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https://www.readbyqxmd.com/read/29671672/pathophysiological-effect-of-bladder-outlet-obstruction-on-the-urothelium
#1
Grzegorz Niemczyk, Katarzyna Czarzasta, Piotr Radziszewski, Paweł Włodarski, Agnieszka Cudnoch-Jędrzejewska
Bladder outlet obstruction (BOO) and associated lower urinary tract symptoms are major urological issues that significantly affect patient's quality of life and may lead to severe complications. The prevalence of both is increasing each year, raising the burden to health system. Therefore, casual and symptomatic treatment should be of great importance. However, management of symptoms is often difficult as their pathophysiology is multifactorial and not well elucidated. Recently urothelium has gathered much attention as one of the potential causal agents...
April 19, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29667065/single-site-laparoscopy-and-robotic-surgery-in-pediatric-urology
#2
REVIEW
Diana K Bowen, Jason P Van Batavia, Arun K Srinivasan
PURPOSE OF REVIEW: In this review, we summarize research that has evaluated the role of laparoendoscopic single-site (LESS) and robotic surgery in pediatric urology, highlighting new and/or controversial ideas. RECENT FINDINGS: The newest research developments over the last several years are studies that address generalizability of these techniques, ideal patient factors, extrapolation to more complex surgeries, and comparative studies to more traditional techniques to define the associated costs and benefits, as well as patient-centered outcomes...
April 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29666837/cancer-telomeres-and-white-crows
#3
REVIEW
Alan K Meeker
This mini-review article discusses past and present prostate-focused research on telomere and telomerase biology conducted at Johns Hopkins, through the eyes of a Donald S Coffey trainee. Included are past discoveries of abnormalities in telomere biology in the context of prostate cancer and its pre-malignant precursor prostatic intraepithelial neoplasia (PIN); the finding that telomerase activity is androgen-regulated in the prostate, and the potential role of telomerase in prostate epithelial stem cells. Also reviewed are more recent results showing that in situ telomere length measurements in patient tissue specimens may have utility in risk assessment and as a prognostic biomarker...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666835/aptamers-and-apple-pies-a-mini-review-of-psma-aptamers-and-lessons-from-donald-s-coffey
#4
REVIEW
Shawn E Lupold
This mini-review article is part of a special issue dedicated to Donald S. Coffey, a pioneer translational research scientist, exemplary mentor, and leader in urologic and urologic oncology research. This article first briefly reflects on life and scientific lessons from Don Coffey. It then reviews the development of two prostate cancer targeting RNA aptamers, xPSM-A9 and xPSM-A10, through in vitro selection for aptamers that bind to the extracellular domain of the Prostate Specific Membrane Antigen (PSMA)...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666747/symphysis-pubis-osteomyelitis-an-uncommon-complication-after-robotic-assisted-radical-prostatectomy-case-description-with-literature-review
#5
Jad A Degheili, Mazen M Mansour, Rami W Nasr
Prostate cancer is the most common solid cancer among American men. Although there are various modalities for treatment, including radical prostatectomy among many others, the former is, nevertheless, not without any accompanied complications. Other than the well-known surgical complications such as erectile dysfunction, urinary incontinence, and voiding dysfunction, osteomyelitis of the symphysis pubis is not a well-understood complication, with various hypotheses explaining its pathogenesis. Although osteomyelitis of the pubis symphysis has been reported after endoscopic urological procedures such as transurethral resection of the prostate, it has rarely been reported after robotic surgeries...
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29662543/optical-improvements-in-the-diagnosis-of-bladder-cancer-implications-for-clinical-practice
#6
REVIEW
Tina Schubert, Steffen Rausch, Omar Fahmy, Georgios Gakis, Arnulf Stenzl
Background: For over 100 years white-light cystoscopy has remained the gold-standard technique for the detection of bladder cancer (BCa). Some limitations in the detection of flat lesions (CIS), the differentiation between inflammation and malignancy, the inaccurate determination of the tumor margin status as well as the tumor depth, have led to a variety of technological improvements. The aim of this review is to evaluate the impact of these improvements in the diagnosis of BCa and their effectiveness in clinical practice...
November 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29662542/meta-analysis-of-studies-comparing-oncologic-outcomes-of-radical-prostatectomy-and-brachytherapy-for-localized-prostate-cancer
#7
Gabriele Cozzi, Gennaro Musi, Roberto Bianchi, Danilo Bottero, Antonio Brescia, Antonio Cioffi, Giovanni Cordima, Maurizio Delor, Ettore Di Trapani, Matteo Ferro, Deliu Victor Matei, Andrea Russo, Francesco Alessandro Mistretta, Ottavio De Cobelli
Background: The aim of this study was to compare oncologic outcomes of radical prostatectomy (RP) with brachytherapy (BT). Methods: A literature review was conducted according to the 'Preferred reporting items for systematic reviews and meta-analyses' (PRISMA) statement. We included studies reporting comparative oncologic outcomes of RP versus BT for localized prostate cancer (PCa). From each comparative study, we extracted the study design, the number and features of the included patients, and the oncologic outcomes expressed as all-cause mortality (ACM), PCa-specific mortality (PCSM) or, when the former were unavailable, as biochemical recurrence (BCR)...
November 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29661588/impact-of-metabolic-diseases-drugs-and-dietary-factors-on-prostate-cancer-risk-recurrence-and-survival-a-systematic-review-by-the-european-association-of-urology-section-of-oncological-urology
#8
REVIEW
Riccardo Campi, Sabine D Brookman-May, Jose Daniel Subiela Henríquez, Bülent Akdoğan, Maurizio Brausi, Tobias Klatte, Johan F Langenhuijsen, Estefania Linares-Espinos, Martin Marszalek, Morgan Roupret, Christian G Stief, Alessandro Volpe, Andrea Minervini, Oscar Rodriguez-Faba
CONTEXT: To date, established risk factors for prostate cancer (PCa) are limited to age, race, family history, and certain genetic polymorphisms. Despite great research efforts, available evidence on potentially modifiable risk factors is conflicting. Moreover, most studies on PCa risk factors did not consider the impact of prostate-specific antigen (PSA) testing on PCa diagnosis. OBJECTIVE: To provide a detailed overview of the latest evidence on the role of metabolic diseases, drugs, and dietary factors for risk of PCa incidence, recurrence, and survival in men exposed to PSA testing...
April 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29658681/laparoscopic-radical-prostatectomy-in-2018-20-years-of-worldwide-experiences-experimentations-researches-and-refinements
#9
Aldo Brassetti, Renaud Bollens
INTRODUCTION: After the first feasibility report in 1997, a growing interest has risen in the urologic community for laparoscopic radical prostatectomy (LRP) and several authors have contributed to the evolution of the technique. We attempt a review of the available evidences and provide a broad framework of different technical refinements considering their impact on pentafecta. EVIDENCE ACQUISITION: The PubMed/Medline database was searched. Duplicates and "Expert opinion" papers were removed...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29658322/clinical-effectiveness-and-versatility-of-a-sealing-hemostatic-patch-hemopatch-in-multiple-surgical-specialties
#10
Kevin M Lewis, Shelly Ikeme, Tolu Olubunmi, Carl Erik Kuntze
Intraoperative surgical sealants and hemostatic agents have been shown to reduce postoperative complications, transfusions and hospital resource utilization. Despite availability of these agents, the incidence and burden of bleeding remains high and surgeons' requirements for hemostatic control continue to evolve. A burgeoning class of hemostatic agents are hemostatic patches, which offer package-to-patient readiness and direct application. In addition, hemostatic patches may provide tissue sealing capabilities...
April 16, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29653162/inconsistency-in-the-definition-of-urinary-tract-infection-after-intravesical-botulinum-toxin-a-injection-a-systematic-review
#11
Andrew W Stamm, Sarah A Adelstein, Andrew Chen, Alvaro Lucioni, Kathleen C Kobashi, Una J Lee
PURPOSE: In order to more accurately examine the rate of urinary tract infection following onabotulinumtoxinA injection of the bladder, we systematically reviewed the literature for definitions of urinary tract infection utilized in series that reported on onabotulinumtoxinA injections and assessed them for consistency with guideline statements defining urinary tract infections. MATERIALS AND METHODS: A systematic review of the literature was performed via query using MEDLINE and EMBASE...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29650821/-continuation-of-axitinib-for-advanced-renal-cell-carcinoma-by-the-application-of-homecare-urology-a-case-report-and-literature-review
#12
Satoshi Yazawa, Yuji Kato, Jin Nakahara, Toshio Miyata, Mototsugu Oya
A 56-year-old man with advanced RCC and a past medical history of type 2 diabetes underwent a radical left nephrectomy following a histological diagnosis of papillary RCC, G2, INF b, pT3, V1 in 1999. In 2008, sorafenib was started to treat multiple pulmonary metastases of RCC. In 2011, sorafenib was switched to sunitinib when radiologic progression was observed. In 2014, sunitinib was switched to axitinib when further radiologic progression was observed. In 2015, the patient was referred to Yazawa clinic for homecare urology when hospital visits became difficult due to cancer pain and bilateral lower-extremity muscle weakness...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650457/-non-palpable-testicular-tumors-in-adults-a-management-based-on-imaging-issue-from-the-french-urologic-association-genital-cancer-committee-s-edit
#13
L Rocher, L Feretti, P Camparo, P H Savoie, N Morel-Journel, T Murez, P Sebe, A Flechon, A Méjean, X Durand
BACKGROUND: Help in management of non-palpable testicular tumors. French Urologic Association Genital cancer committee's Edit. OBJECTIVES: To review their characterization at imaging findings of non-palpable testicular tumors. DOCUMENTARY SOURCES: Literature review (PubMed, Medline) of urological and radiological studies dealing with testicular tumors using keywords: non-palpable/incidental testicular tumors; color Doppler ultrasound; US elastography; magnetic resonance imaging; contrast enhanced sonography; partial surgery...
April 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29649079/in-search-of-mobile-applications-for-urogynecology-providers
#14
Shannon L Wallace, Shailja Mehta, Sara Farag, Robert S Kelley, Katherine T Chen
INTRODUCTION: Thousands of medical applications (apps) are available for mobile devices. Finding accurate, health care provider-centered apps may be time consuming and frustrating for urogynecologists. The objective of this study was to identify and evaluate urogynecology (urogyn) apps using a modified APPLICATIONS scoring system. MATERIALS AND METHODS: Urogyn apps were identified from the Apple iTunes and Google Play Stores using the following 10 MeSH terms: urogynecology, incontinence, prolapse, urinary tract infection, pelvic surgery, fecal incontinence, defecation disorder, voiding disorder, urethral diverticulum, and fistula...
April 11, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29644169/testosterone-replacement-therapy-for-physician-assistants-and-nurse-practitioners
#15
REVIEW
Libert Ramos, Amir Shahreza Patel, Ranjith Ramasamy
Physician assistants (PA) and nurse practitioners have been moving toward specialty practices, like urology. With increased training and education, they manage more complex conditions independently. Whether they are the primary provider or the follow up to a specialist, physician extenders can play a vital role in managing patients undergoing testosterone therapy. Physician extenders should be able to understand the indications, risks and associated adverse effects of administering testosterone in order to proficiently take care of patients with low testosterone...
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29644168/pelvic-fracture-urethral-injury-in-males-mechanisms-of-injury-management-options-and-outcomes
#16
REVIEW
Rachel C Barratt, Jason Bernard, Anthony R Mundy, Tamsin J Greenwell
Pelvic fracture urethral injury (PFUI) management in male adults and children is controversial. The jury is still out on the best way to manage these injuries in the short and long-term to minimise complications and optimise outcomes. There is also little in the urological literature about pelvic fractures themselves, their causes, grading systems, associated injuries and the mechanism of PFUI. A review of pelvic fracture and male PFUI literature since 1757 was performed to determine pelvic fracture classification, associated injuries and, PFUI classification and management...
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29642316/re-medical-treatment-of-nocturia-in-men-with-lower-urinary-tract-symptoms-systematic-review-by-the-european-association-of-urology-guidelines-panel-for-male-lower-urinary-tract-symptoms
#17
https://www.readbyqxmd.com/read/29629860/publish-and-perish-a-urological-perspective-on-predatory-publications
#18
Michael Di Lena, J Curtis Nickel
INTRODUCTION: It is an accepted axiom that academics must publish to be considered successful. Open-source journals are quickly gaining traction in the scientific community as an effective way to disseminate important research. The open-access movement includes many successful, well-respected operations, but has also spawned a plethora of journals, some predatory and others that appear to be amateurish academic traps. We provide a first look at open-source journals, both reputable and predatory, specifically pertaining to urology...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29627196/non-molecular-methods-to-detect-bacteriuria-prior-to-urological-interventions-a-diagnostic-accuracy-systematic-review
#19
Gernot Bonkat, Olivier Braissant, Tomasso Cai, Bela Köves, Truls E Bjerklund Johansen, Robert Pickard, Rajan Veeratterapillay
Urine culture still has to be considered as the gold standard to rule out bacteriuria and should, therefore, be obtained prior to invasive endoscopic or open urological procedures to minimize the risk of severe infectious complications.
April 4, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29626570/-what-is-the-role-of-alpha-blockers-for-medical-expulsive-therapy-results-from-a-meta-analysis-of-60-randomised-trials-and-over-9500-patients
#20
REVIEW
Omar M Aboumarzouk, Patrick Jones, Tarik Amer, Dimitris Kotsiris, Esteban Emiliani, Bhaskar Somani, Panagiotis Kallidonis, Thomas Tailly, Gohkan Atis, Francesco Greco, Stephan Hruby, Mario Alvarez, Khalid Al-Rumaihi, Ahmed Shamsuddin, Abdulla Al-Ansari, Ahmed Shokeir
Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in Urology. Moreover, there have been a number of randomised controlled trials (RCTs) with differing results. We conducted a systematic review and meta-analysis of RCTs investigating the efficacy α-blockers for MET. This review confirms there is a role for α-blockers in medical expulsive therapy for ureteric stones specifically in stones >5mm and distal ureteric stones, which is associated with improved stone expulsion...
April 4, 2018: Urology
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