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https://www.readbyqxmd.com/read/29475206/association-between-forefoot-bone-length-and-performance-in-male-endurance-runners
#1
Hiromasa Ueno, Tadashi Suga, Kenji Takao, Takahiro Tanaka, Jun Misaki, Yuto Miyake, Akinori Nagano, Tadao Isaka
Recently, we reported that the forefoot bones were longer in sprinters than in non-sprinters, and that longer forefoot bones correlated with higher sprint performance in sprinters. To further understand the superiority of long forefoot bones in athletic performance, we examined whether forefoot bone length was associated with running performance in endurance runners. The length of the forefoot bones of the big and second toes were measured using magnetic resonance imaging in 45 male well-trained endurance runners and 45 male untrained subjects...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475200/cardiovascular-associations-with-abnormal-brain-magnetic-resonance-imaging-in-neonates-with-hypoxic-ischemic-encephalopathy-undergoing-therapeutic-hypothermia-and-rewarming
#2
Kiran S More, Pankaj Sakhuja, Regan E Giesinger, Joseph Y Ting, Matthew Keyzers, Jesal N Sheth, Anie Lapointe, Amish Jain, Aideen M Moore, Steven P Miller, Patrick J McNamara
OBJECTIVE:  This article compares hemodynamic characteristics of neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH) with normal versus abnormal brain magnetic resonance imaging (MRI). METHODS:  Serial echocardiography (echo) was performed within 24 hours, after 48 to 72 hours of cooling, within 24 hours of normothermia, and after starting feeds. Pulmonary hemodynamics, cardiac output, and ventricular function were evaluated...
February 23, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29475186/an-optofluidic-metasurface-for-lateral-flow-through-detection-of-breast-cancer-biomarker
#3
Yifei Wang, Md Azahar Ali, Edmond K C Chow, Liang Dong, Meng Lu
The rapid growth of point-of-care tests demands for biosensors with high sensitivity and small size. This paper demonstrates an optofluidic metasurface that combines silicon-on-insulator (SOI) nanophotonics and nanofluidics to realize a high-performance, lateral flow-through biosensor. The metasurface is made of a periodic array of silicon nanoposts on an SOI substrate, and functionalized with specific receptor molecules. Bonding of a polydimethylsiloxane slab directly onto the surface results in an ultracompact biosensor, where analyte solutions are restricted to flow only in the space between the nanoposts...
February 17, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29475172/brain-network-alteration-in-patients-with-temporal-lobe-epilepsy-with-cognitive-impairment
#4
Hongyu Yang, Chao Zhang, Chang Liu, Tao Yu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n=21) and cognitive nonimpairment (CNI) groups (n=19) according to MoCA performance...
February 20, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29475070/distinct-regions-of-the-hippocampus-are-associated-with-memory-for-different-spatial-locations
#5
Brittany M Jeye, Sean P MacEvoy, Jessica M Karanian, Scott D Slotnick
In the present functional magnetic resonance imaging (fMRI) study, we aimed to evaluate whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. In Experiment 1, during the study phase, participants viewed abstract shapes in the left or right visual field while maintaining central fixation. At test, old shapes were presented at fixation and participants classified each shape as previously in the "left" or "right" visual field followed by an "unsure"-"sure"-"very sure" confidence rating...
February 20, 2018: Brain Research
https://www.readbyqxmd.com/read/29475054/intravenous-infusion-of-mesenchymal-stem-cells-reduces-epileptogenesis-in-a-rat-model-of-status-epilepticus
#6
Shinobu Fukumura, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Masahito Nakazaki, Hiroshi Nagahama, Tomonori Morita, Takuro Sakai, Hiroyuki Tsutsumi, Jeffery D Kocsis, Osamu Honmou
OBJECTIVE: Status epilepticus (SE) causes neuronal cell death, aberrant mossy fiber sprouting (MFS), and cognitive deteriorations. The present study tested the hypothesis that systemically infused mesenchymal stem cells (MSCs) reduce epileptogenesis by inhibiting neuronal cell death and suppressing aberrant MFS, leading to cognitive function preservation in a rat model of epilepsy. METHODS: SE was induced using the lithium-pilocarpine injection model. The seizure frequency was scored using a video-monitoring system and the Morris water maze test was carried out to evaluate cognitive function...
February 14, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29474998/-anthropometric-prediction-of-visceral-adipose-tissue-in-persons-with-motor-complete-spinal-cord-injury
#7
Liron S McCauley, Ryan M Sumrell, Ashraf S Gorgey
BACKGROUND: Spinal cord injury (SCI) results in increased accumulation of visceral adipose tissue (VAT). Anthropometrics may provide an alternative to estimate VAT cross section area (CSA) compared to magnetic resonance imaging (MRI). OBJECTIVE: to validate the use of anthropometrics, including abdominal circumference and skinfold thickness (SFT ) measurements against MRI to predict SAT and VAT cross-sectional areas in persons with SCI DESIGN: Cross-sectional SETTING: Clinical research center PARTICIPANT: Twenty-two men with motor complete SCI METHODS: Anthropometric measurements and MRI were taken during a single visit...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29474974/structural-and-biophysical-insight-into-dual-site-binding-of-the-protoberberine-alkaloid-palmatine-to-parallel-g-quadruplex-dna-using-nmr-fluorescence-and-circular-dichroism-spectroscopy
#8
Kumar Padmapriya, Ritu Barthwal
Plant derived small molecules, which interact with and stabilize G-quadruplex DNA, act as inhibitors of telomere elongation and oncogene expression in humans. The inhibition of telomerase enzyme has immense potential since it is over expressed in most cancer cells. Interaction of palmatine, an antitumor alkaloid, to parallel G-quadruplex DNA, [d(TTGGGGT)]4 and [d(TTAGGGT)]4 , has been investigated using Nuclear Magnetic Resonance (NMR), fluorescence and Circular Dichroism (CD) spectroscopy. Titrations were monitored by recording1 H and31 P NMR spectra and solution structure of palmatine-[d(TTGGGGT)]4 complex was obtained by restrained Molecular Dynamics (rMD) simulations using distance restraints from 2D NOESY spectra...
February 20, 2018: Biochimie
https://www.readbyqxmd.com/read/29474883/newly-observed-anterior-thalamocortical-fiber-of-the-thalamus-with-7-0t-super-resolution-magnetic-resonance-tractogarphy-and-its-implication-for-the-classical-papez-circuit
#9
Sang-Han Choi, Young-Bo Kim, Zang-Hee Cho
Here, we have employed recently developed super-resolution tractography using 7.0T-MRI to analyze the fine structures involved in thalamocortical connections, something that has proved difficult using conventional techniques. We detail a newly observed thalamocortical pathway connecting the anterior nucleus of the thalamus and the cingulate cortex not via the internal capsule but via the septal area. The observed pathway is believed to be a classical pathway of the Papez circuit but had not been previously identified...
February 20, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29474882/the-angiographic-and-clinical-outcomes-of-intracranial-aneurysms-following-irradiation-in-patients-with-nasopharyngeal-carcinoma-a-13-year-experience-and-literature-review
#10
Chan Siang Hua Victor, Woo Yat Ming Peter, Wong Kai Sing Alain, Chan Kwong Yau, Leung Kar Ming
BACKGROUND AND PURPOSE: Intracranial aneurysms are a known but rare complication of radiotherapy (RT). We reviewed the angiographic and clinical outcomes of intracranial aneurysms following RT in patients with nasopharyngeal carcinoma (NPC), a malignancy endemic in Hong Kong. MATERIALS AND METHODS: The clinical, angiographic and laboratory data was collected for nine NPC patients harboring fifteen intracranial aneurysms following RT, diagnosed between 1st January 2000 and 31st December 2012...
February 20, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29474853/non-invasive-imaging-modalities-to-study-neurodegenerative-diseases-of-aging-brain
#11
REVIEW
Ramesh Naidu Annavarapu, Srujana Kathi, V Vamsi Krishna
The aim of this article is to highlight current approaches for imaging elderly brain, indispensable for cognitive neuroscience research with emphasis on the basic physical principles of various non-invasive neuroimaging techniques. The first part of this article presents a quick overview of the primary non-invasive neuroimaging modalities used by cognitive neuroscientists such as transcranial magnetic stimulation (TMS), transcranial electrical stimulation (tES), electroencephalography (EEG), magnetoencephalography (MEG), single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance spectroscopic imaging (MRSI), Profusion imaging, functional magnetic resonance imaging (fMRI), near infrared spectroscopy (NIRS) and diffusion tensor imaging (DTI) along with tractography and connectomics...
February 20, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29474744/contrast-in-cardiac-magnetic-resonance-imaging
#12
REVIEW
Nirav Patel, Pavani Kolakalapudi, Garima Arora
The utility and role of cardiac magnetic resonance (CMR) as a non-invasive diagnostic imaging modality has been well recognized in the field of cardiovascular disease. Use of late gadolinium enhancement (LGE) has further enhanced CMR's ability to determine structural, functional, and prognostic information in various cardiovascular diseases. The delivery and distribution of gadolinium as an extracellular agent allows the detection of edema, fibrosis, and infiltration in the myocardium. The pattern of LGE in cardiomyopathies enables us to distinguish among various disease processes non-invasively...
February 23, 2018: Echocardiography
https://www.readbyqxmd.com/read/29474665/catastrophizing-interferes-with-cognitive-modulation-of-pain-in-women-with-fibromyalgia
#13
Laura D Ellingson, Aaron J Stegner, Isaac J Schwabacher, Jacob B Lindheimer, Dane B Cook
Background: Pain modulation is a critical function of the nociceptive system that includes the ability to engage descending pain control systems to maintain a functional balance between facilitation and inhibition of incoming sensory stimuli. Dysfunctional pain modulation is associated with increased risk for chronic pain and is characteristic of fibromyalgia (FM). Catastrophizing is also common in FM. However, its influence on pain modulation is poorly understood. Objective: To determine the role of catastrophizing on central nervous system processing during pain modulation in FM via examining brain responses and pain sensitivity during an attention-distraction paradigm...
February 21, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29474544/invited-commentary-on-diagnostic-accuracy-of-postmortem-computed-tomography-magnetic-resonance-imaging-and-computed-tomography-guided-biopsies-for-the-detection-of-ischaemic-heart-disease-in-a-hospital-setting
#14
https://www.readbyqxmd.com/read/29474537/diagnostic-accuracy-of-postmortem-computed-tomography-magnetic-resonance-imaging-and-computed-tomography-guided-biopsies-for-the-detection-of-ischaemic-heart-disease-in-a-hospital-setting
#15
Ivo M Wagensveld, Britt M Blokker, Andrea Pezzato, Piotr A Wielopolski, Nomdo S Renken, Jan H von der Thüsen, Gabriel P Krestin, M G Myriam Hunink, J Wolter Oosterhuis, Annick C Weustink
Aims: The autopsy rate worldwide is alarmingly low (0-15%). Mortality statistics are important, and it is, therefore, essential to perform autopsies in a sufficient proportion of deaths. The imaging autopsy, non-invasive, or minimally invasive autopsy (MIA) can be used as an alternative to the conventional autopsy in an attempt to improve postmortem diagnostics by increasing the number of postmortem procedures. The aim of this study was to determine the diagnostic accuracy of postmortem magnetic resonance imaging (MRI), computed tomography (CT), and CT-guided biopsy for the detection of acute and chronic myocardial ischaemia...
February 20, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29474316/autoantibodies-against-n-methyl-d-aspartate-receptor-1-in-health-and-disease
#16
Hannelore Ehrenreich
PURPOSE OF REVIEW: Humoral autoimmunity has gained highest interest in neurology and psychiatry. Despite numerous recent articles on this hot topic, however, the biological significance of natural autoantibodies (AB) and the normal autoimmune repertoire of mammals remained quite obscure. AB may contribute to disorder-relevant phenotypes and are even believed to induce diseases themselves, but the circumstances under which AB become pathogenic are not fully understood. This review will focus on the highly frequent AB against the N-methyl-d-aspartate receptor 1 (NMDAR1-AB) as an illustrating example and provide a critical overview of current work (please note that the new nomenclature, GluN1, is disregarded here for consistency with the AB literature)...
February 22, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29474100/cervical-myelopathy-causing-numbness-and-paresthesias-in-lower-extremities-a-case-report-identifying-the-cause-of-a-false-positive-sharp-purser-test
#17
Cody J Mansfield
INTRODUCTION: The patient was referred to an outpatient physical therapy clinic for lumbar radiculopathy by a primary care physician and subsequently referred for imaging due to suspicion of cervical myelopathy. The case highlights the clinical reasoning of the physical therapist differentiating between lumbar stenosis, cervical myelopathy, and upper cervical instability. To the author's knowledge, this is the only case report in the literature to describe the mechanism that could underpin a false positive Sharp-Purser test (SPT)...
February 23, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29474081/the-nature-of-the-dielectric-response-of-methanol-revealed-by-the-terahertz-kerr-effect
#18
Tobias Kampfrath, R Kramer Campen, Martin Wolf, Mohsen Sajadi
The dielectric response of liquids in the terahertz (THz) and sub-THz frequency range arise from low-energy collective molecular motions, which are often strongly influenced by intermolecular interactions. To shed light on the microscopic origin of the THz dielectric response of the simplest alcohol, methanol, we resonantly excite this liquid with an intense THz electric-field pulse and monitor the relaxation of the induced optical birefringence. We find a unipolar THz Kerr-effect signal which, in contrast to aprotic polar liquids, shows a weak coupling between the THz electric field and the permanent molecular dipole moment...
February 23, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29474008/an-inverse-u-shaped-curve-of-resting-state-networks-in-individuals-at-high-risk-of-alzheimer-s-disease
#19
Qing Ye, Haifeng Chen, Fan Su, Hao Shu, Liang Gong, Chunming Xie, Hong Zhou, Feng Bai
OBJECTIVE: Higher functional connectivity (FC) in resting-state networks has been shown in individuals at risk of Alzheimer's disease (AD) by many studies. However, the longitudinal trajectories of the FC remain unknown. The present 35-month follow-up study aimed to explore longitudinal changes in higher FC in multiple resting-state networks in subjects with the apolipoprotein E ε4 allele (ApoE4) and/or amnestic mild cognitive impairment (aMCI). METHODS: Fifty-one subjects with aMCI and 64 cognitively normal (CN) subjects underwent neuropsychological tests and resting-state functional magnetic resonance imaging (fMRI) scans twice from April 2011 to June 2015...
February 20, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29473985/intracranial-vessel-wall-lesions-in-patients-with-systematic-lupus-erythematosus
#20
Satoru Ide, Shingo Kakeda, Mari Miyata, Shigeru Iwata, Naoaki Ohkubo, Shingo Nakayamada, Koichiro Futatsuya, Keita Watanabe, Junji Moriya, Yoshihisa Fujino, Yoshiya Tanaka, Yukunori Korogi
BACKGROUND: Systemic lupus erythematosus (SLE) is related to vasculitis, which causes brain infarctions; however, the pathology of large cerebral vessels has not been fully established. PURPOSE: To demonstrate the prevalence of vessel wall lesions (VWLs) in SLE patients using 3D vessel wall imaging and to assess the relationship between VWLs and brain infarctions. STUDY TYPE: Retrospective. SUBJECTS: Sixty SLE patients and 50 healthy subjects (HS)...
February 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
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