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https://www.readbyqxmd.com/read/27910132/a-simple-method-for-preparation-of-pure-68-ga-acetate-precursor-for-formulation-of-radiopharmaceuticals-physicochemical-characteristics-of-the-68-ga-eluate-of-the-sno2-based-68-ge-68-ga-column-generator
#1
Sankha Chattopadhyay, Md Neyar Alam, Madhu Smita, Umesh Kumar, Sujata Saha Das, Luna Barua
Gallium-68 radioisotope is an excellent source in clinical positron emission tomography application due to its ease of availability from germanium-68 ((68) Ge)/gallium-68 ((68) Ga) generator having a shelf life of 1 year. In this paper, a modified method for purification of the primary eluate of (68) Ge-(68) Ga generator by using a small cation exchange resin (Dowex-50) column has been described. The breakthrough of (68) Ge before and after purification of (68) Ga eluate was 0.014% and 0.00027%, respectively...
December 1, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27909712/myocardial-perfusion-spect-2015-in-germany-results-of-the-7th-survey
#2
Oliver Lindner, Wolfgang Burchert, Wolfgang Schäfer, Marcus Hacker
AIM: The working group Cardiovascular Nuclear Medicine of the German Society of Nuclear Medicine presents the results of the 7th survey of myocardial perfusion SPECT (MPS) of the reporting year 2015. METHOD: 268 questionnaires (173 practices [PR], 67 hospitals [HO], 28 university hospitals [UH]) were evaluated. Results of the last survey from 2012 are set in squared brackets. RESULTS: MPS of 121 939 [105 941] patients were reported. 98 % [95 %] of all MPS were performed with Tc-99m radiopharmaceuticals and 2 % [5 %] with Tl-201...
December 2, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27909182/2016-update-of-the-north-american-consensus-guidelines-for-pediatric-administered-radiopharmaceutical-activities
#3
S Ted Treves, Michael J Gelfand, Frederic H Fahey, Marguerite T Parisi
No abstract text is available yet for this article.
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27908190/accuracy-reproducibility-and-uncertainty-analysis-of-thyroid-probe-based-activity-measurements-for-determination-of-dose-calibrator-settings
#4
Pedro L Esquinas, Jesse Tanguay, Marjorie Gonzalez, Milan Vuckovic, Cristina Rodríguez-Rodríguez, Urs O Häfeli, Anna Celler
PURPOSE: In the nuclear medicine department, the activity of radiopharmaceuticals is measured using dose calibrators (DCs) prior to patient injection. The DC consists of an ionization chamber that measures current generated by ionizing radiation (emitted from the radiotracer). In order to obtain an activity reading, the current is converted into units of activity by applying an appropriate calibration factor (also referred to as DC dial setting). Accurate determination of DC dial settings is crucial to ensure that patients receive the appropriate dose in diagnostic scans or radionuclide therapies...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27907840/clinical-68-ga-pet-is-radiosynthesis-module-an-absolute-necessity
#5
Rubel Chakravarty, Sudipta Chakraborty, E R Radhakrishnan, Koramadai Kamaleshwaran, Ajit Shinto, Ashutosh Dash
INTRODUCTION: The commercially available (68)Ge/(68)Ga generators are generally used in clinical context in conjunction with automated or semi-automated modules for the syntheses of (68)Ga radiopharmaceuticals. It is desirable to develop strategies for the formulation of (68)Ga-radiopharmaceuticals without use of such expensive modules in order to make (68)Ga-based clinical positron emission tomography (PET) more popular and affordable worldwide. METHODS: An organic matrix based (68)Ge/(68)Ga generator was used for preparation of clinically relevant doses of four different (68)Ga-based radiopharmaceuticals, namely (68)Ga-DOTA-NOC, (68)Ga-NODAGA-RGD2, (68)Ga-PSMA-11 and (68)Ga-BPAMD...
November 16, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27904874/imaging-of-accidental-contamination-by-fluorine-18-solution-a-quick-troubleshooting-procedure
#6
Kalevi Kairemo, Aki Kangasmäki
To the best of our knowledge, imaging of accidental exposure to radioactive fluorine-18 (F-18) due to liquid spill has not been described earlier in the scientific literature. The short half-life of F-18 (t½=110 min), current radiation safety requirements, and Good Manufacturing Practice (GMP) regulations on radiopharmaceuticals have restrained the occurrence of these incidents. The possibility of investigating this type of incidents by gamma and positron imaging is also quite limited. Additionally, a quick and precise analysis of radiochemical contamination is cumbersome and sometimes challenging if the spills of radioactive materials are low in activity...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904871/in-vivo-measurement-and-characterization-of-a-novel-formulation-of-177-lu-dota-octreotate
#7
Dale L Bailey, Thomas M Hennessy, Kathy P Willowson, E Courtney Henry, David Lh Chan, Alireza Aslani, Paul J Roach
OBJECTIVES: Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as "No Carrier Added" (NCA) (177)Lu. We have radiolabelled DOTA-conjugated peptide DOTA-(Tyr(3))-octreotate with NCA (177)Lu ("NCA-LuTATE") and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on our initial studies on aspects of the biodistribution and dosimetry of NCA-LuTATE from gamma camera 2D whole body (WB) and quantitative 3D SPECT (qSPECT) (177)Lu imaging...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27900521/-18-f-fluorodihydroxyphenylalanine-pet-ct-in-pheochromocytoma-and-paraganglioma-relation-to-genotype-and-amino-acid-transport-system-l
#8
Chloé C Feral, Floriane S Tissot, Lionel Tosello, Nicolas Fakhry, Fréderic Sebag, Karel Pacak, David Taïeb
PURPOSE: F-FDOPA is a highly sensitive and specific radiopharmaceutical for pheochromocytoma and paraganglioma (PPGL) imaging. However, (18)F-FDOPA might be falsely negative in these tumors, especially those related to mutations in succinate dehydrogenase genes (SDHx). The aim of the present study was to evaluate the relationship between expression of L-DOPA transporters and (18)F-FDOPA PET imaging results in PPGL. METHODS: From 2007 to 2015, 175 patients with non-metastatic PPGL were evaluated by (18)F-FDOPA PET/CT for initial diagnosis/staging and follow-up...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900520/nuclear-medicine-imaging-of-multiple-myeloma-particularly-in-the-relapsed-setting
#9
REVIEW
Esther G M de Waal, Andor W J M Glaudemans, Carolien P Schröder, Edo Vellenga, Riemer H J A Slart
Multiple myeloma (MM) is characterized by a monoclonal plasma cell population in the bone marrow. Lytic lesions occur in up to 90 % of patients. For many years, whole-body X-ray (WBX) was the method of choice for detecting skeleton abnormalities. However, the value of WBX in relapsing disease is limited because lesions persist post-treatment, which restricts the capacity to distinguish between old, inactive skeletal lesions and new, active ones. Therefore, alternative techniques are necessary to visualize disease activity...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900331/corrigendum-to-design-of-cgmp-production-of-18-f-and-68-ga-radiopharmaceuticals
#10
Yen-Ting Chi, Pei-Chun Chu, Hao-Yu Chao, Wei-Chen Shieh, Chuck C Chen
[This corrects the article DOI: 10.1155/2014/680195.].
2016: BioMed Research International
https://www.readbyqxmd.com/read/27897034/meditative-music-listening-to-reduce-state-anxiety-in-patients-during-the-uptake-phase-before-positron-emission-tomography-pet-scans
#11
Wen-Li Lee, Huei-Chuan Sung, Shu-Hsin Liu, Shu-Min Chang
OBJECTIVE: This study examines the effects of meditative music listening on state anxiety and heart rate variability (HRV) of patients during uptake phase before PET scans. METHODS: A two-group randomized experimental design was used. Eligible patients were randomly assigned to either experimental or control group. All patients received baseline assessments of state anxiety using Spielberger Trait Anxiety Inventory (STAI-S) and HRV before receiving an intravenous injection of radiopharmaceutical fludeoxyglucose in uptake room...
November 29, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27896673/the-clinical-safety-biodistribution-and-internal-radiation-dosimetry-of-18-f-ah113804-in-healthy-adult-volunteers
#12
E J Somer, R Owenius, A Wall, G Antoni, A Thibblin, J Sörensen
BACKGROUND: Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 ((18)F) Injection in six healthy volunteers (HVs), four males and two females, up to approximately 5 h post-injection. For each subject, key organs and tissues were delineated and analytical fits were made to the image data as functions of time to yield the normalised cumulated activities. These were input to an internal radiation dosimetry calculation based upon the Medical Internal Radiation Dose (MIRD) schema for the Cristy-Eckerman adult male or female phantom...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27896370/william-c-klingesmith-iii-the-mathematics-and-biology-of-the-biodistribution-of-radiopharmaceuticals-a-clinical-perspective-springer-international-publishing-switzerland-2016-isbn-978-3-319-26702-9
#13
Teresa Mannarino, Luigi Mansi
No abstract text is available yet for this article.
November 28, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27893426/sublethal-exposure-to-alpha-radiation-223ra-dichloride-enhances-various-carcinomas-sensitivity-to-lysis-by-antigen-specific-cytotoxic-t-lymphocytes-through-calreticulin-mediated-immunogenic-modulation
#14
Anthony S Malamas, Sofia R Gameiro, Karin M Knudson, James W Hodge
Radium-223 dichloride (Xofigo®; 223Ra) is an alpha-emitting radiopharmaceutical FDA-approved for the treatment of bone metastases in patients with advanced castration-resistant prostate cancer. It is also being examined clinically in patients with breast and lung carcinoma and patients with multiple myeloma. As with other forms of radiation, the aim of 223Ra is to reduce tumor burden by directly killing tumor cells. External beam (photon) and proton radiation have been shown to augment tumor sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes (CTLs)...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27885083/internal-dose-assessment-of-new-177lu-radiopharmaceuticals-and-its-role-in-radiation-protection-of-patients
#15
Nancy Puerta Yepes, Ana Rojo, Sebastián Gossio, José Luis Crudo
Since 2006, CNEA has been conducting studies on the production, labeling, quality control and NIH mice biodistribution of several radiopharmaceuticals based on (177)Lu locally produced. In order to contribute to ensuring the radiation protection of patients, the Internal Dosimetry Laboratory of the ARN has been complementing the preclinical study performing a dose assessment. This assessment included: the activity biodistribution analysis in NIH mice, the estimation of the absorbed dose, the extrapolation of the results to humans, the identification of healthy organs with high risk and the estimation of the maximum activity that can be administered to a patient without exceeding the threshold of radiotoxicity in healthy organs...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27862213/synthesis-and-preliminary-biological-evaluation-of-a-99m-tc-chlorambucil-derivative-as-a-potential-tumor-imaging-agent
#16
Jianguo Lin, Ling Qiu, Gaochao Lv, Ke Li, Wei Wang, Guiqing Liu, Xueyu Zhao, Shanshan Wang
Technetium-99 m-based radiopharmaceuticals have been used widely as diagnostic agents in the nuclear medicine. Chlorambucil (CLB) as one typical alkylating drug exhibits excellent inhibition effects against many human malignancies. In order to develop and explore a novel potential imaging agent for early diagnosis of tumors, tricarbonyl technetium-99 m and rhenium complexes based on the tridentate ligand dipicolylamine (DPA) bound to the chlorambucil pharmacophore were designed and synthesized: (99m) Tc-DPA-CLB (3) and Re-DPA-CLB (4)...
November 16, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27862203/production-quality-control-and-determination-of-human-absorbed-dose-of-no-carrier-added-177-lu-risedronate-for-bone-pain-palliation-therapy
#17
Nafise Salek, Mohsen Mehrabi, Simindokht Shirvani Arani, Ali Bahrami Samani, Mostafa Erfani, Sara Vosoghi, Mohammad Ghannadi Maragheh, Mojtaba Shamsaei
In this study, the radiocomplexation of risedronic acid, a potent bisphosphonate with a no carrier added (NCA) (177) Lu, was investigated and followed by quality control studies, biodistribution evaluation, and dosimetry study for human based on biodistribution data in Wistar rats. The moderate energy β(-) emitter, (177) Lu (T½  = 6.7 days, Eβmax  = 497 keV), has been considered as a potential agent for development of bone-seeking radiopharmaceuticals. Because the specific activity of the radiolabeled carrier molecules should be high, the NCA radionuclides have an effective role in nuclear medicine...
November 15, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27859483/a-report-of-the-automated-radiosynthesis-of-the-tau-pet-radiopharmaceutical-18-f-thk-5351
#18
Ramesh Neelamegam, Daniel L Yokell, Peter A Rice, Shozo Furumoto, Yukitsuka Kudo, Nobuyuki Okamura, Georges El Fakhri
The radiotracer, [(18) F]-THK-5351 is a highly selective and high binding affinity PET imaging agent for aggregates of hyper-phosphorylated tau protein. Our report is a simplified one-pot, two-step radiosynthesis of [(18) F]-THK-5351. This report is broadly applicable for routine clinical production and multi-center trials on account of favorable half-life of flourine-18 and the use of a commercially available radiosynthesis module, the GE TRACERlab™ FXFN . First, the O-THP protected tosyl precursor underwent nucleophilic fluorinating reaction with potassium cryptand fluoride ([(18) F] fluoride (K[(18) F]/K222 )) in DMSO at 110 °C for 10 min followed by O-THP removal by using diluted hydrochloric acid (HCl) at same temperature...
November 17, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27857516/sentinel-lymph-node-scintigraphy-in-cutaneous-melanoma-using-a-planar-calibration-phantom-filled-with-tc-99m-pertechnetate-solution-for-body-contouring
#19
Claudiu Peştean, Elena Bărbuş, Andra Piciu, Maria Iulia Larg, Alexandrina Sabo, Cristina Moisescu-Goia, Doina Piciu
BACKGROUND AND AIMS: Melanoma is a disease that has an increasing incidence worldwide. Sentinel lymph node scintigraphy is a diagnostic tool that offers important information regarding the localization of the sentinel lymph nodes offering important input data to establish a pertinent and personalized therapeutic strategy. The golden standard in body contouring for sentinel lymph node scintigraphy is to use a planar flood source of Cobalt-57 (Co-57) placed behind the patients, against the gamma camera...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27853680/radiolabeled-theranostics-magnetic-and-gold-nanoparticles
#20
REVIEW
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar, Yadollah Omidi
Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems...
2016: BioImpacts: BI
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