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https://www.readbyqxmd.com/read/27906716/infants-with-technology-dependence-facilitating-the-road-to-home
#1
Jennifer D Bowles, Amy J Jnah, Desi M Newberry, Carol A Hubbard, Tracey Roberston
BACKGROUND: The incidence of premature infants with complex medical needs, dependent upon medical technology at discharge, is on the rise in the United States. PURPOSE: Preparing the family for the hospital-to-home transition can be challenging due to the complex medical and emotional needs of the vulnerable infant and the volume of subspecialty services and equipment required. METHODS/SEARCH STRATEGY: Relevant articles from PubMed, Google Scholar, CINAHLFINDINGS/RESULTS:: There is an increasing incidence of technology dependent infants discharged from neonatal intensive care units in the United States...
December 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27883030/spatial-quantitation-of-drugs-in-tissues-using-liquid-extraction-surface-analysis-mass-spectrometry-imaging
#2
John G Swales, Nicole Strittmatter, James W Tucker, Malcolm R Clench, Peter J H Webborn, Richard J A Goodwin
Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis to a quantitative analytical technique by employing a mimetic tissue model previously shown to be applicable for MALDI-MSI quantitation. Liver homogenate was used to generate a viable and molecularly relevant control matrix for spiked drug standards which can be frozen, sectioned and subsequently analyzed for the generation of calibration curves to quantify unknown tissue section samples...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27856553/crossing-the-threshold-bringing-biological-variation-to-the-foreground
#3
Janet M Batzli, Jennifer K Knight, Laurel M Hartley, April Cordero Maskiewicz, Elizabeth A Desy
Threshold concepts have been referred to as "jewels in the curriculum": concepts that are key to competency in a discipline but not taught explicitly. In biology, researchers have proposed the idea of threshold concepts that include such topics as variation, randomness, uncertainty, and scale. In this essay, we explore how the notion of threshold concepts can be used alongside other frameworks meant to guide instructional and curricular decisions, and we examine the proposed threshold concept of variation and how it might influence students' understanding of core concepts in biology focused on genetics and evolution...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27787262/fast-x-ray-microfluorescence-imaging-with-submicrometer-resolution-integrating-a-maia-detector-at-beamline-p06-at-petra%C3%A2-iii
#4
Ulrike Boesenberg, Christopher G Ryan, Robin Kirkham, D Peter Siddons, Matthias Alfeld, Jan Garrevoet, Teresa Núñez, Thorsten Claussen, Thorsten Kracht, Gerald Falkenberg
The high brilliance of third-generation synchrotron sources increases the demand for faster detectors to utilize the available flux. The Maia detector is an advanced imaging scheme for energy-dispersive detection realising dwell times per image-pixel as low as 50 µs and count rates higher than 10 × 10(6) s(-1). In this article the integration of such a Maia detector in the Microprobe setup of beamline P06 at the storage ring PETRA III at the Deutsches Elektronen-Synchrotron (DESY) in Hamburg, Germany, is described...
November 1, 2016: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/27782388/ambient-ionization-and-faims-mass-spectrometry-for-enhanced-imaging-of-multiply-charged-molecular-ions-in-biological-tissues
#5
Clara Leigh Feider, Natalia Elizondo, Livia S Eberlin
Ambient ionization mass spectrometry imaging (MSI) has been increasingly used to investigate the molecular distribution of biological tissue samples. Here, we report the integration and optimization of desorption electrospray ionization (DESI) and liquid-microjunction surface sampling probe (LMJ-SSP), and a chip-based high-field asymmetric waveform ion mobility spectrometry (FAIMS) device to image metabolites, lipids, and proteins in biological tissue samples. Optimized FAIMS parameters for specific molecular classes enabled semi-targeted detection of multiply-charged molecular species at enhanced signal-to-noise ratios (S/N), improved visualization of spatial distributions, and most importantly, allowed detection of species which were otherwise unseen by ambient ionization MSI alone...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27778241/monitoring-toxic-ionic-liquids-in-zebrafish-danio-rerio-with-desorption-electrospray-ionization-mass-spectrometry-imaging-desi-msi
#6
Consuelo J Perez, Alessandra Tata, Michel L de Campos, Chun Peng, Demian R Ifa
Ambient mass spectrometry imaging has become an increasingly powerful technique for the direct analysis of biological tissues in the open environment with minimal sample preparation and fast analysis times. In this study, we introduce desorption electrospray ionization mass spectrometry imaging (DESI-MSI) as a novel, rapid, and sensitive approach to localize the accumulation of a mildly toxic ionic liquid (IL), AMMOENG 130 in zebrafish (Danio rerio). The work demonstrates that DESI-MSI has the potential to rapidly monitor the accumulation of IL pollutants in aquatic organisms...
October 24, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27766177/direct-analysis-of-pharmaceutical-drugs-using-nano-desi-ms
#7
Carlos Cardoso-Palacios, Ingela Lanekoff
Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27765980/assessment-of-total-polyphenols-antioxidants-and-antimicrobial-properties-of-aonla-varieties
#8
Parveen Kumari, B S Khatkar
Phenolic content, antioxidant activities and antimicrobial activities of methanolic, ethanolic and ethyl acetate extracts of five different varieties of aonla (Emblica officinalis) fruits as well their powders were evaluated. Total polyphenolic content in fresh aonla fruit extracts varied from 70.6 to 159.4 mg GAE/g and their EC 50 (effective concentration) values for antioxidant activity ranged from 46.72 to 359.7 µg/ml. Significant varietal difference were observed in antioxidant activity of the extracts of fresh aonla fruit and powder...
July 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27760460/role-of-electrochemistry-in-desorption-ionization-mass-spectrometry-ls-desi-ms-of-aqueous-samples-containing-electrolyte-salts
#9
Wen Donq Looi, Laura Chamand, Blake Brown, Anna F Brajter-Toth
The ionization of liquid samples in desorption ionization mass spectrometry (LS DESI MS), supplied continuously through a liquid interface separated in space from the spray emitter, was investigated in this work. The role of electrochemistry (EC) in the ionization process was addressed. The visual (observation) of the operation of the LS DESI MS system showed a thick spray plume generated by electrosonic ionization (ESSI) forming a liquid cone at the liquid interface. When the liquid interface was grounded the cone collapsed and the MS ion signal was lost, indicating that the LS was carried to the MS inlet by the spray that emerged from the cone...
October 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27755337/incidence-risk-factors-and-location-of-articular-malreductions-of-the-tibial-plateau
#10
Brad Meulenkamp, C Ryan Martin, Nicholas Desy, Paul Duffy, Rob Korley, Shannon Puloski, Richard Buckley
OBJECTIVES: To define the incidence, risk factors and anatomic location of articular malreductions in operatively treated lateral tibial plateau fractures DESIGN:: Prospective Cohort Study SETTING:: Academic Level 1 Trauma CentrePatients/Participants: Study subjects were patients entered into a prospective cohort study of tibial plateau fractures. INTERVENTIONS: Surgical Fixation of tibial plateau fractures and post-operative computed tomography (CT) scans. MAIN OUTCOME MEASURES: The primary outcome was incidence of articular malreduction...
October 7, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27736105/individual-differences-in-the-impact-of-vicarious-racism-african-american-students-react-to-the-george-zimmerman-trial
#11
Tyler B Mason, Ralitsa S Maduro, Valerian J Derlega, Desi S Hacker, Barbara A Winstead, Jacqueline E Haywood
Objective: This research focused on how race-based rejection sensitivity (RS-Race) and components of racial identity intensify negative psychological reactions to an incident of vicarious racism. We examined how these individual difference variables directly and/or indirectly predicted African American students' reactions to the trial of George Zimmerman in the killing of the African American teenager, Trayvon Martin. Method: In Study 1, 471 African American students completed measures of RS-Race, thought intrusions about the Zimmerman trial, and outcome variables (negative affect about the Zimmerman trial and forgiveness for Mr...
October 13, 2016: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/27734938/rapid-detection-of-necrosis-in-breast-cancer-with-desorption-electrospray-ionization-mass-spectrometry
#12
Alessandra Tata, Michael Woolman, Manuela Ventura, Nicholas Bernards, Milan Ganguly, Adam Gribble, Bindesh Shrestha, Emma Bluemke, Howard J Ginsberg, Alex Vitkin, Jinzi Zheng, Arash Zarrine-Afsar
Identification of necrosis in tumors is of prognostic value in treatment planning, as necrosis is associated with aggressive forms of cancer and unfavourable outcomes. To facilitate rapid detection of necrosis with Mass Spectrometry (MS), we report the lipid MS profile of necrotic breast cancer with Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) imaging validated with statistical analysis and correlating pathology. This MS profile is characterized by (1) the presence of the ion of m/z 572.48 [Cer(d34:1) + Cl](-) which is a ceramide absent from the viable cancer subregions; (2) the absence of the ion of m/z 391...
October 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27732590/polyphenol-rich-diets-exacerbate-ampk-mediated-autophagy-decreasing-proliferation-of-mosquito-midgut-microbiota-and-extending-vector-lifespan
#13
Rodrigo Dutra Nunes, Guilherme Ventura-Martins, Débora Monteiro Moretti, Priscilla Medeiros-Castro, Carlucio Rocha-Santos, Carlos Renato de Oliveira Daumas-Filho, Paula Rego Barros Bittencourt-Cunha, Karina Martins-Cardoso, Cecília Oliveira Cudischevitch, Rubem Figueiredo Sadok Menna-Barreto, José Henrique Maia Oliveira, Desiely Silva Gusmão, Francisco José Alves Lemos, Daniela Sales Alviano, Pedro Lagerblad Oliveira, Carl Lowenberger, David Majerowicz, Ricardo Melo Oliveira, Rafael Dias Mesquita, Georgia Correa Atella, Mário Alberto Cardoso Silva-Neto
BACKGROUND: Mosquitoes feed on plant-derived fluids such as nectar and sap and are exposed to bioactive molecules found in this dietary source. However, the role of such molecules on mosquito vectorial capacity is unknown. Weather has been recognized as a major determinant of the spread of dengue, and plants under abiotic stress increase their production of polyphenols. RESULTS: Here, we show that including polyphenols in mosquito meals promoted the activation of AMP-dependent protein kinase (AMPK)...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27730523/an-assessment-of-the-utility-of-tissue-smears-in-rapid-cancer-profiling-with-desorption-electrospray-ionization-mass-spectrometry-desi-ms
#14
Michael Woolman, Alessandra Tata, Emma Bluemke, Delaram Dara, Howard J Ginsberg, Arash Zarrine-Afsar
Mass spectrometry imaging with desorption electrospray ionization mass spectrometry (DESI-MS) is used to characterize cancer from ex vivo slices of tissues. The process is time-consuming. The use of tissue smears for DESI-MS analysis has been proposed as it eliminates the time required to snap-freeze and section the tissue. To assess the utility of tissue smears for rapid cancer characterization, principal component analysis (PCA) was performed to evaluate the concordance between DESI-MS profiles of breast cancer from tissue slices and smears prepared on various surfaces...
October 11, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27717474/genome-wide-development-and-deployment-of-informative-intron-spanning-and-intron-length-polymorphism-markers-for-genomics-assisted-breeding-applications-in-chickpea
#15
Rishi Srivastava, Deepak Bajaj, Yogesh K Sayal, Prabina K Meher, Hari D Upadhyaya, Rajendra Kumar, Shailesh Tripathi, Chellapilla Bharadwaj, Atmakuri R Rao, Swarup K Parida
The discovery and large-scale genotyping of informative gene-based markers is essential for rapid delineation of genes/QTLs governing stress tolerance and yield component traits in order to drive genetic enhancement in chickpea. A genome-wide 119169 and 110491 ISM (intron-spanning markers) from 23129 desi and 20386 kabuli protein-coding genes and 7454 in silico InDel (insertion-deletion) (1-45-bp)-based ILP (intron-length polymorphism) markers from 3283 genes were developed that were structurally and functionally annotated on eight chromosomes and unanchored scaffolds of chickpea...
November 2016: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/27704473/direct-visualization-of-neurotransmitters-in-rat-brain-slices-by-desorption-electrospray-ionization-mass-spectrometry-imaging-desi-ms
#16
Anna Maria A P Fernandes, Pedro H Vendramini, Renan Galaverna, Nicolas V Schwab, Luciane C Alberici, Rodinei Augusti, Roger F Castilho, Marcos N Eberlin
Mass spectrometry imaging (MSI) of neurotransmitters has so far been mainly performed by matrix-assisted laser desorption/ionization (MALDI) where derivatization reagents, deuterated matrix and/or high resolution, or tandem MS have been applied to circumvent problems with interfering ion peaks from matrix and from isobaric species. We herein describe the application of desorption electrospray ionization mass spectrometry imaging (DESI)-MSI in rat brain coronal and sagittal slices for direct spatial monitoring of neurotransmitters and choline with no need of derivatization reagents and/or deuterated materials...
October 4, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27704091/online-coupling-techniques-in-ambient-mass-spectrometry
#17
Shuting Xu, Yiding Zhang, Linnan Xu, Yu Bai, Huwei Liu
Since ambient mass spectrometry (AMS) has been proven to have low matrix effects and high salt tolerance, great efforts have been made for online coupling of several analytical techniques with AMS. These analytical techniques include gas chromatography (GC), liquid chromatography (LC), capillary electrophoresis (CE), surface plasmon resonance (SPR), and electrochemistry flow cells. Various ambient ionization sources, represented by desorption electrospray ionization (DESI) and direct analysis in real time (DART), have been utilized as interfaces for the online coupling techniques...
October 17, 2016: Analyst
https://www.readbyqxmd.com/read/27695461/a-high-resolution-indel-insertion-deletion-markers-anchored-consensus-genetic-map-identifies-major-qtls-governing-pod-number-and-seed-yield-in-chickpea
#18
Rishi Srivastava, Mohar Singh, Deepak Bajaj, Swarup K Parida
Development and large-scale genotyping of user-friendly informative genome/gene-derived InDel markers in natural and mapping populations is vital for accelerating genomics-assisted breeding applications of chickpea with minimal resource expenses. The present investigation employed a high-throughput whole genome next-generation resequencing strategy in low and high pod number parental accessions and homozygous individuals constituting the bulks from each of two inter-specific mapping populations [(Pusa 1103 × ILWC 46) and (Pusa 256 × ILWC 46)] to develop non-erroneous InDel markers at a genome-wide scale...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27680662/transcriptome-landscape-of-perennial-wild-cicer-microphyllum-uncovers-functionally-relevant-molecular-tags-regulating-agronomic-traits-in-chickpea
#19
Rishi Srivastava, Deepak Bajaj, Ayushi Malik, Mohar Singh, Swarup K Parida
The RNA-sequencing followed by de-novo transcriptome assembly identified 11621 genes differentially xpressed in roots vs. shoots of a wild perennial Cicer microphyllum. Comparative analysis of transcriptomes between microphyllum and cultivated desi cv. ICC4958 detected 12772 including 3242 root- and 1639 shoot-specific microphyllum genes with 85% expression validation success rate. Transcriptional reprogramming of microphyllum root-specific genes implicates their possible role in regulating differential natural adaptive characteristics between wild and cultivated chickpea...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27659048/cardiolipins-are-biomarkers-of-mitochondria-rich-thyroid-oncocytic-tumors
#20
Jialing Zhang, Wendong Yu, Seung Ryu, John Lin, Gerardo Buentello, Robert Tibshirani, James Suliburk, Livia Schiavinato Eberlin
Oncocytic tumors are characterized by an excessive eosinophilic, granular cytoplasm due to aberrant accumulation of mitochondria. Mutations in mitochondrial DNA occurs in oncocytic thyroid tumors, but there is no information about their lipid composition which might reveal candidate theranostic molecules. Here we used desorption electrospray ionization mass spectrometry (DESI-MS) to image and chemically characterize the lipid composition of oncocytic thyroid tumors, as compared to non-oncocytic thyroid tumors and normal thyroid samples...
September 22, 2016: Cancer Research
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