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https://www.readbyqxmd.com/read/29674261/acclimatization-of-pisum-sativum-l-grown-in-soil-contaminated-with-veterinary-antibiotics-an-attribute-of-dose-hormetic-response-of-root-metabolites
#1
R P Tasho, W T Shin, J Y Cho
Plant-veterinary antibiotic interaction has been widely studied, however, to the best of our knowledge acclimatization studies with regard to changes in plant root metabolites has not been reported so far. The purpose of this study was to examine the changes in the metabolome of pea roots under antibiotic stress and their role in acclimatization. Pisum sativum L. was grown in soil contaminated with three commonly used veterinary antibiotics - kanamycin (KA), sulfamethazine (SA), and tetracycline (TC). In response to antibiotic stress, plants accumulated different types of low molecular weight compounds that provided protection from stress by contributing to ROS detoxification, protection of membrane integrity, efficient signaling, cell wall function, and cellular osmotic adjustment (glucose, galactose, myo-inositol, stigmasterol, octadecadienoic acid, l-proline)...
April 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660996/annals-express-a-case-of-hereditary-coproporphyria-with-posterior-reversible-encephalopathy-and-novel-cpox-gene-mutation-c-863t-g-p-leu288trp
#2
Deborah Lambie, Christopher M Florkowski, Chris Sies, Anthony Raizis, Wai-Kwan Siu, Cindy Towns
A 21 year old female had recurrent presentations to the Emergency Department (ED) with myalgia, vomiting, abdominal pain and subsequently developed generalized seizures. She was volume depleted with a plasma sodium of 125 mmol/L (reference interval 135-145) and she had fluctuating hypertension. Acute porphyria was suspected and confirmed with raised urine porphobilinogen (PBG)/creatinine ratio of 12·4 umol/mmol (reference interval < 1·5) and she was treated with intravenous haem arginate. Urinary porphyrin/creatinine ratio was 673 nmol/mmol, (reference interval <35) and faecal porphyrins 2430 umol/kg dry weight (reference interval <200) were markedly elevated, with raised faecal CIII:CI ratio, consistent with acute coproporphyria...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29656440/in-plane-superresolution-mri-with-phaseless-sub-pixel-encoding
#3
Franciszek Hennel, Rui Tian, Maria Engel, Klaas P Pruessmann
PURPOSE: Acquisition of high-resolution imaging data using multiple excitations without the sensitivity to fluctuations of the transverse magnetization phase, which is a major problem of multi-shot MRI. THEORY AND METHODS: The concept of superresolution MRI based on microscopic tagging is analyzed using an analogy with the optical method of structured illumination. Sinusoidal tagging is shown to provide subpixel resolution by mixing of neighboring spatial frequency (k-space) bands...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29650316/seesway-a-free-web-based-system-for-analysing-and-exploring-standing-balance-data
#4
Ross A Clark, Yong-Hao Pua
BACKGROUND AND OBJECTIVES: Computerised posturography can be used to assess standing balance, and can predict poor functional outcomes in many clinical populations. A key limitation is the disparate signal filtering and analysis techniques, with many methods requiring custom computer programs. This paper discusses the creation of a freely available web-based software program, SeeSway (www.rehabtools.org/seesway), which was designed to provide powerful tools for pre-processing, analysing and visualising standing balance data in an easy to use and platform independent website...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29649080/investigating-changes-in-weight-and-body-composition-among-women-in-adjuvant-treatment-for-breast-cancer-a-scoping-review
#5
Birgith Pedersen, Charlotte Delmar, Tamás Lörincz, Ursula Falkmer, Mette Grønkjær
BACKGROUND: Despite several investigations, findings on weight changes during and after adjuvant treatment for breast cancer are diverse and point in several directions. OBJECTIVE: The aims of this study were to investigate changes in weight and body composition associated with contemporary anticancer medication and to examine factors that might influence the assessment and diversity of the findings. METHODS: This article used the method of a scoping review to map the body of literature...
April 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29629563/changes-in-collegiate-ice-hockey-player-anthropometrics-and-aerobic-fitness-over-three-decades
#6
Ashley N Triplett, Amy C Ebbing, Matthew R Green, Christopher P Connolly, David P Carrier, James M Pivarnik
Over the past several decades, an increased emphasis on fitness training has emerged among collegiate ice hockey teams, with the objective to improve on-ice performance. However, it is unknown if this increase in training has translated over time to changes in anthropometric and fitness profiles of collegiate ice hockey players. The purposes of this study were to describe anthropometric (height, weight, BMI, %fat) and aerobic fitness (VO<sub>2peak</sub>) characteristics of collegiate ice hockey players over 36 years, and to evaluate whether these characteristics differ between player positions...
April 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29626028/lesson-of-the-month-2-a-rare-presentation-of-stroke-diagnosis-made-on-magnetic-resonance-imaging
#7
Danielle Berenson, Luke Nuttall, Eluzai Hakim, Khaled Abdel-Aziz
Bilateral thalamic infarcts are uncommon posterior circulation strokes. The artery of Percheron (AOP) is a rare anatomical variant involving a singular arterial supply to both thalami and occlusion leads to bilateral thalamic infarction.We report the case of a 71-year-old man who presented with decreased consciousness (fluctuating Glasgow Coma Scale score of 5-7). He had a background of atrial fibrillation and was anticoagulated with dabigatran, a novel oral anticoagulant. Computed tomography (CT) scan showed a mildly reduced attenuation in the region of the left thamalus...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29615483/incidence-of-hypocapnia-hypercapnia-and-acidosis-and-the-associated-risk-of-adverse-events-in-preterm-neonates
#8
Melissa K Brown, Deborah M Poeltler, Kasim O Hassen, Danielle V Lazarus, Vanessa K Brown, Jeremiah J Stout, Wade D Rich, Anup C Katheria
BACKGROUND: Permissive hypercapnia is a lung-protection strategy. We sought to review our current clinical practice for the range of permissive hypercapnia and identify the relationship between P aCO2 and pH and adverse outcomes. METHODS: A secondary analysis of a delayed cord-clamping clinical trial was performed on all arterial blood gas tests in the first 72 h in infants < 32 weeks gestational age. All arterial blood gas values were categorized into a clinical range to determine the percent likelihood of occurring in the total sample...
April 3, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29603547/continuous-glucose-monitoring-during-diabetic-pregnancy-glucomoms-a-multicentre-randomised-controlled-trial
#9
Daphne N Voormolen, J Hans DeVries, Rieneke M E Sanson, Martijn P Heringa, Harold W de Valk, Marjolein Kok, Aren J van Loon, Klaas Hoogenberg, Dick J Bekedam, Teri C B Brouwer, Martina Porath, Ronald J Erdtsieck, Bas NijBijvank, Huib Kip, Olivier W H van der Heijden, Lammy D Elving, Brenda B Hermsen, B J Potter van Loon, Robert J P Rijnders, Henry J Jansen, Josje Langenveld, Bettina M C Akerboom, Rosalie M Kiewiet, Christiana A Naaktgeboren, Ben W J Mol, Arie Franx, Inge M Evers
AIM: Diabetes is associated with a high risk for adverse pregnancy outcomes. Optimal glycaemic control is fundamental and is traditionally monitored with self-measured glucose profiles and periodical HbA1c measurements. We investigated the effectiveness of additional use of retrospective Continuous Glucose Monitoring (CGM) in diabetic pregnancies. MATERIAL AND METHODS: We performed a nation wide multicentre open label randomised controlled trial studying pregnant women with type 1 diabetes, or type 2 diabetes on insulin therapy with gestational age <16 weeks, or insulin treated gestational diabetes with gestational age <30 weeks...
March 30, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29603077/minimal-water-volume-for-intensively-producing-male-siamese-fighting-fish-betta-splendens-regan-1910
#10
Suktianchai Saekhow, Karun Thongprajukaew, Wutiporn Phromkunthong, Harit Sae-Khoo
Water volume is a key parameter affecting the individual rearing of male Siamese fighting fish (Betta splendens Regan, 1910). In this study, minimization of water volume was pursued by assessing growth, feed utilization, digestive enzyme activities, color coordinates, muscle quality, and carcass composition. One-month-old solid-red male fish (0.97 ± 0.01 g initial body weight) were distributed individually into glass aquaria with five alternative water volumes (100, 150, 200, 250, and 300 mL), comprising 15 fish per treatment (n = 15), over 8 weeks duration...
March 30, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29580177/sensor-triggered-sampling-to-determine-instantaneous-airborne-vapor-exposure-concentrations
#11
Philip A Smith, Michael K Simmons, Phillip Toone
It is difficult to measure transient airborne exposure peaks by means of integrated sampling for organic chemical vapors, even with very short-duration sampling. Selection of an appropriate time to measure an exposure peak through integrated sampling is problematic, and short-duration time-weighted average (TWA) values obtained with integrated sampling are not likely to accurately determine actual peak concentrations attained when concentrations fluctuate rapidly. Laboratory analysis for integrated exposure samples is preferred from a certainty standpoint over results derived in the field from a sensor, as a sensor user typically must overcome specificity issues and a number of potential interfering factors to obtain similarly reliable data...
March 26, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29561130/metabolite-biometrics-for-the-differentiation-of-individuals
#12
Mindy Elizabeth Hair, Adrianna I Mathis, Erica K Brunelle, Lenka Halámková, Jan Halámek
Sweat is a biological fluid present on the skin surface of every individual and is known to contain amino acids as well as other low molecular weight compounds. Each individual is inherently different from one another based on certain factors including, but not limited to, his/her genetic make-up, environment, and lifestyle. As such, the biochemical composition of each person greatly differs. The concentrations of the biochemical content within an individual's sweat are largely controlled by metabolic processes within the body that fluctuate regularly based on attributes such as age, gender, and activity levels...
March 21, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29558425/the-influence-of-high-and-low-doses-of-bisphenol-a-bpa-on-the-enteric-nervous-system-of-the-porcine-ileum
#13
Kamila Szymanska, Krystyna Makowska, Slawomir Gonkowski
Bisphenol A, used in the production of plastic, is able to leach from containers into food and cause multidirectional adverse effects in living organisms, including neurodegeneration and metabolic disorders. Knowledge of the impact of BPA on enteric neurons is practically non-existent. The destination of this study was to investigate the influence of BPA at a specific dose (0.05 mg/kg body weight/day) and at a dose ten times higher (0.5 mg/kg body weight/day), given for 28 days, on the porcine ileum. The influence of BPA on enteric neuron immunoreactive to selected neuronal active substances, including substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL), vesicular acetylcholine transporter (VAChT-used here as a marker of cholinergic neurons), and cocaine- and amphetamine-regulated transcript peptide (CART), was studied by the double immunofluorescence method...
March 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29544682/intermittent-hypoxia-suppression-of-growth-hormone-and-insulin-like-growth-factor-i-in-the-neonatal-rat-liver
#14
Charles Cai, Taimur Ahmad, Gloria B Valencia, Jacob V Aranda, Jiliu Xu, Kay D Beharry
OBJECTIVES: Extremely low gestational age neonates with chronic lung disease requiring oxygen therapy frequently experience fluctuations in arterial oxygen saturation or intermittent hypoxia (IH). These infants are at risk for multi-organ developmental delay, reduced growth, and short stature. The growth hormone (GH)/insulin-like growth factor-I (IGF-1) system, an important hormonal regulator of lipid and carbohydrate metabolism, promotes neonatal growth and development. We tested the hypothesis that increasing episodes of IH delay neonatal growth by influencing the GH/IGF-I axis...
March 8, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29539393/escape-of-a-small-molecule-from-inside-t4-lysozyme-by-multiple-pathways
#15
Ariane Nunes-Alves, Daniel M Zuckerman, Guilherme Menegon Arantes
The T4 lysozyme L99A mutant is often used as a model system to study small-molecule binding to proteins, but pathways for ligand entry and exit from the buried binding site and the associated protein conformational changes have not been fully resolved. Here, molecular dynamics simulations were employed to model benzene exit from its binding cavity using the weighted ensemble (WE) approach to enhance sampling of low-probability unbinding trajectories. Independent WE simulations revealed four pathways for benzene exit, which correspond to transient tunnels spontaneously formed in previous simulations of apo T4 lysozyme...
March 13, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29522676/interactions-of-soil-species-exposed-to-cuo-nms-are-different-from-cu-salt-a-multispecies-test
#16
Luis A Mendes, Mónica Jb Amorim, Janeck J Scott-Fordsmand
Although environmental effects are mostly assessed via standard individual species the ecological relevance of multispecies testing is well-recognised and highly recommended. Hence, the effect of copper oxide nanomaterials (CuONM) and CuCl2 were assessed using the validated soil multispecies system (SMS). Besides the individual species (IS) "standard" tests for all, a predation study was done. Toxicity was higher in the SMS than in the IS, and longer exposure showed increased toxicity. The predator (Hypoaspis aculeifer) preyed most on smaller species, but the net biomass consumed was similar across species...
March 9, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29519542/point-of-care-fecal-calprotectin-monitoring-in-preterm-infants-at-risk-for-necrotizing-enterocolitis
#17
Warapan Nakayuenyongsuk, Megan Christofferson, David K Stevenson, Karl Sylvester, Henry C Lee, K T Park
OBJECTIVE: To establish baseline trends in fecal calprotectin, a protein excreted into the stool when there is neutrophilic inflammation in the bowel, in infants at risk for necrotizing enterocolitis (NEC). STUDY DESIGN: We performed a prospective observational cohort study in infants with a birth weight of <1500 g without existing bowel disease at a level IV neonatal intensive care unit from October 2015 to September 2016. Stools were collected once daily for 30 days or until 32 weeks postmenstrual age and processed using the Fecal Calprotectin High Range Quantitative Quantum Blue assay...
March 6, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29510759/on-the-suitability-of-an-allometric-proxy-for-nondestructive-estimation-of-average-leaf-dry-weight-in-eelgrass-shoots-i-sensitivity-analysis-and-examination-of-the-influences-of-data-quality-analysis-method-and-sample-size-on-precision
#18
Héctor Echavarría-Heras, Cecilia Leal-Ramírez, Enrique Villa-Diharce, Nohe Cazarez-Castro
BACKGROUND: The effects of current anthropogenic influences on eelgrass (Zostera marina) meadows are noticeable. Eelgrass ecological services grant important benefits for mankind. Preservation of eelgrass meadows include several transplantation methods. Evaluation of establishing success relies on the estimation of standing stock and productivity. Average leaf biomass in shoots is a fundamental component of standing stock. Existing methods of leaf biomass measurement are destructive and time consuming...
March 6, 2018: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29508275/eadsg-guidelines-insulin-therapy-in-diabetes
#19
Bahendeka Silver, Kaushik Ramaiya, Swai Babu Andrew, Otieno Fredrick, Sarita Bajaj, Sanjay Kalra, Bavuma M Charlotte, Karigire Claudine, Anthony Makhoba
A diagnosis of diabetes or hyperglycemia should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) (A). Typically, patients with T1DM will require initiation with multiple daily injections at the time of diagnosis. This is usually short-acting insulin or rapid-acting insulin analogue given 0 to 15 min before meals together with one or more daily separate injections of intermediate or long-acting insulin...
April 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29504944/a-novel-metastable-state-magnetic-phase-of-monolayer-fese
#20
Lijun Meng, Jun Yu, Haiyan Peng, Yanru Li, Jianxin Zhong
We found a novel metastable magnetic phase by systematically calculating total energy of monolayer FeSe in various antiferromagnetic (AFM) orders using first-principles method. The new metastable magnetic phase named as QAFM is a magnetic state with short-range magnetic structure which can be regarded as a transitional state between checkerboard-like antiferromagnetic state and collinear antiferromagnetic state. Both magnetic moments with important fluctuation and charge density difference with a 24 reconstruction of orbitals breaks C4 symmetry and maybe commonly corresponds to the nematic phase in recent transmission electron microscopy (TEM) and neutron scattering experiment observations...
March 5, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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