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https://www.readbyqxmd.com/read/28805105/economic-burden-of-multiple-myeloma-among-patients-in-successive-lines-of-therapy-in-the-united-states
#1
Joanna P MacEwan, Katharine Batt, Wes Yin, Desi Peneva, Steve Sison, Seanna Vine, Clara Chen
This study characterized the costs of multiple myeloma (MM) during first-line (1L), second-line (2L) and third-line (3L) treatment from the US payer perspective. Patients with ≥2 outpatient or ≥1 inpatient claims with a primary MM diagnosis and 12 months continuous enrollment post index were identified in a retrospective claims database between 1 July 2006 and 30 June 2013. A cost per-patient per-month (PPPM) metric was used to calculate total all-cause and anti-MM pharmacy costs in 1L, 2L, and 3L treatment...
August 13, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28799592/rapid-determination-of-the-tumour-stroma-ratio-in-squamous-cell-carcinomas-with-desorption-electrospray-ionization-mass-spectrometry-desi-ms-a-proof-of-concept-demonstration
#2
Michael Woolman, Alessandra Tata, Delaram Dara, Jalna Meens, Elisa D'Arcangelo, Consuelo J Perez, Shamina Saiyara Prova, Emma Bluemke, Howard J Ginsberg, Demian Ifa, Alison McGuigan, Laurie Ailles, Arash Zarrine-Afsar
Squamous cell carcinomas constitute a major class of head & neck cancers, where the tumour stroma ratio (TSR) carries prognostic information. Patients affected by stroma-rich tumours exhibit a poor prognosis and a higher chance of relapse. As such, there is a need for a technology platform that allows rapid determination of the tumour stroma ratio. In this work, we provide a proof-of-principle demonstration that Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) can be used to determine tumour stroma ratios...
August 11, 2017: Analyst
https://www.readbyqxmd.com/read/28792022/ambient-mass-spectrometry-in-metabolomics
#3
REVIEW
Chaevien S Clendinen, María Eugenia Monge, Facundo M Fernández
Since the introduction of desorption electrospray ionization (DESI) mass spectrometry (MS), ambient MS methods have seen increased use in a variety of fields from health to food science. Increasing its popularity in metabolomics, ambient MS offers limited sample preparation, rapid and direct analysis of liquids, solids, and gases, in situ and in vivo analysis, and imaging. The metabolome consists of a constantly changing collection of small (<1.5 kDa) molecules. These include endogenous molecules that are part of primary metabolism pathways, secondary metabolites with specific functions such as signaling, chemicals incorporated in the diet or resulting from environmental exposures, and metabolites associated with the microbiome...
August 9, 2017: Analyst
https://www.readbyqxmd.com/read/28764825/living-with-tricuspid-atresia-case-report-with-review-of-literature
#4
Brittany Watson Frock, Amy J Jnah, Desi M Newberry
Tricuspid atresia (TA) is a rare congenital heart defect in which the right atrioventricular connection, the tricuspid valve, is absent. As a result, there is no direct communication between the right atrium and right ventricle. Surgical treatment, including the Fontan procedure, is indicated yet palliative, leaving patients with various lifelong complications. A comprehensive literature review revealed a paucity of evidence-based education on the identification, evaluation, management, treatment, and life span implications of TA...
July 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/28762560/ambient-mass-spectrometry-direct-analysis-of-dimethoate-tebuconazole-and-trifloxystrobin-on-olive-and-vine-leaves-by-desorption-electrospray-ionization-interface
#5
Lucia Mainero Rocca, Juri Cecca, Nunziata L'Episcopo, Giovanni Fabrizi
A new field of application for a relatively new mass-spectrometric interface such as desorption electrospray ionization was evaluated. For this purpose, its behavior was tested versus quantitative analysis of dimethoate, trifloxystrobin and tebuconazole directly on olive and vine leaves surface. The goal was workers exposure assessment during field re-entry operations since evidence suggests an association between chronic occupational exposure to some agrochemicals and severe adverse effects. DESI gave good response working in positive ionization mode, while numerous test were necessary for the choice of a unique blend of spray solvents suitable for all three substances...
August 1, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28762398/effect-of-elimination-on-antifouling-and-ph-responsive-properties-of-carboxybetaine-materials
#6
Wan-Ning Yu, Desi Hanna Natalia Manik, Chun-Jen Huang, Lai-Kwan Chau
Carboxybetaine (CB)-based zwitterionic materials have attracted considerable attention due to their dual antifouling and functionalizable properties. In this communication, the elimination effect on the antifouling and pH-responsive properties of CB materials was investigated. We synthesize β- and α-substituted methyl CB materials to investigate the occurrence of elimination in the ethylene intercharge arm in a harsh basic solution. This work provides molecular understanding of a structure-property relationship of the CB moiety for material development...
August 1, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28758821/further-evidence-for-curricular-influence-on-student-connectedness
#7
Janice L Farlow, Benjamin Ulrich, Desi Schiess, Andrew Piropato, Avinash Inabathula, Nathanael Moore, Michelle Chung, Antwione Haywood
No abstract text is available yet for this article.
July 31, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28755258/towards-high-resolution-tissue-imaging-using-nanospray-desorption-electrospray-ionization-mass-spectrometry-coupled-to-shear-force-microscopy
#8
Son N Nguyen, Ryan L Sontag, James P Carson, Richard A Corley, Charles Ansong, Julia Laskin
Constant mode ambient mass spectrometry imaging (MSI) of tissue sections with high lateral resolution of better than 10 μm was performed by combining shear force microscopy with nanospray desorption electrospray ionization (nano-DESI). Shear force microscopy enabled precise control of the distance between the sample and nano-DESI probe during MSI experiments and provided information on sample topography. Proof-of-concept experiments were performed using lung and brain tissue sections representing spongy and dense tissues, respectively...
July 28, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28751895/a-multiple-qtl-seq-strategy-delineates-potential-genomic-loci-governing-flowering-time-in-chickpea
#9
Rishi Srivastava, Hari D Upadhyaya, Rajendra Kumar, Anurag Daware, Udita Basu, Philanim W Shimray, Shailesh Tripathi, Chellapilla Bharadwaj, Akhilesh K Tyagi, Swarup K Parida
Identification of functionally relevant potential genomic loci using an economical, simpler and user-friendly genomics-assisted breeding strategy is vital for rapid genetic dissection of complex flowering time quantitative trait in chickpea. A high-throughput multiple QTL-seq strategy was employed in two inter (Cicer arietinum desi accession ICC 4958 × C reticulatum wild accession ICC 17160)- and intra (ICC 4958 × C. arietinum kabuli accession ICC 8261)-specific RIL mapping populations to identify the major QTL genomic regions governing flowering time in chickpea...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28751672/the-lncrna-connectivity-map-using-lncrna-signatures-to-connect-small-molecules-lncrnas-and-diseases
#10
Haixiu Yang, Desi Shang, Yanjun Xu, Chunlong Zhang, Li Feng, Zeguo Sun, Xinrui Shi, Yunpeng Zhang, Junwei Han, Fei Su, Chunquan Li, Xia Li
Well characterized the connections among diseases, long non-coding RNAs (lncRNAs) and drugs are important for elucidating the key roles of lncRNAs in biological mechanisms in various biological states. In this study, we constructed a database called LNCmap (LncRNA Connectivity Map), available at http://www.bio-bigdata.com/LNCmap/ , to establish the correlations among diseases, physiological processes, and the action of small molecule therapeutics by attempting to describe all biological states in terms of lncRNA signatures...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747408/respiratory-muscle-endurance-training-reduces-the-o2-cost-of-cycling-and-perceived-exertion-in-obese-adolescents
#11
Desy Salvadego, Alessandro Sartorio, Fiorenza Agosti, Gabriella Tringali, Alessandra Patrizi, Miriam Isola, Antonella LoMauro, Andrea Aliverti, Bruno Grassi
In obesity the increased O2 cost of breathing negatively affects the O2 cost of exercise and exercise tolerance. The purpose of the study was to determine whether, in obese adolescents, the addition of respiratory muscle endurance training (RMET) (isocapnic hyperpnea) to a standard body mass reduction program decreases the O2 cost of exercise and perceived exertion and increases exercise tolerance. 9 male obese adolescents (16.0±1.4 years [x±SD], body mass 114.4±22.3 kg) underwent 3 weeks of RMET (5 days/week); 8 age-and sex- matched obese adolescents underwent the standard body mass reduction program (CTRL)...
July 26, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28743728/imaging-regiospecific-lipid-turnover-in-mouse-brain-with-desorption-electrospray-ionization-mass-spectrometry
#12
Richard H Carson, Charlotte R Lewis, Mercede N Erickson, Anna P Zagieboylo, Bradley C Naylor, Kelvin W Li, Paul B Farnsworth, John C Price
Compartmentalization of metabolism into specific regions of the cell, tissue and organ, is critical to life for all organisms. Mass spectrometric imaging techniques have been valuable in identifying and quantifying concentrations of metabolites in specific locations of cells and tissues, but a true understanding of metabolism requires measurement of metabolite flux on a spatially resolved basis. Here we utilize desorption electrospray ionization mass spectrometry (DESI-MS) to measure lipid turnover in the brains of mice...
July 25, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28732130/abnormalities-in-the-24-hour-rhythm-of-skin-temperature-in-cirrhosis-sleep-wake-and-general-clinical-implications
#13
Maria Garrido, Desy Saccardo, Michele De Rui, Elia Vettore, Alberto Verardo, Paolo Carraro, Nicola Di Vitofrancesco, Ali R Mani, Paolo Angeli, Massimo Bolognesi, Sara Montagnese
BACKGROUND & AIMS: Sleep preparation/onset are associated with peripheral vasodilatation and a decrease in body temperature. The hyperdynamic syndrome exhibited by patients with cirrhosis may impinge on sleep preparation, thus contributing to their difficulties falling asleep. The aim of this study was the assessment of skin temperature, in relation to sleep-wake patterns, in patients with cirrhosis. METHODS: Fifty three subjects were initially recruited, and 46 completed the study...
July 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28712615/predicting-real-world-effectiveness-of-cancer-therapies-using-overall-survival-and-progression-free-survival-from-clinical-trials-empirical-evidence-for-the-asco-value-framework
#14
Darius N Lakdawalla, Jason Shafrin, Ningqi Hou, Desi Peneva, Seanna Vine, Jinhee Park, Jie Zhang, Ron Brookmeyer, Robert A Figlin
OBJECTIVES: To measure the relationship between randomized controlled trial (RCT) efficacy and real-world effectiveness for oncology treatments as well as how this relationship varies depending on an RCT's use of surrogate versus overall survival (OS) endpoints. METHODS: We abstracted treatment efficacy measures from 21 phase III RCTs reporting OS and either progression-free survival or time to progression endpoints in breast, colorectal, lung, ovarian, and pancreatic cancers...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28708975/short-term-costs-of-preeclampsia-to-the-united-states-health-care-system
#15
Warren Stevens, Tiffany Shih, Devin Incerti, Thanh G N Ton, Henry C Lee, Desi Peneva, George A Macones, Baha M Sibai, Anupam B Jena
BACKGROUND: Preeclampsia is a leading cause of maternal morbidity and mortality and adverse neonatal outcomes. Little is known about the extent of the health and cost burden of preeclampsia in the United States. OBJECTIVE: This study sought to quantify the annual epidemiological and health care cost burden of preeclampsia to both mothers and infants in the United States in 2012. STUDY DESIGN: We used epidemiological and econometric methods to assess the annual cost of preeclampsia in the United States using a combination of population-based and administrative data sets: the National Center for Health Statistics Vital Statistics on Births, the California Perinatal Quality Care Collaborative Databases, the US Health Care Cost and Utilization Project database, and a commercial claims data set...
June 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28703327/testing-the-situationism-scale-in-europe-scale-validation-self-regulation-and-regional-differences
#16
Megan E Roberts, Lisa Wagner, Saša Zorjan, Enikö Nèmeth, Désie van Toor, Michał Czaplinski
The term situationism refers to an individual's belief about the importance of a behaviour's context. This study tested whether the degree of situationism expressed by individuals in various regions of Europe was consistent with self-regulation and cross-cultural theories. The English version of a Situationism Scale (measuring beliefs about the relation between the environment and one's own behaviour) was translated into five additional languages: Dutch, German, Hungarian, Italian and Slovenian. Young adults (N = 1106, MAge  = 22...
August 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28669069/cyanobacterial-and-rhizobial-inoculation-modulates-the-plant-physiological-attributes-and-nodule-microbial-communities-of-chickpea
#17
Radha Prasanna, Balasubramanian Ramakrishnan, Kaur Simranjit, Kunal Ranjan, Amrita Kanchan, Firoz Hossain, Lata Nain
The present investigation aimed to understand the influence of two plant growth promoting cyanobacterial formulations (Anabaena-Mesorhizobium ciceri biofilm and Anabaena laxa), along with Mesorhizobium ciceri, on the symbiotic performance of five each of desi- and kabuli-chickpea cultivars. Inoculation with cyanobacterial formulations led to significant interactions with different cultivars, in terms of fresh weight and number of nodules, the concentration of nodular leghemoglobin, and the number of pods. The inoculant A...
July 1, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28668975/marker-assisted-introgression-of-resistance-to-fusarium-wilt-race-2-in-pusa-256-an-elite-cultivar-of-desi-chickpea
#18
Aditya Pratap, Sushil K Chaturvedi, Rakhi Tomar, Neha Rajan, Nupur Malviya, Mahender Thudi, P R Saabale, Umashanker Prajapati, Rajeev K Varshney, N P Singh
Fusarium wilt caused by F. oxysporum f. sp. ciceris causes extensive damage to chickpea (Cicer arietinum L.) in many parts of the world. In the central part of India, pathogen race 2 (Foc 2) causes severe yield losses. We initiated molecular marker-assisted backcrossing (MABC) using desi cultivar, Vijay, as a donor to introgress resistance to this race (Foc2) in Pusa 256, another elite desi cultivar of chickpea. To confirm introgression of resistance for this race, foreground selection was undertaken using two SSR markers (TA 37 and TA110), with background selection to observe the recovery of recurrent parent genome using 45 SSRs accommodated in 8 multiplexes...
July 1, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28666029/expected-accuracy-of-proximal-and-distal-temperature-estimated-by-wireless-sensors-in-relation-to-their-number-and-position-on-the-skin
#19
Enrico Longato, Maria Garrido, Desy Saccardo, Camila Montesinos Guevara, Ali R Mani, Massimo Bolognesi, Piero Amodio, Andrea Facchinetti, Giovanni Sparacino, Sara Montagnese
A popular method to estimate proximal/distal temperature (TPROX and TDIST) consists in calculating a weighted average of nine wireless sensors placed on pre-defined skin locations. Specifically, TPROX is derived from five sensors placed on the infra-clavicular and mid-thigh area (left and right) and abdomen, and TDIST from four sensors located on the hands and feet. In clinical practice, the loss/removal of one or more sensors is a common occurrence, but limited information is available on how this affects the accuracy of temperature estimates...
2017: PloS One
https://www.readbyqxmd.com/read/28620847/faster-more-reproducible-desi-ms-for-biological-tissue-imaging
#20
Jocelyn Tillner, Vincen Wu, Emrys A Jones, Steven D Pringle, Tamas Karancsi, Andreas Dannhorn, Kirill Veselkov, James S McKenzie, Zoltan Takats
A new, more robust sprayer for desorption electrospray ionization (DESI) mass spectrometry imaging is presented. The main source of variability in DESI is thought to be the uncontrolled variability of various geometric parameters of the sprayer, primarily the position of the solvent capillary, or more specifically, its positioning within the gas capillary or nozzle. If the solvent capillary is off-center, the sprayer becomes asymmetrical, making the geometry difficult to control and compromising reproducibility...
June 15, 2017: Journal of the American Society for Mass Spectrometry
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