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Lakshmi Adalagere Sathyanarayana, Vijayakumar M Heggeri, Parimala Prasanna Simha, Satish Narasimaiah, Manjunath Narasimaiah, Bharathi Katheraguppa Subbarao
INTRODUCTION: Levobupivacaine is the s-isomer of racemic Bupivacaine. It is less cardio, neurotoxic and equally potent local anaesthetic compared to its racemate. It is known to cause less Depression of myocardial contractility. Dexmeditomidine when used via epidural route has synergistic effect with local anaesthetics. Majority of patients presenting for vascular surgery are elderly and have associated co-morbidities like diabetes, hypertension, and coronary artery disease. We intend to study safety and efficacy of epidural Levoupivacaine and Dexmedetomidine in this group of patients...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Shankar V Kadam, Kamlesh B Tailor, Snehal Kulkarni, Smrutiranjan R Mohanty, Preetha V Joshi, Suresh G Rao
INTRODUCTION: Incidence of junctional ectopic tachycardia (JET) after repair of tetralogy of Fallot (TOF) is 5.6-14%. Dexmeditomidine is a a-2 adrenoceptor agonist modulates the release of catecholamine, resulting in bradycardia and hypotension. These effects are being explored as a therapeutic option for the prevention of perioperative tachyarrhythmia. We undertook this study to examine possible preventive effects of dexmedetomidine on postoperative JET and its impact on the duration of ventilation time and length of Intensive Care Unit stay...
July 2015: Annals of Cardiac Anaesthesia
Osama A Ibraheim, Alsiddiky Abdulmonem, Jumana Baaj, Tariq Al Zahrani, Vincent Arlet
BACKGROUND: Surgical correction ofscoliosis carries significant blood loss and needs for blood transfusion with its inherent risks and cost. The aim of this double-blind, randomized, controlled study was to compare the effects of esmolol or dexmedetomidine on intraoperative blood loss, anesthetics consumption, intra operative hemodynamic and effects on spinal cord monitoring in patients undergoing scoliosis surgery. METHODS: After obtaining institute review board approval and written informed consent, 60 adolescents (ASA physical status I-II), 14-18-year of age scheduled for posterior spinal fusion scoliosis surgery were enrolled in the study...
February 2013: Middle East Journal of Anesthesiology
H Alex Choi, Sang-Bae Ko, Mary Presciutti, Luis Fernandez, Amanda M Carpenter, Christine Lesch, Emily Gilmore, Rishi Malhotra, Stephan A Mayer, Kiwon Lee, Jan Claassen, J Michael Schmidt, Neeraj Badjatia
BACKGROUND: As the practice of aggressive temperature control has become more commonplace, new clinical problems are arising, of which shivering is the most common. Treatment for shivering while avoiding the negative consequences of many anti-shivering therapies is often difficult. We have developed a stepwise protocol that emphasizes use of the least sedating regimen to achieve adequate shiver control. METHODS: All patients treated with temperature modulating devices in the neurological intensive care unit were prospectively entered into a database...
June 2011: Neurocritical Care
Mohamad Said Takrouri, Mohamad Abdulla Seraj, Amir B Channa, Abdel Azeem el-Dawlatly, Ahmad Thallage, Walid Riad, Mazer Khalaf
BACKGROUND: Dexmedetomidine is a potent new alpha-2 adrenoceptor agonist with an alpha-2 to alpha- ratio more than 7 times that of clonidine. Its potent sedative, analgesic and sympatholytic effects blunt the cardiovascular responses (hypertension, tachycardia) without unexpected toxicity. Many reports confirmed its pharmacological properties if given by infusion. Recent report confirmed favorable non-depressant effect on respiration and blood gases. SETTING: ICU patients at King Khalid University Hospital...
October 2002: Middle East Journal of Anesthesiology
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