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Intraductal pancreatic mucous neoplasm

Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
April 16, 2018: Histochemistry and Cell Biology
Yuko Kinowaki, Yutaka Takazawa, Noriko Yamamoto, Yuichi Ishikawa
Intraductal papillary mucinous neoplasms (IPMN) are characterized by the growth of epithelial components with mucin production in the main pancreatic duct, or a large branch. We report a case of intraductal papillary mucinous carcinoma (IPMC) of the pancreatic head, complicated by pancreaticobiliary maljunction (PBM) and an aberrant pancreatic duct draining into the stomach. A 50-year-old man with malaise and jaundice was found to have a mass in the pancreatic head at a local hospital. He was clinically diagnosed with IPMC with invasion to the stomach and duodenum after extensive endoscopic and radiological evaluation and a pancreaticoduodenectomy was performed...
February 2016: Pathology, Research and Practice
Mikiko Kobayashi, Yasunari Fujinaga, Hiroyoshi Ota
Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing neoplasms of the main and/or branch pancreatic ducts. To assess differences between various IPMN subtypes, immunohistochemical markers of gastric surface mucous cells (MUC5AC), gastric gland mucous cells (MUC6 and GlcNAcα1→4Galβ→R), gastric pyloric and duodenal epithelial cells (PDX1), intestinal cells (MUC2 and CDX2), small intestinal cells (CPS1) and large intestinal cells (SATB2) were evaluated in 33 surgically treated IPMNs...
May 1, 2014: Acta Histochemica et Cytochemica
Yasunobu Yamashita, Kazuki Ueda, Masahiro Itonaga, Takeichi Yoshida, Hiroki Maeda, Takao Maekita, Mikitaka Iguchi, Hideyuki Tamai, Masao Ichinose, Jun Kato
OBJECTIVES: The aim of this study was to evaluate the ability of contrast-enhanced endoscopic sonography for discrimination of mural nodules from mucous clots in intraductal papillary mucinous neoplasms of the pancreas. METHODS: Contrast-enhanced endoscopic sonography was performed in 17 consecutive patients who had an intraductal papillary mucinous neoplasm with mural lesions. To perform contrast-enhanced endoscopic sonography, we used a second-generation sonographic contrast agent...
January 2013: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Naoshi Tajima, Kenichi Utano, Shigeyoshi Kijima, Akira Kawai, Akifumi Fujita, Kazuya Sakuma, Hideharu Sugimoto, Hirofumi Fujii
A 65-year-old man was referred to our hospital due to epigastric pain. Abdominal enhanced computed tomography (CT) demonstrated marked dilatation of the main pancreatic duct (MPD) and communication to the gastric and duodenal lumen was suspected. Esophagogastroduodenoscopy (EGD) showed a villous tumor with white mucous discharge in the posterior wall of the gastric corpus and duodenal bulb. Pathological specimens showed mucin-producing epithelium with nuclear atypia that had developed in a papillary form. Based on these findings, we diagnosed intraductal papillary mucinous neoplasm (IPMN) arising in the MPD with penetration into the gastric and duodenal lumen...
July 2013: Journal of Magnetic Resonance Imaging: JMRI
Masayuki Kitano, Hiroki Sakamoto, Takamitsu Komaki, Masatoshi Kudo
Although endoscopic ultrasonography (EUS) has the advantage over other imaging methods in that it is possible to obtain high resolution images of the pancreas, it is limited in its ability to characterize pancreatic masses. Contrast-enhanced power Doppler ultrasonography suffers from several limitations such as blooming artifacts, poor spatial resolution, low sensitivity to slow flow and high sensitivity to motion artifacts. Recently, EUS system specific for contrast harmonic imaging has been developed. The use of this EUS system enabled us to observe images of microcirculation and parenchymal perfusion without Doppler-related artifacts in the pancreas...
May 2011: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Masakazu Nakano, Keiichi Tominaga, Hidetaka Watanabe, Kazunari Kanke, Masaya Tamano, Hideyuki Hiraishi
An 83-year old Japanese man was transferred to our hospital due to a 1-week history of melena and signs of disordered awareness. Esophagogastroduodenoscopy showed a villous tumor associated with massive white mucous discharge in the posterior wall of the gastric corpus, where pathologically identified mucin-producing epithelium with nuclear atypia had developed into a papillary form. An abdominal enhanced computed tomography scan demonstrated communication between the dilated main pancreatic duct and the gastric lumen...
January 2010: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Toshio Nakagohri, Taira Kinoshita, Masaru Konishi, Shinichiro Takahashi, Naoto Gotohda, Shin Kobayashi, Motohiro Kojima, Hideaki Miyauchi, Takehide Asano
BACKGROUND: Previous reports have suggested that patients with intraductal papillary mucinous neoplasm (IPMN) have a favorable prognosis after surgical resection. Thus, a variety of types of partial pancreatic resections have been advocated for treating these low-grade malignant tumors. However, the surgical outcome of IPMN after such limited pancreatectomy has not been fully clarified. METHODS: We performed a retrospective review of the clinicopathologic features and surgical outcome in 15 patients who underwent inferior head resection for IPMN at the Chiba University Hospital and National Cancer Center Hospital East between July 1994 and January 2007...
November 2010: Journal of Hepato-biliary-pancreatic Sciences
Ling Tan, Ya-E Zhao, Deng-Bin Wang, Qing-Bing Wang, Jing Hu, Ke-Min Chen, Xia-Xing Deng
AIM: To retrospectively evaluate the imaging features of pancreatic intraductal papillary mucinous neoplasms (IPMNs) in multi-detector row computed tomography (MDCT). METHODS: A total of 20 patients with pathologically-confirmed intraductal papillary mucinous neoplasms (IPMNs) were included in this study. Axial MDCT images combined with CT angiography (CTA) and multiplanar volume reformations (MPVR) or curved reformations (CR) were preoperatively acquired. Two radiologists (Tan L and Wang DB) reviewed all the images in consensus using an interactive picture archiving and communication system...
August 28, 2009: World Journal of Gastroenterology: WJG
Eizaburo Ohno, Yoshiki Hirooka, Akihiro Itoh, Masatoshi Ishigami, Yoshiaki Katano, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto
BACKGROUND AND AIM: Intraductal papillary mucinous neoplasms (IPMNs)have a wide pathologic spectrum and it is difficult to differentiate malignant from benign tumors. The aim of this study was to identify predictors of malignancy using contrast-enhanced endoscopic ultrasound (CE-EUS). SUBJECTS AND METHODS: In our institute, main duct type and mixed type IPMNs, branch duct type IPMNs with mural nodules, and IPMNs with coexistent invasive ductal cancer were indications for surgery...
April 2009: Annals of Surgery
Shinichi Ban, Yoshihisa Naitoh, Mari Mino-Kenudson, Takaki Sakurai, Makoto Kuroda, Isamu Koyama, Gregory Y Lauwers, Michio Shimizu
Intraductal papillary mucinous neoplasm (IPMN) is a unique pancreatic neoplasm developing in the ductal system. Two major histologic subtypes have been reported, that is the gastric type and the intestinal type. However, their histopathologic features, especially those of the gastric type, have not been fully described. To evaluate the features of these two types and refine their differences, we analyzed 80 IPMNs including 50 cases of the gastric type and 30 cases of the intestinal type with mucin immunohistochemistry...
December 2006: American Journal of Surgical Pathology
(no author information available yet)
280 epithelial tumors of the pancreas including 72 exocrine tumors (50 adenocarcinomas, 10 mucin-cystic, 6 intraductal, 6 serous cystic), 202 endocrine tumors and 6 undifferentiated neoplasms and surrounding parenchyma outside of the tumors were studied. Tumors arise against the background of pronounced proliferation of polypotent cells of the ducts. In case of tumors of ductal origin hyperplasia of ductal epithelium and acinar- ductal transformation of surrounding parenchyma are observed while in tumors with neuroendocrine differentiation there is mucous-papillary hyperplasia of ductal epithelium with proliferation in them of endocrine precursors, less frequently- acinar-endocrine transformation of surrounding parenchyma...
March 2006: Arkhiv Patologii
Terumi Kamisawa, Yuyang Tu, Naoto Egawa, Hitoshi Nakajima, Kouji Tsuruta, Atsutake Okamoto
AIM: As intraductal papillary mucinous neoplasm (IPMN) has a favorable prognosis, associated malignancies have potential significance in these patients. We examined the incidence and characteristics of pre-existing, coexisting and subsequent malignancies in patients with IPMN. METHODS: Seventy-nine cases of IPMN were diagnosed by detection of mucous in the pancreatic duct during endoscopic retrograde pancreatography. Histological diagnosis was confirmed in 30 cases (adenoma (n = 19) and adenocarcinoma (n = 11)...
September 28, 2005: World Journal of Gastroenterology: WJG
Takuma Tajiri, Genshu Tate, Toshiaki Kunimura, Kazuaki Inoue, Toshiyuki Mitsuya, Makoto Yoshiba, Toshio Morohosh
OBJECTIVE: To analyze the differences between intraductal tubular carcinoma (ITC) and intraductal papillary-mucinous carcinoma (IPMC), we performed light microscopic and immunohistochemical analysis of 4 cases of ITC, 6 cases of IPMC, and 9 cases of ductal adenocarcinoma of the pancreas. METHODS AND RESULTS: Light microscopic examination showed no hyperplasia or adenoma around the carcinoma in ITC, and immunohistochemical analysis showed that the apical side of the cell membrane was positive for MUC-1 in almost all ITC cells...
August 2004: Pancreas
Jorge Albores-Saavedra, Deepti Shukla, Kelley Carrick, Donald E Henson
We report 49 cases of gallbladder carcinomas that extended into or originated from Rokitansky-Aschoff sinuses (RAS), all of which were resected by laparoscopic cholecystectomy. Twenty-one tumors were in situ carcinomas that extended along RAS; six in situ carcinomas arose in adenomyomatous hyperplasia and 22 were invasive adenocarcinomas with extension into RAS. Thirty-seven patients were women and 12 men. Forty patients had cholelithiasis. The age of the patients ranged from 55 to 84 years (mean 67 years)...
May 2004: American Journal of Surgical Pathology
Yutaka Suzuki, Yutaka Atomi, Masanori Sugiyama, Shuji Isaji, Kazuo Inui, Wataru Kimura, Makoto Sunamura, Toru Furukawa, Akio Yanagisawa, Jo Ariyama, Tadahiro Takada, Hidenobu Watanabe, Koichi Suda et al.
The Japan Pancreas Society performed a multiinstitutional, retrospective study of 1379 cases of intraductal papillary mucinous tumor (IPMT) and 179 cases of mucinous cystic tumor (MCT) of the pancreas. Clinicopathologic features and postoperative long-term outcomes were investigated. IPMT were most frequently found in men and in the head of the pancreas. In contrast, all patients with MCT were women. Ovarian-type stroma were found in only 42.2% of the MCT cases. Prognostic indicators of malignant IPMT included advanced age, positive symptoms, abundant mucous secretion, presence of large nodules and/or large cysts, remarkable dilatation of the main pancreatic duct, and main duct- or combined-type IPMT...
April 2004: Pancreas
Hirozumi Sawai, Yuji Okada, Moritsugu Tanaka, Hitoshi Funahashi, Tetsushi Hayakawa, Tadao Manabe
INTRODUCTION AND AIMS: Intraductal papillary-mucinous tumors (IPMTs) of the pancreas are intraductal tumors with diffuse or segmental dilation of the pancreatic ducts and intraductal papillary growth with abundant mucous secretion. We examined clinicopathological features and immunohistochemical findings to investigate the malignancy of IPMTs. METHODOLOGY: Between April 1994 and December 2002, 23 patients with IPMT underwent pancreatic resections at Nagoya City University Hospital, Japan...
January 2004: Pancreas
Kenji Yamao, Kazuhiko Ohashi, Tsuneya Nakamura, Takashi Suzuki, Akira Sawaki, Kazuo Hara, Akira Fukutomi, Toshiaki Baba, Kenji Okubo, Kyosuke Tanaka, Ichiro Moriyama, Kosuke Fukuda, Kakuya Matsumoto, Yasuhiro Shimizu
BACKGROUND: The aim of this study was to evaluate the usefulness of peroral pancreatoscopy in the diagnosis of pancreatic diseases. METHODS: Both 3.7-mm (thin) and 0.8-mm (ultra-thin) diameter fiberoptic pancreatoscopes were used in 115 cases (pancreatic cancer, 35; benign ductal stenosis, 20; intraductal papillary-mucinous tumor, 60). RESULTS: Observation rates for pancreatic cancer, benign ductal stenosis, and intraductal papillary-mucinous tumor were, respectively, 63%, 80%, and 95%...
February 2003: Gastrointestinal Endoscopy
F Maire, P Hammel, B Terris, S Olschwang, D O'Toole, A Sauvanet, L Palazzo, P Ponsot, B Laplane, P Lévy, P Ruszniewski
Familial adenomatous polyposis (FAP) is characterised by the development of numerous colorectal adenomatous polyps. Other extracolonic benign or malignant lesions have been reported previously in association with FAP but precancerous lesions in the pancreas have never been described. We report the first case of intraductal papillary and mucinous pancreatic tumour (IPMT) in a patient with FAP. A 48 year old man with a well documented past history of FAP was admitted for epigastric pain, weight loss, and new onset diabetes mellitus...
September 2002: Gut
Takamichi Komori, Osamu Ishikawa, Hiroaki Ohigashi, Terumasa Yamada, Yo Sasaki, Shingi Imaoka, Akihiko Nakaizumi, Hiroyuki Uehara, Sachiko Tanaka, Yoshiyuki Mano, Tsutomu Kasugai
Recently, there have been a few case reports of invasive ductal adenocarcinoma (IDC) developed in the remnant pancreas after partial pancreatectomy for intraductal papillary-mucinous neoplasm (IPMN). It is necessary to clarify their histogenetic relationships among two sporadic tumors and their surrounding duct epithelium and it would be more reliable if genetic analysis is added to the conventional histology. We report a 76-year-old woman who received pancreaticoduodenectomy for IPMN with a focal in situ carcinoma (IPMC), which was transitional to the surrounding duct epithelium with papillary proliferation and a wide variety of dysplasia...
April 2002: Japanese Journal of Clinical Oncology
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