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https://www.readbyqxmd.com/read/29909578/ferdinando-calabria-and-orazio-schillaci-eds-radiopharmaceuticals-metabolic-pathways-for-pet-ct-and-pet-mri-imaging-servizi-scientifici-roma-2018-isbn-978-88-99117-03-0
#1
Michelangelo Bombaci, Luigi Mansi
No abstract text is available yet for this article.
June 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29892268/treatment-for-patients-with-malignant-pheochromocytomas-and-paragangliomas-a-perspective-from-the-hallmarks-of-cancer
#2
REVIEW
Camilo Jimenez
Malignant pheochromocytomas and paragangliomas affect a very small percentage of the general population. A substantial number of these patients have a hereditary predisposition for the disease and consequently, bear the risk of developing these tumors throughout their entire lives. It is, however, unclear why some patients with no hereditary predisposition develop these tumors, which frequently share a similar molecular phenotype with their hereditary counterparts. Both hereditary and sporadic tumors usually appear at an early age, and affected people often die before reaching their expected lifespans...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29887768/the-place-of-pet-to-assess-new-therapeutic-effectiveness-in-neurodegenerative-diseases
#3
REVIEW
Anne-Claire Dupont, Bérenger Largeau, Denis Guilloteau, Maria Joao Santiago Ribeiro, Nicolas Arlicot
In vivo exploration of neurodegenerative diseases by positron emission tomography (PET) imaging has matured over the last 20 years, using dedicated radiopharmaceuticals targeting cellular metabolism, neurotransmission, neuroinflammation, or abnormal protein aggregates (beta-amyloid and intracellular microtubule inclusions containing hyperphosphorylated tau). The ability of PET to characterize biological processes at the cellular and molecular levels enables early detection and identification of molecular mechanisms associated with disease progression, by providing accurate, reliable, and longitudinally reproducible quantitative biomarkers...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29873506/clinical-evaluation-of-68-ga-psma-ii-and-68-ga-rm2-pet-images-reconstructed-with-an-improved-scatter-correction-algorithm
#4
Kristen A Wangerin, Lucia Baratto, Mohammad Mehdi Khalighi, Thomas A Hope, Praveen K Gulaka, Timothy W Deller, Andrei H Iagaru
OBJECTIVE: Gallium-68-labeled radiopharmaceuticals pose a challenge for scatter estimation because their targeted nature can produce high contrast in these regions of the kidneys and bladder. Even small errors in the scatter estimate can result in washout artifacts. Administration of diuretics can reduce these artifacts, but they may result in adverse events. Here, we investigated the ability of algorithmic modifications to mitigate washout artifacts and eliminate the need for diuretics or other interventions...
June 6, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29866344/a-monte-carlo-model-for-the-internal-dosimetry-of-choroid-plexuses-in-nuclear-medicine-procedures
#5
Ernesto Amato, Francesco Cicone, Lucrezia Auditore, Sergio Baldari, John O Prior, Silvano Gnesin
Choroid plexuses are vascular structures located in the brain ventricles, showing specific uptake of some diagnostic and therapeutic radiopharmaceuticals currently under clinical investigation, such as integrin-binding arginine-glycine-aspartic acid (RGD) peptides. No specific geometry for choroid plexuses has been implemented in commercially available software for internal dosimetry. The aims of the present study were to assess the dependence of absorbed dose to the choroid plexuses on the organ geometry implemented in Monte Carlo simulations, and to propose an analytical model for the internal dosimetry of these structures for 18 F, 64 Cu, 67 Cu, 68 Ga, 90 Y, 131 I and 177 Lu nuclides...
May 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29862405/bispidines-for-radiopharmaceuticals
#6
Peter Comba, Marion Kerscher, Katharina Rück, Miriam Starke
Very rigid tetra-, penta-, hexa-, hepta- and octadentate bispidine ligands are well preorganized for specific coordination geometries. The broad range of coordination numbers, geometries and donor sets allows one to design and prepare bispidines for many specific metal ions and applications. Major requirements for radiopharmaceuticals are efficient labeling, inertness under physiological conditions and easy functionalization of the ligands with biological vectors. The reasons why bispidines are among the most favorable chelators for radiopharmaceutical applications, a comprehensive list of bispidine ligands and a range of examples where bispidines have been used to develop radiopharmaceuticals for future applications in diagnosis and therapy are discussed...
June 4, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29859504/targeted-alpha-therapy-using-radium-223-from-physics-to-biological-effects
#7
REVIEW
I A Marques, A R Neves, A M Abrantes, A S Pires, E Tavares-da-Silva, A Figueiredo, M F Botelho
With the advance of the use of ionizing radiation in therapy, targeted alpha therapy (TAT) has assumed an important role around the world. This kind of therapy can potentially reduce side effects caused by radiation in normal tissues and increased destructive radiobiological effects in tumor cells. However, in many countries, the use of this therapy is still in a pioneering phase. Radium-223 (223 Ra), an alpha-emitting radionuclide, has been the first of its kind to be approved for the treatment of bone metastasis in metastatic castration-resistant prostate cancer...
May 25, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29849748/online-appointment-scheduling-for-a-nuclear-medicine-department-in-a-chinese-hospital
#8
Qian Xiao, Li Luo, Shu-Zhen Zhao, Xiao-Bin Ran, Ya-Bing Feng
Nuclear medicine, a subspecialty of radiology, plays an important role in proper diagnosis and timely treatment. Multiple resources, especially short-lived radiopharmaceuticals involved in the process of nuclear medical examination, constitute a unique problem in appointment scheduling. Aiming at achieving scientific and reasonable appointment scheduling in the West China Hospital (WCH), a typical class A tertiary hospital in China, we developed an online appointment scheduling algorithm based on an offline nonlinear integer programming model which considers multiresources allocation, the time window constraints imposed by short-lived radiopharmaceuticals, and the stochastic nature of the patient requests when scheduling patients...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29796026/a-systematic-review-of-clinical-practice-guidelines-for-castration-resistant-prostate-cancer
#9
Mohamad Javad Foroughi Moghadam, Saeed Taheri, Farzad Peiravian
Cancer constitutes a huge burden on societies in countries with any level of economic development. Prostate cancer is the first most diagnosed cancer of men in developed countries and the forth one in developing countries in terms of incidence rate. It is also the third incident cancer of men in Iran along with a prevalence of about 10,000 cases. Castration-resistant prostate cancer (CRPC) is a severe stage of the disease with a number of newly discovered treatment options. These therapeutic alternatives including abiraterone acetate, enzalutamide, cabazitaxel, immunotherapy with sipuleucel-T, radiopharmaceuticals and bone-targeted therapies (zoledronic acid, denosumab) along with docetaxel have made the decision making process complex and challenging for clinicians...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29794396/-the-39th-report-on-survey-of-the-adverse-reaction-to-radiopharmaceuticals-the-42nd-survey-in-2016
#10
Hiroshi Matsuda, Tomoya Uehara, Hidehiko Okazawa, Sunao Mizumura, Kunihiko Yokoyama, Mana Yoshimura
This survey was performed to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2016 in Japan. It was based on responses to questionnaires sent to nuclear medicine institutions. The reply was obtained from 977 institutions among 1,235 to which the questionnaire had been sent. Nine cases of adverse reactions were reported. A total of 1,052,650 radiopharmaceutical administrations was reported. The incidence of adverse reactions per 100,000 cases was 0.9. No case of deficient products was reported...
2018: Kaku Igaku. the Japanese Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29790486/-simplicity-or-complexity-of-the-radiopharmaceutical-production-process-in-the-light-of-optimization-of-radiation-protection-of-staff-sup-99m-sup-tc-vs-sup-18-sup-f
#11
Małgorzata Wrzesień
BACKGROUND: A radiopharmaceutical is a combination of a non-radioactive compound with a radioactive isotope. Two isotopes: technetium- 99m (<sup>99m</sup>Tc) and fluorine-18 (<sup>18</sup>F) are worth mentioning on the rich list of isotopes which have found numerous medical applications. Their similarity is limited only to the diagnostic area of applicability. The type and the energy of emitted radiation, the half-life and, in particular, the production method demonstrate their diversity...
May 22, 2018: Medycyna Pracy
https://www.readbyqxmd.com/read/29787892/the-role-of-bisphosphonates-or-denosumab-in-light-of-the-availability-of-new-therapies-for-prostate-cancer
#12
REVIEW
Fred Saad, Cora N Sternberg, Peter F A Mulders, Daniela Niepel, Bertrand F Tombal
Most men with advanced prostate cancer will develop bone metastases, which have a substantial impact on quality of life. Bone metastases can lead to skeletal-related events (SREs), which place a burden on patients and healthcare systems. For men with castration-resistant prostate cancer (CRPC) and bone metastases, the treatment landscape has evolved rapidly over the past few years. The relatively recent approvals of the hormonal agents abiraterone acetate and enzalutamide, second-line chemotherapy cabazitaxel, and the radiopharmaceutical radium-223 dichloride (radium-223), have provided clinicians with a greater choice of treatments...
May 3, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29787786/preparation-of-99m-tc-levetiracetam-intranasal-microemulsion-as-the-first-radiotracer-for-spect-imaging-of-the-synaptic-vesicle-protein-sv2a
#13
Hassan M Rashed, Rehab N Shamma, Hanan A El-Sabagh
Selective receptors imaging using gamma emitting radiopharmaceuticals allows accurate diagnosis and follow up of many brain related disorders. Levetiracetam, a selective SV2A receptor antiepileptic, was successfully radiolabeled using 99m Tc. Different conditions affecting the labelling process were studied and optimum radiochemical yield of 89.8% was obtained. 99m Tc-levetiracetam was effectively formulated and characterized as microemulsion with particle size of 16.34 ± 5.58 nm and polydispersity index of 0...
May 19, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29777899/congenital-dyshormonogenic-hypothyroidism-with-goiter-caused-by-a-sodium-iodide-symporter-slc5a5-mutation-in-a-family-of-shih-tzu-dogs
#14
E A Soler Arias, V A Castillo, J D Garcia, J C Fyfe
An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. The only sign of hypothyroidism was a moderate growth delay in the adult dog. The ITD was recognized by the absence of uptake of technetium-99m in the salivary glands (sg) and goiter observed by scintigraphy. In the same scan, radiopharmaceutical uptake was found in the anterior mediastinum of both dogs and in the right axillary lymph node in the oldest dog...
April 24, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29777523/application-of-cu-64-nodaga-psma-pet-in-prostate-cancer
#15
Sabina Sevcenco, Hans Christoph Klingler, Klaus Eredics, Alexander Friedl, Jenifer Schneeweiss, Peter Knoll, Thomas Kunit, Lukas Lusuardi, Siroos Mirzaei
INTRODUCTION: The high diagnostic potential of 64 Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64 Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer. METHODS: A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29777007/development-of-64-cu-nota-trastuzumab-for-her2-targeting-radiopharmaceutical-with-improved-pharmacokinetics-for-human-study
#16
Sang-Keun Woo, Su Jin Jang, Min-Jung Seo, Ju Hui Park, Byoung Soo Kim, Eun Jung Kim, Yong Jin Lee, Tae Sup Lee, Gwang Il An, In Ho Song, Youngho Seo, Kwang Il Kim, Joo Hyun Kang
Purpose The purpose of this study was to develop 64 Cu-labeled trastuzumab with improved pharmacokinetics for human epidermal growth factor receptor 2. Methods Trastuzumab was conjugated with SCN-Bn-NOTA and radiolabeled with 64 Cu. Serum stability and immunoreactivity of 64 Cu-NOTA-trastuzumab were tested. Small animal PET imaging and biodistribution study were performed in HER2-positive breast cancer xenograft model (BT-474). Internal dosimetry of experimental animals was performed using the image-based approach with the Monte Carlo N-Particle Code...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29772064/impact-of-inter-patient-variability-on-organ-dose-estimates-according-to-mird-schema-uncertainty-and-variance-based-sensitivity-analysis
#17
Alexandra Zvereva, Florian Kamp, Helmut Schlattl, Maria Zankl, Katia Parodi
PURPOSE: Variance-based sensitivity analysis (SA) is described and applied to the radiation dosimetry model proposed by the Committee on Medical Internal Radiation Dose (MIRD) for the organ-level absorbed dose calculations in nuclear medicine. The uncertainties in the dose coefficients thus calculated are also evaluated. METHODS: A Monte Carlo approach was used to compute first-order and total-effect SA indices, which rank the input factors according to their influence on the uncertainty in the output organ doses...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29771470/antibody-based-radiopharmaceuticals-for-imaging-and-therapy
#18
Jason P Holland
No abstract text is available yet for this article.
May 17, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29766779/technetium-99m-based-radiopharmaceuticals-in-sentinel-lymph-node-biopsy-gynecologic-oncology-perspective
#19
Kamil Zalewski, Malgorzata Benke, Bartlomiej Mirocha, Jakub Radziszewski, Magdalena Chechlinska, Magdalena Kowalewska
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN involvement benefit from extensive lymphadenectomy in terms of prolonged survival. Moreover, overtreatment of patients with localized disease carries unnecessary risk of complications...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29756024/preparation-and-preclinical-evaluation-of-a-68-ga-labelled-c-rgdfk-conjugate-comprising-the-bifunctional-chelator-nodia-me
#20
Tilman Läppchen, Jason P Holland, Yvonne Kiefer, Mark D Bartholomä
Background: We recently developed a chelating platform based on the macrocycle 1,4,7-triazacyclononane with up to three, five-membered azaheterocyclic arms for the development of 68 Ga- and 64 Cu-based radiopharmaceuticals. Here, a 68 Ga-labelled conjugate comprising the bifunctional chelator NODIA-Me in combination with the αv ß3 -targeting peptide c(RGDfK) has been synthesized and characterized. The primary aim was to evaluate further the potential of our NODIA-Me chelating system for the development of 68 Ga-labelled radiotracers...
2018: EJNMMI Radiopharmacy and Chemistry
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