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https://www.readbyqxmd.com/read/29236342/longitudinal-assessment-of-rabbit-renal-fibrosis-induced-by-unilateral-ureteral-obstruction-using-two-dimensional-susceptibility-weighted-imaging
#1
Jing-Gang Zhang, Zhao-Yu Xing, Ting-Ting Zha, Xiao-Juan Tian, Ya-Nan Du, Jie Chen, Wei Xing
BACKGROUND: Previous studies indicated that two-dimensional-susceptibility weighted imaging (2D-SWI) could serve as a useful biomarker for differentiating the grade of liver fibrosis. PURPOSE: To evaluate the feasibility of 2D-SWI in the dynamic quantification of renal fibrosis in a rabbit model. STUDY TYPE: Longitudinal study. ANIMAL MODEL: Twenty-Four New Zealand White Rabbits including control group (n = 4); and renal fibrosis group (n = 20), by means of a unilateral ureteral obstruction (UUO) model...
December 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#2
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236273/prognosticating-hearing-outcome-in-patients-with-idiopathic-sudden-sensorineural-hearing-loss-by-means-of-otoacoustic-emissions-and-auditory-brainstem-response
#3
Masoud Motasaddi Zarandy, Mohammad Taghi Ashtiani, Shahin Bastaninejad, Sasan Dabiri Satri, Sevil Nasirmohtaram, Nourullah Agha Ebrahimi
This is an analytic-descriptive study, parallel with a randomized, controlled trial performed at Amir'Alam Hospital, a tertiary referral center, with the aim of evaluating the correlation between otoacoustic emission (OAE) and auditory brainstem response (ABR) findings with hearing outcome after treatment of idiopathic sudden sensorineural hearing loss (SSNHL). Sixty patients with idiopathic SSNHL who presented to the emergency services and otology clinics between 2012 and 2014, and whose symptoms had begun <10 days previously, enrolled in this study...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236232/%C3%AE-1%C3%A2-6-d-glucan-secreted-during-the-optimised-production-of-exopolysaccharides-by-paecilomyces-variotii-has-immunostimulatory-activity
#4
Erica F Osaku, Rafael A Menolli, Claudia R L de M Costa, Fernando Henrique G Tessaro, Renan H de Melo, Alex E do Amaral, Péricles A D Duarte, Arquimedes Paixão de Santana Filho, Andrea Caroline Ruthes, José Luis da C Silva, Rosiane G Mello
Paecilomyces variotii is a filamentous fungus that occurs worldwide in soil and decaying vegetation. Optimization of the fermentation process for exopolysaccharide (EPS) production from the fungus P. variotii, structure determination and immuno-stimulating activity of EPS were performed. Response surface methodology (RSM) coupled with central composite design (CCD) was used to optimize the physical and chemical factors required to produce EPS in submerged fermentation. Preliminary investigations to choose the three factors for the present work were made using a factorial experimental design...
December 13, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29236181/ultrasound-based-logistic-regression-model-lr2-versus-magnetic-resonance-imaging-for-discriminating-between-benign-and-malignant-adnexal-masses-a-prospective-study
#5
Kanane Shimada, Koji Matsumoto, Takashi Mimura, Tetsuya Ishikawa, Jiro Munechika, Yoshimitsu Ohgiya, Miki Kushima, Yusuke Hirose, Yuka Asami, Chiaki Iitsuka, Shingo Miyamoto, Mamiko Onuki, Hajime Tsunoda, Ryu Matsuoka, Kiyotake Ichizuka, Akihiko Sekizawa
BACKGROUND: The diagnostic performances of the International Ovarian Tumor Analysis (IOTA) ultrasound-based logistic regression model (LR2) and magnetic resonance imaging (MRI) in discriminating between benign and malignant adnexal masses have not been directly compared in a single study. METHODS: Using the IOTA LR2 model and subjective interpretation of MRI findings by experienced radiologists, 265 consecutive patients with adnexal masses were preoperatively evaluated in two hospitals between February 2014 and December 2015...
December 13, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29236171/uterine%C3%A2-fibroid-size-modifications-during-pregnancy-and-puerperium-evidence-from-the-first-systematic-review-of-literature
#6
REVIEW
Amerigo Vitagliano, Marco Noventa, Attilio Di Spiezio Sardo, Gabriele Saccone, Salvatore Gizzo, Shara Borgato, Salvatore Giovannni Vitale, Antonio Simone Laganà, Giovanni Battista Nardelli, Pietro Salvatore Litta, Carlo Saccardi
PURPOSE: The influence of pregnancy on uterine fibroid size still remains an unsolved dilemma. Basing on current knowledge, physicians are not able to inform patients about the likelihood of uterine fibroids to modify their size during pregnancy. Study aim was to summarize available evidence concerning the size modifications of uterine fibroids during each trimester of pregnancy and during puerperium. METHODS: The review was reported following the PRISMA guidelines and registered in PROSPERO (registration number: CRD42017071117)...
December 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29236169/current-treatment-of-central-retinal-artery-occlusion-a-national-survey
#7
Teddy S Youn, Patrick Lavin, Morgan Patrylo, Joseph Schindler, Howard Kirshner, David M Greer, Matthew Schrag
BACKGROUND: Central retinal artery occlusion (CRAO) is an ophthalmological emergency, the retinal analog of a stroke. To date there is no consensus or national guidelines on how this disorder should be managed. As academic neurologists and ophthalmologists treat CRAO frequently, we set out to understand how these clinicians approach patients with CRAO with a national survey. METHODS: We identified university-associated teaching hospitals offering vascular neurology, neuro-ophthalmology and/or retina fellowships in the US and asked the directors of the programs to respond to questions in an open response format to profile the acute management of CRAO at their institution...
December 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29236168/clinical-and-magnetic-resonance-imaging-features-of-elderly-onset-dentatorubral-pallidoluysian-atrophy
#8
Atsuhiko Sugiyama, Noriko Sato, Yasuhiro Nakata, Yukio Kimura, Mikako Enokizono, Tomoko Maekawa, Madoka Kondo, Yuji Takahashi, Satoshi Kuwabara, Hiroshi Matsuda
Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant spinocerebellar ataxia caused by CAG triplet expansion in atrophin 1 and is frequently associated with cerebral white matter lesions. To elucidate the clinical features of elderly onset DRPLA and the key radiological findings for differentiating DRPLA from physiological white matter lesions in healthy elderly subjects, we reviewed the clinical and magnetic resonance imaging (MRI) features of ten patients with elderly onset genetically confirmed DRPLA (> 60 years) and compared their MRI findings with those of age- and sex-matched ten healthy subjects with asymptomatic cerebral white matter lesions...
December 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29236114/stereodynamics-of-electron-induced-dissociative-ionization-of-n2-studied-by-e-e-ion-spectroscopy
#9
Noboru Watanabe, So Yamada, Masahiko Takahashi
We report an (e, e+ion) spectroscopy study on electron-induced dissociative ionization of N2. Vector correlation between the scattered electron and N+ ion has been measured for inner-valence ionization of N2 at an incident electron energy of 1.4 keV and scattering angles of 2.2°, 4.2°, and 8.2°. By analyzing the experimental data, partial ion yield spectra have been obtained for transitions to the C 2Σ, F 2Σ, and 2σ ion states, showing that the individual transitions depend on the momentum transferred to the target, K, in different ways...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29236074/morphological-and-optical-characteristics-of-chitosan-1-x-cuox-4-%C3%A2-x-%C3%A2-12-based-polymer-nano-composites-optical-dielectric-loss-as-an-alternative-method-for-tauc-s-model
#10
Shujahadeen B Aziz
In this work, copper (Cu) nanoparticles with observable surface plasmonic resonance (SPR) peaks were synthesized by an in-situ method. Chitosan host polymer was used as a reduction medium and a capping agent for the Cu nanoparticles. The surface morphology of the samples was investigated through the use of scanning electron micrograph (SEM) technique. Copper nanoparticles appeared as chains and white specks in the SEM images. The strong peaks due to the Cu element observed in the spectrum of energy dispersive analysis of X-rays...
December 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29236068/in-silico-screening-and-in-vitro-activity-measurement-of-javamide-analogues-as-potential-p38-mapk-inhibitors
#11
Jae B Park
p38 Mitogen-activated protein kinase (p38 MAPK) is a protein kinase critically involved in the progress of inflammation/stress-associated diseases. Our data suggested that javamide analogues may contain strong anti-inflammation activities, but there is little information about their effects on p38 MAPK. Therefore, in this paper, the effects of thirty javamide analogues on p38 MAPK were investigated using in silico screening and in vitro p38 MAPK assay methods. The javamide analogues were synthesized and their chemical structures were confirmed using nuclear magnetic resonance (NMR) spectroscopic methods...
December 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29235995/spin-dynamics-of-fega-sub-3-x-sub-ge-sub-x-sub-studied-by-electron-spin-resonance
#12
Bonho Koo, Kristian Bader, Ulrich Burkhardt, Michael Baenitz, Peter Gille, Jörg Sichelschmidt
The intermetallic semiconductor FeGa<sub>3</sub> acquires itinerant ferromagnetism upon electron doping by a partial replacement of Ga with Ge. We studied the electron spin resonance (ESR) of high-quality single crystals of FeGa<sub>3-x</sub>Ge<sub>x</sub> for x from 0 up to 0.162 where ferromagnetic order is observed. For x = 0 we observed a well-defined ESR signal, indicating the presence of pre-formed magnetic moments in the semiconducting phase. Upon Ge doping the occurrence of itinerant magnetism clearly affects the ESR properties below ≈ 40 K whereas at higher temperatures an ESR signal as seen in FeGa<sub>3</sub> prevails independent on the Ge-content...
December 13, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29235879/experimental-studies-on-artifacts-and-tumor-enhancement-on-gadoxetic-acid-enhanced-arterial-phase-liver-mri-in-a-rabbit-vx2-tumor-model
#13
Takahiro Tsuboyama, Gregor Jost, Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Hubertus Pietsch, Noriyuki Tomiyama
Background Rapid injection of gadoxetic acid is reported to produce more frequent artifacts and lower vascular enhancement on arterial phase liver magnetic resonance imaging (MRI). However, its effect on tumor enhancement and the mechanism of the artifacts remain unclear. Purpose To evaluate the effect of rapid injection of gadoxetic acid on artifacts and tumor enhancement during arterial phase liver MRI, and on arterial blood gases (ABGs) which may explain the cause of the artifacts. Material and Methods ABG analysis was performed in 13 free-breathing rabbits after rapid injection (1 mL/s; injection time = 0...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29235850/a-digital-protocol-for-chemical-analysis-at-ultra-low-concentrations-by-surface-enhanced-raman-scattering
#14
Carlos Diego L de Albuquerque, Regivaldo Gomes Sobral Filho, Ronei Jesus Poppi, Alexandre G Brolo
Single molecule surface-enhanced Raman Spectroscopy (SM-SERS) has the potential to revolutionize quantitative analysis at ultra-low concentrations (less than 1 nM). However, there are no established protocols to generalize the application of this technique in analytical chemistry. Here, a protocol for quantification at ultra-low concentrations using SM-SERS is proposed. The approach aims to take advantage of the stochastic nature of the single-molecule regime to achieved lower limits of detection (LOD) and quantification (LOQ)...
December 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29235846/cu-ii-doped-polydopamine-coated-gold-nanorods-for-tumor-theranostics
#15
Shuwei Liu, Lu Wang, Min Lin, Dandan Wang, Ziqi Song, Shuyao Li, Rui Ge, Xue Zhang, Yi Liu, Zhimin Li, Hongchen Sun, Bai Yang, Hao Zhang
Gold nanorods (AuNRs) are potentially useful in tumor theranostics, but the poor stability, high toxicity, and rapid removal by the immune system seriously limit their theranostic applications. In our study, we demonstrate the fabrication of Cu(II)-doped polydopamine-coated AuNR (AuNR@CuPDA), which significantly improves the potentials in tumor theranostics. Besides the improvement of physiological stability and biocompatibility, the PDA shell increases the photothermal performance and prolongs the blood circulation time of AuNRs...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235722/alterations-in-ventricular-pumping-in-patients-with-atrial-septal-defect-at-rest-during-dobutamine-stress-and-after-defect-closure
#16
Sigurdur S Stephensen, Ellen Ostenfeld, Katarina Steding-Ehrenborg, Ulf Thilén, Einar Heiberg, Hakan Arheden, Marcus Carlsson
BACKGROUND: Regional ventricular pumping mechanisms in patients with volume-loaded right ventricles (RV) are altered, but the cause is unknown. The aim was to determine whether these changes in ventricular pumping mechanisms are influenced by the RV dilatation itself or the aetiology behind it. METHODS: Seventeen patients with atrial septal defects (ASD) and 10 healthy controls underwent cardiovascular magnetic resonance (CMR) at rest and during dobutamine/atropine stress...
December 13, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29235608/extra-green-light-induced-zno-ultraviolet-lasing-enhancement-assisted-by-au-surface-plasmons
#17
F F Qin, C X Xu, Q X Zhu, J F Lu, D T You, W Xu, Z Zhu, A G Manohari, F Chen
We observed the dramatic enhancement of the intrinsic spontaneous and stimulated emission as well as the ensuing suppression of defect-related green emission in Au-decorated ZnO microrods. A series of spectral experiments and theoretical analysis demonstrated an electron transfer assisted process by surface plasmon (SP) resonant coupling between the Au nanoparticles and ZnO. The mechanism indicates an approach to enhance the UV emission of ZnO through an extra excitation of visible light similar to that for the defect emission of ZnO...
December 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29235485/quantification-of-interacting-cognate-odorants-with-olfactory-receptors-in-nanovesicles
#18
Marta Sanmartí-Espinal, Patrizia Iavicoli, Annalisa Calò, Marta Taulés, Roger Galve, M Pilar Marco, Josep Samitier
This study aims to improve our understanding of the interaction between olfactory receptors and odorants to develop highly selective biosensing devices. Natural nanovesicles (NVs) from Saccharomyces cerevisiae, ~100 nm in diameter, carrying either the human OR17-40 or the chimpanzee OR7D4 olfactory receptor (OR) tagged with the c-myc epitope at their N-terminus, are presented as model systems to quantify the interaction between odorant and olfactory receptors. The level of expression of olfactory receptors was determined at individual NVs using a novel competitive ELISA immunoassay comparing the values obtained against those from techniques involving the solubilization of cell membrane proteins and the identification of c-myc-carrying receptors...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235484/paper-based-mos2-nanosheet-mediated-fret-aptasensor-for-rapid-malaria-diagnosis
#19
Alisha Geldert, Kenry, Chwee Teck Lim
There has been growing interest in the development of paper-based biosensors because their simplicity and low cost are attractive for point-of-care diagnosis, especially in low-resource areas. However, only a limited range of paper materials - primarily chromatography papers - have been incorporated into diagnostics thus far. Here, we investigate the performance of different types of paper in order to develop an aptamer- and MoS2 nanosheet-based sensor relying on fluorescence resonance energy transfer (FRET) to signal the presence of a target protein...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235457/serum-metabolic-profile-alteration-reveals-response-to-platinum-based-combination-chemotherapy-for-lung-cancer-sensitive-patients-distinguished-from-insensitive-ones
#20
Shan Xu, Yanping Zhou, Hui Geng, Dandan Song, Jing Tang, Xianmin Zhu, Di Yu, Sheng Hu, Yanfang Cui
Most lung cancers are diagnosed at fairly advanced stages due to limited clinical symptoms. Platinum-based chemotherapy, either as single regimen or in combination with radiation, is one of the major recommendations for the patients. Earlier evaluation of the effectiveness of the chemotherapies is critical for developing better treatment plan given the toxicity of the chemotherapeutic reagents. Drug efficacy could be reflected in the systemic metabolism characteristics though knowledge about which remains scarce...
December 13, 2017: Scientific Reports
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