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E D Manea, I Stefan, C Olariu, O C Calina, R E Jipa, A Hristea
BACKGROUND: In our country, the national program for hepatitis C virus treatment with ombitasvir/paritaprevir/ritonavir and dasabuvir was approved for patients with stage four of liver fibrosis and stage three associated with specific comorbidities. Our aim was to analyze the characteristics associated with the presence of adverse events in patients receiving this antiviral regimen, with ribavirin in cirrhotic patients. METHODS: We prospectively studied a cohort of adults with hepatitis C virus infection with Child A cirrhosis, treated for 12 weeks with ombitasvir/paritaprevir/ritonavir/dasabuvir and ribavirin, which have been followed in an infectious diseases tertiary-care hospital...
January 2018: Acta Gastro-enterologica Belgica
Joseph E Gaugler, Mark Reese, Mary S Mittelman
Purpose of the Study: A noted limitation of dementia caregiver intervention research is a lack of focus on the mechanisms of successful programs. The purpose of this study was to conduct a process evaluation of the New York University Caregiver Intervention-Adult Child (NYUCI-AC) to describe its delivery and determine which of its components were associated with key outcomes (caregiver stress and well-being; care recipient residential care admission). Design and Methods: Adult child caregivers randomly assigned to receive the NYUCI-AC intervention (n = 54) were included...
March 19, 2018: Gerontologist
Sheena Reilly, Eileen Cini, Lisa Gold, Sharon Goldfeld, James Law, Penny Levickis, Fiona Mensah, Angela Morgan, Jan M Nicholson, Ha N D Le, Angela Pezic, Bruce Tomblin, Melissa Wake, Louise Wardrop
No abstract text is available yet for this article.
March 19, 2018: International Journal of Epidemiology
Kaitlyn Fladeboe, Kyrill Gurtovenko, Madelaine Keim, Joy Kawamura, Kevin M King, Debra L Friedman, Bruce E Compas, David Breiger, Liliana J Lengua, Lynn Fainsilber Katz
Objective:  When a child is diagnosed with cancer, problems may arise in family relationships and negatively affect child adjustment. The current study examined patterns of spillover between marital and parent-child relationships to identify targets for intervention aimed at ameliorating family conflict. Method:  Families (N = 117) were recruited from two US children's hospitals within 2-week postdiagnosis to participate in a short-term prospective longitudinal study...
March 17, 2018: Journal of Pediatric Psychology
Eugene Vortia, Victor E Uko, Belinda Yen-Lieberman, Jill Frawley, Sarah E Worley, Lara Danziger-Isakov, Barbara Kaplan, Lori Mahajan
Background: Tumor necrosis factor alpha (TNF-α) inhibitors are linked with increased risk of reactivation of active tuberculosis. The QuantiFERON-TB Gold In-Tube test is approved for screening latent tuberculosis infection in children and adults. There are limited data on the test performance in children on long-term treatment with TNF-α inhibitors. The objective of this study was to assess the proportion of indeterminate results for the QuantiFERON-TB Gold In-Tube in children with inflammatory bowel disease (IBD) on long-term infliximab treatment and to evaluate the range of interferon-γ responses to mitogen...
March 19, 2018: Inflammatory Bowel Diseases
Kingsley E Agho, Osita K Ezeh, Felix A Ogbo, Anthony I Enoma, Camille Raynes-Greenow
Background: Antenatal care (ANC) is an essential intervention to improve maternal and child health. In Nigeria, no population-based studies have investigated predictors of poor receipt of components and uptake of ANC at the national level to inform targeted maternal health initiatives. This study aimed to examine factors associated with inadequate receipt of components and use of ANC in Nigeria. Methods: The study used information on 20 405 singleton live-born infants of the mothers from the 2013 Nigeria Demographic and Health Survey...
March 19, 2018: International Health
Erika L Rangel, Douglas S Smink, Manuel Castillo-Angeles, Gifty Kwakye, Marguerite Changala, Adil H Haider, Gerard M Doherty
Importance: Although family priorities influence specialty selection and resident attrition, few studies describe resident perspectives on pregnancy during surgical training. Objective: To directly assess the resident experience of childbearing during training. Design, Setting, and Participants: A self-administered 74-question survey was electronically distributed in January 2017 to members of the Association of Women Surgeons, to members of the Association of Program Directors in Surgery listserv, and through targeted social media platforms...
March 21, 2018: JAMA Surgery
Firley Poliana da Silva Lúcio, Paula Daniella de Abreu, Eliane Maria Ribeiro de Vasconcelos, Ednaldo Cavalcante de Araújo
OBJECTIVE: To evaluate the social network of lesbian mothers, from the social contexts of support or restraint. METHOD: Descriptive, exploratory study, of qualitative approach, based on the theoretical reference of Social Network, with eight lesbian mothers selected through Snowball technique, using semi-structured interview. Data analysis was performed with IRAMUTEQ software, through Similarity Analysis. RESULTS: The social network is configured as: 1) Emotional distance and non-acceptance of motherhood by the family members - primary network elements; 2) Interference in the socio-cultural medium for the effectiveness of the mother-child bond - secondary network elements...
2018: Revista Brasileira de Enfermagem
Illce B Lázaro-Pacheco, Alfredo I Servín-Caamaño, José L Pérez-Hernández, Gabriela Rojas-Loureiro, Luis Servín-Abad, Fátima Higuera-DE LA Tijera
BACKGROUND: Acid suppression has been associated with adverse events; such as, enteric infections. Proton pump inhibitors (PPI) are frequently prescribed in patients with cirrhosis, but is unclear if PPI are associated with the development of bacterial infections in these patients. OBJECTIVE: To assess the impact of PPI intake on the development of bacterial, viral and fungal infections in patients with cirrhosis. METHODS: An observational, retrospective, historic cohort study...
January 2018: Arquivos de Gastroenterologia
Daniel Souza Lima, Abdon José Murad Júnior, Márcio Alencar Barreira, Guilherme Cardoso Fernandes, Gustavo Rego Coelho, José Huygens Parente Garcia
BACKGROUND: The Amazon region is one of the main endemic areas of hepatitis delta in the world and the only one related to the presence of genotype 3 of the delta virus. OBJECTIVE: To analyze the profile, mortality and survival of cirrhotic patients submitted to liver transplantation for chronic hepatitis delta virus and compare with those transplanted by hepatitis B virus monoinfection. METHODS: Retrospective, observational and descriptive study...
January 2018: Arquivos de Gastroenterologia
Elia Psouni, Raquel Perez Vicente, Lars B Dahlin, Juan Merlo
Chronic handicap in early life may have a long-term impact on children's psychosocial well-being. Here, we investigated whether Brachialis Plexus Birth Injury (BPBI)-an unpredictable injury at birth-is associated with worse mental health later on, as indicated by prescription and use of psychotropic drugs in adolescence. We explored further whether this association is different depending on socioeconomic characteristics of the child's family, as well as sex. Of the 641 151 children born to native parents in Sweden 1987-1993 (alive and still living in Sweden at the end of 2008), identified in the Swedish Medical Birth Registry, 1587 had suffered a BPBI...
2018: PloS One
Mekonen Eshete Abebe, Wakgari Deressa, Victoria Oladugba, Arwa Owais, Taye Hailu, Fikre Abate, Abiye Hailu, Yohannes Demissie, Shiferaw Degu, Bezuwork Alemayehu, Mulualem Gessesse, Milliard Deribew, Paul Egl Gravem, Peter Mossey, Azeez Butali
OBJECTIVE: To assess the oral health-related quality of life (OH-RQoL) using a translated standardized measure in an understudied population of Ethiopian children born with orofacial clefts (OFCs) and their parents. METHODS: Using a descriptive study design, we assessed the OH-RQoL of 41 patients with OFCs between the ages of 8 and 17 years and their parents. Participants received multidisciplinary cleft care from 2008 to 2016. They completed an Amharic translation of the Child Oral Health Impact Profile (COHIP)...
January 1, 2018: Cleft Palate-craniofacial Journal
Wies Maarse, Chantal W B Boonacker, Henriette F N Swanenburg de Veye, Moshe Kon, Corstiaan C Breugem, Aebele B Mink van der Molen, Johannes J M van Delden
OBJECTIVES: The prenatal diagnosis of oral clefts (OCs) by ultrasound can pose an ethical dilemma. The purpose of this study was to obtain insight into the psychosocial and moral considerations of prospective parents concerning OCs, the burden of OCs and parents' attitude toward possible termination of pregnancy (TOP) in order to improve counseling in the future. DESIGN: Between August 2011 and August 2014, a prospective cohort questionnaire study was administered...
January 1, 2018: Cleft Palate-craniofacial Journal
Kieran S O'Brien, Sun Y Cotter, Abdou Amza, Boubacar Kadri, Beido Nassirou, Nicole E Stoller, Zhaoxia Zhou, Sheila K West, Robin L Bailey, Jeremy D Keenan, Travis C Porco, Thomas M Lietman
BACKGROUND: Mass distributions of azithromycin for trachoma have been associated with secondary benefits, including reductions in child mortality. METHODS: In the PRET cluster-randomized trial for trachoma in Niger, 24 communities were randomized to annual treatment of everyone and 24 communities were randomized to biannual treatment of children under 12 for 3 years (, NCT00792922). Treatment was a single dose of directly observed oral azithromycin (20mg/kg up to 1gm in adults)...
March 14, 2018: Pediatric Infectious Disease Journal
Saghar Safamanesh, Amir Azimian, Abdolreza Shakeri, Kiarash Ghazvini, Saeid Amel Jamehdar, Mahsa Khosrojerdi, Masoud Youssefi
Porcine bocavirus (PBoV) is a recently discovered virus classified within the Bocavirus genus. We present a case of upper respiratory tract infection associated with PBoV in a three-year-old child who was in close contact with hogs in northeastern Iran. To the best of our knowledge, this is the first report on the human PBoV infection. Upcoming reports from different regions of the world could provide a generalized view of the spread of pig-to-human transmission of the virus.
March 15, 2018: Pediatric Infectious Disease Journal
Krystal L Schulle, David A Berntsen, Loraine T Sinnott, Katherine M Bickle, Anita T Gostovic, Gilbert E Pierce, Lisa A Jones-Jordan, Donald O Mutti, Jeffrey J Walline
SIGNIFICANCE: Practitioners fitting contact lenses for myopia control frequently question whether a myopic child can achieve good vision with a high-add multifocal. We demonstrate that visual acuity is not different than spectacles with a commercially available, center-distance soft multifocal contact lens (MFCL) (Biofinity Multifocal "D"; +2.50 D add). PURPOSE: To determine the spherical over-refraction (SOR) necessary to obtain best-corrected visual acuity (BCVA) when fitting myopic children with a center-distance soft MFCL...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
William Abouhassan, John Kuang Chao, Ananth S Murthy
BACKGROUND: Craniosynostosis is an uncommon complication after shunting procedures for congenital hydrocephalus. We report a case of a child with myelomeningocele and normocephaly at the time of birth. She underwent ventricular shunting for Chiari malformation and hydrocephalus at 3 days of age. An immediate postoperative CT scan confirmed all sutures were open. Serial CT scans document an open metopic suture at 2 months, closed metopic suture at 5 months, and trigonocephaly at 11 months with concomitant slit ventricle syndrome, and collapsed lateral and third ventricles...
March 20, 2018: Journal of Craniofacial Surgery
Hong-Mei Luo, Shu-Zhen Zhao, Chuan Li, Li-Ping Chen
Minimal information is available concerning platelet-albumin-bilirubin (PALBI) grades in patients with hepatocellular carcinoma (HCC) following liver resection. This study aimed to investigate the predictive ability of PALBI grades in patients with a Child-Pugh class A score and hepatitis B virus-related (HBV-related) HCC after liver resection.The data of patients with HBV-related HCC who underwent liver resection from 2010 to 2017 at our center were reviewed (n = 785). Cox regression was used to determine factors independently associated with postoperative recurrence and mortality...
March 2018: Medicine (Baltimore)
Yan Tan, Yunming Li, Juan Wu, Fuqin Chen, Hao Lu, Shijun Lu, Xianjun Yang, Xiao Ma
This study investigated the mental health of military transport personnel in the Western Sichuan Plateau of China, and factors that correlate with their mental health.The Symptom Checklist 90 (SCL-90) was used to investigate the mental health status of the subjects. Their scores were compared with the national and military norm in China. Demographic factors were analyzed for associations with SCL-90 scores.Psychological problems were detected in 28.90% of total 1076 male officers and soldiers surveyed. The SCL-90 scale somatization score of these servicemen was higher than the national and military norms in China, while other scores were comparable...
March 2018: Medicine (Baltimore)
Dan Lu, Jun Liu, Yuan Chen, Fei Chen, Hui Yang
RATIONALE: Ganglioneuroblastoma is usually located in the adrenal gland, retroperitoneal ganglia, or posterior mediastinum, but rarely occurs in the parapharyngeal space. PATIENT CONCERNS: A 4-year-old girl presented with complaint of progressive inspiratory dyspnea and dysphagia, accompanying left-side Horner's syndrome. DIAGNOSE: Computed tomography (CT) scan revealed a giant mass with irregular low density in left oropharyngeal and posterior pharyngeal wall...
March 2018: Medicine (Baltimore)
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