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https://www.readbyqxmd.com/read/29054379/treatment-log-files-as-a-tool-to-identify-treatment-plan-sensitivity-to-inaccuracies-in-scanned-proton-beam-delivery
#1
Maria Francesca Belosi, Robert van der Meer, Paz Garcia de Acilu Laa, Alessandra Bolsi, Damien C Weber, Antony J Lomax
Dose distributions delivered at Gantry 2 at the Paul Scherrer Institut (PSI) can be reconstructed on the patient anatomy based on machine log files. With the present work, the dependency of the log file calculation on the planning optimization technique and on other planning parameters, such as field direction and tumour size, has been investigated. Interestingly, and despite the typically higher modulation of Intensity Modulated Proton Therapy (IMPT) plans, the results for both Single Field Uniform Distribution and IMPT approaches have been found to be similar...
October 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29053315/shear-modulus-and-shear-stress-fluctuations-in-polymer-glasses
#2
I Kriuchevskyi, J P Wittmer, H Meyer, J Baschnagel
Using molecular dynamics simulation of a standard coarse-grained polymer glass model, we investigate by means of the stress-fluctuation formalism the shear modulus μ as a function of temperature T and sampling time Δt. While the ensemble-averaged modulus μ(T) is found to decrease continuously for all Δt sampled, its standard deviation δμ(T) is nonmonotonic, with a striking peak at the glass transition. Confirming the effective time-translational invariance of our systems, μ(Δt) can be understood using a weighted integral over the shear-stress relaxation modulus G(t)...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29051826/apparent-and-standardized-ileal-nutrient-digestibility-of-broiler-diets-containing-varying-levels-of-raw-full-fat-soybean-and-microbial-protease
#3
Mammo M Erdaw, Rider A Perez-Maldonado, Paul A Iji
BACKGROUND: Although soybean meal (SBM) is excellent source of protein in diets for poultry, it is sometimes inaccessible, costly and fluctuates in supply. The SBM can partially be replaced by full-fat SBM, but the meals prepared from raw full-fat soybean contain antinutritional factors. To avoid the risk of antinutritional factors, heat treatment is always advisable, but either excessive or under heating the soybean could negatively affect the quality. However, the potential for further improvement of SBM by supplementing with microbial enzymes has been suggested by many researchers...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/29050885/does-attentional-dysfunction-and-thalamic-atrophy-predict-decline-in-dementia-with-lewy-bodies
#4
Rosie Watson, Sean J Colloby, Andrew M Blamire, Keith A Wesnes, Josh Wood, John T O'Brien
INTRODUCTION: To evaluate the clinical characteristics of DLB subjects who died within 1 year of assessment compared to those who survived and investigate their patterns of in vivo regional thalamic atrophy using structural MRI. METHODS: Seventy subjects (35 DLB, 35 aged controls) underwent 3 T T1-weighted MR scanning as well as clinical and cognitive assessments, including a computerised assessment of attention. All subjects were contacted after 12 months for reassessment...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29050704/patterns-of-food-avoidance-and-eating-behavior-in-women-with-fibromyalgia
#5
María Mar López-Rodríguez, José Granero Molina, Isabel María Fernández Medina, Cayetano Fernández Sola, Alicia Ruiz Muelle
INTRODUCTION: Fibromyalgia is a form of non-articular rheumatic disorder of unknown origin. It is characterized by widespread, chronic musculoskeletal pain. Patients with fibromyalgia suffer more frequently eating disorders, obesity, metabolic syndrome, and other gastrointestinal symptoms. Studies have pointed out to nutrition as a relevant factor in these patients. Some of them think that diet has an influence on fibromyalgia symptoms, and tend to adopt certain dietary patterns. This, combined with access to non-scientific information about diets and supplements, makes analysis of dietary behavior, avoidance, and restrictions particularly important...
November 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/29037498/levodopa-carbidopa-intestinal-gel-in-advanced-parkinson-s-final-results-of-the-gloria-registry
#6
Angelo Antonini, Werner Poewe, K Ray Chaudhuri, Robert Jech, Barbara Pickut, Zvezdan Pirtošek, Jozsef Szasz, Francesc Valldeoriola, Christian Winkler, Lars Bergmann, Ashley Yegin, Koray Onuk, David Barch, Per Odin
INTRODUCTION: This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. METHODS: Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. Observations were fully prospective for treatment-naïve patients (60% of patients) and partially retrospective for patients with ≤12 months of pre-treatment with LCIG (40% of patients)...
September 22, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29037407/serum-concentrations-of-free-amino-acids-in-growing-pigs-exposed-to-diurnal-heat-stress-fluctuations
#7
Miguel Cervantes, Nely Ibarra, Nydia Vásquez, Francisco Reyes, Ernesto Avelar, Salvador Espinoza, Adriana Morales
In areas where the ambient temperature (AT) is above the thermo neutral (TN) zone of pigs, significant changes within a 24-h period occur, differently affecting the availability of amino acids (AA) within the same day. An experiment was conducted to analyze the serum concentrations (SC) of free AA in pigs exposed to diurnal variations in AT. Six pigs (27.1 ±1.3kg body weight) implanted with a thermometer to register the body temperature (BT) at 15-min intervals were used. Blood samples were collected on the last 3 d of the 14-d study, at 0700h (lowest AT), 1200h (mild HS), and 1600h (severe HS)...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29036164/crossing-statistics-of-laser-light-scattered-through-a-nanofluid
#8
M Arshadi Pirlar, S M S Movahed, D Razzaghi, R Karimzadeh
In this paper, we investigate the crossing statistics of speckle patterns formed in the Fresnel diffraction region by a laser beam scattering through a nanofluid. We extend zero-crossing statistics to assess the dynamical properties of the nanofluid. According to the joint probability density function of laser beam fluctuation and its time derivative, the theoretical frameworks for Gaussian and non-Gaussian regimes are revisited. We count the number of crossings not only at zero level but also for all available thresholds to determine the average speed of moving particles...
September 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29031250/communication-relaxation-limited-electronic-currents-in-extended-reservoir-simulations
#9
Daniel Gruss, Alex Smolyanitsky, Michael Zwolak
Open-system approaches are gaining traction in the simulation of charge transport in nanoscale and molecular electronic devices. In particular, "extended reservoir" simulations, where explicit reservoir degrees of freedom are present, allow for the computation of both real-time and steady-state properties but require relaxation of the extended reservoirs. The strength of this relaxation, γ, influences the conductance, giving rise to a "turnover" behavior analogous to Kramers turnover in chemical reaction rates...
October 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29031112/quantitative-analysis-of-antithrombin-iii-binding-site-in-low-molecular-weight-heparins-by-exhausetive-heparinases-digestion-and-capillary-electrophoresis
#10
Mingyu Zhang, Gong Li, Yi Zhang, Jingwu Kang
The antithrombin III (ATIII)-binding site, which contains a special 3-O-sulfated, N-sulfated glucosamine residue with or without 6-O-sulfation, is mainly responsible for the anticoagulant activity of heparin. Undergoing the chemical depolymerization process, the preservation of the ATIII-binding site in low molecular weight heparins (LMWHs) are varied leading to the fluctuation of the anticoagulant activity. Herein we report a capillary electrophoresis (CE) method in combination with heparinase digestion and affinity chromatography for the measurement of molar percentage of ATIII-binding site of LMWHs...
October 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29027521/wing-and-body-kinematics-measurement-and-force-analyses-of-landing-in-fruit-flies
#11
Chong Shen, Mao Sun
In this paper, we analyzed the body and wing kinematics and mechanics in fruit flies' landings on a vertical pole. By high-speed video techniques and CFD method, we exhibited the detailed process of landing as follows. A fruit fly first decelerates and enters a near-hover state approximately 25 mm away from the vertical pole, then starts approaching the pole in acceleration till one of its front-legs touches the pole (touchdown). Just before touchdown, the fly's acceleration is around 6 ms<sup>-2</sup>; at touchdown, it experiences an almost instant deceleration of several g (gravitational acceleration), approximately all of which results from the leg force...
October 13, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29021552/lifshitz-transition-from-valence-fluctuations-in-ybal3
#12
Shouvik Chatterjee, Jacob P Ruf, Haofei I Wei, Kenneth D Finkelstein, Darrell G Schlom, Kyle M Shen
In mixed-valent Kondo lattice systems, such as YbAl3, interactions between localized and delocalized electrons can lead to fluctuations between two different valence configurations with changing temperature or pressure. The impact of this change on the momentum-space electronic structure is essential for understanding their emergent properties, but has remained enigmatic. Here, by employing a combination of molecular beam epitaxy and in situ angle-resolved photoemission spectroscopy we show that valence fluctuations can lead to dramatic changes in the Fermi surface topology, even resulting in a Lifshitz transition...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29017769/modified-kernel-principal-component-analysis-using-double-weighted-local-outlier-factor-and-its-application-to-nonlinear-process-monitoring
#13
Xiaogang Deng, Lei Wang
Traditional kernel principal component analysis (KPCA) based nonlinear process monitoring method may not perform well because its Gaussian distribution assumption is often violated in the real industrial processes. To overcome this deficiency, this paper proposes a modified KPCA method based on double-weighted local outlier factor (DWLOF-KPCA). In order to avoid the assumption of specific data distribution, local outlier factor (LOF) is introduced to construct two LOF-based monitoring statistics, which are used to substitute for the traditional T(2) and SPE statistics, respectively...
October 7, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28982268/neonatal-mortality-in-jordan-secondary-analysis-of-jordan-population-and-family-health-survey-jpfhs-data
#14
Nail Obeidat, Yousef Khader, Anwar Batieha, Nadin Abdel Razeq, Nihaya Al-Sheyab, Mohammad Khassawneh
OBJECTIVE: This study aimed to analyze the 2009 Jordan Population and Family Health Survey (JPFHS) data to determine the level, trend, and distribution of neonatal mortality (NNM) in Jordan and determine its associated factors. METHODS: Nationally representative data on NNM were extracted from the JPFHS data. Using multivariate analyses, the strength of associations between 12 clinical/sociodemographic variables and neonatal mortality were quantified after controlling for potential confounders...
October 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28976897/glycemic-variability-and-vascular-complications-in-patients-with-type-2-diabetes-mellitus
#15
Martin Caprnda, Dasa Mesarosova, Pablo Fabuel Ortega, Boris Krahulec, Emmanuel Egom, Luis Rodrigo, Peter Kruzliak, Ioana Mozos, Ludovit Gaspar
BACKGROUND: Presence of macro- and microvascular complications in patients with diabetes mellitus (DM) is not only related to chronic hyperglycemia represented by glycated hemoglobin (HbA1c) but also to acute glycemic fluctuations (glycemic variability, GV). The association between GV and DM complications is not completely clear. Aim of our study was to evaluate GV by MAGE index in patients with type 2 DM and to verify association of MAGE index with presence of macro- and microvascular DM complications...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28976324/data-driven-robust-m-ls-svr-based-narx-modeling-for-estimation-and-control-of-molten-iron-quality-indices-in-blast-furnace-ironmaking
#16
Ping Zhou, Dongwei Guo, Hong Wang, Tianyou Chai
Optimal operation of an industrial blast furnace (BF) ironmaking process largely depends on a reliable measurement of molten iron quality (MIQ) indices, which are not feasible using the conventional sensors. This paper proposes a novel data-driven robust modeling method for the online estimation and control of MIQ indices. First, a nonlinear autoregressive exogenous (NARX) model is constructed for the MIQ indices to completely capture the nonlinear dynamics of the BF process. Then, considering that the standard least-squares support vector regression (LS-SVR) cannot directly cope with the multioutput problem, a multitask transfer learning is proposed to design a novel multioutput LS-SVR (M-LS-SVR) for the learning of the NARX model...
September 29, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28974453/cortical-cores-in-network-dynamics
#17
REVIEW
F de Pasquale, M Corbetta, V Betti, S Della Penna
Spontaneous brain activity at rest is spatially and temporally organized in networks of cortical and subcortical regions specialized for different functional domains. Even though brain networks were first studied individually through functional Magnetic Resonance Imaging, more recent studies focused on their dynamic 'integration'. Integration depends on two fundamental properties: the structural topology of brain networks and the dynamics of functional connectivity. In this scenario, cortical hub regions, that are central regions highly connected with other areas of the brain, play a fundamental role in serving as way stations for network traffic...
September 30, 2017: NeuroImage
https://www.readbyqxmd.com/read/28967972/in-search-of-a-good-night-s-sleep
#18
Laura G Leahy
A good night's sleep is essential to overall physical, cognitive, and emotional well-being. Sleep deprivation, whether general or related to time changes (e.g., daylight saving time), contributes to decreased cognition, impaired memory, poor coordination, mood fluctuations, increased risk of heart disease and diabetes, and weight gain, among others. The sleep cycle is defined by five stages and two distinct parts-rapid eye movement (REM) and non-REM sleep-that work to promote not only the quantity of sleep but also the quality of sleep, which impacts overall health...
October 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28964039/on-the-fly-analysis-of-molecular-dynamics-simulation-trajectories-of-proteins-using-the-bayesian-inference-method
#19
Naoyuki Miyashita, Yasushige Yonezawa
Robust and reliable analyses of long trajectories from molecular dynamics simulations are important for investigations of functions and mechanisms of proteins. Structural fitting is necessary for various analyses of protein dynamics, thus removing time-dependent translational and rotational movements. However, the fitting is often difficult for highly flexible molecules. Thus, to address the issues, we proposed a fitting algorithm that uses the Bayesian inference method in combination with rotational fitting-weight improvements, and the well-studied globular protein systems trpcage and lysozyme were used for investigations...
September 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28963852/advanced-and-amplified-bold-fluctuations-in-high-grade-gliomas
#20
Lalit Gupta, Rakesh K Gupta, Alida A Postma, Prativa Sahoo, Pradeep K Gupta, Rana Patir, Sunita Ahlawat, Indrajit Saha, Walter H Backes
BACKGROUND: Glioma grade along with patient's age and general health are used for treatment planning and prognosis. PURPOSE: To characterize and quantify the spontaneous blood oxygen level-dependent (BOLD) fluctuations in gliomas using measures based on T2*-weighted signal time-series and to distinguish between high- and low-grade gliomas. STUDY TYPE: Retrospective. SUBJECTS: Twenty-one patients with high-grade and 13 patients with low-grade gliomas confirmed on histology were investigated...
September 30, 2017: Journal of Magnetic Resonance Imaging: JMRI
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