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https://www.readbyqxmd.com/read/28087963/vitamin-d-deficiency-rickets-even-with-abundant-sunlight-a-case-to-highlight-emerging-problem
#1
T H Ting, A S Devnani
We describe a case of vitamin-D-deficiency rickets in a young child to highlight its existence in Malaysia where sunlight is abundant throughout the year. The child presented with deformity of both legs. He came from an educated urban family but remained indoors most of the time. Radiographs of knees and wrists showed changes of florid rickets. Low serum 25-hydoxyvitamin-D, high parathyroid hormone, normal serum phosphate and calcium levels, and normal renal function clinched the diagnosis of vitamin-D-deficiency rickets...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28087725/neurodevelopmental-outcomes-of-extremely-low-birthweight-infants-randomised-to-different-pco2-targets-the-phelbi-follow-up-study
#2
Ulrich H Thome, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Annett Bläser, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Maria Zernickel, Harald Bode, Jens Dreyhaupt, Rainer Muche, Helmut D Hummler
BACKGROUND: Tolerating higher partial pressures of carbon dioxide (PCO2) in mechanically ventilated extremely low birthweight infants to reduce ventilator-induced lung injury may have long-term neurodevelopmental side effects. This study analyses the results of neurodevelopmental follow-up of infants enrolled in a randomised multicentre trial. METHODS: Infants (n=359) between 400 and 1000 g birth weight and 23 0/7-28 6/7 weeks gestational age who required endotracheal intubation and mechanical ventilation within 24 hours of birth were randomly assigned to high PCO2 or to a control group with mildly elevated PCO2 targets...
January 13, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28087543/leisure-time-sport-and-overuse-injuries-of-extremities-in-children-age-6-13-a-2-5%C3%A2-years-prospective-cohort-study-the-champs-study-dk
#3
Charlène Chéron, Charlotte Leboeuf-Yde, Christine Le Scanff, Eva Jespersen, Christina Trifonov Rexen, Claudia Franz, Niels Wedderkopp
OBJECTIVES: It is not known which sports are most likely to cause overuse injuries of the extremities in children. In this study, we report on the incidence of overuse injuries of the upper and lower extremities in children who participate in various leisure-time sports and relate this to the frequency of sport sessions. DESIGN: Natural experiment including a prospective cohort study. SETTING: 10 state schools in 1 Danish municipality: Svendborg...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28087478/renal-involvement-in-lysinuric-protein-intolerance-contribution-of-pathology-to-assessment-of-heterogeneity-of-renal-lesions
#4
Emmanuel Estève, Pauline Krug, Aurélie Hummel, Jean-Baptiste Arnoux, Olivia Boyer, Anais Brassier, Pascale de Lonlay, Vincent Vuiblet, Stéphanie Gobin, Rémi Salomon, Christine Piètrement, Jean-Paul Bonnefont, Aude Servais, Louise Galmiche
Lysinuric protein intolerance (LPI) is a rare autosomal recessive disease caused by mutations in the SLC7A7 gene encoding the light subunit of a cationic amino acid transporter. Symptoms mimic primary urea cycle defects but dysimmune symptoms are also described. Renal involvement in LPI was first described in the 1980's. In 2007, it appeared that it could concern as much as 75% of LPI patients and could lead to end stage renal disease. The most common feature is proximal tubular dysfunction and nephrocalcinosis but glomerular lesions are also reported...
January 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28087346/patterns-of-retinal-hemorrhage-associated-with-pediatric-cerebral-sinovenous-thrombosis
#5
Gil Binenbaum, Julia E Reid, David L Rogers, Anne Jensen, Lori L Billinghurst, Brian J Forbes
BACKGROUND: Cerebral sinovenous thrombosis (CSVT) has been proposed as an alternative cause of retinal hemorrhage (RH) in children being evaluated for abusive head trauma. This study investigated the prevalence and characteristics of RH in children with CSVT. METHODS: The medical records of children >6 weeks of age with newly diagnosed CSVT and fundus examination by an ophthalmologist were examined retrospectively. Primary outcomes were presence and patterns of RH...
January 10, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28087208/-child-langerhans-cell-histiocytosis
#6
Jean Donadieu, Sébastien Héritier
DEFINITION: Langerhans cell histiocytosis (LCH) is defined by the association of a clinical and radiological involvement and a biopsy of a pathological tissue. Extension: it can affect any organ or system of the body but most commonly the bone (80% of cases), the skin (33%) and the pituitary (25%). Other organs are concerned such as liver, spleen, hematopoietic system and the lungs (15% each), lymph nodes (5-10%) and central nervous system (CNS) excluding the pituitary (2-4%). Natural history: the natural history of the disease is very heterogeneous, ranging from auto-regressive lesions to a disease affecting multiple organs with fatal consequences, while some lesions may be responsible for permanent sequels...
January 10, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28087202/family-adaptation-to-cerebral-palsy-in-adolescents-a-european-multicenter-study
#7
Audrey Guyard, Susan I Michelsen, Catherine Arnaud, Jerome Fauconnier
BACKGROUND AND AIM: Factors promoting family adaptation to child's disability are poorly studied together. The aim of the study was to describe the family adaptation to disability and to identify determinants associated with using a global theoretical model. MATERIALS AND METHODS: 286 families of teenagers [13-17 years] with cerebral palsy (CP) from 4 European disability registers were included and visited at home. Face to face interviews were performed in order to measure parental distress, perceived impact in various dimensions of family life, family resources and stressors...
January 10, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28087088/discharge-teaching-readiness-for-discharge-and-post-discharge-outcomes-in-parents-of-hospitalized-children
#8
Marianne E Weiss, Kathleen J Sawin, Karen Gralton, Norah Johnson, Carol Klingbeil, Stacee Lerret, Shelly Malin, Olga Yakusheva, Rachel Schiffman
PURPOSE: This study explored the sequential relationships of parent perceptions of the quality of their discharge teaching and nurse and parent perceptions of discharge readiness to post-discharge outcomes (parental post-discharge coping difficulty, readmission and emergency department visits). DESIGN/METHODS: In this secondary analysis of data from a longitudinal pilot study of family self-management discharge preparation, the correlational design used regression modeling with data from a convenience sample of 194 parents from two clinical units at a Midwest pediatric hospital...
January 10, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28086975/a-qualitative-study-of-women-s-and-health-providers-attitudes-and-acceptability-of-mistreatment-during-childbirth-in-health-facilities-in-guinea
#9
Mamadou Diouldé Balde, Abou Bangoura, Boubacar Alpha Diallo, Oumar Sall, Habibata Balde, Aïssatou Sona Niakate, Joshua P Vogel, Meghan A Bohren
BACKGROUND: Reducing maternal morbidity and mortality remains a key health challenge in Guinea. Anecdotal evidence suggests that women in Guinea are subjected to mistreatment during childbirth in health facilities, but limited research exists on this topic. This study was conducted to better understand the social norms and the acceptability of four scenarios of mistreatment during childbirth, from the perspectives of women and service providers. METHODS: This study used qualitative methods including in-depth interviews (IDIs) and focus group discussions (FGDs) with women of reproductive age, midwives, nurses and doctors...
January 13, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28086945/complete-deltoid-resection-in-early-childhood-without-muscle-transfer-results-in-normal-shoulder-function-at-long-term-follow-up-a-case-report
#10
Annie Arteau, Franziska Seeli, Bruno Fuchs
BACKGROUND: Musculoskeletal tumors involving the deltoid muscle and necessitating its complete resection are rare. The function after complete deltoid resection is reported to be limited, and several authors consider muscle transfer to improve shoulder motion. However, it still remains unclear whether such transfer adds function. To the best of our knowledge, all reports on complete deltoid resection refer to adult patients, and it is unknown what function results after deltoid resection in childhood...
January 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28086942/external-beam-radiotherapy-for-unresectable-hepatocellular-carcinoma-an-international-multicenter-phase-i-trial-sakk-77-07-and-sasl-26
#11
Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour, Daniel M Aebersold
PURPOSE: To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC). METHODS: Patients with histologically confirmed stage cT1-4, cN0-1 HCC and Child-Pugh Score (CPS) A or B disease were included in a phase I multicenter trial. Metastatic HCC were allowed if ≥90% of total tumor volume was located within the liver. Patients were enrolled onto five dose-escalation levels (54-70Gy in 2Gy fractions) based on a modified 3 + 3 design, with cohorts of five patients instead of three patients in dose levels 4 and 5...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28086835/stunting-and-severe-stunting-among-children-under-5%C3%A2-years-in-nigeria-a-multilevel-analysis
#12
Blessing Jaka Akombi, Kingsley Emwinyore Agho, John Joseph Hall, Dafna Merom, Thomas Astell-Burt, Andre M N Renzaho
BACKGROUND: Stunting has been identified as one of the major proximal risk factors for poor physical and mental development of children under-5 years. Stunting predominantly occurs in the first 1000 days of life (0-23 months) and continues to the age of five. This study examines factors associated with stunting and severe stunting among children under-5 years in Nigeria. METHODS: The sample included 24,529 children aged 0-59 months from the 2013 Nigeria Demographic and Health Survey (NDHS)...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28081590/emergency-endoscopic-variceal-ligation-in-cirrhotic-patients-with-blood-clots-in-the-stomach-but-no-active-bleeding-or-stigmata-increases-the-risk-of-rebleeding
#13
Su Jin Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Young Mi Hong, Ki Tae Yoon, Mong Cho, Hyung Seok Nam, Sm Bakhtiar Ui Islam
BACKGROUND/AIMS: This study aimed to evaluate the efficacy and safety of emergency variceal ligation for the prevention of rebleeding in cirrhotic patients who are found on initial endoscopy to have blood clots in the stomach but no actively bleeding esophageal and gastric varices or stigmata. METHODS: This study included 28 cirrhotic patients who underwent emergency prophylactic EVL and 41 who underwent an elective intervention between January 2009 and June 2014...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28081589/preemptive-antiviral-therapy-with-entecavir-can-reduce-acute-deterioration-of-hepatic-function-following-transarterial-chemoembolization
#14
Sun Hong Yoo, Jeong Won Jang, Jung Hyun Kwon, Seung Min Jung, Bohyun Jang, Jong Young Choi
BACKGROUND/AIMS: Hepatic damage during transarterial chemoembolization (TACE) is a critical complication in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Apart from its role in preventing HBV reactivation, there is some evidence for the benefits of preemptive antiviral therapy in TACE. This study evaluated the effect of preemptive antiviral therapy on acute hepatic deterioration following TACE. METHODS: This retrospective observational study included a prospectively collected cohort of 108 patients with HBV-related HCC who underwent TACE between January 2007 and January 2013...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28081587/clinical-significance-and-predictive-factors-of-early-massive-recurrence-after-radiofrequency-ablation-in-patients-with-a-single-small-hepatocellular-carcinoma
#15
Ju-Yeon Cho, Moon Seok Choi, Gil Sun Lee, Won Sohn, Jemma Ahn, Dong-Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
BACKGROUND/AIMS: Radiofrequency ablation (RFA) is one of the most frequently applied curative treatments in patients with a single small hepatocellular carcinoma (HCC). However, the clinical significance of and risk factors for early massive recurrence after RFA-a dreadful event limiting further curative treatment-have not been fully evaluated. METHODS: In total, 438 patients with a single HCC of size ≤3 cm who underwent percutaneous RFA as an initial treatment between 2006 and 2009 were included...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28081517/a-path-analysis-model-of-factors-influencing-children-s-requests-for-unhealthy-foods
#16
Simone Pettigrew, Michelle Jongenelis, Caroline Miller, Kathy Chapman
Little is known about the complex combination of factors influencing the extent to which children request unhealthy foods from their parents. The aim of this study was to develop a comprehensive model of influencing factors to provide insight into potential methods of reducing these requests. A web panel provider was used to administer a national online survey to a sample of 1302 Australian parent-child dyads (total sample n=2604). Initial univariate analyses identified potential predictors of children's requests for and consumption of unhealthy foods...
December 27, 2016: Eating Behaviors
https://www.readbyqxmd.com/read/28081496/the-role-of-negative-parental-attributions-in-the-associations-between-daily-stressors-maltreatment-history-and-harsh-and-abusive-discipline
#17
Marieke Beckerman, Sheila R van Berkel, Judi Mesman, Lenneke R A Alink
Negative parental attributions are related to parent and family stressors and are thought to be important predictors of subsequent disciplinary actions and, potentially, abusive parenting. We examined if negative parental attributions mediate the relation between daily stressors (i.e., low SES, parenting stress, partner-related stress) parents' own history of child maltreatment, and harsh and abusive parenting. Mothers (n=53) completed a computerized attribution task and reported on daily stressors, their own history of child maltreatment and their discipline strategies...
January 9, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28081049/the-first-infant-death-associated-with-human-coronavirus-nl63-infection
#18
Capan Konca, Gulay Korukluoglu, Mehmet Tekin, Habip Almis, İbrahim Hakan Bucak, Hatice Uygun, Ayse Basak Altas, Fatma Bayrakdar
Human coronavirus NL63 (HCoV-NL63) primarily infects the upper respiratory tract. However, it may cause severe lower respiratory tract infection, and the clinical course may be severe in immunocompromised patients. To our knowledge, child death due to HCoV-NL63 has not been reported. We present a fatal lower respiratory tract disease associated with HCoV-NL63 in a 7-month-old malnourished infant.
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28080325/adequacy-of-parent-packed-lunches-and-preschooler-s-consumption-compared-to-dietary-reference-intake-recommendations
#19
Maria Jose Romo-Palafox, Nalini Ranjit, Sara J Sweitzer, Cindy Roberts-Gray, Courtney E Byrd-Williams, Margaret E Briley, Deanna M Hoelscher
BACKGROUND: U.S. preschool children consume inadequate amounts of key nutrients. Understanding the contents of lunches packed by parents and consumed by their children can help identify areas of opportunity for the development of healthy food preferences. OBJECTIVE: To evaluate the nutrient adequacy of lunches packed by parents and consumed by children attending early care and education (ECE) centers. METHODS: Baseline data from 607 parent-child dyads in the "Lunch Is in the Bag" cluster-randomized controlled trial in Central Texas were examined...
January 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28080108/the-brief-problem-monitor-parent-form-bpm-p-a-short-version-of-the-child-behavior-checklist-psychometric-properties-in-spanish-6-to-8-year-old-children
#20
Eva Penelo, Núria de la Osa, José Blas Navarro, Josep Maria Domènech, Lourdes Ezpeleta
We provide the first validation data on the Spanish version of the Brief Problem Monitor-Parent form (BPM-P), a recently developed abbreviated version of the 120-item Child Behavior Checklist for Ages 6 to 18 (CBCL/6-18) in young schoolchildren. Parents of a community sample of 521 children aged 6-8 answered the CBCL/6-18 yearly, and the 19 BPM-P items were examined; parents also provided different measures of psychopathology. Confirmatory factor analysis of the expected 3-factor model (attention, externalizing, and internalizing) showed adequate fit (root mean square error of approximation, RMSEA ≤ ...
January 12, 2017: Psychological Assessment
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