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https://www.readbyqxmd.com/read/29444728/the-long-term-effects-of-the-deepwater-horizon-oil-spill-on-women-s-depression-and-mental-distress
#1
Ariane Lisann Rung, Evrim Oral, Elizabeth Fontham, Daniel J Harrington, Edward J Trapido, Edward S Peters
OBJECTIVE: The purpose of the study is to describe changes in mental health among women following an oil spill and to examine their association with the Deepwater Horizon oil spill (DHOS). METHODS: The Women and Their Children's Health study followed 2038 women in Louisiana after the DHOS. Subjects were interviewed in 2012-2014 and 2014-2016. Oil spill exposure was characterized using survey items about economic and physical exposures. Outcomes were depressive symptoms and mental distress...
February 15, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29425763/buccal-drug-delivery-technologies-for-patient-centred-treatment-of-radiation-induced-xerostomia-dry-mouth
#2
REVIEW
Osamah S Malallah, Cristina M Aller Garcia, Gordon B Proctor, Ben Forbes, Paul G Royall
Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomia) because of radiation-induced damage to their salivary glands. Patients with xerostomia suffer symptoms that severely affect their health as well as physical, social and emotional aspects of their life. The current management of xerostomia is the application of saliva substitutes or systemic delivery of saliva-stimulating cholinergic agents, including pilocarpine, cevimeline or bethanechol tablets...
February 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29422195/practice-based-interpretation-of-ultrasound-studies-leads-the-way-to-more-effective-clinical-support-and-less-pharmaceutical-and-surgical-intervention-for-breastfeeding-infants
#3
REVIEW
Pamela Douglas, Donna Geddes
BACKGROUND: breastfeeding optimises health outcomes for both mothers and infants. Although most women want to breastfeed, they report commencing infant formula because of nipple pain, unsettled infant behaviour, and infant growth concerns. To date, existing approaches to fit and hold ('latch and positioning') have been demonstrated not to help breastfeeding outcomes, and women report widespread dissatisfaction with the quality of support and conflicting advice they receive. Breast and nipple pain, difficulty with latching and sucking, fussing at the breast, back-arching, marathon feeds, excessively frequent feeds, poor weight gain, breast refusal, and crying due to poor satiety often signal suboptimal positional instability and impaired milk transfer, but may be misdiagnosed as medical conditions...
March 2018: Midwifery
https://www.readbyqxmd.com/read/29417862/nanomaterials-in-dentistry-a-cornerstone-or-a-black-box
#4
Rafał Pokrowiecki, Krzysztof Pałka, Agnieszka Mielczarek
AIM: The studies on tooth structure provided basis for nanotechnology-based dental treatment approaches known as nanodentistry which aims at detection and treatment of oral pathologies, such as dental caries and periodontal diseases, insufficiently being treated by conventional materials or drugs. This review aims at defining the role of nanodentistry in the medical area, its potential and hazards. MATERIALS & METHODS: To validate these issues, current literature on nanomaterials for dental applications was critically reviewed...
February 8, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29408543/precision-medicine-in-cow-milk-allergy-proteomics-perspectives-from-allergens-to-patients
#5
Enza D' Auria, Chiara Mameli, Cristian Piras, Lucia Cococcioni, Andrea Urbani, Gian Vincenzo Zuccotti, Paola Roncada
Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment are critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years...
February 3, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29406840/prostacyclin-use-among-patients-with-pulmonary-arterial-hypertension-in-the-united-states-a-retrospective-analysis-of-a-large-health-care-claims-database
#6
Charles D Burger, Janis A Pruett, Cassandra A Lickert, Ariel Berger, Brian Murphy, William Drake
BACKGROUND: Prostacyclins play an important role in the management of pulmonary arterial hypertension (PAH). Intravenous prostacyclin was the first disease-specific treatment for patients with PAH. Subcutaneous and nonparenteral (oral or inhaled) formulations have subsequently become available. However, data are lacking on how these different prostacyclin formulations are being used in clinical practice. OBJECTIVES: To (a) conduct retrospective analyses of a large U...
December 18, 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29402108/the-evolution-of-the-kelley-community-capacity-development-model-for-palliative-care
#7
Mary Lou Kelley
This oral presentation will describe the conceptual evolution of the Kelley model for Community Capacity Development [2000-2016]. It will illustrate how and why the model changed to become a powerful Canadian example of a public health approach to developing community based palliative care programs. Based on conducting participatory action research in rural, First Nations communities and long-term care homes, the perspective of "community" gradually expanded beyond health care professionals to include natural helpers, front line care providers, formal and informal community leaders, and social services...
January 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29394879/dysbiotic-biofilms-deregulate-the-periodontal-inflammatory-response
#8
E R Herrero, S Fernandes, T Verspecht, E Ugarte-Berzal, N Boon, P Proost, K Bernaerts, M Quirynen, W Teughels
Periodontal diseases originate from a dysbiosis within the oral microbiota, which is associated with a deregulation of the host immune response. Although little is known about the initiation of dysbiosis, it has been shown that H2O2 production is one of the main mechanisms by which some commensal bacteria suppress the outgrowth of pathobionts. Current models emphasize the critical nature of complex microbial biofilms that form unique microbial ecologies and of their change during transition from health (homeostatic) to disease (dysbiotic)...
February 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29382353/laquinimod-attenuates-inflammation-by-modulating-macrophage-functions-in-traumatic-brain-injury-mouse-model
#9
Atsuko Katsumoto, Aline S Miranda, Oleg Butovsky, Antônio L Teixeira, Richard M Ransohoff, Bruce T Lamb
BACKGROUND: Traumatic brain injury (TBI) is a critical public health and socio-economic problem worldwide. A growing body of evidence supports the involvement of inflammatory events in TBI. It has been reported that resident microglia and infiltrating monocytes promote an inflammatory reaction that leads to neuronal death and eventually behavioral and cognitive impairment. Currently, there is no effective treatment for TBI and the development of new therapeutic strategies is a scientific goal of highest priority...
January 30, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29378547/the-research-and-evaluation-of-antipsychotic-treatment-in-community-behavioral-health-organizations-outcomes-reach-out-study-real-world-clinical-practice-in-schizophrenia
#10
Kruti Joshi, Lian Mao, David M Biondi, Robert Millet
BACKGROUND: Outpatient facilities, such as community behavioral health organizations (CBHOs), play a critical role in the care of patients with serious mental illness, but there is a paucity of "real-world" patient outcomes data from this health care setting. Therefore, we conducted The Research and Evaluation of Antipsychotic Treatment in Community Behavioral Health Organizations, Outcomes (REACH-OUT) trial, a real-world, prospective, noninterventional observational study of patients with mental illness treated at CBHOs across the United States...
January 29, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29370676/a-clinical-update-on-metformin-and-lung-cancer-in-diabetic-patients
#11
Gaurav Gupta, Terezinha de Jesus Andreoli Pinto, Dinesh K Chellappan, Anurag Mishra, Himaja Malipeddi, Kamal Dua
Diabetes mellitus (DM) is frequently increased in many countries and become a serious health problem worldwide. Diabetes is associated with dysfunction of different organs such as heart, eyes, blood vessels, nerves, and kidneys. There is a strong connection between diabetes and cancer. Metformin is one of the most commonly prescribed oral antidiabetic medicines and it is suggested as the firstline therapy due to its comparatively safe, inexpensive, effective and welltolerated. Some of the in vitro and in vivo investigations proved that metformin may have a direct anticancer action by preventing the proliferation of malignant cells and formations of the colony, inducing arrest of cell cycle and apoptosis and suppressing tumour growth...
January 25, 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29365082/early-microbial-colonization-affects-dna-methylation-of-genes-related-to-intestinal-immunity-and-metabolism-in-preterm-pigs
#12
Xiaoyu Pan, Desheng Gong, Duc Ninh Nguyen, Xinxin Zhang, Qi Hu, Hanlin Lu, Merete Fredholm, Per T Sangild, Fei Gao
Epigenetic regulation may play an important role in mediating microbe-host interactions and adaptation of intestinal gene expression to bacterial colonization just after birth. This is particularly important after preterm birth because the immature intestine is hypersensitive to invading bacteria. We compared the intestinal DNA methylome and microbiome between conventional (CON) and antibiotics-treated (AB) preterm pigs, used as a model for preterm infants. Oral AB treatment reduced bacterial density (∼100-fold), diversity and fermentation, improved the resistance to necrotizing enterocolitis (NEC) and changed the genome-wide DNA methylation in the distal small intestine...
January 19, 2018: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29364253/oral-biofilm-sampling-for-microbiome-analysis-in-healthy-children
#13
Elisabeth Santigli, Martin Koller, Barbara Klug
Oral biofilm and its molecular analysis provide a basis for investigating various dental research and clinical questions. Knowledge of biofilm composition leads to a better understanding of cariogenic and periopathogenic mechanisms. Microbial changes taking place in the oral cavity during childhood are of interest for several reasons. The evolution of the child oral microbiota and shifts in its composition need to be analyzed further to understand and possibly prevent the onset of disease. At the same time, advanced knowledge of the natural composition of oral biofilm is needed...
December 31, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29361733/verdinexor-targeting-of-crm1-is-a-promising-therapeutic-approach-against-rsv-and-influenza-viruses
#14
REVIEW
Jennifer A Pickens, Ralph A Tripp
Two primary causes of respiratory tract infections are respiratory syncytial virus (RSV) and influenza viruses, both of which remain major public health concerns. There are a limited number of antiviral drugs available for the treatment of RSV and influenza, each having limited effectiveness and each driving selective pressure for the emergence of drug-resistant viruses. Novel broad-spectrum antivirals are needed to circumvent problems with current disease intervention strategies, while improving the cytokine-induced immunopathology associated with RSV and influenza infections...
January 21, 2018: Viruses
https://www.readbyqxmd.com/read/29355414/the-caries-microbiome-implications-for-reversing-dysbiosis
#15
A C R Tanner, C A Kressirer, S Rothmiller, I Johansson, N I Chalmers
The oral microbiome plays a critical role in maintaining oral health. Frequent dietary carbohydrate intake can lead to dysbiosis of the microbial community from overproduction of acid with selection for increases in acidogenic, acid-tolerant bacteria. Knowledge of the caries-associated microbiome is key in planning approaches to reverse the dysbiosis to achieve health. For risk assessment and treatment studies, it would be valuable to establish whether microbial monitoring requires assay of multiple species or whether selected key species would suffice...
February 2018: Advances in Dental Research
https://www.readbyqxmd.com/read/29348572/areca-nut-extracts-mobilize-calcium-and-release-pro-inflammatory-cytokines-from-various-immune-cells
#16
Malika Faouzi, Ram P Neupane, Jian Yang, Philip Williams, Reinhold Penner
Betel nut consumption has significant implications for the public health globally, as the wide-spread habit of Areca chewing throughout Asia and the Pacific is associated with a high prevalence of oral carcinoma and other diseases. Despite a clear causal association of betel nut chewing and oral mucosal diseases, the biological mechanisms that link Areca nut-contained molecules, inflammation and cancer remain underexplored. In this study we show that the whole Areca nut extract (ANE) is capable of mobilizing Ca2+ in various immune cell lines...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29346340/disparities-in-preconception-health-indicators-%C3%A2-behavioral-risk-factor-surveillance-system-2013-2015-and-pregnancy-risk-assessment-monitoring-system-2013-2014
#17
Cheryl Robbins, Sheree L Boulet, Isabel Morgan, Denise V D'Angelo, Lauren B Zapata, Brian Morrow, Andrea Sharma, Charlan D Kroelinger
PROBLEM/CONDITION: Preconception health is a broad term that encompasses the overall health of nonpregnant women during their reproductive years (defined here as aged 18-44 years). Improvement of both birth outcomes and the woman's health occurs when preconception health is optimized. Improving preconception health before and between pregnancies is critical for reducing maternal and infant mortality and pregnancy-related complications. The National Preconception Health and Health Care Initiative's Surveillance and Research work group suggests ten prioritized indicators that states can use to monitor programs or activities for improving the preconception health status of women of reproductive age...
January 19, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29309550/hormonal-contraception-and-hiv-1-acquisition-biological-mechanisms
#18
Janet P Hapgood, Charu Kaushic, Zdenek Hel
Access to effective affordable contraception for women is critical for individual and public health. A wide range of hormonal contraceptives (HCs) which differ in the composition, concentration of progestin component, frequency of dosage and method of administration, is currently available globally. However, the options are rather limited in settings with restricted economic resources that frequently overlap with areas of high HIV-1 prevalence. The predominant contraceptive used in Sub-Saharan Africa is the progestin-only three-monthly injectable depo-medroxyprogesterone acetate (DMPA)...
January 4, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29308590/laboratory-based-testing-to-evaluate-abuse-deterrent-formulations-and-satisfy-the-food-and-drug-administration-s-recommendation-for-category-1-testing
#19
Christopher Altomare, Eric R Kinzler, August R Buchhalter, Edward J Cone, Anthony Costantino
The US Food and Drug Administration (FDA) considers the development of abuse-deterrent formulations of solid oral dosage forms a public health priority and has outlined a series of premarket studies that should be performed prior to submitting an application to the Agency. Category 1 studies are performed to characterize whether the abuse-deterrent properties of a new formulation can be easily defeated. Study protocols are designed to evaluate common abuse patterns of prescription medications as well as more advanced methods that have been reported on drug abuse websites and forums...
November 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/29299731/micrornas-as-effective-surrogate-biomarkers-for-early-diagnosis-of-oral-cancer
#20
REVIEW
Min Cao, Lijuan Zheng, Jianzhou Liu, Thomas Dobleman, Shen Hu, Vay Liang W Go, Ge Gao, Gary Guishan Xiao
BACKGROUND: Oral squamous cell carcinomas (OC) are life-threatening diseases emerging as major international health concerns. OBJECTIVE: Development of an efficient clinical strategy for early diagnosis of the disease is a key for reducing the death rate. Biomarkers are proven to be an effective approach for clinical diagnosis of cancer. Although mechanisms underlying regulation of oral malignancy are still unclear, microRNAs (miRNAs) as a group of small non-coded RNAs may be developed as the effective biomarkers used for early detection of oral cancer...
January 3, 2018: Clinical Oral Investigations
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