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https://www.readbyqxmd.com/read/28035435/method-development-towards-qualitative-and-semi-quantitative-analysis-of-multiple-pesticides-from-food-surfaces-and-extracts-by-desorption-electrospray-ionization-mass-spectrometry-as-a-preselective-tool-for-food-control
#1
Stefanie Gerbig, Gerold Stern, Hubertus E Brunn, Rolf-Alexander Düring, Bernhard Spengler, Sabine Schulz
Direct analysis of fruit and vegetable surfaces is an important tool for in situ detection of food contaminants such as pesticides. We tested three different ways to prepare samples for the qualitative desorption electrospray ionization mass spectrometry (DESI-MS) analysis of 32 pesticides found on nine authentic fruits collected from food control. Best recovery rates for topically applied pesticides (88%) were found by analyzing the surface of a glass slide which had been rubbed against the surface of the food...
December 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28018400/identification-and-expression-analysis-of-candidate-genes-involved-in-carotenoid-biosynthesis-in-chickpea-seeds
#2
Mohammad K Rezaei, Amit Deokar, Bunyamin Tar'an
Plant carotenoids have a key role in preventing various diseases in human because of their antioxidant and provitamin A properties. Chickpea is a good source of carotenoid among legumes and its diverse germplasm and genome accessibility makes it a good model for carotenogenesis studies. The structure, location, and copy numbers of genes involved in carotenoid biosynthesis were retrieved from the chickpea genome. The majority of the single nucleotide polymorphism (SNPs) within these genes across five diverse chickpea cultivars was synonymous mutation...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28009574/p13-the-embl-macromolecular-crystallography-beamline-at-the-low-emittance-petra-iii-ring-for%C3%A2-high-and-low-energy-phasing-with-variable-beam-focusing
#3
Michele Cianci, Gleb Bourenkov, Guillaume Pompidor, Ivars Karpics, Johanna Kallio, Isabel Bento, Manfred Roessle, Florent Cipriani, Stefan Fiedler, Thomas R Schneider
The macromolecular crystallography P13 beamline is part of the European Molecular Biology Laboratory Integrated Facility for Structural Biology at PETRA III (DESY, Hamburg, Germany) and has been in user operation since mid-2013. P13 is tunable across the energy range from 4 to 17.5 keV to support crystallographic data acquisition exploiting a wide range of elemental absorption edges for experimental phase determination. An adaptive Kirkpatrick-Baez focusing system provides an X-ray beam with a high photon flux and tunable focus size to adapt to diverse experimental situations...
January 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28005381/molecular-characterization-of-organosulfur-compounds-in-biodiesel-and-diesel-fuel-secondary-organic-aerosol
#4
Sandra L Blair, Amanda C MacMillan, Greg T Drozd, Allen H Goldstein, Rosalie K Chu, Ljiljana Paša-Tolić, Jared B Shaw, Nikola Tolić, Peng Lin, Julia Laskin, Alexander Laskin, Sergey A Nizkorodov
Secondary organic aerosol (SOA), formed in the photooxidation of diesel fuel, biodiesel fuel, and 20% biodiesel fuel/80% diesel fuel mixture, are prepared under high-NOx conditions in the presence and absence of sulfur dioxide (SO2), ammonia (NH3), and relative humidity (RH). The composition of condensed-phase organic compounds in SOA is measured using several complementary techniques including aerosol mass spectrometry (AMS), high-resolution nanospray desorption electrospray ionization mass spectrometry (nano-DESI/HRMS), and ultrahigh resolution and mass accuracy 21T Fourier transform ion cyclotron resonance mass spectrometry (21T FT-ICR MS)...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27982107/recent-breeding-programs-enhanced-genetic-diversity-in-both-desi-and-kabuli-varieties-of-chickpea-cicer-arietinum-l
#5
Mahendar Thudi, Annapurna Chitikineni, Xin Liu, Weiming He, Manish Roorkiwal, Wei Yang, Jianbo Jian, Dadakhalandar Doddamani, Pooran M Gaur, Abhishek Rathore, Srinivasan Samineni, Rachit K Saxena, Dawen Xu, Narendra P Singh, Sushil K Chaturvedi, Gengyun Zhang, Jun Wang, Swapan K Datta, Xun Xu, Rajeev K Varshney
In order to understand the impact of breeding on genetic diversity and gain insights into temporal trends in diversity in chickpea, a set of 100 chickpea varieties released in 14 countries between 1948 and 2012 were re-sequenced. For analysis, the re-sequencing data for 29 varieties available from an earlier study was also included. Copy number variations and presence absence variations identified in the present study have potential to drive phenotypic variations for trait improvement. Re-sequencing of a large number of varieties has provided opportunities to inspect the genetic and genomic changes reflecting the history of breeding, which we consider as breeding signatures and the selected loci may provide targets for crop improvement...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27976698/epithelial-ovarian-carcinoma-diagnosis-by-desorption-electrospray-ionization-mass-spectrometry-imaging
#6
Maria Luisa Dória, James S McKenzie, Anna Mroz, David L Phelps, Abigail Speller, Francesca Rosini, Nicole Strittmatter, Ottmar Golf, Kirill Veselkov, Robert Brown, Sadaf Ghaem-Maghami, Zoltan Takats
Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption electrospray mass spectrometry imaging (DESI-MSI) generates spatially resolved metabolic profiles of tissues and supports an objective investigation of tumour biology. In this study, various ovarian tissue types were analysed by DESI-MSI and co-registered with their corresponding haematoxylin and eosin (H&E) stained images...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27973782/constant-distance-mode-nanospray-desorption-electrospray-ionization-mass-spectrometry-imaging-of-biological-samples-with-complex-topography
#7
Son N Nguyen, Andrey V Liyu, Rosalie K Chu, Christopher R Anderton, Julia Laskin
A new approach for constant-distance mode mass spectrometry imaging (MSI) of biological samples using nanospray desorption electrospray ionization (nano-DESI) was developed by integrating a shear-force probe with the nano-DESI probe. The technical concept and basic instrumental setup, as well as the general operation of the system are described. Mechanical dampening of resonant oscillations due to the presence of shear forces between the probe and the sample surface enabled the constant-distance imaging mode via a computer-controlled closed-feedback loop...
December 28, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27906716/infants-with-technology-dependence-facilitating-the-road-to-home
#8
Jennifer D Bowles, Amy J Jnah, Desi M Newberry, Carol A Hubbard, Tracey Roberston
BACKGROUND: The incidence of premature infants with complex medical needs, dependent upon medical technology at discharge, is on the rise in the United States. PURPOSE: Preparing the family for the hospital-to-home transition can be challenging due to the complex medical and emotional needs of the vulnerable infant and the volume of subspecialty services and equipment required. METHODS/SEARCH STRATEGY: Relevant articles from PubMed, Google Scholar, CINAHLFINDINGS/RESULTS:: There is an increasing incidence of technology dependent infants discharged from neonatal intensive care units in the United States...
December 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27883030/spatial-quantitation-of-drugs-in-tissues-using-liquid-extraction-surface-analysis-mass-spectrometry-imaging
#9
John G Swales, Nicole Strittmatter, James W Tucker, Malcolm R Clench, Peter J H Webborn, Richard J A Goodwin
Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis to a quantitative analytical technique by employing a mimetic tissue model previously shown to be applicable for MALDI-MSI quantitation. Liver homogenate was used to generate a viable and molecularly relevant control matrix for spiked drug standards which can be frozen, sectioned and subsequently analyzed for the generation of calibration curves to quantify unknown tissue section samples...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27856553/crossing-the-threshold-bringing-biological-variation-to-the-foreground
#10
Janet M Batzli, Jennifer K Knight, Laurel M Hartley, April Cordero Maskiewicz, Elizabeth A Desy
Threshold concepts have been referred to as "jewels in the curriculum": concepts that are key to competency in a discipline but not taught explicitly. In biology, researchers have proposed the idea of threshold concepts that include such topics as variation, randomness, uncertainty, and scale. In this essay, we explore how the notion of threshold concepts can be used alongside other frameworks meant to guide instructional and curricular decisions, and we examine the proposed threshold concept of variation and how it might influence students' understanding of core concepts in biology focused on genetics and evolution...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27787262/fast-x-ray-microfluorescence-imaging-with-submicrometer-resolution-integrating-a-maia-detector-at-beamline-p06-at-petra%C3%A2-iii
#11
Ulrike Boesenberg, Christopher G Ryan, Robin Kirkham, D Peter Siddons, Matthias Alfeld, Jan Garrevoet, Teresa Núñez, Thorsten Claussen, Thorsten Kracht, Gerald Falkenberg
The high brilliance of third-generation synchrotron sources increases the demand for faster detectors to utilize the available flux. The Maia detector is an advanced imaging scheme for energy-dispersive detection realising dwell times per image-pixel as low as 50 µs and count rates higher than 10 × 10(6) s(-1). In this article the integration of such a Maia detector in the Microprobe setup of beamline P06 at the storage ring PETRA III at the Deutsches Elektronen-Synchrotron (DESY) in Hamburg, Germany, is described...
November 1, 2016: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/27782388/ambient-ionization-and-faims-mass-spectrometry-for-enhanced-imaging-of-multiply-charged-molecular-ions-in-biological-tissues
#12
Clara L Feider, Natalia Elizondo, Livia S Eberlin
Ambient ionization mass spectrometry imaging (MSI) has been increasingly used to investigate the molecular distribution of biological tissue samples. Here, we report the integration and optimization of desorption electrospray ionization (DESI) and liquid-microjunction surface sampling probe (LMJ-SSP) with a chip-based high-field asymmetric waveform ion mobility spectrometry (FAIMS) device to image metabolites, lipids, and proteins in biological tissue samples. Optimized FAIMS parameters for specific molecular classes enabled semitargeted detection of multiply charged molecular species at enhanced signal-to-noise ratios (S/N), improved visualization of spatial distributions, and, most importantly, allowed detection of species which were unseen by ambient ionization MSI alone...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27778241/monitoring-toxic-ionic-liquids-in-zebrafish-danio-rerio-with-desorption-electrospray-ionization-mass-spectrometry-imaging-desi-msi
#13
Consuelo J Perez, Alessandra Tata, Michel L de Campos, Chun Peng, Demian R Ifa
Ambient mass spectrometry imaging has become an increasingly powerful technique for the direct analysis of biological tissues in the open environment with minimal sample preparation and fast analysis times. In this study, we introduce desorption electrospray ionization mass spectrometry imaging (DESI-MSI) as a novel, rapid, and sensitive approach to localize the accumulation of a mildly toxic ionic liquid (IL), AMMOENG 130 in zebrafish (Danio rerio). The work demonstrates that DESI-MSI has the potential to rapidly monitor the accumulation of IL pollutants in aquatic organisms...
October 24, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27766177/direct-analysis-of-pharmaceutical-drugs-using-nano-desi-ms
#14
Carlos Cardoso-Palacios, Ingela Lanekoff
Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27765980/assessment-of-total-polyphenols-antioxidants-and-antimicrobial-properties-of-aonla-varieties
#15
Parveen Kumari, B S Khatkar
Phenolic content, antioxidant activities and antimicrobial activities of methanolic, ethanolic and ethyl acetate extracts of five different varieties of aonla (Emblica officinalis) fruits as well their powders were evaluated. Total polyphenolic content in fresh aonla fruit extracts varied from 70.6 to 159.4 mg GAE/g and their EC 50 (effective concentration) values for antioxidant activity ranged from 46.72 to 359.7 µg/ml. Significant varietal difference were observed in antioxidant activity of the extracts of fresh aonla fruit and powder...
July 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27760460/role-of-electrochemistry-in-desorption-ionization-mass-spectrometry-ls-desi-ms-of-aqueous-samples-containing-electrolyte-salts
#16
Wen Donq Looi, Laura Chamand, Blake Brown, Anna Brajter-Toth
The ionization of LS samples in desorption ionization mass spectrometry (LS DESI MS), supplied continuously through a LS interface separated in space from the spray emitter, was investigated in this work. The role of electrochemistry (EC) in the ionization process was addressed. The visual (observation) of the operation of the LS DESI MS system showed a thick spray plume generated by the electrosonic spray ionization (ESSI), forming a liquid cone at the LS interface. When the LS interface was grounded the cone collapsed and the MS ion signal was lost, indicating that the LS was carried to the MS inlet by the spray that emerged from the cone...
December 12, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27755337/incidence-risk-factors-and-location-of-articular-malreductions-of-the-tibial-plateau
#17
Brad Meulenkamp, C Ryan Martin, Nicholas Desy, Paul Duffy, Rob Korley, Shannon Puloski, Richard Buckley
OBJECTIVES: To define the incidence, risk factors and anatomic location of articular malreductions in operatively treated lateral tibial plateau fractures DESIGN:: Prospective Cohort Study SETTING:: Academic Level 1 Trauma CentrePatients/Participants: Study subjects were patients entered into a prospective cohort study of tibial plateau fractures. INTERVENTIONS: Surgical Fixation of tibial plateau fractures and post-operative computed tomography (CT) scans. MAIN OUTCOME MEASURES: The primary outcome was incidence of articular malreduction...
October 7, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27736105/individual-differences-in-the-impact-of-vicarious-racism-african-american-students-react-to-the-george-zimmerman-trial
#18
Tyler B Mason, Ralitsa S Maduro, Valerian J Derlega, Desi S Hacker, Barbara A Winstead, Jacqueline E Haywood
Objective: This research focused on how race-based rejection sensitivity (RS-Race) and components of racial identity intensify negative psychological reactions to an incident of vicarious racism. We examined how these individual difference variables directly and/or indirectly predicted African American students' reactions to the trial of George Zimmerman in the killing of the African American teenager, Trayvon Martin. Method: In Study 1, 471 African American students completed measures of RS-Race, thought intrusions about the Zimmerman trial, and outcome variables (negative affect about the Zimmerman trial and forgiveness for Mr...
October 13, 2016: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/27734938/rapid-detection-of-necrosis-in-breast-cancer-with-desorption-electrospray-ionization-mass-spectrometry
#19
Alessandra Tata, Michael Woolman, Manuela Ventura, Nicholas Bernards, Milan Ganguly, Adam Gribble, Bindesh Shrestha, Emma Bluemke, Howard J Ginsberg, Alex Vitkin, Jinzi Zheng, Arash Zarrine-Afsar
Identification of necrosis in tumors is of prognostic value in treatment planning, as necrosis is associated with aggressive forms of cancer and unfavourable outcomes. To facilitate rapid detection of necrosis with Mass Spectrometry (MS), we report the lipid MS profile of necrotic breast cancer with Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) imaging validated with statistical analysis and correlating pathology. This MS profile is characterized by (1) the presence of the ion of m/z 572.48 [Cer(d34:1) + Cl](-) which is a ceramide absent from the viable cancer subregions; (2) the absence of the ion of m/z 391...
October 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27732590/polyphenol-rich-diets-exacerbate-ampk-mediated-autophagy-decreasing-proliferation-of-mosquito-midgut-microbiota-and-extending-vector-lifespan
#20
Rodrigo Dutra Nunes, Guilherme Ventura-Martins, Débora Monteiro Moretti, Priscilla Medeiros-Castro, Carlucio Rocha-Santos, Carlos Renato de Oliveira Daumas-Filho, Paula Rego Barros Bittencourt-Cunha, Karina Martins-Cardoso, Cecília Oliveira Cudischevitch, Rubem Figueiredo Sadok Menna-Barreto, José Henrique Maia Oliveira, Desiely Silva Gusmão, Francisco José Alves Lemos, Daniela Sales Alviano, Pedro Lagerblad Oliveira, Carl Lowenberger, David Majerowicz, Ricardo Melo Oliveira, Rafael Dias Mesquita, Georgia Correa Atella, Mário Alberto Cardoso Silva-Neto
BACKGROUND: Mosquitoes feed on plant-derived fluids such as nectar and sap and are exposed to bioactive molecules found in this dietary source. However, the role of such molecules on mosquito vectorial capacity is unknown. Weather has been recognized as a major determinant of the spread of dengue, and plants under abiotic stress increase their production of polyphenols. RESULTS: Here, we show that including polyphenols in mosquito meals promoted the activation of AMP-dependent protein kinase (AMPK)...
October 2016: PLoS Neglected Tropical Diseases
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