keyword
https://read.qxmd.com/read/38546751/overexpression-of-transmembrane-phosphatase-with-tensin-homology-tpte-in-prostate-cancer-is-clinically-significant-suggesting-its-potential-as-a-valuable-biomarker
#1
JOURNAL ARTICLE
Nahid Zainodini, Maryam Abolhasani, Monireh Mohsenzadegan, Mohammad M Farajollahi, Elham Rismani
PURPOSE: Cancer testis antigens (CTAs) are a family of proteins typically expressed in male testicles but overexpressed in various cancer cell types. Transmembrane Phosphatase with Tensin homology (TPTE) is expressed only in the testis of healthy individuals and is a member of the family of CTAs. The current study, for the first time, examined the significance of TPTE expression in prostate cancer (PCa) tissues by generating a novel antibody marker targeting TPTE protein. METHODS: Polyclonal antibodies were prepared for TPTE-p1 and TPTE-p2 peptides, which are derived from the extracellular domains of TPTE...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38544672/chronic-demyelination-interferes-with-normal-spermatogenesis-in-cuprizone-intoxicant-c57-bl-6-mice-an-experimental-study
#2
JOURNAL ARTICLE
Arezoo Dorikhani, Ameneh Omidi, Mansoureh Movahedin, Iman Halvaei
BACKGROUND: Due to myelin and axonal insults in multiple sclerosis individuals, motor coordination problems and endocrine imbalance may develop. OBJECTIVE: This study aims to evaluate the role of chronic demyelination on the hypothalamic-pituitary-gonadal axis in the mouse model of multiple sclerosis. MATERIALS AND METHODS: 20 adult C57/BL6 male mice were divided into 2 groups (n = 10/each) as follows: the control group (CONT) received a regular diet for 17 wk; and the experimental group (cuprizone [CPZ]) was fed with 0...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38544670/sertoli-cell-conditioned-medium-can-improve-blood-testis-barrier-function-and-spermatogenesis-in-azoospermia-mice-induced-by-scrotal-hyperthermia-an-experimental-study
#3
JOURNAL ARTICLE
Fakhroddin Aghajanpour, Reza Soltani, Azar Afshar, Hojjat-Allah Abbaszadeh, Fatemeh Fadaei Fathabadi, Nafiseh Moeinian, Abbas Aliaghaei, Ali Dehghani Nejad, Reza Mastery Farahani, Mohsen Norouzian, Mohammad-Amin Abdollahifar
BACKGROUND: An increase in the temperature of the testis is associated with damage to the epithelium of seminiferous tubules and disruption of sperm production. OBJECTIVE: The current study aimed to investigate the effect of the Sertoli cell-conditioned medium (SCCM) on the blood-testis-barrier associated genes and spermatogenesis process following scrotal hyperthermia. MATERIALS AND METHODS: In this experimental study, 40 adult NMRI mice (8 wk, 25-30 gr) were allocated into 4 groups: I) control, II) DMEM (10 μl Dulbecco's Modified Eagle Medium), III) scrotal hyperthermia, and IV) scrotal hyperthermia+SCCM (10 μl SCCM)...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38543936/evaluation-of-a-combined-live-attenuated-vaccine-against-lumpy-skin-disease-contagious-bovine-pleuropneumonia-and-rift-valley-fever
#4
JOURNAL ARTICLE
Zohra Bamouh, Amal Elarkam, Soufiane Elmejdoub, Jihane Hamdi, Zineb Boumart, Greg Smith, Matthew Suderman, Mahder Teffera, Hezron Wesonga, Stephen Wilson, Douglas M Watts, Shawn Babiuk, Brad Pickering, Mehdi Elharrak
The use of effective vaccines is among the most important strategies for the prevention and progressive control of transboundary infectious animal diseases. However, the use of vaccine is often impeded by the cost, a lack of cold chains and other factors. In resource-limited countries in Africa, one approach to improve coverage and reduce cost is to vaccinate against multiple diseases using combined vaccines. Therefore, the objective of this study was to evaluate a combined vaccine for the prevention and control of Lumpy Skin Disease (LSD), Contagious Bovine Pleuropneumonia (CBPP) and Rift Valley fever (RVF)...
March 13, 2024: Vaccines
https://read.qxmd.com/read/38543637/transcriptomics-of-besnoitia-besnoiti-infected-fibroblasts-reveals-hallmarks-of-early-fibrosis-and-cancer-progression
#5
JOURNAL ARTICLE
María Fernández-Álvarez, Pilar Horcajo, Alejandro Jiménez-Meléndez, Pablo Angulo Lara, Ana Huertas-López, Francisco Huertas-López, Ignacio Ferre, Luis Miguel Ortega-Mora, Gema Álvarez-García
Endothelial injury, inflammatory infiltrate and fibrosis are the predominant lesions in the testis of bulls with besnoitiosis that may result in sterility. Moreover, fibroblasts, which are key players in fibrosis, are parasite target cells in a Besnoitia besnoiti chronic infection. This study aimed to decipher the molecular basis that underlies a drift toward fibrosis during the disease progression. Transcriptomic analysis was developed at two times post-infection (p.i.), representative of invasion (12 h p...
March 15, 2024: Microorganisms
https://read.qxmd.com/read/38543109/long-term-supplementation-of-royal-jelly-raydel-%C3%A2-improves-zebrafish-growth-embryo-production-and-survivability-blood-lipid-profile-and-functionality-of-vital-organs-a-72-weeks-consumption-study
#6
JOURNAL ARTICLE
Kyung-Hyun Cho, Hyo-Seon Nam, Ashutosh Bahuguna, Ji-Eun Kim
Royal jelly is a honeybee product with substantial pharmacological and health promotional activities. Nevertheless, the health implications associated with the prolonged dietary supplementation of royal jelly have yet to be elucidated extensively. Herein, 72 weeks of dietary supplementation of royal jelly at 5% and 10% ( w / w ) were investigated to assess the impact on zebrafish survivability, body weight, liver, testis, ovary functionality, and blood lipid profile. The results revealed no adverse effect of 72 weeks of royal jelly supplementation on zebrafish survivability...
March 1, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542118/roles-of-histone-h2a-variants-in-cancer-development-prognosis-and-treatment
#7
REVIEW
Po Man Lai, Kui Ming Chan
Histones are nuclear proteins essential for packaging genomic DNA and epigenetic gene regulation. Paralogs that can substitute core histones (H2A, H2B, H3, and H4), named histone variants, are constitutively expressed in a replication-independent manner throughout the cell cycle. With specific chaperones, they can be incorporated to chromatin to modify nucleosome stability by modulating interactions with nucleosomal DNA. This allows the regulation of essential fundamental cellular processes for instance, DNA damage repair, chromosomal segregation, and transcriptional regulation...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541782/expression-of-immunotherapy-target-prame-in-cancer-correlates-with-histone-h3-acetylation-and-is-unrelated-to-expression-of-methylating-dmnt3a-3b-and-demethylating-tet1-enzymes
#8
JOURNAL ARTICLE
Maciej Kaczorowski, Jerzy Lasota, Krzysztof Dudek, Bartosz Małkiewicz, Markku Miettinen, Agnieszka Hałoń
Background/Objectives: Preferentially expressed antigen in melanoma (PRAME), a member of the cancer testis antigen family, is a promising target for cancer immunotherapy. Understanding the epigenetic mechanisms involved in the regulation of PRAME expression might be crucial for optimizing anti-PRAME treatments. Methods: Three malignancies of different lineages (sinonasal melanoma, testicular seminoma, and synovial sarcoma), in which immunohistochemical (IHC) reactivity for PRAME is a common yet variable feature, were studied...
March 8, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541652/ras-mitogen-activated-protein-kinase-signaling-pathway-in-testicular-germ-cell-tumors
#9
REVIEW
Angelo Onorato, Eugenia Guida, Ambra Colopi, Susanna Dolci, Paola Grimaldi
Germ cell tumors (GCTs) are relatively rare tumors. However, they are the most diagnosed malignancies occurring in the testis among men aged between 15 and 40 years. Despite high aneuploidy and a paucity of somatic mutations, several genomic and transcriptomic assays have identified a few significantly mutated somatic genes, primarily KIT and K-RAS. The receptor Tyrosine Kinase (RTK) pathway and the downstream related Mitogen-Activated Protein Kinase (MAPK) cascades are crucial signal transduction pathways that preside over various cellular processes, including proliferation, differentiation, apoptosis, and responses to stressors...
February 29, 2024: Life
https://read.qxmd.com/read/38540740/ll-37-structures-antimicrobial-activity-and-influence-on-amyloid-related-diseases
#10
REVIEW
Surajit Bhattacharjya, Zhizhuo Zhang, Ayyalusamy Ramamoorthy
Antimicrobial peptides (AMPs), as well as host defense peptides (HDPs), constitute the first line of defense as part of the innate immune system. Humans are known to express antimicrobial precursor proteins, which are further processed to generate AMPs, including several types of α/β defensins, histatins, and cathelicidin-derived AMPs like LL37. The broad-spectrum activity of AMPs is crucial to defend against infections caused by pathogenic bacteria, viruses, fungi, and parasites. The emergence of multi-drug resistant pathogenic bacteria is of global concern for public health...
March 8, 2024: Biomolecules
https://read.qxmd.com/read/38539974/effect-of-day-length-on-growth-and-gonadal-development-in-meishan-male-pigs
#11
JOURNAL ARTICLE
Naisheng Lu, Hao Yuan, Xueyuan Jiang, Hulong Lei, Wen Yao, Peng Jia, Dong Xia
Day length is a critical environmental factor for regulating animal growth and development. This study aimed to investigate the effects of different day lengths on the developmental changes of growth parameters, testicular sizes, testosterone secretion in Meishan male pigs, and steroidogenesis proteins and melatonin receptors. Fourteen Meishan male pigs (10 weeks (wks) of age) with the same parity, paired in litter and body weight (BW), were evenly allocated into a short-day-length group (SDL, 10 light/14 dark) and long-day-length group (LDL, 14 light/10 dark)...
March 13, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539511/immune-checkpoint-inhibitors-and-male-fertility-should-fertility-preservation-options-be-considered-before-treatment
#12
REVIEW
Elissavet Ntemou, Emily Delgouffe, Ellen Goossens
In recent years, immune checkpoint inhibitors (ICIs) have become a viable option for many cancer patients, including specific subgroups of pediatric patients. Despite their efficiency in treating different types of cancer, ICIs are responsible for a number of immune-related adverse events, including inflammatory toxicities, that can affect several organs. However, our knowledge of the impact of ICIs on the testis and male fertility is limited. It is possible that ICI treatment affects testicular function and spermatogenesis either directly or indirectly (or both)...
March 17, 2024: Cancers
https://read.qxmd.com/read/38538714/mechanical-properties-of-native-and-decellularized-reproductive-tissues-insights-for-tissue-engineering-strategies
#13
JOURNAL ARTICLE
R Franko, Y Franko, E Ribes Martinez, G A Ferronato, I Heinzelmann, N Grechi, S Devkota, P K Fontes, R Coeti, T S I Oshiro, M A M M Ferraz
Understanding the mechanical properties and porosity of reproductive tissues is vital for regenerative medicine and tissue engineering. This study investigated the changes in Young's modulus (YM), storage modulus (E'), loss modulus (E"), and porosity of native and decellularized bovine reproductive tissues during the estrous cycle. Testis tunica albuginea had significantly higher YM, E', and E" than the inner testis, indicating greater stiffness and viscoelasticity. Endometrium showed no distinct differences in YM, E', or E" across the estrous cycle or between horns...
March 28, 2024: Scientific Reports
https://read.qxmd.com/read/38538087/effects-of-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-and-coronavirus-covid-19-vaccination-on-male-fertility
#14
JOURNAL ARTICLE
Fei Chen, Yunfei Zhang, Yingze Zhang, Yuqi Li, Jiao Ma, Yining Qin, Shuwen Deng, Yuhan Zhang, Deyang Wang, Haiying Wang, Juan Lin
Coronavirus disease 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains an ongoing global public health challenge. This disease causes damage not only to the respiratory system, affecting the normal physiological function of the lungs, but also to other vital organs, such as the heart and testicles. Existing studies have shown that co-expression of angiotensin-converting enzyme 2 and transmembrane serine protease 2 is the main mechanism by which SARS-CoV-2 invades host cells...
March 28, 2024: Sexual Health
https://read.qxmd.com/read/38537407/molybdenum-and-cadmium-co-induce-apoptosis-and-ferroptosis-through-inhibiting-nrf2-signaling-pathway-in-duck-anas-platyrhyncha-testes
#15
JOURNAL ARTICLE
Jiamei Zhu, Xueyan Dai, Yan Wang, Ting Cui, Bingyan Huang, Dianyun Wang, Wenjing Pu, Caiying Zhang
Cadmium (Cd) and high molybdenum (Mo) are injurious to the body. Previous research has substantiated that Cd and Mo exposure caused testicular injury of ducks, but concrete mechanism is not fully clarified. To further survey the toxicity of co-exposure to Cd and Mo in testis, 40 healthy 8-day-old Shaoxing ducks (Anas platyrhyncha) were stochasticly distributed to 4 groups and raised with basic diet embracing Cd (4 mg/kg Cd) or Mo (100 mg/kg Mo) or both. At the 16th wk, testis tissues were gathered. The characteristic ultrastructural changes related to apoptosis and ferroptosis were observed in Mo or Cd or both groups...
March 13, 2024: Poultry Science
https://read.qxmd.com/read/38536778/dmrt1-is-the-only-male-pathway-gene-tested-indispensable-for-sex-determination-and-functional-testis-development-in-tilapia
#16
JOURNAL ARTICLE
Shuangshuang Qi, Shengfei Dai, Xin Zhou, Xueyan Wei, Ping Chen, Yuanyuan He, Thomas D Kocher, Deshou Wang, Minghui Li
Sex is determined by multiple factors derived from somatic and germ cells in vertebrates. We have identified amhy, dmrt1, gsdf as male and foxl2, foxl3, cyp19a1a as female sex determination pathway genes in Nile tilapia. However, the relationship among these genes is largely unclear. Here, we found that the gonads of dmrt1;cyp19a1a double mutants developed as ovaries or underdeveloped testes with no germ cells irrespective of their genetic sex. In addition, the gonads of dmrt1;cyp19a1a;cyp19a1b triple mutants still developed as ovaries...
March 2024: PLoS Genetics
https://read.qxmd.com/read/38536015/bringing-proteomics-to-bear-on-male-fertility-key-lessons
#17
REVIEW
Rachel Parkes, Thomas X Garcia
INTRODUCTION: Male infertility is a major public health concern globally. Proteomics has revolutionized our comprehension of male fertility by identifying potential infertility biomarkers and reproductive defects. Studies comparing sperm proteome with other male reproductive tissues have the potential to refine fertility diagnostics and guide infertility treatment development. AREAS COVERED: This review encapsulates literature using proteomic approaches to progress male reproductive biology...
March 27, 2024: Expert Review of Proteomics
https://read.qxmd.com/read/38534338/-drosophila-importin-alpha-1-d%C3%AE-1-is-required-to-maintain-germline-stem-cells-in-the-testis-niche
#18
JOURNAL ARTICLE
James Heaney, Jiamin Zhao, Franca Casagranda, Kate L Loveland, Nicole A Siddall, Gary R Hime
Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 ( Dα1 ) null alleles in Drosophila and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche...
March 12, 2024: Cells
https://read.qxmd.com/read/38533178/genotoxicity-and-cytotoxicity-of-antineoplastic-drugs-at-environmentally-relevant-concentrations-after-long-term-exposure
#19
JOURNAL ARTICLE
P da Cunha de Medeiros, E A Nunes, G R M Barcelos, J E Perobelli
INTRODUCTION: 5-fluorouracil (5-FU) and methotrexate (MTX) are the antineoplastic drugs most commonly used worldwide. Considered cytotoxic, these pharmaceuticals exhibit low specificity, causing damage not only to cancer cells but also to healthy cells in organisms. After being consumed and metabolized, these drugs are excreted through urine and feces, followed by wastewater treatment. However, conventional treatments do not have the capacity to completely remove these substances, risking their introduction into freshwater systems...
April 2024: Toxicology Research
https://read.qxmd.com/read/38533024/bezafibrate-alleviates-diabetes-induced-spermatogenesis-dysfunction-by-inhibiting-inflammation-and-oxidative-stress
#20
JOURNAL ARTICLE
Yang Mu, Ling-Bo Luo, Shu-Juan Wu, Yue Gao, Xiao-Lin Qin, Jing Zhao, Qian Liu, Jing Yang
The metabolic disorders caused by diabetes can lead to various complications, including male spermatogenesis dysfunction. Exploring effective therapeutics that attenuate diabetes mellitus (DM)-induced male subfertility is of great importance. Pharmaceuticals targeting PPARα activation such as bezafibrate have been regarded as an important strategy for patients with diabetes. In this study, we use streptozocin (STZ) injection to establish a type 1 DM mice model and use bezafibrate to treat DM mice and evaluate the effects of bezafibrate on the spermatogenic function of the DM male mice...
March 30, 2024: Heliyon
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