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https://www.readbyqxmd.com/read/29444035/power-scalable-10%C3%A2-%C3%A2-w-976%C3%A2-%C3%A2-nm-single-frequency-linearly-polarized-laser-source
#1
Jingwei Wu, Xiushan Zhu, Hua Wei, Kort Wiersma, Michael Li, Jie Zong, Arturo Chavez-Pirson, Valery Temyanko, L J LaComb, R A Norwood, N Peyghambarian
A 10 W level 976 nm single-frequency linearly polarized laser source was demonstrated with a two-stage all-fiber amplifier configuration. The continuous-wave output power of 10.1 W was obtained from the second stage amplifier by using a 20/130 μm single-mode, polarization maintaining, 1.5 wt. % ytterbium-doped phosphate double-clad fiber. This all-fiber single-frequency laser source is very promising for watt-level deep ultraviolet laser generation via frequency quadrupling.
February 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29440831/prognostic-value-of-troponin-in-infants-with-hypoplastic-left-heart-syndrome-between-stage-i-and-ii-of-palliation
#2
Martin Christmann, Emanuela R Valsangiacomo Büchel, Hitendu Dave, Dietrich Klauwer, Anna Cavigelli-Brunner
Background: The period between stage I and II procedure for treatment of hypoplastic left heart syndrome (HLHS) bears high mortality and morbidity. Methods: We sought to analyze the prognostic value of Troponin T/I (Trop), a well-recognized marker for myocardial damage and heart failure, for predicting outcome in a retrospective analysis of 70 infants with HLHS at our institution between March 2001 and October 2014. Results: Stage I procedure consisted of Norwood I operation in 35 (50%) and Hybrid-approach in 22 (31%) patients...
January 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29437916/mobility-shift-of-beta-dystroglycan-as-a-marker-of-gmppb-gene-related-muscular-dystrophy
#3
Anna Sarkozy, Silvia Torelli, Rachael Mein, Matt Henderson, Rahul Phadke, Lucy Feng, Caroline Sewry, Pierpaolo Ala, Michael Yau, Marta Bertoli, Tracey Willis, Simon Hammans, Adnan Manzur, Maria Sframeli, Fiona Norwood, Wojtek Rakowicz, Aleksandar Radunovic, Sujit S Vaidya, Matt Parton, Mark Walker, Silvia Marino, Curtis Offiah, Maria Elena Farrugia, Godwin Mamutse, Chiara Marini-Bettolo, Elizabeth Wraige, David Beeson, Hanns Lochmüller, Volker Straub, Kate Bushby, Rita Barresi, Francesco Muntoni
BACKGROUND: Defects in glycosylation of alpha-dystroglycan (α-DG) cause autosomal-recessive disorders with wide clinical and genetic heterogeneity, with phenotypes ranging from congenital muscular dystrophies to milder limb girdle muscular dystrophies. Patients show variable reduction of immunoreactivity to antibodies specific for glycoepitopes of α-DG on a muscle biopsy. Recessive mutations in 18 genes, including guanosine diphosphate mannose pyrophosphorylase B ( GMPPB ), have been reported to date...
February 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29432890/risk-factors-for-gastrostomy-tube-placement-in-single-ventricle-patients-following-the-norwood-procedure
#4
Kurt D Piggott, Jaqueline Babb, Sylvia Yong, Harun Fakioglu, Carlos Blanco, William DeCampli, Kamal Pourmoghadam
OBJECTIVES: Neonates with single ventricle heart disease frequently suffer from poor oral feeding and inconsistent weight gain, often requiring gastrostomy tube (gtube) placement. We sought to identify risk factors for g-tube placement in neonates following the Norwood procedure at our institution. METHODS: We retrospectively reviewed multiple preoperative, operative and postoperative variables in neonates <30 days with single ventricle heart disease following the Norwood procedure...
February 9, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29432364/per-ventricular-insertion-of-melody-valve-in-valve-in-the-neoaortic-position-in-a-single-ventricle-patient
#5
Nicholas S Clarke, Howaida El-Said, John J Lamberti, Raghav A Murthy
Percutaneous therapies for congenital heart disease have been evolving rapidly despite limited investment from industry. The Melody transcatheter pulmonary valve (Medtronic, Inc, Minneapolis, MN USA) replacement therapy represents an important advancement in this arena. It has been approved in the United States for use in the pulmonary position, on a Humanitarian Device Exemption status. Off-label use of the Melody transcatheter pulmonary valve has extended to the mitral, pulmonary, and aortic valves, especially in previously implanted valves with prosthetic valve degeneration...
February 9, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29430429/extracardiac-conduit-fontan-operation-with-reduction-aortoplasty-for-left-pulmonary-artery-compression-after-a-norwood-procedure-in-a-patient-with-double-inlet-left-ventricle
#6
Jae Won Song, Woong Han Kim, Jae Gun Kwak, Ji Young Park
Patients with double-inlet left ventricle usually have a small ascending aorta. In the Norwood procedure, which involves a staged operation, a neoaorta is constructed with a homograft, and the pulmonary artery plays a role in the systemic circulation. Dilatation or aneurysmal changes can occur over time due to the exposure of the neoaorta to systemic pressure, which may induce adverse effects on adjacent structures. We report a rare case of surgical repair for neoaortic root dilataiton with aortic regurgitation, compressing the left pulmohary artery, in a patient who underwent the Norwood procedure...
February 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29427252/comparison-of-measures-of-adiposity-and-cardiovascular-disease-risk-factors-among-african-american-adults-the-jackson-heart-study
#7
Ronny A Bell, Haiying Chen, Santiago Saldana, Alain G Bertoni, Valery S Effoe, Kristen G Hairston, Rita R Kalyani, Arnita F Norwood
Obesity, particularly central adiposity, is a well-established risk factor for cardiovascular disease (CVD). Waist circumference (WC) is measured in numerous epidemiologic studies as a relatively simple indicator of central adiposity. However, recently, investigators have considered a measure that takes height into consideration, waist-to-height ratio (WHtR) as a more sensitive predictor of CVD. A limited number of studies have examined the association between various measures of central adiposity and obesity with CVD, but there is a dearth of information on this topic focused specifically on African American adults...
February 9, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29420218/neighborhood-socioeconomic-status-and-outcomes-following-the-norwood-procedure-an-analysis-of-the-pediatric-heart-network-single-ventricle-reconstruction-trial-public-data-set
#8
Emily M Bucholz, Lynn A Sleeper, Jane W Newburger
BACKGROUND: Children with single ventricle heart disease require frequent interventions and follow-up. Low socioeconomic status (SES) may limit access to high-quality care and place these children at risk for poor long-term outcomes. METHODS AND RESULTS: Data from the SVR (Pediatric Heart Network Single Ventricle Reconstruction Trial Public Use) data set were used to examine the relationship of US neighborhood SES with 30-day and 1-year mortality or cardiac transplantation and length of stay among neonates undergoing the Norwood procedure (n=525)...
February 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29420123/talimogene-laherparepvec-first-in-class-oncolytic-virotherapy
#9
Robert M Conry, Brian Westbrook, Svetlana McKee, Timothy Graham Norwood
Oncolytic viruses represent a novel drug class in which native or modified viruses mediate tumor regression through selective replication within and lysis of tumor cells as well as induction of systemic antitumor immunity capable of eradicating tumor at distant, uninjected sites. Talimogene laherparepvec (TVEC) is a type I herpes simplex virus genetically modified to preferentially replicate in tumor cells, enhance antigen loading of MHC class I molecules and express granulocyte-macrophage colony-stimulating factor to increase tumor-antigen presentation by dendritic cells...
February 8, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29419407/hyperoxia-causes-mitochondrial-fragmentation-in-pulmonary-endothelial-cells-by-increasing-expression-of-pro-fission-proteins
#10
Cui Ma, Andreas M Beyer, Matthew Durand, Anne V Clough, Daling Zhu, Laura Norwood Toro, Maia Terashvili, Johnathan D Ebben, R Blake Hill, Said H Audi, Meetha Medhora, Elizabeth R Jacobs
OBJECTIVE: We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. APPROACH AND RESULTS: Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and mitochondrial fragmentation quantified. Expression of pro-fission or fusion proteins or autophagy-related proteins were assessed by Western blot. Mitochondrial oxidative state was determined using mito-roGFP. Tetramethylrhodamine methyl ester estimated mitochondrial polarization in treatment groups...
February 1, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29407078/long-term-survival-of-hypoplastic-left-heart-syndrome-infants-meta-analysis-comparing-outcomes-from-the-modified-blalock-taussig-shunt-and-the-right-ventricle-to-pulmonary-artery-shunt
#11
Jacob Y Cao, Kevin Phan, Julian Ayer, David S Celermajer, David S Winlaw
BACKGROUND: Stage 1 palliation of hypoplastic left heart syndrome (HLHS) involves the Norwood procedure combined with a modified Blalock-Taussig shunt (mBTS) or right ventricle to pulmonary artery shunt (RVPAS). Short-term survival has been described previously, whereas longer-term outcomes remain a subject of debate. This meta-analysis aimed to describe the short and long-term survival outcomes of these two shunts, and explore factors that might influence survival. METHODS: Medline, Cochrane Libraries and EMBASE were systematically searched, and 32 studies were included for statistical synthesis, comprising 1348 mBTS and 1258 RVPAS patients...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29388886/measuring-intention-to-refer-older-adults-and-social-service-agencies
#12
Dwight L Norwood, Brenda Kurz
The public is encouraged to engage in socially responsible behaviors such as helping people get needed services, possibly by referring them. However, referral behavior is little researched. Informed by the Theory of Planned Behavior, intent to refer older adults in need to the Connecticut's Gatekeeper Program (GP) which identifies elders at risk and connects them with community resources was studied and the Social Service Agency Referral Scale (SSARS) was developed. Senior center attendees, seniors who received GP training, and referrers to the state's GP were involved...
February 1, 2018: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/29378757/systemic-right-ventricle-in-adults-with-congenital-heart-disease-anatomic-and-phenotypic-spectrum-and-current-approach-to-management
#13
REVIEW
Margarita Brida, Gerhard-Paul Diller, Michael A Gatzoulis
The systemic right ventricle (SRV) is commonly encountered in congenital heart disease representing a distinctly different model in terms of its anatomic spectrum, adaptation, clinical phenotype, and variable, but overall guarded prognosis. The most common clinical scenarios where an SRV is encountered are complete transposition of the great arteries with previous atrial switch repair, congenitally corrected transposition of the great arteries, double inlet right ventricle mostly with previous Fontan palliation, and hypoplastic left heart syndrome palliated with the Norwood-Fontan protocol...
January 30, 2018: Circulation
https://www.readbyqxmd.com/read/29370912/norwood-valved-sano-shunt-early-reward-versus-late-penalty
#14
EDITORIAL
Sameh M Said, Joseph A Dearani
No abstract text is available yet for this article.
January 6, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29350395/early-results-of-aortic-arch-reconstruction-and-bilateral-pulmonary-arteries-banding-modification-of-the-norwood-operation-for-treatment-of-hypoplastic-left-heart-syndrome
#15
Jacek W Pająk, Michał Buczyński, Piotr Stanek, Grzegorz Zalewski, Marek Wites, Lesław Szydłowski, Lidia Tomkiewicz-Pająk
BACKGROUND: In the period from 2003 to the end of 2015, 96 Norwood I procedures were performed in Pediatric Heart Surgery Department in Katowice, Poland, in children with hypoplastic left heart syndrome (HLHS). AIM: This paper presents a retrospective analysis of early surgical results. METHODS: The patients consisted of two groups: Group I included 59 children operated on in the years 2003-2012 in whom the stage I Norwood procedure with the Sano modification was performed with the aortic arch reconstructed by use of a homogenous pulmonary artery patch or a bovine pericardial patch...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29342174/preference-evaluation-of-ground-beef-by-untrained-subjects-with-three-levels-of-finely-textured-beef
#16
Sandra Molly Depue, Morgan Marie Neilson, Jayson L Lusk, Gretchen Mafi, F Bailey Norwood, Ranjith Ramanathan, Deborah VanOverbeke
After receiving bad publicity in 2012 and being removed from many ground beef products, finely textured beef (referred to as 'pink slime' by some) is making a comeback. Some of its proponents argue that consumers prefer ground beef containing finely textured beef, but no objective scientific party has tested this claim-that is the purpose of the present study. Over 200 untrained subjects participated in a sensory analysis in which they tasted one ground beef sample with no finely textured beef, another with 15% finely textured beef (by weight), and another with more than 15%...
2018: PloS One
https://www.readbyqxmd.com/read/29337121/the-society-of-thoracic-surgeons-congenital-heart-surgery-database-2018-update-on-outcomes-and-quality
#17
Jeffrey P Jacobs, John E Mayer, Sara K Pasquali, Kevin D Hill, David M Overman, James D St Louis, S Ram Kumar, Carl L Backer, Charles D Fraser, James S Tweddell, Marshall L Jacobs
The Society of Thoracic Surgeons Congenital Heart Surgery Database is a comprehensive clinical outcomes registry which captures almost all pediatric cardiac surgical operations in the United States. It is the platform for all activities of The Society of Thoracic Surgeons related to the analysis of outcomes and the improvement of quality in this subspecialty. This article summarizes current aggregate national outcomes in congenital and pediatric cardiac surgery and reviews related activities in the areas of quality measurement, performance improvement, and transparency...
January 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29335482/engineered-nonlinear-materials-using-gold-nanoantenna-array
#18
Vladimir P Drachev, Alexander V Kildishev, Joshua D Borneman, Kuo-Ping Chen, Vladimir M Shalaev, Konstantin Yamnitskiy, Robert A Norwood, Nasser Peyghambarian, Seth R Marder, Lazaro A Padilha, Scott Webster, Trenton R Ensley, David J Hagan, Eric W Van Stryland
Gold dipole nanoantennas embedded in an organic molecular film provide strong local electromagnetic fields to enhance both the nonlinear refractive index (n2) and two-photon absorption (2PA) of the molecules. An enhancement of 53× for 2PA and 140× for nonlinear refraction is observed for BDPAS (4,4'-bis(diphenylamino)stilbene) at 600 nm with only 3.7% of gold volume fraction. The complex value of the third-order susceptibility enhancement results in a sign change of n2 for the effective composite material relative to the pure BDPAS film...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325163/trans-ethnic-evaluation-identifies-novel-low-frequency-loci-associated-with-25-hydroxyvitamin-d-concentrations
#19
Jaeyoung Hong, Kathryn E Hatchell, Jonathan P Bradfield, Bjonnes Andrew, Chesi Alessandra, Lai Chao-Qiang, Carl D Langefeld, Lingyi Lu, Yingchang Lu, Pamela L Lutsey, Solomon K Musani, Mike A Nalls, Cassianne Robinson-Cohen, Jeffery D Roizen, Richa Saxena, Katherine L Tucker, Julie T Ziegler, Dan E Arking, Joshua C Bis, Eric Boerwinkle, Erwin P Bottinger, Donald W Bowden, Vincente Gilsanz, Denise K Houston, Heidi J Kalkwarf, Andrea Kelly, Joan M Lappe, Yongmei Liu, Erin D Michos, Sharon E Oberfield, Nicholette D Palmer, Jerome I Rotter, Bishwa Sapkota, John A Shepherd, James G Wilson, Saonli Basu, Ian H de Boer, Jasmin Divers, Barry I Freedman, Struan F A Grant, Hakon Hakanarson, Tamara B Harris, Bryan R Kestenbaum, Stephen B Kritchevsky, Ruth J F Loos, Jill M Norris, Arnita F Norwood, Jose M Ordovas, James S Pankow, Bruce M Psaty, Dharambir K Sanhgera, Lynne E Wagenknecht, Babette S Zemel, James Meigs, Josée Dupuis, Jose C Florez, Thomas Wang, Ching-Ti Liu, Corinne D Engelman, Liana K Billings
Context: Vitamin D inadequacy is common in the adult population of the United States. While the genetic determinants underlying vitamin D inadequacy have been studied in people of European ancestry, less is known in Hispanic or African ancestry populations. Objective: The TRANSCEN-D (TRANS-ethniC Evaluation of vitamiN D GWAS) consortium was assembled to replicate genetic associations with 25-hydroxyvitamin D (25(OH)D) concentrations from the meta-analyses of European ancestry (SUNLIGHT) and to identify novel genetic variants related to vitamin D concentrations in African and Hispanic ancestries...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29301696/heat-acclimation-causes-a-linear-decrease-in-sweat-sodium-ion-concentration
#20
Michael J Buono, Mark Kolding, Eric Leslie, Daniel Moreno, Sarah Norwood, Andrew Ordille, Rebecca Weller
The purpose of this study was to determine the time course for the previously reported reduction in sweat sodium ion concentration during heat acclimation. Four healthy volunteers completed 7 consecutive days of heat acclimation which included 2h of treadmill walking in a 40°C and 40% relative humidity environment. A modified constant hyperthermia protocol was used as workloads were increased each day to maintain a constant core temperature over the 7 days of heat acclimation. Forearm sweat was collected 3 times during each 2h exercise bout on days 1, 3, 5, and 7 of heat acclimation...
January 2018: Journal of Thermal Biology
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