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https://www.readbyqxmd.com/read/28938463/role-of-cyp51-in-the-regulation-of-t3-and-fsh-induced-steroidogenesis-in-female-mice
#1
Juan Liu, Ye Tian, Yu Ding, Dai Heng, Kaili Xu, Wenbo Liu, Cheng Zhang
Cytochrome P450 lanosterol 14α-demethylase (CYP51) is a key enzyme in sterols and steroids biosynthesis that involved in folliculogenesis and oocyte maturation, which is regulated by follicle stimulating hormone (FSH), as a key reproductive hormone during follicular development. Thyroid hormone (TH) is also important for normal reproductive function. Although T3 enhances FSH-induced preantral follicle growth, whether and how TH combines with FSH to regulate CYP51 expression during preantral to early antral transition stage is unclear...
August 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28924180/%C3%AE-snap-is-expressed-in-mouse-ovarian-granulosa-cells-and-plays-a-key-role-in-folliculogenesis-and-female-fertility
#2
Alexis Arcos, Matilde de Paola, Diego Gianetti, Diego Acuña, Zahady D Velásquez, María Paz Miró, Gabriela Toro, Bryan Hinrichsen, Rosa Iris Muñoz, Yimo Lin, Gonzalo A Mardones, Pamela Ehrenfeld, Francisco J Rivera, Marcela A Michaut, Luis Federico Batiz
The balance between ovarian folliculogenesis and follicular atresia is critical for female fertility and is strictly regulated by a complex network of neuroendocrine and intra-ovarian signals. Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of multifunctional proteins able to simultaneously coordinate/modulate several cellular pathways is unclear. Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (α-SNAP) is a multifunctional protein that participates in SNARE-mediated membrane fusion events...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903889/gdf9-and-bmp15-expressions-and-fine-structure-changes-during-folliculogenesis-in-polycystic-ovary-syndrome
#3
Meryem İlkay Karagül, Savaş Aktaş, Banu Coşkun Yılmaz, Mustafa Yılmaz, Gülhan Örekiçi Temel
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is the most frequently seen endocrine disorder in women of the reproductive age with the prevalence of about 10%. AIMS: To investigate the efficiency of the growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) during folliculogenesis in a dehydroepiandrosterone (DHEA)-induced mouse PCOS model. STUDY DESIGN: Animal experimentation. METHODS: Mice were divided into three groups; control, vehicle and PCOS group...
September 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28888606/preovulatory-follicle-characteristics-and-oocyte-competence-in-repeat-breeder-dairy-cows
#4
P Sood, M Zachut, I Dekel, H Dube, S Jacoby, U Moallem
The varied and elusive etiology of repeat breeding (RB) in dairy cows necessitates evaluation of oocytes and follicles, which have not previously been assessed together. Accordingly, we evaluated characteristics of preovulatory follicles and the competence of oocytes in control (CTL) and RB cows. The estrous cycles of 35 cows (18 CTL and 17 RB) were synchronized using PGF2α and estrus detection. Cows with a corpus luteum were treated with PGF2α and, 14 to 15 d after a visible behavioral estrus, they were administered a second PGF2α, followed 48 h later by follicular fluid (FF) aspiration of the preovulatory follicles...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28884412/mesenchymal-stem-cells-mscs-therapy-for-recovery-of-fertility-a-systematic-review
#5
REVIEW
Zahra Fazeli, Atieh Abedindo, Mir Davood Omrani, Sayyed Mohammad Hossein Ghaderian
In recent years, the mesenchymal stem cells (MSCs) have provided the new opportunities to treat different disorders including infertility. Different studies have suggested that the MSCs have ability to differentiate into germ-like cells under specific induction conditions as well as transplantation to gonadal tissues. The aim of this systematic review was to evaluate the results obtained from different studies on MSCs therapy for promoting fertility. This search was done in PubMed and Science Direct databases using key words MSCs, infertility, therapy, germ cell, azoospermia, ovarian failure and mesenchymal stem cell...
September 7, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28867214/lithium-chloride-inhibits-star-and-progesterone-production-through-gsk-3%C3%AE-and-erk1-2-signaling-pathways-in-human-granulosa-lutein-cells
#6
Long Bai, Hsun-Ming Chang, Jung-Chien Cheng, Guiyan Chu, Peter C K Leung, Gongshe Yang
Lithium chloride (LiCl) is a widely-used medication to treat neurological disorders that has undesirable side effects on the female reproductive system. It has been show that LiCl can inhibit ovarian folliculogenesis, promote follicle atresia and suppress steroid hormone production in rodents. However, the effects of LiCl on human ovarian steroidogenesis remain completely unknown. In this study, both primary and immortalized human granulosa-lutein (hGL) cells were used to investigate the effects of LiCl on progesterone production and its related enzyme expression as well as the underlying mechanisms...
August 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28864983/epigenetic-influences-during-the-periconception-period-and-assisted-reproduction
#7
Akwasi A Amoako, Tamer M Nafee, Bolarinde Ola
The periconception period starts 6 months before conception and lasts until the tenth week of gestation. In this chapter, we will focus on epigenetic modifications to DNA and gene expression within this period and during assisted reproduction. There are two critical times during the periconception window when significant epigenetic 'reprogramming' occur: one during gametogenesis and another during the pre-implantation embryonic stage. Furthermore, assisted conception treatments, laboratory protocols and culture media can affect the embryo development and birth weights in laboratory animals...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28860512/regulation-of-androgen-receptor-signaling-by-ubiquitination-during-folliculogenesis-and-its-possible-dysregulation-in-polycystic-ovarian-syndrome
#8
Jung Jin Lim, Patricia D A Lima, Reza Salehi, Dong Ryul Lee, Benjamin K Tsang
Although chronic hyperandrogenism suppresses antral follicular development, a phenomenon often observed in polycystic ovarian syndrome (PCOS), whether and how deregulation of androgen receptor (AR) signaling is involved, is not well understood. In the present study, we examined the role of ring finger protein 6 (RNF6) in AR ubiquitination and the possible dysregulation in the expression and actions of growth differentiation factor 9 (GDF9) and kit-ligand (Kitlg) in a chronic androgenized PCOS rat model. 5α-dihydrotestosterone (DHT) treatment in vivo inhibited antral follicle growth, a response mediated through increased RNF6 content, suppressed K63- but increased K48-linked AR ubiquitination as well as the mRNA expression and content of soluble KIT-L (sKitlg) and content of GDF9...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28849206/maternal-diabetes-impairs-the-initiation-of-meiosis-in-murine-female-germ-cells
#9
Xu-Hua Qiu, Mei-Ling Li, Ng Li, Qin Sun, Ji Zhou, Ru-Jun Ma, Ying Lin, Min Xie, Xie Ge, Li Chen, Bing Yao
Gestational diabetes mellitus (GDM) is characterized by an initial diagnosis of glucose intolerance during pregnancy. There is increasing evidence supporting the association between GDM and the inhibited development of several organs in offspring. In the present study, a murine GDM model was established in mice by intraperitoneal injection of streptozotocin to evaluate the effect of maternal diabetes on the initiation of meiosis in female germ cells of offspring. The effect of GDM on the initiation of meiosis in the offspring was evaluated by reverse transcription-quantitative polymerase chain reaction, flow cytometry and hematoxylin and eosin staining...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28845753/follistatin-rescues-blastocyst-development-of-poor-quality-porcine-cumulus-oocyte-complexes-by-delaying-meiotic-resumption-with-decreased-cgmp
#10
Bo Myeong Lee, Ju Lan Chun, Ji Hye Lee, Eun Young Kim, Kang-Sun Park, Jin-Hee Lee, Bradford W Daigneault, George W Smith, Keun Jung Kim, Kyu-Tae Chang, Sang-Rae Lee, Sun-Uk Kim, Seon-A Choi, Kyung-Bon Lee, Min Kyu Kim
Mammalian oocytes resume maturation when removed from follicles and cultured in vitro. During folliculogenesis, oocytes are bathed in follicular fluid (FF), which provides an important and specialized microenvironment for oocyte competence. Follistatin (FST) is one component of FF that may play a role in oocyte maturation and embryo development. This study was conducted to examine possible effects of FST on porcine oocyte competence and embryo development. Exogenous FST in oocyte maturation medium for 22 or 44 hours did not improve nuclear maturation and had no effect on good quality cumulus-oocyte complexes (COCs)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28841535/female-reproductive-traits-of-a-commercially-exploited-skate-atlantoraja-platana-g%C3%A3-nther-1880-chondrichthyes-rajidae-ovarian-morphology-gametogenesis-and-microscopic-verification-of-maturity-criteria
#11
A C Moya, A Wehitt, M C Díaz Andrade, E E Di Giacomo, E J Galíndez
Atlantoraja platana is an endemic species of the Southwest Atlantic Ocean, and is one of the most captured by the local bottom trawl industrial fisheries. In this work, the microscopic architecture of mature female's gonads and the dynamics of follicle development are studied as a contribution to raise awareness of reproductive biology of the species. Folliculogenesis depicts the same histologic pattern as in other Elasmobranchs. Follicles in different degrees of maturation coexist in mature animals. The oogonia were only found in immature individuals...
August 12, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28837789/repertoire-of-bone-morphogenetic-proteins-and-growth-differentiation-factors-in-ovary-of-the-indian-wall-lizard-hemidactylus-flaviviridis-with-emphasis-on-differential-expression-and-gonadotropic-regulation-of-bmp15-and-gdf9
#12
Mamta Tripathy, Manisha Priyam, Umesh Rai
Analysis of ovarian transcriptome of Indian wall lizard demonstrates the existence of several bone morphogenetic proteins (bmp1, 2, 3, 3b, 7, 8, 15) and growth/differentiation factors (gdf5, 9) for the first time in reptilian ovary. The characterization of putative full-length/partial protein sequences of BMPs (BMP2, 3, 3b, 7, 15) and GDF9 showed high homology of their TGF-β domain with that of other vertebrates while BMP1 bore homology to zinc-dependent metalloprotease. Phylogenetic analyses showed clustering of BMPs and GDF9 from wall lizards with that of squamates lying in close proximity to chelonia, crocodilia and aves...
August 21, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28836396/morphological-and-molecular-aspects-of-in-vitro-culture-of-preantral-follicles-derived-from-vitrified-ovarian
#13
Mahboobeh Amoushahi, Mojdeh Salehnia, Seyed Javad Mowla, Nassim Ghorbanmehr
OBJECTIVE: This study aimed to evaluate the expression of the genes related to folliculogenesis after vitrification of mouse ovarian tissues using a two-step in vitro culture. MATERIALS AND METHODS: In this experimental study, vitrified and non-vitrified ovaries from 7- day old (neonate) female mice were cultured using alpha-Minimum Essential Medium (α-MEM) supplemented with 5% fetal bovine serum (FBS) for 7 days. Morphology, surface area of ovaries and percentage of normal follicles were evaluated and compared in both groups...
October 2017: Cell Journal
https://www.readbyqxmd.com/read/28827819/the-effects-of-dexamethasone-administered-during-pregnancy-on-the-postpartum-spiny-mouse-ovary
#14
Monika Hułas-Stasiak, Piotr Dobrowolski, Bożena Pawlikowska-Pawlęga, Ewa Tomaszewska, Siemowit Muszyński
Excessive exposure to glucocorticoids can alter ovarian function by modulating oogenesis, folliculogenesis and steroidogenesis. The aim of the present study was to examine the effects of dexamethasone (DEX) administered during pregnancy on folliculogenesis and corpus luteum development in the postpartum spiny mouse ovary. DEX (125 μg kg-1 body weight per day) was applied to pregnant spiny mouse from day 20 of gestation to parturition. The obtained ovaries were fixed and used for immunohistochemistry and TEM analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28826600/fmr1-and-akt-mtor-signalling-pathways-potential-functional-interactions-controlling-folliculogenesis-in-human-granulosa-cells
#15
Julia Rehnitz, Diego D Alcoba, Ilma S Brum, Katrin Hinderhofer, Berthe Youness, Thomas Strowitzki, Peter H Vogt
Granulosa cells (GCs) play a major role in folliculogenesis and are crucial for oocyte maturation and growth. In these cells, the mTOR/AKT signalling pathway regulates early folliculogenesis by maintaining the dormancy of primordial follicles, while FSH induces their further differentiation and maturation. Because changes in number of CGG triplets in FMR1 exon 1 (below or beyond normal values of 26-34 triplets) affect ovarian reserve and pre-mutations containing >54 CGG triplets represent a known risk factor for premature ovarian insufficiency/failure, we investigated in the human GC model (COV434) how FMR1/FMRP and mTOR/AKT are expressed and potentially interact during GC proliferation...
August 4, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28822776/assessment-of-ovarian-follicular-dynamics-and-folliculogenesis-associated-endocrine-profiles-following-gonadotropin-stimulation-in-the-bonnet-monkey
#16
Bhupathi Sukesh, Muraly Puttabyatappa, Augustine T Peter, Rudraiah Medhamurthy, Polani B Seshagiri
We evaluated ovarian follicular dynamics in bonnet monkeys by employing trans-abdominal ultrasonography. Following the administration of human follicle stimulating hormone (hFSH) and/or human menopausal gonadotropin (hMG), multiple follicular development was assessed and their numbers, size and growth profiles were monitored. The ultrasonograms showed that the follicular antrum appeared distinctly anechoic with well-defined hyperechoic borders. Depending on the type, quantity (12.5-25IU), and duration (6-9days) of hormones administered, the number of developing follicles was 2-12 per ovary with their lowest diameter being 2mm...
August 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28804932/kisspeptin-regulates-ovarian-steroidogenesis-during-delayed-embryonic-development-in-the-fruit-bat-cynopterus-sphinx
#17
Anuradha, Amitabh Krishna
Cynopterus sphinx, a fruit bat, undergoes delayed embryonic development during the winter months, a period that corresponds to low levels of progesterone and estradiol synthesis by the ovary. Kisspeptins (KPs) are a group of neuropeptide hormones that act via G-protein coupled receptor 54 (GPR54) to stimulate hypothalamic secretion of Gonadotropin-releasing hormone, thereby regulating ovarian steroidogenesis, folliculogenesis, and ovulation. GPR54 is also expressed in the ovary, suggesting a direct role for KPs in ovarian steroidogenesis...
August 14, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28803863/epidermal-e-cadherin-dependent-%C3%AE-catenin-pathway-is-phytochemical-inducible-and-accelerates-anagen-hair-cycling
#18
Noha S Ahmed, Subhadip Ghatak, Mohamed S El Masry, Surya C Gnyawali, Sashwati Roy, Mohamed Amer, Helen Everts, Chandan K Sen, Savita Khanna
Unlike the epidermis, which regenerates continually, hair follicles anchored in the subcutis periodically regenerate by spontaneous repetitive cycles of growth (anagen), degeneration (catagen), and rest (telogen). The loss of hair follicles in response to injuries or pathologies such as alopecia endangers certain inherent functions of the skin. Thus, it is of interest to understand mechanisms underlying follicular regeneration in adults. In this work, a phytochemical rich in the natural vitamin E tocotrienol (TRF) served as a productive tool to unveil a novel epidermal pathway of hair follicular regeneration...
July 20, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28801854/how-do-red-and-infrared-low-level-lasers-affect-folliculogenesis-cycle-in-rat-s-ovary-tissue-in-comparison-with-clomiphene-under-in-vivo-condition
#19
Paria Naseri, Alireza Alihemmati, Seyed Hossein Rasta
Folliculogenesis is a cycle that produces the majority of oocyte. Any disruption to this cycle leads to ovulation diseases, like polycystic ovarian syndrome (PCOS). Treatments include drugs and surgery; lasers have also been used complementarily. Meanwhile, still there is no definite treatment for PCOS. This study investigated the photo-bio stimulation effect of near-infrared and red low-level laser on producing follicles and compared the result with result of using common drug, clomiphene. Therefore, the aim of this study was to propose the use of lasers autonomously treatment...
August 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28799235/dipeptidyl-peptidase-4-serum-activity-and-concentration-are-increased-in-women-with-polycystic-ovary-syndrome
#20
Sindy Blauschmidt, Thomas Greither, Katharina Lampe, Solveig Köller, Petra Kaltwaßer, Hermann M Behre
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a complex disease, the aetiology of which is not well understood. Alterations in potential candidate genes involved in the biosynthesis and metabolism of androgens, folliculogenesis and insulin and glucose metabolism have been suggested as possible aetiologies. Dipeptidyl peptidase-4 (DPP4) plays a key role in glucose homoeostasis and, thus, in the regulation of insulin secretion. The aim of our study was to analyse the DPP4 activity and concentrations in the serum of PCOS and non-PCOS patients and, additionally, study the activation of the DPP4 promoter by androgens in vitro...
August 11, 2017: Clinical Endocrinology
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