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https://www.readbyqxmd.com/read/28525543/fermentable-carbohydrates-fodmaps-exacerbate-functional-gastrointestinal-symptoms-in-patients-with-inflammatory-bowel-disease-a-randomised-double-blind-placebo-controlled-cross-over-re-challenge-trial
#1
Selina R Cox, Alexis C Prince, Clio E Myers, Peter M Irving, James O Lindsay, Miranda C Lomer, Kevin Whelan
Background and Aims: Preliminary evidence suggests fermentable carbohydrate restriction might ameliorate functional gastrointestinal symptoms (FGS) in quiescent inflammatory bowel disease (IBD). Our aim was to determine whether fermentable carbohydrates exacerbate FGS in quiescent IBD using a randomised, double-blinded, placebo-controlled, cross-over, re-challenge trial. Methods: Patients with quiescent IBD and FGS responsive to a low FODMAP diet were allocated to a series of 3-day fermentable carbohydrate challenges in random order (fructan, 12 g/d; galacto-oligosaccharides, GOS, 6 g/d; sorbitol, 6 g/d; and glucose placebo, 12 g/d), each separated by a standardised washout period...
May 19, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28462704/the-role-of-dietary-approach-in-irritable-bowel-syndrome
#2
Piero Portincasa, Antony Lembo, Ornella De Bari, Domenica M Di Palo, Anna Maggio, Ilaria Cataldo, Giuseppe Calamita
Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract and is one of the most frequent gastrointestinal diseases. In IBS multiple pathophysiological mechanisms including alterations in intestinal motility, permeability, nutrient absorption, and intestinal microbiota have been implicated. Foods are commonly reported by patients to be a trigger of symptoms and therefore are likely involved in the generation of symptoms in IBS. Among all possible therapeutic options, a first-line approach to IBS is dietary education and identification of foods potentially responsible for the onset or worsening of symptoms...
April 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28445436/irritable-bowel-syndrome-clinical-manifestations-dietary-influences-and-management
#3
REVIEW
Ronald Ikechi, Bradford D Fischer, Joshua DeSipio, Sangita Phadtare
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by symptoms of chronic abdominal pain and altered bowel habits in the absence of an overtly identifiable cause. It is the most commonly diagnosed functional gastrointestinal disorder, accounting for about one third of gastroenterology visits. It generally presents as a complex of symptoms, including psychological dysfunction. Hypersensitivity to certain foods, especially foods that contain high amounts of fructose, plays a role in the pathophysiology of IBS...
April 26, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28440580/systematic-review-quality-of-trials-on-the-symptomatic-effects-of-the-low-fodmap-diet-for-irritable-bowel-syndrome
#4
REVIEW
L R Krogsgaard, M Lyngesen, P Bytzer
BACKGROUND: The low Fermentable Oligo-, Di- Monosaccharides, and Polyoles (FODMAP) diet is a new treatment option for irritable bowel syndrome (IBS). Experts refer to the diet as supported by high level of evidence, but an evaluation of the quality of trials is lacking. AIM: To provide a systematic review of the quality of trials on the symptomatic effects of the low FODMAP diet for IBS. METHODS: Pubmed and EMBASE were searched for randomised controlled trials (RCTs) reporting effect of the low FODMAP diet on IBS symptoms...
April 25, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28420945/controversies-and-recent-developments-of-the-low-fodmap-diet
#5
Peta Hill, Jane G Muir, Peter R Gibson
The low-fermentable oligo-, di-, and monosaccharide and polyol (FODMAP) diet is a 2-phased intervention, with strict reduction of all slowly absorbed or indigestible short-chain carbohydrates (ie, FODMAPs) followed by reintroduction of specific FODMAPs according to tolerance. The efficacy of the elimination phase of the FODMAP diet is well established, but the success of maintaining this diet has been shown in only a few observational studies. How the efficacy of the low-FODMAP diet compares with that of other therapies has received limited attention, but recent studies have shown this diet to be comparable or superior to diets that address eating style and choice of food as well as to gut hypnotherapy...
January 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28416515/multivariate-modelling-of-faecal-bacterial-profiles-of-patients-with-ibs-predicts-responsiveness-to-a-diet-low-in-fodmaps
#6
Sean M P Bennet, Lena Böhn, Stine Störsrud, Therese Liljebo, Lena Collin, Perjohan Lindfors, Hans Törnblom, Lena Öhman, Magnus Simrén
OBJECTIVE: The effects of dietary interventions on gut bacteria are ambiguous. Following a previous intervention study, we aimed to determine how differing diets impact gut bacteria and if bacterial profiles predict intervention response. DESIGN: Sixty-seven patients with IBS were randomised to traditional IBS (n=34) or low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) (n=33) diets for 4 weeks. Food intake was recorded for 4 days during screening and intervention...
April 17, 2017: Gut
https://www.readbyqxmd.com/read/28381835/low-fodmap-dietary-food-lists-are-often-discordant
#7
Ann R McMeans, Kristi L King, Bruno P Chumpitazi
No abstract text is available yet for this article.
April 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28370046/editorial-rethinking-predictors-of-response-to-the-low-fodmap-diet-should-we-retire-fructose-and-lactose-breath-hydrogen-testing-and-concentrate-on-visceral-hypersensitivity-authors-reply
#8
EDITORIAL
C H Wilder-Smith, S S Olesen, A Materna, A M Drewes
No abstract text is available yet for this article.
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28370043/editorial-rethinking-predictors-of-response-to-the-low-fodmap-diet-should-we-retire-fructose-and-lactose-breath-hydrogen-testing-and-concentrate-on-visceral-hypersensitivity
#9
EDITORIAL
C J Tuck, L S McNamara, P R Gibson
No abstract text is available yet for this article.
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28345807/low-fodmap-in-2017-lessons-learned-from-clinical-trials-and-mechanistic-studies
#10
REVIEW
S Eswaran
Given the prevalence of irritable bowel syndrome (IBS) and the suboptimal response to most therapeutic approaches, there has been increasing interest in and adoption of dietary treatment strategies, such as the low Fermentable Oligo-, Di-, & Mono-Saccharides and Polyols (FODMAP) diet. FODMAPs are a diverse group of carbohydrates that exert effects in the gastrointestinal tract not only via fermentation but likely via alterations in the microbiota, metabolome, permeability, and intestinal immunity as well. Clinical evidence for efficacy of this diet is mounting, but there are significant questions regarding short- and long-term safety and effects on the microbiota and nutrition that remain unanswered...
April 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28342683/white-grape-juice-elicits-a-lower-breath-hydrogen-response-compared-with-apple-juice-in-healthy-human-subjects-a-randomized-controlled-trial
#11
Jennifer Erickson, Qi Wang, Joanne Slavin
BACKGROUND: Diets low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPS) are used to manage symptoms in individuals with irritable bowel syndrome. Although effective at reducing symptoms, the diet can be complex and restrictive. In addition, there are still large gaps in the literature and many foods with unclear effects in the gastrointestinal (GI) tract, like fruit juice. Although many fruits are allowable on a low-FODMAP diet, consumption of all fruit juice is generally cautioned due to the large fructose load contained in juice, regardless of the glucose concentration...
March 22, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28334433/dietary-interventions-for-recurrent-abdominal-pain-in-childhood
#12
REVIEW
Tamsin V Newlove-Delgado, Alice E Martin, Rebecca A Abbott, Alison Bethel, Joanna Thompson-Coon, Rebecca Whear, Stuart Logan
BACKGROUND: This is an update of the original Cochrane review, last published in 2009 (Huertas-Ceballos 2009). Recurrent abdominal pain (RAP), including children with irritable bowel syndrome, is a common problem affecting between 4% and 25% of school-aged children. For the majority of such children, no organic cause for their pain can be found on physical examination or investigation. Many dietary inventions have been suggested to improve the symptoms of RAP. These may involve either excluding ingredients from the diet or adding supplements such as fibre or probiotics...
March 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28303579/endometriosis-in-patients-with-irritable-bowel-syndrome-specific-symptomatic-and-demographic-profile-and-response-to-the-low-fodmap-diet
#13
Judith S Moore, Peter R Gibson, Richard E Perry, Rebecca E Burgell
BACKGROUND: Women with endometriosis are frequently misdiagnosed with irritable bowel syndrome (IBS) for some time before a correct diagnosis is made. Visceral hypersensitivity is a key feature in both conditions. AIMS: To determine if there are distinct symptom patterns in women with IBS and endometriosis, and to determine the response of these women to a low FODMAP diet in comparison to those with IBS alone. MATERIALS AND METHODS: A retrospective analysis of prospectively collected data from women attending a specialist IBS service in Christchurch New Zealand...
March 17, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28300773/the-low-fodmap-diet-many-question-marks-for-a-catchy-acronym
#14
REVIEW
Giulia Catassi, Elena Lionetti, Simona Gatti, Carlo Catassi
FODMAP, "Fermentable Oligo-, Di- and Mono-saccharides And Polyols", is a heterogeneous group of highly fermentable but poorly absorbed short-chain carbohydrates and polyols. Dietary FODMAPs might exacerbate intestinal symptoms by increasing small intestinal water volume, colonic gas production, and intestinal motility. In recent years the low-FODMAP diet for treatment of irritable bowel syndrome (IBS) has gained increasing popularity. In the present review we aim to summarize the physiological, clinical, and nutritional issues, suggesting caution in the prolonged use of this dietary treatment on the basis of the existing literature...
March 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28244679/use-of-the-low-fodmap-diet-in-inflammatory-bowel-disease
#15
REVIEW
Peter R Gibson
Irritable bowel syndrome (IBS)-like symptoms are not uncommon in patients with quiescent inflammatory bowel disease (IBD). While gluten-free diet is applied by patients, there are no reported interventional studies. The low-FODMAP diet, on the other hand, has efficacy similar to that seen in patients with IBS in three unblinded or observational studies of IBD cohorts who had well-controlled inflammatory disease and in one small randomized cross-over study. FODMAP intake by patients with IBD is not elevated, and, in one study, fructan intakes were lower in patients with Crohn's disease than in controls...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28244677/using-ehealth-strategies-in-delivering-dietary-and-other-therapies-in-patients-with-irritable-bowel-syndrome-and-inflammatory-bowel-disease
#16
REVIEW
Dorit Vedel Ankersen, Katrine Carlsen, Dorte Marker, Pia Munkholm, Johan Burisch
Health-care systems around the world are facing increasing costs. Non-adherent, chronically ill patients are one such expense incurred by health-care providers. Web-based home-monitoring of patients-or eHealth-has been shown to increase adherence to medical therapy, facilitate contact between patients and health-care professionals, and reduce time to remission for patients with inflammatory bowel disease (IBD). Web-based treatment is a supportive tool for the health-care provider in an out-patient clinic. eHealth web-programs, such as the Constant Care application, visualize disease activity in a traffic light system and empower patients to screen for disease activity, enabling them to respond appropriately to their symptoms...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28244675/the-clinical-value-of-breath-hydrogen-testing
#17
REVIEW
Chu K Yao, Caroline J Tuck
Breath hydrogen testing for assessing the presence of carbohydrate malabsorption is frequently applied to refine dietary restrictions on a low fermentable carbohydrate (FODMAP) diet. Its application has also been extended for the detection of small intestinal bacterial overgrowth. Recently, several caveats of its methodology and interpretation have emerged. A review of the evidence surrounding its application in the management of patients with a functional bowel disorder was performed. Studies were examined to assess limitations of testing methodology, interpretation of results, reproducibility, and how this relates to clinical symptoms...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28244674/adapting-the-low-fodmap-diet-to-special-populations-infants-and-children
#18
REVIEW
Marina Iacovou
Management of gut-related symptoms in the pediatric population can be challenging. Many factors need to be taken into consideration including psychological, behavioral, social and family environments, and growth and developmental requirements. This review focuses on two issues: potential dietary therapies that are thought to relieve the symptoms of infantile colic, a condition that is believed to be gastrointestinal in nature; and the evidence and dietary considerations surrounding children with irritable bowel syndrome...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28244673/history-of-the-low-fodmap-diet
#19
REVIEW
Peter R Gibson
It has long been known that many short-chain carbohydrates can induce abdominal symptoms that are similar to those in patients with irritable bowel syndrome (IBS). It was hypothesized that restricting the intake of all short-chain carbohydrates that are either slowly absorbed or not digested in the small intestine should be considered together because they all have similar effects on the intestine by distending the lumen. These groups of carbohydrates were called, Fermentable, Oligosaccharides, Disaccharides and Monosaccharides and Polyols (FODMAPs), because of the lack of a known collective term...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28244671/prebiotic-inulin-type-fructans-and-galacto-oligosaccharides-definition-specificity-function-and-application-in-gastrointestinal-disorders
#20
REVIEW
Bridgette Wilson, Kevin Whelan
Prebiotics are non-digestible selectively fermented dietary fibers that specifically promote the growth of one or more bacterial genera in the gastrointestinal tract and thus provide health benefit to the host. The two most investigated prebiotics being the inulin-type fructans and galacto-oligosaccharides. Prebiotic specificity is mediated through species-specific gene clusters within saccharolytic bacteria controlled by signaling sensors for various substrates. Prebiotic health benefits are attributed to immune regulation and bacterial metabolite production...
March 2017: Journal of Gastroenterology and Hepatology
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