARCH DESIGN AND METHODS: We conducted a non-inferiority, randomized, observer-blind, positive control clinical trial in 900 healthy infants aged between 3-5 months in Funing County, Jiangsu Province, China. Participants were randomly allocated, in a ratio of 2:1 (block=6), to receive experimental combined Hib-MenAC vaccines co-administrated with placebo or the co-administration of licensed Hib vaccine and MenAC vaccine, according to a three-dose immunization schedule...
March 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28262704/il-33-st2-immune-responses-to-respiratory-bacteria-in-pediatric-asthma
#15
Isabell Hentschke, Anna Graser, Volker O Melichar, Alexander Kiefer, Theodor Zimmermann, Bettina Kroß, Patricia Haag, Paraskevi Xepapadaki, Nikolaos G Papadopoulos, Christian Bogdan, Susetta Finotto
Here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the EU-wide study PreDicta. In this cohort of pre-school asthmatic children, nasopharyngeal colonization with Gram-negative bacteria such as Haemophilus influenzae and Moraxella catarrhalis was found to be associated with the highest interferon beta (IFNβ) and IL-33 levels in the nasal pharyngeal fluids (NPF). IL33R-ST2 was found induced in the blood of asthmatic children with additional Gram + bacteria in the nasopharynx (Gr+/-)...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261574/persistent-and-recurrent-bacterial-bronchitis-a-paradigm-shift-in-our-understanding-of-chronic-respiratory-disease
#16
REVIEW
Alya Ishak, Mark L Everard
The recent recognition that the conducting airways are not "sterile" and that they have their own dynamic microbiome, together with the rapid advances in our understanding of microbial biofilms and their roles in the causation of respiratory diseases (such as chronic bronchitis, sinusitis, and chronic otitis media), permit us to update the "vicious circle" hypothesis of the causation of bronchiectasis. This proposes that chronic inflammation driven by persistent bacterial bronchitis (PBB) causes damage to both the epithelium, resulting in impaired mucociliary clearance, and to the airway wall, which eventually manifests as bronchiectasis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28260537/characterisation-of-invasive-clinical-haemophilus-influenzae-isolates-in-queensland-australia-using-whole-genome-sequencing
#17
M Staples, R M A Graham, A V Jennison
Haemophilus influenzae is an important aetiological organism of both adult and child respiratory disease. The number of non-typeable (NTHi) invasive H. influenzae isolates referred to the Queensland (QLD) Public Health Microbiology laboratory has increased notably year-by-year. In this study we used whole-genome sequencing to molecularly characterise 100 referred invasive H. influenzae, including 74 NTHi isolates over a 15-year period, observing the carriage of capsular and putative virulence genes, including the major adhesins, antimicrobial resistance genes and population diversity...
March 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28259058/community-analysis-of-dental-plaque-and-endotracheal-tube-biofilms-from-mechanically-ventilated-patients
#18
Poala J Marino, Matt P Wise, Ann Smith, Julian R Marchesi, Marcello P Riggio, Michael A O Lewis, David W Williams
PURPOSE: Mechanically ventilated patients are at risk for developing ventilator-associated pneumonia, and it has been reported that dental plaque provides a reservoir of respiratory pathogens that may aspirate to the lungs and endotracheal tube (ETT) biofilms. For the first time, metataxonomics was used to simultaneously characterize the microbiome of dental plaque, ETTs, and non-directed bronchial lavages (NBLs) in mechanically ventilated patients to determine similarities in respective microbial communities and therefore likely associations...
February 16, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28256375/design-synthesis-and-structure-bactericidal-activity-relationships-of-novel-9-oxime-ketolides-and-reductive-epimers-of-acylides
#19
Jing-Chao Tian, Xu Han, Wei Lv, Ya-Xin Li, Hui Wang, Bing-Zhi Fan, Mark Cushman, Jian-Hua Liang
Erythromycin was long viewed as a bacteriostatic agent. The erythromycin derivatives, 9-oxime ketolides have a species-specific bactericidal profile. Among them, the 3'-allyl version of the 9-oxime ketolide 1 (Ar=3-quinolyl; 17a) is bactericidal against Streptococcus pneumoniae and Streptococcus pyogenes. In contrast, the 2-fluoro analogs of 1, 13a (Ar=6-quinolyl), 13b (Ar=3-quinolyl) and 24a (Ar=4-isoquinolyl), show bactericidal activities against S. pneumoniae, Staphylococcus aureus and Moraxella catarrhalis, while the 2-fluoro analogs 13c (Ar=3-aminopyridyl) and 24b (Ar=3-carbamoylpyridyl) are only bactericidal against S...
April 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28252201/non-typeable-haemophilus-influenzae-infection-of-the-junbo-mouse
#20
Michael T Cheeseman, Derek W Hood
Acute otitis media, inflammation of the middle ear bulla, is the most common bacterial infection in children. For one of the principal otopathogens, non-typeable Haemophilus influenzae (NTHi), animal models allow us to investigate host-microbial interactions relevant to the onset and progression of infection and to study treatment of middle ear disease. We have established a robust model of NTHi middle ear infection in the Junbo mouse. Intranasal inoculation with NTHi produces high rates of bulla infection and high bacterial titers in bulla fluids; bacteria can also spread down the respiratory tract to the mouse lung...
March 2, 2017: Current Protocols in Mouse Biology
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