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https://www.readbyqxmd.com/read/28320635/safety-and-efficacy-of-multipotent-adult-progenitor-cells-in-acute-ischaemic-stroke-masters-a-randomised-double-blind-placebo-controlled-phase-2-trial
#1
David C Hess, Lawrence R Wechsler, Wayne M Clark, Sean I Savitz, Gary A Ford, David Chiu, Dileep R Yavagal, Ken Uchino, David S Liebeskind, Alexander P Auchus, Souvik Sen, Cathy A Sila, Jeffrey D Vest, Robert W Mays
BACKGROUND: Multipotent adult progenitor cells are a bone marrow-derived, allogeneic, cell therapy product that modulates the immune system, and represents a promising therapy for acute stroke. We aimed to identify the highest, well-tolerated, and safest single dose of multipotent adult progenitor cells, and if they were efficacious as a treatment for stroke recovery. METHODS: We did a phase 2, randomised, double-blind, placebo-controlled, dose-escalation trial of intravenous multipotent adult progenitor cells in 33 centres in the UK and the USA...
March 17, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28320628/clinical-significance-of-contralateral-reactive-lesion-in-vocal-fold-polyp-and-cyst
#2
Jung-Hae Cho, Yong-Sug Choi, Young-Hoon Joo, Young-Hak Park, Dong-Il Sun
OBJECTIVE: We investigated the clinical significance of contralateral reactive lesions in patients undergoing laryngeal microsurgery for benign vocal fold lesions such as vocal polyps and cysts. STUDY DESIGN: This was a retrospective, single institution cohort study. METHODS: Patient medical records were reviewed for demographic characteristics; acoustic, aerodynamic, and perceptual analyses; and Voice Handicap Index score before and after laryngeal microsurgery...
March 17, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28320627/maximal-ambient-noise-levels-and-type-of-voice-material-required-for-valid-use-of-smartphones-in-clinical-voice-research
#3
Jean Lebacq, Jean Schoentgen, Giovanna Cantarella, Franz Thomas Bruss, Claudia Manfredi, Philippe DeJonckere
PURPOSE: Smartphone technology provides new opportunities for recording standardized voice samples of patients and transmitting the audio files to the voice laboratory. This drastically improves the achievement of baseline designs, used in research on efficiency of voice treatments. However, the basic requirement is the suitability of smartphones for recording and digitizing pathologic voices (mainly characterized by period perturbations and noise) without significant distortion. In a previous article, this was tested using realistic synthesized deviant voice samples (/a:/) with three precisely known levels of jitter and of noise in all combinations...
March 17, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28318967/pitch-strength-as-an-outcome-measure-for-treatment-of-dysphonia
#4
Lisa M Kopf, Cristina Jackson-Menaldi, Adam D Rubin, Jean Skeffington, Eric J Hunter, Mark D Skowronski, Rahul Shrivastav
BACKGROUND: Measurement of treatment outcomes is critical for the spectrum of voice treatments (ie, surgical, behavioral, or pharmacological). Outcome measures typically include visual (eg, stroboscopic data), auditory (eg, Consensus Auditory-Perceptual Evaluation of Voice; Grade, Roughness, Breathiness, Asthenia, Strain), and objective correlates of vocal fold vibratory characteristics, such as acoustic signals (eg, harmonics-to-noise ratio, cepstral peak prominence) or patient self-reported questionnaires (eg, Voice Handicap Index, Voice-Related Quality of Life)...
March 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28316174/-efficacy-and-safety-analysis-of-ivabradine-hydrochloride-treatment-of-chinese-patients-with-chronic-heart-failure-subgroup-analysis-of-chinese-patients-in-the-shift-study
#5
D Y Hu, D J Huang, Z Y Yuan, R P Zhao, X W Yan, M H Wang
Objective: To evaluate the efficacy and safety of ivabradine for the treatment of Chinese patients with chronic heart failure based on the Chinese subgroup data of the systolic heart failure treatment with the I(f) inhibitor ivabradine trial (SHIFT). Method: A total of 6 558 stable outpatients who presented symptoms of heart failure, with a left ventricular ejection fraction (LVEF) ≤35%, sinus rhythms with a heart rate ≥70 bpm participated in the randomized, double-blind, placebo-controlled, international multicenter clinical study...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28304110/perceptions-of-health-among-black-adults-living-in-a-diverse-urban-community
#6
Dahnika Sachs, Jill N Peltzer, Jerrihlyn L McGee
OBJECTIVE: The Robert Wood Johnson Foundation's culture of health initiative advocates for making health a shared value. Health cannot be a shared value without an understanding of how health is defined and perceived. The purpose of this qualitative descriptive study was to examine community members' perceptions of health and influencing factors, including health care services. DESIGN AND SAMPLE: Data were collected through a purposive sample of nine focus groups with 52 participants who were primarily Black (94%) and female (65%)...
March 17, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28303273/practice-patterns-of-speech-language-pathologists-in-pediatric-vocal-health
#7
Naomi A Hartley, Maia Braden, Susan L Thibeault
Purpose: The purpose of this study was to investigate current practices of speech-language pathologists (SLPs) in the management of pediatric vocal health, with specific analysis of the influence of clinical specialty and workplace setting on management approaches. Method: American Speech-Language-Hearing Association-certified clinicians providing services within the United States (1%-100% voice caseload) completed an anonymous online survey detailing clinician demographics; employment location and service delivery models; approaches to continuing professional development; and specifics of case management, including assessment, treatment, and discharge procedures...
March 16, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28301066/effect-of-daily-fraction-size-on-laryngoesophageal-dysfunction-after-chemoradiation-for-squamous-cell-carcinomas-of-the-larynx-and-hypopharynx
#8
Allen M Chen, Sophia Hsu, Jessica Meshman, Robert Chin, Philip Beron, Elliot Abemayor, Maie St John
BACKGROUND: The purpose of this study was to determine the effect of fraction size on laryngoesophageal dysfunction among patients treated by chemoradiotherapy for laryngeal and hypopharyngeal cancer. METHODS: Forty patients underwent chemoradiotherapy for stage III/IV squamous cell carcinomas of the larynx and hypopharynx. Median radiation dose was 70 Gy (range, 69.3-70.4 Gy) with daily fractionation ranging from 2 Gy to 2.2 Gy. RESULTS: When comparing 2 Gy versus >2 Gy daily fractionation, there was no difference in 2-year overall survival (71% vs 72%; p = ...
March 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28296055/efficacy-and-safety-of-saxagliptin-compared-with-acarbose-in-chinese-patients-with-type-2-diabetes-mellitus-uncontrolled-on-metformin-monotherapy-results-of-a-phase-iv-open-label-randomized-controlled-study-the-smart-study
#9
Jin Du, Li Liang, Hui Fang, Fengmei Xu, Wei Li, Liya Shen, Xueying Wang, Chun Xu, Fang Bian, Yiming Mu
AIM: To investigate the efficacy, safety and tolerability of saxagliptin compared with acarbose in Chinese patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin monotherapy. MATERIALS AND METHODS: SMART was a 24-week, multicentre, randomized, parallel-group, open-label Phase IV study conducted at 35 sites in China (24/09/2014-29/09/2015). The primary outcome was change from baseline in HbA1c at Week 24. Secondary efficacy outcomes assessed at Week 24 included the proportion of patients achieving HbA1c<7...
March 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28282475/a-cross-sectional-study-of-pain-among-u-s-college-music-students-and-faculty
#10
Jeremy L Stanek, Kevin D Komes, Fred A Murdock
OBJECTIVES: Studies over recent decades have demonstrated significant performance-related pain among professional musicians. However, there have been no largescale studies to evaluate pain among college musicians. The aim of this study was to determine the prevalence and anatomical locations of performance-related pain among students and faculty at the college level and learn what musicians do when they have pain. METHODS: Cross-sectional data were collected using an online survey distributed to colleges across the United States...
March 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/28277335/voice-and-swallowing-outcomes-for-adults-undergoing-reconstructive-surgery-for-laryngotracheal-stenosis
#11
Gemma M Clunie, Andrew J Kinshuck, Gurpreet S Sandhu, Justin W G Roe
PURPOSE OF REVIEW: Adult laryngotracheal stenosis is a rare, multifactorial condition which carries a significant physical and psychosocial burden. Surgical approaches have developed in recent years, however, voice and swallowing function can be affected prior to treatment, in the immediate postoperative phase, and as an ongoing consequence of the condition and surgical intervention. In this study we discuss: the nature of the problem; surgical interventions to address airway disorders; optimal patterns of care to maximize voice and swallowing outcomes...
March 8, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28277333/voice-outcomes-for-early-laryngeal-cancer
#12
Andrew J Kinshuck, Aditya Shenoy, Terry M Jones
PURPOSE OF REVIEW: Treatment options for early laryngeal cancer are well established with good local control and 5-year survival. The commonest treatments are radiotherapy or transoral laser microsurgery (TLM). There are advantages and disadvantages of the different modalities, but debate continues regarding the voice outcomes posttreatment. This review will focus on early glottic carcinoma and voice outcomes following the different treatments. RECENT FINDINGS: TLM and radiotherapy are both likely to affect voice quality, but the extent of voice change depends on different factors...
March 8, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28262500/cross-cultural-adaptation-and-validation-of-the-italian-version-of-the-voice-symptom-scale-i-voiss
#13
F Mozzanica, C Robotti, D Ginocchio, C Bulgheroni, R Lorusso, M Behlau, A Schindler, F Ottaviani
OBJECTIVES: To evaluate the reliability and validity of the Italian Voice Symptom Scale (I-VoiSS). STUDY DESIGN: Cross-sectional, nonrandomized, prospective study with controls. METHODS: The study consisted of five phases: item generation, reliability analysis, normative data generation, validity and responsiveness analysis. A group of 113 dysphonic patients was enrolled for the internal consistency analysis. Seventy-three of them completed the I-VoiSS twice, 2 weeks apart, for test-retest reliability analysis...
March 2, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28259606/multidimensional-assessment-of-the-effectiveness-of-group-voice-therapy
#14
Giovanna Cantarella, Sara Torretta, Silvia Ferruta, Annaclara Ciabatta, Claudia Manfredi, Lorenzo Pignataro, Philippe Dejonckere
OBJECTIVE: Group voice therapy has been successfully used in patients with dysphonia, but there is little objectively documented evidence of its effects on voice quality and the self-perception of voice fatigue. The aim of this study was to investigate the effectiveness of group therapy in patients with functional dysphonia and minor anatomic vocal fold pathologies linked by appearance and history to voice use in an objective and multidimensional manner. STUDY DESIGN: This is a prospective longitudinal study...
March 1, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28258804/efficacy-and-safety-of-adjunctive-steroid-injection-after-microsurgical-removal-of-benign-vocal-fold-lesions
#15
Jung-Hae Cho, Sang-Yeon Kim, Young-Hoon Joo, Young-Hak Park, Woo-Seob Hwang, Dong-Il Sun
OBJECTIVE: This study aims to investigate the clinical efficacy and safety of immediate intralesional steroid injection in patients undergoing laryngeal microsurgery (LMS) for benign vocal fold lesions (BVFLs). STUDY DESIGN: This is a single-institution, retrospective cohort study. METHODS: Patients were divided into two groups according to whether or not they received adjunctive steroid injection after LMS. We evaluated the outcomes using objective, perceptual voice analysis and videostroboscopy...
February 28, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28258685/-analysis-of-phonosurgical-methods-of-treatment-in-spasmodic-dysphonia
#16
Bożena Kosztyła-Hojna, Greta Berger, Maciej Zdrojkowski
Spasmodic dysphonia (SD) is rather a rare voice disorder. It is most often seen in woman aged 40-50. The disease is caused by deep emotional and neurological disorders of extrapyramidal system. Two main clinical forms of SD are distinguished: about 90% of cases - adductor spasmodic dysphonia and abductor spasmodic dysphonia roughly 10%. Conservative therapy does not always yield sufficient effects. Botulinum toxin - type A injections into the thyroarytenoid muscle are also used in therapy. Though results are temporary and reversible...
February 20, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28252585/-the-modern-approach-to-the-conservative-treatment-of-the-patients-presenting-with-postoperative-bilateral-vocal-fold-palsy
#17
O Yu Karpova, V M Svistushkin
The objective of the preset study was to further improve the diagnostics and treatment of unilateral palsies of the laryngeal recurrent nerves associated with transitory reflective spasm of the functionally competent vocal fold. The study included 49 patients (46 women and 3 men) at the age varying from 21 to 75 years presenting with unilateral palsies of the laryngeal recurrent nerves associated with transitory reflective spasm of the functionally competent vocal fold that developed after the surgical intervention on the thyroid gland...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28250512/political-commitment-for-vulnerable-populations-during-donor-transition
#18
Daniela C Rodríguez, Alan Whiteside, Sara Bennett
The responsibilities for the programmatic, technical and financial support of health programmes are increasingly being passed from external donors to governments. Programmes for family planning, human immunodeficiency virus, immunization, malaria and tuberculosis have already faced such donor transition, which is a difficult and often political process. Wherever programmes and services aimed at vulnerable populations are primarily supported by donors, the post-transition future is uncertain. Overreliance on donor support is often a reflection of limited domestic political commitment...
February 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28247251/giving-patients-preferences-a-voice-in-medical-treatment-life-cycle-the-prefer-public-private-project
#19
EDITORIAL
Esther W de Bekker-Grob, Conny Berlin, Bennett Levitan, Karim Raza, Kalliopi Christoforidi, Irina Cleemput, Jana Pelouchova, Harald Enzmann, Nigel Cook, Mats G Hansson
No abstract text is available yet for this article.
February 28, 2017: Patient
https://www.readbyqxmd.com/read/28244470/accelerated-versus-conventional-radiation-fractionation-in-early-stage-carcinoma-larynx
#20
M S Alam, R Perween, S A Siddiqui
INTRODUCTION: In our study, we have treated cases of early glottic carcinoma by two different dose-fractionation schedules in relation to overall treatment time. MATERIALS AND METHODS: This is an analysis of 29 patients with invasive, previously untreated T1and T2squamous cell carcinoma of true vocal cord that was treated by radical radiation therapy. DOSE AND FRACTIONATION: All patients were treated with a continuous course of radiation therapy with once-daily fractionation...
July 2016: Indian Journal of Cancer
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