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https://www.readbyqxmd.com/read/29623588/recurrent-non-functioning-pituitary-adenomas-a-review-on-the-new-pathological-classification-management-guidelines-and-treatment-options
#1
REVIEW
P D Delgado-López, J Pi-Barrio, M T Dueñas-Polo, M Pascual-Llorente, M C Gordón-Bolaños
At least 50% of surgically resected non-functioning pituitary adenomas (NFPA) recur. Either early or late adjuvant radiotherapy is highly efficacious in controlling recurrent NFPA but associates potentially burdensome complications like hypopituitarism, vascular complications or secondary neoplasm. Reoperation is indicated in bulky tumor rests compressing the optic pathway. To date, no standardized medical therapy is available for recurrent NFPA although cabergoline and temozolomide show promising results. Guidelines on the management of recurrent NFPAs are now available...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29614359/transient-splenial-lesion-of-the-corpus-callosum-after-cabergoline-treatment
#2
Hayri Ogul, Serhat Kaya, Yasemin Ogul
No abstract text is available yet for this article.
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29569219/dopamine-d2-agonist-affects-visuospatial-working-memory-distractor-interference-depending-on-individual-differences-in-baseline-working-memory-span
#3
James M Broadway, Michael J Frank, James F Cavanagh
The interplay of dopaminergic striatal D1-D2 circuits is thought to support working memory (WM) by selectively filtering information that is to be remembered versus information to be ignored. To test this theory, we conducted an experiment in which healthy participants performed a visuospatial working memory (VSWM) task after ingesting the D2-receptor agonist cabergoline (or placebo), in a randomized, double-blinded, crossover design. Results showed greater interference from distractors under cabergoline, particularly for individuals with higher baseline dopamine (indicated by WM span)...
March 22, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29557627/-atypical-presentation-of-a-giant-prolactinoma-in-a-15-year-old-boy
#4
Elisa Vaiani, Cintia Morales, Florencia Soto, Yeny Blanco, Carlos Rugilo, Marta Ciaccio, Alicia Belgorosky
Giant prolactinomas are rare pituitary adenomas characterized by their great local invasion. In this paper, we report a 15-year-old male with left retro-ocular pain and ipsilateral exophthalmos of 4 months of evolution, secondary to a tumour in the base of the skull that invaded the orbit. Hormonal studies revealed serum prolactin of 6913,7 ng/ml (normal value < 20), confirming the diagnosis of giant prolactinoma. The patient started treatment with the dopaminergic agonist cabergoline in increasing doses...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29554822/evidence-for-the-involvement-of-the-dopaminergic-system-in-seizure-and-oxidative-damage-induced-by-tramadol
#5
Behnaz Bameri, Fatemeh Shaki, Nematollah Ahangar, Ramin Ataee, Mahedeh Samadi, Hamidreza Mohammadi
Tramadol (TR) is a synthetic analgesic drug with central function that can induce seizures even at therapeutic doses. The exact mechanism of TR effect on seizure generation is not clear, but inhibition of the serotonin and nitric oxide pathways and inhibitory effects on GABA receptors are the most common hypotheses about the seizure-inducing mechanism of the TR. This study aimed to evaluate the role of dopaminergic system on the seizure and oxidative damage induced by TR using agonist and antagonist drugs of this system in the Albino mice...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29546691/cabergoline-versus-bromocriptine-for-the-treatment-of-giant-prolactinomas-a-quantitative-and-systematic-review
#6
Hai Yan Huang, Shao Jian Lin, Wei Guo Zhao, Zhe Bao Wu
The aim of this study is to compare the efficacy of bromocriptine (BRC) versus cabergoline (CAB) in patients with giant prolactinomas. We searched MEDLINE, EMBASE, CENTRAL and Clinical Trials.gov for studies dated before March 1st, 2016, that used BRC or CAB for the treatment of patients with giant prolactinomas. Specific eligibility criteria were set to identify articles and cases. The selected articles were reviewed, and the data were extracted for analysis. The compared outcomes included tumor shrinkage, tumor response, normalization of prolactin (PRL) level, and visual field defect (VFD) improvement...
March 15, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29523633/management-of-endocrine-disease-management-of-cushing-s-syndrome-during-pregnancy-solved-and-unsolved-questions
#7
Thierry Brue, Vincent Amodru, Frédéric Castinetti
With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2-3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. The predominant cause is adrenal adenoma (sometimes without decreased ACTH), rather than Cushing's disease. There are considerable imaging pitfalls in Cushing's disease...
March 9, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29520805/treatment-escape-reduces-the-effectiveness-of-cabergoline-during-long-term-treatment-of-acromegaly-in-monotherapy-or-in-association-with-first-generation-somatostatin-receptor-ligands
#8
Leandro Kasuki, Marilia Duarte Dalmolin, Luiz Eduardo Armondi Wildemberg, Mônica R Gadelha
BACKGROUND: Few studies evaluated the use of cabergoline (CAB) for acromegaly treatment in monotherapy or in combination with first-generation somatostatin receptor ligands (SRLs). AIM: Evaluate the efficacy, predictors of response and safety of CAB treatment in acromegaly both in monotherapy and in combination with SRLs. METHODS: We retrospectively collected demographic, biochemical, tumor and treatment data. Short-term disease control was defined as random GH level <1...
March 9, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29492132/pituitary-apoplexy-during-treatment-of-prolactinoma-with-cabergoline
#9
Hesam Ghadirian, Mohamad Shirani, Shahab Ghazi-Mirsaeed, Saleh Mohebi, Maysam Alimohamadi
Pituitary apoplexy is a rare clinical presentation caused by infarction of the pituitary gland or adenoma with or without hemorrhage. Although pituitary apoplexy is usually spontaneous, one of the predisposing factors is treatment with dopamine agonists, especially bromocriptine. The occurrence of apoplexy during cabergoline therapy is reported much less frequently. In this article, we report a 34-year-old man with macroprolactinomas who developed sudden visual deterioration due to pituitary apoplexy 1 year after initiation of cabergoline therapy...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29467589/cabergoline-induced-pneumocephalus-following-treatment-for-giant-invasive-macroprolactinoma-presenting-with-spontaneous-cerebrospinal-fluid-rhinorrhea
#10
Souha S Elabd, Maswood M Ahmad, Sameer Q Qetab, Mussa Hussain Almalki
Cerebrospinal fluid (CSF) rhinorrhea is rarely reported as the first presenting feature of giant invasive macroprolactinomas. Cerebrospinal fluid rhinorrhea is usually reported as a complication of trauma, neurosurgical, and skull-based procedures (such as pituitary surgery or radiations), and less frequently after medical treatment with dopamine agonists (DAs) for macroprolactinomas. This phenomenon results from fistula creation that communicates between the subarachnoid space and the nasal cavity. Meanwhile, pneumocephalus is another well-recognized complication after transsphenoidal surgery for pituitary macroadenomas...
2018: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/29455199/clinical-features-and-response-to-treatment-of-prolactinomas-in-children-and-adolescents-a-retrospective-single-centre-analysis-and-review-of-the-literature
#11
Thomas Breil, Catherine Lorz, Daniela Choukair, Janna Mittnacht, Ioana Inta, Daniela Klose, Jessica Jesser, Egbert Schulze, Markus Bettendorf
BACKGROUND: Paediatric prolactinomas are rare. The aim of this study was to investigate the clinical features and outcome of paediatric patients with prolactinomas. METHODS: In this single-centre retrospective analysis, clinical, biochemical, and radiological features of all paediatric patients with pituitary adenomas diagnosed between 2000 and 2016 were evaluated. RESULTS: Among 21 patients with pituitary adenomas, 12 patients with prolactinomas (median age 14...
February 16, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29439093/dysregulated-genes-and-their-functional-pathways-in-luteinized-granulosa-cells-from-pcos-patients-after-cabergoline-treatment
#12
Hortensia Ferrero, Patricia Diaz-Gimeno, Patricia Sebastian-Leon, Amparo Faus, Raul Gómez, Antonio Pellicer
Polycystic ovarian syndrome (PCOS) is a common reproductive disorder frequently associated with a substantial risk factor for ovarian hyperstimulation syndrome (OHSS). Dopamine receptor 2 (D2) agonists, like Cabergoline (Cb2), have been used to reduce the OHSS risk. However, lutein granulosa cells (LGCs) from PCOS patients treated with Cb2 still show a deregulated dopaminergic tone (decreased D2 expression and low dopamine production) and increased vascularization compared to non-PCOS LGCs. Therefore, to understand the PCOS ovarian physiology, it is important to explore the mechanisms that underlie syndrome based on the therapeutic effects of Cb2...
February 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29428407/subclinical-haemorrhage-in-non-functional-adenomas
#13
H Cebula, E Fasciglione, M D N Santin, J Todeschi, F Severac, F Proust, J-L Dietemann, B Goichot
AIM: The prevalence and risk factors of subclinical haemorrhage on non-functional adenomas (NFA) remain controversial. The primary aim of our study was to assess the incidence of subclinical haemorrhage (SH) and the secondary objectives were to evaluate the risk factors of SH and the impact of SH on pituitary function at diagnosis. PATIENTS AND METHODS: This retrospective transversal analysis included 95 patients between January 2012 and December 2014. The patients included in this series were all adults (>18 years of age), who presented a non-functional adenoma confirmed by an endocrinological evaluation and on dedicated MRI pituitary imaging...
February 7, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29421446/transnasal-transphenoidal-elevation-of-optic-chiasm-in-secondary-empty-sella-syndrome-following-prolactinoma-treatment
#14
Mary In-Ping Huang Cobb, Rachael Mintz-Cole, Aatif M Husain, Miles Berger, David Jang, Patrick Codd
BACKGROUND: Prolactinomas are typically treated non-surgically with a dopamine agonist. However, once the tumor shrinks, adjacent eloquent structures such as the optic apparatus can become skeletonized and herniate into the dilated parasellar space. CASE DESCRIPTION: We describe here a 48-year-old man with a prolactin-secreting macroadenoma treated with cabergoline who presented with progressive bitemporal hemianopsia. MRI showed no recurrence of disease and a stretched optic chiasm herniating into an empty sella...
February 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29386731/severe-ovarian-hyperstimulation-syndrome-can-we-eliminate-it-through-a-multipronged-approach
#15
Nikita Naredi, S K Singh, Prasad Lele, N Nagraj
Background: Prevention of severe Ovarian Hyperstimulation Syndrome (OHSS), a potentially fatal complication of controlled ovarian hyperstimulation has been the aim of all fertility experts. Various pharmacologic and non-pharmacologic interventions have been instituted but the results have been conflicting. These preventive strategies were administered in isolation or as a combination of few aiming to eliminate this iatrogenic sequel. This study aimed to eliminate severe OHSS by multipronged approach incorporating almost all preventive modalities available in patients at high risk for this dreadful complication...
January 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29380701/the-expression-of-dopamine-receptors-gene-and-their-potential-role-in-targeting-breast-cancer-cells-with-selective-agonist-and-antagonist-drugs-could-it-be-the-novel-insight-to-therapy
#16
Hossein Bakhtou, Asiie Olfatbakhsh, Abdolkhaegh Deezagi, Ghasem Ahangari
BACKGROUND: Breast cancer is one of the common causes of mortality for women in Iran and other parts of the world. The substantial increasing rate of breast cancer in both developed and developing countries warns the scientists to provide more preventive steps and therapeutic measures. This study is conducted to investigate the impact of neurotransmitters (e.g., Dopamine) through their receptors and the importance of cancers via damaging immune system. It also evaluates dopamine receptors gene expression in the women with breast cancer at stages II or III and dopamine receptor D2 (DRD2) related agonist and antagonist drug effects on human breast cancer cells, including MCF-7 and SKBR-3...
January 29, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29378345/ectopic-prolactinoma-presenting-as-bacterial-meningitis-a-diagnostic-conundrum
#17
Oluwaseun O Akinduro
INTRODUCTION: Prolactinomas may rarely present with meningitis and cerebrospinal fluid (CSF) rhinorrhea secondary to erosion of the wall of the sella turcica. It is even more un-common for this abnormal communication to be caused by an ectopic prolactinoma arising from the sphenoid sinus and eroding into the sella. This atypical growth pattern makes diagnosis very difficult, as there may be no displacement of the normal pituitary gland. The authors present the first reported case of a patient with an ectopic prolactinoma presenting primarily with meningitis, and discuss the management strategy as well as surgical and non-surgical treatment options for these patients...
January 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29369737/pharmacology-of-serotonin-receptors-causing-contraction-of-isolated-bovine-posterior-ciliary-arteries-role-in-ocular-blood-flow
#18
Ya Fatou Njie-Mbye, Jenaye Robinson, Leah Mitchell-Bush, Marshalyn Mckoy, Catherine A Opere, Sunny E Ohia, Naj Sharif
PURPOSE: To determine the serotonergic (5HT) receptor subtype mediating the contraction of bovine posterior ciliary arteries (BPCAs) in vitro. METHODS: Longitudinal isometric tension was measured in BPCA strips (4-5 mm) mounted in 25 mL organ baths containing oxygenated Krebs solution at 37°C. Cumulative contractile concentration-response (C-R) curves were generated for various 5-HT agonists to assess their potencies and maximal degrees of contraction. Multiple agonist C-R curves were also constructed in the presence and absence of receptor-selective antagonists to determine antagonist potencies using Schild plots...
January 25, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29369118/administration-of-cabergoline-contributes-to-preserving-fertility-in-young-hyperprolactinemic-patients-with-endometrial-cancer-treated-with-medroxyprogesterone-acetate
#19
Chimeddulam Erdenebaatar, Munekage Yamaguchi, Fumitaka Saito, Mahina Monsur, Ritsuo Honda, Hironori Tashiro, Takashi Ohba, Hidetaka Katabuchi
BACKGROUND: An association between high levels of serum prolactin and endometrial cancer (EC) has been reported. However, the effect of antiprolactin drugs on hyperprolactinemic patients with EC has not been determined. The aim of this study was to confirm the effect of cabergoline on young hyperprolactinemic patients treated with medroxyprogesterone acetate (MPA) for the preservation of fertility. METHODS: A retrospective observational study was conducted to identify patients with atypical endometrial hyperplasia or early-stage EC aged 40 years or younger who were treated with oral MPA in Kumamoto University Hospital between 1998 and 2016...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29361932/efficacy-of-combined-treatment-with-pasireotide-pegvisomant-and-cabergoline-in-an-acromegalic-patient-resistant-to-other-treatments-a-case-report
#20
A Ciresi, S Radellini, V Guarnotta, C Giordano
BACKGROUND: The approach to acromegalic patients with persistent acromegaly after surgery and inadequate response to first-generation somatostatin receptor ligands (SRLs) should be strictly tailored. Current options include new pituitary surgery and/or radiosurgery, or alternative medical treatment with SRLs high dose regimens, pegvisomant (PEG) as monotherapy, or combined therapy with the addition of PEG or cabergoline to SRLs. A new pharmacological approach includes pasireotide, a second-generation SRL approved for patients who do not adequately respond to surgery and/or for whom surgery is not an option...
January 24, 2018: BMC Endocrine Disorders
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