Jacqueline Heger, Stefan Partsch, Claudia Harjung, Zoltán V Varga, Tamás Baranyai, Johannes Weiß, Lea Kremer, Fabian Locquet, Przemyslaw Leszek, Bence Ágg, Bettina Benczik, Péter Ferdinandy, Rainer Schulz, Gerhild Euler
Cardiac hypertrophy resulting from sympathetic nervous system activation triggers the development of heart failure. The transcription factor Y-box binding protein 1 (YB-1) can interact with transcription factors involved in cardiac hypertrophy and may thereby interfere with the hypertrophy growth process. Therefore, the question arises as to whether YB-1 influences cardiomyocyte hypertrophy and might thereby influence the development of heart failure. YB-1 expression is downregulated in human heart biopsies of patients with ischemic cardiomyopathy ( n = 8), leading to heart failure...
December 28, 2023: International Journal of Molecular Sciences