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https://www.readbyqxmd.com/read/28334240/the-use-of-rbans-among-inpatient-forensic-monolingual-spanish-speakers
#1
Cynthia Aguilar, Kenny A Karyadi, Dominique I Kinney, Stephen R Nitch
Objective: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been shown to be an effective screener for detecting neurocognitive impairments in English speaking forensic psychiatric inpatients, but no studies have examined whether the RBANS would have the same utility among monolingual Spanish speaking inpatients. This study sought to examine RBANS performance, as well as risk factors (i.e., educational, neurological, and medical) influencing RBANS performance, in that particular population...
February 18, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28292442/eto2-glis2-hijacks-transcriptional-complexes-to-drive-cellular-identity-and-self-renewal-in-pediatric-acute-megakaryoblastic-leukemia
#2
Cécile Thirant, Cathy Ignacimouttou, Cécile K Lopez, M'Boyba Diop, Lou Le Mouël, Clarisse Thiollier, Aurélie Siret, Phillipe Dessen, Zakia Aid, Julie Rivière, Philippe Rameau, Céline Lefebvre, Mehdi Khaled, Guy Leverger, Paola Ballerini, Arnaud Petit, Hana Raslova, Catherine L Carmichael, Benjamin T Kile, Eric Soler, John D Crispino, Christian Wichmann, Françoise Pflumio, Jürg Schwaller, William Vainchenker, Camille Lobry, Nathalie Droin, Olivier A Bernard, Sébastien Malinge, Thomas Mercher
Chimeric transcription factors are a hallmark of human leukemia, but the molecular mechanisms by which they block differentiation and promote aberrant self-renewal remain unclear. Here, we demonstrate that the ETO2-GLIS2 fusion oncoprotein, which is found in aggressive acute megakaryoblastic leukemia, confers megakaryocytic identity via the GLIS2 moiety while both ETO2 and GLIS2 domains are required to drive increased self-renewal properties. ETO2-GLIS2 directly binds DNA to control transcription of associated genes by upregulation of expression and interaction with the ETS-related ERG protein at enhancer elements...
March 13, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28276597/an-international-perspective-on-feigned-mental-disabilities-conceptual-issues-and-continuing-controversies
#3
Thomas Merten, Richard Rogers
In forensic contexts, an increased prevalence of feigned symptom presentations should be expected, although it will probably vary by the context and specific forensic issue. Forensic experts should examine this possibility proactively while maintaining a balanced perspective that actively considers clinical data for both feigning and genuine responding. Psychological measures and standardized methods developed for feigning and other response styles can facilitate these often complex determinations. The current article provides an international perspective on the issue of feigned mental disabilities...
March 9, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/28252976/trial-1-versus-trial-2-of-the-test-of-memory-malingering-evaluating-accuracy-without-a-gold-standard
#4
Douglas Mossman, Dustin B Wygant, Roger O Gervais, Kathleen J Hart
This study examines the accuracy of the Test of Memory Malingering (TOMM), a frequently administered measure for evaluating effort during neurocognitive testing. In the last few years, several authors have suggested that the initial recognition trial of the TOMM (Trial 1) might be a more useful index for detecting feigned or exaggerated impairment than Trial 2, which is the source for inference recommended by the original instruction manual (Tombaugh, 1996). We used latent class modeling (LCM) implemented in a Bayesian framework to evaluate archival Trial 1 and Trial 2 data collected from 1,198 adults who had undergone outpatient forensic evaluations...
March 2, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28250565/multimodal-hallucinations-in-schizophrenia-and-its-management
#5
Vijaya Kumar, Virupakshappa Bagewadi, Dayanand Sagar, Shivarama Varambally
A cluster of symptoms including hallucinations characterizes schizophrenia. Hallucinations that occur in more than one modality simultaneously and emanate from a single source are called multimodal hallucinations (MMHs). The occurrence of simultaneous hallucinations as the major manifestations of a psychiatric disorder often was dismissed as factitious disorder or malingering. Conversely, MMHs have been reported in severe mental disorders including schizophrenia. Here, we report MMH in two patients of treatment-resistant schizophrenia and its successful management with clozapine...
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28169427/financial-incentive-does-not-affect-p300-in-response-to-certain-episodic-and-semantic-probe-stimuli-in-the-complex-trial-protocol-ctp-version-of-the-concealed-information-test-cit-in-detection-of-malingering
#6
J Peter Rosenfeld, Elena Labkovsky, Elena Davydova, Anne Ward, Lauren Rosenfeld
Previous research indicated that the skin conductance response of the autonomic nervous system in the Concealed Information Test (CIT) is typically increased in subjects who are financially and otherwise incentivized to defeat the CIT (the paradoxical "motivational impairment" effect). This is not the case for RT-based CITs, nor P300 tests based on the three-stimulus protocol for detection of cognitive malingering (although these are not the same as CITs). The present report is the first attempt to study the effect of financial motivation on the P300-based Complex Trial Protocol using both episodic and semantic memory probe and irrelevant stimuli...
February 7, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28156190/the-visual-association-test-extended-a-cross-sectional-study-of-the-performance-validity-measures
#7
Sascha R A Meyer, Jos F M de Jonghe, Ben Schmand, Rudolf W H M Ponds
OBJECTIVE: Given the hazards of knowledge about performance validity tests (PVTs) being proliferated among the general public, there is a continuous need to develop new PVTs. The purpose of these studies was to validate the newly developed Visual Association Test-Extended (VAT-E). METHOD: The VAT-E consists of 24 pairs of line drawings; it is partly based on Green's Word Memory Test (WMT) paradigm. In study 1, we compared VAT-E total scores of healthy controls (n = 226), patients with mild cognitive impairment (MCI) (n = 76), patients with Alzheimer's disease (AD) (n = 26), and persons instructed to feign memory deficit (n = 29)...
February 3, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28080105/cross-cultural-feigning-assessment-a-systematic-review-of-feigning-instruments-used-with-linguistically-ethnically-and-culturally-diverse-samples
#8
Alicia Nijdam-Jones, Barry Rosenfeld
The cross-cultural validity of feigning instruments and cut-scores is a critical concern for forensic mental health clinicians. This systematic review evaluated feigning classification accuracy and effect sizes across instruments and languages by summarizing 45 published peer-reviewed articles and unpublished doctoral dissertations conducted in Europe, Asia, and North America using linguistically, ethnically, and culturally diverse samples. The most common psychiatric symptom measures used with linguistically, ethnically, and culturally diverse samples included the Structured Inventory of Malingered Symptomatology, the Miller Forensic Assessment of Symptoms Test, and the Minnesota Multiphasic Personality Inventory (MMPI)...
January 12, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28078779/association-between-zika-virus-and-foetopathy-a-prospective-cohort-study-in-french-guiana-preliminary-report
#9
Léo Pomar, Gustavo Malinger, Guillaume Benoist, Gabriel Carles, Yves Ville, Dominique Rousset, Najeh Hcini, Céline Pomar, Anne Jolivet, Véronique Lambert
OBJECTIVES: The main objectives of the present study were to establish the existence of significant differences in the incidence of central nervous system (CNS) anomalies (including microcephaly), signs of congenital infection, or foetal loss between Zika virus (ZIKV)-infected and non-infected pregnant women in western French Guiana. METHODS: This prospective cohort study was conducted between January 1(st) and July 15(th) 2016. We evaluated the clinical and foetal ultrasound (US) examinations of 301 pregnant women with biological confirmation of ZIKV infection and 399 pregnant women who were negative for ZIKV infection...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28077000/specificity-rates-for-non-clinical-bilingual-mexican-americans-on-three-popular-performance-validity-measures
#10
Philip G Gasquoine, Amy A Weimer, Arnoldo Amador
OBJECTIVE: To measure specificity as failure rates for non-clinical, bilingual, Mexican Americans on three popular performance validity measures: (a) the language format Reliable Digit Span; (b) visual-perceptual format Test of Memory Malingering; and (c) visual-perceptual format Dot Counting, using optimal/suboptimal effort cut scores developed for monolingual, English-speakers. METHODS: Participants were 61 consecutive referrals, aged between 18 and 65 years, with <16 years of education who were subjectively bilingual (confirmed via formal assessment) and chose the language of assessment, Spanish or English, for the performance validity tests...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28053132/varieties-of-voice-hearing-psychics-and-the-psychosis-continuum
#11
Albert R Powers, Megan S Kelley, Philip R Corlett
Hearing voices that are not present is a prominent symptom of serious mental illness. However, these experiences may be common in the non-help-seeking population, leading some to propose the existence of a continuum of psychosis from health to disease. Thus far, research on this continuum has focused on what is impaired in help-seeking groups. Here we focus on protective factors in non-help-seeking voice-hearers. We introduce a new study population: clairaudient psychics who receive daily auditory messages...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28050112/progressive-severe-bilateral-loss-of-vision-in-a-relatively-young-patient-think-beyond-malingering
#12
Avinash Mishra, Sandeep Shankar, T S Ahluwalia, Raghudev Bhattacharjee
No abstract text is available yet for this article.
December 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28032009/assessment-of-feigned-cognitive-impairment-in-severe-traumatic-brain-injury-patients-with-the-forced-choice-graphics-memory-test
#13
Zilong Liu, Juan Dong, Xiaohong Zhao, Xiaorui Chen, Sara M Lippa, Jerome S Caroselli, Xiang Fang
INTRODUCTION: The Forced-choice Graphics Memory Test (FGMT) is a newly developed measure to assess feigned cognitive impairment. This study investigated the ability and reliability of FGMT for identification of malingering in patients with traumatic brain injury (TBI). METHODS: The FGMT was administered to 40 healthy volunteers instructed to respond validly (Healthy Control, H-C), 40 healthy volunteers instructed to feign cognitive impairment (Healthy Malingering, H-M), 40 severe TBI patients who responded validly (TBI control, TBI-C), and 30 severe TBI patients who evidenced invalid performance (TBI malingering, TBI-M)...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28029435/assessment-of-complex-dissociative-disorder-patients-and-simulated-dissociation-in-forensic-contexts
#14
Bethany L Brand, Aliya R Webermann, A Steven Frankel
Few assessors receive training in assessing dissociation and complex dissociative disorders (DDs). Potential differential diagnoses include anxiety, mood, psychotic, substance use, and personality disorders, as well as exaggeration and malingering. Individuals with DDs typically elevate on many clinical and validity scales on psychological tests, yet research indicates that they can be distinguished from DD simulators. Becoming informed about the testing profiles of DD individuals and DD simulators can improve the accuracy of differential diagnoses in forensic settings...
October 29, 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28029258/liposomes-for-pet-and-mr-imaging-and-for-dual-targeting-magnetic-field-glucose-moiety-synthesis-properties-and-in-vivo-studies
#15
Jérémy Malinge, Bastien Géraudie, Paul Savel, Valérie Nataf, Aurélie Prignon, Claire Provost, Yongmin Zhang, Phalla Ou, Khaldoun Kerrou, Jean-Noël Talbot, Jean-Michel Siaugue, Matthieu Sollogoub, Christine Ménager
We describe the potentiality of a new liposomal formulation enabling positron emission tomography (PET) and magnetic resonance MR() imaging. The bimodality is achieved by coupling a (68)Ga-based radiotracer on the bilayer of magnetic liposomes. In order to enhance the targeting properties obtained under a permanent magnetic field, a sugar moiety was added in the lipid formulation. Two new phospholipids were synthesized, one with a specific chelator of (68)Ga (DSPE-PEG-NODAGA) and one with a glucose moiety (DSPE-PEG-glucose)...
January 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28004196/a-method-for-identifying-color-vision-deficiency-malingering
#16
Andrew Pouw, Rustum Karanjia, Alfredo Sadun
PURPOSE: To propose a new test to identify color vision deficiency malingering. METHODS: An online survey was distributed to 130 truly color vision deficient participants and 160 participants willing to simulate color vision deficiency. The survey contained three sets of six color-adjusted versions of the standard Ishihara color plates each, as well as one set of six control plates. The plates that best discriminated both participant groups were selected for a "balanced" test emphasizing both sensitivity and specificity...
March 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28001485/optimizing-assembly-and-production-of-native-bispecific-antibodies-by-codon-de-optimization
#17
Giovanni Magistrelli, Yves Poitevin, Florence Schlosser, Guillemette Pontini, Pauline Malinge, Soheila Josserand, Marie Corbier, Nicolas Fischer
When production of bispecific antibodies requires the co-expression and assembly of three or four polypeptide chains, low expression of one chain can significantly limit assembly and yield. κλ bodies, fully human bispecific antibodies with native IgG structure, are composed of a common heavy chain and two different light chains, one kappa and one lambda. No engineering is applied to force pairing of the chains, thus both monospecific and bispecific antibodies are secreted in the supernatant. In this context, stoichiometric expression of the two light chains allows for maximal assembly of the bispecific antibody...
February 2017: MAbs
https://www.readbyqxmd.com/read/27982208/pattern-reversal-visual-evoked-potentials-as-a-diagnostic-tool-for-ocular-malingering
#18
Tarciana de Souza Soares, Paula Yuri Sacai, Adriana Berezovsky, Daniel Martins Rocha, Sung Eun Song Watanabe, Solange Rios Salomão
Purpose: To investigate the contributions of transient pattern-reversal visual evoked potentials in the diagnosis of ocular malingering at a Brazilian university hospital. Methods: Adult patients with suspected malingering in one or both eyes were referred for visual evoked potential testing. Data from patients' medical records were reviewed and analyzed retrospectively. Data analysis included the distance optotype visual acuity based on a ETDRS retro-illuminated chart and the transient pattern-reversal visual evoked potential parameters of latency (milliseconds) and amplitude (microvolts) for the P100 component, using checkerboards with visual subtenses of 15' and 60'...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27936001/computerized-analysis-of-verbal-fluency-normative-data-and-the-effects-of-repeated-testing-simulated-malingering-and-traumatic-brain-injury
#19
David L Woods, John M Wyma, Timothy J Herron, E William Yund
In verbal fluency (VF) tests, subjects articulate words in a specified category during a short test period (typically 60 s). Verbal fluency tests are widely used to study language development and to evaluate memory retrieval in neuropsychiatric disorders. Performance is usually measured as the total number of correct words retrieved. Here, we describe the properties of a computerized VF (C-VF) test that tallies correct words and repetitions while providing additional lexical measures of word frequency, syllable count, and typicality...
2016: PloS One
https://www.readbyqxmd.com/read/27930512/religious-stigmata-as-malingering-artifact-report-of-a-case-and-review-of-the-literature
#20
REVIEW
Domenico Bonamonte, Michelangelo Vestita, Angela Filoni, Giuseppe Giudice, Gianni Angelini
RATIONALE: Artifacts or simulated diseases are self-inflicted conditions caused by various means and for different purposes. Disease simulation can be motivated, among other things, by illegal purposes, to escape from civil duties or prison sentences, for example, or to exploit specific situations in order to receive a range of benefits. In such cases, the simulator is fully aware of his or her actions and intentions. DIAGNOSES, INTERVENTIONS AND OUTCOMES: We report the case of a 42-year-old woman who, for 3 consecutive years, showed religious stigmata on the forehead and on the dorsal surface of hands and feet immediately before Easter...
December 2016: Medicine (Baltimore)
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