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https://www.readbyqxmd.com/read/28340472/characterization-of-an-unknown-impurity-in-doxofylline-using-lc-ms-and-nmr
#1
Peixi Zhu, Jingxian Lu, Liya Hong, Weike Su, Ann Van Schepdael, Erwin Adams
During quality control of doxofylline, a novel impurity was detected, which was above the identification threshold defined by ICH. First, a liquid chromatographic method compatible with mass spectrometric (MS) detection was developed. Based on tandem multistage MS and high resolution MS data, the unknown impurity was found to consist of two theophylline groups connected by a methylene group. The structure was further confirmed by 1D and 2D nuclear magnetic resonance (NMR) experiments after semi-preparative isolation...
March 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28340448/structural-correlates-of-creative-thinking-in-patients-with-bipolar-disorder-and-healthy-controls-a-voxel-based-morphometry-study
#2
Pei-Chi Tu, Yi-Hsuan Kuan, Cheng-Ta Li, Tung-Ping Su
BACKGROUND: This study investigated the structural correlates of creative thinking in patients with bipolar disorder (BD) to understand the possible neural mechanism of creative thinking in BD. METHODS: We recruited 59 patients with BD I or BD II (35.3±8.5 y) and 56 age- and sex-matched controls (HCs; 34±7.4 y). Each participant underwent structural magnetic resonance imaging and evaluation of creative thinking, which was assessed using two validated tools: the Chinese version of the Abbreviated Torrance Test for Adults for divergent thinking and the Chinese Word Remote Associates Test for remote association...
March 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340309/analytical-techniques-in-lipidomics-state-of-the-art
#3
Kamil Jurowski, Kamila Kochan, Justyna Walczak, Małgorzata Barańska, Wojciech Piekoszewski, Bogusław Buszewski
Current studies related to lipid identification and determination, or lipidomics in biological samples, are one of the most important issues in modern bioanalytical chemistry. There are many articles dedicated to specific analytical strategies used in lipidomics in various kinds of biological samples. However, in such literature, there is lack of articles dedicated to a comprehensive review of the actual analytical methodologies used in lipidomics. The aim of this article is to characterize the lipidomics methods used in modern bioanalysis according to the methodological point of view: 1) chromatography/separation methods, 2) spectroscopic methods and 3) mass spectrometry and also hyphenated methods...
March 24, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28340292/combined-spiroergometry-and-31-p-mrs-of-human-calf-muscle-during-high-intensity-exercise
#4
K Moll, A Gussew, C Hein, N Stutzig, J R Reichenbach
Simultaneous measurements of pulmonary oxygen consumption (VO2 ), carbon dioxide exhalation (VCO2 ) and phosphorus magnetic resonance spectroscopy ((31) P-MRS) are valuable in physiological studies to evaluate muscle metabolism during specific loads. Therefore, the aim of this study was to adapt a commercially available spirometric device to enable measurements of VO2 and VCO2 whilst simultaneously performing (31) P-MRS at 3 T. Volunteers performed intense plantar flexion of their right calf muscle inside the MR scanner against a pneumatic MR-compatible pedal ergometer...
March 24, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28340244/bupropion-administration-increases-resting-state-functional-connectivity-in-dorso-medial-prefrontal-cortex
#5
Ewelina Rzepa, Zola Dean, Ciara McCabe
Background: Patients on the selective serotonergic re-uptake inhibitors (SSRI) like citalopram report emotional blunting. We have shown previously that citalopram reduces resting-state functional connectivity (RSFC) in healthy volunteers in a number of brain regions including the dorso-medial prefrontal cortex, which may be related to its clinical effects. Bupropion is a dopaminergic and noradrenergic re-uptake inhibitor (DNRI) and is not reported to cause emotional blunting. However how bupropion affects RSFC in healthy controls remains unknown...
March 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28340213/effects-of-alcohol-dependence-severity-on-neural-correlates-of-delay-discounting
#6
Aaron C Lim, Anita Cservenka, Lara A Ray
Aims: The current study examines the relationship between alcohol dependence severity and delay discounting neural activation. Methods: Participants (N = 17; 6 female) completed measures of alcohol use and severity and a functional magnetic resonance imaging version of a delay discounting task. Results: Alcohol dependence severity was negatively associated with activation in superior frontal gyrus during impulsive relative to delayed decisions, and positively associated with activation in paracingulate gyrus and frontal pole in delayed relative to impulsive decisions...
March 18, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28340008/pre-treatment-interleukin-6-levels-strongly-affect-bone-erosion-progression-and-repair-detected-by-magnetic-resonance-imaging-in-rheumatoid-arthritis-patients
#7
Yasushi Kondo, Yuko Kaneko, Hiroaki Sugiura, Shunsuke Matsumoto, Naoshi Nishina, Masataka Kuwana, Masahiro Jinzaki, Tsutomu Takeuchi
Objective.: To examine the relationship between MRI structural damage and repair and plasma inflammatory cytokines in patients with RA. Methods.: A total of 88 newly diagnosed, untreated RA patients were enrolled. Contrast MRI of the dominant hand and X-rays of the hands and feet were performed at baseline and 1 year later. MR images were evaluated using RA MRI scoring, and X-ray. were assessed by the modified total Sharp score. Erosion progression was defined as changes in RA MRI scoring erosion or modified total Sharp score erosion of >0...
March 8, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339975/the-pain-interprofessional-curriculum-design-model
#8
Judy Watt-Watson, Leila Lax, Robyn Davies, Sylvia Langlois, Jon Oskarsson, Lalitha Raman-Wilms
Objective.:  Although the University of Toronto Centre for the Study of Pain has successfully implemented an Interfaculty Pain Curriculum since 2002, we have never formalized the process in a design model. Therefore, our primary aim was to develop a model that provided an overview of dynamic, interrelated elements that have been important in our experience. A secondary purpose was to use the model to frame an interactive workshop for attendees interested in developing their own pain curricula...
March 3, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339663/cardiac-involvement-in-granulomatosis-with-polyangiitis-a-magnetic-resonance-imaging-study-of-31-consecutive-patients
#9
Grégory Pugnet, Hervé Gouya, Xavier Puéchal, Benjamin Terrier, André Kahan, Paul Legmann, Loïc Guillevin, Olivier Vignaux
Objectives.: Specific cardiac involvement in granulomatosis with polyangiitis (GPA) is probably underestimated since many of these conditions are subclinical. The objective of this study was to assess the prevalence and patterns of cardiac abnormalities detected by cardiac MRI (CMRI) in patients with GPA. Methods.: Thirty-one consecutive patients with newly diagnosed or relapsing GPA underwent CMRI to assess morphological, functional, perfusion at rest and delayed enhancement abnormalities...
February 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339630/mr-tractography-in-short-lasting-unilateral-neuralgiform-headache-attacks-with-conjunctival-injection-and-tearing-sunct-patients-case-reports
#10
Ozlem Coskun, Murat Ucar, Doga Vuralli, Funuzar Yildirim, Rumeysa Cetinkaya, Suna Akin Takmaz, Serap Ucler
Background. : Short-lasting unilateral neuralgiform headache attack with conjunctival injection and tearing (SUNCT) is one of the trigeminal autonomic cephalalgias where neurovascular compression was detected in neuroimaging in recent years. Case. : We report two cases, a 52-year-old adult and a 69-year-old elderly patient with short-lasting and recurrent headache combined with cranial autonomic features. Diffusion tensor imaging (DTI) and magnetic resonance (MR) tractography of both patients outlined structural changes of the trigeminal nerve revealing neurovascular compression...
February 11, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339449/reversal-of-progressive-conscious-disturbance-with-epidural-blood-patch-for-cerebrospinal-fluid-leakage-at-c2-level
#11
Yi-Chen Lai, Yuan-Yi Chia, Wei-Hung Lien
Intracranial hypotension syndrome (IHS) is generally caused by cerebrospinal fluid (CSF) leakage. Complications include bilateral subdural hygroma or haematoma and herniation of the cerebellar tonsils. Epidural blood patch (EBP) therapy is indicated if conservative treatment is ineffective. We reported the case of a 46-year-old man with a history of postural headache and dizziness. The patient was treated with bed rest and daily hydration with 2000 mL of fluid for 2 weeks. However, dizziness and headache did not resolve, and he became drowsy and disoriented with incomprehensible speech...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339445/transforaminal-endoscopic-decompression-for-a-giant-epidural-gas-containing-pseudocyst-a-case-report-and-literature-review
#12
Bin Zhu, Liang Jiang, Xiao Guang Liu
The isolated epidural gas-containing pseudocyst is an uncommon pathogenic factor for severe pain of the lower limb as a result of nerve root compression. After reviewing these rare cases reported in the literature, we found that the name, pathogenesis, and treatment strategy of this pathology remained controversial. The most common treatment is conservative treatment or percutaneous aspiration which might result inpoor pain relief and high recurrence rates. Moreover, the patient who received open surgery had good clinical outcome; however, he or she might experience a significant soft tissue injury...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339441/the-role-of-the-ligamentum-flavum-area-as-a-morphological-parameter-of-lumbar-central-spinal-stenosis
#13
Young Uk Kim, Jun Young Park, Doo Hwan Kim, Myung-Hwan Karm, Jae-Young Lee, Jee In Yoo, Sung Won Chon, Jeong Hun Suh
BACKGROUND: Hypertrophy of the ligamentum flavum (LF) has been considered as a major cause of lumbar central spinal stenosis (LCSS). Previous studies have found that ligamentum flavum thickness (LFT) is correlated with aging, disc degeneration, and lumbar spinal stenosis. However, hypertrophy is different from thickness. Thus, to evaluate hypertrophy of the whole LF, we devised a new morphological parameter, called the ligamentum flavum area (LFA). OBJECTIVES: We hypothesized that the LFA is a key morphologic parameter in the diagnosis of LCSS...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339428/does-conservative-treatment-change-the-brain-in-patients-with-chronic-musculoskeletal-pain-a-systematic-review
#14
Jeroen Kregel, Iris Coppieters, Robby DePauw, Anneleen Malfliet, Lieven Danneels, Jo Nijs, Barbara Cagnie, Mira Meeus
BACKGROUND: Chronic musculoskeletal pain is characterized by maladaptive central neuroplastic changes. Many observational studies have demonstrated that chronic pain states are associated with brain alterations regarding structure and/or function. Rehabilitation of patients with chronic musculoskeletal pain may include cognitive, exercise, or multimodal therapies. OBJECTIVE: The current review aims to provide a constructive overview of the existing literature reporting neural correlates, based on brain magnetic resonance imaging (MRI) techniques, following conservative treatment in chronic musculoskeletal pain patients...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339357/development-of-a-score-for-assessment-of-radiologic-damage-in-large-vessel-vasculitis-combined-arteritis-damage-score-cards
#15
Daiki Nakagomi, Claire Cousins, Jan Sznajd, Shunsuke Furuta, Aladdin J Mohammad, Raashid Luqmani, David Jayne
OBJECTIVES: Outcome assessment in large-vessel vasculitis (LVV) remains challenging and this impairs patient management and the conduct of clinical studies. Previous proposals for outcome tools have not included imaging. This study aimed to develop an imaging score to quantify damage in LVV and to assess the difference between Takayasu (TAK) and giant cell arteritis (GCA). METHODS: Ninety-six patients (41 TAK, 55 GCA) were identified from local registries at two University Hospitals in the UK...
March 13, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339304/mid-treatment-magnetic-resonance-imaging-in-pediatric-intracranial-low-grade-gliomas-treated-with-proton-beam-therapy
#16
Radhika Sreeraman Kumar, Ronny L Rotondo, Julie A Bradley, Tamara Vern-Gross, Soon Huh, Daniel J Indelicato
No abstract text is available yet for this article.
March 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28339286/advantages-of-arthroscopic-rotator-cuff-repair-with-a-transosseous-suture-technique-a-prospective-randomized-controlled-trial
#17
Pietro Randelli, Carlo Alberto Stoppani, Carlo Zaolino, Alessandra Menon, Filippo Randelli, Paolo Cabitza
BACKGROUND: Rotator cuff tear is a common finding in patients with painful, poorly functioning shoulders. The surgical management of this disorder has improved greatly and can now be fully arthroscopic. PURPOSE: To evaluate clinical and radiological results of arthroscopic rotator cuff repair using 2 different techniques: single-row anchor fixation versus transosseous hardware-free suture repair. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28339285/is-the-necrosis-wall-adc-ratio-useful-for-the-differentiation-of-benign-and-malignant-breast-lesions
#18
Irmak Durur-Subasi, Afak Durur-Karakaya, Adem Karaman, Mehmet Seker, Elif Demirci, Fatih Alper
OBJECTIVES: To determine whether the necrosis/wall apparent diffusion coefficient (ADC) ratio is useful for the malignant-benign differentiation of necrotic breast lesions. METHODS: Breast magnetic resonance imaging (MRI) was performed using a 3T system. In this retrospective study, calculation of the necrosis/wall ADC ratio was based on ADC values measured from the necrosis and from the wall of malignant and benign breast lesions by diffusion-weighted imaging (DWI)...
March 24, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28339272/connecting-few-body-inelastic-decay-to-quantum-correlations-in-a-many-body-system-a-weakly-coupled-impurity-in-a-resonant-fermi-gas
#19
Sébastien Laurent, Matthieu Pierce, Marion Delehaye, Tarik Yefsah, Frédéric Chevy, Christophe Salomon
We study three-body recombination in an ultracold Bose-Fermi mixture. We first show theoretically that, for weak interspecies coupling, the loss rate is proportional to Tan's contact. Second, using a ^{7}Li/^{6}Li mixture we probe the recombination rate in both the thermal and dual superfluid regimes. We find excellent agreement with our model in the BEC-BCS crossover. At unitarity where the fermion-fermion scattering length diverges, we show that the loss rate is proportional to n_{f}^{4/3}, where n_{f} is the fermionic density...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339260/dynamic-chiral-magnetic-effect-and-faraday-rotation-in-macroscopically-disordered-helical-metals
#20
J Ma, D A Pesin
We develop an effective medium theory for electromagnetic wave propagation through gapless nonuniform systems with a dynamic chiral magnetic effect. The theory allows us to calculate macroscopic-disorder-induced corrections to the values of optical, as well as chiral magnetic conductivities. In particular, we show that spatial fluctuations of the optical conductivity induce corrections to the effective value of the chiral magnetic conductivity. The absolute value of the effect varies strongly depending on the system parameters, but yields the leading frequency dependence of the polarization rotation and circular dichroism signals...
March 10, 2017: Physical Review Letters
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