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https://www.readbyqxmd.com/read/29680437/treatment-of-restless-legs-syndrome-willis-ekbom-disease-with-the-non-selective-ent1-ent2-inhibitor-dipyridamole-testing-the-adenosine-hypothesis
#1
Diego Garcia-Borreguero, Xavier Guitart, Celia Garcia Malo, Irene Cano-Pumarega, Juan José Granizo, Sergi Ferré
OBJECTIVES: Recent animal models of restless legs syndrome (RLS) suggest that brain iron deficiency is associated with a hypoadenosinergic state, with downregulation of adenosine A1 receptors (A1R) in the striatum and cortex. We hypothesized that an increase in extracellular adenosine induced by inhibitors of adenosine transporters, such as the non-selective ENT1/ENT2 inhibitor dipyridamole, would result in an improvement in RLS symptoms. METHODS: In a prospective two-month open-label, non-placebo controlled clinical trial, 15 untreated idiopathic RLS patients began treatment with 100 mg dipyridamole (with uptitration to 400 mg if necessary)...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29678888/bovine-spastic-syndrome-a-review
#2
REVIEW
Victoria Goeckmann, Sophie Rothammer, Ivica Medugorac
Bovine spastic syndrome (BSS) was described for the first time in 1941. The disease occurs in various-maybe even all-cattle breeds and is a chronic-progressive neuromuscular disorder that commonly affects cattle of at least three years of age. Typical clinical signs of the disease are clonic-tonic cramps of the hindlimbs that occur in attacks. Since BSS does not recover, affected animals can only be treated symptomatically by improving welfare conditions and management factors, or with physical therapy or drugs...
April 20, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29673434/diphyllobothriasis-in-a-u-s-military-aviator
#3
Stephen D Kasteler
BACKGROUND: Diphyllobothriasis is estimated to afflict 10-20 million people worldwide; however, this is the first case reported in a United States military aviator. Among the largest parasites of humans, the "fish tapeworm" grows from 2-15 m in length, can live >20 yr in the intestines, and is contracted through consumption of uncooked, unfrozen freshwater or anadromous fish species. CASE REPORT: A 32-yr-old male F-22 pilot presented with mild stomach cramping, bloating, nausea, and intermittent loose stools...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29670513/altered-brain-excitability-and-increased-anxiety-in-mice-with-experimental-colitis-consideration-of-hyperalgesia-and-sex-differences
#4
Kewir D Nyuyki, Nina L Cluny, Mark G Swain, Keith A Sharkey, Quentin J Pittman
Crohn's disease (CD) and ulcerative colitis (UC) are incurable lifelong inflammatory bowel diseases (IBD) with a rising worldwide incidence. IBD is characterized by diarrhea, rectal bleeding, severe cramping and weight loss. However, there is a growing evidence that IBD is also associated with anxiety- and depression-related disorders, which further increase the societal burden of these diseases. Given the limited knowledge of central nervous system (CNS) changes in IBD, we investigated CNS-related comorbidities in a mouse model of experimental colitis induced by dextran sulfate sodium (DSS) administration in drinking water for 5 days...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29670481/exercise-associated-muscle-cramp-doubts-about-the-cause
#5
Dzenan Jahic, Edin Begic
Introduction: Exercise-associated muscle cramp (EAMC) is one of the most common conditions that occur during or immediately after the exercise, with questionable etiology. Aim: Aim of article was to present doubts about the cause of EAMC, whether it is primarily a neurological condition or it is water and salt imbalance. Results: Strongest evidence supports the neuromuscular aetiology with the focus on the muscle fatigue. Muscle overload and fatigue affects the balance between the excitatory drive from muscle spindles and the inhibitory drive from the Golgi tendon organs (GTO)...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29670076/cathelicidins-prime-platelets-to-mediate-arterial-thrombosis-and-tissue-inflammation
#6
Joachim Pircher, Thomas Czermak, Andreas Ehrlich, Clemens Eberle, Erik Gaitzsch, Andreas Margraf, Jochen Grommes, Prakash Saha, Anna Titova, Hellen Ishikawa-Ankerhold, Konstantin Stark, Tobias Petzold, Thomas Stocker, Ludwig T Weckbach, Julia Novotny, Markus Sperandio, Bernhard Nieswandt, Alberto Smith, Hanna Mannell, Barbara Walzog, David Horst, Oliver Soehnlein, Steffen Massberg, Christian Schulz
Leukocyte-released antimicrobial peptides contribute to pathogen elimination and activation of the immune system. Their role in thrombosis is incompletely understood. Here we show that the cathelicidin LL-37 is abundant in thrombi from patients with acute myocardial infarction. Its mouse homologue, CRAMP, is present in mouse arterial thrombi following vascular injury, and derives mainly from circulating neutrophils. Absence of hematopoietic CRAMP in bone marrow chimeric mice reduces platelet recruitment and thrombus formation...
April 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29666885/referred-cramping-phantom-hand-pain-elicited-in-the-face-and-eliminated-by-peripheral-nerve-block
#7
Caroline Dietrich, Sandra Nehrdich, Annette Zimmer, Alexander Ritter, Gunther O Hofmann, Wolfgang H R Miltner, Thomas Weiss
Phantom limb pain is a restricting condition for a substantial number of amputees with quite different characteristics of pain. Here, we report on a forearm amputee with constant phantom pain in the hand, in whom we could regularly elicit the rare phenomenon of referred cramping phantom pain by touching the face. To clarify the underlying mechanisms, we followed the cramp during the course of an axillary blockade of the brachial plexus. During the blockade, both phantom pain and the referred cramp were abolished, while a referred sensation of "being touched at the phantom" persisted...
April 17, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29660929/ecchymosis-a-novel-sign-in-patients-with-varicose-veins
#8
Ertan Yetkin, Mehmet Ileri, Johannes Waltenberger
BACKGROUND: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein. MATERIALS AND METHODS: Four hundred and ninety four patients who had been diagnosed as having varicose vein or chronic venous insufficiency either by clinical examination or Doppler ultrasonography were included in the study...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29602849/a-cross-sectional-survey-of-physical-strains-among-offshore-wind-farm-workers-in-the-german-exclusive-economic-zone
#9
Marcial Velasco Garrido, Janika Mette, Stefanie Mache, Volker Harth, Alexandra M Preisser
OBJECTIVES: To assess the physical strains of employees in the German offshore wind industry, according to job type and phase of the wind farm (under construction or operation). DESIGN: Web-based cross-sectional survey. SETTING: Offshore wind farm companies operating within the German exclusive economic zone. PARTICIPANTS: Male workers with regular offshore commitments and at least 28 days spent offshore in the past year (n=268)...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29596010/whole-body-vibration-on-people-with-sequelae-of-polio
#10
Carolyn P Da Silva, C Lauren Szot, Natasha deSa
PURPOSE: The purpose was to explore the feasibility of whole body vibration (WBV) on polio survivors with/without post-polio syndrome (PPS) by studying its effects on walking speed (10-m walk test), endurance (2-min walk test), pain severity/interference (Brief Pain Inventory [BPI]), sleep quality (Pittsburg Sleep Quality Index), fatigue (Fatigue Severity Scale), leg strength (manual muscle testing and hand-held dynamometry), and muscle cramping (written logs). METHODS: Fifteen individuals completed the study, participating in eight sessions in two 4-week blocks...
March 29, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29590409/motor-unit-number-estimate-and-isometric-hand-grip-strength-in-military-veterans-with-or-without-muscular-complaints-reference-values-for-longitudinal-follow-up
#11
Mian Li, Wenguo Yao, Cynthia Sundahl
Introduction: It remains unclear if Gulf War (GW) veterans have a higher risk of developing motor neuron disorder. We intended to establish baseline neurophysiological values, including thenar motor unit number estimate (MUNE) and isometric hand grip (IHG) strength, to compare future follow-ups of deployed GW veterans with or without muscular complaints. Materials and Methods: We evaluated 19 GW veterans with self-reported weakness, cramps, or excessive muscle fatigue (Ill-19) and compared them with 18 controls without such muscular complaints (C-18)...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29590182/clinical-endpoints-in-the-controlled-human-challenge-model-for-shigella-a-call-for-standardization-and-the-development-of-a-disease-severity-score
#12
Chad K Porter, Amanda Lynen, Mark S Riddle, Kawsar Talaat, David Sack, Ramiro L Gutiérrez, Robin McKenzie, Barbara DeNearing, Brittany Feijoo, Robert W Kaminski, David N Taylor, Beth D Kirkpatrick, A Louis Bourgeois
BACKGROUND: Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and immunologic responses to infection and as a tool for vaccine development. As the frequency and intent for use in vaccine comparisons increases, standardization of the primary endpoint definition is necessary. METHODS: Subject-level data were obtained from previously conducted experimental Shigella CHIM studies...
2018: PloS One
https://www.readbyqxmd.com/read/29589607/a-catastrophic-consequence-of-cramp
#13
Zay Myo Htet, Mahzuz Karim
Quinine has long been used for the treatment of conditions such as malaria and leg cramps, and is also present at low levels in some beverages; however, it can cause serious side effects. We describe a patient who developed severe haemolysis, thrombocytopaenia, and acute kidney injury following the ingestion of a single dose of quinine. This case demonstrates the importance of awareness of such potentially life-threatening consequences of exposure to this agent.
2018: Acute Medicine
https://www.readbyqxmd.com/read/29582541/relationship-of-muscle-cramps-to-quality-of-life-and-sleep-disturbance-in-patients-with-chronic-liver-diseases-a-nationwide-study
#14
Motoh Iwasa, Yoshiyasu Karino, Takumi Kawaguchi, Hiroyuki Nakanishi, Hisamitsu Miyaaki, Makoto Shiraki, Tomoaki Nakajima, Yasuhiko Sawada, Hitoshi Yoshiji, Kiwamu Okita, Kazuhiko Koike
BACKGROUND & AIMS: Although muscle cramps frequently occur in patients with cirrhosis, the importance of muscle cramps remains unclear. The aims of this study were to investigate the relationship of muscle cramps with quality of life (QOL) and sleep disturbance. In addition, this multi-institutional collaborative study in Japan investigated factors associated with muscle cramps in patients with cirrhosis. METHODS: A total of 1,788 patients with chronic liver diseases including both non-cirrhosis and cirrhosis completed a questionnaire survey investigating: i) frequency of muscle cramps, ii) relationship of muscle cramps to poor QOL and sleep disturbance, iii) characteristics of patients who require therapeutic intervention, and iv) characteristics of patients prone to experiencing muscle cramps...
March 27, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29581918/steroids-and-thyrotoxicosis-precipitate-periodic-paralysis
#15
Rizwan Ahamed, Sarah McCalley, Anupam A Sule
Thyrotoxic Periodic Paralysis (TPP) belongs to a group of muscle diseases called channelopathies, which present with painless generalized muscle weakness without exertion. TPP can be precipitated by a large carbohydrate meal, stress, strenuous exercise, alcohol, a high-salt diet, menstruation, and cold temperatures. Rarely, steroids such as dexamethasone can also precipitate a TPP attack. A 29-year-old Hispanic male, with a history of hyperthyroidism, presented to the emergency department with progressive weakness, predominantly in the lower extremities since morning...
January 23, 2018: Curēus
https://www.readbyqxmd.com/read/29577553/metformin-s-impact-on-statin-associated-muscle-symptoms-an-analysis-of-accord-study-data-and-research-materials-from-the-nhlbi-biologic-specimen-and-data-repository-information-coordinating-center
#16
Nicholas W Carris, Athanasios Tsalatsanis, Srinivas M Tipparaju, Feng Cheng, Ronald R Magness, Ambuj Kumar
Statins are widely prescribed, yet statin muscle pain limits use, leading to increased cardiovascular risk. No validated therapy for statin muscle pain exists. The goal of the study was to assess if metformin was associated with reduced muscle pain. A secondary analysis of data from the ACCORD trial was performed. An ACCORD sub-study assessed patients for muscle cramps and leg/calve pain while walking, typical non-severe statin muscle pain symptoms. We compared muscle pain between patients taking a statin (n = 445) or a statin and metformin (n = 869) at baseline...
March 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29576359/correlation-of-symptoms-to-serum-vitamin-d-levels
#17
Mir Sadat-Ali, Omar N Al Essa, Fawaz M Alani, Hussain K Al Omar, Walid Y Ebrahim
BACKGROUND AND OBJECTIVE: Recent studies have shown that vitamin D plays an important role in many disease processes. However, data is lacking which correlates the common symptoms attributed with vitamin D levels. This study was undertaken to find the correlation of symptoms and Vitamin D levels among ethnic Saudi Arabian population. METHODS: A structured questionnaire was made and translated in the Arabic language, which included, age, weight and height, ethnicity and marital status...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29572370/two-cases-of-hypokalaemic-rhabdomyolysis-same-but-different
#18
Philipp Pecnik, Petra Müller, Sybille Vrabel, Martin Windpessl
In this paper, we present two women with hypokalaemic rhabdomyolysis in the context of increased diuretic intake and gastroenteritis, respectively. While their clinical manifestations and laboratory results were strikingly similar, two different underlying disorders were subsequently unveiled. The first patient was diagnosed with Conn syndrome, and adrenalectomy led to significant improvement of hypertension and sustained normokalaemia. The diagnosis in the second patient was Gitelman syndrome. Electrolyte supplements improved long-term lassitude and the frequency of muscle cramps declined significantly...
March 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29560763/pre-and-peripartal-management-of-a-woman-with-mcardle-disease-a-case-report
#19
Tina Stopp, Michael Feichtinger, Wolfgang Eppel, Thomas M Stulnig, Peter Husslein, Christian Göbl
McArdle disease or glycogen storage disease (GSD) type V is a rare autosomal recessive inherited disorder in skeletal muscle metabolism leading to exercise intolerance, muscle cramps and in some cases to rhabdomyolysis and acute renal failure due to elevated serum myoglobin levels. Albeit the uterine smooth muscle is not affected, pregnancy and delivery can be physically strenuous and may require specific anesthesiologic care. However, data on pregnancy progress and outcome and on special implications linked to anesthesia in women with McArdle's disease is scarce, thus posing a challenge to pre- and peripartal management...
March 21, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29559676/obesity-induced-endothelial-dysfunction-is-prevented-by-neutrophil-extracellular-trap-inhibition
#20
Hui Wang, Qian Wang, Jessica Venugopal, Jintao Wang, Kyle Kleiman, Chiao Guo, Daniel T Eitzman
Endothelial dysfunction precedes atherosclerosis and may constitute a critical link between obesity-related inflammation and cardiovascular disease. Neutrophil extracellular traps (NETs) have been shown to promote vascular damage in murine models of autoimmune disease and atherosclerosis. The impact of NETs towards endothelial dysfunction associated with obesity is unknown. Using a diet-induced obesity (DIO) mouse model, this study investigated whether the inhibition or degradation of NETs could reduce the endothelial dysfunction observed in DIO mice...
March 20, 2018: Scientific Reports
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