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https://www.readbyqxmd.com/read/27917824/on-the-interpretation-of-reflectivity-data-from-lipid-bilayers-in-terms-of-molecular-dynamics-models
#1
Arwel V Hughes, Fillip Ciesielski, Antreas C Kalli, Luke A Clifton, Timothy R Charlton, Mark S P Sansom, John R P Webster
Neutron and X-ray reflectivity of model membranes is increasingly used as a tool for the study of membrane structures and dynamics. As the systems under study become more complex, and as long, all-atom molecular-dynamics (MD) simulations of membranes become more available, there is increasing interest in the use of MD simulations in the analysis of reflectometry data from membranes. In order to perform this, it is necessary to produce a model of the complete interface, including not only the MD-derived structure of the membrane, but also the supporting substrate and any other interfacial layers that may be present...
December 1, 2016: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/27913731/disentangling-polydispersity-in-the-pcna-p15paf-complex-a-disordered-transient-and-multivalent-macromolecular-assembly
#2
Tiago N Cordeiro, Po-Chia Chen, Alfredo De Biasio, Nathalie Sibille, Francisco J Blanco, Jochen S Hub, Ramon Crehuet, Pau Bernadó
The intrinsically disordered p15(PAF) regulates DNA replication and repair when interacting with the Proliferating Cell Nuclear Antigen (PCNA) sliding clamp. As many interactions between disordered proteins and globular partners involved in signaling and regulation, the complex between p15(PAF) and trimeric PCNA is of low affinity, forming a transient complex that is difficult to characterize at a structural level due to its inherent polydispersity. We have determined the structure, conformational fluctuations, and relative population of the five species that coexist in solution by combining small-angle X-ray scattering (SAXS) with molecular modelling...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27904549/effects-of-nigella-sativa-supplementation-on-blood-parameters-and-anthropometric-indices-in-adults-a-systematic-review-on-clinical-trials
#3
REVIEW
Alireza Mohtashami, Mohammad Hasan Entezari
BACKGROUND: Nigella sativa (N. sativa) has been used in traditional medicine and several studies have been performed in the last decades to reveal the effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension, and obesity. We evaluated the effects of N. sativa supplementation on lipid profiles, glycemic control, blood pressure (BP), and some anthropometric indices in humans. MATERIALS AND METHODS: A search on published studies was done by using databases including PubMed, Google Scholar, Thomas Reuters Web of Science, and Cochrane...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27902848/topiramate-in-migraine-prevention-a-2016-perspective
#4
Stephen D Silberstein
BACKGROUND: In evidence-based guidelines published in 2000, topiramate was a third-tier migraine preventive with no scientific evidence of efficacy; recommendation for its use reflected consensus opinion and clinical experience. Its neurostabilizing activity, coupled with its favorable weight profile, made topiramate an attractive alternative to other migraine preventives that caused weight gain. When guidelines for migraine prevention in episodic migraine were published in 2012, topiramate was included as a first-line option based on double-blind, randomized controlled trials involving nearly 3000 patients...
November 30, 2016: Headache
https://www.readbyqxmd.com/read/27902748/features-of-the-asynchronous-correlation-between-the-china-coal-price-index-and-coal-mining-accidental-deaths
#5
Yuecheng Huang, Wuyi Cheng, Sida Luo, Yun Luo, Chengchen Ma, Tailin He
The features of the asynchronous correlation between accident indices and the factors that influence accidents can provide an effective reference for warnings of coal mining accidents. However, what are the features of this correlation? To answer this question, data from the China coal price index and the number of deaths from coal mining accidents were selected as the sample data. The fluctuation modes of the asynchronous correlation between the two data sets were defined according to the asynchronous correlation coefficients, symbolization, and sliding windows...
2016: PloS One
https://www.readbyqxmd.com/read/27902452/high-ambient-noise-levels-in-vadodara-city-india-affected-by-urbanization
#6
Neha Singh, Hitesh Dhiman, Sadaf Shaikh, Purvish Shah, Roma Sarkar, Shashin Patel
The present research was conducted to study the urbanization of Vadodara city and to monitor the ambient noise level in the industrial, commercial, residential and silence zones of the city. A settlement map created by unsupervised classification for the land use and land cover study of Vadodara city clearly shows the increasing pattern of urbanization in its central part, which may be the result of urban sprawl due to migration of people from the rural to the urban areas. The fluctuation in ambient noise level was recorded using an A-weighted sound level meter in all the four zones of Vadodara city for 3 h at regular intervals of 15 min on 3 consecutive days at the same time...
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27898859/regional-and-seasonal-analyses-of-weights-in-growing-angus-cattle
#7
H L Bradford, B O Fragomeni, J K Bertrand, D A L Lourenco, I Misztal
This study evaluated the impact of region and season on growth in Angus seed stock. To assess geographic differences, the United States was partitioned into 9 regions based on similar climate and topography related to cow-calf production. Seasonal effects were associated with the month that animals were weighed. The American Angus Association provided growth data, and records were assigned to regions based on the owner's zip code. Most Angus cattle were in the Cornbelt, Lower Plains, Rocky Mountain, Upper Plains, and Upper South regions, with proportionally fewer Angus in Texas compared with the national cow herd...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897121/role-of-melatonin-in-body-weight-a-systematic-review-and-meta-analysis
#8
Seyed-Ali Mostafavi, Shahin Akhondzadeh, Mohammad Reza Mohammadi, Abbas-Ali Keshtkar, Saeed Hosseini, Mohammad Reza Eshraghian, Fahimeh Ahmadi, Roya Alipour, Seyed Ali Keshavarz
BACKGROUND: Some trials on animals and human claim that melatonin can influence body weight. So we conducted a systematic review of controlled trials of melatonin effects on weight of human subjects. METHODS: First we performed a systematic and comprehensive search in June 2015 on MEDLINE/PubMed, Scopus, Google scholar, hand searching in key journals, the list of references of selected articles and gray literature. RESULTS: We included 7 clinical trials with a total of 244 patients...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27889876/population-pharmacokinetic-pharmacodynamic-modeling-of-5-fluorouracil-for-toxicities-in-rats
#9
Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
BACKGROUND AND OBJECTIVES: Myelosuppression is a dose-limiting toxicity of 5-fluorouracil (5-FU). Predicting the inter- and intra-patient variability in pharmacokinetics and toxicities of 5-FU may contribute to the individualized medicine. This study aimed to establish a population pharmacokinetic-pharmacodynamic model that could evaluate the inter- and intra-individual variability in the plasma 5-FU concentration, 5-FU-induced body weight loss and myelosuppression in rats. METHOD: Plasma 5-FU concentrations, body weight loss, and blood cell counts in rats following the intravenous administration of various doses of 5-FU for 4 days were used to develop the population pharmacokinetic-pharmacodynamic model...
November 26, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27875485/a-comparative-study-of-the-water-drinking-test-in-eyes-with-open-angle-glaucoma-and-prior-trabeculectomy-or-tube-shunt
#10
Patricia Martinez, Valerie Trubnik, Benjamin E Leiby, Sarah E Hegarty, Reza Razeghinejad, Shravan Savant, Jonathan S Myers
PURPOSE: To compare the intraocular pressure (IOP) response after the water drinking test (WDT) in patients who have undergone trabeculectomy or tube shunt surgery. METHODS: This prospective study examined 40 eyes of 34 open-angle glaucoma subjects who had undergone trabeculectomy (n=20) or tube shunt surgery (n=20). Both groups were matched by IOP range and by number of topical antiglaucoma medications used. After a baseline IOP assessment, subjects drank 10 mL water per kg body weight over 15 minutes...
November 21, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27869935/method-for-estimating-infant-mortality-and-low-birth-weight-indicators-for-brazilian-municipalities-2012
#11
Alicia Matijasevich, Juan José Cortez-Escalante, Dacio Rabello, Roberto Men Fernandes, Cesar Gomes Victora
OBJECTIVE: to present a method for estimating low birth weight (LBW) prevalence and infant mortality rate (IMR) indicators for Brazilian municipalities, so as to incorporate considerations with regard to sampling fluctuation. METHODS: binomial and Poisson distributions were used to estimate 95% confidence intervals (95%CI); when the number of infant deaths was zero, the upper limit of the 95%CI was estimated by the cross-multiplication method; indicators were estimated for the year 2012 for demonstration purposes...
July 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27866188/feasibility-of-laryngeal-mask-airway-device-placement-in-neonates
#12
Amanda A Wanous, Andrew Wey, Kyle D Rudser, Kari D Roberts
BACKGROUND: The laryngeal mask airway (LMA) has been used in adult and pediatric populations for decades. While the familiarity of its use in the neonatal population is increasing, there are few data investigating this. OBJECTIVE: The objective of this study was to determine the feasibility of LMA placement in neonates by investigating the time and number of attempts required for successful placement and physiologic stability during the placement of the device. METHODS: This study is one component of a national, multicenter, randomized controlled trial investigating surfactant administration through an LMA in neonates...
November 19, 2016: Neonatology
https://www.readbyqxmd.com/read/27862918/changes-in-body-mass-index-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-without-cranial-radiation-and-with-reduced-glucocorticoid-therapy
#13
Lauren M Touyz, Jennifer Cohen, Kristen A Neville, Claire E Wakefield, Sarah P Garnett, Kylie-Ann Mallitt, Allison M Grech, Richard J Cohn
BACKGROUND: Cranial radiation and glucocorticoids are associated with an increase in body mass index (BMI) z-score in survivors of childhood acute lymphoblastic leukemia (ALL). We aimed to investigate the impact of a contemporary treatment protocol that omitted prophylactic cranial radiation and glucocorticoids from the maintenance phase on longitudinal BMI, height, and weight z-scores in children with ALL. METHOD: We retrospectively studied 184 children with standard- and medium-risk ALL treated without cranial radiation or glucocorticoids...
November 10, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27859614/a-comparison-of-navigators-snap-shot-field-monitoring-and-probe-based-field-model-training-for-correcting-b0-induced-artifacts-in-t2-weighted-images-at-7%C3%A2-t
#14
Joep Wezel, Vincent O Boer, Tijl A van der Velden, Andrew G Webb, Dennis W J Klomp, Maarten J Versluis, Matthias J P van Osch, Anders Garpebring
PURPOSE: To compare methods for estimating B0 maps used in retrospective correction of high-resolution anatomical images at ultra-high field strength. The B0 maps were obtained using three methods: (1) 1D navigators and coil sensitivities, (2) field probe (FP) data and a low-order spherical harmonics model, and (3) FP data and a training-based model. METHODS: Data from nine subjects were acquired while they performed activities inducing B0 field fluctuations. Estimated B0 fields were compared with reference data, and the reductions of artifacts were compared in corrected T2* images...
November 17, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27845359/characterizing-the-blood-oxygen-level-dependent-fluctuations-in-musculoskeletal-tumours-using-functional-magnetic-resonance-imaging
#15
Li-Sha Duan, Meng-Jun Wang, Feng Sun, Zhen-Jiang Zhao, Mei Xing, Yu-Feng Zang, Steven Louis, Sheng-Jie Cui, Jian-Ling Cui, Han Zhang
This study characterized the blood oxygen level-dependent (BOLD) fluctuations in benign and malignant musculoskeletal tumours via power spectrum analyses in pre-established low-frequency bands. BOLD MRI and T1-weighted imaging (T1WI) were collected for 52 patients with musculoskeletal tumours. Three ROIs were drawn on the T1WI image in the tumours' central regions, peripheral regions and neighbouring tissue. The power spectrum of the BOLD within each ROI was calculated and divided into the following four frequency bands: 0...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27837284/forest-dynamics-to-precipitation-and-temperature-in-the-gulf-of-mexico-coastal-region
#16
Tianyu Li, Qingmin Meng
The forest is one of the most significant components of the Gulf of Mexico (GOM) coast. It provides livelihood to inhabitant and is known to be sensitive to climatic fluctuations. This study focuses on examining the impacts of temperature and precipitation variations on coastal forest. Two different regression methods, ordinary least squares (OLS) and geographically weighted regression (GWR), were employed to reveal the relationship between meteorological variables and forest dynamics. OLS regression analysis shows that changes in precipitation and temperature, over a span of 12 months, are responsible for 56% of NDVI variation...
November 12, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27816325/lack-of-association-between-depression-and-c-reactive-protein-level-in-the-baseline-of-longitudinal-study-of-adult-health-elsa-brasil
#17
Sara Teles de Menezes, Roberta Carvalho de Figueiredo, Alessandra Carvalho Goulart, Maria Angélica Nunes, Isabela M Benseñor, Maria Carmen Viana, Sandhi Maria Barreto
BACKGROUND: Depression has been linked to increased levels of inflammatory markers in clinical studies, but results from general population samples are inconsistent. We aimed to investigate whether depression was associated with serum CRP levels in a cross-sectional analysis of a large cohort from a middle-income country. METHODS: We analyzed baseline data from 14,821 participants (35-74 years) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Current depression (last 7 days) was assessed by the Clinical Interview Schedule-Revised (CIS-R)...
October 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27815669/effect-of-agro-ecological-zone-season-of-birth-and-sex-on-pre-weaning-performance-of-nguni-calves-in-limpopo-province-south-africa
#18
T J Mpofu, M M Ginindza, N A Siwendu, K A Nephawe, B J Mtileni
The study was conducted to determine the effect of agro-ecological zone, season of birth and sex on Nguni calves' pre-weaning performance. Production indices such as birth weight (BW), weaning weight (WW), pre-weaning average daily gain (P-ADG) and pre-weaning gain (P-WG) were assessed in the different agro-ecological zones. Herd records on performance of 826 Nguni calves' from nine Nguni herds representing different agro-ecological zones: arid zone (n = 217); semi-arid zone (n = 296); dry sub-humid zone (n = 118) and humid zone (n = 195) were used for the analysis of pre-weaning calf performance...
November 4, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27812185/phenology-and-seed-yield-performance-of-determinate-soybean-cultivars-grown-at-elevated-temperatures-in-a-temperate-region
#19
Doug-Hwan Choi, Ho-Young Ban, Beom-Seok Seo, Kyu-Jong Lee, Byun-Woo Lee
Increased temperature means and fluctuations associated with climate change are predicted to exert profound effects on the seed yield of soybean. We conducted an experiment to evaluate the impacts of global warming on the phenology and yield of two determinate soybean cultivars in a temperate region (37.27°N, 126.99°E; Suwon, South Korea). These two soybean cultivars, Sinpaldalkong [maturity group (MG) IV] and Daewonkong (MG VI), were cultured on various sowing dates within a four-year period, under no water-stress conditions...
2016: PloS One
https://www.readbyqxmd.com/read/27809971/vaccination-of-goats-against-haemonchus-contortus-with-the-gut-membrane-proteins-h11-h-gal-gp
#20
Lorena Meier, Paul R Torgerson, Hubertus Hertzberg
Forty goats, aged from 2 to 5 months were subjected to two different immunization protocols with a vaccine containing Haemonchus contortus gut membrane proteins H11/H-gal-GP to evaluate protection against H. contortus on pre-contaminated pastures. Goats were allocated to four groups of ten, three of them received their first vaccination before turnout. One group (V4) was then vaccinated at 4-week-intervals whereas another two groups (V6 and V6SEP) were vaccinated at 6-week-intervals. A control group (CTRL) remained unvaccinated...
October 15, 2016: Veterinary Parasitology
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