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https://www.readbyqxmd.com/read/28721305/fully-automated-gmp-production-of-68-ga-ga-do3a-vs-cys-40-exendin-4-for-clinical-use
#1
Irina Velikyan, Ulrika Rosenstrom, Olof Eriksson
[(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4/PET-CT targeting glucagon like peptide-1 receptor (GLP-1R) has previously demonstrated its potential clinical value for the detection of insulinomas. The production and accessibility of this radiopharmaceutical is one of the critical factors in realization of clinical trials and routine clinical examinations. Previously, the radiopharmaceutical was prepared manually, however larger scale of clinical trials and healthcare requires automation of the production process in order to limit the operator radiation dose as well as improve tracer manufacturing robustness and on-line documentation for enhanced good manufacturing practice (GMP) compliance...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28719177/classics-in-neuroimaging-imaging-the-dopaminergic-pathway-with-pet
#2
Meghna Kanthan, Paul Cumming, Jacob M Hooker, Neil Vasdev
The success of positron emission tomography (PET) for observing molecular processes underlying brain function and disease is underpinned by radiotracer chemistry. From the earliest applications of PET to measure dopamine synthesis capacity and the abundance of neuroreceptors and transporters, to the more recent topic of dynamic neurochemical imaging, interrogation of brain dopamine in conditions such as neurodegenerative diseases, schizophrenia, mood disorders, and addictions has been a driving force that challenges the ingenuity of radiopharmaceutical scientists...
July 18, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28714296/-68-ga-somatostatin-analogue-pet-ct-analysis-of-costs-and-benefits-in-a-public-hospital-setting
#3
Tatiana Segard, Laurence Mja Morandeau, Elizabeth A Geelhoed, Roslyn J Francis
INTRODUCTION: Between 2009 and 2012, (68) Ga-somatostatin analogue PET-CT progressively replaced (111) In-octreotide scintigraphy for imaging neuroendocrine tumours in WA public hospitals due to published literature demonstrating improved diagnostic accuracy and increased availability. Despite significantly improved sensitivity and specificity, (68) Ga-somatostatin analogue PET is currently unfunded in Australia. This study sought to undertake cost analysis of the two modalities in a public hospital setting and to compare them with regard to patient factors such as imaging time and radiation dose...
July 17, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28711759/dft-study-of-the-interaction-between-dota-chelator-and-competitive-alkali-metal-ions
#4
E Frimpong, A A Skelton, B Honarparvar
1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid (DOTA) is an important chelator for radiolabeling of pharmaceuticals. The ability of alkali metals found in the body to complex with DOTA and compete with radio metal ions can alter the radiolabeling process. Non-covalent interactions between DOTA complexed with alkali metals Li(+), Na(+), K(+) and Rb(+), are investigated with density functional theory using B3LYP and ωB97XD functionals. Conformational possibilities of DOTA were explored with a varying number of carboxylic pendant arms of DOTA in close proximity to the ions...
June 29, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28711565/new-aspects-of-molecular-imaging-in-prostate-cancer
#5
Francesco Ceci, Paolo Castellucci, Juliano J Cerci, Stefano Fanti
Nowadays several new imaging modalities are available for investigating prostate cancer (PCa) such as magnet resonance imaging (MRI) in the form of whole body MRI and pelvic multiparametric MRI and positron emission tomography (PET) using choline as radiotracers. Nevertheless, these modalities proved sub-optimal accuracy for detecting PCa metastases, particularly in the recurrence setting. A new molecular probe targeting the prostate specific membrane antigen (PSMA) has been recently developed for PET imaging...
July 12, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28705929/use-of-tc-99m-tilmanocept-as-a-single-agent-for-sentinel-lymph-node-identification-in-breast-cancer-a-retrospective-pilot-study
#6
Jonathan Takei Unkart, Anne Marie Wallace
Introduction: Tc-99m tilmanocept (TcTM) received recent FDA-approval for lymphatic mapping. However, no prior studies have evaluated the use of TcTM as a single agent in sentinel lymph node (SLN) biopsy in breast cancer. Methods: We executed this retrospective, pilot study to assess the ability of TcTM to identify sentinel nodes as a single agent in clinically node-negative breast cancer patients. Patients received a single, intradermal injection overlying the tumor of either 0.5 mCi TcTM the day-of surgery or 2...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28705928/miniaturized-radiochemical-purity-testing-for-99m-tc-hmpao-99m-tc-hmdp-and-99m-tc-tetrofosmin
#7
Ana de la Fuente, Roberta Zanca, Angela Gabriella Cataldi, Roberto Boni, Martina Sollini, Elena Lazzeri, Giuliano Mariani, Paola Anna Erba
Quick methods are functional in clinical practice in order to ensure the fastest availability of radiopharmaceuticals. For this purpose, we investigated the radiochemical purity of the widely used (99m)Tc-HMDP (hydroxymethylene diphosphonate), (99m)Tc-HMPAO (hexamethylpropyleneamine oxime) and (99m)Tc-Tetrofosmin by reducing time as compared to the manufacturer's method. Methods: We applied a miniaturized chromatographic method with a reduced strip development from 18 cm to 9 cm for all three radiopharmaceuticals...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28704342/a-novel-compact-small-field-of-view-hybrid-gamma-camera-first-clinical-results
#8
Aik H Ng, Patricia E Blackshaw, Mohammed S Alqahtani, Layal K Jambi, Sarah L Bugby, John E Lees, Alan C Perkins
INTRODUCTION: Hybrid imaging has proven to be a major innovation in nuclear medicine, allowing the fusion of functional information with anatomical detail. In the past, the use of hybrid imaging such as PET-CT, PET-MRI and SPECT-CT has been of great clinical benefit; however, these scanners are relatively large and bulky. We have developed and investigated the clinical application of a compact small field of view hybrid gamma camera (HGC) that is suitable for small-organ imaging at the patient bedside...
July 12, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28703233/copper-complexes-with-dissymmetrically-substituted-bis-thiosemicarbazone-ligands-as-a-basis-for-pet-radiopharmaceuticals-control-of-redox-potential-and-lipophilicity
#9
Oliver C Brown, Julia Baguña Torres, Katherine B Holt, Philip J Blower, Michael J Went
Copper(ii) bis(thiosemicarbazone) derivatives have been used extensively in positron emission tomography (PET) to image hypoxia and blood flow and to radiolabel cells for cell tracking. These applications depend on control of redox potentials and lipophilicity of the bis(thiosemicarbazone) complexes, which can be adjusted by altering peripheral ligand substituents. This paper reports the synthesis of a library of new dissymmetrically substituted bis(thiosemicarbazone) ligands by controlling the condensation reactions between dicarbonyl compounds and 4-substituted-3-thiosemicarbazides or using acetal protection...
July 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28702664/fast-and-cost-effective-cyclotron-production-of-61-cu-using-a-nat-zn-liquid-target-an-opportunity-for-radiopharmaceutical-production-and-r-d
#10
S J C do Carmo, V H P Alves, F Alves, A J Abrunhosa
Following our previous work on the production of radiometals, such as (64)Cu and (68)Ga, through the irradiation of liquid targets using a medical cyclotron, we describe in this paper a technique to produce (61)Cu through the irradiation of natural zinc using a liquid target. The proposed method is very cost-effective, as it avoids the use of expensive enriched material, and is fast, as a purified solution of (61)CuCl2 is obtained in less than 30 min after the end of beam. Considering its moderate half-life of 3...
July 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28702073/mathematical-simulation-of-transport-kinetics-of-tumor-imaging-radiopharmaceutical-99m-tc-mibi
#11
O N Shevtsova, V K Shevtsova
The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical (99m)Tc-MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be easily tested by the concentration data of the radioactive pharmaceuticals in the blood measured at early time point and late time point of the scanning, and the obtained data can be used for determination of the washout rate coefficient which is one of the existing oncology diagnostics methods...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28701709/psma-expression-by-microvasculature-of-thyroid-tumors-potential-implications-for-psma-theranostics
#12
Andrey Bychkov, Usanee Vutrapongwatana, Supatporn Tepmongkol, Somboon Keelawat
Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer epithelium, making it a promising target for molecular imaging and therapy. Recently, several studies found unexpected PSMA radiotracer uptake by thyroid tumors, including radioiodine-refractory (RAIR) cancers. PSMA expression was reported in tumor-associated endothelium of various malignancies, however it has not been systematically addressed in thyroid tumors. We found that PSMA was frequently expressed in microvessels of thyroid tumors (120/267), but not in benign thyroid tissue...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695567/tc-99m-tilmanocept-versus-tc-99m-sulfur-colloid-in-breast-cancer-sentinel-lymph-node-identification-results-from-a-randomized-blinded-clinical-trial
#13
Jonathan T Unkart, Ava Hosseini, Anne M Wallace
INTRODUCTION: No prior trials have compared sentinel lymph node (SLN) identification outcomes between Tc-99m tilmanocept (TcTM) and Tc-99m sulfur colloid (TcSC) in breast cancer (BC). METHODS: We report on the secondary outcomes from a randomized, double-blinded, single surgeon clinical trial comparing post-injection site pain between TcTM and TcSC. Patients were randomized to receive a preoperative single, peritumoral intradermal injection of TcTM or TcSC. The number of total, "hot", and blue nodes detected and removed were compared between groups...
July 10, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28688023/-pet-ct-and-pet-mri-of-the-prostate-from-18-f-fdg-to-68-ga-psma
#14
REVIEW
K Knorr, M Eiber, T Maurer, H-J Wester, K Scheidhauer
CLINICAL/METHODICAL ISSUE: In the last few years nuclear medical diagnostics have experienced a unprecedented renaissance in the diagnostics of prostate cancer, due to the availability of hybrid imaging with positron emission tomography computed tomography (PET/CT), PET magnetic resonance imaging (PET/MRI) and single photon emission computed tomography (SPECT) CT as well as the development of prostate-specific radiopharmaceuticals. METHODICAL INNOVATIONS: The use of fluorodeoxyglucose (FDG), which has been successfully implemented for many years in PET diagnostics, is only helpful in dedifferentiated tumors due to the biological characteristics of prostate cancer...
July 7, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28687866/quantification-improvement-and-harmonization-of-small-lesion-detection-with-state-of-the-art-pet
#15
REVIEW
Charlotte S van der Vos, Daniëlle Koopman, Sjoerd Rijnsdorp, Albert J Arends, Ronald Boellaard, Jorn A van Dalen, Mark Lubberink, Antoon T M Willemsen, Eric P Visser
In recent years, there have been multiple advances in positron emission tomography/computed tomography (PET/CT) that improve cancer imaging. The present generation of PET/CT scanners introduces new hardware, software, and acquisition methods. This review describes these new developments, which include time-of-flight (TOF), point-spread-function (PSF), maximum-a-posteriori (MAP) based reconstruction, smaller voxels, respiratory gating, metal artefact reduction, and administration of quadratic weight-dependent (18)F-fluorodeoxyglucose (FDG) activity...
July 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28683361/-211-at-labeled-substance-p-5-11-as-potential-radiopharmaceutical-for-glioma-treatment
#16
Monika Lyczko, Marek Pruszynski, Agnieszka Majkowska-Pilip, Krzysztof Lyczko, Bogdan Was, Sylwia Meczynska-Wielgosz, Marcin Kruszewski, Katarzyna Szkliniarz, Jerzy Jastrzebski, Anna Stolarz, Aleksander Bilewicz
INTRODUCTION: The purposes of the present work were to label substance P (5-11) with (211)At using a rhodium(III) complex with a bifunctional ligand-2-(1,5,9,13-tetrathiacyclohexadecan-3-yloxy)acetic acid ([16aneS4]-COOH) and to assess the in vitro stability and toxicity of the obtained radiobioconjugate. METHODS: Two approaches were evaluated to obtain (131)I/(211)At-Rh[16aneS4]-SP5-11 radiobioconjugates, based on 2-step and 1-step syntheses. In the first method (131)I/(211)At-Rh[16aneS4]-COOH complexes were obtained that required further coupling to a biomolecule...
May 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28683356/scintigraphic-imaging-of-staphylococcus-aureus-infection-using-99m-tc-radiolabeled-aptamers
#17
Sara Roberta Dos Santos, Camila Maria de Sousa Lacerda, Iêda Mendes Ferreira, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S...
June 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28680210/incidentally-detected-thyroid-follicular-neoplasm-on-somatostatin-receptor-imaging-and-post-therapy-scan
#18
Apurva Sood, Harpreet Singh, Ashwani Sood, Rajender Kumar Basher, Bhagwant Rai Mittal
Peptide receptor radionuclide therapy (PRRT) either using Lu-177 or Y-90 peptide radiopharmaceuticals has emerged as promising treatment modality in patients with inoperable metastatic neuroendocrine tumour (NET) including medullary thyroid cancer, because of overexpression of somatostatin receptor 2 (sstr-2) on these cells. The several investigators have used PRRT in non-iodine avid differentiated thyroid cancer patients with limited success, where other treatment modalities have failed, probably due to faint sstr-2 expression in these lesions...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28676277/standardization-of-68-ge-68-ga-using-the-4%C3%AF-%C3%AE-%C3%AE-coincidence-method-based-on-cherenkov-counting
#19
C Bobin, C Thiam, J Bouchard
In the framework of an international BIPM comparison (Bureau International des Poids et Mesures), the activity standardization of (68)Ge in a solution of (68)Ge/(68)Ga in equilibrium provided by NIST was carried out at LNHB. This exercise was organized to meet the growing interest in (68)Ga as a radiopharmaceutical in nuclear medicine services (e.g. as a surrogate of (18)F for PET imaging). Due to the volatility of germanium, the activity standardization of (68)Ge was investigated at LNHB by means of 4πβ-γ coincidence counting based on Cherenkov measurements...
June 29, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28673474/new-developments-and-future-challenges-of-nuclear-medicine-and-molecular-imaging-for-pulmonary-embolism
#20
Pierre-Yves Le Roux, Philippe Robin, Pierre-Yves Salaun
Although widely validated, current tests for pulmonary embolism (PE) diagnosis, i.e. computed tomography pulmonary angiography (CTPA) and V/Q planar scintigraphy, have some limitations. Drawbacks of CTPA include the radiation dose, some contra indications and a rising concern about a possible overdiagnosis/overtreatment of PE. On the other hand, V/Q planar scintigraphy has a high rate of non-diagnostic tests responsible for complex diagnostic algorithms. Since the PIOPED study, imaging equipment and radiopharmaceuticals have greatly evolved allowing the introduction of techniques that improve imaging of lung ventilation and perfusion...
June 27, 2017: Thrombosis Research
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