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https://www.readbyqxmd.com/read/29448435/shear-stress-fluctuations-and-relaxation-in-polymer-glasses
#1
I Kriuchevskyi, J P Wittmer, H Meyer, O Benzerara, J Baschnagel
We investigate by means of molecular dynamics simulation a coarse-grained polymer glass model focusing on (quasistatic and dynamical) shear-stress fluctuations as a function of temperature T and sampling time Δt. The linear response is characterized using (ensemble-averaged) expectation values of the contributions (time averaged for each shear plane) to the stress-fluctuation relation μ_{sf} for the shear modulus and the shear-stress relaxation modulus G(t). Using 100 independent configurations, we pay attention to the respective standard deviations...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29427608/comparison-between-male-and-female-rats-in-a-model-of-self-administration-of-a-chocolate-flavored-beverage-behavioral-and-neurochemical-studies
#2
Andrea Contini, Fabrizio Sanna, Paola Maccioni, Giancarlo Colombo, Antonio Argiolas
The existence of sex differences was studied in a rat model of operant self-administration of a chocolate-flavored beverage (CFB), which possesses strong reinforcing properties and is avidly consumed by rats. Whether these differences occurred concomitantly to changes in extracellular dopamine in the dialysate obtained from the nucleus accumbens, was assessed by intracerebral microdialysis. Male, ovariectomized and intact female rats showed similar self-administration profiles, with minor differences in both acquisition and maintenance phases...
February 7, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29427063/functional-brain-abnormalities-in-major-depressive-disorder-using-the-hilbert-huang-transform
#3
Haibin Yu, Feng Li, Tong Wu, Rui Li, Li Yao, Chuanyue Wang, Xia Wu
Major depressive disorder is a common disease worldwide, which is characterized by significant and persistent depression. Non-invasive accessory diagnosis of depression can be performed by resting-state functional magnetic resonance imaging (rs-fMRI). However, the fMRI signal may not satisfy linearity and stationarity. The Hilbert-Huang transform (HHT) is an adaptive time-frequency localization analysis method suitable for nonlinear and non-stationary signals. The objective of this study was to apply the HHT to rs-fMRI to find the abnormal brain areas of patients with depression...
February 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29421884/multiscale-weighted-colored-graphs-for-protein-flexibility-and-rigidity-analysis
#4
David Bramer, Guo-Wei Wei
Protein structural fluctuation, measured by Debye-Waller factors or B-factors, is known to correlate to protein flexibility and function. A variety of methods has been developed for protein Debye-Waller factor prediction and related applications to domain separation, docking pose ranking, entropy calculation, hinge detection, stability analysis, etc. Nevertheless, none of the current methodologies are able to deliver an accuracy of 0.7 in terms of the Pearson correlation coefficients averaged over a large set of proteins...
February 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29416078/support-vector-machines-for-explaining-physiological-stress-response-in-wood-mice-apodemus-sylvaticus
#5
Beatriz Sánchez-González, Isabel Barja, Ana Piñeiro, M Carmen Hernández-González, Gema Silván, Juan Carlos Illera, Roberto Latorre
Physiological stress response is a crucial adaptive mechanism for prey species survival. This paper aims to identify the main environmental and/or individual factors better explaining the stress response in Wood mice, Apodemus sylvaticus. We analyzed alterations in fecal glucocorticoid metabolite (FCM) concentration - extensively used as an accurate measure of the physiological stress response - of wild mice fecal samples seasonally collected during three years. Then, support vector machines were built to predict said concentration according to different stressors...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414405/eeg-synchronization-measures-predict-epilepsy-related-bold-fmri-fluctuations-better-than-commonly-used-univariate-metrics
#6
Rodolfo Abreu, Alberto Leal, Fernando Lopes da Silva, Patrícia Figueiredo
OBJECTIVE: We hypothesize that the hypersynchronization associated with epileptic activity is best described by EEG synchronization measures, and propose to use these as predictors of epilepsy-related BOLD fluctuations. METHODS: We computed the phase synchronization index (PSI) and global field synchronization (GFS), within two frequency bands, a broadband (1-45 Hz) and a narrower band focused on the presence of epileptic activity (3-10 Hz). The associated epileptic networks were compared with those obtained using conventional unitary regressors and two power-weighted metrics (total power and root mean square frequency), on nine simultaneous EEG-fMRI datasets from four epilepsy patients, exhibiting inter-ictal epileptiform discharges (IEDs)...
January 11, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29414030/effects-of-blood-glucose-on-delay-discounting-food-intake-and-counterregulation-in-lean-and-obese-men
#7
Johanna Klement, Britta Kubera, Jonas Eggeling, Christin Rädel, Christin Wagner, Soyoung Q Park, Achim Peters
BACKGROUND: Delay discounting as a measure of impulsivity has been shown to be higher in obesity with an association of increased food intake. Moreover, obese humans showed a higher wanting for high-calorie food than lean men when blood glucose concentrations were low. First studies linking blood glucose levels to delay discounting yielded mixed results. We hypothesized that obese people - in comparison to lean men - have a relative lack of energy, especially when blood glucose levels are low, that results in higher levels of delay discounting, food intake and hormonal counterregulation...
January 23, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29413623/self-assembled-nanoformulation-of-methylprednisolone-succinate-with-carboxylated-block-copolymer-for-local-glucocorticoid-therapy
#8
Marat I Kamalov, Trinh Đặng, Natalia V Petrova, Alexander V Laikov, Duong Luong, Rezeda A Akhmadishina, Andrei N Lukashkin, Timur I Abdullin
A new self-assembled formulation of methylprednisolone succinate (MPS) based on a carboxylated trifunctional block copolymer of ethylene oxide and propylene oxide (TBC-COOH) was developed. TBC-COOH and MPS associated spontaneously at increased concentrations in aqueous solutions to form almost monodisperse mixed micelles (TBC-COOH/MPS) with a hydrodynamic diameter of 19.6 nm, zeta potential of -27.8 mV and optimal weight ratio ∼1:6.3. Conditions for the effective formation of TBC-COOH/MPS were elucidated by comparing copolymers and glucocorticoids with different structure...
January 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29408817/prelemniscal-lesion-for-selective-improvement-of-parkinson-disease-tremor
#9
Francisco Velasco, Mauricio Esqueda-Liquidano, Ana Luisa Velasco, Maria Guadalupe García-Gomar
BACKGROUND: Selective improvement of symptoms may be required when treating Parkinson disease (PD) patients with a predominantly monosymptomatic clinical picture. OBJECTIVE: To define a target in prelemniscal radiation fibers (Raprl) related to the physiopathology of tremor evidenced by tractography. CASE REPORT: We report a patient with predominant unilateral rest and postural tremor, diagnosed as PD based on 80% improvement induced by the administration of L-DOPA/carbidopa, subsequently complicated by motor fluctuations, L-DOPA dyskinesia, and a reduced ON period...
February 6, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29408283/crosstalk-free-multicolor-rics-using-statistical-weighting
#10
Waldemar Schrimpf, Veerle Lemmens, Nick Smisdom, Marcel Ameloot, Don C Lamb, Jelle Hendrix
Raster image cross-correlation spectroscopy (ccRICS) can be used to quantify the interaction affinities between diffusing molecules by analyzing the fluctuations between two-color confocal images. Spectral crosstalk compromises the quantitative analysis of ccRICS experiments, limiting multicolor implementations to dyes with well-separated emission spectra. Here, we remove this restriction by introducing raster spectral image correlation spectroscopy (RSICS), which employs statistical filtering based on spectral information to quantitatively separate signals of fluorophores during spatial correlation analysis...
February 2, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29407899/the-relationship-between-external-auditory-canal-temperature-and-onset-of-estrus-and-ovulation-in-beef-heifers
#11
Federico Randi, Michael McDonald, Pat Duffy, Alan K Kelly, Patrick Lonergan
The aim of this study was to evaluate the relationship of body temperature fluctuations, as measured by external auditory canal temperature, to the onset of estrus and ovulation. Beef heifers (n = 44, mean age 23.5 ± 0.4 months, mean weight 603.3 ± 5.7 kg) were fitted with a Boviminder® ear tag 2 weeks before the start of the estrous synchronization protocol to allow acclimatization. The device recorded the temperature, accurate to 0.01° Fahrenheit, every 10 min and transmitted the data via a base station over the internet where it could be accessed remotely...
January 9, 2018: Theriogenology
https://www.readbyqxmd.com/read/29405980/multiscale-nuclear-magnetic-relaxation-dispersion-of-complex-liquids-in-bulk-and-confinement
#12
REVIEW
Jean-Pierre Korb
The nuclear magnetic relaxation dispersion (NMRD) technique consists of measurement of the magnetic-field dependence of the longitudinal nuclear-spin-lattice relaxation rate 1/T1. Usually, the acquisition of the NMRD profiles is made using a fast field cycling (FFC) NMR technique that varies the magnetic field and explores a very large range of Larmor frequencies (10 kHz < ω0/(2π) <40 MHz). This allows extensive explorations of the fluctuations to which nuclear spin relaxation is sensitive...
February 2018: Progress in Nuclear Magnetic Resonance Spectroscopy
https://www.readbyqxmd.com/read/29403155/fluctuation-of-blood-glucose-levels-in-an-infant-with-an-ileostomy-on-continuous-glucose-monitoring-a-case-report
#13
Seiichi Tomotaki, Tetsuo Naramura, Junko Hanakawa, Katsuaki Toyoshima, Koji Muroya, Masanori Adachi
Infants with an ileostomy can be at high risk of hypoglycemia because of inadequate nutritional intake; however, there are no reports investigating blood glucose (BG) in infants with ileostomy. We experienced a case of an extremely low birth weight infant who was born at 24 wk of gestation and weighted 623 g. He received an ileostomy because of an intestinal perforation. After the ileostomy, he had recurrent hypoglycemia. Continuous glucose monitoring showed fluctuation of BG levels (postprandial BG elevations and subsequent declines) and non-fasting hypoglycemia, which were undetectable with intermittent fasting BG measurement...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29402170/residual-limb-fluid-volume-change-and-volume-accommodation-relationships-to-activity-and-self-report-outcomes-in-people-with-trans-tibial-amputation
#14
Joan E Sanders, Robert T Youngblood, Brian J Hafner, Marcia A Ciol, Katheryn J Allyn, David Gardner, John C Cagle, Christian B Redd, Colin R Dietrich
BACKGROUND: Fluctuations in limb volume degrade prosthesis fit and require users to accommodate changes using management strategies, such as donning and doffing prosthetic socks. OBJECTIVES: To examine how activities and self-report outcomes relate to daily changes in residual limb fluid volume and volume accommodation. STUDY DESIGN: Standardized, two-part laboratory protocol with an interim observational period. METHODS: Participants were classified as "accommodators" or "non-accommodators," based on self-report prosthetic sock use...
February 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29385889/enhanced-recovery-after-surgery-program-with-dexamethasone-administration-for-major-head-and-neck-surgery-with-free-tissue-transfer-reconstruction-initial-institutional-experience
#15
Takayuki Imai, Koreyuki Kurosawa, Kayo Yamaguchi, Naoko Satake, Yukinori Asada, Ko Matsumoto, Sinkichi Morita, Satoshi Saijo, Jiro Aoi, Keitaro Fujii, Kazuhiro Kishimoto, Takahiro Goto, Kazuto Matsuura
OBJECTIVES: Enhanced Recovery After Surgery (ERAS) protocols promote recovery after various invasive surgeries. Likewise, preoperative glucocorticoid administration can reduce complications after some surgeries. However, the effects of ERAS protocols and glucocorticoid administration in patients undergoing major surgery for head and neck cancer have not been well described. The aim of this study was to evaluate the effect of an ERAS protocol with preoperative glucocorticoid administration in major surgery for head and neck cancer...
January 31, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29385781/the-external-performance-appraisal-of-china-energy-regulation-an-empirical-study-using-a-topsis-method-based-on-entropy-weight-and-mahalanobis-distance
#16
Zheng-Xin Wang, Dan-Dan Li, Hong-Hao Zheng
In China's industrialization process, the effective regulation of energy and environment can promote the positive externality of energy consumption while reducing negative externality, which is an important means for realizing the sustainable development of an economic society. The study puts forward an improved technique for order preference by similarity to an ideal solution based on entropy weight and Mahalanobis distance (briefly referred as E-M-TOPSIS). The performance of the approach was verified to be satisfactory...
January 30, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29385349/exploration-of-multistate-conformational-dynamics-upon-ligand-binding-of-a-monomeric-enzyme-involved-in-pyrophosphoryl-transfer
#17
Lingci Zhao, H Peter Lu, Jin Wang
HPPK (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) is a monomeric protein with 158 residues, which undergoes large scale conformational changes between apo, open, and holo states responding to ligand binding for its function. It has been explored widely as an excellent target for potential antibacterial drug development. However, little is known about how conformational dynamics between the native states influences the substrate recognition and the functionality of enzymatic catalysis. Here, we report a coarse-grained triple-basin structure-based model upon ligand binding to describe such multiple-state system by the molecular dynamics simulation...
January 31, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29366322/characterizing-sorption-and-permeation-properties-of-membrane-filters-used-for-aquatic-integrative-passive-samplers
#18
Satoshi Endo, Yunosuke Matsuura
Aquatic integrative passive sampling is a promising approach to measure the time-weighted average concentration, yet our understanding for the sampling mechanisms of polar organic contaminants should be further advanced to fully exploit the potential of the method for real-world applications. This study aimed to characterize the sorption and permeation properties of polyethersulfone (PES) and poly(tetrafluoroethylene) (PTFE) membrane filters (MFs) used for passive samplers. Batch sorption experiments with 14 probe chemicals showed that the sorption by PES was generally strong, with the respective sorption coefficients greater than the octanol-water partition coefficients by 2-3 log units...
January 25, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29358677/collective-responses-in-electrical-activities-of-neurons-under-field-coupling
#19
Ying Xu, Ya Jia, Jun Ma, Tasawar Hayat, Ahmed Alsaedi
Synapse coupling can benefit signal exchange between neurons and information encoding for neurons, and the collective behaviors such as synchronization and pattern selection in neuronal network are often discussed under chemical or electric synapse coupling. Electromagnetic induction is considered at molecular level when ion currents flow across the membrane and the ion concentration is fluctuated. Magnetic flux describes the effect of time-varying electromagnetic field, and memristor bridges the membrane potential and magnetic flux according to the dimensionalization requirement...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29355902/maternal-breast-and-body-symmetry-in-pregnancy-and-offspring-condition
#20
Agnieszka Żelaźniewicz, Bogusław Pawłowski
OBJECTIVES: Fluctuating asymmetry (FA) is hypothesized to reflect the level of an individual's developmental instability, and therefore genetic quality. As a potential signal of biological condition, female body (including breast) symmetry was shown to be perceived as more attractive in mate choice context. If symmetry reflects a woman's genetic quality, it is possible that FA, similarly to other maternal anthropometric cues of biological condition (e.g., body height or waist-to-hip ratio), may be also related to her offspring condition...
January 22, 2018: American Journal of Physical Anthropology
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