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https://www.readbyqxmd.com/read/28331174/development-of-customized-18-f-fluoride-elution-techniques-for-the-enhancement-of-copper-mediated-late-stage-radiofluorination
#1
Andrew V Mossine, Allen F Brooks, Naoko Ichiishi, Katarina J Makaravage, Melanie S Sanford, Peter J H Scott
In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to radiopharmaceuticals that were challenging to synthesize using traditional fluorine-18 radiochemistry. However, the process of adapting these new reactions for automated radiopharmaceutical production has revealed limitations in fitting them into the confines of traditional radiochemistry systems...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28315908/positive-99m-tc-mibi-and-the-subtraction-parathyroid-scan-are-related-to-intact-parathyroid-hormone-but-not-to-total-plasma-calcium-in-primary-hyperparathyroidism
#2
Sanja Dugonjić, Marija Šišić, Marija Radulović, Boris Ajdinović
OBJECTIVE: Primary hyperparathyroidism (pHPT) is characterised by increased parathyroid hormone (PTH) secretion and consequently increased plasma calcium. During the last few decades parathyroid scintigraphy (PS), is applied in almost all patients with pPHT before surgery and specifically before minimally invasive parathyroidectomy. The aim of this study was to find the best cut-off levels of total plasma calcium and intact PTH (iPTH) that correlate with positive technetium-99m-methoxy isobutyl isonitrile ((99m)Tc-MIBI) PS and with positive subtraction PS (SPS) in patients with pHPT and thus the positive diagnostic value of these PS...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28303300/consequences-of-radiopharmaceutical-extravasation-and-therapeutic-interventions-a-systematic-review
#3
REVIEW
Jochem van der Pol, Stefan Vöö, Jan Bucerius, Felix M Mottaghy
PURPOSE: Radiopharmaceutical extravasation can potentially lead to severe soft tissue damage, but little is known about incidence, medical consequences, possible interventions, and effectiveness of these. The aims of this study are to estimate the incidence of extravasation of diagnostic and therapeutic radiopharmaceuticals, to evaluate medical consequences, and to evaluate medical treatment applied subsequently to those incidents. METHODS: A sensitive and elaborate literature search was performed in Embase and PubMed using the keywords "misadministration", "extravasation", "paravascular infiltration", combined with "tracer", "radionuclide", "radiopharmaceutical", and a list of keywords referring to clinically used tracers (i...
March 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28302035/translational-multimodality-neuroimaging
#4
Sushil K Sharma
Recently high-resolution, noninvasive, multimodality in-vivo molecular imaging with PET, SPECT, CT and MRI, employing fusion algorithms has revolutionized personalized medicine. However, specific radiopharmaceuticals (RPs) for the accurate diagnosis and effective treatment of progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, drug addiction, and other cognitive impairments still remain in developmental phase. Currently, multimodality fusion neuroimaging is utilized for the determination of: pharmacokinetics and pre-clinical development of radiopharmaceuticals (RPs); in-vivo monitoring of stem cell transplantation therapy; nicotinic acetylcholine receptors (nAChRs) investigations; and regional cerebral blood flow and glucose metabolism in cognitively-impaired subjects employing noninvasive microPET and nano-SPECT imaging...
March 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28301260/cancer-targeting-potential-of-99m-tc-finasteride-in-experimental-model-of-prostate-carcinogenesis
#5
Gowsia Jan, Neelima D Passi, Devinder Kumar Dhawan, Vijayta Dani Chadha
This study aimed to radiolabel finasteride, a novel 5α-reductase inhibitor, to evaluate its cancer targeting potential in experimental model of prostate carcinogenesis. Finasteride was effectively radiolabeled with (99m)Tc and showed >90% labeling efficiency. The radiopharmaceutical was found to be stable up to 6 hours in rat serum at 37°C. The blood kinetics of the (99m)Tc-finasteride followed a biphasic release pattern, whereby fast-release phase was observed at 15 seconds and a slow-release phase was observed after 30 minutes of administration...
March 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28300723/nuclear-medicine-for-photodynamic-therapy-in-cancer-planning-monitoring-and-nuclear-pdt
#6
REVIEW
Dris Kharroubi Lakouas, Damien Huglo, Serge Mordon, Maximilien Vermandel
Photodynamic therapy (PDT) is a modality with promising results for the treatment of various cancers. PDT is increasingly included in the standard of care for different pathologies. This therapy relies on the effects of light delivered to photosensitized cells. At different stages of delivery, PDT requires imaging to plan, evaluate and monitor treatment. The contribution of molecular imaging in this context is important and continues to increase. In this article, we review the contribution of nuclear medicine imaging in oncology to PDT for planning and therapeutic monitoring purposes...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28297310/production-and-quality-control-177-lu-nca-dotmp-as-a-potential-agent-for-bone-pain-palliation
#7
Nafise Salek, Mojtaba Shamsaei, Mohammad Ghannadi Maragheh, Simindokht Shirvani Arani, Ali Bahrami Samani
Skeletal uptake of radiolabeled-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetramethylene phosphoric acid (e.g., (177) Lu-DOTMP) complex, is used for bone pain palliation. The moderate energy of β-emitting 177Lu (T1/2=6.7 d,Eβmax=497 keV) has been considered as a potential radionuclide for development of the bone-seeking radiopharmaceutical. Since the specific activity of the radiolabeled carrier molecules should be high, the "no-carrier-added radionuclides" have significant roles in nuclear medicine...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295000/current-status-of-radiopharmaceuticals-for-the-theranostics-of-neuroendocrine-neoplasms
#8
REVIEW
Melpomeni Fani, Petra Kolenc Peitl, Irina Velikyan
Nuclear medicine plays a pivotal role in the management of patients affected by neuroendocrine neoplasms (NENs). Radiolabeled somatostatin receptor analogs are by far the most advanced radiopharmaceuticals for diagnosis and therapy (radiotheranostics) of NENs. Their clinical success emerged receptor-targeted radiolabeled peptides as an important class of radiopharmaceuticals and it paved the way for the investigation of other radioligand-receptor systems. Besides the somatostatin receptors (sstr), other receptors have also been linked to NENs and quite a number of potential radiolabeled peptides have been derived from them...
March 15, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28285355/technetium-99m-labeled-sulfadiazine-a-targeting-radiopharmaceutical-for-scintigraphic-imaging-of-infectious-foci-due-to-escherichia-coli-in-mouse-and-rabbit-models
#9
Muhammad Tauqeer Ahmed, Syed Ali Raza Naqvi, Rashid Rasheed, Ameer Fawad Zahoor, Muhammad Usman, Zaib Hussain
Bacterial infection is one of the vital reasons of morbidity and mortality, especially in developing countries. It appears silently without bothering the geological borders and imposes a grave threat to humanity. Nuclear medicine technique has an important role in helping early diagnosis of deep-seated infections. The aim of this study was to develop a new radiopharmaceutical (99m)Tc-labeling sulfadiazine as an infection imaging agent. Radiolabeling of sulfadiazine with technetium-99m ((99m)Tc) was carried out using stannous tartrate as a reducing agent in the presence of gentistic acid at pH = 5...
March 11, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28279906/preparation-and-evaluation-of-rhenium-188-pamidronate-as-a-palliative-treatment-in-bone-metastasis
#10
Mostafa Erfani, Nasim Rahmani, Alireza Doroudi, Mohammad Shafiei
OBJECTIVE: Rhenium-188-hydroxyethylidene diphosphonate ((188)Re-HEDP) as a first generation bisphosphonate has been widely used for bone seeking radiopharmaceutical in cases of metastatic bone disease. No study has been yet reported on preparing a complex of (188)Re with pamidronate (3-aminohydroxypropylidene-1,1-bisphosphonic acid) (PMA) as a second generation bisphosphonate. Based on this fact, it was hypothesized that a bone-seeking (188)Re-PMA radiopharmaceutical could be developed as an agent for palliative radiotherapy of bone pain due to skeletal metastases...
February 24, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28274619/pet-mri-of-the-thorax-abdomen-and-retroperitoneum-benefits-of-the-breathing-synchronized-scanning
#11
Jan Baxa, Eva Ferdova, Jiří Ferda
Hybrid imaging using various radiopharmaceuticals is currently essential not only in detection and therapy response monitoring of tumors, but also in assessment of inflammatory or systemic diseases. Combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) is still relatively new method with great prospects of comprehensive assessment using anatomical and multiple functional information. However, benefits of PET/MRI in thorax, abdomen and retroperitoneum are not completely defined...
February 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28273495/-99m-tc-labeling-and-evaluation-of-a-hynic-modified-small-molecular-inhibitor-of-prostate-specific-membrane-antigen
#12
Xiaoping Xu, Jianping Zhang, Silong Hu, Simin He, Xiao Bao, Guang Ma, Jianmin Luo, Jingyi Cheng, Yingjian Zhang
INTRODUCTION: Prostate-specific membrane antigen (PSMA) is a well-established target in the development of radiopharmaceuticals for the diagnosis and therapy of prostate cancer (PCa). In this study, we evaluated a novel (99m)Tc-labeled small molecular inhibitor of PSMA. METHODS: This new small-molecular inhibitor of PSMA, 6-hydrazinonicotinate-Aminocaproic acid-Lysine-Urea-Glutamate (HYNIC-ALUG) was radiolabeled by (99m)Tc and was evaluated both in vitro and in vivo using PCa models (PC-3 and LNCaP)...
January 28, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28268918/forward-backward-pursuit-algorithm-for-cerenkov-luminescence-tomography
#13
Haixiao Liu, Zhenhua Hu, Muhan Liu, Jie Tian
Cerenkov luminescence tomography (CLT) is a powerful imaging technique that allows dynamically and three-dimensionally resolving the metabolic process of radiopharmaceuticals. It uses optical method to detect radiopharmaceuticals with low cost and high sensitivity. However, because of the strong absorption and scatter of biological tissues, the reconstruction of CLT is always converted to an ill-posed linear system which is hard to solve. An accurate and fast reconstruct algorithm becomes a current issue. The traditional reconstruction algorithm based on l2 norm regularization is too smooth and with low accuracy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267450/imaging-of-prostate-cancer-using-gallium-68-labeled-bombesin
#14
REVIEW
Ida Sonni, Lucia Baratto, Andrei Iagaru
Nuclear medicine can play an important role in evaluating prostate cancer combining anatomical and functional information with hybrid techniques. Various PET radiopharmaceuticals have been used for targeting specific biological markers in prostate cancer. Research is ideally oriented towards the development of radiopharmaceuticals targeting antigens overexpressed in prostate cancer, as opposed to normal prostate tissue. In this regard, gastrin-releasing peptide receptors (GRPR) are excellent candidates. Bombesin analogues targeting the GRPR have been investigated...
April 2017: PET Clinics
https://www.readbyqxmd.com/read/28266269/liposomal-nanotechnology-for-cancer-theranostics
#15
Zhifei Dai, Xiuli Yue
Liposomes are a type of biomimetic nanoparticles generated from self-assembling concentric lipid bilayer enclosing an aqueous core domain. They have been attractive nanocarriers for the delivery of many drugs (e.g. radiopharmaceuticals, chemotherapeutic agents, porphyrin) and diagnostic agents (e.g. fluorescent dyes, quantum dots, Gadolinium complex and Fe3O4) by encapsulating (or adsorbing) hydrophilic one inside the liposomal aqueous core domain (or on the bilayer membrane surface), and by entrapping hydrophobic one within the liposomal bilayer...
March 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28263213/abnormal-18-f-fdg-and-82-rb-pet-findings-in-chagas-heart-disease
#16
Medhi S Salimy, Purvi J Parwani, Kanae Mukai, Miguel Hernandez Pampaloni, Robert R Flavell
Uptake of the radiopharmaceutical F-FDG visualized by PET imaging can reflect abnormal myocardial inflammation. When utilized in conjunction with other imaging modalities, such as echocardiography, PET F-FDG imaging can help distinguish between active cardiac sarcoidosis and other etiologies of nonischemic cardiomyopathy. We present a case of a 46-year-old man with nonischemic cardiomyopathy and ventricular tachycardia who underwent an echocardiogram suggestive of cardiac Chagas disease. A subsequent F-FDG PET demonstrated abnormal hypermetabolism...
March 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28263212/a-phase-1-trial-of-cabazitaxel-combined-with-188-re-hydroxyethylidene-diphosphonate-in-patients-with-metastatic-castration-resistant-prostate-cancer-who-progressed-on-or-after-a-docetaxel-containing-treatment-the-recab-trial
#17
Joyce M van Dodewaard-de Jong, Esther W Bouman-Wammes, Haiko J Bloemendal, Henk M W Verheul, John M H de Klerk, Alfons J M van den Eertwegh
PURPOSE: In patients with metastatic castration-resistant prostate cancer (mCRPC), bone-seeking radiopharmaceuticals, such as Re-hydroxyethylidene diphosphonate (HEDP), are effective for pain palliation and have a marked antitumor effect. Cabazitaxel is the standard second-line chemotherapy for mCRPC patients. We performed a phase 1 study investigating the safety and feasibility of the combined treatment with Re-HEDP and cabazitaxel in mCRPC patients. METHODS: Patients with mCRPC and documented disease progression on or after docetaxel were eligible for inclusion...
March 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28254866/proof-of-therapeutic-efficacy-of-a-novel-177-lu-labeled-neurotensin-receptor-1-antagonist-in-a-colon-carcinoma-xenograft-model
#18
Jörg Schulz, Martin Rohracker, Marvin Stiebler, Jürgen Goldschmidt, Franziska Stöber, Mercedes Noriega, Anette Pethe, Mathias Lukas, Frank Osterkamp, Ulrich Reineke, Aileen Höhne, Christiane Smerling, Holger Amthauer
Purpose: Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number of tumor entities like pancreatic or colon carcinoma. Hence, this receptor is a promising target for diagnostic imaging and radioligand therapy (RLT). Based on favorable biodistribution data of the NTR1-targeting agent (111)In-3BP 227, we investigated the therapeutic effect of its (177)Lu-labeled analog on the tumor growth of NTR1-positive HT29 colon carcinoma xenografts. Methods: 3BP 227 was labeled with (177)Lu...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28237004/nuclear-medicine-in-pediatric-cardiology
#19
REVIEW
Ornella Milanesi, Giovanni Stellin, Pietro Zucchetta
Accurate cardiovascular imaging is essential for the successful management of patients with congenital heart disease (CHD). Echocardiography and angiography have been for long time the most important imaging modalities in pediatric cardiology, but nuclear medicine has contributed in many situations to the comprehension of physiological consequences of CHD, quantifying pulmonary blood flow symmetry or right-to-left shunting. In recent times, remarkable improvements in imaging equipments, particularly in multidetector computed tomography and magnetic resonance imaging, have led to the progressive integration of high resolution modalities in the clinical workup of children affected by CHD, reducing the role of diagnostic angiography...
March 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28237000/dose-estimation-in-pediatric-nuclear-medicine
#20
REVIEW
Frederic H Fahey, Alison B Goodkind, Donika Plyku, Kitiwat Khamwan, Shannon E O'Reilly, Xinhua Cao, Eric C Frey, Ye Li, Wesley E Bolch, George Sgouros, S Ted Treves
The practice of nuclear medicine in children is well established for imaging practically all physiologic systems but particularly in the fields of oncology, neurology, urology, and orthopedics. Pediatric nuclear medicine yields images of physiologic and molecular processes that can provide essential diagnostic information to the clinician. However, nuclear medicine involves the administration of radiopharmaceuticals that expose the patient to ionizing radiation and children are thought to be at a higher risk for adverse effects from radiation exposure than adults...
March 2017: Seminars in Nuclear Medicine
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