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https://www.readbyqxmd.com/read/29458171/toxicology-studies-of-furosine-in-vitro-in-vivo-and-exploration-of-the-related-mechanism
#1
Hui-Ying Li, Lei Xing, Jia-Qi Wang, Nan Zheng
AIM: Furosine is one of the Maillard reaction products (MRPs) and is found in a variety of heat-processed food. Yet its toxicity is still unclear. The present study was designed to assess furosine toxicity in cell models and in CD-1 mice, respectively. METHODS: In vitro, the effects of furosine on the cell viability, cell cycle and apoptosis (Hek293, HepG2, SK-N-SH and Caco2) were detected and evaluated, sensitive cell lines and proper dosage of furosine for further animal experiment were determined, and the mechanisms of toxicity were explored...
February 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29457805/urinary-metabolomic-study-of-the-antagonistic-effect-of-p-ginseng-in-rats-with-estrogen-decline-using-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#2
He Lin, Zhongying Liu, Zifeng Pi, Lihui Men, Weijia Chen, Zhiqiang Liu
Estrogens are biologically active steroid hormones mainly released from the ovary by ovarian secretion of estrogen into the circulating blood to regulate or function at the distal target. Estrogens play an important role in the central nervous system, cardiovascular system and immune system, especially for post-menopausal women. Panax ginseng Mayer has been reported to relieve women's menopausal symptoms and affect estrogen activities. However, the mechanism of its estrogen regulation has not yet been clearly investigated...
February 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29457204/prevention-and-management-of-childhood-obesity
#3
Aashima Dabas, Anju Seth
Childhood obesity has been recognized as a global pandemic. Preventive strategies have proven to be the most effective public health intervention in curbing this pandemic. A multi-component approach involving dietary modification and advocacy for a healthy lifestyle comprising of regular physical activity, minimizing screen time and behavioral interventions have been found beneficial in preventing obesity. A life-cycle approach has been recommended where preventive interventions go as far back as affecting maternal, fetal and early childhood nutrition and lifestyle...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29456546/genome-wide-association-studies-and-comparison-of-models-and-cross-validation-strategies-for-genomic-prediction-of-quality-traits-in-advanced-winter-wheat-breeding-lines
#4
Peter S Kristensen, Ahmed Jahoor, Jeppe R Andersen, Fabio Cericola, Jihad Orabi, Luc L Janss, Just Jensen
The aim of the this study was to identify SNP markers associated with five important wheat quality traits (grain protein content, Zeleny sedimentation, test weight, thousand-kernel weight, and falling number), and to investigate the predictive abilities of GBLUP and Bayesian Power Lasso models for genomic prediction of these traits. In total, 635 winter wheat lines from two breeding cycles in the Danish plant breeding company Nordic Seed A/S were phenotyped for the quality traits and genotyped for 10,802 SNPs...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29454817/investigating-the-feasibility-of-a-reuse-scenario-for-textile-fibres-recovered-from-end-of-life-tyres
#5
Daniele Landi, Silvia Gigli, Michele Germani, Marco Marconi
The management of end-of-life tyres (ELTs) is regulated by several national and international legislations aiming to promote the recovery of materials and energy from this waste. The three main materials used in tyres are considered: rubber (main product), which is currently reused in other closed-loop applications; steel, which is used for the production of virgin materials; and textile fibres (approximately 10% by weight of ELTs), which are mainly incinerated for energy recovery (open-loop scenario). This study aims to propose and validate a new closed-loop scenario for textile fibres based on material reuse for bituminous conglomerates...
February 14, 2018: Waste Management
https://www.readbyqxmd.com/read/29454324/investigation-of-the-anti-cataractogenic-mechanisms-of-curcumin-through-in-vivo-and-in-vitro-studies
#6
Jing Cao, Tao Wang, Meng Wang
BACKGROUND: Cataract is the leading cause of blindness in elderly people worldwide, especially in developing countries. Studies to identify strategies that can prevent or retard cataract formation are urgently required. This study aimed to investigate the potential mechanism of the cytoprotective effects of curcumin in in vivo and in vitro experiments. METHODS: Male Wistar rats were randomly divided into three groups: the control group, the model group (administered 20 μmol/kg sodium selenite), and the curcumin group (pretreated with 75 mg/kg body weight curcumin 24 h prior to the administration of sodium selenite)...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29453627/a-phase-i-and-pharmacokinetic-study-of-taladegib-a-smoothened-inhibitor-in-japanese-patients-with-advanced-solid-tumors
#7
Hideki Ueno, Shunsuke Kondo, Shusuke Yoshikawa, Koichi Inoue, Valérie Andre, Masaomi Tajimi, Haruyasu Murakami
Background This phase I dose-escalation study investigated the safety of the Smoothened inhibitor taladegib in Japanese patients with advanced solid tumors. Methods Patients received taladegib orally once daily for 28-day cycles, using a 3 + 3 dose-escalation method. The primary objective was the safety and tolerability of taladegib at doses up to the global recommended dose (400 mg). Secondary objectives included pharmacokinetics, changes in skin glioma-associated oncogene homolog 1 (Gli1) transcript levels, and antitumor activity...
February 17, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29452975/associations-between-food-security-status-and-dietary-inflammatory-potential-within-lower-income-adults-from-the-united-states-national-health-and-nutrition-examination-survey-cycles-2007-to-2014
#8
Rachel S Bergmans, Mari Palta, Stephanie A Robert, Lawrence M Berger, Deborah B Ehrenthal, Kristen M Malecki
BACKGROUND: Evidence suggests both that chronic inflammation mediates the association of food insecurity with adverse health outcomes and that diet may be a significant source of inflammation among food insecure individuals. OBJECTIVE: To examine whether food security status is associated with dietary inflammatory potential. DESIGN AND PARTICIPANTS: Cross-sectional data came from the National Health and Nutrition Examination Survey (NHANES), cycles 2007 to 2014 (n=10,630)...
February 13, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29451784/alteration-of-crop-yield-and-quality-of-wheat-upon-exposure-to-silver-nanoparticles-in-a-life-cycle-study
#9
Jie Yang, Fuping Jiang, Chuanxin Ma, Yu-Kui Rui, Mengmeng Rui, Adeel Muhammad, Weidong Cao, Baoshan Xing
Due to the rapid development of nanotechnology, metal-based nanoparticles (NPs) are inadvertently released into environment and may pose a potential threat to ecosystem. However, information for food quality and safety in NP treated crops is limited. In the present study, wheat (Triticum aestivum L.) was grown in different concentrations of Ag NP amended soil (20, 200, and 2000 mg•kg-1) for four months. At harvest, physiological parameters, Ag and micronutrients (Fe, Cu, and Zn) content, as well as amino acid and protein contents were measured...
February 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29450936/correcting-for-missing-and-irregular-data-in-home-range-estimation
#10
C H Fleming, D Sheldon, W F Fagan, P Leimgruber, T Mueller, D Nandintsetseg, M J Noonan, K A Olson, E Setyawan, A Sianipar, J M Calabrese
Home-range estimation is an important application of animal tracking data that is frequently complicated by autocorrelation, sampling irregularity, and small effective sample sizes. We introduce a novel, optimal weighting method that accounts for temporal sampling bias in autocorrelated tracking data. This method corrects for irregular and missing data, such that oversampled times are downweighted and undersampled times are upweighted to minimize error in the home-range estimate. We also introduce computationally efficient algorithms that make this method feasible with large datasets...
February 16, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29446302/life-cycle-assessment-of-connected-and-automated-vehicles-sensing-and-computing-subsystem-and-vehicle-level-effects
#11
James H Gawron, Gregory A Keoleian, Robert D De Kleine, Timothy J Wallington, Hyung Chul Kim
Although recent studies of connected and automated vehicles (CAVs) have begun to explore the potential energy and greenhouse gas (GHG) emission impacts from an operational perspective, little is known about how the full life cycle of the vehicle will be impacted. We report the results of a life cycle assessment (LCA) of Level 4 CAV sensing and computing subsystems integrated into internal combustion engine vehicle (ICEV) and battery electric vehicle (BEV) platforms. The results indicate that CAV subsystems could increase vehicle primary energy use and GHG emissions by 3-20% due to increases in power consumption, weight, drag, and data transmission...
February 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29445408/needs-and-preferences-of-women-users-of-oral-contraceptives-in-selected-countries-in-central-and-eastern-europe
#12
Tomas Fait, Dmitry Buryak, Monica-Mihaela Cirstoiu, Eva Luczai, Rafal Janczura
Background: The availability of various oral contraceptive (OC) pill formulations with different hormone compositions suggests that there is potential to align a particular product with an individual user's needs and preferences. To explore this concept further, a survey was conducted of current users of OCs to define and confirm areas of specific needs, and to gain insight into their views and preferences for OC formulations. Methods: During November and December 2015, women users (n=615) of OCs in five Central and Eastern European countries were surveyed in face-to-face interviews conducted by experienced interviewers...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29445376/investigating-relationships-between-reproduction-immune-defenses-and-cortisol-in-dall-sheep
#13
Cynthia J Downs, Brianne V Boan, Thomas D Lohuis, Kelley M Stewart
Life-history theory is fundamental to understanding how animals allocate resources among survival, development, and reproduction, and among traits within these categories. Immediate trade-offs occur within a short span of time and, therefore, are more easily detected. Trade-offs, however, can also manifest across stages of the life cycle, a phenomenon known as carryover effects. We investigated trade-offs on both time scales in two populations of Dall sheep ( Ovis dalli dalli ) in Southcentral Alaska. Specifically, we (i) tested for glucocorticoid-mediated carryover effects from the breeding season on reproductive success and immune defenses during parturition and (ii) tested for trade-offs between immune defenses and reproduction within a season...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29444816/quality-improvement-effort-to-reduce-hypothermia-among-high-risk-infants-on-a-mother-infant-unit
#14
Christine Andrews, Colleen Whatley, Meaghan Smith, Emily Caron Brayton, Suzanne Simone, Alison Volpe Holmes
BACKGROUND AND OBJECTIVE: Neonatal hypothermia is common in low birth weight (LBW) (<2500 g) and late-preterm infants (LPIs) (34 0/7-36 6/7 weeks' gestation). It can be a contributory factor for newborn admission to a NICU, resulting in maternal-infant separation and increased resource use. Our objective was to study the efficacy of a quality-improvement bundle of hypothermia preventive measures for LPIs and/or LBW infants in a mother-infant unit. METHODS: We conducted plan-do-study-act (PDSA) cycles aimed at decreasing environmental hypothermia for LPIs and/or LBW infants in a mother-infant unit with no other indications for NICU-level care...
February 14, 2018: Pediatrics
https://www.readbyqxmd.com/read/29443924/identification-of-key-pathways-and-genes-in-the-dynamic-progression-of-hcc-based-on-wgcna
#15
Li Yin, Zhihui Cai, Baoan Zhu, Cunshuan Xu
Hepatocellular carcinoma (HCC) is a devastating disease worldwide. Though many efforts have been made to elucidate the process of HCC, its molecular mechanisms of development remain elusive due to its complexity. To explore the stepwise carcinogenic process from pre-neoplastic lesions to the end stage of HCC, we employed weighted gene co-expression network analysis (WGCNA) which has been proved to be an effective method in many diseases to detect co-expressed modules and hub genes using eight pathological stages including normal, cirrhosis without HCC, cirrhosis, low-grade dysplastic, high-grade dysplastic, very early and early, advanced HCC and very advanced HCC...
February 14, 2018: Genes
https://www.readbyqxmd.com/read/29443755/argininemia-as-a-cause-of-severe-chronic-stunting-and-partial-growth-hormone-deficiency-pghd-a-case-report
#16
Xiaotang Cai, Dan Yu, Yongmei Xie, Hui Zhou
RATIONALE: Argininemia is an autosomal recessive inherited disorder of the urea cycle. Because of its atypical symptoms in early age, diagnosis can be delayed until the typical chronic manifestations - including spastic diplegia, deterioration in cognitive function, and epilepsy - appear in later childhood. PATIENT CONCERNS: A Chinese boy initially presented with severe stunting and partial growth hormone deficiency (PGHD) at 3 years old and was initially treated with growth hormone replacement therapy...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443441/cumulative-live-birth-rates-and-perinatal-outcomes-with-the-use-of-time-lapse-imaging-incubators-for-embryo-culture-a-retrospective-cohort-study-of-1882-art-cycles
#17
Mariano Mascarenhas, Sarah J Fox, Karen Thompson, Adam H Balen
OBJECTIVE: Comparison of live birth rates and the perinatal outcomes after fresh and frozen embryo transfer between time lapse imaging (TLI) and standard culture (SC) incubators. DESIGN: Retrospective cohort study. SETTING: A single tertiary level IVF unit. POPULATION: Women undergoing IVF between January 2014 and October 2015. METHODS: Comparison was done between 1064 IVF cycles using TLI (TLI cycles) and 818 IVF cycles using SC (SC cycles)...
February 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29443071/thermal-scanning-conductometry-tsc-as-a-general-method-for-studying-and-controlling-the-phase-behavior-of-conductive-physical-gels
#18
Michal Bielejewski
The thermal scanning conductometry protocol is a new approach in studying ionic gels based on low molecular weight gelators. The method is designed to follow the dynamically changing state of the ionogels, and to deliver more information and details about the subtle change of conductive properties with an increase or decrease in the temperature. Moreover, the method allows the performance of long term (i.e. days, weeks) measurements at a constant temperature to investigate the stability and durability of the system and the aging effects...
January 23, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442673/polypyrrole-nanotube-derived-carbon-aerogels-as-efficient-and-recyclable-oil-absorbents
#19
Jiayou Ji, Xiao Han, Liang Li, Xianghua Yu
Polypyrrole nanotube-derived carbon aerogels with three-dimensional networks have been prepared via freeze-drying and pyrolysis method using polypyrrole nanotubes as precursors. The resulting carbon nanotube aerogels display ultra-low density, fairly high mechanical properties, water repellency, superoleophilicity, high absorption capacity and fast absorption rate of oil and organic solvents. Its absorption capacity can reach in the range from 140 to 600 times of its own weight for the utilized common oil and organic solvents...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439314/effects-of-malat1-on-proliferation-and-apo-ptosis-of-human-non-small-cell-lung-cancer-a549-cells-in-vitro-and-tumor-xenograft-growth-in-vivo-by-modulating-autophagy
#20
Jun Ma, Kaiming Wu, Kuanzhi Liu, Rong Miao
OBJECTIVE: To explore the ability of MALAT1 to influence non-small cell lung cancer (NSCLC) A549 cells in vitro and tumor xenograft growth in vivo by modulating autophagy. METHODS: LncRNA MALAT-1 in normal HBE cells and human NSCLC cells was measured. A549 cells were treated with si-MALAT-1, negative control and si-MALAT-1 + rapamycin. The mRNA levels of MALAT-1, P62 and LC3 was determined by the qRT-PCR and the protein levels of autophagy-related proteins by the western blotting...
January 29, 2018: Cancer Biomarkers: Section A of Disease Markers
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