Jennifer Soto, Yang Song, Yifan Wu, Binru Chen, Hyungju Park, Navied Akhtar, Peng-Yuan Wang, Tyler Hoffman, Chau Ly, Junren Sia, SzeYue Wong, Douglas O Kelkhoff, Julia Chu, Mu-Ming Poo, Timothy L Downing, Amy C Rowat, Song Li
The role of transcription factors and biomolecules in cell type conversion has been widely studied. Yet, it remains unclear whether and how intracellular mechanotransduction through focal adhesions (FAs) and the cytoskeleton regulates the epigenetic state and cell reprogramming. Here, it is shown that cytoskeletal structures and the mechanical properties of cells are modulated during the early phase of induced neuronal (iN) reprogramming, with an increase in actin cytoskeleton assembly induced by Ascl1 transgene...
June 26, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)