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https://www.readbyqxmd.com/read/29628170/preoperative-assessment-of-the-risk-of-postoperative-death-in-patients-with-oral-squamous-cell-carcinoma-a-consideration-beyond-age-sex-and-stage-of-cancer
#1
A K Bartella, A-K Sander, M Kamal, J Steegmann, A Kloss-Brandstätter, J Teichmann, F Hölzle, B Lethaus
Despite improvements in the management of patients in critical care, about 3% patients who have an operation with curative intent for oral squamous cell carcinoma (SCC) do not survive their stay in hospital. Our aim was to assess the risk factors for postoperative death that were independent of the stage of the cancer, or the age and sex of the patients. We screened 4760 consecutive inpatients at a maxillofacial tertiary care centre from 2011 to 2016, and 34 of them had died within the first three months after operation...
April 5, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29625029/how-much-noise-is-an-oral-and-maxillofacial-surgeon-exposed-to
#2
Esha Kulkarni, Yasmine Abdallah, Dennis Hanseman, Deepak G Krishnan
PURPOSE: A common concern among oral and maxillofacial surgeons (OMSs) is progressive hearing loss throughout their careers. Although this has not been critically studied, there could be several factors that contribute to this detriment, including drills, saws, suction, music, and other sounds within the closed operating environment. This study observed the intensity of noise in operating rooms (ORs) and clinical settings during the use of drills, saws, surgical handpieces, and other tools...
March 14, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29603328/critical-review-of-the-validity-of-patient-satisfaction-questionnaires-pertaining-to-oral-health-care
#3
Rahul Nair, Sana Ishaque, Andrew John Spencer, Liana Luzzi, Loc Giang Do
OBJECTIVES: Review the validation process reported for oral healthcare satisfaction scales that intended to measure general oral health care that is not restricted to specific subspecialties or interventions. METHODS: After preliminary searches, PUBMED and EMBASE were searched using a broad search strategy, followed by a snowball strategy using the references of the publications included from database searches. Title and abstract were screened for assessing inclusion, followed by a full-text screening of these publications...
March 30, 2018: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29602225/oral-microbiota-maturation-during-the-first-7-years-of-life-in-relation-to-allergy-development
#4
Majda Dzidic, Thomas Abrahamsson, Alejandro Artacho, Maria Carmen Collado, Alex Mira, Maria C Jenmalm
BACKGROUND: Allergic diseases have become a major public health problem in affluent societies. Microbial colonization early in life seems to be critical for instructing regulation on immune system maturation and allergy development in children. Even though the oral cavity is the first site of encounter between a majority of foreign antigens and the immune system, the influence of oral bacteria on allergy development has not yet been reported. OBJECTIVE: We sought to determine the bacterial composition in longitudinally collected saliva samples during childhood in relation to allergy development...
March 30, 2018: Allergy
https://www.readbyqxmd.com/read/29588606/cost-utility-budget-impact-and-scenario-analysis-of-racecadotril-in-addition-to-oral-rehydration-for-acute-diarrhea-in-children-in-malaysia
#5
Tamlyn Anne Rautenberg, Ute Zerwes, Way Seah Lee
Objective: To perform cost utility (CU) and budget impact (BI) analyses augmented by scenario analyses of critical model structure components to evaluate racecadotril as adjuvant to oral rehydration solution (ORS) for children under 5 years with acute diarrhea in Malaysia. Methods: A CU model was adapted to evaluate racecadotril plus ORS vs ORS alone for acute diarrhea in children younger than 5 years from a Malaysian public payer's perspective. A bespoke BI analysis was undertaken in addition to detailed scenario analyses with respect to critical model structure components...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29582405/ixazomib-for-relapsed-or-refractory-multiple-myeloma-review-from-an-evidence-review-group-on-a-nice-single-technology-appraisal
#6
REVIEW
Xavier Armoiry, Martin Connock, Alexander Tsertsvadze, Ewen Cummins, G J Melendez-Torres, Pam Royle, Aileen Clarke
Ixazomib is an oral proteasome inhibitor used in combination with lenalidomide plus dexamethasone (IXA-LEN-DEX) and licensed for relapsed or refractory multiple myeloma. As part of a single technology appraisal (ID807) undertaken by the National Institute of Health and Care Excellence, the Evidence Review Group, Warwick Evidence was invited to independently review the evidence submitted by the manufacturer of ixazomib, Takeda UK Ltd. The main source of clinical effectiveness data about IXA-LEN-DEX came from the Tourmaline-MM1 randomized controlled trial in which 771 patients with relapsed or refractory multiple myeloma received either IXA-LEN-DEX or placebo-LEN-DEX as their second-, third-, or fourth-line treatment...
March 26, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29574814/extractions-to-reconstruction-the-development-of-oral-maxillofacial-surgery-in-australian-and-new-zealand
#7
A N Goss, R Linn
Oral and Maxillofacial Surgery developed initially from Dentistry as exodontia. It then expanded into the surgical management of jaw disorders. As the specialty evolved, it came into increasing conflict with related surgical disciplines. In the 1960s and 1970s these external criticisms were well-founded as training in oral surgery was individual, solely University-based and highly variable. In the 1980s the speciality developed a plan which involved hospital-based surgical training, a mandatory high level college surgical examination and detailed workforce and training studies...
March 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29574808/oral-cancer
#8
Tsc Wong, D Wiesenfeld
The management of oral cancer is a multidisciplinary endeavour, as each patient presents the treating clinicians with a unique set of challenges the management of which impacts on both survival and quality of life. This article focuses on the management of oral cancer. We highlight the epidemiology and risk factors for oral cancer in Australia, the various clinical presentations that occur and the staging of oral cancer. In the vast majority of cases surgery remains the mainstay of treatment. Radiation and medical oncology is usually used in an adjuvant context...
March 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29563833/evolution-of-regorafenib-from-bench-to-bedside-in-colorectal-cancer-is-it-an-attractive-option-or-merely-a-me-too-drug
#9
REVIEW
Gaurav Goel
Colorectal cancer (CRC) is a major public health problem in the United States with an estimated 50,260 deaths in 2017. Over the past two decades, several agents have been approved by the US Food and Drug Administration (FDA) for the treatment of patients with metastatic CRC (mCRC). Regorafenib (BAY 73-4506) is a small-molecule multikinase inhibitor that was approved for the treatment of mCRC in 2012. This agent is a novel oral diphenylurea-based multikinase inhibitor that is active against several angiogenic receptor tyrosine kinases (RTKs; VEGFR-1, VEGFR-2, VEGFR-3, TIE-2), oncogenic RTKs (c-KIT, RET), stromal RTKs (PDGFR-B, FGFR-1), and intracellular signaling kinases (c-RAF/RAF-1, BRAF, BRAFV600E )...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29546357/teaching-epidemiology-at-the-undergraduate-level-considerations-and-approaches
#10
Emily Goldmann, James H Stark, Farzana Kapadia, Matthew B McQueen
The rapid growth in undergraduate public health education has offered an increasing number of undergraduate students training in epidemiology. Epidemiology courses introduce undergraduate students to a population health perspective and provide opportunities for these students to build essential skills and competencies such as ethical reasoning, teamwork, comprehension of scientific methods, critical thinking, quantitative and information literacy, ability to analyze public health information, and effective writing and oral communication...
March 13, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29520556/using-community-driven-participatory-qualitative-inquiry-to-discern-nuanced-community-health-needs-and-assets-of-chicago-s-la-villita-a-mexican-immigrant-neighborhood
#11
Jennifer Hebert-Beirne, Sarah Gabriella Hernandez, Jennifer Felner, Jessica Schwiesow, Anna Mayer, Kevin Rak, Noel Chávez, Yvette Castañeda, Joan Kennelly
In predominately immigrant neighborhoods, the nuances of immigrant life in the ethnic enclave have important, yet underappreciated impact on community health. The complexities of immigrant experiences are essential to unpacking and addressing the impact of acculturative processes on observed racial, ethnic, and class-based health disparities in the United States. These insights because they are largely unexplored are best captured qualitatively through academic-community research partnership. We established the participatory mixed method Little Village participatory community health assessment (CHA) to explore community health in an ethnic enclave...
March 8, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29511826/efficacy-and-safety-of-amantadine-for-the-treatment-of-l-dopa-induced-dyskinesia
#12
REVIEW
Santiago Perez-Lloret, Olivier Rascol
L-DOPA induced dyskinesias (LIDs) may affect up to 40% of Parkinson's disease (PD) and impact negatively health-related quality of life. Amantadine has demonstrated significant antidyskinetic effects in animal PD models and in randomized double-blind placebo-controlled trials (RCTs) in patients with PD. These effects are thought to be related to the blockade of NMDA receptors modulating cortico-striatal glutamatergic-dopaminergic interactions involved in the genesis of LIDs. There are three pharmaceutical forms of amantadine currently available in the market: an oral immediate-release (IR) formulation, which is widely available; an extended-release (ER) formulation (ADS-5102) which has been recently developed and approved by the FDA; and an intravenous infusion (IV) solution, which is not commonly used in clinical practice...
March 7, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29505322/activation-of-stimulator-of-interferon-genes-sting-and-sj%C3%A3-gren-syndrome
#13
J Papinska, H Bagavant, G B Gmyrek, M Sroka, S Tummala, K A Fitzgerald, U S Deshmukh
Sjögren syndrome (SS), a chronic autoimmune disorder causing dry mouth, adversely affects the overall oral health in patients. Activation of innate immune responses and excessive production of type I interferons (IFNs) play a critical role in the pathogenesis of this disorder. Recognition of nucleic acids by cytosolic nucleic acid sensors is a major trigger for the induction of type I IFNs. Upon activation, cytosolic DNA sensors can interact with the stimulator of interferon genes (STING) protein, and activation of STING causes increased expression of type I IFNs...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29502456/doing-histor-y-ies-of-health-psycholog-y-ies
#14
Ian Lubek, Michael Murray
Academic (sub)disciplines develop in time and place when particular ideas/practices are nurtured within social, gendered, cultural, community, economic and political contexts. Different histories employ different analyses, some with external views of scientific outputs describing research and practice, and others with internal, behind-the-scenes examinations of these developments, through oral histories and personal recollections. This collection, written by historians of (social) science, or practitioners or pioneering participants, uses different historiographical methods to contextualize health-related activities within the sub-discipline of health psychology and the evolving critical and/or community approaches...
March 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29498792/using-salivary-glands-to-treat-serious-systemic-diseases-sexamples-of-new-roles-for-oral-medicine-in-the-health-care-team
#15
Bruce J Baum
It is necessary to begin this Commentary with a very significant disclaimer. I have extensively published on and extolled the merits of using gene transfer to salivary glands as a means for turning these critically important oral tissues into valuable in vivo bioreactors to make therapeutic proteins for systemic use (e.g., Voutetakis et al, 2004; Hai et al, 2009; Perez et al, 2010). This article is protected by copyright. All rights reserved.
March 2, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29494484/the-burden-of-fungal-diseases-in-romania
#16
Mihai Mareș, Valentina Ruxandra Moroti-Constantinescu, David W Denning
OBJECTIVE: To estimate for the first time the burden of fungal infections in Romania. METHODS: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations, and published annual reports on local epidemiology were used in the present study. When no data were available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters...
March 1, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29492400/a-protocol-for-a-feasibility-and-acceptability-study-of-a-participatory-multi-level-dynamic-intervention-in-urban-outreach-centers-to-improve-the-oral-health-of-low-income-chinese-americans
#17
Mary E Northridge, Sara S Metcalf, Stella Yi, Qiuyi Zhang, Xiaoxi Gu, Chau Trinh-Shevrin
Introduction: While the US health care system has the capability to provide amazing treatment of a wide array of conditions, this care is not uniformly available to all population groups. Oral health care is one of the dimensions of the US health care delivery system in which striking disparities exist. More than half of the population does not visit a dentist each year. Improving access to oral health care is a critical and necessary first step to improving oral health outcomes and reducing disparities...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29469999/a-systematic-review-and-meta-analysis-of-baseline-ohip-edent-scores
#18
J M J Duale, Y A Patel, J Wu, T P Hyde
BACKGROUND: OHIP-EDENT is widely used in the literature to assess Oral-Health-Related-Quality-of-Life (OHRQoL) for edentulous patients. However the normal variance and mean of the baseline OHIP scores has not been reported. It would facilitate critical appraisal of studies if we had knowledge of the normal variation and mean of baseline OHIP-EDENT scores. An established figure for baseline OHIP-EDENT, obtained from a meta-analysis, would simplify comparisons of studies and quantify variations in initial OHRQoL of the trial participants...
March 1, 2018: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/29463651/n-glycosylation-of-viral-e-protein-is-the-determinant-for-vector-midgut-invasion-by-flaviviruses
#19
Dan Wen, Suhua Li, Fangfang Dong, Yanan Zhang, Yongfang Lin, Jumei Wang, Zhen Zou, Aihua Zheng
Transmission of flaviviruses by hematophagous insects such as mosquitoes requires acquisition of the virus during blood feeding on the host, with midgut as the primary infection site. Here, we report that N-glycosylation of the E protein, which is conserved among most flaviviruses, is critical for the Zika virus (ZIKV) to invade the vector midgut by inhibiting the reactive oxygen species (ROS) pathway of the mosquito immune system. Our data further show that removal of the ZIKV E glycosylation site prevents mosquito infection by flaviviruses via the oral route, whereas there is no effect on infection by intrathoracic microinjection, which bypasses the midgut...
February 20, 2018: MBio
https://www.readbyqxmd.com/read/29463305/lysozyme-improves-gut-performance-and-protects-against-enterotoxigenic-escherichia-coli-infection-in-neonatal-piglets
#20
Guangping Huang, Xiangqing Li, Dan Lu, Shen Liu, Xun Suo, Qiuyan Li, Ning Li
Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for diarrhea that do not involve chemotherapeutic drugs or result in antibiotic resistance is critical. Considering that lysozyme is a naturally occurring antimicrobial peptide, in a previous study we developed a transgenic pig line that expresses recombinant human lysozyme (hLZ) in its milk. In the present study, we examined the protective effects of the consumption of this milk against ETEC infection in neonatal piglets...
February 20, 2018: Veterinary Research
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