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https://www.readbyqxmd.com/read/28333282/anchorless-cell-surface-proteins-function-as-laminin-binding-adhesins-in-lactobacillus-rhamnosus-fsmm22
#1
Ni Putu Desy Aryantini, Daisuke Kondoh, Keita Nishiyama, Yuji Yamamoto, Takao Mukai, I Nengah Sujaya, Tadasu Urashima, Kenji Fukuda
Anchorless cell surface proteins (CSPs) were extracted with 1 M lithium chloride solution from Lactobacillus rhamnosus FSMM22. Loss of the anchorless CSPs resulted in a two-fold decrease in FSMM22 cells bound to a constitutive extracellular matrix glycoprotein, laminin, in vitro. DNA-binding protein HU, glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase, and 30S ribosomal protein S19 (RpsS) were identified by mass spectrometry in the extract as laminin-binding adhesins. Among the four proteins, RpsS was immunohistochemically confirmed to exist on the cell surface...
March 9, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28320493/the-nicu-environment-infusing-single-family-room-benefits-into-the-open-bay-setting
#2
Jenna L Meredith, Amy Jnah, Desi Newberry
Two distinct architectural designs are found in today's NICUs-the open-bay (OPBY) and the single-family room (SFR) designs. When neonatology was recognized as a medical subspecialty in the 1970s, the OPBY design was the only platform offered to neonates and families. The OPBY design facilitated communication between staff, collegiality, and interprofessional collaboration among members of the neonatal team. Over time, pitfalls to the design were recognized, including increased transmission of sound and light...
March 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/28315234/ammonium-bicarbonate-addition-improves-the-detection-of-proteins-by-desorption-electrospray-ionization-mass-spectrometry
#3
Elahe Honarvar, Andre R Venter
The analysis of protein by desorption electrospray ionization mass spectrometry (DESI-MS) is considered impractical due to a mass-dependent loss in sensitivity with increase in protein molecular weights. With the addition of ammonium bicarbonate to the DESI-MS analysis the sensitivity towards proteins by DESI was improved. The signal to noise ratio (S/N) improvement for a variety of proteins increased between 2- to 3-fold relative to solvent systems containing formic acid and more than seven times relative to aqueous methanol spray solvents...
March 17, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28306315/hard-two-photon-contribution-to-elastic-lepton-proton-scattering-determined-by-the-olympus-experiment
#4
B S Henderson, L D Ice, D Khaneft, C O'Connor, R Russell, A Schmidt, J C Bernauer, M Kohl, N Akopov, R Alarcon, O Ates, A Avetisyan, R Beck, S Belostotski, J Bessuille, F Brinker, J R Calarco, V Carassiti, E Cisbani, G Ciullo, M Contalbrigo, R De Leo, J Diefenbach, T W Donnelly, K Dow, G Elbakian, P D Eversheim, S Frullani, Ch Funke, G Gavrilov, B Gläser, N Görrissen, D K Hasell, J Hauschildt, Ph Hoffmeister, Y Holler, E Ihloff, A Izotov, R Kaiser, G Karyan, J Kelsey, A Kiselev, P Klassen, A Krivshich, I Lehmann, P Lenisa, D Lenz, S Lumsden, Y Ma, F Maas, H Marukyan, O Miklukho, R G Milner, A Movsisyan, M Murray, Y Naryshkin, R Perez Benito, R Perrino, R P Redwine, D Rodríguez Piñeiro, G Rosner, U Schneekloth, B Seitz, M Statera, A Thiel, H Vardanyan, D Veretennikov, C Vidal, A Winnebeck, V Yeganov
The OLYMPUS Collaboration reports on a precision measurement of the positron-proton to electron-proton elastic cross section ratio, R_{2γ}, a direct measure of the contribution of hard two-photon exchange to the elastic cross section. In the OLYMPUS measurement, 2.01 GeV electron and positron beams were directed through a hydrogen gas target internal to the DORIS storage ring at DESY. A toroidal magnetic spectrometer instrumented with drift chambers and time-of-flight scintillators detected elastically scattered leptons in coincidence with recoiling protons over a scattering angle range of ≈20° to 80°...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28304192/direct-analysis-of-samples-of-various-origin-and-composition-using-specific-types-of-mass-spectrometry
#5
Hubert Byliński, Jacek Gębicki, Tomasz Dymerski, Jacek Namieśnik
One of the major sources of error that occur during chemical analysis utilizing the more conventional and established analytical techniques is the possibility of losing part of the analytes during the sample preparation stage. Unfortunately, this sample preparation stage is required to improve analytical sensitivity and precision. Direct techniques have helped to shorten or even bypass the sample preparation stage; and in this review, we comment of some of the new direct techniques that are mass-spectrometry based...
March 17, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28303051/near-isogenic-lines-of-desi-chickpea-cicer-arietinum-l-that-differ-in-milling-ease-differences-in-chemical-composition
#6
Jennifer A Wood, Edmund J Knights, Grant M Campbell, Mingan Choct
Milling performance is an important attribute for desi chickpea and other pulses, as varieties that are more difficult-to-mill lead to processing yield loss and damage to the resulting split cotyledons (dhal) such as chipping and abrasion which are unattractive to the consumer. Poor milling performance leads to poor dhal quality and therefore lower prices and profitability along the pulse value chain. The Pulse Breeding Australia Chickpea Program identified near-isogenic desi lines that differed in seed shape and milling yields, however it was unknown whether this was due simply to a difference in physical forces on the seed during milling, mediated by seed shape, or whether there were underlying differences in chemical composition that could explain these differences...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28299204/the-coadministration-of-unoxidized-and-oxidized-desi-ghee-ameliorates-the-toxic-effects-of-thermally-oxidized-ghee-in-rabbits
#7
Alam Zeb, Islam Uddin
Desi Ghee was thermally oxidized at 160°C for 9 h and characterized for peroxide value (PV), free fatty acid (FFA), thiobarbituric acid reactive substances (TBARS), radical scavenging activity (RSA), and fatty acid and cholesterol composition using GC-MS. Oxidized (OG) and normal ghee (NG) were fed to rabbits in different doses. Blood was collected for hematology and biochemical analyses after 7 and 14 days. The oxidation of desi ghee increased the PV, FFA, and TBARS values and showed a decline in the RSA values...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28294642/cost-effectiveness-of-sequenced-treatment-of-rheumatoid-arthritis-with-targeted-immune-modulators
#8
Jeroen P Jansen, Devin Incerti, Alex Mutebi, Desi Peneva, Joanna MacEwan, Bradley Stolshek, Primal Kaur, Mahdi Gharaibeh, Vibeke Strand
AIMS: To determine the cost-effectiveness of treatment sequences of biologic disease-modifying antirheumatic drugs or Janus kinase/STAT pathway inhibitors (collectively referred to as bDMARDs) versus conventional DMARDs (cDMARDs) from the US societal perspective for treatment of patients with moderately to severely active rheumatoid arthritis (RA) with inadequate responses to cDMARDs. MATERIALS AND METHODS: We developed an individual patient simulation model that assesses the impact of treatments on disease based on clinical trial data and real-world evidence...
March 15, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28294229/molecular-imaging-of-small-molecule-drugs-in-animal-tissues-using-laser-desorption-postionization-mass-spectrometry
#9
Jiaxin Chen, Yongjun Hu, Qiao Lu, Pengchao Wang, Huaqi Zhan
Localization and quantification of the target drug in tissues is a key indicator of efficacy in drug discovery. In contrast to established methods that require matrices and complex sample pretreatment steps, matrix-free and low cost in situ analysis of small molecule drugs by mass spectrometry (MS) remains challenging. Here, we present a novel approach, laser desorption postionization (LDPI), which is coupled to a linear time-of-flight (TOF) MS and used to image the distribution of acriflavine (ACF) directly from a histological section of mouse kidney without any matrix or sample pretreatment...
March 15, 2017: Analyst
https://www.readbyqxmd.com/read/28292895/diagnosis-of-prostate-cancer-by-desorption-electrospray-ionization-mass-spectrometric-imaging-of-small-metabolites-and-lipids
#10
Shibdas Banerjee, Richard N Zare, Robert J Tibshirani, Christian A Kunder, Rosalie Nolley, Richard Fan, James D Brooks, Geoffrey A Sonn
Accurate identification of prostate cancer in frozen sections at the time of surgery can be challenging, limiting the surgeon's ability to best determine resection margins during prostatectomy. We performed desorption electrospray ionization mass spectrometry imaging (DESI-MSI) on 54 banked human cancerous and normal prostate tissue specimens to investigate the spatial distribution of a wide variety of small metabolites, carbohydrates, and lipids. In contrast to several previous studies, our method included Krebs cycle intermediates (m/z <200), which we found to be highly informative in distinguishing cancer from benign tissue...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28254286/synchrotron-based-xrd-from-rat-bone-of-different-age-groups
#11
D V Rao, G E Gigante, R Cesareo, A Brunetti, N Schiavon, T Akatsuka, T Yuasa, T Takeda
Synchrotron-based XRD spectra from rat bone of different age groups (w, 56 w and 78w), lumber vertebra at early stages of bone formation, Calcium hydroxyapatite (HAp) [Ca10(PO4)6(OH)2] bone fill with varying composition (60% and 70%) and bone cream (35-48%), has been acquired with 15keV synchrotron X-rays. Experiments were performed at Desy, Hamburg, Germany, utilizing the Resonant and Diffraction beamline (P9), with 15keV X-rays (λ=0.82666 A(0)). Diffraction data were quantitatively analyzed using the Rietveld refinement approach, which allowed us to characterize the structure of these samples in their early stages...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28253619/determination-of-peroxide-explosive-tatp-and-related-compounds-by-dielectric-barrier-discharge-ionization-mass-spectrometry-dbdi-ms
#12
Sebastian Hagenhoff, Joachim Franzke, Heiko Hayen
Dielectric barrier discharge ionization-mass spectrometry (DBDI-MS), which is based on the use of a low temperature helium plasma as ionization source, is used for the determination of trace amounts of triacetone triperoxide (TATP) and its homologue diacetone diperoxide (DADP) from surfaces. TATP is observed as [M+NH4](+) adduct, whereas DADP is observed as [M+O+NH4](+). Measurement of DADP with varying deuteration degrees (DADP, DADP-d6 and DADP-d12) indicates that DADP undergoes oxidation when ionized by DBDI...
March 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28250595/genetic-variation-of-a-global-germplasm-collection-of-chickpea-cicer-arietinum-l-including-italian-accessions-at-risk-of-genetic-erosion
#13
C De Giovanni, S Pavan, F Taranto, V Di Rienzo, M M Miazzi, A R Marcotrigiano, G Mangini, C Montemurro, L Ricciardi, C Lotti
Chickpea (Cicer arietinum L.) is one of the most important legumes worldwide. We addressed this study to the genetic characterization of a germplasm collection from main chickpea growing countries. Several Italian traditional landraces at risk of genetic erosion were included in the analysis. Twenty-two simple sequence repeat (SSR) markers, widely used to explore genetic variation in plants, were selected and yielded 218 different alleles. Structure analysis and hierarchical clustering indicated that a model with three distinct subpopulations best fits the data...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28247296/detection-of-metastatic-breast-and-thyroid-cancer-in-lymph-nodes-by-desorption-electrospray-ionization-mass-spectrometry-imaging
#14
Jialing Zhang, Clara L Feider, Chandandeep Nagi, Wendong Yu, Stacey A Carter, James Suliburk, Hop S Tran Cao, Livia S Eberlin
Ambient ionization mass spectrometry has been widely applied to image lipids and metabolites in primary cancer tissues with the purpose of detecting and understanding metabolic changes associated with cancer development and progression. Here, we report the use of desorption electrospray ionization mass spectrometry (DESI-MS) to image metastatic breast and thyroid cancer in human lymph node tissues. Our results show clear alterations in lipid and metabolite distributions detected in the mass spectra profiles from 42 samples of metastatic thyroid tumors, metastatic breast tumors, and normal lymph node tissues...
February 28, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28239987/effects-of-alloantibodies-to-human-leukocyte-antigen-on-endothelial-expression-and-serum-levels-of-thrombomodulin
#15
S Béland, P Vallin, O Désy, E Lévesque, S A De Serres
Essentials The effect of alloantibodies on the endothelial expression of thrombomodulin is unknown. Thrombomodulin was quantified in stimulated endothelial cells and measured in serum samples. Anti-human leukocyte antigen (HLA) I vs. II antibodies have different effects on thrombomodulin. Anti-HLA II antibodies may promote a prothrombotic state and contribute to microangiopathy. SUMMARY: Rationale Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory transmembrane protein expressed on endothelial cells...
February 26, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28211480/visualisation-of-abscisic-acid-and-12-oxo-phytodienoic-acid-in-immature-phaseolus-vulgaris-l-seeds-using-desorption-electrospray-ionisation-imaging-mass-spectrometry
#16
Hirofumi Enomoto, Takuya Sensu, Kei Sato, Futoshi Sato, Thanai Paxton, Emi Yumoto, Koji Miyamoto, Masashi Asahina, Takao Yokota, Hisakazu Yamane
The plant hormone abscisic acid (ABA) and the jasmonic acid related-compound 12-oxo-phytodienoic acid (OPDA) play crucial roles in seed development, dormancy, and germination. However, a lack of suitable techniques for visualising plant hormones has restricted the investigation of their biological mechanisms. In the present study, desorption electrospray ionisation-imaging mass spectrometry (DESI-IMS), a powerful tool for visualising metabolites in biological tissues, was used to visualise ABA and OPDA in immature Phaseolus vulgaris L...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208268/medical-swab-analysis-using-desorption-electrospray-ionization-mass-spectrometry-a-noninvasive-approach-for-mucosal-diagnostics
#17
Pamela Pruski, David A MacIntyre, Holly V Lewis, Paolo Inglese, Gonçalo D S Correia, Trevor T Hansel, Phillip R Bennett, Elaine Holmes, Zoltan Takats
Medical swabs are routinely used worldwide to sample human mucosa for microbiological screening with culture methods. These are usually time-consuming and have a narrow focus on screening for particular microorganism species. As an alternative, direct mass spectrometric profiling of the mucosal metabolome provides a broader window into the mucosal ecosystem. We present for the first time a minimal effort/minimal-disruption technique for augmenting the information obtained from clinical swab analysis with mucosal metabolome profiling using desorption electrospray ionization mass spectrometry (DESI-MS) analysis...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28202379/comprehensive-preoperative-work-up-and-surgical-treatment-of-low-grade-tumor-benign-lesion-related-temporal-lobe-epilepsy
#18
Rui Feng, Jie Hu, Jinsong Wu, Liqin Lang, Chengxin Ma, Shize Jiang, Bing Sun, Xin Gu, Li Pan
OBJECTIVE: Generally low-grade tumor/benign lesion related temporal lobe epilepsy (LGT/BL-TLE) is considered easier to treat and has better prognosis when compared to non-lesional TLE. However, multiple disputes exist in surgical management of this epilepsy entity. This study aims to discuss comprehensive preoperative work-up, surgical strategies and outcome of it. METHODS: A retrospective review of sixty LGT/BL-TLE cases which underwent comprehensive preoperative work-up and then resective surgeries was conducted...
February 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28194988/personal-information-from-latent-fingerprints-using-desorption-electrospray-ionization-mass-spectrometry-and-machine-learning
#19
Zhenpeng Zhou, Richard N Zare
Desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) was applied to latent fingerprints to obtain not only spatial patterns but also chemical maps. Samples with similar lipid compositions as those of the fingerprints were collected by swiping a glass slide across the forehead of consenting adults. A machine learning model called gradient boosting tree ensemble (GDBT) was applied to the samples that allowed us to distinguish between different genders, ethnicities, and ages (within 10 years)...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28193010/variations-in-the-abundance-of-lipid-biomarker-ions-in-mass-spectrometry-images-correlate-to-tissue-density
#20
Jade Bilkey, Alessandra Tata, Trevor D McKee, Andreia M Porcari, Emma Bluemke, Michael Woolman, Manuela Ventura, Marcos N Eberlin, Arash Zarrine-Afsar
While mass spectrometry (MS) imaging is widely used to investigate the molecular composition of ex vivo slices of cancerous tumors, little is known about how variations in the cellular properties of cancer tissue can influence cancer biomarker ion images. To better understand the basis for variations in the abundances of cancer biomarker ions seen in MS images of relatively homogeneous ex vivo tumor samples, sections of snap frozen human breast cancer murine xenografts were subjected to desorption electrospray ionization mass spectrometry (DESI-MS) imaging...
December 20, 2016: Analytical Chemistry
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