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Alejandra Navarro, Rita Puig, Elena Martí, Alba Bala, Pere Fullana-I-Palmer
Production and consumption of olive oil is very important in Europe, being this product a basic element in the Mediterranean diet since long ago. The project objective is two-fold: a study of the contribution of virgin olive oils (VOOs) usual packaging to the whole life cycle of the product and a study of the environmental consequences of the Spanish Government regulation on VOO packaging. A life cycle assessment (LCA) according to ISO 14044 has been performed using the CML methodology for the impact assessment...
April 12, 2018: Environmental Management
Rayleen M Lewis, Lauri E Markowitz
BACKGROUND: Human papillomavirus (HPV) vaccination has been routinely recommended at age 11-12 years in the United States for females since 2006 and males since 2011. Coverage can be estimated using self/parent-reported HPV vaccination collected in the National Health and Nutrition Examination Survey (NHANES) for a wider age range than other national surveys. We assessed vaccination coverage in 2015-2016, temporal trends by age, and the validity of self/parent-reported vaccination status...
April 9, 2018: Vaccine
Samara M A Alexandre, Maria L Corradi da Silva, Ana F D Vasconcelos, Diego T D Exposti, Cesar A Tischer, Alicia Prieto, Dolores Diaz, Ramon Kaneno
A fucomannogalactan from Rhizoctonia solani biomass was obtained after hot aqueous extraction and purified by freeze-thaw cycles and gel filtration chromatography on Sepharose CL-6B. The polysaccharide was homogeneous after HPSEC/RID analysis (Mw /Mn  ~ 1.1), displaying an average molecular weight of 15.4 × 103  Da. Its chemical structure was determined by methylation analysis (GC/MS) and spectroscopy (FTIR, 1D and 2D NMR). The polysaccharide had a branched α-1,6-linked Galp backbone with 66% linear residues, a number of which were at O-3 methylated...
April 9, 2018: International Journal of Biological Macromolecules
Justin Shumate, Pierre Baillargeon, Timothy P Spicer, Louis Scampavia
Critical to maintaining quality control in high-throughput screening is the need for constant monitoring of liquid-dispensing fidelity. Traditional methods involve operator intervention with gravimetric analysis to monitor the gross accuracy of full plate dispenses, visual verification of contents, or dedicated weigh stations on screening platforms that introduce potential bottlenecks and increase the plate-processing cycle time. We present a unique solution using open-source hardware, software, and 3D printing to automate dispenser accuracy determination by providing real-time dispense weight measurements via a network-connected precision balance...
April 1, 2018: SLAS Technology
Kanu Shil, Sudipta Pal
Background: Hexavalent chromium [Cr(VI)], an environmental pollutant that originates mostly from anthropogenic sources, is a serious threat to human health. After entering into cells, Cr(VI) is capable of producing excessive free radicals and causing tissue damage. The present study aims to reveal the toxic manifestation of Cr(VI) on the metabolic activity of renal tissue. Methods: Male Swiss albino mice were treated orally with potassium dichromate (K2 Cr2 O7 ) at a dose of 10 mg/kg body weight for a period of 30 days...
April 2018: Clinical Kidney Journal
Nadine Mengis, Antti-Ilari Partanen, Jonathan Jalbert, H Damon Matthews
Estimates of the 1.5 °C carbon budget vary widely among recent studies, emphasizing the need to better understand and quantify key sources of uncertainty. Here we quantify the impact of carbon cycle uncertainty and non-CO2 forcing on the 1.5 °C carbon budget in the context of a prescribed 1.5 °C temperature stabilization scenario. We use Bayes theorem to weight members of a perturbed parameter ensemble with varying land and ocean carbon uptake, to derive an estimate for the fossil fuel (FF) carbon budget of 469 PgC since 1850, with a 95% likelihood range of (411,528) PgC...
April 11, 2018: Scientific Reports
Rachel Z Fraser, Mithila Shitut, Puja Agrawal, Odete Mendes, Sue Klapholz
The leghemoglobin protein (LegH) from soy ( Glycine max) expressed in Pichia pastoris (LegH preparation, LegH Prep) imparts a meat-like flavor profile onto plant-based food products. The safety of LegH Prep was evaluated through a series of in vitro and in vivo tests. The genotoxic potential of LegH Prep was assessed using the bacterial reverse mutation assay (Ames test) and the in vitro chromosome aberration test. LegH Prep was nonmutagenic and nonclastogenic in each test, respectively. Systemic toxicity was assessed in a 28-day dietary study in male and female Sprague Dawley rats...
January 1, 2018: International Journal of Toxicology
Alessandro Ruggiero, Massimiliano Merola, Saverio Affatato
The hip joint replacement is one of the most successful orthopedic surgical procedures although it involves challenges to overcome. The patient group undergoing total hip arthroplasty now includes younger and more active patients who require a broad range of motion and a longer service lifetime for the replacement joint. It is well known that wear tests have a long duration and they are very expensive, thus studying the effects of geometry, loading, or alignment perturbations may be performed by Finite Element Analysis...
April 9, 2018: Materials
X Gao, H Li, J-X Wei
OBJECTIVE: Preeclampsia is a serious disease that affects maternal and fetal health in pregnancy. Mechanism of miRNA in preeclampsia has gradually been explored. This study mainly investigated the mechanism of miR-4421 in preeclampsia. PATIENTS AND METHODS: The expression of miR-4421 in 42 preeclampsia tissues and 42 normal pregnancy placentas tissues was detected by qRT-PCR. The relationship between the miR-4421 level and clinicopathological features of preeclampsia was analyzed...
March 2018: European Review for Medical and Pharmacological Sciences
Hee-Jin Jeon, Yiseul Yeom, Yoo-Sun Kim, Eunju Kim, Jae-Ho Shin, Pu Reum Seok, Moon Jea Woo, Yuri Kim
BACKGROUND/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model. MATERIALS/METHODS: Male BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval...
April 2018: Nutrition Research and Practice
Yajie Chen, Xue Jiang, Hongqing Xie, Xiaotong Li, Liangen Shi
This study investigated the chemical characterization and antitumor effects of a polysaccharide from ramulus mori. A water-soluble polysaccharide, RMP1 with the estimated molecular weight of 137 kDa, was isolated and purified from ramulus mori through gel permeation chromatography. RMP1 is mainly composed of arabinose, xylose, glucose, galactose and rhamnose in a ratio of 0.56:0.37:0.17:1.00:0.08. Methylation and NMR analysis revealed that RMP1 had a backbone composed of 1,6-β-d-Galp, 1,3,6-β-d-Galp and 1,3-β-d-Galp residues, two main branches of 1,2-α-l-Araf, 1,3,6-β-d-Galp and 1,4-β-d-Xylp; it also had α-l-Araf and β-d-Glcp as terminals...
June 15, 2018: Carbohydrate Polymers
Patchiya Phanthong, Prasert Reubroycharoen, Suwadee Kongparakul, Chanatip Samart, Zhongde Wang, Xiaogang Hao, Abuliti Abudula, Guoqing Guan
Nanocellulose sponge was fabricated by a facile method: freeze-drying of nanocellulose aqueous suspension to sponge state, following by hydrophobic treatment with stearoyl chloride at 50 °C for 1 h. The obtained nanocellulose sponge showed superhydrophobicity (160° of water contact angle) and superoleophilicity with high protection from water but selective absorption of oil. Its absorption capacities for various kinds of oil and non-polar liquids were 25-55 times higher than its dry weight and exhibited excellent selectivity for absorbing of oil which spilled on the surface of water or underwater with high separation efficiency...
June 15, 2018: Carbohydrate Polymers
Daniel Marsland, Joanna M Stephen, Toby Calder, Andrew A Amis, James D F Calder
PURPOSE: To assess whether early rehabilitation could be safe after flexor digitorum longus (FDL) tendon transfer, the current biomechanical study aimed to measure tendon displacement under cyclic loading and load to failure, comparing a traditional tendon-to-tendon (TT) repair with interference screw fixation (ISF). METHODS: 24 fresh-frozen cadaveric below knee specimens underwent FDL tendon transfer. In 12 specimens a TT repair was performed via a navicular bone tunnel...
April 7, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
A L Garcia-Garcia, M Alvarez-Vera, L A Montoya-Santiyanes, I Dominguez-Lopez, J L Montes-Seguedo, J C Sosa-Savedra, J D O Barceinas-Sanchez
Friction is the natural response of all tribosystems. In a total knee replacement (TKR) prosthetic device, its measurement is hindered by the complex geometry of its integrating parts and that of the testing simulation rig operating under the ISO 14243-3:2014 standard. To develop prediction models of the coefficient of friction (COF) between AISI 316L steel and ultra-high molecular weight polyethylene (UHMWPE) lubricated with fetal bovine serum dilutions, the arthrokinematics and loading conditions prescribed by the ISO 142433: 2014 standard were translated to a simpler geometrical setup, via Hertz contact theory...
March 27, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Ho-Wei Wang, Duan-Rung Chen
BACKGROUND: Obesity is highly correlated with the development of chronic diseases and has become a critical public health issue that must be countered by aggressive action. This study determined whether data from Google Trends could provide insight into trends in obesity-related search behaviors in Taiwan. OBJECTIVE: Using Google Trends, we examined how changes in economic conditions-using business cycle indicators as a proxy-were associated with people's internet search behaviors related to obesity awareness, health behaviors, and fast food restaurants...
April 6, 2018: JMIR Public Health and Surveillance
Satoshi Ueno, Kazuo Uchiyama, Tomoko Kuroda, Akiko Yabuuchi, Kenji Ezoe, Tadashi Okimura, Takashi Okuno, Tamotsu Kobayashi, Keiichi Kato
A retrospective cohort study of 8736 autologous single vitrified-warmed blastocyst transfer cycles was conducted in a single centre to investigate the effect of cryostorage on clinical and neonatal outcomes. Cryostorage duration was classified into two groups: (A) 0-2 months (n = 4702); (B) 2-13 months (n = 2853) and (C) 13-97 months (n = 1181). Blastocysts were vitrified using the Cryotop method. No significant differences were observed in live birth rates: (A) 37.3%; (B) 34.9%; (C) (35.2%). Gestational period was significantly shorter in group C: (A) 38...
March 14, 2018: Reproductive Biomedicine Online
Mariia Pukalchik, Filip Mercl, Vera Terekhova, Pavel Tlustoš
We conducted a pot experiment with biochar (BC), wood ash (WA), and humic substances (HS) to investigate their effect on As, Zn, Cu, Cd and Pb mobility in soil, as well as enzyme activities involved in C-, N-, and P-cycles, and Eisenia foetida toxicity in multi-contaminated soils. Amendments were dosed to increase еру soil pH from initial 6.0 to ∼6.5 and ∼7.0. Applying amendments has revealed, that WA significantly immobilized Cu, Zn and Pb, BC - Cu and Zn, and HS decreased solely Cu mobility in soil...
March 28, 2018: Chemosphere
Wei Liu, Li Li, Hua Ye, Huan Tao, Huaqin He
Public transcriptome databases provide a valuable resource for genome‑wide co‑expression network analysis and investigation of the molecular mechanisms that underlie pathogenesis. To discover genes that may affect patient survival, a large‑scale analysis of human colorectal cancer (CRC) datasets that were retrieved from the NCBI Gene Expression Omnibus was performed. A gene co‑expression network was constructed using weighted gene co‑expression network analysis (WGCNA). A total of 18 co‑expressed gene modules were identified, of which two genes corresponded to cell migration and the cell cycle, two genes were involved in immune responses, two genes corresponded to mitochondrial function, and one gene corresponded to RNA splicing...
March 23, 2018: Oncology Reports
Bo-Ram Park, Seul Ah Lee, Sung Min Moon, Chun Sung Kim
Anthricin (deoxypodophyllotoxin) is a major lignan in Anthriscus sylvestris and possesses many bioactivities such as antiproliferative, antitumor, anti‑platelet aggregation, antiviral and anti‑inflammatory actions. However, the anticancer effects of anthricin on A549 human non‑small cell lung cancer cells and potential molecular mechanisms remain unknown. Therefore, we investigated the anticancer effect of anthricin and the underlying mechanism in A549 cells. Anthricin (10‑200 nM) inhibited the viability of A549 cells in a dose‑ and time‑dependent manner...
March 27, 2018: Oncology Reports
Shiori Yabe, Takashi Hara, Mariko Ueno, Hiroyuki Enoki, Tatsuro Kimura, Satoru Nishimura, Yasuo Yasui, Ryo Ohsawa, Hiroyoshi Iwata
To evaluate the potential of genomic selection (GS), a selection experiment with GS and phenotypic selection (PS) was performed in an allogamous crop, common buckwheat ( Fagopyrum esculentum Moench). To indirectly select for seed yield per unit area, which cannot be measured on a single-plant basis, a selection index was constructed from seven agro-morphological traits measurable on a single plant basis. Over 3 years, we performed two GS and one PS cycles per year for improvement in the selection index. In GS, a prediction model was updated every year on the basis of genotypes of 14,598-50,000 markers and phenotypes...
2018: Frontiers in Plant Science
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