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https://www.readbyqxmd.com/read/29238922/rational-evaluation-of-the-therapeutic-effect-and-dosimetry-of-auger-electrons-for-radionuclide-therapy-in-a-cell-culture-model
#1
Ayaka Shinohara, Hirofumi Hanaoka, Tetsuya Sakashita, Tatsuhiko Sato, Aiko Yamaguchi, Noriko S Ishioka, Yoshito Tsushima
OBJECTIVE: Radionuclide therapy with low-energy auger electron emitters may provide high antitumor efficacy while keeping the toxicity to normal organs low. Here we evaluated the usefulness of an auger electron emitter and compared it with that of a beta emitter for tumor treatment in in vitro models and conducted a dosimetry simulation using radioiodine-labeled metaiodobenzylguanidine (MIBG) as a model compound. METHODS: We evaluated the cellular uptake of 125I-MIBG and the therapeutic effects of 125I- and 131I-MIBG in 2D and 3D PC-12 cell culture models...
December 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29237238/directional-probe-for-radio-guided-surgery-a-pilot-study
#2
Roberto Massari, Antonio Ucci, Annunziata D'Elia, Costantino Campisi, Emilio Bertani, Alessandro Soluri
The sentinel lymph node (SLN) biopsy technique has highly evolved during the last twenty years. Consequently, the intraoperative use of Gamma Probes (GPs) for SLN mapping is increased. This preliminary study evaluates a novel directional GP prototype. This proof-of-concept prototype is designed to identify the direction of radiopharmaceuticals uptakes, by combining the information from multiple detectors. The purpose of this work is to develop a tool able to effectively guide the surgeon reducing the surgery time...
December 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29233263/discovery-of-pet-radiopharmaceuticals-at-the-academia-industry-interface
#3
REVIEW
Vadim Bernard-Gauthier, Thomas L Collier, Steven H Liang, Neil Vasdev
Project-specific collaborations between academia and pharmaceutical partners are a growing phenomenon within molecular imaging and in particular in the positron emission tomography (PET) radiopharmaceutical community. This cultural shift can be attributed in part to decreased public funding in academia in conjunction with the increased reliance on outsourcing of chemistry, radiochemistry, pharmacology and molecular imaging studies by the pharmaceutical industry. This account highlights some of our personal experiences working with industrial partners to develop new PET radiochemistry methodologies for drug discovery and neuro-PET research studies...
November 2017: Drug Discovery Today. Technologies
https://www.readbyqxmd.com/read/29231149/radiopharmaceuticals-labelled-with-copper-radionuclides-clinical-results-in-human-beings
#4
Giulia Anna Follacchio, Maria Silvia De Feo, Francesco Monteleone, Giuseppe De Vincentis, Mauro Liberatore
Positron emission tomography (PET) is an instrumental diagnostic modality based on the representation (by images or numeric parameters) of the spatial and temporal distribution of molecules labelled with positron-emitting radionuclides. PET makes it possible to study biochemical processes underlying the function of several organs, providing information otherwise achievable only with bioptic assessment. PET has been developed around the positron-emitting radioisotopes of biologically important elements such as carbon, oxygen and nitrogen (11C, 15O, 13N), which enable PET imaging to identify the biodistribution of a wide range of small molecules...
December 11, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29231148/pet-radiopharmaceuticals-in-brazil-and-belarus-economic-comparison-using-the-case-of-18fdg
#5
Sviatoslav Brinkevich, Leonardo Paredes Pires, Filipe Leal Portilho, Ralph Santos-Oliveira
The production of radiopharmaceuticals, especially the PET ones, is a complex combination of economic and social factors. Despite the social aspects, that are essential, the economic issue must be considered and play an important parameter for the implementation and maintenance of producer centers around the world, with especial regards for countries which face economic crisis and/or belongs to aegis of under development countries. In order to evaluate this scenario with carried out this study, comparing a well-established producer center in Brazil and a new on in Belarus...
December 11, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29230857/chemical-aspects-of-metal-ion-chelation-in-the-synthesis-and-application-antibody-based-radiotracers
#6
Eszter Boros, Jason P Holland
Radiometals are becoming increasingly accessible and are utilized frequently in the design of radiotracers for imaging and therapy. Nuclear properties ranging from the emission of γ-ray and ®+ -particles (imaging) to Auger electron, ®- and α-particles (therapy) in combination with long half-lives are ideally matched with the relatively long biological half-life of monoclonal antibodies in vivo. Radiometal labelling of antibodies requires the incorporation of a metal chelate onto the monoclonal antibody...
December 12, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29227813/speed-matters-to-raise-molar-radioactivity-fast-hplc-shortens-the-quality-control-of-c-11-pet-tracers
#7
Lukas Nics, Britta Steiner, Eva-Maria Klebermass, Cecile Philippe, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak
INTRODUCTION: The decision whether an in-house produced short-lived radiopharmaceutical can be applied in-vivo is based on (1) the fulfilment of all quality criteria; (2) the availability of enough radioactivity for subsequent imaging; and (3) a molar activity (MA) above the set limits to guarantee safe administration without competing occupancy of the non-radioactive compound; and (4) an activity concentration, which is high enough for the application in certain preclinical studies. Hence, time reduction can be of major importance to increase final product yields, MA and activity concentrations...
November 21, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29227214/human-reliability-assessment-in-a-99mo-99mtc-generator-production-facility-by-using-standardized-plant-analysis-risk-human-spar-h-technique
#8
Meysam Eyvazlou, Ali Dadashpour Ahangar, Azin Rahimi, Mohammad Reza Davarpanah, Seyed Soheil Sayyahi, Mehdi Mohebali
INTRODUCTION: Reducing human error is an important factor for enhancing safety protocols in various industries. Hence, the analysis of the likelihood of human error in nuclear industries such as radiopharmaceutical production facilities has become more essential. METHODS: This cross-sectional descriptive study was conducted to quantify the probability of human errors in a 99Mo/99mTc generator production facility in Iran. First, through expert interviews, the production process of 99Mo/99mTc generator was analyzed using hierarchical task analysis (HTA) method...
December 11, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29224174/cost-effectiveness-of-treatments-for-the-management-of-bone-metastases-a-systematic-literature-review
#9
REVIEW
Lazaros Andronis, Ilias Goranitis, Sue Bayliss, Rui Duarte
BACKGROUND: Metastatic cancers occur when cancer cells break away from the primary tumour. One of the most common sites of metastasis is the bone, with several therapeutic options currently available for managing bone metastases. In a resource-constrained environment, policy makers and practitioners need to know which options are cost effective. OBJECTIVE: The aim of this systematic review was to review and appraise published economic evaluations on treatments for the management of bone metastases...
December 9, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29222120/targeting-cardiovascular-implant-infection-multimodality-and-molecular-imaging
#10
Jan M Sohns, Udo Bavendiek, Tobias L Ross, Frank M Bengel
Owing to their success in clinical practice, the prevalence of cardiovascular implants is continuously increasing. Implant infection is a relevant complication but remains a diagnostic challenge because echocardiography as a first-line test may be limited. Accordingly, a multimodality approach is increasingly used for diagnostic workup and supported by recent guidelines. As reviewed here, computed tomography and nuclear imaging provide incremental diagnostic value and may be combined in a single hybrid imaging session using positron emission tomography/computed tomography or single photon emission computed tomography/computed tomography...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29205451/subdermal-ultrasound-contrast-agent-injection-for-sentinel-lymph-node-identification-an-analysis-of-safety-and-contrast-agent-dose-in-healthy-volunteers
#11
Priscilla Machado, Maria Stanczak, Ji-Bin Liu, Jason N Moore, John R Eisenbrey, Laurence Needleman, Walter K Kraft, Flemming Forsberg
OBJECTIVES: Mapping of the lymphatic chain for identification of the sentinel lymph node (SLN) is an important aspect of predicting outcomes for patients with breast cancer, and it is usually performed as an intraoperative procedure using blue dye and/or radiopharmaceutical agents. Recently, the use of contrast-enhanced ultrasound (CEUS) has been proposed as an alternative imaging technique for this mapping. The objective of this study was to evaluate the use of subdermal administration of the ultrasound (US) contrast agent Sonazoid (GE Healthcare, Oslo, Norway) in terms of patient safety and to select the dose to be used for lymphatic applications in humans...
December 5, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29196910/radiopharmaceutical-tracers-for-cardiac-imaging
#12
Osamu Manabe, Tatsuya Kikuchi, Arthur J H A Scholte, Mohammed El Mahdiui, Ryuichi Nishii, Ming-Rong Zhang, Eriko Suzuki, Keiichiro Yoshinaga
Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Nuclear myocardial perfusion imaging with either single-photon emission computed tomography or positron emission tomography has been used extensively to perform diagnosis, monitor therapies, and predict cardiovascular events. Several radiopharmaceutical tracers have recently been developed to evaluate CVD by targeting myocardial perfusion, metabolism, innervation, and inflammation. This article reviews old and newer used in nuclear cardiac imaging...
December 1, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29190900/immuno-pet-imaging-based-radioimmunotherapy-in-head-and-neck-squamous-cell-carcinoma-model
#13
In Ho Song, Youn Noh, Junhye Kwon, Jae Ho Jung, Byung Chul Lee, Kwang Il Kim, Yong Jin Lee, Joo Hyun Kang, Chae Seo Rhee, Chul Hee Lee, Tae Sup Lee, Ik Joon Choi
The epidermal growth factor receptor (EGFR) is one of the most comprehensively studied molecular targets in head and neck squamous cell carcinoma (HNSCC). However, inherent and acquired resistance are serious problems and are responsible for limited clinical efficacy and tumor recurrence. In this study, we evaluated the feasibility of immuno-positron emission tomography (PET) imaging and radioimmunotherapy (RIT) with 64Cu-/177Lu-PCTA-cetuximab in cetuximab-resistant SNU-1066 HNSCC xenografted model. The cellular uptake of 64Cu/177Lu-3,6,9,15-tetraazabicyclo[9...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29189371/ectopic-adrenocorticotropic-hormone-secreting-pituitary-adenoma-localized-by-18f-choline-pet-ct
#14
Alessandro Sindoni, Valentina Bodanza, Rosa Tatta, Tanja Baresic, Eugenio Borsatti
The criterion standard of treatment of an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma is complete surgical excision. However, ectopic location of these adenomas is an extremely rare condition, which may affect the diagnosis and treatment success. We report a case of a 49-year-old man who was referred to our institution with persistent hypercortisolemia after an unsuccessful attempt of surgical resection. F-choline PET/CT revealed increased radiopharmaceutical uptake in a nodule localized in the left maxillary sinus, which was proved at histology to be an ectopic ACTH-secreting pituitary adenoma staining positive for ACTH...
November 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29186617/population-radiation-exposure-from-diagnostic-nuclear-medicine-procedures-in-tehran-2011-14-trends-in-the-last-3-decades
#15
Faraj Tabeie, Parisa Honari, Isa Neshandar Asli, Mahasti Amoei, Mohammad Eftekhari, Mojtaba Ansari, Babak Shafiei
This study represents an update of Tehran population exposure from the diagnostic nuclear medicine procedures and the annual collective effective dose during 2011-14. The diagnostic nuclear medicine procedures data were collected from 58 out of 60 nuclear medicine centers in Tehran and were composed of the type and frequency of diagnostic examinations, radiopharmaceuticals used, administered activities, and age distribution of the patients. The annual number of examinations per 1000 population increased from 13...
November 24, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29177263/primary-radiation-dosimetry-of-a-novel-pet-radiopharmaceutical-68ga-nodaga-glycine-in-comparison-with-99mtc-dtpa-in-renal-studies
#16
Mohsen Cheki, Hariprasad Gali
OBJECTIVE: In this study, we tried to estimate human absorbed dose of 68Ga-NODAGA-glycine as a new potential positron emission tomography (PET) renal agent based on the biodistribution data reported in healthy rats, and compare our estimation with the available absorbed dose data from technetium-99m-diethylenetriaminepentaacetic acid (99mTc-DTPA). SUBJECTS AND METHODS: The medical internal radiation dose (MIRD) formulation was applied to extrapolate from rats to human and to project the absorbed radiation dose for various organs in humans...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29175213/a-new-therapeutic-proposal-for-inoperable-osteosarcoma-photodynamic-therapy
#17
Guilherme Chohfi de Miguel, Ana Margarida Abrantes, Mafalda Laranjo, Ana Yoshie Kitagawa Grizotto, Bruno Camporeze, José Aires Pereira, Gonçalo Brites, Arménio Serra, Marta Pineiro, António Rocha-Gonsalves, Maria Filomena Botelho, Denise Gonçalves Priolli
BACKGROUND: Osteosarcoma, a malignant tumor characterized by bone or osteoid formation, is the second most common primary bone neoplasm. Clinical symptoms include local and surrounding pain, unrelieved by rest or anesthesia. Osteosarcoma has a poor chemotherapeutic response with prognosis dependent on complete tumor excision. Therefore, for inoperable osteosarcoma new therapeutic strategies are needed. The present study aimed to develop murine models of cranial and vertebral osteosarcoma that facilitate simple clinical monitoring and real-time imaging to evaluate the outcome of photodynamic therapy based on a previously developed photosensitizer...
November 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29173814/absorbed-doses-in-humans-from-188re-rituximab-in-the-free-form-and-bound-to-superparamagnetic-iron-oxide-nanoparticles-biodistribution-study-in-mice
#18
Bakhtiar Azadbakht, Hossein Afarideh, Mohammad Ghannadi-Maragheh, Ali Bahrami-Samani, Hassan Yousefnia
Absorbed doses to human organs from 188Re-Rituximab in the free form and bound to superparamagnetic iron oxide nanoparticles were predicted from results of the radiopharmaceutical biodistribution studies in mice by the RADAR method. Overall, equivalent and effective doses to human organs from the radiopharmaceutical on the nanoparticles were higher because of the enhanced permeability and retention effect. Liver, spleen and kidneys received higher equivalent doses than other organs (5.29, 3.70 and 3.06mSv/MBq, respectively, for the free radiopharmaceutical and 6...
October 23, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29173155/imaging-of-bacteria-is-there-any-hope-for-the-future-based-on-past-experience
#19
Thomas Ebenhan, Elena Lazzeri, Olivier Gheysens
Infectious diseases remain a major health problem and cause of death worldwide. It is expected that the socio-economic impact will further intensify due to escalating resistance to antibiotics, an ageing population and an increase in the number of patients under immunosuppressive therapy and implanted medical devices. Even though radiolabeled probes and leukocytes are routinely used in clinical practice, it might still be difficult to distinguish sterile inflammation from inflammation caused by bacteria. Moreover, the majority of these probes are based on the attraction of leukocytes which may be hampered in neutropenic patients...
November 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29166756/use-of-imaging-techniques-in-large-vessel-vasculitis-and-related-conditions
#20
Annibale Versari, Nicolò Pipitone, Massimiliano Casali, Francois Jamar, Giulia Pazzola
Giant Cell Arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) primarily affecting the aorta and its major branches, mainly differentiated by the onset age (>50 years GCA and <40 years TA). In addition, temporal artery involvement and polymyalgia rheumatic are typical features of GCA, but not TA. Imaging techniques are required to secure the diagnosis of large-vessel vasculitides, and to monitor the disease course. Both morphological and metabolic imaging are involved. Morphological imaging is represented mainly by Computerized Tomography (CT), CT angiography, Magnetic Resonance (MR), MR angiography, Color-Doppler Sonography (CDS) and high-resolution CDS...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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