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Reticulated platelets

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https://www.readbyqxmd.com/read/29720539/its-reticulated-the-liver-at-the-heart-of-atherosclerosis
#1
Prabhakara R Nagareddy, Sunil K Noothi, Michelle Christine Flynn, Andrew Murphy
Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications. Low-dose aspirin remains the mainstay of antiplatelet therapy in high-risk patients by reducing the risk of myocardial ischemia (MI), stroke, or death due to cardiovascular disease (CVD). However, antiplatelet therapies lose their efficacy in people with diabetes mellitus (DM), increasing the risk of future atherothrombotic events. The molecular mechanisms that promote platelet hyperactivity remain unclear but could be due to glycation-induced conformational changes of platelet membranes resulting in impaired aspirin entry, or less-efficient acetylation/compensatory increase in COX-2 expression in newborn platelets...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29666579/d-dencichine-regulates-thrombopoiesis-by-promoting-megakaryocyte-adhesion-migration-and-proplatelet-formation
#2
Shilan Ding, Min Wang, Song Fang, Huibo Xu, Huiting Fan, Yu Tian, Yadong Zhai, Shan Lu, Xin Qi, Fei Wei, Guibo Sun, Xiaobo Sun
Life-threatening chemotherapy-induced thrombocytopenia can increase the risk of bleeding due to a dramatic low platelet count, which may limit or delay treatment schedules in cancer patients. The pressing need for the rapid alleviation of the symptoms of thrombocytopenia has prompted us to search for novel highly effective and safe thrombopoietic agents. Pharmacological investigations have indicated that dencichine can prevent and treat blood loss and increase the number of platelets. On the basis of the neurotoxicity of dencichine, D-dencichine is artificially synthesized in the laboratory...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29476243/increased-platelet-count-and-reticulated-platelets-in-recently-symptomatic-versus-asymptomatic-carotid-artery-stenosis-and-in-cerebral-microembolic-signal-negative-patient-subgroups-results-from-the-haemostasis-in-carotid-stenosis-heist-study
#3
S J X Murphy, S T Lim, J A Kinsella, D Murphy, H M Enright, Dominick J H McCabe
BACKGROUND: The pathophysiological mechanisms responsible for the disparity in stroke risk between asymptomatic and symptomatic carotid stenosis patients are not fully understood. The functionally important reticulated platelet fraction and reticulocytes could play a role. OBJECTIVES: We performed a prospective, multi-centre, observational analytical study comparing full blood count parameters and platelet production/turnover/activation markers in patients with asymptomatic versus recently symptomatic moderate (≥ 50-69%) or severe (≥ 70-99%) carotid stenosis...
May 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29459897/toward-the-relevance-of-platelet-subpopulations-for-transfusion-medicine
#4
REVIEW
Stefan Handtke, Leif Steil, Andreas Greinacher, Thomas Thiele
Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet production in vivo . Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29443372/impact-of-reticulated-platelets-on-the-antiplatelet-effect-of-the-intravenous-p2y12-receptor-inhibitor-cangrelor
#5
Christian Stratz, Thomas Nührenberg, Christian M Valina, Nikolaus Löffelhardt, Kambis Mashayekhi, Miroslaw Ferenc, Dietmar Trenk, Franz-Josef Neumann, Willibald Hochholzer
BACKGROUND:  Reticulated platelets are associated with impaired antiplatelet response to irreversibly acting P2Y12 -receptor inhibitors. However, the impact of reticluated platelets (RP) on the reversibly acting injectable P2Y12 -receptor inhibitor cangrelor is unknown. Thus, this study sought to investigate the influence of RP on cangrelor and transitioning strategies to oral P2Y12 -receptor inhibitors. METHODS:  This study randomized 110 patients undergoing elective percutaneous coronary intervention with use of cangrelor to different oral transitioning strategies loading with prasugrel 60 mg or ticagrelor 180 mg at the start of cangrelor ( n  = 45 each) or loading with clopidogrel 600 mg after discontinuation of cangrelor ( n  = 20)...
February 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29384919/clinical-significance-of-measuring-reticulated-platelets-in-infectious-diseases
#6
Qin-Hua Liu, Ming-Yue Song, Bai-Xia Yang, Rui-Xiang Xia
This study aimed to explore the association between the percentage of reticulated platelets (RP%) and infection, and analyze the value of combined measurement of RP% with other inflammatory indicators in diagnosing infection. A total of 190 patients with signs and symptoms suspicious of infection were included in the infection group, and 70 healthy subjects with comparable percentages of gender and age were included in the control group. Peripheral white blood cell (WBC) count, percentage of neutrophils (N%), platelet count, C-reactive protein (CRP), procalcitonin (PCT), RP%, and axillary temperature were recorded...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377394/platelet-predominate-gene-expression-and-reticulated-platelets-in-nonvalvular-atrial-fibrillation-effect-of-pulmonary-veins-isolation
#7
Waldemar E Wysokinski, Alfonso Tafur, Yanhong Wu, Naser Ammash, Samuel J Asirvatham, Izabela Gosk-Bierska, Diane E Grill, Joshua P Slusser, Jozef Mruk, Robert D McBane
INTRODUCTION: Reticulated platelet (RP) content is increased in nonvalvular atrial fibrillation (NVAF). The purpose of this study was to determine if platelet content, morphology, and RP proportion are modulated by platelet genes. METHODS AND RESULTS: Expression of six platelet-predominate genes impacting platelet formation and release, platelet count, and RP content was assessed in NVAF patients before and 3-4 months after pulmonary veins isolation (PVI) and compared to normal sinus rhythm (NSR) controls...
March 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29240268/assessment-of-procoagulant-potential-in-patients-with-reactive-thrombocytosis-and-its-association-with-platelet-count
#8
Amihai Rottenstreich, Ela Shai, Geffen Kleinstern, Galia Spectre, David Varon, Yosef Kalish
OBJECTIVE: We aimed to determine hemostatic changes and characterize the procoagulant potential among patients with reactive thrombocytosis (RT). METHODS: Sixty patients with RT (median platelet count 718 × 109 /L) and 20 healthy persons were tested for complete blood count, C-reactive protein, von Willebrand factor (VWF), factor VIII and fibrinogen, and thrombin generation. Platelet studies, including light transmission aggregometry and Cone and Plate(let) Analyzer, were also conducted...
March 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29153694/evaluation-of-bone-marrow-function-with-immature-platelet-fraction-in-normal-pregnancy
#9
Ulrike Ratsch, Thorsten Kaiser, Holger Stepan, Alexander Jank
BACKGROUND: Bone marrow function in pregnancy is influencing blood cell concentration of platelets. The steady state of consumption, recovery and production of platelets is essential for coagulation and bleeding prevention. Reticulated platelets are an intermediate form of thrombocytes during thrombopoiesis representing platelet production. The immature platelet fraction (IPF) represents these platelets as percentage of all thrombocytes. Until now, there is little knowledge on IPF during pregnancy...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29149707/over-expression-of-cyclooxygenase-2-in-increased-reticulated-platelets-leads-to-aspirin-resistance-after-elective-off-pump-coronary-artery-bypass-surgery
#10
Xiaoxuan Gong, Xuezhong Wang, Zhuowen Xu, Tiantian Zhu, Qiu Zhang, Jinying Zhang, Xiaowei Wang, Chunjian Li
INTRODUCTION: Aspirin resistance (AR) has been reported to present after coronary artery bypass graft causing saphenous vein graft failure. We aimed to investigate the factors that affect the anti-platelet effect of aspirin after off-pump coronary artery bypass surgery (OPCAB). MATERIALS AND METHODS: Thirty OPCAB candidates were successively recruited. Platelet count, platelet aggregation, reticulated platelet (RP), platelets' cyclooxygenase (COX)-1 and COX-2 expressions were determined during the peri-operative period...
December 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29075447/stress-induced-changes-in-color-expression-mediated-by-iridophores-in-a-polymorphic-lizard
#11
Anna C Lewis, Katrina J Rankin, Andrew J Pask, Devi Stuart-Fox
Stress is an important potential factor mediating a broad range of cellular pathways, including those involved in condition-dependent (i.e., honest) color signal expression. However, the cellular mechanisms underlying the relationship between stress and color expression are largely unknown. We artificially elevated circulating corticosterone levels in male tawny dragon lizards, Ctenophorus decresii , to assess the effect of stress on the throat color signal. Corticosterone treatment increased luminance (paler throat coloration) and decreased the proportion of gray, thereby influencing the gray reticulations that produce unique patterning...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29050503/reticulated-platelets-in-poorly-controlled-diabetes-a-new-era-in-the-management-of-residual-risk
#12
Peter J Grant
No abstract text is available yet for this article.
November 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28939876/thrombopoietic-stimulating-activity-of-rhtyrrs-y341a
#13
Yu Jinchao, Zhang Yanling, Wang Xu, Zhao Bing, Ye Yuhao, Zhou Weiran, Sun Shaoyang, Ma Liyun, Shi Yun, Zhan Ling, Yu Min, Mo Wei
Tumor radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts. Thrombocytopenia is a common disease. Some studies have shown that tRNA synthetase plays not only catalytic tRNA aminoacylation roles, but also functions similarly to cytokines. Recombinant human tyrosyl-tRNA synthetase with a mutated Y341A (rhTyrRS (Y341A)) promotes megakaryocyte migrate from bone marrow to peripheral blood. It would promote megakaryocytes in the lungs adhering to vascular endothelial cells and resulting in the platelet production...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28932736/mean-platelet-volume-and-immature-platelet-fraction-in-autoimmune-disorders
#14
REVIEW
Deonilson Schmoeller, Maria Mercedes Picarelli, Terezinha Paz Munhoz, Carlos Eduardo Poli de Figueiredo, Henrique Luiz Staub
Mean platelet volume (MPV), measured using automated blood analysers, has been appraised as a potential biomarker in cardiovascular disease, diabetes mellitus, and cancer. The test, a useful tool in differentiation of thrombocytopenic states, has now been carried out for autoimmune disorders, but data are yet scarce. Controversial results have been obtained in systemic and organ-specific autoimmune disorders. Another test, the immature platelet fraction (IPF) reflects the amount of young, reticulated platelets...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28880458/determinants-of-platelet-count-in-pediatric-patients-with-congenital-cyanotic-heart-disease-role-of-immature-platelet-fraction
#15
Randa M Matter, Iman A Ragab, Alaa M Roushdy, Ahmed G Ahmed, Hanan H Aly, Eman A Ismail
OBJECTIVES: Congenital heart defects are common noninfectious causes of mortality in children. Bleeding and thrombosis are both limiting factors in the management of such patients. We assessed the frequency of thrombocytopenia in pediatric patients with congenital cyanotic heart disease (CCHD) and evaluated determinants of platelet count including immature platelet fraction (IPF) and their role in the pathogenesis of thrombocytopenia. METHODS: Forty-six children and adolescents with CCHD during pre-catheter visits were studied; median age was 20...
January 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/28821815/epac1-deficient-mice-have-bleeding-phenotype-and-thrombocytes-with-decreased-gpib%C3%AE-expression
#16
Gyrid Nygaard, Lars Herfindal, Kathrine S Asrud, Ronja Bjørnstad, Reidun K Kopperud, Eystein Oveland, Frode S Berven, Lene Myhren, Erling A Hoivik, Turid Helen Felli Lunde, Marit Bakke, Stein O Døskeland, Frode Selheim
Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1(-/-) mice, but not Epac2(-/-) mice, have prolonged bleeding time, suggesting that Epac1 may limit fluid loss also by restraining bleeding. The Epac1(-/-) mice had deficient in vitro secondary hemostasis. Quantitative comprehensive proteomics analysis revealed that Epac1(-/-) mouse platelets (thrombocytes) had unbalanced expression of key components of the glycoprotein Ib-IX-V (GPIb-IX-V) complex, with decrease of GP1bβ and no change of GP1bα...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28648625/anti-erythrocyte-igg-in-hamsters-with-acute-experimental-infection-by-leptospira-interrogans-serovar-canicola
#17
Ânderson O Sobroza, Micheli M Pillat, Guilherme L Dorneles, Márcia S N Machado, Cássia B Silva, Letícia Petry, Andressa Schafer, Raqueli T França, Cinthia M de Andrade, Alfredo Q Antoniazzi, Alexandre A Tonin, Sonia T A Lopes
The aim of this study was to evaluate the behavior of erythrocyte and platelet, as immunological markers, as well as evaluate the involvement of these factors in hemolytic and hemorrhagic reactions in hamsters experimentally infected by Leptospira interrogans Serovar Canicola. Our experimental design was composed by two randomized groups: Infected Group (IG) (n = 12) and control group (CG) (n = 6). Ninety-six hours after the inoculation, the presence of immunoglobulins (IgG and IgM) and complement C3 levels, related to erythrocytes and platelets, was assessed...
June 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28639693/thromboelastography-may-predict-risk-of-grade-2-bleeding-in-thrombocytopenic-patients
#18
E N Opheim, T O Apelseth, S J Stanworth, G E Eide, T Hervig
BACKGROUND AND OBJECTIVES: Platelet count is used as a prophylactic platelet transfusion trigger, although evidence suggests that it is a poor predictor of bleeding. Thus, alternative tests are required. The primary objective of this study was to compare thromboelastography (TEG) parameters on days with and without bleeding symptoms. The secondary objectives were to investigate the relationship between TEG parameters and haematological variables, fever, C-reactive protein (CRP) and platelet transfusion...
August 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28615358/it-s-reticulated-diabetes-atherosclerosis-and-reticulated-platelets
#19
Kathryn Dupnik
New research describes regulatory pathways for reticulated thrombocytosis in a mouse model of diabetes.
June 14, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28504654/sugar-makes-neutrophils-rage-linking-diabetes-associated-hyperglycemia-to-thrombocytosis-and-platelet-reactivity
#20
Robert H Lee, Wolfgang Bergmeier
Diabetes mellitus is associated with an increased risk for cardiovascular disease, but the link between hyperglycemia and atherothrombotic disease is not completely understood. Patients with diabetes often show hyporesponsiveness to antiplatelet therapies, and it has been suggested that hyperreactive reticulated platelets underlie this altered therapeutic response. In this issue of the JCI, Kraakman et al. uncover a previously unknown link between hyperglycemia and enhanced platelet production and reactivity...
June 1, 2017: Journal of Clinical Investigation
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