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Accent reduction

Marc N Gallay, David Moser, Franziska Rossi, Payam Pourtehrani, Anouk E Magara, Milek Kowalski, Alexander Arnold, Daniel Jeanmonod
BACKGROUND: Already in the late 1960s and early 1970s, targeting of the "posterior subthalamic area (PSA)" was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat patients suffering from essential tremor (ET). Recent advances in magnetic resonance (MR)-guided focused ultrasound (MRgFUS) technology offer the possibility to perform thermocoagulation of the cerebellothalamic fiber tract in the PSA without brain penetration, allowing a strong reduction of the procedure-related risks and increased accuracy...
2016: Journal of Therapeutic Ultrasound
Manish A Shah, Lindsay A Renfro, Carmen J Allegra, Thierry André, Aimery de Gramont, Hans-Joachim Schmoll, Daniel G Haller, Steven R Alberts, Greg Yothers, Daniel J Sargent
PURPOSE: Fluorouracil plus leucovorin (FU + LV) adjuvant chemotherapy reduced the risk of recurrence and death across all time points in a pooled analysis of 20,898 patients with colon cancer from 18 randomized studies. The impact of oxaliplatin added to FU + LV on the time course of recurrence and survival remains unknown. PATIENTS AND METHODS: A total of 12,233 patients enrolled to the randomized trials C-07, C-08, N0147, MOSAIC (Adjuvant Treatment of Colon Cancer), and XELOXA (Adjuvant XELOX) were pooled to examine the impact of oxaliplatin and tumor-specific factors on the time course of recurrence and death...
March 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Vineet Mishra, Lee Miller, Salman M S Alsaad, E Victor Ross
OBJECTIVE: To evaluate the efficacy of a fractional ablative micro-plasma radiofrequency (RF) device in the reduction of the appearance of abdominal striae. METHODS: Five female patients (age range, 30-60) with abdomen striae alba (n=4) and striae rubra (n=1) were enrolled in the study. Skin type distribution among the 5 patients was two type II, one type III, and two type IVs. The device (Accent XL, Alma Lasers Inc.) is a radiofrequency fractional platform (40...
November 2015: Journal of Drugs in Dermatology: JDD
Vladan P Čokić, Slavko Mojsilović, Aleksandra Jauković, Nada Kraguljac-Kurtović, Sonja Mojsilović, Dijana Šefer, Olivera Mitrović Ajtić, Violeta Milošević, Andrija Bogdanović, Dragoslava Đikić, Pavle Milenković, Raj K Puri
PURPOSE: We compared the gene expression profile of peripheral blood CD34(+) cells and granulocytes in subjects with chronic myeloid leukemia (CML), with the accent on signaling pathways affected by BCR-ABL oncogene. METHODS: The microarray analyses have been performed in circulating CD34(+) cells and granulocytes from peripheral blood of 7 subjects with CML and 7 healthy donors. All studied BCR-ABL positive CML patients were in chronic phase, with a mean value of 2012±SD of CD34(+)cells/μl in peripheral blood...
December 2015: Blood Cells, Molecules & Diseases
K Moens, A Dhollander, P Moens, K Verdonk, R Verdonk, K F Almqvist, J Victor
INTRODUCTION: The objective of this review is to give a state of affairs of meniscal transplantation, with the accent on preservation and surgical techniques. MATERIALS AND METHODS: All articles were selected by performing a search on the literature by using relevant keywords. The most relevant articles were selected with close attention to the publication date. RESULTS: When a meniscal tear is diagnosed, suture can be an option in the vascular zone, whereas the more frequently affected avascular zone heals poorly...
September 2014: Acta Orthopaedica Belgica
Susana Correia, Joseph Butler, Marina Vigário, Sónia Frota
Research on the perception of word stress suggests that speakers of languages with non-predictable or variable stress (e.g., English and Spanish) are more efficient than speakers of languages with fixed stress (e.g., French and Finnish) at distinguishing nonsense words contrasting in stress location. In addition, segmental and suprasegmental cues to word stress may also impact on the ability of speakers to perceive stress. European Portuguese (EP) is a language with variable stress and vowel reduction. Previous studies on EP have identified duration as the main cue for stress...
March 2015: Language and Speech
Sandesh Aryal, Ricardo Gutierrez-Osuna
This paper presents an articulatory synthesis method to transform utterances from a second language (L2) learner to appear as if they had been produced by the same speaker but with a native (L1) accent. The approach consists of building a probabilistic articulatory synthesizer (a mapping from articulators to acoustics) for the L2 speaker, then driving the model with articulatory gestures from a reference L1 speaker. To account for differences in the vocal tract of the two speakers, a Procrustes transform is used to bring their articulatory spaces into registration...
January 2015: Journal of the Acoustical Society of America
Fariba Jaffary, Mohammad Ali Nilforoushzadeh, Hajar Zarkoob
BACKGROUND: Radiofrequency (RF) is a new technique to treat facial wrinkles. This study was designed to assess the efficacy of Accent RF in wrinkle reduction of different areas of the face. MATERIALS AND METHODS: Patients with mild to severe facial wrinkles were treated with Accent using RF energies of 35-145 W. The average energy used in this study was 83.11 W. Patients received four subsequent weekly RF sessions. Wrinkle improvement was rated by two physicians comparing 6-month post treatment photographs with pretreatment photos...
November 2013: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Edgar Pick
The superoxide (O2 (∙-))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac. Under physiological conditions, in the resting phagocyte, O2 (∙-) generation is initiated by engagement of membrane receptors by a variety of stimuli, followed by specific signal transduction sequences leading to the translocation of the cytosolic components to the membrane and their association with the cytochrome...
2014: Methods in Molecular Biology
Freddy Cornillie, Stephen B Hanauer, Robert H Diamond, Jianping Wang, Kezhen L Tang, Zhenhua Xu, Paul Rutgeerts, Séverine Vermeire
BACKGROUND: Serum infliximab trough levels correlate with efficacy; dose escalation is often beneficial in patients with Crohn's disease who stop responding to infliximab treatment. OBJECTIVE: To carry out a post hoc analysis of A Crohn's Disease Clinical Trial Evaluating Infliximab in a New Long-term Treatment Regimen I (ACCENT I) to evaluate the association between serum infliximab trough levels and C-reactive protein (CRP) after 14 weeks of induction treatment with durable sustained long-term response (Crohn's Disease Activity Index decrease ≥70 points and reduction ≥25% from baseline)...
November 2014: Gut
Julie A Brent, Harisadhan Patra, Petula C Vaz
This study examined the effect of speakers' language background and noise on the perception of American English (AE) plosives. Six normal-hearing, young-adults volunteered for the study. Participants listened to speech tokens of six plosives, /p/, /b/, /t/, /d/, /k/, and /g/ in the initial, medial, and final positions in the context of three vowels, /a/, /i/, and /u/, spoken by native Bangladeshi Bengali (BB) and AE speakers. Tokens were presented at 45, 65, and 65 dB SPL, either in quiet or noise. Multitalker babble, speech noise, and 1000-2000 Hz, 2000-4000 Hz, and 500-5000 Hz noise bands were used as noise...
November 2013: Journal of the Acoustical Society of America
Megan T Stevens, Harisadhan Patra, Petula C Vaz
This study examined how native American English (AE) speakers perceived fricatives spoken by native AE and Bangladeshi Bengali (BB) speakers in quiet and noise. Participants included seven normal-hearing adults between 20 to 26 years of age. Participants listened to speech tokens of five fricatives, /s/, /z/, /ʃ/, /f/, and /v/ in the initial, medial, and final positions in the context of the point vowels /a/, /u/, /i/. Multitalker babble (MTB), speech noise, and three narrow bands of noise, 1000-2000 Hz, 2000-4000 Hz, and 500-5000 Hz at 45 dB SPL, 65 dB SPL and 85 dB SPL were used...
November 2013: Journal of the Acoustical Society of America
Ann R Bradlow, Lauren Ackerman, L Ann Burchfield, Lisa Hesterberg, Jenna Luque, Kelsey Mok
We motivate and present a corpus of scripted and spontaneous speech in both the native and the non-native language of talkers from various language backgrounds. Using corpus recordings from 11 native English and 11 late Mandarin-English bilinguals we compared speech timing across native English, native Mandarin, and Mandarin-accented English. Findings showed similarities across native Mandarin and native English in speaking rate and in reduction of the number of acoustic relative to orthographic syllables. The two languages differed in silence-to-speech ratio and in the number of words between pauses, possibly reflecting phrase-level structural differences between English and Mandarin...
2011: Proceedings of the ... International Congress of Phonetic Sciences
R Vacheva, M Todorova, A Decheva, N Yarakova, I Kraleva, Ts Takova, N Dimitrova, A Dobreva
The results achieved with 80% reduction in the incidence of early-onset neonatal group B streptococcal (GBS) sepsis following the implementation of the preliminary (1996, 2002) and subsequently the revised (2010) guidelines for intrapartum antibiotic prophylaxis imposed the discussion on a large scale of the updated:--algorithms for GBS screening (35-37 weeks of gestation) with the recommended dosage of penicillin-G for intrapartum antibiotic prophylaxis for women having normal labor and delivery;--algorithms for GBS screening and intrapartum antibiotic prophylaxis for women with preterm labor (PPROM) or premature rupture of membranes (PROM);--intrapartum antibiotic prophylaxis regimens for women with penicillin allergy;--algorithm for management of newborns with respect to risk of early-onset GBS disease...
2012: Akusherstvo i Ginekologii︠a︡
Frank A Sinicrope, Nathan R Foster, Greg Yothers, Al Benson, Jean Francois Seitz, Roberto Labianca, Richard M Goldberg, Aimery Degramont, Michael J O'Connell, Daniel J Sargent
BACKGROUND: Although obesity is an established risk factor for developing colon cancer, its prognostic impact and relation to patient sex in colon cancer survivors remains unclear. METHODS: The authors examined the prognostic and predictive impact of the body mass index (BMI) in patients with stage II and III colon carcinoma (N = 25,291) within the Adjuvant Colon Cancer Endpoints (ACCENT) database. BMI was measured at enrollment in randomized trials of 5-fluorouracil-based adjuvant chemotherapy...
April 15, 2013: Cancer
Jeremy Goslin, Hester Duffy, Caroline Floccia
This study used event-related potentials (ERPs) to examine whether we employ the same normalisation mechanisms when processing words spoken with a regional accent or foreign accent. Our results showed that the Phonological Mapping Negativity (PMN) following the onset of the final word of sentences spoken with an unfamiliar regional accent was greater than for those produced in the listener's own accent, whilst PMN for foreign accented speech was reduced. Foreign accents also resulted in a reduction in N400 amplitude when compared to both unfamiliar regional accents and the listener's own accent, with no significant difference found between the N400 of the regional and home accents...
August 2012: Brain and Language
Jay J Shen, Yu Xu, Anne L Bolstad, Margaret Covelli, Miriam Torpey, Roseann Colosimo
International nurses face a host of challenges in their transition and adaptation to the U.S. health care environment. Language and communication barriers have been ranked consistently as a top concern by employers, regulatory agencies, and international nurses themselves. Researchers in this study examined the effects of a 10-week linguistic class on the reduction of phonologic errors affecting foreign accent in a sample of international nurses. The linguistic course appeared to be effective in improving the international nurses' linguistic competence by reducing their phonologic errors significantly...
January 2012: Nursing Economic$
Vincent J van Heuven, Mirjam de Jonge
Although much has been written on the relative importance of acoustic correlates of linguistic stress for the listener, the role of spectral expansion/reduction has been much understudied. The present article is the first to study the role of spectral expansion/reduction in a two- parameter study together with temporal structure exploiting systematic variation of both parameters in a 7 × 7 stimulus space. We used a single minimal stress pair in Dutch, a language in which all classic acoustic correlates of stress were shown earlier to be relevant in single-parameter studies, i...
2011: Phonetica
Rahul Chakraborty, Ramalingam Shanmugam
The study explored the influence of second language proficiency on the kinematic duration of single words. Participants produced real and novel words with variable stress targets (e.g., trochaic and iambic) embedded in first language (L1) and second language (L2) sentence frames. Participants were monolingual English speakers (n=10) and Bengali-English bilinguals with early exposure to English (n=10) and late exposure to English (n=10). Bengali was the L1 and English was the L2 for all 20 bilingual participants...
December 2011: International Journal of Speech-language Pathology
Marta Ortega-Llebaria, Pilar Prieto
The general literature on the phonetic correlates of stress agrees that duration, and in stress accent languages, F0 are consistent correlates of stress. However, the role of amplitude changes in the speech signal is more controversial. In particular, the conflicting results of spectral tilt as a correlate of stress have been attributed to the effects of vowel reduction. We examined the stress correlates of duration, overall intensity and spectral tilt in Catalan and Spanish in both accented and unaccented contexts while controlling for formant frequency differences between morphologically corresponding vowels in stressed and unstressed environments by comparing vowels that maintain the same quality across stress contexts with those that do not...
March 2011: Language and Speech
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