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https://www.readbyqxmd.com/read/29331379/effect-of-histidine-on-sorafenib-induced-vascular-damage-analysis-using-novel-medaka-fish-model
#1
Yoko Shinagawa-Kobayashi, Kenya Kamimura, Ryo Goto, Kohei Ogawa, Ryosuke Inoue, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Soichi Sugitani, Masahiko Yanagi, Koichi Fujisawa, Yoshizu Nozawa, Naoto Koyama, Hiroshi Nishina, Makoto Furutani-Seiki, Isao Sakaida, Shuji Terai
BACKGROUND: Sorafenib (SFN) is an anti-angiogenic chemotherapeutic that prolongs survival of patients with hepatocellular carcinoma (HCC); its side effects, including vascular damages such as hand-foot syndrome (HFS), are a major cause of therapy discontinuation. We previously reported that maintenance of peripheral blood flow by intake of dried bonito broth (DBB) significantly prevented HFS and prolonged the administration period. The amino acids contained in DBB probably contribute to its effects, but the mechanism has not been clarified...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29322369/proteomic-and-metabolomic-analysis-of-marine-medaka-oryzias-melastigma-after-acute-ammonia-exposure
#2
Limei Zhu, Na Gao, Ruifang Wang, Li Zhang
Ammonia is both a highly toxic environmental pollutant and the major nitrogenous waste produced by ammoniotelic teleosts. Although the acute toxic effects of ammonia have been widely studied in fish, the biochemical mechanisms of its toxicity have not been understood comprehensively. In this study, we performed comparative proteomic and metabolomic analysis between ammonia-challenged (1.2 and 2.6 mmol L-1 NH4Cl for 96 h) and control groups of marine medaka (Oryzias melastigma) to identify changes of the metabolite and protein profiles in response to ammonia stress...
January 10, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29316906/the-function-of-tcf3-in-medaka-embryos-efficient-knockdown-with-pepnas
#3
Gerlinde Doenz, Sebastian Dorn, Narges Aghaallaei, Baubak Bajoghli, Elisabeth Riegel, Michaela Aigner, Holger Bock, Birgit Werner, Thomas Lindhorst, Thomas Czerny
BACKGROUND: The application of antisense molecules, such as morpholino oligonucleotides, is an efficient method of gene inactivation in vivo. We recently introduced phosphonic ester modified peptide nucleic acids (PNA) for in vivo loss-of-function experiments in medaka embryos. Here we tested novel modifications of the PNA backbone to knockdown the medaka tcf3 gene. RESULTS: A single tcf3 gene exists in the medaka genome and its inactivation strongly affected eye development of the embryos, leading to size reduction and anophthalmia in severe cases...
January 9, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29307115/bioinformatic-analyses-of-zona-pellucida-genes-in-vertebrates-and-their-expression-in-nile-tilapia
#4
Tianli Wu, Yunying Cheng, Zhilong Liu, Wenjing Tao, Shuqing Zheng, Deshou Wang
Zona pellucida (ZP) genes encode ZP glycoproteins which constitute the coat surrounding oocytes and early embryos. Genome-wide identification of ZP genes is still lacking in vertebrates, especially in fish species. Herein, we conducted bioinformatic analyses of the ZP genes of the Nile tilapia and other vertebrates. Totally 16, 9, 17, 27, 21, 20, 26, 19, 14,11, 24, 17, 9, 18, 8, 11, 9, 8, 5, and 4 ZP genes belonging to 5 subfamilies (ZPA, ZPB, ZPC, ZPD, and ZPAX) were found in the sea lamprey, elephant shark, coelacanth, spotted gar, zebrafish, medaka, stickleback, Nile tilapia, Amazon molly, platyfish, seahorse, Northern snakehead, cavefish, tetraodon, clawed frog, turtle, chicken, platypus, kangaroo rat, and human genomes, respectively...
January 6, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29306823/sensitivity-of-medaka-oryzias-latipes-to-4-nonylphenol-subacute-exposure-erythrocyte-alterations-and-apoptosis
#5
Alaa El-Din H Sayed, Chisato Kataoka, Shoji Oda, Shosaku Kashiwada, Hiroshi Mitani
The present study was undertaken to assess the effects of the endocrine-disrupting compound; 4-nonylphenol (4-NP) in medaka (Oryzias latipes). The frequencies of erythrocyte alterations, apoptosis, and micronuclei were used as biological indicators of damage. Medaka were exposed 15 days to 4-NP at three sublethal concentrations (50, 80, and 100 μg/l 4-NP) and results compared with those of a previous study using catfish as an animal model. Exposure of medaka resulted in a dose-dependent increase in the frequency of erythrocyte alterations, apoptosis and micronucleus (MN)...
December 26, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29305975/identification-and-expression-analysis-of-micrornas-in-medaka-gonads
#6
Weiwei Qiu, Yefei Zhu, Yun Wu, Cancan Yuan, Kerang Chen, Mingyou Li
Gonad development is a highly regulated, coordinated biological process and increasing evidences have indicated that microRNA (miRNA) may be involved in this dynamic program. Medaka (Oryzias latipes) is a good model for reproductive research as it has distinct sex determining genes, however, research in gonadal miRNAs is lacked. In this study, two small RNA libraries from the ovaries and testes were constructed and sequenced. A total of 285 conserved and 388 novel miRNAs were obtained, among which, 142 mature miRNAs were significantly (> two-fold change) up or down regulated in the testis compared to the ovary...
January 3, 2018: Gene
https://www.readbyqxmd.com/read/29300923/morphological-analysis-of-the-axonal-projections-of-egfp-labeled-esr1-expressing-neurons-in-transgenic-female-medaka
#7
Buntaro Zempo, Tomomi Karigo, Shinji Kanda, Yasuhisa Akazome, Yoshitaka Oka
Some hypothalamic neurons expressing estrogen receptor α (Esr1) are thought to transmit a gonadal estrogen feedback signal to gonadotropin releasing hormone 1 (GnRH1) neurons, which is the final common pathway for feedback regulation of reproductive functions. Moreover, estrogen-sensitive neurons are suggested to control sexual behaviors in coordination with reproduction. In mammals, hypothalamic estrogen-sensitive neurons release the peptide Kisspeptin and regulate GnRH1 neurons. However, a growing body of evidence in non-mammalian species casts doubt on the regulation of GnRH1 neurons by Kisspeptin neurons...
December 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29290830/constructing-a-chromonome-of-yellowtail-seriola-quinqueradiata-for-comparative-analysis-of-chromosomal-rearrangements
#8
Junya Kawase, Jun-Ya Aoki, Kazuo Araki
To investigate chromosome evolution in fish species, we newly mapped 181 markers that allowed us to construct a yellowtail (Seriola quinqueradiata) radiation hybrid (RH) physical map with 1,713 DNA markers, which was far denser than a previous map, and we anchored the de novo assembled sequences onto the RH physical map. Finally, we mapped a total of 13,977 expressed sequence tags (ESTs) on a genome sequence assembly aligned with the physical map. Using the high-density physical map and anchored genome sequences, we accurately compared the yellowtail genome structure with the genome structures of five model fishes to identify characteristics of the yellowtail genome...
2018: Journal of Genomics
https://www.readbyqxmd.com/read/29288672/seasonal-changes-in-color-perception
#9
REVIEW
Tsuyoshi Shimmura, Tomoya Nakayama, Ai Shinomiya, Takashi Yoshimura
In temperate zones, organisms experience dynamic fluctuations in environment including changes in color. To cope with such seasonal changes in the environment, organisms adapt their physiology and behavior. Although color perception has been believed to be fixed throughout life, there is increasing evidence for the alteration in opsin gene expression induced by environmental stimuli in a number of animals. Very recently, dynamic seasonal plasticity in color perception has been reported in the seasonally breeding medaka fish...
December 27, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29280155/nanosecond-pulsed-electric-field-incorporation-technique-to-predict-molecular-mechanisms-of-teratogenicity-and-developmental-toxicity-of-estradiol-17%C3%AE-on-medaka-embryos
#10
Akemi Yamaguchi, Hiroshi Ishibashi, Susumu Kono, Midori Iida, Masaya Uchida, Koji Arizono, Nobuaki Tominaga
Herein, we propose using a nanosecond pulsed electric field (nsPEF) technique to assess teratogenicity and embryonic developmental toxicity of estradiol-17β (E2 ) and predict the molecular mechanisms of teratogenicity and embryonic developmental defects caused by E2 on medaka (Oryzias latipes). The 5 hour post-fertilization embryos were exposed to co-treatment with 10 μm E2 and nsPEF for 2 hours and then continuously cultured under non-E2 and nsPEF conditions until hatching. Results documented that the time to hatching of embryos was significantly delayed in comparison to the control group and that typical abnormal embryo development, such as the delay of blood vessel formation, was observed...
December 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29276994/transcriptomic-analysis-reveals-transgenerational-effect-of-hypoxia-on-the-neural-control-of-testicular-functions
#11
Keng Po Lai, Jing Woei Li, Simon Yuan Wang, Miles Teng Wan, Ting Fung Chan, Wing Yee Lui, Doris Wai-Ting Au, Rudolf Shiu-Sun Wu, Richard Yuen-Chong Kong
There are over 400 hypoxic zones in the ocean worldwide. Both laboratory and field studies have shown that hypoxia causes endocrine disruption and reproductive impairments in vertebrates. More importantly, our recent study discovered that parental (F0) hypoxia exposure resulted in the transgenerational impairment of sperm quality in the F2 generation through the epigenetic regulation of germ cells. In the present study, we aim to test the hypothesis that the brain, as the major regulator of the brain-pituitary-gonad (BPG) axis, is also involved in the observed transgenerational effect...
December 16, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29231924/the-mineralocorticoid-receptor-knockout-in-medaka-is-further-validated-by-glucocorticoid-receptor-compensation
#12
Tatsuya Sakamoto, Madoka Yoshiki, Hirotaka Sakamoto
To study the critical role of mineralocorticoid signalling, we generated a constitutive mineralocorticoid receptor (MR)-knockout (KO) medaka as the first adult-viable MR-KO animal. This KO medaka displayed abnormal behaviours affected by visual stimuli. In contrast, the loss of MR did not result in overt phenotypic changes in osmoregulation, despite the well-known osmoregulatory functions of MR in mammals. Since glucocorticoid receptor (GR) has been suggested to compensate for loss of MR, we examined expression of duplicated GRs with markedly different ligand sensitivities, in various tissues...
December 12, 2017: Scientific Data
https://www.readbyqxmd.com/read/29230594/molecular-evolution-of-myoglobin-in-the-tibetan-plateau-endemic-schizothoracine-fish-cyprinidae-teleostei-and-tissue-specific-expression-changes-under-hypoxia
#13
Delin Qi, Yan Chao, Yongli Zhao, Mingzhe Xia, Rongrong Wu
Myoglobin (Mb) is an oxygen-binding hemoprotein that was once thought to be exclusively expressed in oxidative myocytes of skeletal and cardiac muscle where it serves in oxygen storage and facilitates intracellular oxygen diffusion. In this study, we cloned the coding sequence of the Mb gene from four species, representing three groups, of the schizothoracine fish endemic to the Qinghai-Tibetan Plateau (QTP), then conducted molecular evolution analyses. We also investigated tissue expression patterns of Mb and the expression response to moderate and severe hypoxia at the mRNA and protein levels in a representative of the highly specialized schizothoracine fish species, Schizopygopsis pylzovi...
December 11, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29225074/the-effect-of-fish-gender-on-susceptibility-to-acute-streptococcus-agalactiae-infection-in-javanese-medaka-oryzias-javanicus
#14
M N A Amal, S T Zarif, M Suhaiba, M R M Aidil, N N Shaqinah, M Zamri-Saad, A Ismail
This study describes the susceptibility of different fish gender following acute Streptococcus agalactiae infection by using Javanese medaka Oryzias javanicus as test fish. The fish were grouped into four groups, which were: (1) all-male; (2) all-female; (3) mixed-gender (1 male: 1 female ratio); and (4) control non-infected (1 male: 1 female ratio). The fish in group 1, 2 and 3 were intraperitoneally exposed to 5.4 × 108 CFU/ml of S. agalactiae, while for group 4, the fish were exposed using sterile broth...
December 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29220784/physiological-effects-caused-by-microcystin-producing-and-non-microcystin-producing-microcystis-aeruginosa-on-medaka-fish-a%C3%A2-proteomic-and-metabolomic-study-on-liver
#15
Séverine Le Manach, Benoit Sotton, Hélène Huet, Charlotte Duval, Alain Paris, Arul Marie, Claude Yépremian, Arnaud Catherine, Lucrèce Mathéron, Joelle Vinh, Marc Edery, Benjamin Marie
Cyanobacterial blooms have become a common phenomenon in eutrophic freshwater ecosystems worldwide. Microcystis is an important bloom-forming and toxin-producing genus in continental aquatic ecosystems, which poses a potential risk to Human populations as well as on aquatic organisms. Microcystis is known to produce along with various bioactive peptides, the microcystins (MCs) that have attracted more attention notably due to their high hepatotoxicity. To better understand the effects of cyanobacterial blooms on fish, medaka fish (Oryzias latipes) were sub-chronically exposed to either non-MC-producing or MC-producing living strains and, for this latter, to its subsequent MC-extract of Microcystis aeruginosa...
December 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29217326/the-effect-of-fish-gender-on-susceptibility-to-acute-streptococcus-agalactiae-infection-in-javanese-medaka-oryzias-javanicus
#16
M N A Amal, S T Zarif, M Suhaiba, M R M Aidil, N N Shaqinah, M Zamri-Saad, A Ismail
This study describes the susceptibility of different fish gender following acute Streptococcus agalactiae infection by using Javanese medaka Oryzias javanicus as test fish. The fish were grouped into four groups, which were: (1) all-male; (2) all-female; (3) mixed-gender (1 male: 1 female ratio); and (4) control non-infected (1 male: 1 female ratio). The fish in group 1, 2 and 3 were intraperitoneally exposed to 5.4 × 108 CFU/ml of S. agalactiae, while for group 4, the fish were exposed using sterile broth...
December 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29211466/identification-of-unknown-antiandrogenic-compounds-in-surface-waters-by-effect-directed-analysis-eda-using-a-parallel-fractionation-approach
#17
Matthias Muschket, Carolina Di Paolo, Andrew J Tindall, Gerald Touak, Audrey Phan, Martin Krauss, Kristina Kirchner, Thomas Benjamin Seiler, Henner Hollert, Werner Brack
Among all the nuclear-receptor mediated endocrine disruptive effects, antiandrogenicity is frequently observed in aquatic environments and may pose a risk to aquatic organisms. Linking these effects to responsible chemicals is challenging and a great share of antiandrogenic activity detected in the environment has not been explained yet. To identify drivers of this effect at a hot spot of antiandrogenicity in the German river Holtemme, we applied effect-directed analysis (EDA) including a parallel fractionation approach, a downscaled luciferase reporter gene cell-based anti-AR-CALUX assay and LC-HRMS/MS non-target screening...
December 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29202294/comparative-live-imaging-of-in-vivo-erod-ethoxyresorufin-o-deethylase-induction-in-zebrafish-danio-rerio-and-fathead-minnow-pimephales-promelas-embryos-after-exposure-to-pahs-and-river-sediment-extracts
#18
Svenja Boehler, Ann-Kathrin Lörracher, Janine Schubert, Thomas Braunbeck
The measurement of EROD (ethoxyresorufin-O-deethylase) activity to determine the induction of CYP1A after exposure to dioxin-like substances is a well-established biomarker in fish. For reasons of animal welfare and implementations of new chemicals regulations (REACh), in vivo methods using zebrafish (Danio rerio) and medaka (Oryzias latipes) embryos have recently been developed to quantify CYP1A induction, which is visualized as mean intensity of the autofluorescent resorufin formed in living anaesthetized embryos...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29193243/dioxin-like-contaminants-are-no-longer-a-risk-to-the-american-eel-anguilla-rostrata-in-lake-ontario
#19
Sharilyn J Hoobin, Jonathan D Byer, Mehran Alaee, R Stephen Brown, Peter V Hodson
The embryotoxicity of extracts of American eels (Anguilla rostrata) was measured to determine whether maternally-derived contaminants contribute to the declining recruitment of eels to Lake Ontario. Sexually maturing, large yellow and silver eels were sampled in 2007 and 2008 from five locations in eastern Canada, including Lake Ontario; positive controls included eels from the Hudson River, United States, and Canal Dessel-Schoten, Belgium (European eel, Anguilla anguilla). Japanese medaka eggs were injected immediately after fertilization with 1 or 10 nL of eel extract, and after 12 days scored for signs of toxicity...
November 30, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29184138/centromere-evolution-and-cpg-methylation-during-vertebrate-speciation
#20
Kazuki Ichikawa, Shingo Tomioka, Yuta Suzuki, Ryohei Nakamura, Koichiro Doi, Jun Yoshimura, Masahiko Kumagai, Yusuke Inoue, Yui Uchida, Naoki Irie, Hiroyuki Takeda, Shinich Morishita
Centromeres and large-scale structural variants evolve and contribute to genome diversity during vertebrate speciation. Here, we perform de novo long-read genome assembly of three inbred medaka strains that are derived from geographically isolated subpopulations and undergo speciation. Using single-molecule real-time (SMRT) sequencing, we obtain three chromosome-mapped genomes of length ~734, ~678, and ~744Mbp with a resource of twenty-two centromeric regions of length 20-345kbp. Centromeres are positionally conserved among the three strains and even between four pairs of chromosomes that were duplicated by the teleost-specific whole-genome duplication 320-350 million years ago...
November 28, 2017: Nature Communications
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