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https://www.readbyqxmd.com/read/28408209/role-of-mir-34a-in-tgf-%C3%AE-1-and-drug-induced-epithelial-mesenchymal-transition-in-alveolar-type-ii-epithelial-cells
#1
Mikihisa Takano, Chinami Nekomoto, Masashi Kawami, Ryoko Yumoto
Epithelial-mesenchymal transition (EMT) of alveolar type II epithelial cells may play an important role in the pulmonary fibrosis induced by drugs such as bleomycin (BLM) and methotrexate (MTX). In this study, we examined the role of microRNAs (miRNAs) in drug-induced EMT using RLE/Abca3, a cell line having alveolar type II cell-like phenotype. Based on the screening using miRNA microarray analysis, it was found that the expression of some miRNAs, such as miR-34a, was increased by transforming growth factor (TGF)-β1 and BLM...
April 10, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28318025/maternal-chronic-hypoxia-increases-expression-of-genes-regulating-lung-liquid-movement-and-surfactant-maturation-in-male-fetuses-in-late-gestation
#2
Erin V McGillick, Sandra Orgeig, Beth J Allison, Kirsty L Brain, Youguo Niu, Nozomi Itani, Katie L Skeffington, Andrew D Kane, Emilio A Herrera, Dino A Giussani, Janna L Morrison
Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of the hypoxaemic insult. We have isolated the effect of maternal chronic hypoxia (MCH) for a month in late gestation on fetal lung development. Pregnant ewes were exposed to normoxia (21% O2 ) or hypoxia (10% O2 ) from 105-138 d gestation (term ∼145 d). At 138 d, gene expression in fetal lung tissue was determined by qRT-PCR...
March 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28241820/examining-the-role-of-abc-lipid-transporters-in-pulmonary-lipid-homeostasis-and-inflammation
#3
REVIEW
Amanda B Chai, Alaina J Ammit, Ingrid C Gelissen
Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pulmonary inflammation. Three ATP-binding cassette (ABC) transporters are found in the mammalian lung - ABCA1, ABCG1 and ABCA3 - that are involved in movement of cholesterol and phospholipids from lung cells...
February 28, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28215425/outcomes-of-lung-transplantation-for-infants-and-children-with-genetic-disorders-of-surfactant-metabolism
#4
Whitney B Eldridge, Qunyuan Zhang, Albert Faro, Stuart C Sweet, Pirooz Eghtesady, Aaron Hamvas, F Sessions Cole, Jennifer A Wambach
OBJECTIVE: To compare outcomes of infants and children who underwent lung transplantation for genetic disorders of surfactant metabolism (SFTPB, SFTPC, ABCA3, and NKX2-1) over 2 epochs (1993-2003 and 2004-2015) at St Louis Children's Hospital. STUDY DESIGN: We retrospectively reviewed clinical characteristics, mortality, and short- and long-term morbidities of infants (transplanted at <1 year; n = 28) and children (transplanted >1 year; n = 16) and compared outcomes by age at transplantation (infants vs children) and by epoch of transplantation...
May 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28034695/aberrant-lung-remodeling-in-a-mouse-model-of-surfactant-dysregulation-induced-by-modulation-of-the-abca3-gene
#5
Michael F Beers, Lars Knudsen, Yaniv Tomer, Julian Maronn, Ming Zhao, Matthias Ochs, Surafel Mulugeta
The lipid transporter, ATP binding cassette class A3 (ABCA3), plays a critical role in the biogenesis of alveolar type 2 (AT2) cell lamellar bodies (LBs). A relatively large number of mutations in the ABCA3 gene have been identified in association with diffuse parenchymal lung disease (DPLD), the most common of which is a missense mutation (valine substitution for lysine at residue 292 (ABCA3(E292V))) that leads to functional impairment of the transporter in vitro. The consequences of ABCA3(E292)(V) gene expression in vivo are unknown...
March 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28025703/the-biology-of-the-abca3-lipid-transporter-in-lung-health-and-disease
#6
REVIEW
Michael F Beers, Surafel Mulugeta
The lipid transporter, ATP-binding cassette class A3 (ABCA3), is a highly conserved multi-membrane-spanning protein that plays a critical role in the regulation of pulmonary surfactant homeostasis. Mutations in ABCA3 have been increasingly recognized as one of the causes of inherited pulmonary diseases. These monogenic disorders produce familial lung abnormalities with pathological presentations ranging from neonatal surfactant-deficiency-induced respiratory failure to childhood or adult diffuse parenchymal lung diseases for which specific treatment modalities remain limited...
March 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28002023/valproic-acid-vpa-enhances-cisplatin-sensitivity-of-non-small-cell-lung-cancer-cells-via-hdac2-mediated-down-regulation-of-abca1
#7
Jian-Hui Chen, Yu-Long Zheng, Chuan-Qin Xu, Li-Zhi Gu, Zong-Li Ding, Ling Qin, Yi Wang, Ran Fu, Yu-Feng Wan, Cheng-Ping Hu
Valproic acid (VPA) has been suggested to be a histone deacetylase inhibitor (HDACI). Our present study revealed that VPA at 1 mM, which had no effect on cell proliferation, can significantly increase the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP). VPA treatment markedly decreased the mRNA and protein levels of ABCA1, while had no significant effect on ABCA3, ABCA7 or ABCB10. Luciferase reporter assays showed that VPA can decrease the ABCA1 promoter activity in both A549 and H358 cells...
December 20, 2016: Biological Chemistry
https://www.readbyqxmd.com/read/27967234/alternative-progenitor-lineages-regenerate-the-adult-lung-depleted-of-type-ii-cells
#8
Min Yee, William Domm, Robert Gelein, Karen L de Mesy Bentley, R Matthew Kottmann, Patricia J Sime, B Paige Lawrence, Michael A O'Reilly
An aberrant oxygen environment at birth increases the severity of respiratory viral infections later in life through poorly understood mechanisms. Here we show that alveolar epithelial type II (AEC2) cells, a progenitor for AEC1 cells are depleted in adult mice exposed to neonatal hypoxia or hyperoxia. Airway cells expressing SP-C and ABCA3, alveolar pod cells expressing KRT5, and pulmonary fibrosis was observed when these mice were infected with a sublethal dose of HKx31, H3N2 influenza A virus (IAV). This was not seen in infected siblings birthed into room air...
December 14, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27784479/-pulmonary-surfactant-protein-adenosine-triphosphate-binding-cassette-a3-gene-composite-mutations-in-infant-congenital-interstitial-lung-disease-report-of-a-case-and-review-of-literature
#9
N Xie, D H Chen, Y N Lin, S Z Wu, Y Y Gu, Q S Zeng, Y Y Zhai, L Y Yang, J X Xu
Objective: To report a case of the pulmonary surfactant protein(SP) adenosine triphosphate-binding-cassette-A3 (ABCA3) gene mutations in infant congenital interstitial lung disease(ILD), and review the related literature, to investigate the relationships of ABCA3 gene mutation associated with ILD in infants. Method: A 6-months-old boy was hospitalized in the department of Pediatrics of the First Affiliated Hospital of Guangzhou Medical University. The clinical, radiological, histological information from transbronchial lung biopsy (TBLB) and genetic testing in this case was analyzed; 12 reports retrieved on literature search at Pubmed, OVID databases from 2004 to 2015 by using the ABCA3 as keyword were reviewed and analyzed...
October 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27688707/novel-biomarker-candidates-for-colorectal-cancer-metastasis-a-meta-analysis-of-in-vitro-studies
#10
Nguyen Phuoc Long, Wun Jun Lee, Nguyen Truong Huy, Seul Ji Lee, Jeong Hill Park, Sung Won Kwon
Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes...
2016: Cancer Informatics
https://www.readbyqxmd.com/read/27670912/fatal-respiratory-disease-due-to-a-homozygous-intronic-abca3-mutation-a-case-report
#11
Harry Pachajoa, Felipe Ruiz-Botero, Luis Enrique Meza-Escobar, Vania Alexandra Villota-Delgado, Adriana Ballesteros, Ivan Padilla, Diana Duarte
BACKGROUND: Pulmonary surfactant is a complex mixture of lipids and proteins. Mutations in surfactant protein-C, surfactant protein-D, and adenosine triphosphate-binding cassette subfamily A member 3 have been related to surfactant dysfunction and neonatal respiratory failure in full-term babies. Adenosine triphosphate-binding cassette subfamily A member 3 facilitates the transfer of lipids to lamellar bodies. We report the case of patient with a homozygous intronic ABCA3 mutation. CASE PRESENTATION: We describe a newborn full-term Colombian baby boy who was the son of non-consanguineous parents of mixed race ancestry (Mestizo), who was delivered with severe respiratory depression...
September 26, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27521922/phylogenetic-analysis-of-the-atp-binding-cassette-transporter-family-in-three-mosquito-species
#12
Hong Lu, Yongyu Xu, Feng Cui
The ATP-binding cassette (ABC) transporter family functions in the ATP-dependent transportation of various substrates across biological membranes. ABC proteins participate in various biological processes and insecticide resistance in insects, and are divided into eight subfamilies (A-H). Mosquitoes are important vectors of human diseases, but the mechanism by which the ABC transporter family evolves in mosquitoes is unknown. In this study, we classified and compared the ABC transporter families of three mosquitoes, namely, Anopheles gambiae, Aedes aegypti, and Culex pipiens quinquefasciatus...
September 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27516224/lung-disease-caused-by-abca3-mutations
#13
Carolin Kröner, Thomas Wittmann, Simone Reu, Veronika Teusch, Mathias Klemme, Daniela Rauch, Meike Hengst, Matthias Kappler, Nazan Cobanoglu, Tugba Sismanlar, Ayse T Aslan, Ilaria Campo, Marijke Proesmans, Thomas Schaible, Susanne Terheggen-Lagro, Nicolas Regamey, Ernst Eber, Jürgen Seidenberg, Nicolaus Schwerk, Charalampos Aslanidis, Peter Lohse, Frank Brasch, Ralf Zarbock, Matthias Griese
BACKGROUND: Knowledge about the clinical spectrum of lung disease caused by variations in the ATP binding cassette subfamily A member 3 (ABCA3) gene is limited. Here we describe genotype-phenotype correlations in a European cohort. METHODS: We retrospectively analysed baseline and outcome characteristics of 40 patients with two disease-causing ABCA3 mutations collected between 2001 and 2015. RESULTS: Of 22 homozygous (15 male) and 18 compound heterozygous patients (3 male), 37 presented with neonatal respiratory distress syndrome as term babies...
August 11, 2016: Thorax
https://www.readbyqxmd.com/read/27512515/adenosine-triphosphate-binding-cassette-member-a3-gene-mutation-in-children-from-one-family-from-saudi-arabia
#14
Gawahir Mohamed Ahmed Mukhtar, Wadha Hilal Al Otaibi, Khalid Fahad Abdullah Al-Mobaireek, Suhail Al-Saleh
Mutation in ABCA3, which is adenosine triphosphate-binding cassette member A3, a member of protein transporter family for phospholipids into the lamellar bodies during synthesis of surfactant, can cause lung disease related to surfactant dysfunction with autosomal recessive pattern. We reported three cases from same family with ABCA3 mutation, their gene, clinical course, and outcomes mentioning that one patient had successful lung transplantation, one started the process of the lung transplantation while the third one died during infancy...
July 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27491559/neo-tanshinlactone-selectively-inhibits-the-proliferation-of-estrogen-receptor-positive-breast-cancer-cells-through-transcriptional-down-regulation-of-estrogen-receptor-alpha
#15
Wanjun Lin, Jiajun Huang, Xiaolin Liao, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma
Breast cancer, the most frequent cancer in women, is the second leading cause of cancer-related death. Estrogens and estrogen receptors are well recognized to play predominant roles in breast cancer development and growth. Neo-tanshinlactone is a natural product isolated from Salvia miltiorrhiza and showed selective growth inhibition of ER+ breast cancer cell lines as demonstrated by cell proliferation assay and colony formation assay. The selective anti-proliferative effect of neo-tanshinlactone was associated with the induction of apoptosis in ER+ breast cancer cells...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27437095/novel-mutation-in-the-atp-binding-cassette-transporter-a3-abca3-encoding-gene-causes-respiratory-distress-syndrome-in-a-term-newborn-in-southwest-iran
#16
Farideh Rezaei, Mohammad Shafiei, Gholamreza Shariati, Ali Dehdashtian, Maryam Mohebbi, Hamid Galehdari
INTRODUCTION: ABCA3 glycoprotein belongs to the ATP-binding cassette (ABC) superfamily of transporters, which utilize the energy derived from hydrolysis of ATP for the translocation of a wide variety of substrates across the plasma membrane. Mutations in the ABCA3 gene are knowingly causative for fatal surfactant deficiency, particularly respiratory distress syndrome (RDS) in term babies. CASE PRESENTATION: In this study, Sanger sequencing of the whole ABCA3 gene (NCBI NM_001089) was performed in a neonatal boy with severe RDS...
April 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27374344/functional-characterization-of-atp-binding-cassette-transporter-a3-mutations-from-infants-with-respiratory-distress-syndrome
#17
Jennifer A Wambach, Ping Yang, Daniel J Wegner, Hillary B Heins, Lyudmila N Kaliberova, Sergey A Kaliberov, David T Curiel, Frances V White, Aaron Hamvas, Brian P Hackett, F Sessions Cole
Mutations in the ATP-binding cassette transporter A3 gene (ABCA3) result in severe neonatal respiratory distress syndrome and childhood interstitial lung disease. As most ABCA3 mutations are rare or private, determination of mutation pathogenicity is often based on results from in silico prediction tools, identification in unrelated diseased individuals, statistical association studies, or expert opinion. Functional biologic studies of ABCA3 mutations are needed to confirm mutation pathogenicity and inform clinical decision making...
November 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27352740/homooligomerization-of-abca3-and-its-functional-significance
#18
Sabrina Frixel, Amelie S Lotz-Havla, Sunčana Kern, Eva Kaltenborn, Thomas Wittmann, Søren W Gersting, Ania C Muntau, Ralf Zarbock, Matthias Griese
ABCA3 is a surfactant lipid transporter in the limiting membrane of lamellar bodies in alveolar type II cells. Mutations in the ATP-binding cassette, sub-family A (ABC1), member 3 (ABCA3) gene cause respiratory distress syndrome in newborns, and chronic interstitial lung disease in children and adults. ABCA3 belongs to the class of full ABC transporters, which are supposed to be functional in their monomeric forms. Although other family members e.g., ABCA1 and ABCC7 have been shown to function as oligomers, the oligomerization state of ABCA3 is unknown...
August 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27236157/%C3%A2-thymosin-%C3%AE-10-as-a-predictive-biomarker-of-response-to-5-fluorouracil-chemotherapy-in-cholangiocarcinoma
#19
Sirinapa Sribenja, Nichapavee Natthasirikul, Kulthida Vaeteewoottacharn, Kanlayanee Sawanyawisuth, Chaisiri Wongkham, Patcharee Jearanaikoon, Sopit Wongkham
UNLABELLED:  Introduction and aim. 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic drug in the treatment of cholangiocarcinoma (CCA). Since development of drug resistance to 5-FU in CCA patients is the primary cause of treatment failure, a better understanding of the mechanism of drug resistance of this cancer is essential to improve the efficacy of 5-FU in CCA therapy. MATERIAL AND METHODS: A 5-FU resistant CCA cell line (M214-5FUR) for a comparative chemo-resistance study was established...
July 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27190064/bmp-signaling-is-essential-in-neonatal-surfactant-production-during-respiratory-adaptation
#20
Yongfeng Luo, Hui Chen, Siying Ren, Nan Li, Yuji Mishina, Wei Shi
Deficiency in pulmonary surfactant results in neonatal respiratory distress, and the known genetic mutations in key components of surfactant only account for a small number of cases. Therefore, determining the regulatory mechanisms of surfactant production and secretion, particularly during the transition from prenatal to neonatal stages, is essential for better understanding of the pathogenesis of human neonatal respiratory distress. We have observed significant increase of bone morphogenetic protein (BMP) signaling in neonatal mouse lungs immediately after birth...
July 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
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