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Prolactin receptor

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https://www.readbyqxmd.com/read/29778442/developmental-profiles-of-progesterone-receptor-transcripts-and-molecular-responses-to-gestagen-exposure-during-silurana-tropicalis-early-development
#1
Paisley Thomson, Valerie S Langlois
Environmental gestagens are an emerging class of contaminants that have been recently measured in surface water and can interfere with reproduction in aquatic vertebrates. Gestagens include endogenous progestogens, such as progesterone (P4), which bind P4-receptors and have critically important roles in vertebrate physiology and reproduction. Gestagens also include synthetic progestins, which are components of human and veterinary drugs, such as melengestrol acetate (MGA). Endogenous progestogens are essential in the regulation of reproduction in mammalian species, but the role of P4 in amphibian larval development remains unclear...
May 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29775019/-the-expression-and-clinical-progression-of-androgen-estrogen-and-prolactin-receptor-in-laryngeal-squamous-cell-carcinoma
#2
M J Fei, Y N Xu, J D Wang
Objective: The aim of this study is to analyze the different expression and function of androgen receptors (AR) and estrogen receptor (ER-α) in laryngeal squamous cell carcinoma (LSCC). In combination with the expression of prolactin receptor (PRLR), we analyzed the prognostic impact of three receptors on the laryngeal carcinoma. Method: In this study, immunohistochemistry and reverse transcription polymerase chain reaction (RT-PC) analysis were performed on the tumor tissues and adjacent normal tissues in 112 LSCC patients (95 males and 17 females)...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29767811/peripartum-cardiomyopathy
#3
T Koenig, D Hilfiker-Kleiner, J Bauersachs
Peripartum cardiomyopathy (PPCM) is a rare and potentially life-threatening disease that occurs toward the end of pregnancy or in the months following delivery in previously heart-healthy women. The incidence varies widely depending on geographical region and ethnic background, with an estimated number of 1 in 1000-1500 pregnancies in Germany. The course of the disease ranges from mild forms with minor symptoms to severe forms with acute heart failure and cardiogenic shock. The understanding of the etiology of PPCM has evolved in recent years...
May 16, 2018: Herz
https://www.readbyqxmd.com/read/29763375/chromosomal-architecture-and-placental-expression-of-the-human-growth-hormone-gene-family-are-targeted-by-pre-pregnancy-maternal-obesity
#4
Yan Jin, Hana Vakili, SongYan Liu, Savas Menticoglou, Margaret E Bock, Peter A Cattini
The human (h) placental lactogenic hormone chorionic somatomammotropin (CS) is highly produced during pregnancy and acts as a metabolic adaptor in response to maternal insulin resistance. Maternal obesity can exacerbate this "resistance" and a >75% decrease in CS RNA levels was observed in term placentas from obese versus lean women. The genes coding for hCS (hCS-A and hCS-B) and placental growth hormone (hGH-V) as well as the hCS-L pseudogene and pituitary growth hormone (GH) gene (hGH-N) are located at a single locus on chromosome 17...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29762665/mir-194-3p-represses-the-progesterone-receptor-and-decidualization-in-eutopic-endometrium-from-women-with-endometriosis
#5
Tianjiao Pei, Chang Liu, Tingting Liu, Li Xiao, Bin Luo, Jing Tan, Xueying Li, Guojun Zhou, Changling Duan, Wei Huang
Progesterone resistance in the eutopic endometrium (EuE) is suggested to be a critical factor for decreased endometrial receptivity and implantation failure in reproductive-aged women with endometriosis. Altered expression of miRNAs has been reported to play an important role in the pathophysiology of endometriosis-associated infertility. However, the underlying mechanisms of aberrant progesterone receptor (PR) and deficient decidualization regulated by miRNAs in endometriosis have not been thoroughly elucidated...
May 11, 2018: Endocrinology
https://www.readbyqxmd.com/read/29733861/effects-of-puerarin-on-estrogen-regulated-gene-expression-in-gonadotropin-releasing-hormone-pulse-generator-of-ovariectomized-rats
#6
Panida Loutchanwoot, Tina Vortherms
Effects of puerarin on the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator function is investigated, for the first time, in ovariectomized rats at the level of mRNA expression of estrogen-responsive genes, e.g., estrogen receptor (ER), GnRH and its receptor (GnRHR). Rats were treated orally for 90 days either with a soy-free diet containing two different doses of puerarin (low dose of 600 mg/kg and high dose of 3000 mg/kg) or estradiol benzoate (E2B) at either low dose (4.3 mg/kg) or high dose (17...
May 4, 2018: Steroids
https://www.readbyqxmd.com/read/29726995/the-balance-of-pi3k-and-erk-signaling-is-dysregulated-in-prolactinoma-and-modulated-by-dopamine
#7
Allyson K Roof, Siwanon Jirawatnotai, Tammy Trudeau, Crystal Kuzyk, Margaret E Wierman, Hiroaki Kiyokawa, Arthur Gutierrez-Hartmann
Prolactin-secreting adenomas, or prolactinomas, cause hypogonadism, osteoporosis, and infertility. Although dopamine agonists (DAs) are used clinically to treat prolactinoma, and reduce prolactin secretion via cAMP inhibition, the precise mechanism by which DAs inhibit lactotrope proliferation has not been defined. Here we report the novel finding that PI3K signals through AKT and mTOR to drive proliferation of pituitary somatolactotrope GH4T2 cells. We demonstrate that the DA cabergoline reduces activity of the mTOR effector s6K, and diminishes GH4T2 cell proliferation primarily via activation of the long isoform of the dopamine D2 receptor (D2R)...
May 2, 2018: Endocrinology
https://www.readbyqxmd.com/read/29720711/in-vitro-and-in-vivo-characterization-of-pcc0104005-a-novel-modulator-of-serotonin-dopamine-activity-as-an-atypical-antipsychotic-drug
#8
Yanan Xu, Xiaoyin Zhu, Hongbo Wang, Shanyue Sun, Xin Yue, Jingwei Tian
PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2 , D3 , D4 , serotonin 5-HT1A , and 5-HT2A receptors and antagonism at 5-HT2B , 5-HT6 , and 5-HT7 receptors. PCC0104005 blocks MK-801-induced hyperactivity in rats, consistent with the reduction in dopamine D2 receptor stimulation and increased dopamine release in the medial prefrontal cortex. PCC0104005 inhibits 5-HTP-induced head twitches in rats, due to its moderate affinity for human 5-HT2A receptors (Ki = 5...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29706934/isotocin-regulates-growth-hormone-but-not-prolactin-release-from-the-pituitary-of-ricefield-eels
#9
Wei Yang, Ning Zhang, Boyang Shi, Shen Zhang, Lihong Zhang, Weimin Zhang
The neurohypophyseal hormone oxytocin (Oxt) has been shown to stimulate prolactin (Prl) synthesis and release from the adenohypophysis in rats. However, little is known about the functional roles of Oxt-like neuropeptides in the adenohypophysis of non-mammalian vertebrates. In this study, cDNAs encoding ricefield eel oxytocin-like receptors (Oxtlr), namely isotocin (Ist) receptor 1 (Istr1) and 2 (Istr2), were isolated and specific antisera were generated, respectively. RT-PCR and Western blot analysis detected the presence of both Istr1 and Istr2 in the brain and pituitary, but differential expression in some peripheral tissues, including the liver and kidney, where only Istr1 was detected...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29684277/immunopet-imaging-of-endogenous-and-transfected-prolactin-receptor-tumor-xenografts
#10
Sarah M Cheal, Shutian Ruan, Darren R Veach, Valerie A Longo, Blesida J Punzalan, Jiong Wu, Edward K Fung, Marcus P Kelly, Jessica R Kirshner, Jason T Giurleo, George Ehrlich, Amy Q Han, Gavin Thurston, William C Olson, Pat B Zanzonico, Steven M Larson, Jorge A Carrasquillo
OBJECTIVE: Antibodies labeled with positron-emitting isotopes have been used for tumor detection, predicting which patients may respond to tumor antigen-directed therapy, and assessing pharmacodynamic effects of drug interventions. Prolactin receptor (PRLR) is overexpressed in breast and prostate cancers and is a new target for cancer therapy. We evaluated REGN2878, an anti-PRLR monoclonal antibody, as an immunoPET reagent. METHODS: REGN2878 was labeled with Zr-89 after conjugation with desferrioxamine B or labeled with I-131/I-124...
April 23, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29671937/quercetin-improves-postpartum-hypogalactia-in-milk-deficient-mice-via-stimulating-prolactin-production-in-pituitary-gland
#11
Man Lin, Na Wang, Bei Yao, Yao Zhong, Yan Lin, Tianhui You
Postpartum dysgalactia is a common clinical problem for lactating women. Seeking out the safe and efficient phytoestrogens will be a promising strategy for postpartum dysgalactia therapy. In this study, the postpartum mice within four groups, including control group, the model group, and the treatment groups intragastrically administrated with normal saline, bromocriptine, bromocriptine plus 17α-ethinyl estradiol, and bromocriptine plus quercetin, respectively, were used. The results showed that quercetin, a kind of natural phytoestrogen, could efficiently promote lactation yield and mammary gland development in the agalactosis mice produced by bromocriptine administration...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29665351/neuroendocrine-response-to-gaba-b-receptor-agonism-in-alcohol-dependent-individuals-results-from-a-combined-outpatient-and-human-laboratory-experiment
#12
Mehdi Farokhnia, Mikela B Sheskier, Mary R Lee, April N Le, Erick Singley, Sofia Bouhlal, Timmy Ton, Zhen Zhao, Lorenzo Leggio
Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the nervous system, plays an important role in biobehavioral processes that regulate alcohol seeking, food intake, and stress response. The metabotropic GABA-B receptor has been investigated as a potential therapeutic target for alcohol use disorder, by using orthosteric agonists (e.g., baclofen) and positive allosteric modulators. Whether and how pharmacological manipulation of the GABA-B receptor, in combination with alcohol intake, may affect feeding- and stress-related neuroendocrine pathways remains unknown...
April 14, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29658436/thrombin-alters-human-endometrial-stromal-cell-differentiation-during-decidualization
#13
Samir N Babayev, Mohammed Kanchwala, Chao Xing, Yucel Akgul, Bruce R Carr, Ruth Ann Word
Vaginal bleeding and subchorionic hematomas are associated with increased risk of both early and late pregnancy loss. Thrombin generation may play a pivotal role in the development of these complications. To determine the effects of thrombin on human endometrial stromal cells (hESCs), cells were treated with thrombin at baseline or during decidualization with cyclic adenosine monophosphate (cAMP)+medroxyprogesterone acetate (MPA). Next-generation RNA sequencing revealed that markers of decidualization (IGF-1, IGFBP-1, and prolactin [PRL]) were induced after the initiation of decidualization, whereas thrombin suppressed insulin-like growth factor ( IGF)-1, Insulin-like growth factor binding protein ( IGFBP)-1, and PRL gene expression at baseline and during decidualization...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29656222/prolactin-induced-protein-pip-is-a-potential-biomarker-for-early-stage-and-malignant-breast-cancer
#14
Anju Gangadharan, Themba Nyirenda, Kishan Patel, Nydia Jaimes-Delgadillo, Dominique Coletta, Takemi Tanaka, Ayal C Walland, Zena Jameel, Srinivasa Vedantam, Sittinon Tang, Ciaran Mannion, Grace Y Lee, Andre Goy, Andrew Pecora, K Stephen Suh
OBJECTIVES: Breast cancer (BC) is the second leading cause of cancer-related mortality in women. Bioinformatic analysis and expression screening showed that Prolactin Induced Protein (PIP) was differentially expressed in BC. The objective of this investigation was to characterize the expression pattern of PIP, an aspartyl proteinase, in malignant and non-malignant breast tissues. MATERIALS AND METHODS: Real time quantitative PCR was employed to analyze PIP and androgen receptor (AR) mRNA levels in BC cell lines and 190 normal tissues and tumor samples...
April 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29650790/effect-of-endocannabinoid-oleamide-on-rat-and-human-liver-cytochrome-p450-enzymes-in-in-vitro-and-in-vivo-models
#15
Gabriela Dovrtelova, Ondrej Zendulka, Kristyna Noskova, Jan Jurica, Ondrej Pes, Jan Dusek, Alejandro Carazo, Iveta Zapletalova, Natasa Hlavacova, Petr Pavek
The endocannabinoid system is important for many physiological and pathological processes, but its role in the regulation of liver cytochromes P450 (CYPs) is still unknown. We studied the influence of the endocannabinoid oleamide on rat and human liver CYPs. Oleamide was administered i.p. to rats at doses of 0.1, 1 and 10 mg/kg/day for 7 days. The content and activity of key CYPs was evaluated in rat liver microsomes. Moreover, its interactions with nuclear receptors regulating CYP genes and serum levels of their ligands (prolactin, corticosterone, and free triiodothyronine) were tested in vitro CYP inhibition assays...
April 12, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29622766/olfactory-marker-protein-regulates-prolactin-secretion-and-production-by-modulating-ca-2-and-trh-signaling-in-lactotrophs
#16
Chan Woo Kang, Ye Eon Han, Mi Kyung Lee, Yoon Hee Cho, NaNa Kang, JaeHyung Koo, Cheol Ryong Ku, Eun Jig Lee
Olfactory marker protein (OMP) is a marker of olfactory receptor-mediated chemoreception, even outside the olfactory system. Here, we report that OMP expression in the pituitary gland plays a role in basal and thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) production and secretion. We found that OMP was expressed in human and rodent pituitary glands, especially in PRL-secreting lactotrophs. OMP knockdown in GH4 rat pituitary cells increased PRL production and secretion via extracellular signal-regulated kinase (ERK)1/2 signaling...
April 6, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29622663/16kda-vasoinhibin-binds-to-integrin-alpha5-beta1-on-endothelial-cells-to-induce-apoptosis
#17
Kazunori Morohoshi, Ryo Mochinaga, Tsukasa Watanabe, Ryojun Nakajima, Toshio Harigaya
Many functions of vasoinhibins have been reported, but its receptor has not been clarified yet. Vasoinhibins, 11-18kDa N-terminal fragments of prolactin, have anti-angiogenic activity and act on endothelial cells to induce apoptosis and to inhibit migration and proliferation, which are opposite to the effects of prolactin. Although vasoinhibins bind to the prolactin-receptor, its binding activity is very weak compared to prolactin. Therefore, in this study, we evaluated the binding activity between 16kDa vasoinhibin and Integrin beta1, alpha5 beta1, alpha1 beta1 and alphaV beta3 to identify a specific receptor for vasoinhibins...
April 5, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29615476/neuronostatin-exerts-actions-on-pituitary-that-are-unique-from-its-sibling-peptide-somatostatin
#18
Raul M Luque, Rhonda D Kineman
Neuronostatin, a somatostatin gene-encoded peptide, exerts important physiological and metabolic actions in diverse tissues. However, the direct biological effects of neuronostatin on pituitary function of humans and primates are still unknown. This study used baboon (Papio anubis) primary pituitary cell cultures, a species that closely models human physiology, to demonstrate that neuronostatin inhibits basal, but not ghrelin-/GnRH-stimulated, GH and LH secretion in a dose- and time-dependent fashion, without affecting the secretion of other pituitary hormones (prolactin, ACTH, FSH, TSH) or changing mRNA levels...
April 3, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29602470/the-possible-role-of-stress-induced-hormonal-disbalance-in-the-patophysiology-of-insulin-resistane-in-lean-individuals
#19
K Blaslov, I Kruljac, G Mirošević, Lora S Kirigin Biloš, M Vrkljan
Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore, the mechanism of its development is in the center of scientific and professional interest. Established or acquired factors, or combinations thereof, which disturb any step of the physiological insulin action mechanism: its binding to the cellular receptor, through the complex cascade of intracellular signaling pathways might cause IR...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29601847/repeated-peripheral-administration-of-lipidized-prolactin-releasing-peptide-analog-induces-c-fos-and-fosb-expression-in-neurons-of-dorsomedial-hypothalamic-nucleus-in-male-c57-mice
#20
Zdenko Pirník, Mária Kolesárová, Blanka Železná, Lenka Maletínská
Previous studies indicate that hypothalamic prolactin-releasing peptide (PrRP), signaling via GPR10 and neuropeptide FF2 receptor, is involved in energy homeostasis, stress responses, and cardiovascular regulation. Energy homeostasis depends on the balance between food intake regulation and energy expenditure, in which the hypothalamus plays a key role. The lipidization of PrRP31 with palmitoyl acid allows it to produce its anorexigenic effect after repeated peripheral administration and to reduce body weight and improve metabolic parameters in diet-induced obese (DIO) mice...
March 27, 2018: Neurochemistry International
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