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A Case Report of Malignant Perivascular Epithelioid Cell Tumors of the Uterus and Literature Review.
Daifeng Hu, Mengyue Miao, Hui Zhou, Xia Gu, Xuedan Wang, Alexander Tobias Teichmann, Qin Wang, Youzhe Yang
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors originating from perivascular epithelioid cells. In gynecological system, the uterus is one of the most common sites affected by PEComas. Most PEComas are benign, and patients usually have a good prognosis. However, malignant uterus PEComa is rare, and better comprehensive epidemiological investigations are needed. To date, there are a few reported cases of uterus PEComa. We herein report a rare case of malignant PEComa occurred in the uterine corpus and cervix, possibly accompanied by pulmonary lymphangioleiomyomatosis (PLAM)...
2024: International Journal of Women's Health
#2
Jared Morse, Danna Wang, Serena Mei, Danielle Whitham, Colby Hladun, Costel C Darie, Herman O Sintim, Modi Wang, KaHo Leung
UNLABELLED: The cGAS-STING signaling pathway has emerged as a key mediator of inflammation. However, the roles of chloride homeostasis on this pathway are unclear. Here, we uncovered a correlation between chloride homeostasis and cGAS-STING signaling. We found that dysregulation of chloride homeostasis attenuates cGAS-STING signaling in a lysosome-independent manner. Treating immune cells with chloride channel inhibitors attenuated 2'3'-cGAMP production by cGAS and also suppressed STING polymerization, leading to reduced cytokine production...
April 9, 2024: bioRxiv
#3
Benjamin Suarez-Jimenez, Claire Marino, Pavel Rjabtsenkov, Caitlin Sharp, Zonia Ali, Evelyn Pineda, Shreya Bavdekar, Tanya Garg, Kendal Jordan, Mary Halvorsen, Carlos Aponte, Julie Blue, Xi Zhu
Using spatial mapping processes to learn about threat and safety in an environment is crucial for survival. Research using conditioning paradigms has explored the effects of state (transient arousal) and trait anxiety (anxiety as an aspect of personality) on threat learning and acquisition. However, results are mixed, and little is known regarding why some individuals do not learn to discriminate between threat and safety during contextual conditioning. We used a virtual reality (VR) contextual threat conditioning paradigm to elucidate the effects of state and trait anxiety on contextual threat learning...
April 3, 2024: Research Square
#4
JOURNAL ARTICLE
Melissa Brooks Peterson, Justin L Lockman, Myron Yaster
No abstract text is available yet for this article.
April 21, 2024: Paediatric Anaesthesia
#5
JOURNAL ARTICLE
Grant M Fabrizio, Casey Cardillo, Alexander Egol, Joshua C Rozell, Ran Schwarzkopf, Vinay K Aggarwal
INTRODUCTION: The importance of identifying how patients choose their healthcare providers has grown with the prevalence of consumer-centric health insurance plans. There is currently a lack of studies exploring the factors associated with how patients select their hip and knee joint arthroplasty surgeons. The purpose of this study was to determine how patients find their arthroplasty providers and the relative importance of various arthroplasty surgeon characteristics. METHODS: An electronic mail survey was sent to 3522 patients who had visited our institution for an arthroplasty surgeon office visit between August 2022 and January 2023...
April 19, 2024: Archives of Orthopaedic and Trauma Surgery
#6
JOURNAL ARTICLE
G M Baldini, A S Laganà, A Mastrorocco, A Malvasi, D Baldini, D Ferri, R Sciorio, G Trojano
OBJECTIVE: The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval for patients with endometrioma that makes ovum pick-up hard due to poor ovarian surgical accessibility. PATIENTS AND METHODS: Cases of 251 women with ovarian endometriomas undergoing in vitro fertilization (IVF) in our infertility unit were retrospectively analyzed to evaluate the clinical IVF cycle outcomes after oocyte retrieval. Controls (n = 251) were age-matched women without endometriomas who underwent an uncomplicated oocyte retrieval...
April 2024: European Review for Medical and Pharmacological Sciences
#7
JOURNAL ARTICLE
Enrico Casadei, Enrico Valli, Alessandra Bendini, Sara Barbieri, Rosalba Tucci, Federico Ferioli, Tullia Gallina Toschi
A "green breakthough" at the table due to consumer demand for healthy and sustainable foods, which aligns with the typical Mediterranean diet, has recently led to an increase in the consumption of products such as extra virgin olive oil. In fact, Italian olive cultivation, which contributes an average of 15% of world production, has seen the production of extra virgin olive oil with a value of exports that have doubled in the last 20 years. In this context, the olive oil sector of the Emilia-Romagna region (Italy), and in particular the PDO Brisighella, could achieve greater success with consumers by proposing a product obtained through sustainable agriculture that enhances the content of bioactive compounds...
2024: Frontiers in Nutrition
#8
JOURNAL ARTICLE
Ludovico Muzii, Giulia Galati, Ilenia La Barbiera, Antonella Linari, Oriana Capri, Daniela Pietrangeli, Edgardo Somigliana
PURPOSE: Failure to collect oocytes at the time of oocyte pick-up is an unfavorable outcome of in vitro fertilization (IVF) cycles. In these cases, prompt intrauterine insemination (IUI) could be an option (rescue IUI), but this possibility has been poorly studied. METHODS: Rescue IUI is routinely offered in our unit in women failing to retrieve oocytes, provided that they have at least one patent tube, normal male semen analysis, and the total number of developed follicles is ≤ 3...
April 18, 2024: Journal of Assisted Reproduction and Genetics
#9
JOURNAL ARTICLE
Chloé R Nater
Research Highlight: Christian, M., Oosthuizen, W. C., Bester, M. N., & de Bruyn, P. N. (2024). Robustly estimating the demographic contribution of immigration: Simulation, sensitivity analysis and seals. Journal of Animal Ecology. https://doi.org/10.1111/1365-2656.14053. Immigration can have profound consequences for local population dynamics and demography, but collecting data to accurately quantifying it is challenging. The recent rise of integrated population models (IPMs) offers an alternative by making it possible to estimate immigration without the need for explicit data, and to quantify its contribution to population dynamics through transient Life Table Response Experiments (tLTREs)...
April 17, 2024: Journal of Animal Ecology
#10
JOURNAL ARTICLE
Han Zhou
Traditional apple-picking robots are unable to detect apples in real-time in complex environments. In order to improve detection efficiency, a fast CenterNet apple recognition method for multiple apple targets in dense scenes is proposed. This method can quickly and accurately identify multiple apple targets in dense scenes. The backbone network mainly consists of resnet-44 fully convolutional network, region of interest network (RPN), and region of interest (ROI). The experimental results show that the improved YoloV5 network model has a higher recognition accuracy of 94...
April 15, 2024: Heliyon
#11
JOURNAL ARTICLE
Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nicole Tamvaka, Ronald L Walton, Matthew C Baker, Hannah L Macpherson, Raquel Real, Alexandra I Soto-Beasley, Kin Mok, Tamas Revesz, Elizabeth A Christopher, Michael DeTure, William W Seeley, Edward B Lee, Matthew P Frosch, Laura Molina-Porcel, Tamar Gefen, Javier Redding-Ochoa, Bernardino Ghetti, Andrew C Robinson, Christopher Kobylecki, James B Rowe, Thomas G Beach, Andrew F Teich, Julia L Keith, Istvan Bodi, Glenda M Halliday, Marla Gearing, Thomas Arzberger, Christopher M Morris, Charles L White, Naguib Mechawar, Susana Boluda, Ian R MacKenzie, Catriona McLean, Matthew D Cykowski, Shih-Hsiu J Wang, Caroline Graff, Rashed M Nagra, Gabor G Kovacs, Giorgio Giaccone, Manuela Neumann, Lee-Cyn Ang, Agostinho Carvalho, Huw R Morris, Rosa Rademakers, John A Hardy, Dennis W Dickson, Jonathan D Rohrer, Owen A Ross
BACKGROUND: Pick's disease is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary tauopathy. Pick's disease is pathologically defined by the presence in the frontal and temporal lobes of Pick bodies, composed of hyperphosphorylated, three-repeat tau protein, encoded by the MAPT gene. MAPT has two distinct haplotypes, H1 and H2; the MAPT H1 haplotype is the major genetic risk factor for four-repeat tauopathies (eg, progressive supranuclear palsy and corticobasal degeneration), and the MAPT H2 haplotype is protective for these disorders...
May 2024: Lancet Neurology
#12
JOURNAL ARTICLE
Gaël Nicolas
No abstract text is available yet for this article.
May 2024: Lancet Neurology
#13
JOURNAL ARTICLE
Lisa M Pick, Viviane Oehme, Julia Hartmann, Jessica Wenzlaff, Qingyun Tang, Gideon Grogan, Marion B Ansorge-Schumacher
Silyl ethers fulfil a fundamental role in synthetic organic chemistry as protecting groups and their selective cleavage is an important factor in their application. We present here for the first time two enzymes, SilE-R and SilE-S, which are able to hydrolyze silyl ethers. They belong to the stress-response A/B barrel domain (DABB) family and are able to cleave the Si-O bond with opposite enantiopreference. Silyl ethers containing aromatic, cyclic or aliphatic alcohols and, depending on the alcohol moiety, silyl functions as large as TBDMS are accepted...
April 17, 2024: Angewandte Chemie
#14
JOURNAL ARTICLE
Yixiao Ding, Lin Du, Han Hao, Thomas C E Mier, Jan Van der Spiegel, Timothy H Lucas, Firooz Aflatouni, Andrew G Richardson, Mark G Allen
This paper reports a microfabricated triaxial capacitive force sensor. The sensor is fully encapsulated with inert and biocompatible glass (fused silica) material. The sensor comprises two glass plates, on which four capacitors are located. The sensor is intended for subdermal implantation in fingertips and palms and providing tactile sensing capabilities for patients with paralyzed hands. Additional electronic components, such as passives and IC chips, can also be integrated with the sensor in a hermetic glass package to achieve an implantable tactile sensing system...
January 2024: Proceedings—IEEE International Conference on Micro Electro Mechanical Systems
#15
JOURNAL ARTICLE
Jintana Wiboonsirikul, Pornthipa Ongkunaruk, Piyarat Poonpan
The production of coconut sap beverages faces a challenge with the quality of the incoming coconut sap sourced from farmers. The clarification of pivotal factors influencing the quality of coconut sap after harvesting is of paramount importance for fostering mutual benefit between the involved parties. This research focuses on assessing the quality and degradation of coconut sap during the post-harvest stage. It addresses the shortcomings in evaluating coconut sap quality and improper pick-up conditions. To improve these processes, various experiments were designed, including 1) preliminary experiments that explored microbial count, pH, and soluble solids in harvested coconut sap at varying intervals, and 2) the L9 Taguchi Orthogonal Array method...
April 30, 2024: Heliyon
#16
JOURNAL ARTICLE
Masaru Kato, Shinichi Maruyama, Noriko Watanabe, Risa Yamada, Yuki Suzaki, Masaru Ishida, Hiroshi Kanno
Pazopanib is a multi-kinase inhibitor used to treat advanced/metastatic renal cell carcinoma and advanced soft tissue tumors; however, side effects such as diarrhea and hypertension have been reported, and dosage adjustment based on drug concentration in the blood is necessary. However, measuring pazopanib concentrations in blood using the existing methods is time-consuming; and current dosage adjustments are made using the results of blood samples taken at the patient's previous hospital visit (approximately a month prior)...
April 15, 2024: AAPS Journal
#17
JOURNAL ARTICLE
Anders Helander, Malin Johansson, Tomas Villén, Annika Andersson
This study investigated the effects of hexahydrocannabinol (HHC) and other unclassified cannabinoids, which were recently introduced to the recreational drug market, on cannabis drug testing in urine and oral fluid samples. After the appearance of HHC in Sweden in 2022, the number of posts about HHC on an online drug discussion forum increased significantly in the spring of 2023, indicating increased interest and use. In parallel, the frequency of false positive screening tests for tetrahydrocannabinol (THC) in oral fluid, and for its carboxy metabolite (THC-COOH) in urine, rose from <2% to >10%...
April 15, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
#18
JOURNAL ARTICLE
Fatemeh Alipouran, Ehsan Ghayoor Karimiani, Jina Khayatzadeh
BACKGROUND: Congenital liver disease refers to a group of heterogeneous diseases from a clinical genetic point of view. The most crucial features are hepatosplenomegaly and elevated liver enzymes. This study aims to identify genetic variants causing the disease in three Iranian families with congenital liver disease using molecular techniques. METHODS: Patients were referred to Next Generation Genetic Polyclinic (NGGC) in Mashhad after confirmed congenital liver disease diagnosis by gastroenterologists...
October 2023: Reports of Biochemistry & Molecular Biology
#19
Jianbin Su, Xianjin Xu, Leland J Cseke, Sean Whittier, Ruimei Zhou, Zhengzhi Zhang, Zackary Dietz, Kamal Singh, Bing Yang, Shi-You Chen, William Picking, Xiaoqin Zou, Walter Gassmann
Formation of biomolecular condensates can be driven by weak multivalent interactions and emergent polymerization. However, the mechanism of polymerization-mediated condensate formation is less studied. We found lateral root cap cell (LRC)-specific SUPPRESSOR OF RPS4-RLD1 (SRFR1) condensates fine-tune primary root development. Polymerization of the SRFR1 N-terminal domain is required for both LRC condensate formation and optimal root growth. Surprisingly, the first intrinsically disordered region (IDR1) of SRFR1 can be functionally substituted by a specific group of intrinsically disordered proteins known as dehydrins...
April 3, 2024: bioRxiv
#20
JOURNAL ARTICLE
Qin Xiong, Xueying Wang, Jinwen Li, Xiaoying Zhai, Tengjiao Ma, Siyi Ni, Linkai Cui
In June 2023, severe leaf spots were noted in Populus × euramericana cv 'Nanlin95' plantations located in the Nanjing Baguazhou Wetland Park (32°09'16.97″N, 118°48'16.74″E) of Jiangsu Province and Populus × canadensis cv 'Sacrau 79' and Populus × canadensis cv 'Guariento' in the Liyuan Village in Nanyang City (32°53'43.70″N, 112°17'29.12″E) of Henan Province, respectively. The disease incidence in both locations could reach 97.9% (556 out of 568 trees) and 98...
April 14, 2024: Plant Disease
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