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https://www.readbyqxmd.com/read/28453588/-diverticular-disease-myths-and-realities
#1
Daniela Fluxá, Rodrigo Quera
Diverticulosis and diverticular disease of the colon are common conditions in Western countries. The incidence and prevalence of these diseases are increasing and becoming significant for health systems. A growing body of knowledge is shifting the paradigm of the pathogenesis and treatment of diverticular disease. Low-grade inflammation, altered intestinal microbiota, visceral hypersensitivity, and abnormal colonic motility have been identified as factors leading to diverticular disease. The risk of developing diverticulitis among individuals with diverticulosis is lower than 10 to 25%...
February 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28453472/the-2002-nimh-provisional-diagnostic-criteria-for-depression-of-alzheimer-s-disease-pdc-dad-gauging-their-validity-over-a-decade-later
#2
Amir A Sepehry, Philip E Lee, Ging-Yuek R Hsiung, B Lynn Beattie, Howard H Feldman, Claudia Jacova
Presented herein is evidence for criterion, content, and convergent/discriminant validity of the NIMH-Provisional Diagnostic Criteria for depression of Alzheimer's Disease (PDC-dAD) that were formulated to address depression in Alzheimer's disease (AD). Using meta-analytic and systematic review methods, we examined criterion validity evidence in epidemiological and clinical studies comparing the PDC-dAD to Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV), and International Classification of Disease (ICD 9) depression diagnostic criteria...
April 28, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28449376/psychological-distress-and-widespread-pain-contribute-to-the-variance-of-the-central-sensitization-inventory-a-cross-sectional-study-in-patients-with-chronic-pain
#3
C P van Wilgen, P J Vuijk, J Kregel, L Voogt, M Meeus, F Descheemaker, D Keizer, J Nijs
OBJECTIVES: Central sensitization (CS) implies increased sensitivity of the nervous system, resulting in increased pain sensitivity as well as widespread pain. Recently, the Central Sensitization Inventory (CSI) was developed to assess symptoms of CS and central sensitivity syndromes. The aim of this study was to examine the convergent validity of the CSI by comparing the outcome to psychosocial factors and clinical features of CS. METHODS: In a cross-sectional explorative study, patients with chronic pain completed multiple questionnaires, including the CSI, pain catastrophizing scale, SCL-90 for psychological distress, duration of pain, intensity of pain, widespread pain, and lateralization of pain...
April 27, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28449247/informant-discrepancy-defines-discrete-clinically-useful-autism-spectrum-disorder-subgroups
#4
Matthew D Lerner, Andres De Los Reyes, Deborah A G Drabick, Alan H Gerber, Kenneth D Gadow
BACKGROUND: Discrepancy between informants (parents and teachers) in severity ratings of core symptoms commonly arise when assessing autism spectrum disorder (ASD). Whether such discrepancy yields unique information about the ASD phenotype and its clinical correlates has not been examined. We examined whether degree of discrepancy between parent and teacher ASD symptom ratings defines discrete, clinically meaningful subgroups of youth with ASD using an efficient, cost-effective procedure...
April 27, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28449235/psychometric-properties-of-the-mental-health-and-social-inadaptation-assessment-for-adolescents-mia-in-a-population-based-sample
#5
Sylvana M Côté, Massimiliano Orri, Mara Brendgen, Frank Vitaro, Michel Boivin, Christa Japel, Jean R Séguin, Marie-Claude Geoffroy, Alexandra Rouquette, Bruno Falissard, Richard E Tremblay
We report on the psychometric properties of the Mental Health and Social Inadaptation Assessment for Adolescents (MIA), a self-report instrument for quantifying the frequency of mental health and psychosocial adaptation problems using a dimensional approach and based on the DSM-5. The instrument includes 113 questions, takes 20-25 minutes to answer, and covers the past 12 months. A population-based cohort of adolescents (n = 1443, age = 15 years; 48% males) rated the frequency at which they experienced symptoms of Attention Deficit Hyperactivity Disorder (ADHD), Conduct Disorder, Oppositional Defiant Disorder, Depression, Generalized Anxiety, Social Phobia, Eating Disorders (i...
April 27, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28448672/correlation-between-the-inflammatory-marker-hla-dr-and-signs-and-symptoms-in-moderate-to-severe-dry-eye-disease
#6
Françoise Brignole-Baudouin, Luisa Riancho, Dahlia Ismail, Maëva Deniaud, Mourad Amrane, Christophe Baudouin
Purpose: To investigate correlations of the inflammatory HLA-DR marker with clinical signs and symptoms commonly used to assess dry eye disease (DED) severity. Methods: Baseline data were collected from three clinical studies conducted on moderate to severe DED patients. Characteristics of DED were analyzed and correlations were performed in 311 patients. Data were analyzed after treatment with 1 mg/mL cyclosporine (CsA) and vehicle. We quantified HLA-DR by flow cytometry in impression cytology specimens...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28448160/validation-of-anam-for-cognitive-screening-in-a-mixed-clinical-sample
#7
Andrea S Vincent, Tresa M Roebuck-Spencer, L Eugenia Cox-Fuenzalida, Cady Block, James G Scott, Robert Kane
The Automated Neuropsychological Assessment Metrics (ANAM) is a library of computer based tests designed to measure cognitive function at a single time-point or longitudinally for detection of cognitive change. This study sought to validate ANAM as a cognitive screening tool for presence of confirmed neuropsychological diagnosis in an outpatient setting. Retrospective data analysis was conducted for 139 patients referred for outpatient neuropsychological assessment. Clinical diagnosis was made independent of ANAM test results and resulted in a diagnostic mix of both neurologic and psychologic etiologies...
April 27, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28446871/prevalence-of-joint-gait-patterns-defined-by-a-delphi-consensus-study-is-related-to-gross-motor-function-topographical-classification-weakness-and-spasticity-in-children-with-cerebral-palsy
#8
Angela Nieuwenhuys, Eirini Papageorgiou, Simon-Henri Schless, Tinne De Laet, Guy Molenaers, Kaat Desloovere
During a Delphi consensus study, a new joint gait classification system was developed for children with cerebral palsy (CP). This system, whose reliability and content validity have previously been established, identified 49 distinct joint patterns. The present study aims to provide a first insight toward the construct validity and clinical relevance of this classification system. The retrospective sample of convenience consisted of 286 patients with spastic CP (3-18 years old, GMFCS levels I-III, 166 with bilateral CP)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28446367/problematic-social-media-use-and-depressive-symptoms-among-u-s-young-adults-a-nationally-representative-study
#9
Ariel Shensa, César G Escobar-Viera, Jaime E Sidani, Nicholas D Bowman, Michael P Marshal, Brian A Primack
RATIONALE: Depression is the leading cause of disability worldwide. The suggested association between social media use (SMU) and depression may be explained by the emerging maladaptive use pattern known as problematic social media use (PSMU), characterized by addictive components. OBJECTIVE: We aimed to assess the association between PSMU and depressive symptoms-controlling for overall time and frequency of SMU-among a large sample of U.S. young adults. METHODS: In October 2014, participants aged 19-32 (N = 1749) were randomly selected from a nationally-representative U...
April 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28446011/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-ii-external-validation-and-usability-testing-of-a-smartphone-app
#10
Min Soo Choo, Seong Jin Jeong, Sung Yong Cho, Changwon Yoo, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: We aimed to externally validate the prediction model we developed for having bladder outlet obstruction (BOO) and requiring prostatic surgery using 2 independent data sets from tertiary referral centers, and also aimed to validate a mobile app for using this model through usability testing. METHODS: Formulas and nomograms predicting whether a subject has BOO and needs prostatic surgery were validated with an external validation cohort from Seoul National University Bundang Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center between January 2004 and April 2015...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28446010/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-i-development-of-the-formula-and-its-internal-validation
#11
Min Soo Choo, Changwon Yoo, Sung Yong Cho, Seong Jin Jeong, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: As the elderly population increases, a growing number of patients have lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH). The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-making, and to validate them in patients with LUTS/BPH. METHODS: Patient with LUTS/BPH between October 2004 and May 2014 were enrolled as a development cohort...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28445807/rewiring-brain-circuits-to-block-cataplexy-in-murine-models-of-narcolepsy
#12
REVIEW
Meng Liu, Carlos Blanco-Centurion, Priyattam J Shiromani
Narcolepsy was first identified almost 130 years ago, but it was only 15 years ago that it was identified as a neurodegenerative disease linked to a loss of orexin neurons in the brain. It is unclear what causes the orexin neurons to die, but our strategy has been to place the gene for orexin into surrogate neurons in the validated mouse models of narcolepsy, and test whether it can block narcolepsy symptoms, such as cataplexy. In both the orexin knockout and the orexin-ataxin-3 mouse models of narcolepsy we have found that cataplexy can be blocked if the surrogate neurons are part of the circuit responsible for cataplexy...
April 23, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28445426/the-effects-of-magnesium-supplementation-on-subjective-anxiety-and-stress-a-systematic-review
#13
REVIEW
Neil Bernard Boyle, Clare Lawton, Louise Dye
BACKGROUND: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. METHODS: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28445359/the-impact-of-body-contouring-procedures-on-urologic-outcomes-in-massive-weight-loss-patients
#14
Oren P Mushin, Franca S Kraenzlin, Anees Fazili, Ahmed Ghazi, Ronald P Bossert
BACKGROUND: Post-massive weight loss body contouring is a growing area of plastic surgery. Studies have shown preexisting urinary incontinence amelioration in patients undergoing abdominal body-contouring procedures. These studies are small, focus on cosmetic abdominoplasties, and lack use of standardized surveys. The purpose of this study was to evaluate urinary incontinence endpoints in massive weight loss patients undergoing body-contouring procedures. METHODS: A retrospective review was conducted over a 6-year period...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445189/proton-pump-inhibitor-responsive-esophageal-eosinophilia-still-a-valid-diagnosis
#15
Javier Molina-Infante, Pedro L Gonzalez-Cordero, Alfredo J Lucendo
PURPOSE OF REVIEW: To update rapidly evolving concepts regarding the controversial entity of 'proton pump inhibitor (PPI)-responsive esophageal eosinophilia,' referring to patients with clinical, endoscopic and histologic features of eosinophilic esophagitis (EoE) who achieve remission on PPI therapy. RECENT FINDINGS: Up to half of pediatric and adult patients with typical EoE symptoms and histology achieve clinico-pathologic remission on PPI therapy, irrespective of whether esophageal pH monitoring demonstrates abnormal acid reflux...
April 25, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28445106/tension-free-inlay-repair-of-large-hiatal-hernias-using-dual-sided-composite-ptfe-eptfe-meshes-in-laparoscopic-surgery-for-gastroesophageal-reflux-disease
#16
Alexander M Prusa, Ivan Kristo, Erwin Rieder, Claudia Ringhofer, Reza Asari, Johannes Miholic, Sebastian F Schoppmann
BACKGROUND: Patients with gastroesophageal reflux disease (GERD) also frequently suffer from concomitant hiatal hernia. It has been described that a preoperative hiatal hernia of ≥3 cm is associated with a more than threefold relative risk for reflux symptom recurrence after fundoplication without mesh reinforcement. In this report, we describe our experience with the implantation of dual-sided composite PTFE/ePTFE meshes in a tension-free fashion during laparoscopic antireflux surgery (LARS)...
April 26, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28444906/carbamoyl-phosphate-synthetase-1-deficiency-diagnosed-by-whole-exome-sequencing
#17
Guoqing Zhang, Yulin Chen, Huiqun Ju, Fei Bei, Jing Li, Jian Wang, Jianhua Sun, Jun Bu
BACKGROUND: Carbamoyl Phosphate Synthetase 1 deficiency (CPS1D) is a rare autosomal recessive inborn metabolic disease characterized mainly by hyperammonemia. The fatal nature of CPS1D and its similar symptoms with other urea cycle disorders (UCDs) make its diagnosis difficult, and the molecular diagnosis is hindered due to the large size of the causative gene CPS1. Therefore, the objective of the present study was to investigate the clinical applicability of exome sequencing in molecular diagnosis of CPS1D in Chinese population...
April 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28444682/-transcultural-validation-in-spanish-of-the-actionable-bladder-symptoms-screening-tool
#18
T Munoz-Ruiz, V E Fernandez-Sanchez, V Reyes-Garrido, C Martinez-Tomas, P Urbaneja-Romero, A Gallardo-Tur, M Guerrero-Fernandez, A Leon-Martin, O Fernandez
INTRODUCTION: Disorders of the lower urinary tract are frequent in patients with multiple sclerosis throughout the course of the disease and reach variable prevalences close to 75%. It is essential to obtain an early diagnosis in the initial phases and to implement an optimal therapeutic management. Burks et al developed the Actionable Bladder Symptoms Screening Tool (ABSST) as a useful screening test in such disorders. Later, Bates et al developed a short version of the ABSST with the objective of minimising the time required to complete it and making it easier to use...
May 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28444406/-king-s-parkinson-s-disease-pain-scale-intercultural-adaptation-in-the-german-language
#19
REVIEW
W H Jost, A Rizos, P Odin, M Löhle, A Storch
BACKGROUND: Pain is a frequent symptom of idiopathic Parkinson's disease and has a substantial impact on quality of life. The King's Parkinson's disease pain scale (KPPS) has become internationally established and is an English-language, standardized, reliable and valid scale for evaluation of pain in idiopathic Parkinson's disease. This article presents a validated version in German. METHOD: The German translation was adapted interculturally and developed using an internationally recognized procedure in consultation with the authors of the original publication...
April 25, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28443168/an-iranian-version-of-the-fukushima-lumbar-spinal-stenosis-scale-fls-25-a-validation-study
#20
Parisa Azimi, Ali Montazeri
STUDY DESIGN: Cross-sectional study. PURPOSE: To translate and validate the Fukushima lumbar spinal stenosis (LSS) scale 25 (FLS-25) for use in Iran. OVERVIEW OF LITERATURE: Tools measuring patient-reported outcomes should satisfy certain psychometric properties. METHODS: FLS-25 is a self-administered scale for evaluating symptoms of LSS. A forward-backward procedure was applied to translate the questionnaire from English into Persian...
April 2017: Asian Spine Journal
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