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https://www.readbyqxmd.com/read/29455647/-99m-tc-hynic-tricine-edda-frop-peptide-for-mcf-7-breast-tumor-targeting-and-imaging
#1
Sajjad Ahmadpour, Zohreh Noaparast, Seyed Mohammad Abedi, Seyed Jalal Hosseinimehr
BACKGROUND: Breast cancer is the most common malignancy among women in the world. Development of novel tumor-specific radiopharmaceuticals for early breast tumor diagnosis is highly desirable. In this study we developed99m Tc-HYNIC-(tricine/EDDA)-Lys-FROP peptide with the ability of specific binding to MCF-7 breast tumor. METHODS: The FROP-1 peptide was conjugated with the bifunctional chelator hydrazinonicotinamide (HYNIC) and labeled with99m Tc using tricine/EDDA co-ligand...
February 19, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29452623/currently-available-radiopharmaceuticals-for-imaging-infection-and-the-holy-grail
#2
REVIEW
Ebru Salmanoglu, Sung Kim, Mathew L Thakur
Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452617/imaging-of-spondylodiscitis
#3
REVIEW
Meera Raghavan, Elena Lazzeri, Christopher J Palestro
Spondylodiscitis is an infection of the vertebral body or disc and may also involve the epidural space, posterior elements, and paraspinal soft tissues. It is a cause of morbidity and mortality, and warrants early diagnosis and prompt treatment. Diagnosis can be difficult because of nonspecific signs and symptoms. Magnetic resonance imaging is sensitive and specific and is the imaging modality of choice for spondylodiscitis. Gadolinium contrast can show the extent of soft tissue and bone phlegmon and abscess...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29450723/molecular-imaging-and-theranostic-approaches-in-pheochromocytoma-and-paraganglioma
#4
REVIEW
David Taïeb, Karel Pacak
Pheochromocytomas and their extra-adrenal counterpart paragangliomas (PGLs; together called PPGLs), belong to the family of neural crest-derived tumors. Given the overexpression of a wide variety of specific targets in PPGLs, it seems that these tumors are optimally suited to be imaged by specific radiopharmaceuticals. Thus, theranostics approaches with somatostatin agonists and antagonists are rapidly evolving in the setting of these tumors and may be considered as the next step in the therapeutic arsenal of metastatic PPGLs...
February 15, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29448240/evaluation-of-production-cross-sections-for-186-re-theranostic-radionuclide-via-charged-particle-induced-reactions-on-tungsten
#5
Samer K I Ali, Mayeen Uddin Khandaker, H A Kassim
186 Re (T 1/2 = 89.24 h, [Formula: see text] 346.7 keV, [Formula: see text] ), an intense beta-emitter shows great potential to be used as an active material in therapeutic radiopharmaceuticals due to its suitable physico-chemical properties. 186 Re can be produced in several ways, however charged-particle induced reactions show to be promising towards no carrier added production. In this work, production cross-sections of 186 Re were evaluated following the light-charged particle induced reactions on tungsten...
January 31, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29447122/-18-f-fdg-production-procedures-as-a-source-of-eye-lens-exposure-to-radiation
#6
Małgorzata Wrzesień
Decreasing the individual dose limit of exposure to ionizing radiation to the eye lenses means verifying the need for routine monitoring of the eye lenses of workers exposed to ionizing radiation, including those employed in facilities producing radiopharmaceuticals based on short-lived isotopes. This work analyzes the exposure of the eye lenses of employees of centers that produce the isotopes for positron emission tomography, in particular fluorine-18. It takes into account the employment structure and work system of the discussed centers, including in terms of changing the dose limit of exposure to the eye lenses...
February 15, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29442346/modification-of-a-two-blood-sample-method-used-for-measurement-of-gfr-with-99mtc-dtpa
#7
Marian J Surma, Anna Płachcińska, Jacek Kuśmierek
BACKGROUND: Measurements of GFR may be performed with a slope/intercept method (S/I), using only two blood samples taken in strictly defined time points. The aim of the study was to modify this method in order to extend time intervals suitable for blood sampling. Modification was based on a variation of a Russel et al. model parameter, selection of time intervals suitable for blood sampling and assessment of uncertainty of calculated results. MATERIAL AND METHODS: Archived values of GFR measurements of 169 patients with different renal function, from 5...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29438008/pet-radiopharmaceuticals-what-s-new-what-s-reimbursed-and-what-s-next
#8
Bonnie N Clarke
The field of molecular imaging is undergoing a period of growth and expansion. Of the ten FDA-approved PET imaging agents, six have been approved since 2012. As we enter 2018, we await the approval of a targeted radionuclide therapy, 177 Lu-DOTATATE. The approval of agents such as 11 C-choline represented a paradigm shift in radiopharmaceutical drug development. This shift has illuminated a path to approval for similar agents and demonstrated the importance of molecular imaging in determining effective treatment strategies in serious diseases...
February 2, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29430110/vitamins-e-and-c-prevent-dna-double-strand-breaks-in-peripheral-lymphocytes-exposed-to-radiations-from-iodine-131
#9
Mehdi Safaei, Seyed Masoud Jafarpour, Mehran Mohseni, Morteza Salimian, Hossein Akbari, Fateme Karami, Akbar Aliasgharzadeh, Bagher Farhood
Purpose: Iodine-131 is used as a radiopharmaceutical to treat thyroid cancer. The current study aimed to evaluate the effects of vitamins E and C on the level of DNA double-strand breaks (DSBs) caused by Radioiodine-131 (I-131) in human lymphocytes. Materials and Methods: Whole blood samples from human volunteers were incubated with a certain concentration of vitamins. After 1-h incubation, the samples were incubated with 20 μCi I-131/2 mL (blood + NaCl) for 1 h...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29430106/radiation-dose-to-the-occupational-worker-during-the-synthesis-of-188re-labeled-radiopharmaceuticals-in-the-nuclear-medicine-department
#10
Parul Thakral, Jyotsna, Pankaj Tandon, Sugandha Dureja, Vineet Pant, Ishita Sen
Aim: The aim of this study is to estimate whole-body radiation dose to the radiopharmacist involved in labeling of three different 188Re-labeled compounds, namely, 188Re-Lipiodol, 188Re-tin colloid, and 188Re-hydroxyl-ethylidene-diphosphonate (HEDP) and to compare the occupational burden with the dose limits recommended by Atomic Energy Regulatory Board, India. Materials and Methods: The Department of Nuclear Medicine at Fortis Memorial Research Institute currently synthesizes three different Rhenium-188 labeled compounds, namely, 188Re-Lipiodol, 188Re-HEDP, and 188Re-tin colloid...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29419481/noninvasive-whole-body-imaging-of-phosphatidylethanolamine-as-a-cell-death-marker-using-99mtc-duramycin-during-tnf-induced-sirs
#11
Tinneke Delvaeye, Leonie Wyffels, Steven Deleye, Kelly Lemeire, Amanda Gonçalves, Elke Decrock, Steven Staelens, Luc Leybaert, Peter Vandenabeele, Dmitri Krysko
Systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. It is associated with the presence of pro- and anti-inflammatory cytokines in serum, including tumor necrosis factor (TNF). TNF has multiple effects and leads to cytokine production, leukocyte infiltration, blood pressure reduction and coagulation, thereby contributing to tissue damage and organ failure. A sterile mouse model of sepsis, TNF-induced SIRS, was used to visualize the temporal and spatial distribution of damage in susceptible tissues during SIRS...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29419478/18f-fludarabine-pet-for-lymphoma-imaging-first-in-man-study-in-dlbcl-and-cll-patients
#12
Sylvain Chantepie, Narinée Hovhannisyan, Stéphane Guillouet, Jean-Pierre Pelage, Méziane Ibazizene, Caroline Bodet-Milin, Thomas Carlier, Anne-Claire Gac, Emilie Réboursière, Jean-Pierre Vilque, Françoise Kraeber-Bodéré, Alain Manrique, Gandhi Damaj, Michel Leporrier, Louisa Barré
This is the first in-man clinical study of 18F-fludarabine which is a radiopharmaceutical for PET imaging in lymphoma where many issues remain controversial with the standard radiotracer 18F-FDG. Methods:18F-Fludarabine-PET(/CT) was performed in 10 patients: five with diffuse large B-cell lymphoma (DLBCL) and five with chronic lymphocytic leukemia (CLL). The biodistribution, and radiation dosimetry of 18F-fludarabine have also been evaluated. Six successive partial body PET scans were acquired for 250 min after intravenous 4 MBq/kg bolus of 18F-fludarabine...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29417412/radiopharmaceuticals-for-cardiac-imaging-current-status-and-future-trends
#13
EDITORIAL
Raymond Taillefer, Francois Harel
No abstract text is available yet for this article.
February 7, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29413839/monte-carlo-dose-distribution-calculation-at-nuclear-level-for-auger-emitting-radionuclide-energies
#14
S Di Maria, A Belchior, Y Romanets, A Paulo, P Vaz
The distribution of radiopharmaceuticals in tumor cells represents a fundamental aspect for a successful molecular targeted radiotherapy. It was largely demonstrated at microscopic level that only a fraction of cells in tumoral tissues incorporate the radiolabel. In addition, the distribution of the radionuclides at sub-cellular level, namely inside each nucleus, should also be investigated for accurate dosimetry estimation. The most used method to perform cellular dosimetry is the MIRD one, where S-values are able to estimate cellular absorbed doses for several electron energies, nucleus diameters, and considering homogeneous source distributions...
January 17, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29412489/preclinical-optimization-of-antibody-based-radiopharmaceuticals-for-cancer-imaging-and-radionuclide-therapy-model-vector-and-radionuclide-selection
#15
Lukas M Carter, Sophie Poty, Sai Kiran Sharma, Jason S Lewis
Intact antibodies and their truncated counterparts (e.g. Fab, scFv fragments) are generally exquisitely specific and selective vectors, enabling recognition of individual cancer-associated molecular phenotypes against a complex and dynamic biomolecular background. Complementary alignment of these advantages with unique properties of radionuclides is a defining paradigm in both radioimmunoimaging and radioimmunotherapy, which remain some of the most adept and promising tools for cancer diagnosis and treatment...
February 7, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29412229/influence-of-biomaterials-on-scintigraphic-diagnosis-of-periprosthetic-infections-ceftizoxime-99m-technetium-model
#16
Luiz Eduardo Moreira Teixeira, Bruno Jannotti Pádua, André Moreira Castilho, Ivana Duval de Araújo, Marco Antônio Percope de Andrade, Valbert Nascimento Cardoso, Simone Odília Diniz, Jefferson Soares Leal, Isabella Kuniko Takenaka
PURPOSE: To compare the influence of two metallic implants in the diagnosis of periprosthetic infection using 99m technetium-labeled ceftizoxime. METHODS: Twenty rats were randomly divided into four groups, which received sterile and contaminated titanium and stainless steel implants. After 3 weeks, scintilographic images were obtained using a gamma chamber. Radioactivity counts were obtained for the region of interest (ROI) on the operated and non-operated paws...
January 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29411226/from-carbon-11-labeled-amino-acids-to-peptides-in-positron-emission-tomography-the-synthesis-and-clinical-application
#17
REVIEW
Aleksandra Pekošak, Ulrike Filp, Alex J Poot, Albert D Windhorst
Radiolabeled amino acids, their derivatives and peptides have a broad scope of application and can be used as receptor ligands, as well as enzyme substrates for many different diseases as radiopharmaceutical tracers. Over the past few decades, the application of molecular imaging techniques such as positron emission tomography (PET) has gained considerable importance and significance in diagnosis in today's advanced health care. Next to that, the availability of cyclotrons and state-of-the-art radiochemistry facilities has progressed the production of imaging agents enabling the preparation of many versatile PET radiotracers...
February 6, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29400452/stable-and-inert-yttrium-iii-complexes-with-pyclen-based-ligands-bearing-pendant-picolinate-arms-toward-new-pharmaceuticals-for-%C3%AE-radiotherapy
#18
Mariane Le Fur, Maryline Beyler, Enikő Molnár, Olivier Fougère, David Esteban-Gómez, Gyula Tircsó, Carlos Platas-Iglesias, Nicolas Lepareur, Olivier Rousseaux, Raphaël Tripier
We report the synthesis of two azaligands based on the pyclen macrocyclic platform containing two picolinate and one acetate pendant arms. The two ligands differ in the relative positions of the pendant functions, which are arranged either in a symmetrical (L3) or nonsymmetrical (L4) fashion. The complexation properties of the ligands toward natY3+ and 90Y3+ were investigated to assess their potential as chelating units for radiopharmaceutical applications. The X-ray structures of the YL3 and YL4 complexes show nonadentate binding of the ligand to the metal ions...
February 5, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29398564/the-mindview-project-first-results
#19
José M Benlloch, Antonio J González, Roberto Pani, Enrico Preziosi, Carl Jackson, John Murphy, Julio Barberá, Carlos Correcher, Sebastian Aussenhofer, Daniel Gareis, Dimitris Visvikis, Julien Bert, Bengt Langstrom, Lars Farde, Miklos Toth, Jenny Haggkvist, Fabio V Caixeta, Klas Kullander, Ian Somlai-Schweiger, Markus Schwaiger
We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient...
February 1, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29396636/imaging-%C3%AE-v%C3%AE-3-integrin-expression-in-skeletal-metastases-with-99mtc-maraciclatide-single-photon-emission-computed-tomography-detection-and-therapy-response-assessment
#20
Gary J R Cook, Gurdip K Azad, Benjamin P Taylor, Eugene Lee, Matthew S Morrison, Simon Hughes, Stephen Morris, Sarah Rudman, Simon Chowdhury, Vicky Goh
PURPOSE: Osteoclast activity is an important factor in the pathogenesis of skeletal metastases and is a potential therapeutic target. This study aimed to determine if selective uptake of 99mTc-maraciclatide, a radiopharmaceutical targeting αvβ3 integrin, occurs in prostate cancer (PCa) bone metastases and to observe the changes following systemic therapy. METHODS: The study group comprised 17 men with bone-predominant metastatic PCa who underwent whole-body planar and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging with 99mTc-maraciclatide before (n = 17) and 12 weeks after (n = 11) starting treatment with abiraterone...
February 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
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