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https://www.readbyqxmd.com/read/29334609/score-for-the-survival-probability-in-metastasis-breast-cancer-a-nomogram-based-risk-assessment-model
#1
Zhenchong Xiong, Guangzheng Deng, Xinjian Huang, Xing Li, Xinhua Xie, Jin Wang, Zeyu Shuang, Xi Wang
Purpose: Survival of metastatic breast cancer patient remains unknown and varies greatly from person to person. Thus, we aimed to construct a nomogram to quantify the survival probability of patients with metastatic breast cancer (MBC). Materials and methods: We had included 793 MBC patients and calculated trends of case fatality rate by Kaplan-Meier method and joinpoint regression. 634 patients with MBC between January 2004 and July 2011 and 159 patients with MBC between August 2011 and July 2013 were assigned to training cohort and internal validation cohort, respectively...
January 2, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334554/the-systemic-immune-inflammation-index-independently-predicts-survival-and-recurrence-in-resectable-pancreatic-cancer-and-its-prognostic-value-depends-on-bilirubin-levels-a-retrospective-multicenter-cohort-study
#2
Mohammad Hosein Aziz, Kostandinos Sideras, Nasir Ahmad Aziz, Katya Mauff, Roel Haen, Daphne Roos, Lawlaw Saida, Mustafa Suker, Erwin van der Harst, Jan Sven Mieog, Bert A Bonsing, Yarne Klaver, Bas Groot Koerkamp, Casper H van Eijck
OBJECTIVE: Our aim was to determine the prognostic significance of the systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as the primary outcome. BACKGROUND: Pancreatic cancer is associated with a dysfunctional immune system and poor prognosis. We examined the prognostic significance of the SIII in patients with resectable pancreatic ductal adenocarcinoma (PDAC) and the effects of bilirubin on this index...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29334300/the-impact-of-early-molecular-response-in-children-and-adolescents-with-chronic-myeloid-leukemia-treated-with-imatinib-a-single-center-study-from-china
#3
Haigang Shao, Zhao Zeng, Jiannong Cen, Jun Zhang, Shuxiao Bai, Chunxiao Wu, Yanlei Gong, Yong Wang, Huiying Qiu, Suning Chen, Jinlan Pan
Chronic myeloid leukemia (CML) is rare among children and adolescents. The early molecular response (EMR) is an important prognostic significance for adult CML patients. This study explored the impact of EMR on the prognosis in 40 children and adolescents with CML-CP treated with imatinib (IM). Our results showed that a high proportion of patients failed to achieve the BCR-ABL1/ABL1 International Scale (IS) ≤ 10% at 3 months. Children with a BCR-ABL1/ABL1 ≤ 10% at 3 months and <1% at 6 months increased the rate of achieving complete cytogenetic response (CCyR) and/or major molecular response (MMR) at 12 months compared to those with BCR-ABL1/ABL1 > 10%...
January 15, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29333782/-research-advances-on-the-molecular-mechanism-of-autophagy-regulated-by-porphyromonas-gingivalis
#4
Zhao Yan, Yu Yang, Kou Yurong
Autophagy is an intracellular conservative degradation pathway. This event has been considered as a key step in host defense against bacterial infection. However, Porphyromonas gingivalis, as one of the evidence-sufficient periodontal pathogens, can utilize self-induced autophagy to achieve persistent intracellular survival and proliferation, which enable this organism to escape from host immune surveillance. This review focuses on molecular mechanism of P. gingivalis internalization and autophagy to illuminate its pathogenesis and to further explore the relationship between P...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29333404/relevance-of-prognostic-index-with-%C3%AE-2-microglobulin-for-patients-with-diffuse-large-b-cell-lymphoma-in-the-rituximab-era
#5
Jihoon Kang, Shinkyo Yoon, Cheolwon Suh
Background: The International Prognostic Index (IPI) has been a useful tool for predicting the prognosis of aggressive non-Hodgkin lymphoma in the last 20 years. Herein, we aimed to develop a new prognostic model for diffuse large B-cell lymphoma (DLBCL) in the rituximab era. Methods: Between March 2004 and June 2012, patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy regimen were identified in the database of the Asan Medical Center (AMC) Lymphoma Registry...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29333403/treatment-outcomes-of-dose-attenuated-chop-chemotherapy-in-elderly-patients-with-peripheral-t-cell-lymphoma
#6
Eun-Ji Choi, Jung Yong Hong, Dok Hyun Yoon, Jihoon Kang, Chan-Sik Park, Jooryung Huh, Eun Jin Chae, Yoonse Lee, Jin-Sook Ryu, Cheolwon Suh
Background: While cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is the most commonly used chemotherapeutic regimen for patients with peripheral T-cell lymphomas (PTCLs), elderly patients are more vulnerable to associated toxicities. We evaluated the efficacy and safety of dose-attenuated CHOP in elderly patients with PTCL. Methods: Patients with PTCL aged >70 years or 65-70-years with comorbidities were treated with dose-attenuated CHOP (cyclophosphamide: 562...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29333016/clinicopathological-features-and-outcomes-in-primary-central-nervous-system-lymphoma-a-10-year-experience
#7
Chaitanya Krishna Puligundla, Stalin Bala, Ashok Kumar Karnam, Sadashivudu Gundeti, Tara Roshni Paul, Megha S Uppin, Lakshmi Srinivas Maddali
Context: Primary central nervous system lymphoma (PCNSL) is a variant of extranodal lymphoma, accounting for 4% of primary central nervous system tumors. PCNSL was more common in immunocompetent individuals. International Extranodal Lymphoma Study Group (IELSG) scoring was used for prognostication. High-dose methotrexate regimens along with radiotherapy improved outcomes in PCNSL. Aims: The aim of this study is to analyze the clinical and pathological features, progression-free survival (PFS), and overall survival (OS) in patients with PCNSL...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332327/stage-ii-thymoma-and-emergency-coronary-artery-bypass-to-irradiate-or-not-to-irradiate-to-avoid-radiation-induced-vascular-injury-case-report-and-literature-review
#8
Ilias A Kouerinis, Maria Tolia, Flora Zagouri, Michail Nikolaou, Nikolaos Tsoukalas, George Kyrgias, Meletios A Dimopoulos, Charalambos Vlachopoulos, Ioannis Karathanassis, Christina K Zoubouli, Ioannis Kokakis, Vasileios Kouloulias, Konstantinos Triantafillou
PURPOSE: The purpose of this study was to present the controversial role of adjuvant radiotherapy to a 72-year-old male patient with Masaoka stage II thymoma and coronary artery bypass and to review the relevant literature. METHODS: The data were collected by relevant studies on PubMed and EMBASE. Articles up to March 2017 were included. RESULTS: Although the radiation-induced vascular injury to the internal thoracic artery and its suitability for grafting in a patient who is candidate for coronary artery bypass is documented, the possible catastrophic effect of adjuvant radiotherapy to existing grafts in a patient with prior bypass surgery has not been fully investigated...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331996/relevance-of-enlarged-cardiophrenic-lymph-nodes-in-determining-prognosis-of-patients-with-advanced-ovarian-cancer
#9
Hasan Shahriar Md Nuruzzaman, Grace Hwei Ching Tan, Ravichandran Nadarajah, Melissa Teo
Ovarian cancer often presents at an advanced stage with widespread peritoneal and/or extra-abdominal metastases. Complete cytoreduction is the mainstay of treatment for disease confined to peritoneum. But in patients with distant metastases, the role and rationale is less obvious. One of the the most common sites of extra-abdominal disease is the cardiophrenic lymph node (CPLN). In this paper, we described the management of a patient with International Federation of Gynecology and Obstetrics (FIGO) stage IVB epithelial ovarian carcinoma and widespread peritoneal and extra-abdominal metastases to the CPLN, who underwent complete cytoreduction including excision of enlarged CPLN, following neoadjuvant chemotherapy...
January 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29331568/overall-survival-and-oncological-outcomes-after-partial-nephrectomy-and-radical-nephrectomy-for-ct2a-renal-tumors-a-collaborative-international-study-from-the-french-kidney-cancer-research-network-uroccr
#10
B Reix, J-C Bernhard, J-J Patard, P Bigot, A Villers, E Suer, N S Vuong, G Verhoest, Q Alimi, J-B Beauval, T Benoit, F-X Nouhaud, C Lenormand, N Hamidi, J Cai, M Eto, S Larre, A El Bakhri, G Ploussard, A Hung, N Koutlidis, A Schneider, J Carrouget, S Droupy, S Marchal, A Doerfler, S Seddik, T Matsugasumi, X Orsoni, A Descazeaud, C Pfister, K Bensalah, M Soulie, I Gill, V Flamand
BACKGROUND: Partial nephrectomy (PN) is recommended as first-line treatment for cT1 stage kidney tumors because of a better renal function and probably a better overall survival than radical nephrectomy (RN). For larger tumors, PN has a controversial position due to lack of evidence showing good cancer control. The aim of this study was to compare the results of PN and RN in cT2a stage on overall survival and oncological results. METHOD: A retrospective international multicenter study was conducted in the frame of the French kidney cancer research network (UroCCR)...
January 10, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29330746/risk-stratified-therapy-for-children-with-flt3-itd-positive-acute-myeloid-leukemia-results-from-the-jplsg-aml-05-study
#11
Akira Shimada, Yuka Iijima-Yamashita, Akio Tawa, Daisuke Tomizawa, Miho Yamada, Shiba Norio, Tomoyuki Watanabe, Takashi Taga, Shotaro Iwamoto, Kiminori Terui, Hiroshi Moritake, Akitoshi Kinoshita, Hiroyuki Takahashi, Hideki Nakayama, Katsuyoshi Koh, Hiroaki Goto, Yoshiyuki Kosaka, Akiko Moriya Saito, Nobutaka Kiyokawa, Keizo Horibe, Yusuke Hara, Kentaro Oki, Yasuhide Hayashi, Shiro Tanaka, Souichi Adachi
Acute myeloid leukemia harboring internal tandem duplication of FMS-like tyrosine kinase 3 (AMLFLT3-ITD) is associated with poor prognosis. We evaluated the results of the AML-05 study, in which all AMLFLT3-ITD patients were assigned to receive hematopoietic stem cell transplantation (HSCT) in the first remission (1CR). We also investigated the effects of additional genetic alterations on FLT3-ITD. The 5-year overall survival (OS) and event-free survival (EFS) rates among the 47 AMLFLT3-ITD patients were 42...
January 12, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29330719/prognostic-value-of-tumor-infiltrating-lymphocyte-density-assessed-using-a-standardized-method-based-on-molecular-subtypes-and-adjuvant-chemotherapy-in-invasive-breast-cancer
#12
Nuri Jang, Hee Jung Kwon, Min Hui Park, Su Hwan Kang, Young Kyung Bae
BACKGROUND: This study investigated the prognostic value of tumor-infiltrating lymphocyte (TIL) density as determined by molecular subtype and receipt of adjuvant chemotherapy in invasive breast cancer (IBC). METHODS: Stromal TIL densities were evaluated in 1489 IBC samples using recommendations proposed by the International TILs Working Group. Cases were allocated to high- and low-TIL density groups using a cutoff of 10%. RESULTS: Of the 1489 IBC patients, 427 (28...
January 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29330279/rare-cause-of-isolated-severe-coagulation-failure-in-cirrhosis-traditional-healing-with-fenugreek
#13
Cyriac A Philips, Philip Augustine
Patients with cirrhosis develop decompensation events during the natural history of the disease that encompass ascites, variceal bleeding, hepatic encephalopathy and jaundice. Coagulation failure, defined using the international normalised ratio, even though not a decompensation event, is important in patients with stratifying cirrhosis into those who require liver transplantation for long-term survival. Isolated coagulation failure in cirrhosis is rare and usually occurs with use of anticoagulants in the setting of vascular diseases...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29330050/production-and-characterization-of-a-novel-site-specific-modifiable-anti-ox40-receptor-single-chain-variable-fragment-for-targeted-drug-delivery
#14
Aki Tanabe, Kazumi Nakano, Makoto Nakakido, Satoru Nagatoishi, Yuetsu Tanaka, Kouhei Tsumoto, Kaoru Uchimaru, Toshiki Watanabe
OX40 receptor (tumor necrosis factor receptor superfamily, member 4; CD134) is a T-cell co-stimulatory molecule that plays an important role in T-cell activation and survival. OX40 receptor is activated by its ligand, OX40L; and modulation of the OX40-OX40L interaction is a promising target for the treatment of autoimmune diseases and cancers. Here, we generated a high-affinity anti-OX40 single-chain variable fragment carrying a C-terminal cysteine residue (scFvC). Physicochemical and functional analyses revealed that the scFvC bound to OX40-expressing cells and was internalized via OX40-mediated endocytosis without inducing phosphorylation of IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), an important complex in the classical NFκB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway...
January 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29329577/respiratory-explants-as-a-model-to-investigate-early-events-of-contagious-bovine-pleuropneumonia-infection
#15
Giovanni Di Teodoro, Giuseppe Marruchella, Andrea Di Provvido, Gianluca Orsini, Gaetano Federico Ronchi, Anna Rita D'Angelo, Nicola D'Alterio, Flavio Sacchini, Massimo Scacchia
Contagious bovine pleuropneumonia (CBPP) is a severe disease caused by Mycoplasma mycoides subsp. mycoides (Mmm). Knowledge on CBPP pathogenesis is fragmented and hampered by the limited availability of laboratory animal and in vitro models of investigation. The purpose of the present study is to assess respiratory explants as useful tools to study the early stages of CBPP. Explants were obtained from trachea, bronchi and lungs of slaughtered cattle, tested negative for Mycoplasma spp. and for the major bacterial and viral respiratory pathogens...
January 12, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29329118/ce-managing-sepsis-and-septic-shock-current-guidelines-and-definitions
#16
Mary Beth Flynn Makic, Elizabeth Bridges
Recent updates emphasize early recognition and prompt intervention. ABSTRACT: Sepsis is a leading cause of critical illness and hospital mortality. Early recognition and intervention are essential for the survival of patients with this syndrome. In 2002, the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM) launched the Surviving Sepsis Campaign (SSC) to reduce overall patient morbidity and mortality from sepsis and septic shock by driving practice initiatives based on current best evidence...
January 11, 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29326030/patient-reported-outcomes-following-abiraterone-acetate-plus-prednisone-added-to-androgen-deprivation-therapy-in-patients-with-newly-diagnosed-metastatic-castration-naive-prostate-cancer-latitude-an-international-randomised-phase-3-trial
#17
Kim N Chi, Andrew Protheroe, Alfredo Rodríguez-Antolín, Gaetano Facchini, Henrik Suttman, Nobuaki Matsubara, Zhangqun Ye, Bhumsuk Keam, Ronaldo Damião, Tracy Li, Kelly McQuarrie, Bin Jia, Peter De Porre, Jason Martin, Mary B Todd, Karim Fizazi
BACKGROUND: In the LATITUDE trial, addition of abiraterone acetate plus prednisone to androgen deprivation therapy (ADT) improved overall survival compared with placebos plus ADT in patients with newly diagnosed, high-risk, metastatic castration-naive prostate cancer. Understanding the effects of treatments on patient-reported outcomes (PROs) and health-related quality of life (HRQOL) is important for treatment decisions; therefore we aimed to analyse the effects of ADT plus abiraterone acetate and prednisone versus ADT plus placebos on PROs and HRQOL in patients in the LATITUDE study...
January 8, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29324538/specific-regions-rather-than-the-entire-peritoneal-carcinosis-index-are-predictive-of-complete-resection-and-survival-in-advanced-epithelial-ovarian-cancer
#18
Mikkel Rosendahl, Philipp Harter, Signe Frahm Bjørn, Claus Høgdall
BACKGROUND: Advanced epithelial ovarian cancer (EOC) often involves the peritoneum. Because complete resection of tumor and carcinosis is the most important prognostic factor, the peritoneal carcinosis index (PCI) has been evaluated in EOC. We hypothesize that specific PCI regions comprising the small intestine with mesentery (regions 9-12) and the hepatoduodenal ligament (region 2) are more predictive of complete resection (R = 0) and survival than the entire PCI. MATERIALS AND METHODS: We analyzed prospectively collected nationwide data from 507 patients with International Federation of Gynecology and Obstetrics stage IIIB to IVB EOC who underwent primary surgery with complete cytoreductive intent...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324537/the-figo-stage-iva-versus-ivb-of-ovarian-cancer-prognostic-value-and-predictive-value-for-neoadjuvant-chemotherapy
#19
Parvin Tajik, Roelien van de Vrie, Mohammad H Zafarmand, Corneel Coens, Marrije R Buist, Ignace Vergote, Patrick M M Bossuyt, Gemma G Kenter
OBJECTIVE: The revised version of the International Federation of Gynaecology and Obstetrics (FIGO) staging system (2014) for epithelial ovarian cancer includes a number of changes. One of these is the division of stage IV into 2 subgroups. Data on the prognostic and predictive significance of this classification are scarce. The effect of neoadjuvant chemotherapy (NACT) versus primary debulking surgery (PDS) in relation to the subclassification of FIGO stage IV is also unknown. METHODS: We used data of the EORTC 55971 trial, in which 670 patients with previous stage IIIC or IV epithelial ovarian cancer were randomly assigned to PDS or NACT; 160 patients had previous stage IV...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324532/low-expression-of-protocadherin-8-promotes-the-progression-of-ovarian-cancer
#20
Yuan Cao, Yan Yu, Xiaolong Chen, Fang Ren, Ruitao Zhang, Yanyan Jia, Zhigang Ren, Ranran Sun, Juan Li, Huirong Shi
OBJECTIVE: Ovarian cancer (OC) is the second most lethal gynecological cancer among women throughout the world. Protocadherin-8 (PCDH8) could function as a candidate tumor suppressor. However, the link between PCDH8 and OC development is poorly understood. MATERIALS AND METHODS: A total of 68 OC patients were retrospectively enrolled. Clinical information was collected and cancer tissues were used for tissue microarray. The PCDH8 expression was determined on tissue microarray by immunohistochemical staining, and PCDH8 protein was detected in cancer tissues and adjacent tissue by western blotting...
January 10, 2018: International Journal of Gynecological Cancer
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