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https://www.readbyqxmd.com/read/29670170/y-box-protein-associated-acidic-protein-ybap1-c1qbp-affects-the-localization-and-cytoplasmic-functions-of-yb-1
#1
Ken Matsumoto, Shingo Kose, Iku Kuwahara, Mami Yoshimura, Naoko Imamoto, Minoru Yoshida
The Y-box proteins are multifunctional nucleic acid-binding proteins involved in various aspects of gene regulation. The founding member of the Y-box protein family, YB-1, functions as a transcription factor as well as a principal component of messenger ribonucleoprotein particles (mRNPs) in somatic cells. The nuclear level of YB-1 is well correlated with poor prognosis in many human cancers. Previously, we showed that a Y-box protein-associated acidic protein, YBAP1, which is identical to complement component 1, q subcomponent-binding protein (C1QBP, also called gC1qR, hyaluronan-binding protein 1 [HABP1] or ASF/SF2-associated protein p32), relieves translational repression by YB-1...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669280/the-long-non-coding-rna-lnc-31-interacts-with-rock1-mrna-and-mediates-its-yb-1-dependent-translation
#2
Dacia Dimartino, Alessio Colantoni, Monica Ballarino, Julie Martone, Davide Mariani, Johannes Danner, Astrid Bruckmann, Gunter Meister, Mariangela Morlando, Irene Bozzoni
Cytoplasmic long non-coding RNAs have been shown to act at many different levels to control post-transcriptional gene expression, although their role in translational control is poorly understood. Here, we show that lnc-31, a non-coding RNA required for myoblast proliferation, promotes ROCK1 protein synthesis by stabilizing its translational activator, YB-1. We find that lnc-31 binds to the Rock1 mRNA as well as to the YB-1 protein and that translational activation requires physical interaction between the two RNA species...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29590660/the-role-of-y-box-binding-protein-1-in-kidney-injury-friend-or-foe
#3
Ben Ke, Chuqiao Fan, Weiping Tu, Xiangdong Fang
Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes via the transcriptional and translational regulation of target gene expression. YB-1 promotes acute or chronic kidney injury through multiple molecular pathways; however, accumulating evidence suggests that significantly increased YB-1 levels are of great importance in renoprotection. In addition, YB-1 may contribute to obesity-related kidney disease by promoting adipogenesis. Thus, the role of YB-1 in kidney injury is complicated, and no comprehensive review is currently available...
March 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29559746/mutant-kras-promotes-liver-metastasis-of-colorectal-cancer-in-part-by-upregulating-the-mek-sp1-dnmt1-mir-137-yb-1-igf-ir-signaling-pathway
#4
Po-Chen Chu, Peng-Chan Lin, Hsing-Yu Wu, Kuen-Tyng Lin, Christina Wu, Tanios Bekaii-Saab, Yih-Jyh Lin, Chung-Ta Lee, Jeng-Chang Lee, Ching-Shih Chen
Although the role of insulin-like growth factor-I receptor (IGF-IR) in promoting colorectal liver metastasis is known, the mechanism by which IGF-IR is upregulated in colorectal cancer (CRC) is not defined. In this study, we obtained evidence that mutant KRAS transcriptionally activates IGF-IR gene expression through Y-box-binding protein (YB)-1 upregulation via a novel MEK-Sp1-DNMT1-miR-137 pathway in CRC cells. The mechanistic link between the tumor suppressive miR-137 and the translational regulation of YB-1 is intriguing because epigenetic silencing of miR-137 represents an early event in colorectal carcinogenesis due to promoter hypermethylation...
March 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29554146/evaluation-of-classical-and-novel-autoantibodies-for-the-diagnosis-of-primary-biliary-cholangitis-autoimmune-hepatitis-overlap-syndrome-pbc-aih-os
#5
Henry H Nguyen, Abdel Aziz Shaheen, Natalia Baeza, Ellina Lytvyak, Stefan J Urbanski, Andrew L Mason, Gary L Norman, Marvin J Fritzler, Mark G Swain
BACKGROUND AND AIMS: Up to 20% of Primary Biliary Cholangitis (PBC) patients are estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH overlap syndrome (PBC-AIH OS) have been reported to exhibit suboptimal responses to ursodeoxycholic acid therapy, and are more likely to progress to cirrhosis. Anti-double stranded DNA (anti-dsDNA) and anti-p53 have been previously suggested to be potential autoantibodies for identifying patients with PBC-AIH OS...
2018: PloS One
https://www.readbyqxmd.com/read/29529249/perk-eif2%C3%AE-signaling-inhibits-hif-induced-gene-expression-during-the-unfolded-protein-response-via-yb1-dependent-regulation-of-hif1%C3%AE-translation
#6
Iglika G Ivanova, Catherine V Park, Adrian I Yemm, Niall S Kenneth
HIF1α (hypoxia inducible factor 1α) is the central regulator of the cellular response to low oxygen and its activity is deregulated in multiple human pathologies. Consequently, given the importance of HIF signaling in disease, there is considerable interest in developing strategies to modulate HIF1α activity and down-stream signaling events. In the present study we find that under hypoxic conditions, activation of the PERK branch of the unfolded protein response (UPR) can suppress the levels and activity of HIF1α by preventing efficient HIF1α translation...
February 26, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29517281/yb-1-promotes-laryngeal-squamous-cell-carcinoma-progression-by-inducing-mir-155-expression-via-c-myb
#7
Xudong Zhao, Wei Zhang, Wenyue Ji
AIM: In this study, we investigated the role of Y-box binding protein-1 (YB-1), c-Myb and miR-155 in human laryngeal squamous cell carcinoma (LSCC) progression. MATERIALS & METHODS: Quantitative real-time PCR, western blot, MTT and Transwell were conducted to determine the expression and function of YB-1/miR-155 pathway. Univariate and multivariate analyses were used to determine the prognostic factors. RESULTS: Expression of YB-1, c-Myb and miR-155 was higher in LSCC tissues...
March 8, 2018: Future Oncology
https://www.readbyqxmd.com/read/29486702/y-box-binding-protein-1-stimulates-abasic-site-cleavage
#8
E E Alemasova, K N Naumenko, N A Moor, O I Lavrik
Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions. The first step in the AP site repair involves the magnesium-dependent enzyme AP endonuclease 1 (APE1) that catalyzes hydrolytic cleavage of the DNA phosphodiester bond at the 5' side of the AP site, thereby generating a single-strand DNA break flanked by the 3'-OH and 5'-deoxyribose phosphate (dRP) groups. Increased APE1 activity in cancer cells might correlate with tumor chemoresistance to DNA-damaging treatment. It has been previously shown that the multifunctional oncoprotein Y-box-binding protein 1 (YB-1) interacts with APE1 and inhibits APE1-catalyzed hydrolysis of AP sites in single-stranded DNAs...
December 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29457716/metal-versus-ligand-reduction-in-ln-3-complexes-of-a-mesitylene-anchored-tris-aryloxide-ligand
#9
Chad T Palumbo, Dominik P Halter, Vamsee K Voora, Guo P Chen, Alan K Chan, Megan E Fieser, Joseph W Ziller, Wolfgang Hieringer, Filipp Furche, Karsten Meyer, William J Evans
The synthesis of 4fn Ln3+ complexes of the tris(aryloxide) mesitylene ligand, ((Ad,Me ArO)3 mes)3- , with Ln = La, Ce, Pr, Sm, and Yb, and their reduction with potassium have revealed that this ligand system can be redox active with some metals. Protonolysis of [Ln(N(SiMe3 )2 )3 ] (Ln = La, Ce, Pr, Sm, Yb) with the tris(phenol) (Ad,Me ArOH)3 mes yielded the Ln3+ complexes [((Ad,Me ArO)3 mes)Ln] (Ln = La, Ce, Pr, Sm, Yb), 1-Ln. Single electron reduction of each 4fn complex, 1-Ln, using potassium yielded the reduced products, [K(2...
February 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29429449/investigation-of-function-and-regulation-of-the-yb-1-cellular-factor-in-hiv-replication
#10
Yu-Mi Jung, Kyung-Lee Yu, Seong-Hyun Park, Seong-Deok Lee, Min-Jeong Kim, Ji-Chang You
Y-box binding protein 1 (YB-1) is a member of the cold-shock domain (CSD) protein superfamily. It participates in a wide variety of cellular events, including transcription, RNA splicing, translation, DNA repair, drug resistance, and stress responses. We investigated putative functions of YB-1 in HIV-1 replication. Functional studies using overexpression or knockdown of YB-1 in conjunction with transfection of proviral DNA showed that YB-1 enhances virus production. We found YB-1 regulates HIV-1 production by stimulating viral transcription using HIV-1 LTR sequence U3RU5 with Luciferase assay...
February 12, 2018: BMB Reports
https://www.readbyqxmd.com/read/29353823/increased-expression-of-y-box-binding-protein-1-in-hind-limb-muscles-during-regeneration-from-ischemic-injury-in-mice
#11
Megumi Fuke, Makoto Narita, Yuko Wada, Tatsuichiro Seto, Kenji Okada, Jun Nakayama, Hiroto Izumi, Ken-Ichi Ito
Critical limb ischemia (CLI) is the most severe complication of peripheral arterial disease (PAD). Understanding the molecular mechanisms underlying tissue repair after CLI is necessary for preventing PAD progression. Y-box binding protein-1 (YB-1) regulates the expression of many genes in response to environmental stresses. We aimed to determine whether YB-1 is involved in ischemic muscle regeneration. A mouse ischemic hind-limb model was generated; namely, the femoral, saphenous, and popliteal arteries in the left hind limb were ligated...
January 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29320405/effect-of-shrna-mediated-silencing-of-yb-1-protein-on-the-expression-of-matrix-collagenases-in-malignant-melanoma-cell-in-vitro
#12
Wisam Nabeel Ibrahim, Abd Almonem Doolaanea, Mohammad Syaiful Bahari Bin Abdull Rasad
Background and Objective: YB-1 is a transcription and oncogenic factor capable of binding to DNA and RNA performing versatile functions within normal and cancer cells. Some studies reported the binding of YB-1 with a collagenases gene promoter and influencing their expression. In addition, the role of YB-1 in malignant melanoma was not elucidated. Thus, in this study, the aim was to knock down the expression of YB-1 in A375 malignant melanoma cancer cell using the shRNA approach and study its effect on cancer cell proliferation, migration, and expression of collagenases...
January 10, 2018: Cells
https://www.readbyqxmd.com/read/29277610/the-transcriptional-factor-yb-1-positively-regulates-hsc70-transcription-in-crassostrea-hongkongensis
#13
Huiru Liu, Delin Xu, Miao Cui, Tinglong Hou, Qizhong Zhang
A Y-box binding protein ChYB-1 was discovered as a ChHsc70 promoter-associated protein in Crassostrea hongkongensis by DNA-affinity purification and mass spectrometry analysis. The overexpression of ChYB-1 in heterologous HEK293T cells led to clear enhancement of ChHsc70 promoter expression, while ChYB-1 depletion correlated with significant reduction of ChHsc70 transcription in the hemocytes of C. hongkongensis. Quantitative Real-time PCR analysis revealed that both ChHsc70 and ChYB-1 were transcriptionally responsive to external chemical or physical stressors...
January 22, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29274785/indirubin-3-oxime-inhibits-anticancer-agent-induced-yb-1-nuclear-translocation-in-hepg2-human-hepatocellular-carcinoma-cells
#14
Toru Tanaka, Sachiyo Ohashi, Hiroaki Saito, Taira Wada, Tadashi Aoyama, Yoshimi Ichimaru, Shinichi Miyairi, Shunsuke Kobayashi
Hepatocellular carcinoma (HCC) is a disease with poor prognosis. Nuclear accumulation of YB-1 is closely related to the malignancy of HCC. Treatment with anticancer agents often induces translocation of YB-1 from cytoplasm to nucleus and activates the expression of multidrug resistance gene 1 (MDR1). Therefore, any effective inhibitor of this phenomenon would be useful for cancer treatment. Here we examined various indirubin derivatives and found that indirubin 3'-oxime inhibits actinomycin D-induced nuclear transport of YB-1 and suppresses the activation of MDR1 gene expression in the human hepatocellular carcinoma cell line HepG2...
January 29, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29246296/antisense-oligonucleotides-targeting-y-box-binding-protein-1-inhibit-tumor-angiogenesis-by-downregulating-bcl-xl-vegfr2-tie-axes
#15
Kiyoko Setoguchi, Lin Cui, Nobutaka Hachisuka, Sumalee Obchoei, Kentaro Shinkai, Fuminori Hyodo, Kiyoko Kato, Fumito Wada, Tsuyoshi Yamamoto, Mariko Harada-Shiba, Satoshi Obika, Kenji Nakano
Y-box binding protein-1 (YB-1), involved in cancer progression and chemoradiation resistance, is overexpressed in not only cancer cells but also tumor blood vessels. In this study, we investigated the potential value of amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) targeting YB-1 (YB-1 ASOA ) as an antiangiogenic cancer therapy. YB-1 ASOA was superior to natural DNA-based ASO or locked nucleic acid (LNA)-modified YB-1 ASO in both knockdown efficiency and safety, the latter assessed by liver function...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29187452/y-box-binding-protein-1-enhances-oncogenic-transforming-growth-factor-%C3%AE-signaling-in-breast-cancer-cells-via-triggering-phospho-activation-of-smad2
#16
Matthias B Stope, Martin Weiss, Dominique Koensgen, Simone L Popp, Christian Joffroy, Alexander Mustea, Miriam B Buck, Cornelius Knabbe
BACKGROUND/AIM: Transforming growth factor β (TGFβ) plays a role in diverse oncogenic pathways including cell proliferation and cell motility and is regulated by the pleiotropic factor Y-box binding protein-1 (YB-1). In breast cancer, Sma/Mad related protein 2 (Smad2) represents the most common downstream transducer in TGFβ signaling. MATERIALS AND METHODS: Here, YB-1's impact on Smad2 phospho-activation was characterized by incubation of the breast cancer cell line MCF-7 with or without TGFβ1 in the absence or presence of overexpressed YB-1 protein...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29133115/structural-features-of-the-interaction-of-the-3-untranslated-region-of-mrna-containing-exosomal-rna-specific-motifs-with-yb-1-a-potential-mediator-of-mrna-sorting
#17
Darya D Yanshina, Olga A Kossinova, Alexander V Gopanenko, Olga A Krasheninina, Alexey A Malygin, Alya G Venyaminova, Galina G Karpova
We have previously shown that YB-1 is the only protein of the HEK293 cell cytoplasmic (S100) extract that specifically interacts with RNA hairpins each containing one of the motifs ACCAGCCU (1), CAGUGAGC (2) and UAAUCCCA (3), which had been identified as often found in exosomal RNA and proposed as potential cis-acting elements targeting RNAs into exosomes. Here we explored the interactions of YB-1 with a fragment of the 3'-untranslated region (UTR) of septin 14 mRNA (SEPT14 RNA), which contains all three motifs...
January 2018: Biochimie
https://www.readbyqxmd.com/read/29126263/notch-signaling-regulates-differentiation-and-steroidogenesis-in-female-mouse-ovarian-granulosa-cells
#18
Rexxi D Prasasya, Kelly E Mayo
The Notch pathway is a highly conserved juxtacrine signaling mechanism that is important for many cellular processes during development, including differentiation and proliferation. Although Notch is important during ovarian follicle formation and early development, its functions during the gonadotropin-dependent stages of follicle development are largely unexplored. We observed positive regulation of Notch activity and expression of Notch ligands and receptors following activation of the luteinizing hormone-receptor in prepubertal mouse ovary...
January 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29119395/comparative-analysis-of-quantitative-parameters-of-expression-of-the-retinoic-acid-nuclear-receptor-rar%C3%AE-gene-and-ape1-yb-1-mdr1-pattern-genes-in-patients-with-newly-detected-multiple-myeloma
#19
N N Kalitin, Yu B Chernykh, I V Buravtsova
The expression of retinoic acid nuclear receptor gene RARα and its relationship with expression of APE1, YB-1, and MDR1 genes was studied in bone marrow aspiration biopsy specimens from 22 patients with newly detected multiple myeloma. The expression of RARα directly correlated with the expression of APE1/YB-1/MDR1 pattern genes. Groups differing by expression of RARα exhibited significant differences in the overall survival of patients; concordant and simultaneous changes in the expression of all genes of the APE1/YB-1/MDR1 pattern suggested the level of RARα gene expression as a potential prognostic factor in the pathogenesis of multiple myeloma...
November 9, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29113949/dysregulated-expression-of-the-microrna-mir-137-and-its-target-ybx1-contribute-to-the-invasive-characteristics-of-malignant-pleural-mesothelioma
#20
Thomas G Johnson, Karin Schelch, Yuen Y Cheng, Marissa Williams, Kadir H Sarun, Michaela B Kirschner, Steven Kao, Anthony Linton, Sonja Klebe, Brian C McCaughan, Ruby C Y Lin, Christine Pirker, Walter Berger, Annette Lasham, Nico van Zandwijk, Glen Reid
INTRODUCTION: Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterized by frequent chromosomal deletions of tumor suppressors, including microRNAs. MiR-137 plays a tumor suppressor role in other cancers, so the aim of this study was to characterize it and its target Y-box binding protein 1 (YBX1) in MPM. METHODS: Expression, methylation, and copy number status of miR-137 and its host gene MIR137HG were assessed by polymerase chain reaction...
February 2018: Journal of Thoracic Oncology
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