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Weight cycling

Mehdi Menai, Hélène Charreire, Pilar Galan, Chantal Simon, Julie-Anne Nazare, Camille Perchoux, Christiane Weber, Christophe Enaux, Serge Hercberg, Léopold Fezeu, Jean-Michel Oppert
BACKGROUND: Research on the associations between walking and cycling with obesity-related phenotypes is growing but relies mostly on the use of BMI. The purpose of this study was to analyze associations of walking and cycling behaviors assessed separately with various obesity markers in French adults. METHODS: In 12,776 adult participants (71.3% women) of the on-going NutriNet Santé web-cohort, we assessed by self-report past-month walking and cycling (for commuting, errands and leisure), and obesity measures were taken during a visit at a clinical center (weight, height, waist circumference, and percent body fat by bioimpedance)...
June 22, 2018: Obesity Facts
A Janet Tomiyama
Many pathways connect stress and obesity, two highly prevalent problems facing society today. First, stress interferes with cognitive processes such as executive function and self-regulation. Second, stress can affect behavior by inducing overeating and consumption of foods that are high in calories, fat, or sugar; by decreasing physical activity; and by shortening sleep. Third, stress triggers physiological changes in the hypothalamic-pituitary-adrenal axis, reward processing in the brain, and possibly the gut microbiome...
June 21, 2018: Annual Review of Psychology
Yan Li, Kai Sun, Meng-Yao An, Ying-Ying Pan, Tao Sun, Yong-Qiang Yin, Yi Kang, Jian-Shi Lou
OBJECTIVES: To investigate the effect of taurine magnesium coordination compound (TMCC) on torsades de pointes (TdP) in isolated guinea pig hearts. METHODS: Healthy male guinea pigs weighting 250~300 g were randomly divided into 4 groups:①TdP model group ( n =7):Isolated hearts were perfused by normal K-H solution 20 minutes, then perfused by slowly activated delayed rectifier potassium current(IKs) blocker 10 μ mol/L Chromanol 293B under hypokalemic solution(1...
February 8, 2018: Chinese Journal of Applied Physiology
A M Mahesan, S Sadek, V Moussavi, T Vazifedan, A Majeed, T Cunningham, S Oehninger, S Bocca
PURPOSE: The aims of this study were (1) to evaluate clinical outcomes after ICSI cycles using surgically recovered sperm and (2) to assess the influence of maternal age on those outcomes. METHODS: A retrospective cohort study of 24,763 IVF cycles of fresh autologous oocytes and ICSI using surgically recovered sperm reported to the SART CORS database from 2004 to 2015. RESULTS AND CONCLUSIONS: Older women had significantly longer stimulation (p < 0...
June 20, 2018: Journal of Assisted Reproduction and Genetics
Ruiqi Li, Songbang Ou, Nengyong Ouyang, Lingyan Zheng, Qingxue Zhang, Dongzi Yang, Wenjun Wang
PURPOSE: The objective of this study was to determine whether ammonium accumulates in IVF media during fertility process and whether the brief co-incubation of gametes (bIVF) benefited the outcomes of newborns. METHODS: Ammonium levels in IVF media during gamete co-incubation were measured and the effects of bIVF on neonatal outcomes were evaluated retrospectively in this study. RESULTS: A total of 609 live newborns cycles were included in this study...
June 20, 2018: Journal of Assisted Reproduction and Genetics
Md Maruf Khan, Yoon Seok Choi, Young Kyun Kim, Jin Cheol Yoo
Pectin degrading enzyme has been increasing interest in an industrial application as biocatalysts, such as juice, textile, and wine industry. Bacillus paralicheniformis CBS3, isolated from popular traditional Korean food (kimchi), produced a novel extracellular thermostable alkaline endopolygalacturonase (BPN3). In this study, BPN3 was purified to 22.04-fold with a recovery yield of 18.93% and specific activity of 2216.41 U/mg by gel filtration and anion exchange column chromatography. The molecular mass of BPN3 was approximately 53 kDa as analyzed by SDS-PAGE and pectic zymography...
June 20, 2018: Bioprocess and Biosystems Engineering
Tianyao Zheng, Shulan Su, Xinxin Dai, Liwen Zhang, Jin-Ao Duan, Zhen Ou-Yang
Silkworm excrement (SE), is used as a traditional antirheumatic medicine in China. The present study was designed to investigate the therapeutic efficacy of water fraction of SE (ST) and ethanol fraction of SE (CT) at two different doses on adjuvant induced arthritis (AA) rats. Arthritis severity was evaluated by body weight, paw thickness, histological changes and index of paws oedema and spleen. Serum samples were collected for estimation of biochemical indicators and cytokines. In addition, a metabonomic method based on the ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) had been established to investigate the holistic efficacy of SE by serum and urine...
June 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
P L P Fontes, D D Henry, F M Ciriaco, N Oosthuizen, R F Cooke, V R G Mercadante, N DiLorenzo, G C Lamb
To evaluate the effects of a polyunsaturated fatty acids (PUFA) supplement on reproductive parameters of suckled beef cows, two experiments were conducted. In Experiment (Exp.) 1, 60 primiparous cows were randomly assigned to one of two treatments: CTRL - 1.36 kg/day of corn gluten feed (CGF) and MEGR - 1.36 kg/day of CGF and 0.23 kg/day of calcium salts of soybean oil. Supplementation occurred from 30 days before fixed-time artificial insemination (TAI) until 7 days post-TAI. The expression of interferon-stimulated genes (ISG) was measured on days 18 and 21...
June 21, 2018: Animal: An International Journal of Animal Bioscience
Nathalie Bonvallot, Cécile Canlet, Florence Blas-Y-Estrada, Roselyne Gautier, Marie Tremblay-Franco, Sylvie Chevolleau, Sylvaine Cordier, Jean-Pierre Cravedi
The use of pesticides exposes humans to numerous harmful molecules. Exposure in early-life may be responsible for adverse effects in later life. This study aimed to assess the metabolic modifications induced in pregnant rats and their offspring by a pesticide mixture representative of human exposure. Ten pregnant rats were exposed to a mixture of eight pesticides: acetochlor (246 μg/kg bw/d) + bromoxynil (12 μg/kg bw/d) + carbofuran (22.5 μg/kg bw/d) + chlormequat (35 μg/kg bw/d) + ethephon (22.5 μg/kg bw/d) + fenpropimorph (15...
2018: PloS One
Rugivan Sabaratnam, Andreas J T Pedersen, Jonas M Kristensen, Aase Handberg, Jørgen F P Wojtaszewski, Kurt Højlund
Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-tolerant men before, immediately after and 3-h after acute exercise (60 min cycling) to examine muscle expression and plasma/serum levels of selected myokines...
June 2018: Physiological Reports
Min Kang, Fangfang Wang, Xueyin Liao, Pingting Zhou, Rensheng Wang
The present study is to compare the efficacy and adverse effects of intensity-modulated radiotherapy (IMRT) combined with endostar and IMRT combined with concurrent chemotherapy on locally advanced nasopharyngeal carcinoma (NPC).A total of 23 patients with stage III-IVa NPC were included in the present study, and randomly divided into experimental group (10 cases treated with IMRT + endostar) and control group (13 cases treated with IMRT + chemotherapy of cis-dichlorodiamineplatinum). Endostar was intravenously administered from the first day of IMRT...
June 2018: Medicine (Baltimore)
Fabienne Thomas, Gareth J Veal, Souleiman El Balkhi, Thierry Lafont, Nicolas Picard, Laurence Brugières, Etienne Chatelut, Christophe Piguet
PURPOSE: Chemotherapy dosing in neonates represents a major clinical challenge because of a lack of clinical pharmacology information in this patient population. In this study, we investigate the use of cisplatin dose adaptation based on therapeutic drug monitoring in a 2-week-old neonate with localized hepatoblastoma. METHODS: Cisplatin concentrations were determined in plasma and ultrafiltrate samples collected on each of six cycles of a monotherapy regimen, beginning with a dose of 1...
June 19, 2018: Cancer Chemotherapy and Pharmacology
Xuan Jiang, Xiao Dong, Shi-Hua Li, Yue-Peng Zhou, Simon Rayner, Hui-Min Xia, George F Gao, Hui Yuan, Ya-Ping Tang, Min-Hua Luo
Zika virus (ZIKV) infection is associated with severe neurological defects in fetuses and newborns, such as microcephaly. However, the underlying mechanisms remain to be elucidated. In this study, proteomic analysis on ZIKV-infected primary human fetal neural progenitor cells (NPCs) revealed that virus infection altered levels of cellular proteins involved in NPC proliferation, differentiation and migration. The transcriptional levels of some of the altered targets were also confirmed by qRT-PCR. Among the altered proteins, doublecortin (DCX) plays an important role in NPC differentiation and migration...
2018: Frontiers in Microbiology
Mei-Sa Wang, Yi-Bo Du, Hui-Ming Huang, Zhong-Ling Zhu, Shuang-Shuang Du, Shao-Yong Chen, Hong-Ping Zhao, Zhao Yan
Silkworm cocoon was recorded to cure carbuncle in the Compendium of Materia Medica. Previous studies have demonstrated that the supplemental silk protein sericin exhibits anticancer activity. In the present study, we investigated the effects of silk fibroin peptide (SFP) extracted from silkworm cocoons against human lung cancer cells in vitro and in vivo and its possible anticancer mechanisms. SFP that we prepared had high content of glycine (~ 30%) and showed a molecular weight of ~ 10 kDa. Intragastric administration of SFP (30 g/kg/d) for 14 days did not affect the weights, vital signs, routine blood indices, and blood biochemical parameters in mice...
June 19, 2018: Acta Pharmacologica Sinica
Shunwen Bai, Xinyue Zhao, Dawei Wang, Xuedong Zhang, Nanqi Ren
Environmental impacts of biological wastewater treatment technologies (BWTTs) can be evaluated by life cycle assessment (LCA). However, very few efforts have been made to expand the ranges of results acceptance and promote stakeholders to participate in the results analysis. To facilitate the evaluation reaching more wide and deep understanding, this study proposed to employ multiple weighting methods and the Conjoint Analysis. To investigate the feasibility, an illustrative case of a bioaugmented constructed wetland was carried out...
June 14, 2018: Bioresource Technology
Xiao-Xin Chen, Kar Ho Lam, Yibin Feng, Kai Xu, Stephen C W Sze, Chi Wai Tang, George P H Leung, Calvin Kai-Fai Lee, Jun Shi, Zhijun Yang, Sheng-Tao Li, Zhang-Jin Zhang, Yanbo Zhang
Worldwide, colorectal cancer (CRC) is a deleterious disease causing millions of death annually. 5-Fluorouracil (5-FU) is a first-line chemotherapy for CRC, but chemoresistance and gastrointestinal mucositis limit its efficacy. Polyphenol-rich foods are increasingly popular due to their potential beneficial role in cancer. Ellagitannins is a group of phenolic compounds commonly found in pomegranate, strawberries, raspberries, etc. The objective of this study was to explore whether ellagitannins from pomegranate (PETs) could ameliorate 5-FU-induced intestinal mucositis and enhance its efficacy against CRC...
June 19, 2018: Journal of Agricultural and Food Chemistry
L Li, X Zhang, S-L Hong, Y Chen, G-H Ren
OBJECTIVE: Preeclampsia (PE) is an important disease affecting maternal and neonatal pregnancy. Long non-coding RNA plays an important role in preeclampsia. This study aims to explore the role of HOXA distal transcript antisense RNA (HOTTIP) in preeclampsia. PATIENTS AND METHODS: The expression of HOTTIP in placentas of preeclampsia and normal pregnancy was detected by polymerase chain reaction (PCR). The difference of clinical data between high expression HOTTIP group and low expression HOTTIP group was compared to explore the relationship between HOTTIP and the progress of preeclampsia...
June 2018: European Review for Medical and Pharmacological Sciences
Christian May, Mike Egloff, Andre Butscher, Marius Johann Baptist Keel, This Aebi, Klaus Arno Siebenrock, Johannes Dominik Bastian
BACKGROUND: In elderly patients who have sustained an acetabular fracture involving disruption of the quadrilateral plate (QLP), postoperative loading of the joint beyond the level of partial weight-bearing can result in medial redisplacement of the QLP. The purpose of this biomechanical study was to compare the performances of 4 different fixation constructs intended to prevent medial redisplacement of the QLP. METHODS: Anterior column posterior hemitransverse (ACPHT) fractures with disruption of the QLP were created on synthetic hemipelves (fourth-generation Sawbones models) and subsequently stabilized with (1) a 12-hole plate bridging the QLP (Group 1), (2) the plate with added periarticular screws along the QLP (Group 2), (3) the plate combined with an infrapectineal buttress plate (Group 3), or (4) the plate with the added periarticular screws as well as the buttress plate (Group 4)...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
Kaytee L Pokrzywinski, Thomas G Biel, Elliot T Rosen, Julia L Bonanno, Baikuntha Aryal, Francesca Mascia, Delaram Moshkelani, Steven Mog, V Ashutosh Rao
BACKGROUND: Doxorubicin (DOX), an anthracycline therapeutic, is widely used to treat a variety of cancer types and known to induce cardiomyopathy in a time and dose-dependent manner. Postmenopausal and hypertensive females are two high-risk groups for developing adverse effects following DOX treatment. This may suggest that endogenous reproductive hormones can in part suppress DOX-induced cardiotoxicity. Here, we investigated if the endogenous fluctuations in 17β-estradiol (E2) and progesterone (P4) can in part suppress DOX-induced cardiomyopathy in SST-2 tumor-bearing spontaneously hypersensitive rats (SHRs) and evaluate if exogenous administration of E2 and P4 can suppress DOX-induced cardiotoxicity in tumor-bearing ovariectomized SHRs (ovaSHRs)...
June 15, 2018: Biology of Sex Differences
Michiel J E G W Vanfleteren, Maud Koopman, Martijn A Spruit, Herman-Jan Pennings, Frank Smeenk, Willem Pieters, Jan J A M van den Bergh, Arent-Jan Michels, Emiel F M Wouters, Miriam T J Groenen, Frits M E Franssen, Lowie E G W Vanfleteren
OBJECTIVE: To evaluate the effect of pulmonary rehabilitation (PR) on exercise performance and quality of life in patients with chronic obstructive pulmonary disease (COPD) with different degrees of static lung hyperinflation (LH). DESIGN: Retrospective cohort study. SETTING: Pulmonary Rehabilitation Network. PARTICIPANTS: A cohort of 1981 patients with COPD (55% males; age: 66.8 ± 9.3y; FEV1%: 50.7 ± 19.5; RV%: 163...
June 12, 2018: Archives of Physical Medicine and Rehabilitation
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