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James Wever-Pinzon, Craig H Selzman, Greg Stoddard, Omar Wever-Pinzon, Anna Catino, Abdallah G Kfoury, Nikolaos A Diakos, Bruce B Reid, Stephen McKellar, Michael Bonios, Antigone Koliopoulou, Deborah Budge, Aaron Kelkhoff, Josef Stehlik, James C Fang, Stavros G Drakos
BACKGROUND: Small-scale studies focused mainly on nonischemic cardiomyopathy (NICM) have shown that a subset of left ventricular assist device (LVAD) patients can achieve significant improvement of their native heart function, but the impact of ischemic cardiomyopathy (ICM) has not been specifically investigated. Many patients with acute myocardial infarction are discharged from their index hospitalization without heart failure (HF), only to return much later with overt HF syndrome, mainly caused by chronic remodeling of the noninfarcted region of the myocardium...
October 18, 2016: Journal of the American College of Cardiology
Mohammad Al-Sarie, Asad Rauf, Abdallah G Kfoury, Anna Catino, James Wever-Pinzon, Michael Bonios, Benjamin D Horne, Nikolaos A Diakos, Omar Wever-Pinzon, Stephen H McKellar, Aaron Kelkhoff, Lauren McCreath, James Fang, Josef Stehlik, Craig H Selzman, Stavros G Drakos
OBJECTIVES: The aim of this study was to assess the impact of continuous-flow left ventricular assist device (LVAD) type-axial flow (AX) versus centrifugal flow (CR)-on myocardial structural and functional response following mechanical unloading. BACKGROUND: The use of continuous-flow LVADs is increasing steadily as a therapeutic option for patients with end-stage heart failure who are not responsive to medical therapy. Whether the type of mechanical unloading influences the myocardial response is yet to be determined...
July 2016: JACC. Heart Failure
D W Weisgerber, D O Kelkhoff, S R Caliari, B A C Harley
Orthopedic interfaces such as the tendon-bone junction (TBJ) present unique challenges for biomaterials development. Here we describe a multi-compartment collagen-GAG scaffold fabricated via lyophilization that contains discrete mineralized (CGCaP) and non-mineralized (CG) regions joined by a continuous interface. Modifying CGCaP preparation approaches, we demonstrated scaffold variants of increasing mineral content (40 vs. 80wt% CaP). We report the impact of fabrication parameters on microstructure, composition, elastic modulus, and permeability of the entire multi-compartment scaffold as well as discrete mineralized and non-mineralized compartments...
December 2013: Journal of the Mechanical Behavior of Biomedical Materials
Latha Achanta, Aaron J Kelkhoff
No abstract text is available yet for this article.
January 2013: Journal of the Arkansas Medical Society
Francis Lam, Chase Ransom, Jeffrey M Gossett, Aaron Kelkhoff, Paul M Seib, Michael L Schmitz, Janet C Bryant, Elizabeth A Frazier, Punkaj Gupta
This retrospective observational study aimed to evaluate the safety and efficacy of dexmedetomidine (DEX) for children with heart failure. The study was conducted in the cardiovascular intensive care unit (CVICU) of a single, tertiary care, academic children's hospital. A retrospective review of the charts for all children (up to 18 years of age) with signs and symptoms consistent with congestive heart failure who received DEX in our CVICU between April 2006 and April 2011 was performed. The patients were divided into two groups for study purposes: the DEX group of 21 patients, who received a DEX infusion together with other conventional sedation agents, and the control group of 23 patients, who received conventional sedation agents without the use of DEX...
April 2013: Pediatric Cardiology
Emily A Gonnerman, Douglas O Kelkhoff, Lisa M McGregor, Brendan A C Harley
Biomaterials for myocardial tissue engineering must balance structural, mechanical and bioactivity concerns. This work describes the interaction between HL-1 cardiomyocytes and a series of geometrically anisotropic collagen-GAG (CG) scaffolds with aligned tracks of ellipsoidal pores designed to mimic elements of the native geometric anisotropy of cardiac tissue. Here we report the role scaffold geometric anisotropy and pore size plays in directing cardiomyocyte bioactivity. Notably, HL-1 cardiomyocytes showed good proliferation and metabolic activity in all variants out to 14 days in culture...
December 2012: Biomaterials
Bradley A Thuro, Aaron J Kelkhoff, John D Pemberton
Complications with the Ritleng probe have not been reported previously. Herein, we report a case in which the Ritleng probe tip fractured during use on a patient undergoing nasolacrimal duct intubation requiring subsequent retrieval. A root-cause analysis was conducted which help to elicit possible ways to prevent such a complication in the future. Most notably the use of the stylet, documented as a cleaning device, seems to offer additional support to prevent metal fatigue and tip fracture.
January 2013: Ophthalmic Plastic and Reconstructive Surgery
Steven R Caliari, Daniel W Weisgerber, Manuel A Ramirez, Douglas O Kelkhoff, Brendan A C Harley
Biomaterials for orthopedic tissue engineering must balance mechanical and bioactivity concerns. This work describes the fabrication of a homologous series of anisotropic collagen-GAG (CG) scaffolds with aligned tracks of ellipsoidal pores but increasing relative densities (ρ(∗)/ρ(s)), and we report the role scaffold relative density plays in directing tenocyte bioactivity. Scaffold permeability and mechanical properties, both in tension and compression, were significantly influenced by relative density in a manner predicted by cellular solids models...
July 2012: Journal of the Mechanical Behavior of Biomedical Materials
Daniel P Hashim, Narayanan T Narayanan, Jose M Romo-Herrera, David A Cullen, Myung Gwan Hahm, Peter Lezzi, Joseph R Suttle, Doug Kelkhoff, E Muñoz-Sandoval, Sabyasachi Ganguli, Ajit K Roy, David J Smith, Robert Vajtai, Bobby G Sumpter, Vincent Meunier, Humberto Terrones, Mauricio Terrones, Pulickel M Ajayan
The establishment of covalent junctions between carbon nanotubes (CNTs) and the modification of their straight tubular morphology are two strategies needed to successfully synthesize nanotube-based three-dimensional (3D) frameworks exhibiting superior material properties. Engineering such 3D structures in scalable synthetic processes still remains a challenge. This work pioneers the bulk synthesis of 3D macroscale nanotube elastic solids directly via a boron-doping strategy during chemical vapour deposition, which influences the formation of atomic-scale "elbow" junctions and nanotube covalent interconnections...
2012: Scientific Reports
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