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https://www.readbyqxmd.com/read/29659889/anti-ebola-virus-antibody-levels-in-convalescent-plasma-and-viral-load-after-plasma-infusion-in-patients-with-ebola-virus-disease
#1
Jerry F Brown, John M Dye, Sam Tozay, Gertrude Jeh-Mulbah, David A Wohl, William A Fischer, Coleen K Cunningham, Kathleen Rowe, Peter Zacharias, James van Hasselt, David A Norwood, Nathan M Thielman, Samantha E Zak, David L Hoover
Background: Ebola virus (EBOV) neutralizing antibody in plasma may reduce viral load following administration of plasma to patients with Ebola virus disease (EVD), but measurement of these antibodies is complex. Methods: Anti-EBOV antibody was measured by two neutralization and two enzyme linked immunosorbent assays (ELISAs) in convalescent plasma (ECP) from 100 EVD survivor donors in Liberia. Viral load was assessed repetitively in patients with EVD participating in a clinical trial of enhanced standard of care plus ECP...
April 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29644234/modelling-coronary-flow-after-the-norwood-operation-influence-of-a-suggested-novel-technique-for-coronary-transfer
#2
Mohammed K Al-Jughiman, Maryam A Al-Omair
Background: The dynamic behavior of the aortic sinuses has an important function in the specific characteristics of coronary blood flow. Several publications have confirmed suboptimal myocardial perfusion after the Norwood procedure. Our study was undertaken to confirm four hypotheses. First, we hypothesized that there is more resistance to coronary flow due to coronary attachments to hypoplastic aortic root and sinuses. Also, as the amalgamation of the ascending aorta with the pulmonary artery occurs above the aortic root, the coronary blood flow is not fully in antegrade pattern...
March 14, 2018: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29617791/beating-heart-aortic-arch-surgery-in-neonates-and-infants
#3
Juan-Miguel Gil-Jaurena, María-Teresa González-López, Ana Pita, Ramón Pérez-Caballero, Mónica Herviás, Dorotea Blanco
OBJECTIVES: Aortic arch repair has been shifted from deep hypothermia plus circulatory arrest to cerebral perfusion at tepid temperatures. A step forward is a simultaneous brain-coronary perfusion, allowing beating-heart arch surgery. METHODS: A 'Y' cannula from the arterial line delivers oxygenated blood to brain and heart. The arch is repaired on a beating heart at 25°C. Intracardiac repair is performed after running cardioplegia through the root line. Fifty patients are classified into 3 groups: A, Norwood (8 neonates); B, aortic arch (14 children) and C, aortic arch plus intracardiac repair (28 patients)...
April 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29580723/the-performance-of-a-zirconium-based-root-filling-material-with-artifact-reduction-properties-in-the-detection-of-artificially-induced-root-fractures-using-cone-beam-computed-tomographic-imaging
#4
Aaron Fox, Bettina Basrani, Ernest W N Lam
INTRODUCTION: Limited field of view cone-beam computed tomographic (CBCT) imaging has been used to augment clinical testing of vertical root fractures (VRFs); however, the presence of gutta-percha (GP) in the canal space generates substantial imaging artifacts that make fracture detection difficult. The purpose of this study was to evaluate the influence of a zirconium (Zr)-based root filling material with radiologic properties that reduce beam hardening (BH) artifacts using CBCT imaging in the in vitro diagnosis of VRFs...
March 23, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29577004/staged-surgical-palliation-for-hlhs-in-a-girl-with-severe-factor-x-deficiency
#5
Ahmed F Elmahrouk, Mohamed F Ismail, Abdulbadee Bugis, Nashwa Badawy, Hesham Mohamed Aboelghar, Tamer Hamouda, Ahmed Jamjoom
Background  Factor X deficiency (also known as Stuart-Prower factor deficiency) is an autosomal recessive extremely rare hereditary hematologic disorder, affecting around 1:1,000,000 of the general population. Case Presentation  This case report describes a patient with hypoplastic left heart syndrome and severe factor X deficiency, who underwent staged surgical palliation. From stage 1 Norwood palliation, through superior cavopulmonary anastomosis and ending with total cavopulmonary connection with satisfactory hemostasis and no significant perioperative bleeding complication...
January 2018: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/29571602/heart-failure-after-the-norwood-procedure-an-analysis-of-the-single-ventricle-reconstruction-trial
#6
William T Mahle, Chenwei Hu, Felicia Trachtenberg, JonDavid Menteer, Steven J Kindel, Anne I Dipchand, Marc E Richmond, Kevin P Daly, Heather T Henderson, Kimberly Y Lin, Michael McCulloch, Ashwin K Lal, Kurt R Schumacher, Jeffrey P Jacobs, Andrew M Atz, Chet R Villa, Kristin M Burns, Jane W Newburger
BACKGROUND: Heart failure results in significant morbidity and mortality in young children with hypoplastic left heart syndrome (HLHS) after the Norwood procedure. METHODS: We studied subjects enrolled in the prospective Single Ventricle Reconstruction (SVR) Trial who survived to hospital discharge after a Norwood operation and were followed up to age 6 years. The primary outcome was heart failure, defined as heart transplant listing after Norwood hospitalization, death attributable to heart failure, or symptomatic heart failure (New York Heart Association [NYHA] Class IV)...
February 16, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29554209/introducing-platelet-rich-stroma-platelet-rich-plasma-prp-and-stromal-vascular-fraction-svf-combined-for-the-treatment-of-androgenetic-alopecia
#7
Hieronymus P Stevens, Simone Donners, Julia de Bruijn
Background: Androgenetic alopecia (AGA) is characterized by miniaturization of the hair follicles gradually causing conversion of terminal hairs into vellus hairs, leading to progressive reduction of the density of hair on the scalp. Approved therapeutic options are limited and show side effects. Objectives: To evaluate injections of stromal vascular fraction (SVF), which is rich in adipose-derived stromal cells (ASCs) in combination with platelet-rich plasma (PRP) in the upper scalp as a new autologous treatment option for AGA...
March 15, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29546398/novel-aortic-arch-reconstruction-using-a-modified-norwood-procedure-based-on-hypoplastic-left-heart-syndrome-specific-anatomical-malformations
#8
Takeshi Konuma, Syunsuke Sakamoto, Syuhei Toba, Ayano Futsuki, Naoki Yamamoto, Shinji Kanemitsu, Hideto Shimpo
OBJECTIVES: Postoperative left pulmonary artery (PA) or bronchus compression occasionally follows narrowing of the retroaortic space after the Norwood procedure. We examined hypoplastic left heart syndrome (HLHS)-specific anatomical malformations and hypothesized that a long main pulmonary arterial trunk might contribute to a larger retroaortic space. In this study, we introduced a modified Norwood procedure [pulmonary artery trunk-saving method (PATS)] and evaluated the results. METHODS: HLHS-specific anatomical malformations were examined using computed tomographic data from 23 consecutive patients who underwent bilateral pulmonary banding...
March 12, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29544421/early-outcomes-of-hypoplastic-left-heart-syndrome-infants-meta-analysis-of-studies-comparing-the-hybrid-and-norwood-procedures
#9
Jacob Y Cao, Seung Yeon Lee, Kevin Phan, Julian Ayer, David S Celermajer, David S Winlaw
The hybrid strategy is an alternative to the traditional Norwood procedure for initial palliation of infants with hypoplastic left heart syndrome (HLHS) who are deemed to be at high surgical risk. Numerous single-center studies have compared the two procedures, showing similar early outcomes, although the cohort sizes are likely insufficiently powered to detect significant differences. The current meta-analysis aims to explore the early morbidity and mortality associated with the hybrid compared to the Norwood procedure...
March 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29534446/chemotherapeutic-induced-cardiovascular-dysfunction-physiological-effects-early-detection-the-role-of-telomerase-to-counteract-mitochondrial-defects-and-oxidative-stress
#10
REVIEW
Nabeel Quryshi, Laura E Norwood Toro, Karima Ait-Aissa, Amanda Kong, Andreas M Beyer
Although chemotherapeutics can be highly effective at targeting malignancies, their ability to trigger cardiovascular morbidity is clinically significant. Chemotherapy can adversely affect cardiovascular physiology, resulting in the development of cardiomyopathy, heart failure and microvascular defects. Specifically, anthracyclines are known to cause an excessive buildup of free radical species and mitochondrial DNA damage (mt DNA) that can lead to oxidative stress-induced cardiovascular apoptosis. Therefore, oncologists and cardiologists maintain a network of communication when dealing with patients during treatment in order to treat and prevent chemotherapy-induced cardiovascular damage; however, there is a need to discover more accurate biomarkers and therapeutics to combat and predict the onset of cardiovascular side effects...
March 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29527923/hiv-testing-prevalence-in-selected-chicago-community-areas-the-importance-of-local-level-data
#11
Bijou R Hunt, Charlotte Picard, Jana L Hirschtick, Nancy Glick
While data on HIV testing prevalence is readily available at the national, state, and more rarely at the city level, few data are available on HIV testing at the community level, where public health initiatives may be most effectively implemented. Community-level data are necessary given that city, state, and national estimates mask variation occurring at the community level in large urban areas. This type of data is crucial for informing education efforts both within the community and among providers. The current study uses the Sinai Community Health Survey 2...
March 7, 2018: AIDS Care
https://www.readbyqxmd.com/read/29524308/differences-in-midterm-outcomes-in-infants-with-hypoplastic-left-heart-syndrome-diagnosed-with-necrotizing-enterocolitis-npcqic-database-analysis
#12
Natasha L Lopez, Charitha Gowda, Carl H Backes, Deipanjan Nandi, Holly Miller-Tate, Samantha Fichtner, Robin Allen, Jamie Stewart, Clifford L Cua
INTRODUCTION: Neonates with hypoplastic left heart syndrome (HLHS) are at increased risk for necrotizing enterocolitis (NEC). Initial hospital outcomes are well described, but minimal midterm data exist. Goal of this study was to compare outcomes of HLHS infants with NEC (HLHS-NEC) to HLHS without NEC (HLHS-nNEC) during the interstage period. METHODS: Data were reviewed from 55 centers using the NPC-QIC database. Case-control study with one HLHS-NEC matched to HLHS-nNEC neonates in a 1:3 ratio based on institutional site, type of surgical repair, and gestational age ±1 week was performed...
March 9, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29523921/impact-of-hybrid-stage-1-palliation-for-hypoplastic-left-heart-syndrome-histopathological-findings
#13
Takashi Kido, Takaya Hoashi, Masataka Kitano, Masatoshi Shimada, Kenichi Kurosaki, Hatsue Ishibashi-Ueda, Hajime Ichikawa
The purpose of the study is to analyze the impact of hybrid stage 1 palliation on right ventricular myocardial pathology in hypoplastic left heart syndrome. Sufficient amount of right ventricular biopsies could be obtained from 16 of 32 patients who underwent Norwood operation between 2007 and 2013. Histopathological findings of right ventricle in patients who underwent primary Norwood operation (primary group, n = 5), patients with aortic atresia (HS1P AA group, n = 6) or aortic stenosis (HS1P AS group, n = 5) who underwent staged Norwood palliation following hybrid stage 1 palliation were compared...
March 9, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29520465/survival-to-stage-ii-with-ventricular-dysfunction-secondary-analysis-of-the-single-ventricle-reconstruction-trial
#14
Emilie Jean-St-Michel, James M Meza, Jonathon Maguire, John Coles, Brian W McCrindle
Ventricular dysfunction affects survival in patients with single right ventricle (RV), and remains one of the primary indications for heart transplantation. Since it is challenging to predict the capacity of patients with ventricular dysfunction to proceed to the stage II procedure, we sought to identify factors that would be associated with death or heart transplantation without achieving stage II for single RV patients with ventricular dysfunction after Norwood procedure. The Single Ventricle Reconstruction (SVR) trial public-use database was used...
March 8, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29510943/laryngeal-ultrasound-detects-a-high-incidence-of-vocal-cord-paresis-after-aortic-arch-repair-in-neonates-and-young-children
#15
Melissa G Y Lee, Johnny Millar, Elizabeth Rose, Aleesha Jones, Dora Wood, Taryn L Luitingh, Diana Zannino, Johann Brink, Igor E Konstantinov, Christian P Brizard, Yves d'Udekem
OBJECTIVES: To determine the incidence of vocal cord paresis (VCP) after neonatal aortic arch repair/Norwood-type procedure, and the effectiveness of noninvasive laryngeal ultrasound in detecting VCP compared with gold standard invasive nasoendoscopy. METHODS: Fifty-two patients who underwent an arch repair (39 of 52; 75%) or Norwood-type procedure (13 of 52; 25%) via sternotomy between April 1, 2015, and April 30, 2017 underwent laryngeal ultrasound (50 of 52; 96%) and/or flexible fiber optic nasoendoscopy (39 of 52; 75%) at 48 to 72 hours after endotracheal extubation...
February 9, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29508077/acute-kidney-injury-is-associated-with-subsequent-infection-in-neonates-after-the-norwood-procedure-a-retrospective-chart-review
#16
Megan SooHoo, Benjamin Griffin, Anna Jovanovich, Danielle E Soranno, Emily Mack, Sonali S Patel, Sarah Faubel, Katja M Gist
BACKGROUND: Acute kidney injury (AKI) and infection are common complications after pediatric cardiac surgery. No pediatric study has evaluated for an association between postoperative AKI and infection. The objective of this study was to determine if AKI in neonates after cardiopulmonary bypass was associated with the development of a postoperative infection. METHODS: We performed a single center retrospective chart review from January 2009 to December 2015 of neonates (age ≤ 30 days) undergoing the Norwood procedure...
March 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29506588/rationalising-the-use-of-cardiac-catheterisation-before-glenn-completion
#17
Lorraine James, Animesh Tandon, Alan Nugent, Sadia Malik, Claudio Ramaciotti, Gerald Greil, Luis Zabala, Joseph Forbess, Tarique Hussain
Previous studies have shown that cardiac MRI can be used to evaluate the suitability for infants to undergo the Glenn operation after having undergone the Norwood procedure. We sought to analyse our institutional data retrospectively to identify whether such a policy would be advisable in the current era. We reviewed patients who underwent the Norwood procedure between 1 January, 2006 and 1 January, 2016. All patients undergoing evaluation for the Glenn procedure received clinical evaluation, echocardiography, and cardiac catheterisation...
March 6, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29460509/study-of-the-efficacy-of-carboxytherapy-in-alopecia
#18
Noha Nabil Doghaim, Rania Ahmed El-Tatawy, Yomna Mazid El-Hamd Neinaa, Marwa Mohsen Abd El-Samd
BACKGROUND: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challenging. The use of carboxytherapy may be a novel therapeutic option for such cases. OBJECTIVE: To evaluate the clinical efficacy and safety of carboxytherapy in alopecia areata and androgenetic alopecia. PATIENTS AND METHODS: This study was conducted on 80 patients with alopecia divided into two groups; Group I included 40 AA patients (Group IA received carboxytherapy and Group IB control received placebo), and Group II included 40 AGA patients (Group IIA received carboxytherapy and Group IIB control received placebo), and followed up monthly for 3 months...
February 20, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29452118/long-term-outcome-of-interrupted-arch-repair-with-direct-anastomosis-and-homograft-augmentation-patch
#19
Mohammed Mohsin Uzzaman, Natasha E Khan, Ben Davies, John Stickley, Timothy J Jones, William J Brawn, David J Barron
BACKGROUND: We analysed outcomes of IAA repair using a standardised technique in order to interpret the role of the arch repair on late outcomes in this complex and heterogeneous group. METHODS: Single institution study from 1988-2015. 120 cases of IAA were divided into four groups: IAA with VSD (iVSD, n=38), IAA with Norwood/DKS (iNor, n=41), IAA with Truncus (iTruncus, n=24) and miscellaneous group (iMisc, n=17). Arch repair performed using a standard technique of direct anastomosis with homograft patch augmentation...
February 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29448010/improved-outcomes-in-management-of-hypoplastic-left-heart-syndrome-associated-with-congenital-diaphragmatic-hernia-an-algorithmic-approach
#20
Kaitlin Balduf, T K Susheel Kumar, Umar Boston, Shyam Sathanandam, Marc V Lee, Tim Jancelewicz, Christopher J Knott-Craig
Hypoplastic left heart syndrome (HLHS) is the second most common congenital heart disease associated with congenital diaphragmatic hernia (CDH). The reported survival rate of neonates with CDH and HLHS is only 1%-5%. We review our experience with CDH and HLHS and compare our outcomes with published literature. Retrospective review of all neonates with CDH and HLHS at our institution over a 10-year period was performed. The morphology of cardiac and diaphragm defects, clinical course, treatment strategies, and outcomes were reviewed, and an algorithmic approach was proposed...
February 12, 2018: Seminars in Thoracic and Cardiovascular Surgery
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