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https://www.readbyqxmd.com/read/29234730/spontaneous-superior-mesenteric-artery-branch-pseudoaneurysm-a-rare-case-report
#1
Mina Guirgis, Jema Hua Xu, Alar Kaard, Bibombe P Mwipatayi
Background: Visceral arterial pseudoaneurysms (VAPAs) are rare vascular entities with serious consequences. Traditionally, they are associated with trauma, infection, and inflammatory disease, or they can arise as a post-operative complication. Report: An 87 year old man presented with abdominal pain and was found to have a spontaneous VAPA on a computed tomography angiogram. Serial imaging 4 months previously had demonstrated no aneurysm. Between scans, warfarin was changed to apixaban for aortic valve replacement, but he had no other changes to any other medications...
2017: EJVES Short Reports
https://www.readbyqxmd.com/read/29205554/vapa-of-rhodococcus-equi-binds-phosphatidic-acid
#2
Lindsay M Wright, Emily M Carpinone, Terry L Bennett, Mary K Hondalus, Vincent J Starai
Rhodococcus equi is a multi-host, facultative intracellular bacterial pathogen that primarily causes pneumonia in foals less than six months in age and immunocompromised people. Previous studies determined that the major virulence determinant of R. equi is the surface bound virulence associated protein A (VapA). The presence of VapA inhibits the maturation of R. equi-containing phagosomes and promotes intracellular bacterial survival, as determined by the inability of vapA deletion mutants to replicate in host macrophages...
December 4, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29164308/endovascular-repair-of-40-visceral-artery-aneurysms-and-pseudoaneurysms-with-the-viabahn-stent-graft-technical-aspects-clinical-outcome-and-mid-term-patency
#3
Massimo Venturini, Paolo Marra, Michele Colombo, Marta Panzeri, Simone Gusmini, Claudio Sallemi, Marco Salvioni, Carolina Lanza, Giulia Agostini, Gianpaolo Balzano, Yamume Tshomba, Germano Melissano, Massimo Falconi, Roberto Chiesa, Francesco De Cobelli, Alessandro Del Maschio
PURPOSE: Endovascular repair of true visceral artery aneurysms (VAAs) and pseudoaneurysms (VAPAs) with stent-grafting (SG) can simultaneously allow aneurysm exclusion and vessel preservation, minimizing the risk of ischemic complications. Our aim was to report a single-center experience on SG of visceral aneurysms, focusing on technical aspects, clinical outcome and mid-term patency. MATERIALS AND METHODS: Consecutive patients affected by VAAs-VAPAs and submitted to endovascular treatment were retrospectively reviewed, and SG cases with the self-expandable peripheral Viabahn stent-graft were analyzed (2003-2017)...
November 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29148593/first-isolation-of-vibrio-tapetis-and-an-atypical-strain-of-aeromonas-salmonicida-from-skin-ulcerations-in-common-dab-limanda-limanda-in-the-north-sea
#4
M Vercauteren, E De Swaef, A Declercq, L Bosseler, S Gulla, S Balboa, J L Romalde, L Devriese, H Polet, F Boyen, K Chiers, A Decostere
Skin ulcerations rank amongst the most prevalent lesions affecting wild common dab (Limanda limanda) with an increase in prevalence of up to 3.5% in the Belgian part of the North Sea. A complex aetiology of these ulcerations is suspected, and many questions remain on the exact factors contributing to these lesions. To construct the aetiological spectrum of skin ulcerations in flatfish, a one-day monitoring campaign was undertaken in the North Sea. Fifteen fish presented with one or more ulcerations on the pigmented and/or non-pigmented side...
November 17, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29137428/pten-loss-is-associated-with-prostate-cancer-recurrence-and-alterations-in-tumor-dna-methylation-profiles
#5
Milan S Geybels, Min Fang, Jonathan L Wright, Xiaoyu Qu, Marina Bibikova, Brandy Klotzle, Jian-Bing Fan, Ziding Feng, Elaine A Ostrander, Peter S Nelson, Janet L Stanford
Background: Prostate cancer (PCa) with loss of the tumor suppressor gene PTEN has an unfavorable prognosis. DNA methylation profiles associated with PTEN loss may provide further insights into the mechanisms underlying these more aggressive, clinically relevant tumors. Methods: The cohort included patients with clinically localized PCa. Samples taken from the primary tumor were used to determine PTEN genomic deletions using FISH, and to analyze epigenome-wide DNA methylation profiles...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049183/identifying-key-genes-associated-with-acute-myocardial-infarction
#6
Ming Cheng, Shoukuan An, Junquan Li
BACKGROUND: This study aimed to identify key genes associated with acute myocardial infarction (AMI) by reanalyzing microarray data. METHODS: Three gene expression profile datasets GSE66360, GSE34198, and GSE48060 were downloaded from GEO database. After data preprocessing, genes without heterogeneity across different platforms were subjected to differential expression analysis between the AMI group and the control group using metaDE package. P < .05 was used as the cutoff for a differentially expressed gene (DEG)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28868569/genetic-analysis-of-12-x-str-loci-in-the-serbian-population-from-vojvodina-province
#7
Igor Veselinović, Dušan Vapa, Mihajla Djan, Nevena Veličković, Tanja Veljović, Galina Petrić
The analysis of 12 X-STR loci included in the Investigator® Argus X-12 kit was performed on a sample of 325 unrelated persons from Vojvodina Province, Republic of Serbia. No significant differences were observed in the allele frequencies in males and females. Heterozygosity values among the studied loci ranged from 67.62 to 94.28%. All loci in female individuals were consistent with the Hardy-Weinberg equilibrium test. The combined power of discrimination values in male and female individuals was 0.9999999994 and 0...
September 3, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28698274/noroviruses-co-opt-the-function-of-host-proteins-vapa-and-vapb-for-replication-via-a-phenylalanine-phenylalanine-acidic-tract-motif-mimic-in-nonstructural-viral-protein-ns1-2
#8
Broc T McCune, Wei Tang, Jia Lu, James B Eaglesham, Lucy Thorne, Anne E Mayer, Emily Condiff, Timothy J Nice, Ian Goodfellow, Andrzej M Krezel, Herbert W Virgin
The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals. The human norovirus nonstructural protein NS1/2 interacts with the host protein VAMP-associated protein A (VAPA), but the significance of the NS1/2-VAPA interaction is unexplored. Here we report decreased murine norovirus replication in VAPA- and VAPB-deficient cells. We characterized the role of VAPA in detail...
July 11, 2017: MBio
https://www.readbyqxmd.com/read/28690290/rescue-of-an-intracellular-avirulent-rhodococcus-equi-replication-defect-by-the-extracellular-addition-of-virulence-associated-protein-a
#9
Nuttapone Sangkanjanavanich, Masanori Kawai, Tsutomu Kakuda, Shinji Takai
Rhodococcus equi is a facultative intracellular bacterium that can escape from bactericidal mechanisms associated with phagocytosis. Virulence-associated protein A (VapA), encoded on a virulence-associated plasmid, is essential for intracellular survival in macrophages, but its function is not known. Here, we show that the extracellular addition of recombinant glutathione S-transferase (GST)-VapA fusion protein rescued the intracellular replication defect of a mutant lacking the vapA gene. Furthermore, the virulence-plasmid-cured strain could also multiply to nearly wild-type levels by the addition of GST-VapA...
August 4, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28659059/endovascular-treatment-of-visceral-artery-aneurysms-and-pseudoaneurysms-in-100-patients-covered-stenting-vs-transcatheter-embolization
#10
Massimo Venturini, Paolo Marra, Michele Colombo, Marco Alparone, Giulia Agostini, Luca Bertoglio, Claudio Sallemi, Marco Salvioni, Simone Gusmini, Gianpaolo Balzano, Renata Castellano, Luca Aldrighetti, Yamume Tshomba, Massimo Falconi, Germano Melissano, Francesco De Cobelli, Roberto Chiesa, Alessandro Del Maschio
PURPOSE: To retrospectively report a large single-center experience of visceral artery aneurysms (VAAs) and pseudoaneurysms (VAPAs) treated with covered stenting (CS) as the first therapeutic option vs transcatheter embolization (TE). METHODS: One hundred patients (mean age 59±14 years; 58 men) underwent 59 elective and 41 emergent endovascular procedures to treat 51 VAAs and 49 VAPAs. Seventy patients had TE and 30 received CS (27 Viabahn and 3 coronary stent grafts)...
June 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28642343/differential-distribution-of-vapa-positive-rhodococcus-equi-in-affected-and-unaffected-horse-breeding-farms
#11
S Petry, C Sévin, M A Fleury, F Duquesne, N Foucher, C Laugier, M Henry-Amar, J Tapprest
No abstract text is available yet for this article.
June 22, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28553279/vaccination-of-mice-with-virulence-associated-protein-g-vapg-antigen-confers-partial-protection-against-rhodococcus-equi-infection-through-induced-humoral-immunity
#12
Marcel M Trevisani, Ebert S Hanna, Aline F Oliveira, Silvia A Cardoso, Maria C Roque-Barreira, Sandro G Soares
Rhodococcus equi is a facultative intracellular bacterium causing severe pyogranulomatous pneumonia, ulcerative enterocolitis, and mesenteric lymphadenopathy in foals aged less than 6 months. Less frequently, this pathogen affects various other species, such as pigs, cattle, cats, and even humans. Although rhodococcosis is treated with a combination of antimicrobial agents, resistance is developed in some cases, and thus, antimicrobial susceptibility must be monitored and managed. Considering these limitations of the current therapy and unavailability of a vaccine to prevent the disease, research is particularly focused on the development of an effective vaccine against rhodococcosis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28279794/involvement-of-luxs-in-aeromonas-salmonicida-metabolism-virulence-and-infection-in-atlantic-salmon-salmo-salar-l
#13
Lingjie Meng, Yishuai Du, Pengfei Liu, Xian Li, Ying Liu
Quorum sensing is a bacterial density dependent communication system, which regarded to regulate co-operative behaviors of community and mediated by extracellular signal molecules named autoinducers (AI). Among various signals, autoinducer-2 (AI-2) is believed to be the messengers inter species and produced by LuxS. For Aeromonas salmonicida (A. salmonicida), an opportunistic pathogen to many cold-water teleost, little information has been known about the function of AI-2 and LuxS. Therefore, our aim was to preliminarily clarify the function of LuxS in A...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28149575/veno-venous-extracorporeal-membrane-oxygenation-cannulation-techniques
#14
REVIEW
Carlo Banfi, Matteo Pozzi, Nils Siegenthaler, Marie-Eve Brunner, Didier Tassaux, Jean-Francois Obadia, Karim Bendjelid, Raphaël Giraud
The development of extracorporeal membrane oxygenation (ECMO) technology allows a new approach for the intensive care management of acute cardiac and/or respiratory failure in adult patients who are not responsive to conventional treatment. Current ECMO therapies provide a variety of options for the multidisciplinary teams who are involved in the management of these critically ill patients. In this regard, veno-venous ECMO (VV-ECMO) can provide quite complete respiratory support, even if this highly complex technique presents substantial risks, such as bleeding, thromboembolic events and infection...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28124475/genome-wide-two-locus-interaction-analysis-identifies-multiple-epistatic-snp-pairs-that-confer-risk-of-prostate-cancer-a-cross-population-study
#15
Jiawei Shen, Zhiqiang Li, Zhijian Song, Jianhua Chen, Yongyong Shi
Prostate cancer is one of the most common carcinomas among adult males. Recently, genome-wide association studies (GWAS) have identified several susceptibility genes of prostate cancer. However, these single locus results can only explain a small proportion of the genetic etiology. In order to understand how multiple genetic variants may contribute to the penetrance of prostate cancer, we conducted a genome-wide SNP-SNP interaction study in four populations, involving 5,269 cases and 5,289 controls. We exhaustively evaluated all pairs of SNP-SNP interactions for 661,658 SNPs that were consensus in all four groups, and then performed a meta-analysis to combine the results...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28122544/molecular-characterization-of-rhodococcus-equi-isolates-from-horses-in-poland-pvapa-characteristics-and-plasmid-new-variant-85-kb-type-v
#16
Lucjan Witkowski, Magdalena Rzewuska, Shinji Takai, Dorota Chrobak-Chmiel, Magdalena Kizerwetter-Świda, Małgorzata Feret, Marta Gawryś, Maciej Witkowski, Jerzy Kita
BACKGROUND: Rhodococcus equi is one of the most significant bacterial pathogens affecting foals up to 6 months of age worldwide. Rhodococcosis is present in Poland however information about molecular characterization of R. equi isolates is scarce. This study describes molecular characterization of Rhodococcus equi infection on 13 horse breeding farms in Poland between 2001 and 2012. Samples were collected by tracheobronchial aspiration from pneumonic foals or during necropsy. The R. equi isolates were genotyped by plasmid profiling and pulsed-field gel electrophoresis...
January 26, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28108527/incredibly-close-a-newly-identified-peroxisome-er-contact-site-in-humans
#17
COMMENT
Maya Schuldiner, Einat Zalckvar
Peroxisomes are tiny organelles that control important and diverse metabolic processes via their interplay with other organelles, including the endoplasmic reticulum (ER). In this issue, Costello et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607055) and Hua et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608128) identify a peroxisome-ER contact site in human cells held together by a tethering complex of VAPA/B (vesicle-associated membrane protein-associated proteins A/B) and ACBD5 (acyl Co-A binding protein 5)...
February 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28108526/vaps-and-acbd5-tether-peroxisomes-to-the-er-for-peroxisome-maintenance-and-lipid-homeostasis
#18
Rong Hua, Derrick Cheng, Étienne Coyaud, Spencer Freeman, Erminia Di Pietro, Yuqing Wang, Adriano Vissa, Christopher M Yip, Gregory D Fairn, Nancy Braverman, John H Brumell, William S Trimble, Brian Raught, Peter K Kim
Lipid exchange between the endoplasmic reticulum (ER) and peroxisomes is necessary for the synthesis and catabolism of lipids, the trafficking of cholesterol, and peroxisome biogenesis in mammalian cells. However, how lipids are exchanged between these two organelles is not understood. In this study, we report that the ER-resident VAMP-associated proteins A and B (VAPA and VAPB) interact with the peroxisomal membrane protein acyl-CoA binding domain containing 5 (ACBD5) and that this interaction is required to tether the two organelles together, thereby facilitating the lipid exchange between them...
February 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/27865011/vital-signs-as-predictors-for-aggression-in-hospital-patients-vapa
#19
Julie Considine, Debra Berry, Rebecca Johnson, Natisha Sands
AIMS AND OBJECTIVES: To examine and describe the relationship between physiological status and violent and aggressive behaviours in hospital patients. BACKGROUND: The majority of adverse events are preceded by physiological abnormalities; whether physiological deterioration is a predictor of violent or aggressive behaviours remains unknown. DESIGN: Prospective case-control study. METHODS: Prospective audit of 999 patients from two major health services in Melbourne, Australia...
November 16, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27762083/the-rhodococcus-equi-virulence-protein-vapa-disrupts-endolysosome-function-and-stimulates-lysosome-biogenesis
#20
Adam P Rofe, Luther J Davis, Jean L Whittingham, Elizabeth C Latimer-Bowman, Anthony J Wilkinson, Paul R Pryor
Rhodococcus equi (R. equi) is an important pulmonary pathogen in foals that often leads to the death of the horse. The bacterium harbors a virulence plasmid that encodes numerous virulence-associated proteins (Vaps) including VapA that is essential for intracellular survival inside macrophages. However, little is known about the precise function of VapA. Here, we demonstrate that VapA causes perturbation to late endocytic organelles with swollen endolysosome organelles having reduced Cathepsin B activity and an accumulation of LBPA, LC3 and Rab7...
April 2017: MicrobiologyOpen
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