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https://www.readbyqxmd.com/read/29668136/-a-fatal-case-series-of-rocky-mountain-spotted-fever-in-sonora-m%C3%A3-xico
#1
Jesús Delgado-De la Mora, Jesús David Licona-Enríquez, Marcia Leyva-Gastélum, David Delgado-De la Mora, Adela Rascón-Alcantar, Gerardo Álvarez-Hernández
INTRODUCTION: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly. OBJECTIVE: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México. MATERIALS AND METHODS: We conducted a cross-sectional study on a series of 47 deaths caused by Rickettsia rickettsii from 2013 to 2016. The diagnosis of Rocky Mountain spotted fever was confirmed in a single blood sample by polymerase chain reaction (PCR) or by a four-fold increase in immunoglobulin G measured in paired samples analyzed by indirect immunofluorescence...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668117/development-of-molecular-therapies-for-venous-malformations
#2
Jaakko Kangas, Marjut Nätynki, Lauri Eklund
Vascular anomalies are localized defects of morphogenesis that can affect lymphatic and blood vessels. They are generally called birthmarks, typically observed soon after birth and occurring in up to 10% of children. Based on their clinical and histological characteristics, they are classified into vascular tumours and vascular malformations. The most common malformations are venous malformations (VMs) resulting in chronic vascular diseases that can be associated with significant morbidity necessitating often demanding and repeating clinical management...
April 18, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29668076/comparative-analyses-of-the-gut-microbiota-among-three-different-wild-geese-species-in-the-genus-anser
#3
Wen Wang, Yingbao Liu, Yongsheng Yang, Aizhen Wang, Kirill Sharshov, Yao Li, Mengyao Cao, Puzhen Mao, Laixing Li
In this study, we characterized for the first time the gut microbiota of Greylag geese (Anser anser) using high-throughput 16S rRNA gene sequencing technology. The results showed that the phyla Firmicutes (78.55%), Fusobacteria (9.38%), Proteobacteria (7.55%), Bacteroidetes (1.82%), Cyanobacteria (1.44%), and Actinobacteria (0.61%) dominated the gut microbial communities in the Greylag geese. Then, the variations of gut microbial community structures and functions among the three geese species, Greylag geese, Bar-headed geese (Anser indicus), and Swan geese (Anser cygnoides), were explored...
April 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29668045/when-does-the-influence-of-maturation-on-anthropometric-and-physical-fitness-characteristics-increase-and-subside
#4
Christopher Towlson, Stephen Cobley, Guy Parkin, Ric Lovell
The relationships between maturation and anthropometric and physical performance characteristics are dynamic and often asynchronous; confounding the capability to accurately evaluate performance during adolescence. This study aimed to (i) examine the influence of chronological age (CA) and somatic maturation (YPHV) upon anthropometric and physical performance parameters, and (ii) identify the transition/change time-points in these relationships using segmental regression. N=969 soccer players (8-18 years of age) completed anthropometric and physical test assessments, including a counter-movement jump (CMJ), agility T-test, 10 and 20m sprints, and multi-stage fitness test (MSFT)...
April 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29668037/treatment-of-chronic-neurogenic-cough-with-in-office-superior-laryngeal-nerve-block
#5
C Blake Simpson, Kathleen M Tibbetts, Michael J Loochtan, Laura M Dominguez
OBJECTIVES: Neurogenic cough is believed to result from a sensory neuropathy involving the internal branch of the superior laryngeal nerve (SLN). We present our outcomes for the treatment of neurogenic cough with localized blockade of the internal branch of the SLN. METHODS: A retrospective chart review of patients who underwent in-office percutaneous SLN block for treatment of neurogenic cough between 2015 and 2017 was conducted. Patient demographics, indications for injection, and response to treatment were recorded and analyzed...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668002/a-sharp-edge-based-acoustofluidic-chemical-signal-generator
#6
Po-Hsun Huang, Chung Yu Chan, Peng Li, Yuqi Wang, Nitesh Nama, Hunter Bachman, Tony Jun Huang
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these signaling pathways requires the exposure of cells to time-varying chemical signals; these are difficult to generate and control over a wide temporal range. Herein, we present an acoustofluidic chemical signal generator based on a sharp-edge-based micromixing strategy. The device, simply by modulating the driving signals of an acoustic transducer including the ON/OFF switching frequency, actuation time and duty cycle, is capable of generating both single-pulse and periodic chemical signals that are temporally controllable in terms of stimulation period, stimulation duration and duty cycle...
April 18, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29667943/factors-associated-with-initiation-of-biologics-in-patients-with-axial-spondyloarthritis-in-an-urban-asian-city-a-prespond-study
#7
Wan Yu Png, Yu Heng Kwan, Yi Xuan Lee, Ka Keat Lim, Eng Hui Chew, Nai Lee Lui, Chuen Seng Tan, Julian Thumboo, Truls Østbye, Warren Fong
OBJECTIVE: The aim of this study was to examine if patients' sociodemographic, clinical characteristics, and patient-reported outcomes were associated with biologics initiation in patients with axial spondyloarthritis in Singapore. METHODS: Data from a dedicated registry from a tertiary referral center in Singapore from January 2011 to July 2016 were used. Initiation of first biologics was the main outcome of interest. Logistic regression analyses were used to explore the association of various factors on biologics initiation...
April 5, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29667902/myocardial-protection-following-del-nido-cardioplegia-in-pediatric-cardiac-surgery
#8
Debasish Panigrahi, Saibal Roychowdhury, Rahul Guhabiswas, Emmanuel Rupert, Mrinalendu Das, Pradeep Narayan
Background This study was designed to compare myocardial protection with del Nido cardioplegia and conventional blood cardioplegia in children undergoing cardiac surgery in Risk Adjustment for Congenital Heart Surgery categories 1 and 2. Methods Sixty patients were randomized into 2 groups receiving del Nido cardioplegia solution or conventional blood cardioplegia. Myocardial injury was assessed using biochemical markers (troponin I and creatine kinase-MB). Vasoactive-inotropic scores were calculated to compare inotropic requirements...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29667881/the-ability-of-adc-measurements-in-the-assessment-of-patients-with-stage-i-endometrial-carcinoma-based-on-three-risk-categories
#9
Shijia Wang, Jia Liu, Feng Yuan, Xiaojun Chen, Fenghua Ma, Guofu Zhang, Xiaomei Tian
Background Better selection of patients with intermediate and high-risk stage I endometrial carcinoma (EC) for lymphadenectomy has an important effect on the prognosis. Purpose To investigate the role of apparent diffusion coefficient (ADC) measurements in the assessment of stage I EC patients based on three risk categories. Material and Methods We retrospectively studied 80 patients with EC and 28 cervical cancer patients with normal endometrium. 1.5-T conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) (b = 0, 1000 s/mm2 ) were performed, and ADC values were calculated...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667857/determining-risk-factors-that-increase-hospitalizations-in-patients-with-systemic-lupus-erythematosus
#10
D Li, H M Madhoun, W N Roberts, W Jarjour
Introduction Systemic lupus erythematosus (SLE) is a complex disease that is associated with significant mortality and an increased risk of hospitalization. Several validated instruments are available to measure disease activity in SLE patients. However, these instruments were not designed to screen for SLE patients at an increased risk of hospitalization. These instruments also fail to incorporate some data that are easily obtainable from electronic health records, such as the frequency of missed outpatient appointments...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29667768/quinazoline-based-hydroxamic-acids-design-synthesis-and-evaluation-of-histone-deacetylase-inhibitory-effects-and-cytotoxicity
#11
Doan Thanh Hieu, Duong Tien Anh, Hai Pham-The, Le-Thi-Thu Huong, Eun Jae Park, Jeong Eun Choi, Jong Soon Kang, Sang-Bae Han, Phan Thi Phuong Dung, Nguyen-Hai Nam
In our search for novel histone deacetylases inhibitors, we have designed and synthesized a series of novel hydroxamic acids and N-hydroxybenzamides incorporating quinazoline heterocycles (4a-i, 6a-i). Bioevaluation showed that these quinazoline-based hydroxamic acids and N-hydroxybenzamides were potently cytotoxic against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung). In term of cytotoxicity, several compounds, e.g. 4g, 4c, 4g-i, 6c, and 6h, displayed from 5- up to 10-fold higher potency than SAHA (suberoylanilidehydroxamic acid, vorinostat)...
April 18, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29667727/stimuli-responsive-peptide-gels-and-some-bio-applications
#12
Natashya Falcone, Heinz-Bernhard Kraatz
Supramolecular gels are a fascinating class of soft materials that have attracted significant attention in recent years. They are composed of small molecule gelators that assemble into supramolecular network structures. The resulting space is filled with solvent. Some gel materials are able to respond to various stimuli making them attractive drug delivery vehicles and as matrices for tissue regeneration. Peptide based gel materials are particularly attractive as they possess numerous advantages including biocompatibility and biodegradability...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29667669/structural-characterization-and-antitumor-activity-of-a-novel-se-polysaccharide-from-selenium-enriched-cordyceps-gunnii
#13
Huiqing Sun, Zhenyuan Zhu, Yali Tang, Yuanyuan Ren, Qiaoying Song, Yun Tang, Yongmin Zhang
Selenium (Se) has been recognized as an essential element. Animals and humans absorb and retain more organic Se than inorganic Se. Bio-transformation is a major approach to transform inorganic Se to organic Se. Cordyceps gunnii (C. gunnii), well known as a Chinese edible and medicinal fungus, has a variety of biological functions. C. gunnii and selenium were combined through liquid-fermentation to obtain selenium-enriched C. gunnii. A novel Se-polysaccharide (SeCPS-II) was extracted from selenium-enriched C...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29667666/a-luminescent-benzothiadiazole-bridging-bis-salicylaldiminato-zinc-ii-complex-with-mechanochromic-and-organogelation-properties
#14
Xiaoxian Song, Hanbo Yu, Xianju Yan, Yuewei Zhang, Yang Miao, Kaiqi Ye, Yue Wang
Herein, a new bis(salicylaldiminato)Zn(ii) Schiff base complex, BTZn, derived from benzo[c][1,2,5]thiadiazole-5,6-diamine was designed and synthesized. It exhibited unique mechanical force-induced luminescence change characteristic. Upon mechanical grinding, the as-prepared BTZn solid crystalized from an ethanol/dichloromethane solution displays a high-contrast emission-colour variation from yellow (emission maximum λem = 545 nm) to red (λem = 645 nm), and this emission variation can be erased through solvent vapour treatment...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667646/leptospirosis-and-workplace-environmental-risk-factors-among-cattle-farmers-in-northeastern-malaysia
#15
Aziah Binti Daud, Nik Mohd Hafiz Mohd Fuzi, Wan Mohd Zahiruddin Wan Mohammad, Fairuz Amran, Nabilah Ismail, Mohd Mokhtar Arshad, Suratan Kamarudin
BACKGROUND: Leptospirosis is an emerging zoonosis and its occurrence has been reported to be rising globally. The environment plays an important role in the survival of Leptospira and determines the risk of infection. Those who were exposed to and had contact with contaminated environment through their occupational, recreational and other activities can be infected with the organism. OBJECTIVE: To determine the seroprevalence of leptospirosis among cattle farmers, prevalence of pathogenic Leptospira, and the workplace environmental risk factors for leptospirosis among cattle farmers in northeastern Malaysia...
April 2018: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29667637/-the-expert-characteristic-of-the-forensic-medical-documentation-for-the-purpose-of-investigations-of-the-injuries-to-the-maxillofacial-region
#16
V L Popov, M O Yagmurov, E L Troshin
The injuries to the maxillofacial region (MFR) are among the most frequently occurring problems encountered if the forensic medical practice. The objective of the present study was the analysis of the quality of the medical record documentation of the victims of the injuries to the maxillofacial region for obtaining the information necessary for forensic medical experts to make the well-founded conclusions. We undertook the in-depth analysis of random samples from the materials stored in the archive of living subjects at the Saint-Petersburg Bureau of forensic medical expertise for the period from 2010 to 2014...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667635/-the-application-of-the-biometriclal-dactylography-17-0-program-complex-for-the-digital-interpretation-of-the-finger-dermatoglyphic-features
#17
V N Zvyagin, V A Rakitin, E E Fomina
The objective of the present study was the development of the computer software for the scale-free interpretation of the finger dermatoglyphic features needed for the objective comprehensive evaluation of their principal characteristics in the digital terms. We have elaborated the program complex making it possible to address the following problems: thr formulation of the database of electronic copies of the finger print and toe print images in the family groups, the display of the finger print and toe print images on the screen, marking the points and lines for automated readout of digital angular and metric information or automated calculation of relative values, the formulation of the database of digital information about the papillary patterns on the fingers and toes in the family triplets (farther + mother + child) and its import into an Excel file...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667634/-the-dynamics-of-the-dimensional-characteristics-of-the-sella-turcica-in-the-subjects-above-20-years-of-age
#18
Yu I Pigolkin, M D Ametrin, G V Zolotenkova
The objective of the present study was to determine the biological age of the unidentified dead subjects based on the morphometric characteristics of the sella turcica in comparison with other methods available for the purpose in order to narrow the range of the alleged ages of the human remains being examined. The parameters of the sella turcica were measured in the corpses immediately after cephalotomy provided no pathological changes could be identified in the sellar region. A total of 86 skulls of the Caucasoid subjects representing the Eastern-Slavic group at the age varying from 22 to 87 years were available for the examination...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667632/-the-peculiar-biochemical-properties-of-the-support-structures-in-the-human-tissues
#19
S G Kuzin, S G Sukhanov, Ya V Kazakov, A V Pyatlin
This article is focused on the methodological aspects of the evaluation of the elastic and mechanical strength characteristics of the tissues that form the flexible fibrous and osseous human skeleton. The samples of dura mater and spongy bone (ribs) were subjected to the quantitative analysis for the determination of their bioelemental composition. The study has demonstrated that the force needed to brake dura mater or a rib correlates with the content of biological elements in these tissue, as well as with the age and sex of the human subjects serving as teir sources...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667630/-the-principal-and-auxiliary-immunohistochemical-markers-of-intravital-mechanical-strangulation-asphyxia
#20
D V Bogomolov, V A Fetisov, O P Denisova, Yu V Zbrueva, G G Semenov
The objective of the present study was the evaluation of the auxiliary methods for the diagnostics of the intravital formation of the constriction marks; the secondary objective was to determine the pace at which the death and asphyxia occur. MATERIAL AND METHODS: The materials on which the study was based included 17 cases of mechanical strangulation asphyxia involving 13 men and 4 women at the age from 8 to 28 years. All cases of hanging were associated with different blood alcohol levels...
2018: Sudebno-meditsinskaia Ekspertiza
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